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Inclusion body myopathyassociated mutations in p97/VCP impair endoplasmic reticulum-associated degradation, Hum. Mol. Genet, vol.15, pp.189-199, 2006. ,
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VCP is essential for mitochondrial quality control by PINK1/Parkin and this function is impaired by VCP mutations, Neuron, vol.78, pp.65-80, 2013. ,
TDP-43 mediates degeneration in a novel Drosophila model of disease caused by mutations in VCP/p97, J Neurosci, vol.30, issue.22, pp.7729-7768, 2010. ,
P97/CDC-48: Proteostasis control in tumor cell biology, Cancer Lett, vol.337, issue.1, pp.26-34, 2013. ,
VCP/p97, down-regulated by microRNA129-5p, could regulate the progression of hepatocellular carcinoma, PLoS One, vol.7, issue.4, p.35800, 2012. ,
Increased expression of valosin-containing protein (p97) is correlated with disease recurrence in follicular thyroid cancer, Ann.Surg. Oncol, vol.12, pp.925-934, 2005. ,
Elevated expression of valosin-containing protein (p97) is associated with poor prognosis of prostate cancer, Clin. Cancer Res, vol.10, pp.3007-3012, 2004. ,
Ubiquitin-associated domaincontaining ubiquitin regulatory X (UBX) protein UBXN1 is a negative regulator of nuclear factor kappaB (NF-kappaB) signaling, J Biol Chem, vol.290, issue.16, pp.10395-405, 2015. ,
Sorafenib-mediated targeting of the AAA(+) ATPase p97/VCP leads to disruption of the secretory pathway, endoplasmic reticulum stress, and hepatocellular cancer cell death, Mol Cancer Ther, vol.11, issue.12, pp.2610-2630, 2012. ,
Covalent and allosteric inhibitors of the ATPase VCP/p97 induce cancer cell death, Nat Chem Biol, vol.9, issue.9, pp.548-56, 2013. ,
Targeting the AAA ATPase p97 as an Approach to Treat Cancer through Disruption of Protein Homeostasis, Cancer Cell, vol.28, issue.5, pp.653-65, 2015. ,
The hallmarks of cancer, Cell, vol.100, issue.1, 2000. ,
ER stress and the hallmarks of cancer, Trends in Cancer, vol.5, pp.252-262, 2016. ,
GTPasemediated regulation of the unfolded protein response in Caenorhabditis elegans is dependent on the AAA+ ATPase CDC-48, Mol Cell Biol, vol.28, issue.13, pp.4261-74, 2008. ,
Endoplasmic reticulum stress induction of the Grp78/BiP promoter: activating mechanisms mediated by YY1 and its interactive chromatin modifiers, Mol Cell Biol, vol.25, issue.11, pp.4529-4569, 2005. ,
Transcriptional induction of GRP78/BiP by histone deacetylase inhibitors and resistance to histone deacetylase inhibitor-induced apoptosis, Mol Cancer Ther, vol.8, issue.5, pp.1086-94, 2009. ,
Roles of sumoylation of a reptin chromatin-remodelling complex in cancer metastasis, Nat Cell Biol, vol.8, issue.6, pp.631-640, 2006. ,
Pathogenic Mutations in the Valosincontaining Protein/p97(VCP) N-domain Inhibit the SUMOylation of VCP and Lead to Impaired Stress Response, J Biol Chem, vol.291, issue.27, pp.14373-84, 2016. ,
Hedgehog pathway and GLI1 isoforms in human cancer, Discov Med, vol.13, issue.69, pp.105-118, 2012. ,
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, Cooperative E-box regulation of human GLI1 by TWIST and USF, Genesis, vol.32, issue.4, pp.247-58, 2002.
Regulation of VCP/p97 demonstrates the critical balance between cell death and epithelial-mesenchymal transition (EMT) downstream of ER stress, Oncotarget, vol.6, pp.17725-17762, 2015. ,
, Antagonistic IRE1 RNase functions dictate glioblastoma tumor development
, Néstor Pallares-Lupon, vol.7
, John B. Patterson, vol.9