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Etude des relations os/muscle et projet de courbes de référence de la densité minérale osseuse et de la composition corporelle chez l’homme jeune : étude multicentrique française

Abstract : Our short-term goal is to establish French reference curves of bone mineral density (BMD) and body composition once we have data from all centers. We have therefore carried out two preliminary studies for this project whose objectives are as follows: A) To study the determinants of whole body BMD but also bone site specific in relation to measurements of body composition, muscle strength and physical activity in young men B) Cross-calibration in vitro of bone mineral density and body composition parameters measured by dual energy X-ray absorptiometry (DXA) in order to establish in vivo the correction factors to be used in our baseline project in young men. Using DXA, our study confirmed that lean mass was the most important factor associated with BMD parameters at all bone sites and fat mass had a negative impact on BMD. Grip strength was significantly but moderately correlated with BMD at all sites. No association was found between physical activity and BMD. Regarding cross-calibration, the results showed that the oscillation of the results between the different DXA centers is a problem for multicenter studies and in particular for the evaluation of body composition. Cross-calibration allowed us to calculate the corrective factors to be applied to the data from the centers involved. In order to limit these variations, it would be desirable to develop a standard whole-body phantom that would be used for multicentre studies.
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Submitted on : Wednesday, January 9, 2019 - 3:06:06 PM
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Thibault Sutter. Etude des relations os/muscle et projet de courbes de référence de la densité minérale osseuse et de la composition corporelle chez l’homme jeune : étude multicentrique française. Physiologie [q-bio.TO]. Université d'Orléans, 2018. Français. ⟨NNT : 2018ORLE2006⟩. ⟨tel-01975719⟩

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