Semantic modeling of an histopathology image exploration and analysis tool

Abstract : Semantic modelling of a histopathology image exploration and analysis tool. Recently, anatomic pathology (AP) has seen the introduction of several tools such as high-resolution histopathological slide scanners, efficient software viewers for large-scale histopathological images and virtual slide technologies. These initiatives created the conditions for a broader adoption of computer-aided diagnosis based on whole slide images (WSI) with the hope of a possible contribution to decreasing inter-observer variability. Beside this, automatic image analysis algorithms represent a very promising solution to support pathologist’s laborious tasks during the diagnosis process. Similarly, in order to reduce inter-observer variability between AP reports of malignant tumours, the College of American Pathologists edited 67 organ-specific Cancer Checklists and associated Protocols (CAP-CC&P). Each checklist includes a set of AP observations that are relevant in the context of a given organ-specific cancer and have to be reported by the pathologist. The associated protocol includes interpretation guidelines for most of the required observations. All these changes and initiatives bring up a number of scientific challenges such as the sustainable management of the available semantic resources associated to the diagnostic interpretation of AP images by both humans and computers. In this context, reference vocabularies and formalization of the associated knowledge are especially needed to annotate histopathology images with labels complying with semantic standards. In this research work, we present our contribution in this direction. We propose a sustainable way to bridge the content, features, performance and usability gaps between histopathology and WSI analysis.
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Lamine Traore. Semantic modeling of an histopathology image exploration and analysis tool. Bioengineering. Université Pierre et Marie Curie - Paris VI, 2017. English. ⟨NNT : 2017PA066621⟩. ⟨tel-01989420v2⟩

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