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. Alberts, 12 3 The force-relationship between adhesion, contraction and polymer network expansion determines the 'amoeboid' phenotype [ Lämmermann and Sixt, 2009.

I. Mcgregor, Internal organization of the nucleus and its connection to the cytoskeleton. Modified from, p.20, 2016.

. , Experimental compression and perfusion setups to be reproduced by simulation

. .. , 25 I.6 Simulation of compression and release of the nucleus

. , Parametric study on E nucl eopl asm,0

, Deviatoric strain for various values of plasticity threshold and ? nucl eopl asm 30

I. , Cell and micro-channel geometry

. , Profile of the fluid velocity inside the device

A. , 33 I.13 Simulation results of the perfusion test in the 5 µm-wide micro-channel for a wild-type cell, 2014.

. , Comparison of the perfusion test results in the 5 µm-wide micro-channel for the wild-type and the lamin-deficient model

I. , Simulation results of the perfusion test in the 1 µm-wide micro-channel for a wild-type cell

. , Comparison of the perfusion test results in the 1 µm-wide micro-channel for wild type and lamin deficient cells

I. C. , 1 Displacement of the mobile upper plate

I. E. , Parametric study on E cl

I. E. ,

I. E. , Parametric study on ? cl

I. E. , Parametric study on E cl

I. E. , Parametric study on E l

I. E. , Parametric study on ? cl

. , Illustration of the chimneying mechanism as a rock climbing method and as a bleb-based migration mode, p.61

L. Of-figures,

. , Illustration of the basic structure of a contractile fiber and myosin's powerstroke

]. .. , 64 II.4 Colorized Scanning Electron Microscope image a neuron, p.65, 2008.

. .. , 72 II.7 Graphical representation of the regularized active strain during four cycles of 30 s each

, Results of the poroelastic migration simulation in the absence of friction, p.76

. .. , 77 II.10 Graphical representation of the total force applied to the cell, p.78

. Ii, 11 Friction force along the cell profile at various time points, p.79

I. .. , Cell front displacement-Parametric study on a) µ f b) E cel l c) c p, f, p.81

. Badique, Example of micro-fabricated PDMS micro-pillars array, 2013.

]. .. , 93 III.3 Illustration of the engagement of the "molecular clutch" when actin filaments connect to integrins to build focal adhesions, p.95, 2007.

. , Push or pull" hypotheses: the cell nucleus is either pushed through the contraction of the perinuclear actin cap or pulled by contractile fibers (in green) towards the pillars

. , Experimental process to test the influence of gravity on nuclear deformation during cell spreading. Modified from, p.99, 2012.

. , III.7 Illustration of the material model and relationship between the configurations

. .. , 111 III.10 Interpenetration depth of the contact between the cell and the pillars during the simulation

. , 11 Illustration of the adhesive layer over the substrate in the case of the micro-pillared substrate

. , 12 Illustration of the spreading force f spr ead , directed radially, thus effectively spreading the cell over the substrate and creating an adhesion, p.114

. , 13 Illustration of the active zones in the cell with the PAC in blue and the bottom zone checkered in green

. , 14 Geometry of the cell in the initial condition of the system, p.117

. .. Overlayer and . Cuvelier, 118 III.16 Contact radius of the cell spreading over a flat substrate as function of time, as defined in, III.15 Cell spreading on a flat substrate with its, 2007.

. , 17 Geometry of the cell and the micro-pillared substrate in the initial configuration of the system

. .. , 18 Displacement d n of the bottom point of the nucleus for different configuration: Push & Pull (blue), Push (green) and Pull (orange), p.120

. .. , Simulation results for Push, Pull and Push & Pull simulation, p.121

. , Displacement of the top point of the cell for different configuration: Upside down (blue) and Control (orange)

. , III.C.1Geometry of the active domains in the cell and definition of ? P AC and ? bot t om

. , Numerical simulation of a self-synchronized pseudo-confined cell migration model