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Effets d'une exposition chronique à la musique sur le vieillissement chez le rat Wistar

Abstract : Cognitive decline associated to aging impacts daily life of elderly. While the music practice appears as promising leisure activity to prevent cognitive decline in elder, little is known about the neurobiological mechanisms involved. The aim of this work was to study the effects of music exposure on behavioral performances and some neurobiological processes across aging in rats. Indeed, improved behavioral performances together with an increased hippocampal neurogenesis and a higher BDNF expression were reported after music exposure in both young and adult animals. Yet, no study has so far investigated these effects in aged rats. After a fine appraisal of the cognitive state in middle-aged Wistar rats (15 months), they were divided in two groups, exposed either to classic music or to white noise. Thereafter, a longitudinal follow up of 9 months was performed. We observed for the first time that chronic music exposure alleviated age-related cognitive decline. However, contrary to what was observed in adult animals, we did not reported any differences in age-related changes of hippocampal neurogenesis and BDNF expression. These promising results of a beneficial effect of music exposure in the field of aging still lay open the question about the underlying mechanisms in the context of aging of the beneficial effect of music exposure.
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Lou Rizzolo. Effets d'une exposition chronique à la musique sur le vieillissement chez le rat Wistar. Médecine humaine et pathologie. Normandie Université, 2018. Français. ⟨NNT : 2018NORMC420⟩. ⟨tel-01981821⟩

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