Impact de l'invalidation du gène codant pour l'indoleamine 2,3-dioxygénase dans la physiologie de l'épididyme chez les mammifères

Abstract : In mammals, IDO1 is induced in inflammatory situations and plays multiple and complicated roles in the modulation of both innate and adaptative immune responses. Interestingly, IDO1 is constitutively expressed by the epididymal epithelium where it is envisaged that it participates in the set up of an immunotolerant environment in order to down-regulate auto immune-responses against spermatozoa. To decipher the roles played by IDO1 in the physiology of the epididymis and consequently in the male reproductive function, we show in this thesis report data obtained on the IDO1 knock-out mouse model. Data collected suggest that indeed IDO1 is an immunomodulatory player in the epididymis epithelium where it contributes to the immunotolerogenic context towards spermatozoa. When absent (ie. in the Ido1-/- genetic background) it specifically increases epididymal inflammation and triggers various tissue responses that aim at restoring the immune equlibrium. In addition, the work presented here shows that some kynurenines are particularly well represented in the epididymal epithelium as well as on spermatozoa where they could play important roles.
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Aïcha Jrad Lamine. Impact de l'invalidation du gène codant pour l'indoleamine 2,3-dioxygénase dans la physiologie de l'épididyme chez les mammifères. Génétique. Université Blaise Pascal - Clermont-Ferrand II, 2012. Français. ⟨NNT : 2012CLF22263⟩. ⟨tel-01980043⟩

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