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Imagerie cérébrale multimodale pour l'étude des aphasies primaires progressives

Abstract : Progressive primary aphasia (APP) is a group of neurodegenerative diseases affecting language abilities and presenting clinical, anatomical and biological/genetic heterogeneity. We first used anatomical MRI, diffusion MRI and FDG-PET imaging to provide a complete characterization of the different forms of PPA in a large cohort of patients at early stage of the disease. This study allowed to characterize the structural, microstructural and metabolic alteration patterns in each variant of PPA and to compare these alterations between the different imaging modalities. In the second part, we used the lesional model of PPA to study the networks of semantic processes. The use of tractography and the analysis of correlations between semantic deficits and white matter integrity in diffusion MRI allowed the identification of connections involved in verbal and non-verbal processes. These studies required the development of specific image analysis tools. In particular, the development of tools for the analysis of anatomical and diffusion MRI have been integrated into the Clinica software platform to make these tools easily usable by other researchers or clinicians.
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Alexandre Routier. Imagerie cérébrale multimodale pour l'étude des aphasies primaires progressives. Neurosciences [q-bio.NC]. Sorbonne Université, 2018. Français. ⟨NNT : 2018SORUS537⟩. ⟨tel-01992799v2⟩

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