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Effet de l'exsudation des additifs sur les propriétés d'usage d'un dispositif médical implantable (cathéter)

Abstract : Surface state is one of the most important parameter determining the biocompatibility of animplantable medical device, any change on the surface once in contact with body tissues canimpact the biological response (Cytotoxicity, inflammation, irritation, thrombosis …etc). During storage, the blooming of additives may occur on the surface of polymers and modify their properties. In this study, we use (Pellethane®) catheter-based polyurethane, because of its many applications in the field of medical devices, to evaluate the impact of additives blooming on the biocompatibility. The impact of sterilizing and oxidation treatments on blooming was studied. The study was realized on polyurethane used in the fabrication of catheters on which the blooming of antioxidant crystals has been previously observed. Sterilization by ionizing radiations (beta, gamma) was performed on this material and samples were submitted to different kinds of oxidation process (UV, H2O2 and macrophages action). Endothelial cells viability was studied. A preliminary haemocompatibility evaluation was performed through the measurement of whole blood hemolysis, as well as platelet adhesion in contact with the different PU samples. The study of the pro-inflammatory IL-alpha; and TNF-alpha; production by macrophages in contact with samplesis also reported.
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Micheal Nouman. Effet de l'exsudation des additifs sur les propriétés d'usage d'un dispositif médical implantable (cathéter). Biomatériaux. Université Paris Saclay (COmUE), 2017. Français. ⟨NNT : 2017SACLS056⟩. ⟨tel-01968015⟩

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