?-Synuclein and the progression of cancer, FASEB J, vol.21, pp.3419-3430, 2007. ,
, , 2003.
, Prospective identification of tumorigenic breast cancer cells, Proc. Natl. Acad. Sci, vol.100, pp.3983-3988
Development and Preclinical Application of an Immunocompetent Transplant Model of Basal Breast Cancer with Lung, Liver and Brain Metastases, PLoS ONE, vol.11, 2016. ,
Intensity-modulated radiotherapy for hepatocellular carcinoma: dosimetric and clinical results, Oncotarget, vol.8, pp.59965-59976, 2017. ,
s-SHIP promoter expression marks activated stem cells in developing mouse mammary tissue, Genes Dev, vol.24, pp.1882-1892, 2010. ,
dlk acts as a negative regulator of Notch1 activation through interactions with specific EGF-like repeats, Exp. Cell Res, vol.303, pp.343-359, 2005. ,
Basal-like breast carcinomas: clinical outcome and response to chemotherapy, J. Clin. Pathol, vol.59, pp.729-735, 2006. ,
Enrichment of Human Stem-Like Prostate Cells with s-SHIP Promoter Activity Uncovers a Role in Stemness for the Long Noncoding RNA H19, Stem Cells Dev, vol.24, pp.1252-1262, 2015. ,
UV Irradiation Triggers Ubiquitin-Dependent Degradation of p21WAF1 to Promote DNA Repair, Cell, vol.114, pp.599-610, 2003. ,
Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell, Nat. Med, vol.3, p.730, 1997. ,
Choosing a Mouse Model: Experimental Biology in Context-The Utility and Limitations of Mouse Models of Breast Cancer, Cold Spring Harb. Perspect. Biol, 2011. ,
s-SHIP expression identifies a subset of murine basal prostate cells as neonatal stem cells, Oncotarget, vol.7, pp.29228-29244, 2016. ,
Coordinate Expansion of Murine Hematopoietic and Mesenchymal Stem Cell, 2015. ,
The Human SHIP Gene Is Differentially Expressed in Cell Lineages of the Bone Marrow and Blood, Blood, vol.89, pp.1876-1885, 1997. ,
The synucleins, Genome Biol, vol.3, pp.3002-3003, 2002. ,
ALDH1 Is a Marker of Normal and Malignant Human Mammary Stem Cells and a Predictor of Poor Clinical Outcome, Cell Stem Cell, vol.1, pp.555-567, 2007. ,
URL : https://hal.archives-ouvertes.fr/hal-01431968
Neuronal protein synuclein ? predicts poor clinical outcome in breast cancer, Int. J. Cancer, vol.121, pp.1296-1305, 2007. ,
Breast cancer-specific gene 1 interacts with the mitotic checkpoint kinase BubR1, Oncogene, vol.22, pp.7593-7599, 2003. ,
Unregulated long non-coding RNA-AK058003 promotes the proliferation, invasion and metastasis of breast cancer by regulating the expression levels of the ?-synuclein gene, Exp. Ther. Med, vol.9, pp.1727-1732, 2015. ,
Long non-coding RNA AK058003, as a precursor of miR-15a, interacts with HuR to inhibit the expression of ?-synuclein in hepatocellular carcinoma cells, Oncotarget, vol.8, pp.9451-9465, 2016. ,
Identification of conserved gene expression features between murine mammary carcinoma models and human breast tumors, 2007. ,
, Genome Biol, vol.8, p.76
Comparative oncogenomics identifies breast tumors enriched in functional tumor-initiating cells, Proc. Natl. Acad. Sci, vol.109, pp.2778-2783, 2012. ,
Up-regulation of gammasynuclein contributes to cancer cell survival under endoplasmic reticulum stress, J. Pathol, vol.217, pp.507-515, 2009. ,
Identification of gamma-synuclein as a new PCBP1-interacting protein, Neurol. Res, vol.38, pp.1064-1078, 2016. ,
The Par3-like polarity protein Par3L is essential for mammary stem cell maintenance, Nat. Cell Biol, vol.16, pp.526-534, 2014. ,
Stimulation of Breast Cancer Invasion and Metastasis by Synuclein ?, Cancer Res, vol.59, pp.742-747, 1999. ,
Stimulation of Estrogen Receptor Signaling by ? Synuclein, Cancer Res, vol.63, pp.3899-3903, 2003. ,
Modulation of dendritic cell function by the radiation-mediated secretory protein ?-synuclein, Cell Death Discov, vol.1, 2015. ,
Multiple forms of an inositol polyphosphate 5-phosphatase form signaling complexes with Shc and Grb2, Curr. Biol, vol.6, pp.438-445, 1996. ,
, , 2006.
, Imprinted DLK1 is a putative tumor suppressor gene and inactivated by epimutation at the region upstream of GTL2 in human renal cell carcinoma, Hum. Mol. Genet, vol.15, pp.821-830
, Hypoxia-Regulated Delta-like 1, 2009.
, Homologue Enhances Cancer Cell Stemness and Tumorigenicity, Cancer Res, vol.69, pp.9271-9280
Neuregulin 3 and erbb signalling networks in embryonic mammary gland development, J. Mammary Gland Biol. Neoplasia, vol.18, pp.149-154, 2013. ,
Endogenous p21 WAF1/CIP1 status predicts the response of human tumor cells to wild-type p53 and p21 WAF1/CIP1 overexpression, Cancer Gene Ther, vol.10, p.7700588, 2003. ,
RadiationInduced Reprogramming of Breast Cancer Cells, STEM CELLS, vol.30, pp.833-844, 2012. ,
A cell initiating human acute myeloid leukaemia after transplantation into SCID mice, Nature, vol.367, p.645, 1994. ,
Human soluble delta-like 1 homolog exerts antitumor effects in vitro and in vivo, Biochem. Biophys. Res. Commun, vol.475, pp.209-215, 2016. ,
Evidence that transgenes encoding components of the Wnt signaling pathway preferentially induce mammary cancers from progenitor cells, Proc. Natl. Acad. Sci. U. S. A, vol.100, pp.15853-15858, 2003. ,
Synuclein-? suppression mediated by RNA interference inhibits the clonogenicity and invasiveness of MCF-7 cells, Oncol. Lett, vol.5, pp.1347-1352, 2013. ,
The transforming activity of Wnt effectors correlates with their ability to induce the accumulation of mammary progenitor cells, Proc. Natl. Acad. Sci, vol.101, pp.4158-4163, 2004. ,
, , 2010.
, Synuclein gamma predicts poor clinical outcome in colon cancer with normal levels of carcinoembryonic antigen, BMC Cancer, vol.10, p.359
Urine gamma-synuclein as a biomarker for the diagnosis of bladder cancer, Oncotarget, vol.7, pp.43432-43441, 2016. ,
Loss of Epigenetic Control of Synuclein-? Gene as a Molecular Indicator of Metastasis in a Wide Range of Human Cancers, Cancer Res, vol.65, pp.7635-7643, 2005. ,
Transcriptional suppression of synuclein ? (SNCG) expression in human breast cancer cells by the growth inhibitory cytokine oncostatin M, Breast Cancer Res. Treat, vol.62, pp.99-107, 2000. ,
, , 2004.
, Upregulation of heme oxygenase-1 and p21 confers resistance to apoptosis in human gastric cancer cells, Oncogene, vol.23, p.1207173
Gamma-synuclein binds to AKT and promotes cancer cell survival and proliferation, Tumor Biol, vol.37, pp.14999-15005, 2016. ,
Prostate and mammary adenocarcinoma in transgenic mice carrying a rat C3(1) simian virus 40 large tumor antigen fusion gene, Proc. Natl. Acad. Sci. U. S. A, vol.91, pp.11236-11240, 1994. ,
Cancer stem cells: The challenges ahead, Nat. Cell Biol, vol.15, pp.338-344, 2013. ,
HuR silencing elicits oxidative stress and DNA damage and sensitizes human triple-negative breast cancer cells to radiotherapy, Oncotarget, vol.7, pp.64820-64835, 2016. ,
Genetically Engineered Mice as Experimental Tools to Dissect the Critical Events in Breast Cancer, Adv. Cancer Res, vol.121, pp.331-382, 2014. ,
, , 2014.
, Synuclein ? Compromises Spindle Assembly Checkpoint and Renders Resistance to Antimicrotubule Drugs, Mol. Cancer Ther, vol.13, pp.699-713
Overexpression of synuclein-? predicts lack of benefit from radiotherapy for breast cancer patients, BMC Cancer, vol.16, 2016. ,
MicroRNA expressing profiles in A53T mutant alpha-synuclein transgenic mice and Parkinsonian, Oncotarget, vol.8, pp.15-28, 2016. ,
Comprehensive molecular portraits of human breast tumours, Nature, vol.490, p.61, 2012. ,
A collection of breast cancer cell lines for the study of functionally distinct cancer subtypes, Cancer Cell, vol.10, pp.515-527, 2006. ,
, , 2007.
, The EGF-like Protein dlk1 Inhibits Notch Signaling and Potentiates Adipogenesis of Mesenchymal Cells, J. Mol. Biol, vol.367, pp.1281-1293
Different expression levels of DLK1 inversely modulate the oncogenic potential of human MDA-MB-231 breast cancer cells through inhibition of NOTCH1 signaling, FASEB J, vol.31, pp.3484-3496, 2017. ,
The mammary cellular hierarchy and breast cancer, Cell. Mol. Life Sci, vol.71, pp.4301-4324, 2014. ,
?-Synuclein Promotes Cancer Cell Survival and Inhibits Stress-and Chemotherapy Drug-induced Apoptosis by Modulating MAPK Pathways, J. Biol. Chem, vol.277, pp.35050-35060, 2002. ,
, , 2010.
, Targeting Cancer Stem Cells through Notch Signaling. Clin. Cancer Res. Off. J. Am. Assoc. Cancer Res, vol.16, pp.3141-3152
Cancer stem cells: The root of tumor recurrence and metastases, Semin. Cancer Biol, vol.44, pp.10-24, 2017. ,
Transcriptomic classification of genetically engineered mouse models of breast cancer identifies human subtype counterparts, 2013. ,
, Genome Biol, vol.14, p.125
, , 2013.
, Molecular Characterization of Basal-Like and Non-Basal-Like Triple-Negative Breast Cancer, The Oncologist, vol.18, pp.123-133
Stem cells, cancer, and cancer stem cells, Nature, vol.414, pp.105-111, 2001. ,
Ror2 regulates branching, differentiation, and actin-cytoskeletal dynamics within the mammary epithelium, J Cell Biol, vol.208, pp.351-366, 2015. ,
The intron 5/6 promoter region of the ship1 gene regulates expression in stem/progenitor cells of the mouse embryo, Dev. Biol, vol.283, pp.503-521, 2005. ,
Alternative splicing of synuclein gamma in endometrial cancer: identification of a novel isoform, Oncotarget, vol.6, pp.22553-22563, 2015. ,
MUC1 overexpression results in mammary gland tumorigenesis and prolonged alveolar differentiation, Oncogene, vol.23, pp.5739-5747, 2004. ,
Generation of a functional mammary gland from a single stem cell, Nature, vol.439, pp.84-88, 2006. ,
Cancer Stem Cells Contribute to Cisplatin Resistance in Brca1/p53Mediated Mouse Mammary Tumors, Cancer Res, vol.68, pp.3243-3250, 2008. ,
Synuclein gamma protects HER2 and renders resistance to Hsp90 disruption, Mol. Oncol, vol.8, pp.1521-1531, 2014. ,
Phenotypic and functional characterisation of the luminal cell hierarchy of the mammary gland, Breast Cancer Res, vol.14, p.134, 2012. ,
The breast cancer susceptibility gene product (?-synuclein) alters cell behavior through it interaction with phospholipase C?, Cell. Signal, vol.28, pp.91-99, 2016. ,
Molecular evolution of breast cancer, J. Pathol, vol.205, pp.248-254, 2005. ,
, , 2007.
, Synuclein-? Targeting Peptide Inhibitor that Enhances Sensitivity of Breast Cancer Cells to Antimicrotubule Drugs, Cancer Res, vol.67, pp.626-633
CD24 staining of mouse mammary gland cells defines luminal epithelial, myoepithelial/basal and non-epithelial cells, Breast Cancer Res, vol.8, p.7, 2005. ,
Molecular heterogeneity of breast carcinomas and the cancer stem cell hypothesis, Nat. Rev. Cancer, vol.7, pp.791-799, 2007. ,
Purification and unique properties of mammary epithelial stem cells, Nature, vol.439, pp.993-997, 2006. ,
Synuclein-? (SNCG) expression in ovarian cancer is associated with high-risk clinicopathologic disease, J. Ovarian Res, vol.9, p.75, 2016. ,
Synucleins and Gene Expression: Ramblers in a Crowd or Cops Regulating Traffic?, Front. Mol. Neurosci, vol.10, 2017. ,
?-Synuclein: Cell-Type-Specific Promoter Activity and Binding to Transcription Factors, J. Mol. Neurosci, vol.35, pp.267-271, 2008. ,
, , 2003.
, Effect of ?-synuclein overexpression on matrix metalloproteinases in retinoblastoma Y79 cells, Arch. Biochem. Biophys, vol.410, pp.167-176
Isolation of hepatoblasts based on the expression of Dlk/Pref-1, J. Cell Sci, vol.116, pp.1775-1786, 2003. ,
p21WAF1/CIP1 Antisense Therapy Radiosensitizes Human Colon Cancer by Converting Growth Arrest to Apoptosis, Cancer Res, vol.60, pp.679-684, 2000. ,
Global cancer statistics, 2012. CA, Cancer J. Clin, vol.65, pp.87-108 ,
Embryonic and hematopoietic stem cells express a novel SH2containing inositol 5?-phosphatase isoform that partners with the Grb2 adapter protein, Blood, vol.98, pp.2028-2038, 2001. ,
The Mammary Progenitor Marker CD61/?3 Integrin Identifies Cancer Stem Cells in Mouse Models of Mammary Tumorigenesis, Cancer Res, vol.68, pp.7711-7717, 2008. ,
Keeping abreast of the mammary epithelial hierarchy and breast tumorigenesis, Genes Dev, vol.23, pp.2563-2577, 2009. ,
Mammary stem cells and the differentiation hierarchy: current status and perspectives, Genes Dev, vol.28, pp.1143-1158, 2014. ,
Breast Cancer Subtypes and the Risk of Local and Regional Relapse, J. Clin. Oncol, vol.28, pp.1684-1691, 2010. ,
Hypoxia-Inducible lncRNA-AK058003 Promotes Gastric Cancer Metastasis by Targeting ?-Synuclein, Neoplasia, vol.16, pp.1094-1106, 2014. ,
p21Waf1/Cip1 as a therapeutic target in breast and other cancers, Cancer Cell, vol.4, pp.425-429, 2003. ,
Stage-specific Expression of Breast Cancer-specific Gene ?-Synuclein, Cancer Epidemiol. Prev. Biomark, vol.12, pp.920-925, 2003. ,
Expression of neuronal protein synuclein gamma gene as a novel marker for breast cancer prognosis, Breast Cancer Res. Treat, vol.101, pp.259-267, 2007. ,
Dlk-1, a cell surface antigen on foetal hepatic stem/progenitor cells, is expressed in hepatocellular, colon, pancreas and breast carcinomas at a high frequency, J. Biochem. (Tokyo), vol.148, pp.85-92, 2010. ,
?-Synuclein and the progression of cancer, FASEB J, vol.21, pp.3419-3430, 2007. ,
, , 2003.
, Prospective identification of tumorigenic breast cancer cells, Proc. Natl. Acad. Sci, vol.100, pp.3983-3988
Development and Preclinical Application of an Immunocompetent Transplant Model of Basal Breast Cancer with Lung, Liver and Brain Metastases, PLoS ONE, vol.11, 2016. ,
Intensity-modulated radiotherapy for hepatocellular carcinoma: dosimetric and clinical results, Oncotarget, vol.8, pp.59965-59976, 2017. ,
s-SHIP promoter expression marks activated stem cells in developing mouse mammary tissue, Genes Dev, vol.24, pp.1882-1892, 2010. ,
dlk acts as a negative regulator of Notch1 activation through interactions with specific EGF-like repeats, Exp. Cell Res, vol.303, pp.343-359, 2005. ,
Basal-like breast carcinomas: clinical outcome and response to chemotherapy, J. Clin. Pathol, vol.59, pp.729-735, 2006. ,
Enrichment of Human Stem-Like Prostate Cells with s-SHIP Promoter Activity Uncovers a Role in Stemness for the Long Noncoding RNA H19, Stem Cells Dev, vol.24, pp.1252-1262, 2015. ,
UV Irradiation Triggers Ubiquitin-Dependent Degradation of p21WAF1 to Promote DNA Repair, Cell, vol.114, pp.599-610, 2003. ,
Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell, Nat. Med, vol.3, p.730, 1997. ,
Choosing a Mouse Model: Experimental Biology in Context-The Utility and Limitations of Mouse Models of Breast Cancer, Cold Spring Harb. Perspect. Biol, 2011. ,
s-SHIP expression identifies a subset of murine basal prostate cells as neonatal stem cells, Oncotarget, vol.7, pp.29228-29244, 2016. ,
Coordinate Expansion of Murine Hematopoietic and Mesenchymal Stem Cell Compartments by SHIPi: Chemical Expansion of HSC and Their Niche, STEM CELLS, vol.33, pp.848-858, 2015. ,
Synucleins are expressed in the majority of breast and ovarian carcinomas and in preneoplastic lesions of the ovary, Cancer, vol.88, pp.2154-2163, 2000. ,
Multiple roles of the cell cycle inhibitor p21CDKN1A in the DNA damage response, Mutat. Res. Mutat. Res, vol.704, pp.12-20, 2010. ,
Triple Negative Breast Cancer Cell Lines: One Tool in the Search for Better Treatment of Triple Negative Breast Cancer, Breast Dis, vol.32, pp.35-48, 2010. ,
Neural protein gamma-synuclein interacting with androgen receptor promotes human prostate cancer progression, BMC Cancer, vol.12, p.593, 2012. ,
Isolation and Molecular Characterization of Cancer Stem Cells in MMTV-Wnt-1 Murine Breast Tumors, STEM CELLS, vol.26, pp.364-371, 2008. ,
Cancer Stem Cells-Perspectives on Current Status and Future Directions: AACR Workshop on Cancer Stem Cells, Cancer Res, vol.66, pp.9339-9344, 2006. ,
The synucleins: a family of proteins involved in synaptic function, plasticity, neurodegeneration and disease, Trends Neurosci, vol.21, pp.249-254 ,
SHIP deficiency enhances HSC proliferation and survival but compromises homing and repopulation, Blood, vol.107, pp.4338-4345, 2006. ,
Canonical and noncanonical Notch ligands, Curr. Top. Dev. Biol, vol.92, pp.73-129, 2010. ,
MCF7 Side Population Cells with Characteristics of Cancer Stem/Progenitor Cells Express the Tumor Antigen MUC1, Cancer Res, vol.68, pp.2419-2426, 2008. ,
An Antisense Oligodeoxynucleotide to p21Waf1/Cip1 Causes Apoptosis in Human Breast Cancer Cells1, Mol. Cancer Ther, vol.2, pp.773-782, 2003. ,
A Novel Oncogenic Role of Inositol Phosphatase SHIP2 in ER-Negative Breast Cancer Stem Cells: Involvement of JNK/Vimentin Activation, STEM CELLS, vol.32, pp.2048-2060, 2014. ,
, , 2012.
, Mol. Med, vol.18, p.1
The Human SHIP Gene Is Differentially Expressed in Cell Lineages of the Bone Marrow and Blood, Blood, vol.89, pp.1876-1885, 1997. ,
The synucleins, Genome Biol, vol.3, pp.3002-3003, 2002. ,
ALDH1 Is a Marker of Normal and Malignant Human Mammary Stem Cells and a Predictor of Poor Clinical Outcome, Cell Stem Cell, vol.1, pp.555-567, 2007. ,
URL : https://hal.archives-ouvertes.fr/hal-01431968
Neuronal protein synuclein ? predicts poor clinical outcome in breast cancer, Int. J. Cancer, vol.121, pp.1296-1305, 2007. ,
Breast cancer-specific gene 1 interacts with the mitotic checkpoint kinase BubR1, Oncogene, vol.22, pp.7593-7599, 2003. ,
Unregulated long non-coding RNA-AK058003 promotes the proliferation, invasion and metastasis of breast cancer by regulating the expression levels of the ?-synuclein gene, Exp. Ther. Med, vol.9, pp.1727-1732, 2015. ,
Long non-coding RNA AK058003, as a precursor of miR-15a, interacts with HuR to inhibit the expression of ?-synuclein in hepatocellular carcinoma cells, Oncotarget, vol.8, pp.9451-9465, 2016. ,
Identification of conserved gene expression features between murine mammary carcinoma models and human breast tumors, 2007. ,
, Genome Biol, vol.8, p.76
Comparative oncogenomics identifies breast tumors enriched in functional tumor-initiating cells, Proc. Natl. Acad. Sci, vol.109, pp.2778-2783, 2012. ,
Up-regulation of gammasynuclein contributes to cancer cell survival under endoplasmic reticulum stress, J. Pathol, vol.217, pp.507-515, 2009. ,
Identification of gamma-synuclein as a new PCBP1-interacting protein, Neurol. Res, vol.38, pp.1064-1078, 2016. ,
The Par3-like polarity protein Par3L is essential for mammary stem cell maintenance, Nat. Cell Biol, vol.16, pp.526-534, 2014. ,
Stimulation of Breast Cancer Invasion and Metastasis by Synuclein ?, Cancer Res, vol.59, pp.742-747, 1999. ,
Stimulation of Estrogen Receptor Signaling by ? Synuclein, Cancer Res, vol.63, pp.3899-3903, 2003. ,
Modulation of dendritic cell function by the radiation-mediated secretory protein ?-synuclein, Cell Death Discov, vol.1, 2015. ,
Multiple forms of an inositol polyphosphate 5-phosphatase form signaling complexes with Shc and Grb2, Curr. Biol, vol.6, pp.438-445, 1996. ,
, , 2006.
, Imprinted DLK1 is a putative tumor suppressor gene and inactivated by epimutation at the region upstream of GTL2 in human renal cell carcinoma, Hum. Mol. Genet, vol.15, pp.821-830
, Hypoxia-Regulated Delta-like 1, 2009.
DOI : 10.1158/0008-5472.can-09-1605
URL : http://cancerres.aacrjournals.org/content/69/24/9271.full.pdf
, Homologue Enhances Cancer Cell Stemness and Tumorigenicity, Cancer Res, vol.69, pp.9271-9280
Neuregulin 3 and erbb signalling networks in embryonic mammary gland development, J. Mammary Gland Biol. Neoplasia, vol.18, pp.149-154, 2013. ,
Endogenous p21 WAF1/CIP1 status predicts the response of human tumor cells to wild-type p53 and p21 WAF1/CIP1 overexpression, Cancer Gene Ther, vol.10, p.7700588, 2003. ,
RadiationInduced Reprogramming of Breast Cancer Cells, STEM CELLS, vol.30, pp.833-844, 2012. ,
A cell initiating human acute myeloid leukaemia after transplantation into SCID mice, Nature, vol.367, p.645, 1994. ,
Human soluble delta-like 1 homolog exerts antitumor effects in vitro and in vivo, Biochem. Biophys. Res. Commun, vol.475, pp.209-215, 2016. ,
Evidence that transgenes encoding components of the Wnt signaling pathway preferentially induce mammary cancers from progenitor cells, Proc. Natl. Acad. Sci. U. S. A, vol.100, pp.15853-15858, 2003. ,
Synuclein-? suppression mediated by RNA interference inhibits the clonogenicity and invasiveness of MCF-7 cells, Oncol. Lett, vol.5, pp.1347-1352, 2013. ,
The transforming activity of Wnt effectors correlates with their ability to induce the accumulation of mammary progenitor cells, Proc. Natl. Acad. Sci, vol.101, pp.4158-4163, 2004. ,
, , 2010.
, Synuclein gamma predicts poor clinical outcome in colon cancer with normal levels of carcinoembryonic antigen, BMC Cancer, vol.10, p.359
Urine gamma-synuclein as a biomarker for the diagnosis of bladder cancer, Oncotarget, vol.7, pp.43432-43441, 2016. ,
Loss of Epigenetic Control of Synuclein-? Gene as a Molecular Indicator of Metastasis in a Wide Range of Human Cancers, Cancer Res, vol.65, pp.7635-7643, 2005. ,
Transcriptional suppression of synuclein ? (SNCG) expression in human breast cancer cells by the growth inhibitory cytokine oncostatin M, Breast Cancer Res. Treat, vol.62, pp.99-107, 2000. ,
, , 2004.
, Upregulation of heme oxygenase-1 and p21 confers resistance to apoptosis in human gastric cancer cells, Oncogene, vol.23, p.1207173
Gamma-synuclein binds to AKT and promotes cancer cell survival and proliferation, Tumor Biol, vol.37, pp.14999-15005, 2016. ,
HuR silencing elicits oxidative stress and DNA damage and sensitizes human triple-negative breast cancer cells to radiotherapy, Oncotarget, vol.7, pp.64820-64835, 2016. ,
Genetically Engineered Mice as Experimental Tools to Dissect the Critical Events in Breast Cancer, Adv. Cancer Res, vol.121, pp.331-382, 2014. ,
, , 2014.
, Synuclein ? Compromises Spindle Assembly Checkpoint and Renders Resistance to Antimicrotubule Drugs, Mol. Cancer Ther, vol.13, pp.699-713
Overexpression of synuclein-? predicts lack of benefit from radiotherapy for breast cancer patients, BMC Cancer, vol.16, 2016. ,
MicroRNA expressing profiles in A53T mutant alpha-synuclein transgenic mice and Parkinsonian, Oncotarget, vol.8, pp.15-28, 2016. ,
Comprehensive molecular portraits of human breast tumours, Nature, vol.490, p.61, 2012. ,
A collection of breast cancer cell lines for the study of functionally distinct cancer subtypes, Cancer Cell, vol.10, pp.515-527, 2006. ,
, , 2007.
, The EGF-like Protein dlk1 Inhibits Notch Signaling and Potentiates Adipogenesis of Mesenchymal Cells, J. Mol. Biol, vol.367, pp.1281-1293
Different expression levels of DLK1 inversely modulate the oncogenic potential of human MDA-MB-231 breast cancer cells through inhibition of NOTCH1 signaling, FASEB J, vol.31, pp.3484-3496, 2017. ,
The mammary cellular hierarchy and breast cancer, Cell. Mol. Life Sci, vol.71, pp.4301-4324, 2014. ,
?-Synuclein Promotes Cancer Cell Survival and Inhibits Stress-and Chemotherapy Drug-induced Apoptosis by Modulating MAPK Pathways, J. Biol. Chem, vol.277, pp.35050-35060, 2002. ,
, , 2010.
, Targeting Cancer Stem Cells through Notch Signaling. Clin. Cancer Res. Off. J. Am. Assoc. Cancer Res, vol.16, pp.3141-3152
Cancer stem cells: The root of tumor recurrence and metastases, Semin. Cancer Biol, vol.44, pp.10-24, 2017. ,
Transcriptomic classification of genetically engineered mouse models of breast cancer identifies human subtype counterparts, 2013. ,
, Genome Biol, vol.14, p.125
, , 2013.
, Molecular Characterization of Basal-Like and Non-Basal-Like Triple-Negative Breast Cancer, The Oncologist, vol.18, pp.123-133
Stem cells, cancer, and cancer stem cells, Nature, vol.414, pp.105-111, 2001. ,
Ror2 regulates branching, differentiation, and actin-cytoskeletal dynamics within the mammary epithelium, J Cell Biol, vol.208, pp.351-366, 2015. ,
The intron 5/6 promoter region of the ship1 gene regulates expression in stem/progenitor cells of the mouse embryo, Dev. Biol, vol.283, pp.503-521, 2005. ,
Alternative splicing of synuclein gamma in endometrial cancer: identification of a novel isoform, Oncotarget, vol.6, pp.22553-22563, 2015. ,
MUC1 overexpression results in mammary gland tumorigenesis and prolonged alveolar differentiation, Oncogene, vol.23, pp.5739-5747, 2004. ,
Generation of a functional mammary gland from a single stem cell, Nature, vol.439, pp.84-88, 2006. ,
Cancer Stem Cells Contribute to Cisplatin Resistance in Brca1/p53Mediated Mouse Mammary Tumors, Cancer Res, vol.68, pp.3243-3250, 2008. ,
Synuclein gamma protects HER2 and renders resistance to Hsp90 disruption, Mol. Oncol, vol.8, pp.1521-1531, 2014. ,
Phenotypic and functional characterisation of the luminal cell hierarchy of the mammary gland, Breast Cancer Res, vol.14, p.134, 2012. ,
The breast cancer susceptibility gene product (?-synuclein) alters cell behavior through it interaction with phospholipase C?, Cell. Signal, vol.28, pp.91-99, 2016. ,
Molecular evolution of breast cancer, J. Pathol, vol.205, pp.248-254, 2005. ,
, , 2007.
, Synuclein-? Targeting Peptide Inhibitor that Enhances Sensitivity of Breast Cancer Cells to Antimicrotubule Drugs, Cancer Res, vol.67, pp.626-633
CD24 staining of mouse mammary gland cells defines luminal epithelial, myoepithelial/basal and non-epithelial cells, Breast Cancer Res, vol.8, p.7, 2005. ,
Molecular heterogeneity of breast carcinomas and the cancer stem cell hypothesis, Nat. Rev. Cancer, vol.7, pp.791-799, 2007. ,
Purification and unique properties of mammary epithelial stem cells, Nature, vol.439, pp.993-997, 2006. ,
Synuclein-? (SNCG) expression in ovarian cancer is associated with high-risk clinicopathologic disease, J. Ovarian Res, vol.9, p.75, 2016. ,
Synucleins and Gene Expression: Ramblers in a Crowd or Cops Regulating Traffic?, Front. Mol. Neurosci, vol.10, 2017. ,
?-Synuclein: Cell-Type-Specific Promoter Activity and Binding to Transcription Factors, J. Mol. Neurosci, vol.35, pp.267-271, 2008. ,
, , 2003.
, Effect of ?-synuclein overexpression on matrix metalloproteinases in retinoblastoma Y79 cells, Arch. Biochem. Biophys, vol.410, pp.167-176
Isolation of hepatoblasts based on the expression of Dlk/Pref-1, J. Cell Sci, vol.116, pp.1775-1786, 2003. ,
p21WAF1/CIP1 Antisense Therapy Radiosensitizes Human Colon Cancer by Converting Growth Arrest to Apoptosis, Cancer Res, vol.60, pp.679-684, 2000. ,
Global cancer statistics, 2012. CA, Cancer J. Clin, vol.65, pp.87-108 ,
DOI : 10.3322/caac.21262
URL : https://onlinelibrary.wiley.com/doi/pdf/10.3322/caac.21262
Embryonic and hematopoietic stem cells express a novel SH2containing inositol 5?-phosphatase isoform that partners with the Grb2 adapter protein, Blood, vol.98, pp.2028-2038, 2001. ,
The Mammary Progenitor Marker CD61/?3 Integrin Identifies Cancer Stem Cells in Mouse Models of Mammary Tumorigenesis, Cancer Res, vol.68, pp.7711-7717, 2008. ,
Keeping abreast of the mammary epithelial hierarchy and breast tumorigenesis, Genes Dev, vol.23, pp.2563-2577, 2009. ,
Mammary stem cells and the differentiation hierarchy: current status and perspectives, Genes Dev, vol.28, pp.1143-1158, 2014. ,
Breast Cancer Subtypes and the Risk of Local and Regional Relapse, J. Clin. Oncol, vol.28, pp.1684-1691, 2010. ,
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