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, Claire Bardet 1. , Mayssam Khaddam 1 , Jiar Naji 1 , Benjamin R. Coyac 1,2,10 , Brigitte Baroukh 1 , Franck Letourneur 4 , Julie Lesieur 1 , Franck Decup 1,6 , Dominique Le Denmat 1, MEPE-Derived ASARM Peptide Inhibits Odontogenic Differentiation of Dental Pulp Stem Cells and Impairs Mineralization in Tooth Models of X-Linked Hypophosphatemia Benjamin Salmon 1, vol.2

. Métabolisme-du-phosphore, A. Du-calcium, and K. Bicêtre,

, APHP Endocrinology and Diabetology for Children

, At 7, 14 and 21 days, the collagen matrices seeded with SHEDs were gently removed from the tooth slices and processed for total protein extraction using ice-cold extraction buffer (each collagen scaffold was placed in 100 ml buffer: 50 mM Tris-HCl, pH 7.5, containing 5 mM EDTA, 150 mM NaCl and 0.2% Triton X100), supplemented with 1/100 Protease Inhibitor Cocktail Set V EDTA free (Calbiochem, Membranes were incubated overnight at 4uC with monoclonal antiDSP, vol.12, 2000.

, The rats were sacrificed after one month and X-ray microcomputed tomography (micro-CT) analysis was performed on the treated molars (Skyscan Model 1172, Kontich, Belgium).-ASARM) ASARM peptide for 21 days were visualized by light microscopy and by scanning (SEM) and transmission (TEM) electron microscopy. A,B: SEM reveals SHEDs (arrows) well integrated into the collagen scaffold. Mineralization of the cultures appears as nodules within the collagen scaffold (arrowheads) only in the M and the M+np-ASARM conditions. Energy-dispersive X-ray spectroscopy (EDX) for compositional microanalysis of the nodules (performed at the white square) shows major spectral peaks for calcium (Ca) and phosphorus (P) with an acquired Ca/P ratio of 1, Membranes were incubated with a peroxidase-linked swine antirabbit secondary antibody (1/10,000) for 2 hrs at room temperature, then rinsed and followed by enhanced chemiluminescence detection of bound primary antibodies (Roche Diagnostics

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