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Alternative mechanisms in skin allergy processes : contribution of radical reactions from the molecule to the tissue

Abstract : Allergic contact dermatitis is a pathology affecting 15 to 20% of the Western population. Until now no treatment exists, the prevention is the eviction of allergens. In the past, tests concerning new molecules for the market were tested on animals until the prohibition in the 7th amendment of the European directive concerning the cosmetics industry. In this context it is essential to develop alternative methods to assess the allergenic potential of chemicals.This manuscript proposes to analyze the problem of the allergic contact dermatitis from the molecule to the tissue for allergens reacting through radical mechanisms:In chemico: study of the reactivity profile of allylic hydroperoxides toward amino acids by NMRIn situ: radical intermediates formation on reconstructed human epidermis from allylic hydroperoxides by EPR In cellulo: study of the oxidative stress from allylic hydroperoxides on dendritic cells trough the Keap1/Nrf2/ARE sensor pathway.
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Submitted on : Tuesday, December 4, 2018 - 10:41:48 AM
Last modification on : Wednesday, December 5, 2018 - 1:21:08 AM

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Salen Kuresepi. Alternative mechanisms in skin allergy processes : contribution of radical reactions from the molecule to the tissue. Organic chemistry. Université de Strasbourg, 2018. English. ⟨NNT : 2018STRAF010⟩. ⟨tel-01943778⟩

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