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Maladie d'Alzheimer et polyphénols : effet des tanins sur la phosphorylation de la protéine Tau

Abstract : Hyperphosphorylation of Tau protein, which leads to their abnormal aggregation into neurofibrillary tangles and to neuronal loss observed in patients with Alzheimer disease, is regulated by a disequilibrium between kinases and phosphatases activities. This post traductional modification affects several residues, in particular in the Proline Rich Region of Tau (PRR). But, NMR studies, realized in our laboratory, have shown that polyphenols are able to interact with peptide Tau models issued from the PRR and the affinity are in the same range that those described for the kinases. In this context, we have envisaged to synthetize several polyphenols and to develop a phosphorylation reaction of peptide models in order to study, by mass spectrometry, the ability of these compounds to protect Tau against kinase attack.
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https://tel.archives-ouvertes.fr/tel-01941709
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Submitted on : Sunday, December 2, 2018 - 1:04:49 AM
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Charlotte Fleau. Maladie d'Alzheimer et polyphénols : effet des tanins sur la phosphorylation de la protéine Tau. Chimie organique. Université de Bordeaux, 2017. Français. ⟨NNT : 2017BORD0776⟩. ⟨tel-01941709⟩

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