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Décryptage du Polymorphisme de Compatibilité dans l’interaction entre Biomphalaria glabrata et Schistosoma mansoni : une approche intégrative

Abstract : Biomphalaria glabrata is tropical fresh water snail, living in Latin America. This planorbe is the intermediary host of Schistosoma mansoni, a trematode responsible for the intestinal Schistosomiasis, second worldwide human vector-borne disease after the malaria. In this context, a better comprehension of the parasite/snail interaction is necessary and appearsa promising research field. The understanding of immunological interaction between the host and the parasite and the molecular mechanisms used by the two partners appears like essential for the discovery of new targets and new strategies in order to develop means of struggle against the pathogen. The aim of this thesis is to better understand the immunological interactions between the B. glabrata snail and S. mansoni trematode. Different aspects of the interaction between the snail and the parasite have been explored, from molecular and cellular bases to the tripartite interaction between the snail immunity, its microbiota and the pathogen. In a first step we have been able to demonstrate a gradient of parasite infectivities and snail susceptibilities from different geographical origins. Moreover, the immunological interaction between B. glabrata and S. mansoni is supported by local adaptation, at the molecular level. We were also able to show than an opsonin, the BgTEP, plays a key role in the interaction between B. glabrata and its various pathogens. Finally, the existence of a true tripartite interaction between the snail immune response, its microbiota and its parasite could was demonstrated.
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Anaïs Portet. Décryptage du Polymorphisme de Compatibilité dans l’interaction entre Biomphalaria glabrata et Schistosoma mansoni : une approche intégrative. Sciences agricoles. Université de Perpignan, 2017. Français. ⟨NNT : 2017PERP0035⟩. ⟨tel-01968022⟩

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