, ?-CD103(clone M290), ?-granzyme-B (clone NGZB), ?-Ki67 (clone B56), ?-PD-1 (clone J43), ?-TIM-3-PE (R&D systems, clone 215008), ?-2B4 (Miltenyi, FITC, clone REA388; or Biolegend, PeCy7, clone m2B4(B6)458.1), ?-TIGIT (clone GIGD7), ?-CD160 (clone CNX46-3), ?-LAG-3 (clone C9B7W), ?-BTLA (clone 6F7), ?-NKG2A (clone 20D5), ?-CD5 (clone 53-7.3), ?MHC-class II (clone 2G9), ?-Sca-1 (clone D7), ?-CD34 (clone RAM34) and ?-EpCAM, ?-TCR?? (clone H57-597), ?-TCR?? (clone eBioGL3), ?-CD4 (clone GK1.5 or RM4-5), ?-CD8b (clone H35-17.2), ?-CD69 (clone H1.2F3)
Bergish Gladbach, Germany) or eBioscience (now ThermoFisher Scientific ,
, Fluorescent H-2Kb-restricted SIIC D FEKL or SIIK D FEKL dextramers were synthetized by Immudex
, Intracellular staining was performed using BD Cytofix/Cytoperm solutions (BD Biosciences, Cell viability was analysed using a Fixable Viability Dye, purchased from eBioscience
, CD3-AF700 (clone 17A2), ?-CD4-AF488 (clone RM4-5), ?-CD8b-AF647 (clone YST156.7.7), and ?-TCR??-PE (clone GLE) were purchased from Biolegend
, Chicken-?-Rabbit secondary mAb-AF488 were purchased from Life Technologies
, clone 7D6) was purchase from Life Technologies
, ?-CD45-FITC (clone HI30) and ?-CD8?-APC (clone 2ST8.5H7) were purchased from BD Biosciences
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DOI : 10.1038/nri3862
URL : http://europepmc.org/articles/pmc4889009?pdf=render
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