Skip to Main content Skip to Navigation
Theses

Structural analysis and investigation of the Staphylococcus aureus ribosome and potential anticancer drugs

Abstract : Ribosomes are ribo-nucleoprotein complexes that read mRNA to synthesize proteins. This is important to consider in the case of cancer cells, which show a global increase in protein synthesis to support their hyper-proliferative behaviour. Inhibitors of eukaryotic protein synthesis have been shown to have significant therapeutic potential to treat a wide range of human cancers. Recently we published a multidisciplinary study in which we unravel the mechanism of action of chlorolissoclimide (CL), a compound sharing chemical similarity to cycloheximide (CHX), but showing promising lower cytotoxicity. We were interested in the new types of interaction of CL with the ribosome and therefore we solved a new crystal structure of the S.cerevisiae 80S in complex with another lissoclimide compound at 3.1 Å resolution. The coupling of high-resolution structures with computationally-driven drug design and FRET analysis will further guide the design of more selective and less cytotoxic inhibitors.
Complete list of metadatas

Cited literature [396 references]  Display  Hide  Download

https://tel.archives-ouvertes.fr/tel-01987004
Contributor : Abes Star :  Contact
Submitted on : Sunday, January 20, 2019 - 1:01:53 AM
Last modification on : Friday, October 23, 2020 - 5:03:47 PM

File

KASHINSKAYA_Daniya_2017_ED414....
Version validated by the jury (STAR)

Identifiers

  • HAL Id : tel-01987004, version 1

Collections

Citation

Daniya Kashinskaya. Structural analysis and investigation of the Staphylococcus aureus ribosome and potential anticancer drugs. Biomolecules [q-bio.BM]. Université de Strasbourg, 2017. English. ⟨NNT : 2017STRAJ110⟩. ⟨tel-01987004⟩

Share

Metrics

Record views

237

Files downloads

735