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Connectome structurel des réseaux neuronaux des patients d’épisode dépressif caractérisé étudié en IRM de tenseur de diffusion et de tractographie

Abstract : Major depressive disorder (MDD) is expanding on worldwide. Functional and volumetric imaging found abnormal activities and reductions in cerebral gray matter in MDD patients. However, the pattern of brain connections (structural connectome) of MDD patients in diffusion imaging remains unclear. The objective of this work is to study the structural connectome of MDD patients. For 3 years from 03/2014 to 03/2017, 56 MDD patients and 31 healthy controls (HC) were included in the study. All of these patients received the same venlafaxine depression treatment and were followed for 3 months. They received clinical evaluation and anatomical MRI and cerebral diffusion at baseline and at 3 months. HC are evaluated once at inclusion. At 3 months, 37 out of 56 patients completed all assessments. The old use of the antidepressant drugs (AD) and the previous episode of depression have been found to be related to the increased and decreased of cerebral anisotropy in depressed patients, respectively. No differences in cerebral anisotropy between patients and HC at baseline and at 3 months of treatment were detected. The response to AD is not related to patients’ cerebral anisotropy at baseline and at 3 months. The topography of the connections seems modified but not significant. This result showed for the first time 2 opposing affections of AD and depression on the cerebral structural connectome in long term.
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https://tel.archives-ouvertes.fr/tel-01961701
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Submitted on : Thursday, December 20, 2018 - 10:18:07 AM
Last modification on : Tuesday, September 29, 2020 - 4:37:44 AM
Long-term archiving on: : Friday, March 22, 2019 - 9:50:02 AM

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Minh Ngoc Thien Kim Tran Dong. Connectome structurel des réseaux neuronaux des patients d’épisode dépressif caractérisé étudié en IRM de tenseur de diffusion et de tractographie. Neurosciences [q-bio.NC]. Université Paris Saclay (COmUE), 2018. Français. ⟨NNT : 2018SACLS082⟩. ⟨tel-01961701⟩

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