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Etude physico-chimique et valorisation de composés bioactifs de Parinari macrophylla Sabine (Chrysobalanaceae)

Abstract : Type 2 diabetes is often associated with oxidative stress that can lead to several metabolic complications. In Senegal, in addition to drug treatment, medicinal plants are still widely used in the treatment of this pathology. The aim of this work was to contribute to the enhancement of Senegalese biodiversity and more particularly to improve the phytochemical properties of Parinari macrophylla Sabine, traditionally used for the treatment of diabetes. For this, the total antiradical activity and at the molecular level of leaves and bark has been determined by the TEAC, ORAC and HPLC - ABTS-+ online methods. In addition, a phytochemical screening (precipitation reactions, CCM) was carried out and revealed several chemical groups of compounds such as flavonoids, tannins, terpenes, anthracenes, saponosides, cardiotonic heterosides and alkaloids. For the identification of active compounds, NMR and the molecular network approach (UHPLC-MS), identified chlorogenic acid, hyperoside, procyanidin B2 and other procyanidins. The in vitro study carried out on a RINm5F cellular model showed a low anti-radical activity of plant extracts against HX-XO-induced stress. However, the compounds identified in this study are known for their antioxidant and inhibitory effects on digestive enzymes responsible for glucose metabolism. This could justify the use of this plant in the treatment of type 2 diabetes by Senegalese traditional therapists.
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Mamadou Balde. Etude physico-chimique et valorisation de composés bioactifs de Parinari macrophylla Sabine (Chrysobalanaceae). Chimie théorique et/ou physique. Université de Strasbourg, 2018. Français. ⟨NNT : 2018STRAF013⟩. ⟨tel-01980092⟩

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