, Kinetic feasibility of nitroxyl reduction by physiological reductants and biological implications. Free Radic, Biol. Med, vol.47, pp.1130-1139, 2009.
, The biological lifetime of nitric oxide: implications for the perivascular dynamics of NO and O2, Proc. Natl. Acad. Sci. U. S. A, vol.98, pp.355-360, 2001.
, A Tutorial on the Diffusibility and Reactivity of Free Nitric Oxide, Nitric Oxide, vol.1, pp.18-30, 1997.
, Proteins and lipids define the diffusional field of nitric oxide, Am. J. Physiol. Lung Cell. Mol. Physiol, vol.281, pp.904-912, 2001.
, Nitric oxide and peroxynitrite in health and disease, Physiol. Rev, vol.87, pp.315-424, 2007.
, Nitric oxide: a brief overview of chemical and physical properties relevant to therapeutic applications, Future Sci. OA, vol.1, p.59, 2015.
, The biological lifetime of nitric oxide: Implications for the perivascular dynamics of NO and O2, Proc. Natl. Acad. Sci, vol.98, pp.355-360, 2001.
, Breathing new life into nitric oxide signaling: A brief overview of the interplay between oxygen and nitric oxide, Redox Biol, vol.5, pp.225-233, 2015.
, Nitric oxide, superoxide, and peroxynitrite: the good, the bad, and ugly, Am. J. Physiol, vol.271, pp.1424-1437, 1996.
, Biological nitric oxide signalling: chemistry and terminology, Br. J. Pharmacol, vol.169, pp.1417-1429, 2013.
, The oxidative and nitrosative chemistry of the nitric oxide/superoxide reaction in the presence of bicarbonate, Arch. Biochem. Biophys, vol.365, pp.92-100, 1999.
, Structure and regulation of soluble guanylate cyclase, Annu. Rev. Biochem, vol.81, pp.533-559, 2012.
, Modulation by nitric oxide of metalloprotein regulatory activities, BioEssays News Rev. Mol. Cell. Dev. Biol, vol.18, pp.549-556, 1996.
, Trapping of nitric oxide produced during denitrification by extracellular hemoglobin, J. Biol. Chem, vol.263, pp.2316-2323, 1988.
, The Interconversion of Nucleic Acid Bases by Iron(III) Porphyrins and Nitric Oxide, J. Org. Chem, vol.59, pp.4051-4052, 1994.
, Mammalian synthesis of nitrite, nitrate, nitric oxide, and N-nitrosating agents, Chem. Res. Toxicol, vol.1, pp.249-257, 1988.
, Peroxynitrite-mediated nitration of the stable free radical tyrosine residue of the ribonucleotide reductase small subunit, Biochemistry (Mosc.), vol.39, pp.4640-4648, 2000.
, Nitric oxide: a radical molecule in quest of free radicals in proteins, Cell. Mol. Life Sci. CMLS, vol.55, pp.1054-1067, 1999.
, Role of nitrative and oxidative DNA damage in inflammation-related carcinogenesis, J. Biomed. Biotechnol, vol.2012, p.623019, 2012.
, S-nitrosylation: a potential new paradigm in signal transduction, Cardiovasc. Res, vol.62, pp.43-52, 2004.
, Physiology or Medicine for 1998Press Release, p.8, 2017.
, The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine, Nature, vol.288, pp.373-376, 1980.
, Nitric oxide activates guanylate cyclase and increases guanosine 3':5'-cyclic monophosphate levels in various tissue preparations, Proc. Natl. Acad. Sci. U. S. A, vol.74, pp.3203-3207, 1977.
, Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor, Nature, vol.327, pp.524-526, 1987.
, Endothelium-derived relaxing factor produced and released from artery and vein is nitric oxide, Proc. Natl. Acad. Sci. U. S. A, vol.84, pp.9265-9269, 1987.
, Nitric oxide synthases: structure, function and inhibition, Biochem. J, vol.357, pp.593-615, 2001.
, Estrogen modulation of endothelial nitric oxide synthase, Endocr. Rev, vol.23, pp.665-686, 2002.
, Heat-induced increases in endothelial NO synthase expression and activity and endothelial NO release, Am. J. Physiol. Heart Circ. Physiol, vol.285, pp.333-340, 2003.
, Training induces nonuniform increases in eNOS content along the coronary arterial tree, J. Appl. Physiol. Bethesda Md, vol.90, pp.501-510, 1985.
, Increased blood flow causes coordinated upregulation of arterial eNOS and biosynthesis of tetrahydrobiopterin, Am. J. Physiol. Heart Circ. Physiol, vol.290, pp.786-793, 2006.
, The physiological expression of inducible nitric oxide synthase (iNOS) in the human colon, J. Clin. Pathol, vol.54, pp.293-297, 2001.
, Constitutive and inducible nitric oxide synthase gene expression, regulation, and activity in human lung epithelial cells, Proc. Natl. Acad. Sci. U. S. A, vol.91, pp.10089-10093, 1994.
, Distribution of nitric oxide synthase in normal and cirrhotic human liver, Proc. Natl. Acad. Sci. U. S. A, vol.99, pp.17161-17166, 2002.
, Subcellular and cellular locations of nitric oxide synthase isoforms as determinants of health and disease. Free Radic, Biol. Med, vol.49, pp.307-316, 2010.
, Nitric oxide regulates the heart by spatial confinement of nitric oxide synthase isoforms, Nature, vol.416, pp.337-339, 2002.
, Monomeric inducible nitric oxide synthase localizes to peroxisomes in hepatocytes, Proc. Natl. Acad. Sci. U. S. A, vol.102, pp.13837-13842, 2005.
, Epithelial inducible nitric-oxide synthase is an apical EBP50-binding protein that directs vectorial nitric oxide output, J. Biol. Chem, vol.277, pp.33132-33138, 2002.
, Subcellular targeting and trafficking of nitric oxide synthases, Biochem. J, vol.396, pp.401-409, 2006.
URL : https://hal.archives-ouvertes.fr/hal-01478372
, Subcellular localization and characterization of neuronal nitric oxide synthase, J. Neurochem, vol.62, pp.1524-1529, 1994.
, Differential binding of calmodulin domains to constitutive and inducible nitric oxide synthase enzymes, Biochemistry (Mosc.), vol.46, pp.8288-8300, 2007.
, Regulation of endothelium-derived nitric oxide production by the protein kinase Akt, Nature, vol.399, pp.597-601, 1999.
, Structural elements contribute to the calcium/calmodulin dependence on enzyme activation in human endothelial nitric-oxide synthase, J. Biol. Chem, vol.278, pp.52392-52400, 2003.
, The C termini of constitutive nitric-oxide synthases control electron flow through the flavin and heme domains and affect modulation by calmodulin, J. Biol. Chem, vol.275, pp.29225-29232, 2000.
, Structure of Nitric Oxide Synthase Oxygenase Dimer with Pterin and Substrate, Science, vol.279, p.2121, 1998.
, Structural characterization of nitric oxide synthase isoforms reveals striking active-site conservation, Nat. Struct. Biol, vol.6, pp.233-242, 1999.
, Structural analysis of porcine brain nitric oxide synthase reveals a role for tetrahydrobiopterin and L-arginine in the formation of an SDS-resistant dimer, EMBO J, vol.14, pp.3687-3695, 1995.
, Crystal structure of constitutive endothelial nitric oxide synthase: a paradigm for pterin function involving a novel metal center, Cell, vol.95, pp.939-950, 1998.
, Role of bound zinc in dimer stabilization but not enzyme activity of neuronal nitric-oxide synthase, J. Biol. Chem, vol.275, pp.35786-35791, 2000.
, Mammalian nitric oxide synthases, Biochim. Biophys. Acta, vol.1411, pp.217-230, 1999.
, Domain swapping in inducible nitric-oxide synthase. Electron transfer occurs between flavin and heme groups located on adjacent subunits in the dimer, J. Biol. Chem, vol.273, pp.18950-18958, 1998.
, Calmodulin activates intersubunit electron transfer in the neuronal nitric-oxide synthase dimer, J. Biol. Chem, vol.276, pp.23349-23356, 2001.
, Tetrahydrobiopterin in nitric oxide synthase, IUBMB Life, vol.65, pp.358-365, 2013.
, Recent advances in arginine metabolism, Curr. Opin. Clin. Nutr. Metab. Care, vol.7, pp.45-51, 2004.
, The DDAH/ADMA/NOS pathway, Atheroscler, vol.4, pp.33-40, 2003.
, Mechanism of superoxide generation by neuronal nitric-oxide synthase, J. Biol. Chem, vol.274, pp.9573-9580, 1999.
, Nitric oxide inhibition of respiration involves both competitive (heme) and noncompetitive (copper) binding to cytochrome c oxidase, Proc. Natl. Acad. Sci. U. S. A, vol.103, pp.708-713, 2006.
, Post-translational control of endothelial nitric oxide synthase: why isn't calcium/calmodulin enough?, J. Pharmacol. Exp. Ther, vol.299, pp.818-824, 2001.
, The chemical biology of nitric oxide: implications in cellular signaling. Free Radic, Biol. Med, vol.45, pp.18-31, 2008.
, Hypoxic inducible factor 1alpha, extracellular signal-regulated kinase, and p53 are regulated by distinct threshold concentrations of nitric oxide, Proc. Natl. Acad. Sci. U. S. A, vol.101, pp.8894-8899, 2004.
, NO, and NO-donation by S-nitrosothiols: implications for regulation of physiological functions by S-nitrosylation and acceleration of disulfide formation, Arch. Biochem. Biophys, vol.318, pp.279-285, 1995.
, S-nitrosation of arginase 1 requires direct interaction with inducible nitric oxide synthase, Mol. Cell. Biochem, vol.355, pp.83-89, 2011.
, Activation of cytosolic phospholipase A2alpha through nitric oxide-induced S-nitrosylation. Involvement of inducible nitric-oxide synthase and cyclooxygenase-2, J. Biol. Chem, vol.283, pp.3077-3087, 2008.
, S-nitrosylation of proteins: a new insight into endothelial cell function regulated by eNOS-derived NO, Nitric Oxide Biol. Chem, vol.25, pp.95-101, 2011.
, Effects of S-nitrosation of nitric oxide synthase, Advances in Experimental Biology, vol.1, pp.151-456, 2007.
, GAPDH mediates nitrosylation of nuclear proteins, Nat. Cell Biol, vol.12, pp.1094-1100, 2010.
, Target-selective protein S-nitrosylation by sequence motif recognition, Cell, vol.159, pp.623-634, 2014.
, Mechanisms of S-nitrosothiol formation and selectivity in nitric oxide signaling, Curr. Opin. Chem. Biol, vol.16, pp.498-506, 2012.
, Thioredoxin and lipoic acid catalyze the denitrosation of low molecular weight and protein S-nitrosothiols, J. Am. Chem. Soc, vol.127, pp.15815-15823, 2005.
, Nitric oxide and the thioredoxin system: a complex interplay in redox regulation, Biochim. Biophys. Acta, vol.1850, pp.2476-2484, 2015.
, A substrate trapping approach identifies proteins regulated by reversible S-nitrosylation, Mol. Cell. Proteomics MCP, vol.13, pp.2573-2583, 2014.
, Nitrosothiol-Trapping-Based Proteomic Analysis of S-Nitrosylation in Human Lung Carcinoma Cells, PloS One, vol.12, p.169862, 2017.
, Detection of protein S-nitrosylation with the biotin-switch technique. Free Radic, Biol. Med, vol.46, pp.119-126, 2009.
, The SNO-proteome: causation and classifications, Curr. Opin. Chem. Biol, vol.15, pp.129-136, 2011.
, Inhibition of NF-kappaB DNA binding by nitric oxide, Nucleic Acids Res, vol.24, pp.2236-2242, 1996.
, Nitric oxide impairs normoxic degradation of HIF-1alpha by inhibition of prolyl hydroxylases, Mol. Biol. Cell, vol.14, pp.3470-3481, 2003.
, S-nitrosation of Cys-800 of HIF-1alpha protein activates its interaction with p300 and stimulates its transcriptional activity, FEBS Lett, vol.549, pp.105-109, 2003.
, Zinc finger proteins as molecular targets for nitric oxide-mediated gene regulation, Antioxid. Redox Signal, vol.3, pp.565-575, 2001.
, S-nitrosylation of matrix metalloproteinases: signaling pathway to neuronal cell death, Science, vol.297, pp.1186-1190, 2002.
, Nitric oxide activates or inhibits skeletal muscle ryanodine receptors depending on its concentration, membrane potential and ligand binding, J. Membr. Biol, vol.173, pp.227-236, 2000.
, Regulation by S-nitrosylation of protein post-translational modification, J. Biol. Chem, vol.287, pp.4411-4418, 2012.
, Peroxynitrite-induced mutation spectra of pSP189 following replication in bacteria and in human cells, Mutat. Res, vol.349, pp.51-61, 1996.
, Nanomolar concentrations of nitric oxide reversibly inhibit synaptosomal respiration by competing with oxygen at cytochrome oxidase, FEBS Lett, vol.356, pp.295-298, 1994.
, Persistent inhibition of cell respiration by nitric oxide: crucial role of S-nitrosylation of mitochondrial complex I and protective action of glutathione, Proc. Natl. Acad. Sci. U. S. A, vol.95, pp.7631-7636, 1998.
, Nitric oxide as a modulator of apoptosis, Cancer Lett, vol.226, pp.1-15, 2005.
, Nitric oxide (NO): an effector of apoptosis, Cell Death Differ, vol.6, pp.969-975, 1999.
, Mechanism of nitric oxide-induced apoptosis in human neuroblastoma SH-SY5Y cells, FEBS Lett, vol.484, pp.253-260, 2000.
, Caspase activation and cytochrome c release during HL-60 cell apoptosis induced by a nitric oxide donor, Free Radic. Res, vol.32, pp.507-514, 2000.
, Apoptotic signaling pathways induced by nitric oxide in human lymphoblastoid cells expressing wild-type or mutant p53, Cancer Res, vol.64, pp.3022-3029, 2004.
, Mechanisms of hepatoprotection by nitric oxide, Ann. N. Y. Acad. Sci, vol.962, pp.415-422, 2002.
, Autocrine nitric oxide modulates CD95-induced apoptosis in gammadelta T lymphocytes, J. Biol. Chem, vol.272, pp.23211-23215, 1997.
, Nitric oxide inhibits stress-induced endothelial cell apoptosis, Crit. Care Med, vol.26, pp.1500-1509, 1998.
, Nitric oxide protects PC12 cells from serum deprivation-induced apoptosis by cGMP-dependent inhibition of caspase signaling, J. Neurosci. Off. J. Soc. Neurosci, vol.19, pp.6740-6747, 1999.
, Superoxide formation and macrophage resistance to nitric oxide-mediated apoptosis, J. Biol. Chem, vol.272, pp.7253-7258, 1997.
, Nrf2 signaling in coordinated activation of antioxidant gene expression. Free Radic, Biol. Med, vol.36, pp.1199-1207, 2004.
, The Keap1-Nrf2 system as an in vivo sensor for electrophiles, Nitric Oxide Biol. Chem, vol.25, pp.153-160, 2011.
, Scaffolding of Keap1 to the actin cytoskeleton controls the function of Nrf2 as key regulator of cytoprotective phase 2 genes, Proc. Natl. Acad. Sci. U. S. A, vol.101, pp.2046-2051, 2004.
, Nrf2-Keap1 defines a physiologically important stress response mechanism, Trends Mol. Med, vol.10, pp.549-557, 2004.
, Sulforaphane suppressed LPS-induced inflammation in mouse peritoneal macrophages through Nrf2 dependent pathway, Biochem. Pharmacol, vol.76, pp.967-973, 2008.
, Curcumin induces heme oxygenase 1 through generation of reactive oxygen species, p38 activation and phosphatase inhibition, Int. J. Mol. Med, vol.19, pp.165-172, 2007.
, Involvement of Nrf2, p38, B-Raf, and nuclear factor-kappaB, but not phosphatidylinositol 3-kinase, in induction of hemeoxygenase-1 by dietary polyphenols, Mol. Pharmacol, vol.69, pp.1033-1040, 2006.
, Phosphorylation of Nrf2 at Ser40 by protein kinase C in response to antioxidants leads to the release of Nrf2 from INrf2, but is not required for Nrf2 stabilization/accumulation in the nucleus and transcriptional activation of antioxidant response element-mediated NAD(P)H:quinone oxidoreductase-1 gene expression, J. Biol. Chem, vol.278, pp.44675-44682, 2003.
, Protection against electrophile and oxidant stress by induction of the phase 2 response: fate of cysteines of the Keap1 sensor modified by inducers, Proc. Natl. Acad. Sci. U. S. A, vol.101, pp.2040-2045, 2004.
, Oxidative and electrophilic stresses activate Nrf2 through inhibition of ubiquitination activity of Keap1, Mol. Cell. Biol, vol.26, pp.221-229, 2006.
, S-nitrosylation of PTEN Invovled in ischemic brain injury in rat hippocampal CA1 region, Neurochem. Res, vol.34, pp.1507-1512, 2009.
, The critical role of nitric oxide signaling, via protein S-guanylation and nitrated cyclic GMP, in the antioxidant adaptive response, J. Biol. Chem, vol.285, pp.23970-23984, 2010.
, Nitric oxide activates Nrf2 through Snitrosylation of Keap1 in PC12 cells, Nitric Oxide Biol. Chem, vol.25, pp.161-168, 2011.
, Positive or negative MAREdependent transcriptional regulation is determined by the abundance of small Maf proteins, Cell, vol.103, pp.865-875, 2000.
, Nitric oxide synthases: regulation and function, Eur. Heart J, vol.33, pp.829-837, 2012.
, Hypertension in mice lacking the gene for endothelial nitric oxide synthase, Nature, vol.377, pp.239-242, 1995.
, Vascular nitric oxide: Beyond eNOS, J. Pharmacol. Sci, vol.129, pp.83-94, 2015.
, EDRF coordinates the behaviour of vascular resistance vessels, Nature, vol.329, pp.442-445, 1987.
, Peroxynitrite modification of low-density lipoprotein leads to recognition by the macrophage scavenger receptor, FEBS Lett, vol.330, pp.181-185, 1993.
, Extensive nitration of protein tyrosines in human atherosclerosis detected by immunohistochemistry, Biol. Chem. Hoppe. Seyler, vol.375, pp.81-88, 1994.
, Nitric oxide modulates the expression of monocyte chemoattractant protein 1 in cultured human endothelial cells, Circ. Res, vol.76, pp.980-986, 1995.
, Nitric oxide: an endogenous modulator of leukocyte adhesion, Proc. Natl. Acad. Sci. U. S. A, vol.88, pp.4651-4655, 1991.
, Endothelium-derived relaxing factor from cultured human endothelial cells inhibits aggregation of human platelets, Thromb. Res, vol.47, pp.561-571, 1987.
, Direct evidence for the importance of endothelium-derived nitric oxide in vascular remodeling, J. Clin. Invest, vol.101, pp.731-736, 1998.
, Essential role of endothelial nitric oxide synthase for mobilization of stem and progenitor cells, Nat. Med, vol.9, pp.1370-1376, 2003.
, Significance of nitric oxide synthases: Lessons from triple nitric oxide synthases null mice, J. Pharmacol. Sci, vol.127, pp.42-52, 2015.
, Oxidation of tetrahydrobiopterin leads to uncoupling of endothelial cell nitric oxide synthase in hypertension, J. Clin. Invest, vol.111, pp.1201-1209, 2003.
, Oxidation of the zinc-thiolate complex and uncoupling of endothelial nitric oxide synthase by peroxynitrite, J. Clin. Invest, vol.109, pp.817-826, 2002.
, Role of neutral amino acid transport and protein breakdown for substrate supply of nitric oxide synthase in human endothelial cells, Circ. Res, vol.93, pp.813-820, 2003.
, Increased arginase II and decreased NO synthesis in endothelial cells of patients with pulmonary arterial hypertension, FASEB J. Off. Publ. Fed. Am. Soc. Exp. Biol, vol.18, pp.1746-1748, 2004.
, Association of plasma asymmetrical dimethylarginine (ADMA) with elevated vascular superoxide production and endothelial nitric oxide synthase uncoupling: implications for endothelial function in human atherosclerosis, Eur. Heart J, vol.30, pp.1142-1150, 2009.
, S-glutathionylation uncouples eNOS and regulates its cellular and vascular function, Nature, vol.468, pp.1115-1118, 2010.
, Role of nitric oxide in shock: the large animal perspective, Front. Biosci. Landmark Ed, vol.14, 1979.
, Models of the diffusional spread of nitric oxide: implications for neural nitric oxide signalling and its pharmacological properties, Neuropharmacology, vol.33, pp.1235-1244, 1994.
, Nitric Oxide Contribution in the CNS | Cayman Chemical, p.15, 2017.
, Nitric oxide neurons and neurotransmission, Prog. Neurobiol, vol.90, pp.246-255, 2010.
, Why is nitric oxide important for our brain?, Funct. Neurol, vol.30, pp.159-163, 2015.
, Tests of the roles of two diffusible substances in long-term potentiation: evidence for nitric oxide as a possible early retrograde messenger, Proc. Natl. Acad. Sci. U. S. A, vol.88, pp.11285-11289, 1991.
, Nitric oxide and long-term synaptic depression in the rat hippocampus, Neuroreport, vol.4, pp.1131-1134, 1993.
, Altered synaptic plasticity and memory formation in nitric oxide synthase inhibitor-treated rats, Proc. Natl. Acad. Sci. U. S. A, vol.90, pp.9191-9194, 1993.
, An inhibitor of nitric oxide synthesis prevents memory formation in the chick, Neurosci. Lett, vol.145, pp.165-167, 1992.
, Neuronal Nitric Oxide Synthase in Vascular Physiology and Diseases, Front. Physiol, vol.7, p.206, 2016.
, Nitric oxide as a mediator of relaxation of the corpus cavernosum in response to nonadrenergic, noncholinergic neurotransmission, N. Engl. J. Med, vol.326, pp.90-94, 1992.
, Nitric oxide signaling in brain function, dysfunction, and dementia, Neurosci. Rev. J. Bringing Neurobiol. Neurol. Psychiatry, vol.16, pp.435-452, 2010.
, Inflammatory neurodegeneration and mechanisms of microglial killing of neurons, Mol. Neurobiol, vol.41, pp.242-247, 2010.
, Pharmacological characterization of the nitrergic innervation of the stomach, vol.64, pp.151-166, 2002.
, L-arginine is required for expression of the activated macrophage effector mechanism causing selective metabolic inhibition in target cells, J. Immunol. Baltim. Md, vol.138, pp.550-565, 1950.
, Macrophage cytotoxicity: role for L-arginine deiminase and imino nitrogen oxidation to nitrite, Science, vol.235, pp.473-476, 1987.
, M-1/M-2 macrophages and the Th1/Th2 paradigm, J. Immunol. Baltim. Md, vol.164, pp.6166-6173, 1950.
, Macrophage plasticity and polarization: in vivo veritas, J. Clin. Invest, vol.122, pp.787-795, 2012.
, Alternative activation of macrophages: mechanism and functions, Immunity, vol.32, pp.593-604, 2010.
, Macrophage plasticity and interaction with lymphocyte subsets: cancer as a paradigm, Nat. Immunol, vol.11, pp.889-896, 2010.
, Macrophage activation and polarization: nomenclature and experimental guidelines, Immunity, vol.41, pp.14-20, 2014.
, Nitric oxide synthase in innate and adaptive immunity: an update, Trends Immunol, vol.36, pp.161-178, 2015.
, Multiple targets of nitric oxide in the tricarboxylic acid cycle of Salmonella enterica serovar typhimurium, Cell Host Microbe, vol.10, pp.33-43, 2011.
, Host S-nitrosylation inhibits clostridial small molecule-activated glucosylating toxins, Nat. Med, vol.17, pp.1136-1141, 2011.
, Collective nitric oxide production provides tissue-wide immunity during Leishmania infection, J. Clin. Invest, vol.124, pp.1711-1722, 2014.
, Photoconvertible pathogen labeling reveals nitric oxide control of Leishmania major infection in vivo via dampening of parasite metabolism, Cell Host Microbe, vol.14, pp.460-467, 2013.
, Stimulation of inducible nitric oxide synthase expression by beta interferon increases necrotic death of macrophages upon Listeria monocytogenes infection, Infect. Immun, vol.76, pp.1649-1656, 2008.
, Interferon gamma activated macrophages kill mycobacteria by nitric oxide induced apoptosis, PloS One, vol.6, p.19105, 2011.
, Nitric oxide-mediated regulation of ferroportin-1 controls macrophage iron homeostasis and immune function in Salmonella infection, J. Exp. Med, vol.210, pp.855-873, 2013.
, Plasmodium falciparum evades mosquito immunity by disrupting JNK-mediated apoptosis of invaded midgut cells, Proc. Natl. Acad. Sci. U. S. A, vol.112, pp.1273-1280, 2015.
, Regulation of lymphocytes by nitric oxide, Methods Mol. Biol. Clifton NJ, vol.677, pp.375-393, 2011.
, Regulation of immune responses by L-arginine metabolism, Nat. Rev. Immunol, vol.5, pp.641-654, 2005.
, Nitric oxide preferentially induces type 1 T cell differentiation by selectively up-regulating IL-12 receptor beta 2 expression via cGMP, Proc. Natl. Acad. Sci. U. S. A, vol.99, pp.16186-16191, 2002.
, Nitric oxide enhances Th9 cell differentiation and airway inflammation, Nat. Commun, vol.5, p.4575, 2014.
, T cell-derived inducible nitric oxide synthase switches off Th17 cell differentiation, J. Exp. Med, vol.210, pp.1447-1462, 2013.
, Induction and stability of human Th17 cells require endogenous NOS2 and cGMP-dependent NO signaling, J. Exp. Med, vol.210, pp.1433-1445, 2013.
, iNOS expression in CD4+ T cells limits Treg induction by repressing TGF?1: combined iNOS inhibition and Treg depletion unmask endogenous antitumor immunity, Clin. Cancer Res. Off. J. Am. Assoc. Cancer Res, vol.20, pp.6439-6451, 2014.
, Spotlights on immunological effects of reactive nitrogen species: When inflammation says nitric oxide, World J. Exp. Med, vol.5, pp.64-76, 2015.
, Nitric oxide regulates BAFF expression and T cell-independent antibody responses, J. Immunol. Baltim. Md, pp.1110-1120, 2014.
, Nitric oxide produced by murine dendritic cells is cytotoxic for intracellular Salmonella enterica sv, Typhimurium. Scand. J. Immunol, vol.58, pp.493-502, 2003.
, TNF/iNOS-producing dendritic cells are the necessary evil of lethal influenza virus infection, Proc. Natl. Acad. Sci. U. S. A, vol.106, pp.5306-5311, 2009.
, iNOS-producing inflammatory dendritic cells constitute the major infected cell type during the chronic Leishmania major infection phase of C57BL/6 resistant mice, PLoS Pathog, vol.5, p.1000494, 2009.
URL : https://hal.archives-ouvertes.fr/hal-00591434
, Oxidative post-translational modifications and their involvement in the pathogenesis of autoimmune diseases, Redox Biol, vol.2, pp.715-724, 2014.
, Cutting edge: MHC class II-restricted peptides containing the inflammation-associated marker 3-nitrotyrosine evade central tolerance and elicit a robust cell-mediated immune response, J. Immunol. Baltim. Md, vol.171, pp.528-532, 1950.
, Immunogenicity of autologous IgG bearing the inflammation-associated marker 3-nitrotyrosine, Immunol. Lett, vol.96, pp.47-54, 2005.
, Reactive oxygen species expose cryptic epitopes associated with autoimmune goodpasture syndrome, J. Biol. Chem, vol.275, 2000.
, Pneumococcal vaccination decreases atherosclerotic lesion formation: molecular mimicry between Streptococcus pneumoniae and oxidized LDL, Nat. Med, vol.9, pp.736-743, 2003.
, Prevalence of anti-3-nitrotyrosine antibodies in the joint synovial fluid of patients with rheumatoid arthritis, osteoarthritis and systemic lupus erythematosus, Clin. Chim. Acta Int. J. Clin. Chem, vol.370, pp.100-107, 2006.
, 3-Nitrotyrosine: A biomarker of nitrogen free radical species modified proteins in systemic autoimmunogenic conditions, Hum. Immunol, vol.74, pp.1392-1399, 2013.
, Potential role of nitric oxide in a model of chronic colitis in rhesus macaques, Gastroenterology, vol.108, pp.705-711, 1995.
, Inflammation and cancer: back to Virchow?, Lancet Lond. Engl, vol.357, pp.539-545, 2001.
, Mechanisms linking pathogens-associated inflammation and cancer, Cancer Lett, vol.305, pp.250-262, 2011.
, Accessories to the crime: functions of cells recruited to the tumor microenvironment, Cancer Cell, vol.21, pp.309-322, 2012.
, Tumor-associated macrophages (TAM) as major players of the cancer-related inflammation, J. Leukoc. Biol, vol.86, pp.1065-1073, 2009.
, Chemokine nitration prevents intratumoral infiltration of antigen-specific T cells, J. Exp. Med, vol.208, pp.1949-1962, 2011.
, Macrophage-derived nitric oxide regulates T cell activation via reversible disruption of the Jak3/STAT5 signaling pathway, J. Immunol. Baltim. Md, vol.160, pp.5729-5734, 1950.
, The yin and yang of nitric oxide in cancer progression, Carcinogenesis, vol.34, pp.503-512, 2013.
, Nitric oxide and cancer: a review, World J. Surg. Oncol, vol.11, p.118, 2013.
, Regulation of STAT3 and NF-?B activations by S-nitrosylation in multiple myeloma. Free Radic, Biol. Med, vol.106, pp.245-253, 2017.
, Nitric oxide synthase inhibitors: a review of patents from 2011 to the present, Expert Opin. Ther. Pat, vol.25, pp.49-68, 2015.
, S-Nitrosothiols as Platforms for Topical Nitric Oxide Delivery, Basic Clin. Pharmacol. Toxicol, vol.119, pp.49-56, 2016.
, Nitric oxide and cancer therapy: the emperor has NO clothes, Curr. Pharm. Des, vol.16, pp.381-391, 2010.
, S-Nitrosylation in Cancer Cells: To Prevent or to Cause? in Nitric Oxide and Cancer: Pathogenesis and Therapy, pp.97-109, 2015.
, Regulation of the expression of inducible nitric oxide synthase, Nitric Oxide Biol. Chem, vol.23, pp.75-93, 2010.
, Transcriptional basis for hyporesponsiveness of the human inducible nitric oxide synthase gene to lipopolysaccharide/interferon-gamma, J. Leukoc. Biol, vol.59, pp.575-585, 1996.
, Epigenetic silencing of the human NOS2 gene: rethinking the role of nitric oxide in human macrophage inflammatory responses, J. Immunol. Baltim. Md, pp.2326-2338, 2014.
, Epigenetic basis for the transcriptional hyporesponsiveness of the human inducible nitric oxide synthase gene in vascular endothelial cells, J. Immunol. Baltim. Md, vol.175, pp.3846-3861, 1950.
, Transcriptional regulation of human inducible nitric oxide synthase (NOS2) gene by cytokines: initial analysis of the human NOS2 promoter, Proc. Natl. Acad. Sci. U. S. A, vol.93, pp.1054-1059, 1996.
, Analysis of the cytokinestimulated human inducible nitric oxide synthase (iNOS) gene: characterization of differences between human and mouse iNOS promoters, Biochem. Biophys. Res. Commun, vol.248, pp.871-878, 1998.
, Promoter of the mouse gene encoding calciumindependent nitric oxide synthase confers inducibility by interferon gamma and bacterial lipopolysaccharide, J. Exp. Med, vol.177, pp.1779-1784, 1993.
, Inhibition by costunolide of phorbol ester-induced transcriptional activation of inducible nitric oxide synthase gene in a human monocyte cell line THP-1, Cancer Lett, vol.164, pp.7-13, 2001.
, Transcriptional regulation of the human iNOS gene in vascular-smooth-muscle cells and macrophages: evidence for tissue specificity, Biochem. Biophys. Res. Commun, vol.220, pp.600-605, 1996.
, Identification of conserved domains in the promoter regions of nitric oxide synthase 2: implications for the species-specific transcription and evolutionary differences, BMC Genomics, vol.8, p.271, 2007.
, Molecular regulation of the human inducible nitric oxide synthase (iNOS) gene, Shock Augusta Ga, vol.13, pp.413-424, 2000.
, A short tandem repeat polymorphism in the inducible nitric oxide synthase gene in Chinese population
, Yi Chuan Xue Bao, vol.29, pp.290-293, 2002.
, Survey of the allelic frequency of a NOS2A promoter microsatellite in human populations: assessment of the NOS2A gene and predisposition to infectious disease, Nitric Oxide Biol. Chem, vol.4, pp.379-383, 2000.
, In vivo footprinting of the mouse inducible nitric oxide synthase gene: inducible protein occupation of numerous sites including Oct and NF-IL6, Nucleic Acids Res, vol.24, pp.1682-1687, 1996.
, Role of transcription factor NF-kappa B/Rel in induction of nitric oxide synthase, J. Biol. Chem, vol.269, pp.4705-4708, 1994.
, Multiple NF-kappaB enhancer elements regulate cytokine induction of the human inducible nitric oxide synthase gene, J. Biol. Chem, vol.273, pp.15148-15156, 1998.
, Nonconventional initiation complex assembly by STAT and NF-kappaB transcription factors regulates nitric oxide synthase expression, Immunity, vol.33, pp.25-34, 2010.
, Cytokine induction of NO synthase II in human DLD-1 cells: roles of the JAKSTAT, AP-1 and NF-kappaB-signaling pathways, Br. J. Pharmacol, vol.125, pp.193-201, 1998.
, Identification of a classic cytokine-induced enhancer upstream in the human iNOS promoter, FASEB J. Off. Publ. Fed. Am. Soc. Exp. Biol, vol.21, pp.535-542, 2007.
, Toll-like receptor activation and hypoxia use distinct signaling pathways to stabilize hypoxia-inducible factor 1? (HIF1A) and result in differential HIF1A-dependent gene expression, J. Leukoc. Biol, vol.90, pp.551-562, 2011.
, Ihrig-Biedert, I. & Förstermann, U. Glucocorticoids inhibit the induction of nitric oxide synthase II by down-regulating cytokine-induced activity of transcription factor nuclear factor-kappa B, Mol. Pharmacol, vol.49, pp.15-21, 1996.
, A repressor in the proximal human inducible nitric oxide synthase promoter modulates transcriptional activation, FASEB J. Off. Publ. Fed. Am. Soc. Exp. Biol, vol.16, pp.631-633, 2002.
, Involvement of KSRP in the post-transcriptional regulation of human iNOS expression-complex interplay of KSRP with TTP and HuR, Nucleic Acids Res, vol.33, pp.4813-4827, 2005.
, Similar regulation of human inducible nitric-oxide synthase expression by different isoforms of the RNA-binding protein AUF1, J. Biol. Chem, vol.284, pp.2755-2766, 2009.
, miRNA-939 regulates human inducible nitric oxide synthase posttranscriptional gene expression in human hepatocytes, Proc. Natl. Acad. Sci. U. S. A, vol.109, pp.5826-5831, 2012.
, NPM-ALK up-regulates iNOS expression through a STAT3/microRNA-26a-dependent mechanism, J. Pathol, vol.230, pp.82-94, 2013.
, Caveolin-1 downregulates inducible nitric oxide synthase via the proteasome pathway in human colon carcinoma cells, Proc. Natl. Acad. Sci. U. S. A, vol.97, pp.14334-14339, 2000.
, Caveolin-1-mediated post-transcriptional regulation of inducible nitric oxide synthase in human colon carcinoma cells, Biol. Res, vol.35, pp.169-176, 2002.
, Src-mediated phosphorylation regulates subcellular distribution and activity of human inducible nitric oxide synthase, Oncogene, vol.25, pp.198-206, 2006.
, Inducible nitric-oxide synthase is regulated by the proteasome degradation pathway, J. Biol. Chem, vol.276, pp.24268-24273, 2001.
, Ubiquitination of inducible nitric oxide synthase is required for its degradation, Proc. Natl. Acad. Sci. U. S. A, vol.99, pp.12315-12320, 2002.
, The ECS(SPSB) E3 ubiquitin ligase is the master regulator of the lifetime of inducible nitric-oxide synthase, Biochem. Biophys. Res. Commun, vol.409, pp.46-51, 2011.
, The SPRY domain-containing SOCS box protein SPSB2 targets iNOS for proteasomal degradation, J. Cell Biol, vol.190, pp.129-141, 2010.
, Regulation of inducible nitric-oxide synthase by the SPRY domain-and SOCS boxcontaining proteins, J. Biol. Chem, vol.286, pp.9009-9019, 2011.
, TLR regulation of SPSB1 controls inducible nitric oxide synthase induction, J. Immunol. Baltim. Md, vol.187, pp.3798-3805, 1950.
, A. iNOS regulation by calcium/calmodulin-dependent protein kinase II in vascular smooth muscle, Am. J. Physiol. Heart Circ. Physiol, vol.292, pp.2634-2642, 2007.
URL : https://hal.archives-ouvertes.fr/hal-01520705
, Heat shock protein 90 as an endogenous protein enhancer of inducible nitric-oxide synthase, J. Biol. Chem, vol.278, pp.36953-36958, 2003.
, An inducible nitric-oxide synthase (NOS)-associated protein inhibits NOS dimerization and activity, J. Biol. Chem, vol.274, pp.30250-30257, 1999.
, Kalirin inhibition of inducible nitric-oxide synthase, J. Biol. Chem, vol.274, pp.993-999, 1999.
, TGF-? Family Signaling in the Control of Cell Proliferation and Survival, Cold Spring Harb. Perspect. Biol, vol.9, 2017.
, TGF-?: the master regulator of fibrosis, Nat. Rev. Nephrol, vol.12, pp.325-338, 2016.
, TGF-? activation and function in immunity, Annu. Rev. Immunol, vol.32, pp.51-82, 2014.
, TGF-? signaling and its role in the regulation of hematopoietic stem cells, Syst. Synth. Biol, vol.9, pp.1-10, 2015.
, Regulation of the Immune Response by TGF-?: From Conception to Autoimmunity and Infection, Cold Spring Harb. Perspect. Biol, vol.9, 2017.
, Control of Nitric Oxide Production by Transforming Growth Factor-?1: Mechanistic Insights and Potential Relevance to Human Disease, Nitric Oxide, vol.1, pp.3-17, 1997.
, TGF? signalling in context, Nat. Rev. Mol. Cell Biol, vol.13, pp.616-630, 2012.
, TGF-? Signaling from Receptors to Smads, Cold Spring Harb. Perspect. Biol, vol.8, 2016.
, Signaling Receptors for TGF-? Family Members, Cold Spring Harb. Perspect. Biol, vol.8, 2016.
, Membrane-anchored and soluble forms of betaglycan, a polymorphic proteoglycan that binds transforming growth factor-beta, J. Cell Biol, vol.109, pp.3137-3145, 1989.
, TGF-beta signalling from cell membrane to nucleus through SMAD proteins, Nature, vol.390, pp.465-471, 1997.
, Structural determinants of Smad function in TGF-? signaling, Trends Biochem. Sci, vol.40, pp.296-308, 2015.
, Structural Basis of Intracellular TGF-? Signaling: Receptors and Smads, Cold Spring Harb. Perspect. Biol, vol.8, 2016.
, Identification of Smad7, a TGFbeta-inducible antagonist of TGF-beta signalling, Nature, vol.389, pp.631-635, 1997.
, Regulation of TGF-? Family Signaling by Inhibitory Smads, Cold Spring Harb. Perspect. Biol, vol.9, 2017.
, Analysis of the contribution of receptor subdomains to the cooperative binding and internalization of transforming growth factor-beta (TGF-beta) type I and type II receptors, Exp. Cell Res, vol.314, pp.2553-2568, 2008.
, TGF-? signalling is mediated by two autonomously functioning T?RI:T?RII pairs, EMBO J, vol.30, pp.1263-1276, 2011.
, Specificity and versatility in tgf-beta signaling through Smads, Annu. Rev. Cell Dev. Biol, vol.21, pp.659-693, 2005.
, The L3 loop: a structural motif determining specific interactions between SMAD proteins and TGF-beta receptors, EMBO J, vol.17, pp.996-1005, 1998.
, An extended bipartite nuclear localization signal in Smad4 is required for its nuclear import and transcriptional activity, Oncogene, vol.22, pp.1057-1069, 2003.
, Importin beta mediates nuclear translocation of Smad 3, J. Biol. Chem, vol.275, pp.23425-23428, 2000.
, Smad2 nucleocytoplasmic shuttling by nucleoporins CAN/Nup214 and Nup153 feeds TGFbeta signaling complexes in the cytoplasm and nucleus, Mol. Cell, vol.10, pp.271-282, 2002.
, Transforming growth factor-beta induces nuclear import of Smad3 in an importin-beta1 and Ran-dependent manner, Mol. Biol. Cell, vol.12, pp.1079-1091, 2001.
, The TGFbeta superfamily signaling pathway, Wiley Interdiscip. Rev. Dev. Biol, vol.2, pp.47-63, 2013.
, Smad-mediated regulation of microRNA biosynthesis, FEBS Lett, vol.586, pp.1906-1912, 2012.
, Non-Smad Signaling Pathways of the TGF-? Family, Cold Spring Harb. Perspect. Biol, vol.9, 2017.
, Signal transductions induced by bone morphogenetic protein-2 and transforming growth factor-beta in normal human osteoblastic cells, J. Biol. Chem, vol.277, pp.15514-15522, 2002.
, Transforming growth factor-?1 induces epithelial-to-mesenchymal transition in human lung cancer cells via PI3K/Akt and MEK/Erk1/2 signaling pathways, Mol. Biol. Rep, vol.39, pp.3549-3556, 2012.
, Src phosphorylates Tyr284 in TGF-beta type II receptor and regulates TGF-beta stimulation of p38 MAPK during breast cancer cell proliferation and invasion, Cancer Res, vol.67, pp.3752-3758, 2007.
, The type I TGF-beta receptor engages TRAF6 to activate TAK1 in a receptor kinase-independent manner, Nat. Cell Biol, vol.10, pp.1199-1207, 2008.
, TRAF6 mediates Smad-independent activation of JNK and p38 by TGF-beta, Mol. Cell, vol.31, pp.918-924, 2008.
, Epithelial-mesenchymal transitions in development and disease, Cell, vol.139, pp.871-890, 2009.
, Epithelial to mesenchymal transition in human skin wound healing is induced by tumor necrosis factor-alpha through bone morphogenic protein-2, Am. J. Pathol, vol.176, pp.2247-2258, 2010.
, Signal Transduction Pathways of EMT Induced by TGF-?, SHH, and WNT and Their Crosstalks, J. Clin. Med, vol.5, 2016.
, Cancer as an overhealing wound: an old hypothesis revisited, Nat. Rev. Mol. Cell Biol, vol.9, pp.628-638, 2008.
, Epithelial-mesenchymal transition in cancer: parallels between normal development and tumor progression, J. Mammary Gland Biol. Neoplasia, vol.15, pp.117-134, 2010.
, Cell size and invasion in TGF-beta-induced epithelial to mesenchymal transition is regulated by activation of the mTOR pathway, J. Cell Biol, vol.178, pp.437-451, 2007.
, Central role for Rho in TGF-beta1-induced alpha-smooth muscle actin expression during epithelial-mesenchymal transition, Am. J. Physiol. Renal Physiol, vol.284, pp.911-924, 2003.
, Phosphatidylinositol 3-kinase function is required for transforming growth factor beta-mediated epithelial to mesenchymal transition and cell migration, J. Biol. Chem, vol.275, pp.36803-36810, 2000.
, The role of small GTPases of the Rho/Rac family in TGF?-induced EMT and cell motility in cancer, Dev. Dyn. Off. Publ. Am. Assoc. Anat, 2017.
, Regulation of the Bioavailability of TGF-? and TGF-?-Related Proteins, Cold Spring Harb. Perspect. Biol, vol.8, 2016.
, Association of the small latent transforming growth factorbeta with an eight cysteine repeat of its binding protein LTBP-1, EMBO J, vol.15, pp.245-253, 1996.
, Identification and characterization of an eight-cysteine repeat of the latent transforming growth factor-beta binding protein-1 that mediates bonding to the latent transforming growth factor-beta1, J. Biol. Chem, vol.271, pp.29891-29896, 1996.
, Processing of transforming growth factor beta 1 precursor by human furin convertase, J. Biol. Chem, vol.270, pp.10618-10624, 1995.
, Fibronectin is required for integrin alphavbeta6-mediated activation of latent TGF-beta complexes containing LTBP-1, FASEB J. Off. Publ. Fed. Am. Soc. Exp. Biol, vol.19, pp.1798-1808, 2005.
, Fibronectin regulates latent transforming growth factor-beta (TGF beta) by controlling matrix assembly of latent TGF beta-binding protein-1, J. Biol. Chem, vol.280, pp.18871-18880, 2005.
, Latent transforming growth factor beta-binding protein 1 interacts with fibrillin and is a microfibril-associated protein, J. Biol. Chem, vol.278, pp.2750-2757, 2003.
, Dysregulation of TGF-beta activation contributes to pathogenesis in Marfan syndrome, Nat. Genet, vol.33, pp.407-411, 2003.
, The integrin alpha v beta 6 binds and activates latent TGF beta 1: a mechanism for regulating pulmonary inflammation and fibrosis, Cell, vol.96, pp.319-328, 1999.
, The integrin alpha(v)beta8 mediates epithelial homeostasis through MT1-MMPdependent activation of TGF-beta1, J. Cell Biol, vol.157, pp.493-507, 2002.
, Absence of integrin-mediated TGFbeta1 activation in vivo recapitulates the phenotype of TGFbeta1-null mice, J. Cell Biol, vol.176, pp.787-793, 2007.
, Targeting of ?v integrin identifies a core molecular pathway that regulates fibrosis in several organs, Nat. Med, vol.19, pp.1617-1624, 2013.
, Loss of integrin alpha(v)beta8 on dendritic cells causes autoimmunity and colitis in mice, Nature, vol.449, pp.361-365, 2007.
, Integrin ?v?8-Mediated TGF-? Activation by Effector Regulatory T Cells Is Essential for Suppression of T-Cell-Mediated Inflammation, Immunity, vol.42, pp.903-915, 2015.
, Cell-associated activation of latent transforming growth factor-beta by calpain, J. Cell. Physiol, vol.174, pp.186-193, 1998.
, The role of proteases in transforming growth factor-beta activation, Int. J. Biochem. Cell Biol, vol.40, pp.1068-1078, 2008.
, Physicochemical activation of recombinant latent transforming growth factor-beta's 1, 2, and 3. Growth Factors Chur Switz, vol.3, pp.35-43, 1990.
, Latent transforming growth factor beta1 activation in situ: quantitative and functional evidence after low-dose gamma-irradiation, FASEB J. Off. Publ. Fed. Am. Soc. Exp. Biol, vol.11, pp.991-1002, 1997.
, Transforming growth factorbeta activation in irradiated murine mammary gland, J. Clin. Invest, vol.93, pp.892-899, 1994.
, Redox-mediated activation of latent transforming growth factorbeta 1, Mol. Endocrinol. Baltim. Md, vol.10, pp.1077-1083, 1996.
, In vitro and in vivo evidence for shear-induced activation of latent transforming growth factor-beta1, Blood, vol.112, pp.3650-3660, 2008.
, Endogenous TGF-beta activation by reactive oxygen species is key to Foxp3 induction in TCR-stimulated and HIV-1-infected human CD4+CD25-T cells, Retrovirology, vol.4, p.57, 2007.
, Involvement of UVB-induced reactive oxygen species in TGF-beta biosynthesis and activation in keratinocytes. Free Radic, Biol. Med, vol.38, pp.890-897, 2005.
, Activation of the bone-derived latent TGF beta complex by isolated osteoclasts, Biochem. Biophys. Res. Commun, vol.158, pp.817-823, 1989.
, Acidic cellular environments: activation of latent TGFbeta and sensitization of cellular responses to TGF-beta and EGF, Int. J. Cancer, vol.43, pp.886-891, 1989.
, Macrophage deactivating factor and transforming growth factors-beta 1-beta 2 and-beta 3 inhibit induction of macrophage nitrogen oxide synthesis by IFN-gamma, J. Immunol. Baltim. Md, vol.145, pp.940-944, 1950.
, Autocrine regulation of the production of the gaseous messenger nitric oxide in a glioblastoma cell line, Exp. Cell Res, vol.210, pp.137-139, 1994.
, Autoregulation by eicosanoids of human Kupffer cell secretory products. A study of interleukin-1, interleukin-6, tumor necrosis factor-alpha, transforming growth factor-beta, and nitric oxide, Ann. Surg, vol.219, pp.389-399, 1994.
, Control of nitric oxide production by endogenous TGF-beta1 and systemic nitric oxide in retinal pigment epithelial cells and peritoneal macrophages, J. Leukoc. Biol, vol.60, pp.261-270, 1996.
, Differentiation-dependent effects of IL-1 and TGF-beta on human articular chondrocyte proliferation are related to inducible nitric oxide synthase expression, J. Immunol. Baltim. Md, vol.154, pp.4018-4026, 1950.
, Further characterization and comparison of inducible nitric oxide synthase in mouse, rat, and human hepatocytes, Hepatol. Baltim. Md, vol.21, pp.1552-1560, 1995.
, IL-10 synergizes with IL-4 and transforming growth factor-beta to inhibit macrophage cytotoxic activity, J. Immunol. Baltim. Md, vol.148, pp.3578-3582, 1950.
, Inhibition of cytokine-induced nitric oxide production by transforming growth factor-beta 1 in human smooth muscle cells, J. Physiol, vol.454, pp.451-465, 1992.
, Mechanisms of suppression of macrophage nitric oxide release by transforming growth factor beta, J. Exp. Med, vol.178, pp.605-613, 1993.
, Modulation of human endothelial cell tetrahydrobiopterin synthesis by activating and deactivating cytokines: new perspectives on endothelium-derived relaxing factor, Biochem. Biophys. Res. Commun, vol.196, pp.1343-1348, 1993.
, Regulation of inducible nitric oxide synthase mRNA levels by differentiation and cytokines in human keratinocytes, Biochem. Biophys. Res. Commun, vol.220, pp.618-622, 1996.
, Regulation of inducible nitric oxide synthase mRNA levels by LPS, INF-gamma, TGF-beta, and IL-10 in murine macrophage cell lines and rat peritoneal macrophages, Biochem. Biophys. Res. Commun, vol.200, pp.126-134, 1994.
, Suppression of Interleukin-1?-induced Nitric-oxide Synthase Promoter/Enhancer Activity by Transforming Growth Factor-?1 in Vascular Smooth Muscle Cells EVIDENCE FOR MECHANISMS OTHER THAN NF-?B, J. Biol. Chem, vol.271, pp.13776-13780, 1996.
, The lethal effects of cytokine-induced nitric oxide on cardiac myocytes are blocked by nitric oxide synthase antagonism or transforming growth factor beta, J. Clin. Invest, vol.95, pp.677-685, 1995.
, Transforming growth factor beta 1 and gamma interferon provide opposing signals to lipopolysaccharide-activated mouse macrophages, Infect. Immun, vol.62, pp.3625-3632, 1994.
, Tissue expression of inducible nitric oxide synthase is closely associated with resistance to Leishmania major, J. Exp. Med, vol.180, pp.783-793, 1994.
, Targeted disruption of the mouse transforming growth factor-beta 1 gene results in multifocal inflammatory disease, Nature, vol.359, pp.693-699, 1992.
, Transforming growth factor beta 1 null mutation in mice causes excessive inflammatory response and early death, Proc. Natl. Acad. Sci. U. S. A, vol.90, pp.770-774, 1993.
, Spontaneously increased production of nitric oxide and aberrant expression of the inducible nitric oxide synthase in vivo in the transforming growth factor beta 1 null mouse, J. Exp. Med, vol.183, pp.2337-2342, 1996.
, Arrest of endotoxin-induced hypotension by transforming growth factor beta1, Proc. Natl. Acad. Sci. U. S. A, vol.93, pp.2054-2059, 1996.
, Transforming growth factor-beta in human cutaneous leishmaniasis, Am. J. Pathol, vol.147, pp.947-954, 1995.
, Megakaryocytes from patients with coronary atherosclerosis express the inducible nitric oxide synthase, Arterioscler. Thromb. Vasc. Biol, vol.15, pp.637-641, 1995.
, The serum concentration of active transforming growth factor-beta is severely depressed in advanced atherosclerosis, Nat. Med, vol.1, pp.74-79, 1995.
, Enhanced colonic nitric oxide generation and nitric oxide synthase activity in ulcerative colitis and Crohn's disease, Gut, vol.36, pp.718-723, 1995.
, Expression of transforming growth factors alpha and beta in colonic mucosa in inflammatory bowel disease, Gastroenterology, vol.110, pp.975-984, 1996.
, Immunohistochemical localization of transforming growth factor-beta receptors I and II in inflammatory bowel disease, J. Gastroenterol, vol.30, pp.76-77, 1995.
, Defective production of anti-inflammatory cytokine, TGF-beta by T cell lines of patients with active multiple sclerosis, J. Immunol. Baltim. Md, vol.152, pp.6003-6010, 1950.
, Induction of nitric oxide synthase in demyelinating regions of multiple sclerosis brains, Ann. Neurol, vol.36, pp.778-786, 1994.
, Nitric oxide synthase activity is elevated in brain microvessels in Alzheimer's disease, Biochem. Biophys. Res. Commun, vol.205, pp.659-665, 1994.
, Inducible nitric oxide synthase in tangle-bearing neurons of patients with Alzheimer's disease, J. Exp. Med, vol.184, pp.1425-1433, 1996.
, Altered expression of transforming growth factor-beta in Alzheimer's disease, Neurology, vol.45, pp.1561-1569, 1995.
, Transforming growth factor-beta stimulates arginase activity in macrophages. Implications for the regulation of macrophage cytotoxicity, J. Immunol. Baltim. Md, vol.155, pp.2077-2084, 1950.
, TGF beta 1 inhibits NF-kappa B/Rel activity inducing apoptosis of B cells: transcriptional activation of I kappa B alpha, Immunity, vol.5, pp.31-40, 1996.
, TGF-beta1 suppresses IFN-gamma-induced NO production in macrophages by suppressing STAT1 activation and accelerating iNOS protein degradation, Genes Cells Devoted Mol. Cell. Mech, vol.11, pp.871-882, 2006.
, TGF-beta1 enhances degradation of IFN-gamma-induced iNOS protein via proteasomes in RAW 264.7 cells, Nitric Oxide Biol. Chem, vol.13, pp.78-87, 2005.
, Smad2 and Smad3 are redundantly essential for the suppression of iNOS synthesis in macrophages by regulating IRF3 and STAT1 pathways, Int. Immunol, vol.24, pp.253-265, 2012.
, Negative regulation of inducible nitric-oxide synthase expression mediated through transforming growth factor-beta-dependent modulation of transcription factor TCF11, J. Biol. Chem, vol.282, pp.36837-36844, 2007.
, T antigen is bound to a host protein in SV40-transformed cells, Nature, vol.278, pp.261-263, 1979.
, Characterization of a 54K dalton cellular SV40 tumor antigen present in SV40-transformed cells and uninfected embryonal carcinoma cells, Cell, vol.17, pp.43-52, 1979.
, Detection of a transformation-related antigen in chemically induced sarcomas and other transformed cells of the mouse, Proc. Natl. Acad. Sci. U. S. A, vol.76, pp.2420-2424, 1979.
, The E6 oncoprotein encoded by human papillomavirus types 16 and 18 promotes the degradation of p53, Cell, vol.63, pp.1129-1136, 1990.
, Association of human papillomavirus types 16 and 18 E6 proteins with p53, Science, vol.248, pp.76-79, 1990.
, Participation of p53 cellular tumour antigen in transformation of normal embryonic cells, Nature, vol.312, pp.646-649, 1984.
, Cooperation between gene encoding p53 tumour antigen and ras in cellular transformation, Nature, vol.312, pp.649-651, 1984.
, Germ line p53 mutations in a familial syndrome of breast cancer, sarcomas, and other neoplasms, Science, vol.250, pp.1233-1238, 1990.
, Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours, Nature, vol.356, pp.215-221, 1992.
, TP53 mutations in human cancers: origins, consequences, and clinical use, Cold Spring Harb. Perspect. Biol, vol.2, p.1008, 2010.
, Aberrant expression of the p53 oncoprotein is a common feature of a wide spectrum of human malignancies, Oncogene, vol.6, pp.1699-1703, 1991.
, p53 Family and Cellular Stress Responses in Cancer, Front. Oncol, vol.4, p.285, 2014.
, Cancer. p53, guardian of the genome, Nature, vol.358, pp.15-16, 1992.
URL : https://hal.archives-ouvertes.fr/hal-00868358
, p53 Research: the past thirty years and the next thirty years, Cold Spring Harb. Perspect. Biol, vol.2, p.893, 2010.
, p53 mutations in human cancers, Science, vol.253, pp.49-53, 1991.
, Mutational landscape and significance across 12 major cancer types, Nature, vol.502, pp.333-339, 2013.
, Monoallelically expressed gene related to p53 at 1p36, a region frequently deleted in neuroblastoma and other human cancers, Cell, vol.90, pp.809-819, 1997.
, p63, a p53 homolog at 3q27-29, encodes multiple products with transactivating, death-inducing, and dominant-negative activities, Mol. Cell, vol.2, pp.305-316, 1998.
, Early diversification and complex evolutionary history of the p53 tumor suppressor gene family, Dev. Genes Evol, vol.217, pp.801-806, 2007.
, The p53 tumor suppressor-like protein nvp63 mediates selective germ cell death in the sea anemone Nematostella vectensis, PloS One, vol.2, p.782, 2007.
, The origins and evolution of the p53 family of genes, Cold Spring Harb. Perspect. Biol, vol.2, p.1198, 2010.
, p63 is a p53 homologue required for limb and epidermal morphogenesis, Nature, vol.398, pp.708-713, 1999.
, p63 is essential for regenerative proliferation in limb, craniofacial and epithelial development, Nature, vol.398, pp.714-718, 1999.
, p73-deficient mice have neurological, pheromonal and inflammatory defects but lack spontaneous tumours, Nature, vol.404, pp.99-103, 2000.
, p53 Isoforms: An Intracellular Microprocessor?, Genes Cancer, vol.2, pp.453-465, 2011.
, Generation of DeltaTAp73 proteins by translation from a putative internal ribosome entry site, Ann. N. Y. Acad. Sci, vol.1095, pp.315-324, 2007.
, One, two, three-p53, p63, p73 and chemosensitivity, Drug Resist. Updat. Rev. Comment. Antimicrob. Anticancer Chemother, vol.9, pp.288-306, 2006.
, p53/p63/p73 isoforms: an orchestra of isoforms to harmonise cell differentiation and response to stress, Cell Death Differ, vol.13, pp.962-972, 2006.
, Crystal structures of the DNA-binding domain tetramer of the p53 tumor suppressor family member p73 bound to different full-site response elements, J. Biol. Chem, vol.288, pp.4744-4754, 2013.
, Structure of p73 DNA-binding domain tetramer modulates p73 transactivation, Proc. Natl. Acad. Sci. U. S. A, vol.109, pp.6066-6071, 2012.
, Conformational stability and activity of p73 require a second helix in the tetramerization domain, Cell Death Differ, vol.16, pp.1582-1589, 2009.
, p73 function is inhibited by tumor-derived p53 mutants in mammalian cells, Mol. Cell. Biol, vol.19, pp.1438-1449, 1999.
, Dominant-negative p53 mutations selected in yeast hit cancer hot spots, Proc. Natl. Acad. Sci. U. S. A, vol.93, pp.4091-4095, 1996.
, Simple identification of dominant p53 mutants by a yeast functional assay, Carcinogenesis, vol.18, pp.2019-2021, 1997.
, Tumour p53 mutations exhibit promoter selective dominance over wild type p53, Oncogene, vol.21, pp.1641-1648, 2002.
, Gain of function of mutant p53 by coaggregation with multiple tumor suppressors, Nat. Chem. Biol, vol.7, pp.285-295, 2011.
, How many mutant p53 molecules are needed to inactivate a tetramer?, Mol. Cell. Biol, vol.24, pp.3536-3551, 2004.
DOI : 10.1128/mcb.24.8.3536-3551.2004
URL : https://mcb.asm.org/content/24/8/3536.full.pdf
, Prion-like aggregation of mutant p53 in cancer, Trends Biochem. Sci, vol.39, pp.260-267, 2014.
DOI : 10.1016/j.tibs.2014.04.001
, Human delta Np73 regulates a dominant negative feedback loop for TAp73 and p53, Cell Death Differ, vol.8, pp.1213-1223, 2001.
DOI : 10.1038/sj.cdd.4400962
URL : https://hal.archives-ouvertes.fr/hal-01606919
, Transactivation-deficient Delta TA-p73 inhibits p53 by direct competition for DNA binding: implications for tumorigenesis, J. Biol. Chem, vol.277, pp.14177-14185, 2002.
DOI : 10.1074/jbc.m200480200
URL : http://www.jbc.org/content/277/16/14177.full.pdf
, The dominant-negative interplay between p53, p63 and p73: A family affair, Oncotarget, vol.7, pp.69549-69564, 2016.
DOI : 10.18632/oncotarget.11774
URL : http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=download&path%5B%5D=11774&path%5B%5D=37238
, ?N-P63? and TA-P63? exhibit intrinsic differences in transactivation specificities that depend on distinct features of DNA target sites, Oncotarget, vol.5, pp.2116-2130, 2014.
, DeltaNp73beta is active in transactivation and growth suppression, Mol. Cell. Biol, vol.24, pp.487-501, 2004.
DOI : 10.1128/mcb.24.2.487-501.2004
URL : https://mcb.asm.org/content/mcb/24/2/487.full.pdf
, p63alpha and DeltaNp63alpha can induce cell cycle arrest and apoptosis and differentially regulate p53 target genes, Oncogene, vol.20, pp.3193-3205, 2001.
DOI : 10.1038/sj.onc.1204427
URL : https://www.nature.com/articles/1204427.pdf
, Regulation of HSF1-responsive gene expression by N-terminal truncated form of p73alpha, Biochem. Biophys. Res. Commun, vol.317, pp.865-872, 2004.
, Up-regulation of NFkappaB-responsive gene expression by DeltaNp73alpha in p53 null cells, Exp. Cell Res, vol.312, pp.1254-1264, 2006.
, Insights into p53 transcriptional function via genome-wide chromatin occupancy and gene expression analysis, Cell Death Differ, vol.19, 1992.
DOI : 10.1038/cdd.2012.89
URL : https://www.nature.com/articles/cdd201289.pdf
, A comprehensive and high-resolution genome-wide response of p53 to stress, Cell Rep, vol.8, pp.514-527, 2014.
, Definition of a consensus binding site for p53, Nat. Genet, vol.1, pp.45-49, 1992.
, A transcriptionally active DNAbinding site for human p53 protein complexes, Mol. Cell. Biol, vol.12, pp.2866-2871, 1992.
DOI : 10.1128/mcb.12.6.2866
URL : https://mcb.asm.org/content/12/6/2866.full.pdf
, Chromatin immunoprecipitation-based screen to identify functional genomic binding sites for sequence-specific transactivators, Mol. Cell. Biol, vol.25, pp.10148-10158, 2005.
DOI : 10.1128/mcb.25.22.10148-10158.2005
URL : https://mcb.asm.org/content/25/22/10148.full.pdf
, A global map of p53 transcription-factor binding sites in the human genome, Cell, vol.124, pp.207-219, 2006.
, An integrated map of p53binding sites and histone modification in the human ENCODE regions, Genomics, vol.89, pp.178-188, 2007.
, Diverse stresses dramatically alter genome-wide p53 binding and transactivation landscape in human cancer cells, Nucleic Acids Res, vol.41, pp.7286-7301, 2013.
DOI : 10.1093/nar/gkt504
URL : https://academic.oup.com/nar/article-pdf/41/15/7286/16948104/gkt504.pdf
, Sequence Variation in the Response Element Determines Binding by the Transcription Factor p73, Biochemistry (Mosc.), vol.54, pp.6961-6972, 2015.
, Recruitment of p300/CBP in p53-dependent signal pathways, Cell, vol.89, pp.1175-1184, 1997.
, Activation of p53 sequence-specific DNA binding by acetylation of the p53 C-terminal domain, Cell, vol.90, pp.595-606, 1997.
, Differential transactivation by the p53 transcription factor is highly dependent on p53 level and promoter target sequence, Mol. Cell. Biol, vol.22, pp.8612-8625, 2002.
, Comparative binding of p53 to its promoter and DNA recognition elements, J. Mol. Biol, vol.348, pp.589-596, 2005.
, ASPP proteins specifically stimulate the apoptotic function of p53, Mol. Cell, vol.8, pp.781-794, 2001.
, The common and distinct target genes of the p53 family transcription factors, Cell. Mol. Life Sci. CMLS, vol.61, pp.822-842, 2004.
, TAp63 induces senescence and suppresses tumorigenesis in vivo, Nat. Cell Biol, vol.11, pp.1451-1457, 2009.
, TAp73 knockout shows genomic instability with infertility and tumor suppressor functions, Genes Dev, vol.22, pp.2677-2691, 2008.
, TP63 and TP73 in cancer, an unresolved 'family' puzzle of complexity, redundancy and hierarchy, FEBS Lett, vol.588, pp.2590-2599, 2014.
, Identification of direct p73 target genes combining DNA microarray and chromatin immunoprecipitation analyses, J. Biol. Chem, vol.277, pp.43359-43368, 2002.
, M. deltaNp73 facilitates cell immortalization and cooperates with oncogenic Ras in cellular transformation in vivo, Mol. Cell. Biol, vol.23, pp.5540-5555, 2003.
, Tumor predisposition in mice mutant for p63 and p73: evidence for broader tumor suppressor functions for the p53 family, Cancer Cell, vol.7, pp.363-373, 2005.
, TAp73 regulates the spindle assembly checkpoint by modulating BubR1 activity, Proc. Natl. Acad. Sci. U. S. A, vol.106, pp.797-802, 2009.
, p73 is regulated by phosphorylation at the G2/M transition, J. Biol. Chem, vol.278, pp.49196-49202, 2003.
, M. p73 suppresses polyploidy and aneuploidy in the absence of functional p53, Mol. Cell, vol.27, pp.647-659, 2007.
, TAp73 is required for spermatogenesis and the maintenance of male fertility, Proc. Natl. Acad. Sci. U. S. A, vol.111, pp.1843-1848, 2014.
, TAp73 is essential for germ cell adhesion and maturation in testis, J. Cell Biol, vol.204, pp.1173-1190, 2014.
, p73 Induces apoptosis via PUMA transactivation and Bax mitochondrial translocation, J. Biol. Chem, vol.279, pp.8076-8083, 2004.
, DNp73 a matter of cancer: mechanisms and clinical implications, Biochim. Biophys. Acta, vol.1785, pp.207-216, 2008.
, Possible oncogenic potential of DeltaNp73: a newly identified isoform of human p73, Cancer Res, vol.62, pp.636-641, 2002.
, Transactivation-deficient DeltaTA-p73 acts as an oncogene, Cancer Res, vol.62, pp.3598-3602, 2002.
, Isoform-specific p73 knockout mice reveal a novel role for delta Np73 in the DNA damage response pathway, Genes Dev, vol.24, pp.549-560, 2010.
, Autonomous growth and hepatocarcinogenesis in transgenic mice expressing the p53 family inhibitor DNp73, Carcinogenesis, vol.29, pp.211-218, 2008.
, p63 mediates survival in squamous cell carcinoma by suppression of p73-dependent apoptosis, Cancer Cell, vol.9, pp.45-56, 2006.
, DeltaNp73, a dominant-negative inhibitor of wild-type p53 and TAp73, is upregulated in human tumors, J. Exp. Med, vol.196, pp.765-780, 2002.
, Inactivation of retinoblastoma (RB) tumor suppressor by oncogenic isoforms of the p53 family member p73, J. Biol. Chem, vol.278, pp.14230-14236, 2003.
, Mutational analysis of p73 and p53 in human cancer cell lines, Oncogene, vol.18, pp.3415-3421, 1999.
, Search for mutations and examination of allelic expression imbalance of the p73 gene at 1p36.33 in human lung cancers, Cancer Res, vol.58, pp.1380-1383, 1998.
, Patterns of p73 N-terminal isoform expression and p53 status have prognostic value in gynecological cancers, Int. J. Oncol, vol.29, pp.889-902, 2006.
, Transdominant DeltaTAp73 isoforms are frequently up-regulated in ovarian cancer. Evidence for their role as epigenetic p53 inhibitors in vivo, Cancer Res, vol.64, pp.2449-2460, 2004.
DOI : 10.1158/0008-5472.can-03-1060
, Aberrant expression of DeltaNp73 in benign and malignant tumours of the prostate: correlation with Gleason score, J. Clin. Pathol, vol.58, pp.1175-1179, 2005.
, Alterations of DeltaTA-p 73 splice transcripts during melanoma development and progression, Int. J. Cancer, vol.108, pp.162-166, 2004.
DOI : 10.1002/ijc.11552
URL : https://onlinelibrary.wiley.com/doi/pdf/10.1002/ijc.11552
, Expression of DeltaNp73 is a molecular marker for adverse outcome in neuroblastoma patients, Cell Death Differ, vol.9, pp.246-251, 2002.
, TAp73/Delta Np73 influences apoptotic response, chemosensitivity and prognosis in hepatocellular carcinoma, Cell Death Differ, vol.12, pp.1564-1577, 2005.
, p73 Expression in human normal and tumor tissues: loss of p73alpha expression is associated with tumor progression in bladder cancer, Clin. Cancer Res. Off. J. Am. Assoc. Cancer Res, vol.9, pp.5642-5651, 2003.
, High level expression of deltaNp63: a mechanism for the inactivation of p53 in undifferentiated nasopharyngeal carcinoma (NPC)?, Oncogene, vol.19, pp.3439-3444, 2000.
, Metabolic regulation by p53 family members, Cell Metab, vol.18, pp.617-633, 2013.
DOI : 10.1016/j.cmet.2013.06.019
URL : https://doi.org/10.1016/j.cmet.2013.06.019
, Cancer cell metabolism: one hallmark, many faces, Cancer Discov, vol.2, pp.881-898, 2012.
DOI : 10.1158/2159-8290.cd-12-0345
URL : http://cancerdiscovery.aacrjournals.org/content/2/10/881.full.pdf
, TAp73 enhances the pentose phosphate pathway and supports cell proliferation, Nat. Cell Biol, vol.15, pp.991-1000, 2013.
DOI : 10.1038/ncb2789
URL : http://europepmc.org/articles/pmc3733810?pdf=render
, Mdm2 promotes the rapid degradation of p53, Nature, vol.387, pp.296-299, 1997.
, The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation, Cell, vol.69, pp.1237-1245, 1992.
, Regulation of p73 activity by posttranslational modifications, Cell Death Dis, vol.3, p.285, 2012.
, p73 induction after DNA damage is regulated by checkpoint kinases Chk1 and Chk2, Genes Dev, vol.18, pp.3041-3054, 2004.
, Differential regulation of E2F1 apoptotic target genes in response to DNA damage, Nat. Cell Biol, vol.5, pp.552-558, 2003.
, Acetylation status of E2F-1 has an important role in the regulation of E2F-1-mediated transactivation of tumor suppressor p73, Biochem. Biophys. Res. Commun, vol.386, pp.207-211, 2009.
, Regulation of p73-mediated apoptosis by c-Jun Nterminal kinase, Biochem. J, vol.405, pp.617-623, 2007.
URL : https://hal.archives-ouvertes.fr/hal-00478707
, The tyrosine kinase c-Abl regulates p73 in apoptotic response to cisplatininduced DNA damage, Nature, vol.399, pp.806-809, 1999.
, p73 is regulated by tyrosine kinase c-Abl in the apoptotic response to DNA damage, Nature, vol.399, pp.814-817, 1999.
, Interaction of c-Abl and p73alpha and their collaboration to induce apoptosis, Nature, vol.399, pp.809-813, 1999.
, A positive role for c-Abl in Atm and Atr activation in DNA damage response, Cell Death Differ, vol.18, pp.5-15, 2011.
, Regulation of p73 by cAbl through the p38 MAP kinase pathway, Oncogene, vol.21, pp.974-979, 2002.
, DNA damage-dependent acetylation of p73 dictates the selective activation of apoptotic target genes, Mol. Cell, vol.9, pp.175-186, 2002.
, Cyclin-dependent kinases phosphorylate p73 at threonine 86 in a cell cycledependent manner and negatively regulate p73, J. Biol. Chem, vol.278, pp.27421-27431, 2003.
, Protein kinase C-dependent phosphorylation regulates the cell cycle-inhibitory function of the p73 carboxy terminus transactivation domain, Mol. Cell. Biol, vol.29, pp.1814-1825, 2009.
, p73beta is regulated by protein kinase Cdelta catalytic fragment generated in the apoptotic response to DNA damage, J. Biol. Chem, vol.277, pp.33758-33765, 2002.
, MDM2 and MDMX bind and stabilize the p53-related protein p73, Curr. Biol. CB, vol.9, pp.829-832, 1999.
, Inactivation of the p53-homologue p73 by the mdm2-oncoprotein, Oncogene, vol.18, pp.2101-2106, 1999.
, Mdm2 binds p73 alpha without targeting degradation, Oncogene, vol.18, pp.3923-3929, 1999.
, MDM2 suppresses p73 function without promoting p73 degradation, Mol. Cell. Biol, vol.19, pp.3257-3266, 1999.
, Mdm2-mediated NEDD8 modification of TAp73 regulates its transactivation function, J. Biol. Chem, vol.281, pp.34096-34103, 2006.
, The ubiquitin-protein ligase Itch regulates p73 stability, EMBO J, vol.24, pp.836-848, 2005.
, The Yes-associated protein 1 stabilizes p73 by preventing Itch-mediated ubiquitination of p73, Cell Death Differ, vol.14, pp.743-751, 2007.
, MDM2 mediates p73 ubiquitination: a new molecular mechanism for suppression of p73 function, Oncotarget, vol.6, pp.21479-21492, 2015.
, Mdm-2 and ubiquitin-independent p53 proteasomal degradation regulated by NQO1, Proc. Natl. Acad. Sci. U. S. A, vol.99, pp.13125-13130, 2002.
, Physical interaction of p73 with c-Myc and MM1, a c-Myc-binding protein, and modulation of the p73 function, J. Biol. Chem, vol.277, pp.15113-15123, 2002.
, Physical interaction with Yes-associated protein enhances p73 transcriptional activity, J. Biol. Chem, vol.276, pp.15164-15173, 2001.
, Akt phosphorylates the Yesassociated protein, YAP, to induce interaction with 14-3-3 and attenuation of p73-mediated apoptosis, Mol. Cell, vol.11, pp.11-23, 2003.
, Role for the p53 homologue p73 in E2F-1-induced apoptosis, Nature, vol.407, pp.645-648, 2000.
, The human p73 promoter: characterization and identification of functional E2F binding sites, vol.4, pp.195-203, 2002.
, The transcriptional repressor ZEB regulates p73 expression at the crossroad between proliferation and differentiation, Mol. Cell. Biol, vol.21, pp.8461-8470, 2001.
, Yin Yang 1 induces transcriptional activity of p73 through cooperation with E2F1, Biochem. Biophys. Res. Commun, vol.365, pp.75-81, 2008.
, DN-p73 is activated after DNA damage in a p53-dependent manner to regulate p53-induced cell cycle arrest, Oncogene, vol.21, pp.3796-3803, 2002.
, p53 induces the expression of its antagonist p73 Delta N, establishing an autoregulatory feedback loop, Oncogene, vol.21, pp.4715-4727, 2002.
, Autoinhibitory Regulation of p73 by ?Np73 To Modulate Cell Survival and Death through a p73-Specific Target Element within the ?Np73 Promoter, Mol. Cell. Biol, vol.22, pp.2575-2585, 2002.
, Autoinhibitory regulation of p73 by Delta Np73 to modulate cell survival and death through a p73-specific target element within the Delta Np73 promoter, Mol. Cell. Biol, vol.22, pp.2575-2585, 2002.
, p53 induces the expression of its antagonist p73 Delta N, establishing an autoregulatory feedback loop, Oncogene, vol.21, pp.4715-4727, 2002.
, Differential control of TAp73 and DeltaNp73 protein stability by the ring finger ubiquitin ligase PIR2, Proc. Natl. Acad. Sci. U. S. A, vol.107, pp.12877-12882, 2010.
, Jun regulates the stability and activity of the p53 homologue, p73, vol.279, pp.44713-44722, 2004.
, Yes-associated protein (YAP) is a critical mediator of c-Jun-dependent apoptosis, Cell Death Differ, vol.15, pp.217-219, 2008.
, TAp73 suppresses tumor angiogenesis through repression of proangiogenic cytokines and HIF-1? activity, Proc. Natl. Acad. Sci. U. S. A, vol.112, pp.220-225, 2015.
, p73 is required for endothelial cell differentiation, migration and the formation of vascular networks regulating VEGF and TGF? signaling, Cell Death Differ, vol.22, pp.1287-1299, 2015.
, p73: a Positive or Negative Regulator of Angiogenesis, or Both?, Mol. Cell. Biol, vol.36, pp.848-854, 2015.
, Novel role of p73 as a regulator of developmental angiogenesis: Implication for cancer therapy, Mol. Cell. Oncol, vol.3, p.1019973, 2016.
, p63 Is essential for the proliferative potential of stem cells in stratified epithelia, Cell, vol.129, pp.523-536, 2007.
, p63 deficiency activates a program of cellular senescence and leads to accelerated aging, Genes Dev, vol.19, 1986.
, TAp63 prevents premature aging by promoting adult stem cell maintenance, Cell Stem Cell, vol.5, pp.64-75, 2009.
, p63 is the molecular switch for initiation of an epithelial stratification program, Genes Dev, vol.18, pp.126-131, 2004.
, DeltaNp63 is essential for epidermal commitment of embryonic stem cells, PloS One, vol.3, p.3441, 2008.
, A dominant-negative form of p63 is required for epidermal proliferation in zebrafish, Dev. Cell, vol.2, pp.607-616, 2002.
, A. p63 regulates proliferation and differentiation of developmentally mature keratinocytes, Genes Dev, vol.20, pp.3185-3197, 2006.
URL : https://hal.archives-ouvertes.fr/hal-01450377
, A symphony of regulations centered on p63 to control development of ectoderm-derived structures, J. Biomed. Biotechnol, p.864904, 2011.
, Heterozygous germline mutations in the p53 homolog p63 are the cause of EEC syndrome, Cell, vol.99, pp.143-153, 1999.
, An anti-apoptotic role for the p53 family member, p73, during developmental neuron death, Science, vol.289, pp.304-306, 2000.
, Evidence that DeltaNp73 promotes neuronal survival by p53-dependent and p53independent mechanisms, J. Neurosci. Off. J. Soc. Neurosci, vol.24, pp.9174-9184, 2004.
, The invulnerability of adult neurons: a critical role for p73, J. Neurosci. Off. J. Soc. Neurosci, vol.24, pp.9638-9647, 2004.
, p73 is required for survival and maintenance of CNS neurons, J. Neurosci. Off. J. Soc. Neurosci, vol.22, pp.9800-9809, 2002.
, The aging brain, Annu. Rev. Pathol, vol.3, pp.41-66, 2008.
, p73 is critical for the persistence of memory, Cell Death Differ, vol.18, pp.381-382, 2011.
, TAp73 acts via the bHLH Hey2 to promote long-term maintenance of neural precursors, Curr. Biol. CB, vol.20, pp.2058-2065, 2010.
, Induction of neuronal differentiation by p73 in a neuroblastoma cell line, J. Biol. Chem, vol.275, pp.15226-15231, 2000.
, TAp73 isoforms antagonize Notch signalling in SH-SY5Y neuroblastomas and in primary neurones, J. Neurochem, vol.99, pp.989-999, 2006.
, Unifying the p73 knockout phenotypes: TAp73 orchestrates multiciliogenesis, Genes Dev, vol.30, pp.1253-1254, 2016.
, When cilia go bad: cilia defects and ciliopathies, Nat. Rev. Mol. Cell Biol, vol.8, pp.880-893, 2007.
, p73 Is Required for Multiciliogenesis and Regulates the Foxj1-Associated Gene Network, Cell Rep, vol.14, pp.2289-2300, 2016.
, TAp73 is a central transcriptional regulator of airway multiciliogenesis, Genes Dev, vol.30, pp.1300-1312, 2016.
, Emerging roles of p53 and other tumour-suppressor genes in immune regulation, Nat. Rev. Immunol, vol.16, pp.741-750, 2016.
, Integration of interferon-alpha/beta signalling to p53 responses in tumour suppression and antiviral defence, Nature, vol.424, pp.516-523, 2003.
, Transcriptional role of p53 in interferon-mediated antiviral immunity, J. Exp. Med, vol.205, pp.1929-1938, 2008.
, Dual Role of p53 in Innate Antiviral Immunity, vol.2, pp.298-313, 2010.
, p53 regulates Toll-like receptor 3 expression and function in human epithelial cell lines, Mol. Cell. Biol, vol.28, pp.6557-6567, 2008.
, Identification of the interferon regulatory factor 5 gene (IRF-5) as a direct target for p53, Oncogene, vol.21, pp.2914-2918, 2002.
, Transcriptional analysis of immune-related gene expression in p53-deficient mice with increased susceptibility to influenza A virus infection, BMC Med. Genomics, vol.8, p.52, 2015.
, Modulation of the ARF-p53 pathway by the small DNA tumor viruses, Cell Cycle Georget. Tex, vol.4, pp.449-452, 2005.
, Cross talk between PML and p53 during poliovirus infection: implications for antiviral defense, J. Virol, vol.80, pp.8582-8592, 2006.
URL : https://hal.archives-ouvertes.fr/inserm-00091615
, Interactions between the tumor suppressor p53 and immune responses, Curr. Opin. Oncol, vol.25, pp.85-92, 2013.
, Inflammation and p53, Genes Cancer, vol.2, pp.503-516, 2011.
, p53 is a suppressor of inflammatory response in mice, FASEB J. Off. Publ. Fed. Am. Soc. Exp. Biol, vol.19, pp.1030-1032, 2005.
, The Toll-like receptor gene family is integrated into human DNA damage and p53 networks, PLoS Genet, vol.7, p.1001360, 2011.
, The human TLR innate immune gene family is differentially influenced by DNA stress and p53 status in cancer cells, Cancer Res, vol.72, pp.3948-3957, 2012.
, p53 amplifies Toll-like receptor 5 response in human primary and cancer cells through interaction with multiple signal transduction pathways, Oncotarget, vol.6, pp.16963-16980, 2015.
, TLR-dependent T cell activation in autoimmunity, Nat. Rev. Immunol, vol.11, pp.807-822, 2011.
, Role of p53 in systemic autoimmune diseases, Crit. Rev. Immunol, vol.34, pp.509-516, 2014.
, Autoimmunity to the p53 protein is a feature of systemic lupus erythematosus (SLE) related to anti-DNA antibodies, J. Autoimmun, vol.17, pp.63-69, 2001.
, Regulation of joint destruction and inflammation by p53 in collagen-induced arthritis, Am. J. Pathol, vol.160, pp.123-130, 2002.
, Antibodies against p53 in sera from patients with systemic lupus erythematosus and other rheumatic diseases, Arthritis Rheum, vol.40, pp.980-982, 1997.
, p53 autoantibodies in patients with autoimmune diseases: a quantitative approach, Autoimmunity, vol.31, pp.229-235, 1999.
, p53 and NF-?B coregulate proinflammatory gene responses in human macrophages, Cancer Res, vol.74, pp.2182-2192, 2014.
, Tumor suppressor p53 inhibits autoimmune inflammation and macrophage function, Diabetes, vol.54, pp.1423-1428, 2005.
, Phagocytosis of apoptotic cells in homeostasis, Nat. Immunol, vol.16, pp.907-917, 2015.
, Clearance of apoptotic cells: implications in health and disease, J. Cell Biol, vol.189, pp.1059-1070, 2010.
, Do not let death do us part: 'find-me' signals in communication between dying cells and the phagocytes, Cell Death Differ, vol.23, pp.979-989, 2016.
, Control of signaling-mediated clearance of apoptotic cells by the tumor suppressor p53, Science, vol.349, p.1261669, 2015.
, Foxp3 expression in p53-dependent DNA damage responses, J. Biol. Chem, vol.285, pp.7995-8002, 2010.
, Beyond CTLA-4 and PD-1, the Generation Z of Negative Checkpoint Regulators, Front. Immunol, vol.6, p.418, 2015.
, Irradiation and anti-PD-L1 treatment synergistically promote antitumor immunity in mice, J. Clin. Invest, vol.124, pp.687-695, 2014.
, The blockade of immune checkpoints in cancer immunotherapy, Nat. Rev. Cancer, vol.12, pp.252-264, 2012.
, Immune checkpoint targeting in cancer therapy: toward combination strategies with curative potential, Cell, vol.161, pp.205-214, 2015.
, VISTA, a novel mouse Ig superfamily ligand that negatively regulates T cell responses, J. Exp. Med, vol.208, pp.577-592, 2011.
, Immunomodulatory Function of the Tumor Suppressor p53 in Host Immune Response and the Tumor Microenvironment, Int. J. Mol. Sci, vol.17, 2016.
, Macrophage activation and polarization, Front. Biosci. J. Virtual Libr, vol.13, pp.453-461, 2008.
, TAp73 is required for macrophage-mediated innate immunity and the resolution of inflammatory responses, Cell Death Differ, vol.20, pp.293-301, 2013.
, Nitric oxide-dependent activation of p53 suppresses bleomycin-induced apoptosis in the lung, J. Exp. Med, vol.192, pp.857-869, 2000.
, Pathways of apoptotic and non-apoptotic death in tumour cells, Nat. Rev. Cancer, vol.4, pp.592-603, 2004.
, Nitric oxide-induced genotoxicity, mitochondrial damage, and apoptosis in human lymphoblastoid cells expressing wild-type and mutant p53, Proc. Natl. Acad. Sci. U. S. A, vol.99, pp.10364-10369, 2002.
, Nitric oxide: NO apoptosis or turning it ON?, Cell Death Differ, vol.10, pp.864-869, 2003.
, p53 Activation by nitric oxide involves downregulation of Mdm2, J. Biol. Chem, vol.277, pp.15697-15702, 2002.
URL : https://hal.archives-ouvertes.fr/hal-02371516
, Nitric oxide-induced cellular stress and p53 activation in chronic inflammation, Proc. Natl. Acad. Sci. U. S. A, vol.100, pp.143-148, 2003.
, Nitric oxide induces phosphorylation of p53 and impairs nuclear export, Oncogene, vol.22, pp.2857-2868, 2003.
, Nitric oxide promotes p53 nuclear retention and sensitizes neuroblastoma cells to apoptosis by ionizing radiation, Cell Death Differ, vol.10, pp.468-476, 2003.
, Nitration of the tumor suppressor protein p53 at tyrosine 327 promotes p53 oligomerization and activation, Biochemistry (Mosc.), vol.49, pp.5331-5339, 2010.
, TAp73 induction by nitric oxide: regulation by checkpoint kinase 1 (CHK1) and protection against apoptosis, J. Biol. Chem, vol.286, pp.7873-7884, 2011.
, Nitric oxide-induced p53 accumulation and regulation of inducible nitric oxide synthase expression by wild-type p53, Proc. Natl. Acad. Sci. U. S. A, vol.93, pp.2442-2447, 1996.
, Up-regulation of inducible nitric oxide synthase expression in cancer-prone p53 knockout mice, Proc. Natl. Acad. Sci. U. S. A, vol.95, pp.8823-8828, 1998.
, Transcriptional repression by wild-type p53 utilizes histone deacetylases, mediated by interaction with mSin3a, Genes Dev, vol.13, pp.2490-2501, 1999.
, Repression of hsp90beta gene by p53 in UV irradiation-induced apoptosis of Jurkat cells, J. Biol. Chem, vol.279, pp.42545-42551, 2004.
, p53 induces differentiation of mouse embryonic stem cells by suppressing Nanog expression, Nat. Cell Biol, vol.7, pp.165-171, 2005.
, p53-Dependent transcriptional repression of cmyc is required for G1 cell cycle arrest, Mol. Cell. Biol, vol.25, pp.7423-7431, 2005.
, Slug antagonizes p53-mediated apoptosis of hematopoietic progenitors by repressing puma, Cell, vol.123, pp.641-653, 2005.
, p53-mediated repression of alpha-fetoprotein gene expression by specific DNA binding, Mol. Cell. Biol, vol.19, pp.1279-1288, 1999.
, DNA damage-induced downregulation of Cdc25C is mediated by p53 via two independent mechanisms: one involves direct binding to the cdc25C promoter, Mol. Cell, vol.16, pp.725-736, 2004.
, Depletion of TGF-? from fetal bovine serum, J. Immunol. Methods, vol.362, pp.195-198, 2010.
, Inhibition of gene markers of fibrosis with a novel inhibitor of transforming growth factor-beta type I receptor kinase in puromycin-induced nephritis, J. Pharmacol. Exp. Ther, vol.313, pp.943-951, 2005.
, T?RI Phosphorylation of Smad2 on Ser465 and Ser467 Is Required for Smad2Smad4 Complex Formation and Signaling, J. Biol. Chem, vol.272, pp.27678-27685, 1997.
, Macrophage cytostatic effect on Trypanosoma musculi involves an L-arginine-dependent mechanism, J. Immunol. Baltim. Md, vol.146, pp.4338-4343, 1950.
, Apoptosis of Trypanosoma musculi co-cultured with LPS activated macrophages: enhanced expression of nitric oxide synthase INFgamma and caspase, J. Submicrosc. Cytol. Pathol, vol.37, pp.99-107, 2005.
, ?Np73 Enhances Promoter Activity of TGF-? Induced Genes, PLoS ONE, vol.7, 2012.
, p53-mediated repression of nuclear factor-kappaB RelA via the transcriptional integrator p300, Cancer Res, vol.58, pp.4531-4536, 1998.
, TGF-beta suppresses IFN-gamma-STAT1-dependent gene transcription by enhancing STAT1-PIAS1 interactions in epithelia but not monocytes/macrophages, J. Immunol. Baltim. Md, vol.178, pp.4284-4295, 1950.
, The essential involvement of crosstalk between IFN-gamma and TGF-beta in the skin wound-healing process, J. Immunol. Baltim. Md, vol.172, pp.1848-1855, 1950.
, A mechanism of suppression of TGF-?/SMAD signaling by NF-?B/RelA, Genes Dev, vol.14, pp.187-197, 2000.
, TGF-? and NF-?B signal pathway cross-talk is mediated through TAK1 and SMAD7 in a subset of head and neck cancers, Oncogene, vol.32, pp.1549-1559, 2013.
, IKK(?) controls canonical TGF(ß)-SMAD signaling to regulate genes expressing SNAIL and SLUG during EMT in panc1 cells, J. Cell Sci, vol.123, pp.4231-4239, 2010.
, LPS/TLR4 Signaling Enhances TGF-? Response Through Downregulating BAMBI During Prostatic Hyperplasia, Sci. Rep, vol.6, p.27051, 2016.
, The peroxisome proliferator-activated receptor-gamma is a negative regulator of macrophage activation, Nature, vol.391, pp.79-82, 1998.
, Peroxisome proliferator-activated receptor gamma-dependent repression of the inducible nitric oxide synthase gene, Mol. Cell. Biol, vol.20, pp.4699-4707, 2000.
, Stimulation of nuclear receptor peroxisome proliferator-activated receptor-? limits NF-?B-dependent inflammation in mouse cystic fibrosis biliary epithelium, Hepatol. Baltim. Md, vol.62, pp.1551-1562, 2015.
, Smad3-mSin3A-HDAC1 Complex is Required for TGF-?1-Induced Transcriptional Inhibition of PPAR? in Mouse Cardiac Fibroblasts, Cell. Physiol. Biochem. Int. J. Exp. Cell. Physiol. Biochem. Pharmacol, vol.40, pp.908-920, 2016.
, Transforming growth factor ? suppresses peroxisome proliferator-activated receptor ? expression via both SMAD binding and novel TGF-? inhibitory elements, Biochem. J, vol.474, pp.1531-1546, 2017.
, Transforming growth factor beta-mediated transcriptional repression of c-myc is dependent on direct binding of Smad3 to a novel repressive Smad binding element, Mol. Cell. Biol, vol.24, pp.2546-2559, 2004.
, TGF-beta 1 inhibition of transin/stromelysin gene expression is mediated through a Fos binding sequence, Cell, vol.61, pp.267-278, 1990.
, Crosstalk between p53 and TGF-? Signalling, J. Signal Transduct, p.294097, 2012.
, Correlated abnormalities of transforming growth factor-beta 1 response and p53 expression in thyroid epithelial cell transformation, Mol. Cell. Endocrinol, vol.76, pp.13-21, 1991.
, Links between tumor suppressors: p53 is required for TGF-beta gene responses by cooperating with Smads, Cell, vol.113, pp.301-314, 2003.
, Redox control of p53 in the transcriptional regulation of TGF-?1 target genes through SMAD cooperativity, Cell. Signal, vol.26, pp.1427-1436, 2014.
, TGF-? induces p53/Smads complex formation in the PAI-1 promoter to activate transcription, Sci. Rep, vol.6, p.35483, 2016.
, The NOX Family of ROS-Generating NADPH Oxidases: Physiology and Pathophysiology, Physiol. Rev, vol.87, pp.245-313, 2007.
, Wild-type and mutant p53 differentially regulate NADPH oxidase 4 in TGF-?-mediated migration of human lung and breast epithelial cells, Br. J. Cancer, vol.110, pp.2569-2582, 2014.
, Histone modifications affect differential regulation of TGF?-induced NADPH oxidase 4 (NOX4) by wild-type and mutant p53, Oncotarget, vol.8, pp.44379-44397, 2017.
, Chromatin-bound p53 anchors activated Smads and the mSin3A corepressor to confer transforming-growth-factor-betamediated transcription repression, Mol. Cell. Biol, vol.28, 1988.
, A Mutant-p53/Smad complex opposes p63 to empower TGFbeta-induced metastasis, Cell, vol.137, pp.87-98, 2009.
, Mutant p53 promotes tumor cell malignancy by both positive and negative regulation of the transforming growth factor ? (TGF-?) pathway, J. Biol. Chem, vol.290, pp.11729-11740, 2015.
, Transforming growth factor-beta 1 inhibition of macrophage activation is mediated via Smad3, J. Biol. Chem, vol.275, pp.36653-36658, 2000.
, TAp73 loss favors Smad-independent TGF-? signaling that drives EMT in pancreatic ductal adenocarcinoma, Cell Death Differ, vol.23, pp.1358-1370, 2016.
URL : https://hal.archives-ouvertes.fr/hal-01796189
, Dynamics of TGF-?/Smad signaling, FEBS Lett, vol.586, pp.1921-1928, 2012.
, Crystal structure of SPSB2 in complex with a rational designed RGD-containing cyclic peptide inhibitor of SPSB2-iNOS interaction, Biochem. Biophys. Res. Commun, vol.489, pp.346-352, 2017.
, A potent cyclic peptide targeting SPSB2 protein as a potential anti-infective agent, J. Med. Chem, vol.57, pp.7006-7015, 2014.
, Design, Synthesis, and Characterization of Cyclic Peptidomimetics of the Inducible Nitric Oxide Synthase Binding Epitope That Disrupt the Protein-Protein Interaction Involving SPRY Domain-Containing Suppressor of Cytokine Signaling Box Protein (SPSB) 2 and Inducible Nitric Oxide Synthase, J. Med. Chem, vol.59, pp.5799-5809, 2016.
, Phosphorylated TP63 induces transcription of RPN13, leading to NOS2 protein degradation, J. Biol. Chem, vol.285, pp.41422-41431, 2010.
, TLR regulation of SPSB1 controls inducible nitric oxide synthase induction, J. Immunol. Baltim. Md, vol.187, pp.3798-3805, 1950.
, SPSB1, a Novel Negative Regulator of the Transforming Growth Factor-? Signaling Pathway Targeting the Type II Receptor, J. Biol. Chem, vol.290, pp.17894-17908, 2015.
, Analysis of the human tissue-specific expression by genome-wide integration of transcriptomics and antibody-based proteomics, Mol. Cell. Proteomics MCP, vol.13, pp.397-406, 2014.
, The story so far: Molecular regulation of the heme oxygenase-1 gene in renal injury, Am. J. Physiol. Renal Physiol, vol.286, pp.425-441, 2004.
, Transcriptional regulation of the AP-1 and Nrf2 target gene sulfiredoxin, Mol. Cells, vol.27, pp.279-282, 2009.
, NF-kappaB and AP-1 are key signaling pathways in the modulation of NAD(P)H:quinone oxidoreductase 1 gene by mercury, lead, and copper, J. Biochem. Mol. Toxicol, vol.22, pp.274-283, 2008.
, Regulation of Toll-like receptor-mediated Sestrin2 induction by AP-1, Nrf2, and the ubiquitin-proteasome system in macrophages, Toxicol. Sci. Off. J. Soc. Toxicol, vol.144, pp.425-435, 2015.
, The dual role of iNOS in cancer, Redox Biol, vol.6, pp.334-343, 2015.
, Loss of p53 in stromal fibroblasts enhances tumor cell proliferation through nitricoxide-mediated cyclooxygenase 2 activation, Free Radic. Res, vol.49, pp.269-278, 2015.
, The Dual Roles of NRF2 in Cancer, Trends Mol. Med, vol.22, pp.578-593, 2016.
, Interaction of natural killer cells with Trypanosoma cruzi-infected fibroblasts, Clin. Exp. Immunol, vol.145, pp.357-364, 2006.
, Nitric oxide, an autocrine regulator of wound fibroblast synthetic function, J. Immunol. Baltim. Md, vol.158, pp.2375-2381, 1950.
, The role of iNOS in wound healing, Surgery, vol.130, pp.225-229, 2001.
, Impaired Healing of a Cutaneous Wound in an Inducible Nitric Oxide SynthaseKnockout Mouse, Dermatol. Res. Pract, vol.2017, p.2184040, 2017.
, Nitric oxide-releasing nanoparticles accelerate wound healing by promoting fibroblast migration and collagen deposition, Am. J. Pathol, vol.180, pp.1465-1473, 2012.
, Nitric oxide production in cells derived from the human joint, Br. J. Rheumatol, vol.35, pp.207-212, 1996.
, Production of nitric oxide in the synovial membrane of rheumatoid and osteoarthritis patients, J. Exp. Med, vol.184, pp.1519-1524, 1996.
, Immunolocalization of inducible nitric oxide synthase in synovium and cartilage in rheumatoid arthritis and osteoarthritis, Br. J. Rheumatol, vol.36, pp.651-655, 1997.
, Adiponectin inhibits lipopolysaccharide-induced adventitial fibroblast migration and transition to myofibroblasts via AdipoR1-AMPK-iNOS pathway, Mol. Endocrinol. Baltim. Md, vol.24, pp.218-228, 2010.
, Macrophages activate iNOS signaling in adventitial fibroblasts and contribute to adventitia fibrosis, Nitric Oxide Biol. Chem, vol.61, pp.20-28, 2016.
, Autoinhibitory Regulation of p73 by ?Np73 To Modulate Cell Survival and Death through a p73-Specific Target Element within the ?Np73 Promoter, Mol. Cell. Biol, vol.22, pp.2575-2585, 2002.
, Redox-fibrosis: Impact of TGF?1 on ROS generators, mediators and functional consequences, Redox Biol, vol.6, pp.344-352, 2015.
, Nox4 involvement in TGF-beta and SMAD3-driven induction of the epithelial-to-mesenchymal transition and migration of breast epithelial cells. Free Radic, Biol. Med, vol.53, pp.1489-1499, 2012.
, Transforming growth factor-beta and matrix metalloproteinases: functional interactions in tumor stroma-infiltrating myeloid cells, ScientificWorldJournal, p.521754, 2014.