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Processus régénératifs du cerveau moyen dorsal chez le poisson zèbre adulte

Abstract : Unlike mammals, the adult teleost brain exhibits widespread neurogenic activity and can regenerate after injury. The adult zebrafish has the capacity to regenerate neurons from constitutive or latent progenitors. During my PhD, I studied the neuronal regeneration in the zebrafish dorsal midbrain (optic tectum, OT). At adult stage, neuroepithelial-like progenitors at the OT periphery contribute to neuronal and glial lineages during homeostasis.I identified a putative enhancer of meis2a, which allowed me to trace the progeny of neuroepithelial-like progenitors. In a non-regenerative context I showed that enhancer-targeted progenitors were at the origin of the whole structure during development and of its continued neurogenesis during post-embryonic growth.Following lesion, OT displayed reactive neurogenesis, at larval and adult stages, nevertheless its topographical structure remained altered. In adults, I showed that both constitutive neuroepithelial-like progenitors and latent ependymoglial progenitors were activated in a regenerative context.
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Submitted on : Wednesday, January 2, 2019 - 1:08:39 AM
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  • HAL Id : tel-01968023, version 1


Aurélie Heuzé. Processus régénératifs du cerveau moyen dorsal chez le poisson zèbre adulte. Neurobiologie. Université Paris Saclay (COmUE), 2017. Français. ⟨NNT : 2017SACLS508⟩. ⟨tel-01968023⟩



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