Deconstructing the molecular portraits of breast cancer, Mol. Oncol, vol.5, pp.5-23, 2011. ,
DOI : 10.1016/j.molonc.2010.11.003
URL : https://febs.onlinelibrary.wiley.com/doi/pdf/10.1016/j.molonc.2010.11.003
Molecular subclasses of breast cancer: How do we define them? The IMPAKT 2012 working group statement, Ann. Oncol, vol.23, pp.2997-3006, 2012. ,
The current state of breast cancer classification, Ann. Oncol, vol.23, 2012. ,
Membrane and Nuclear Estrogen Receptor Alpha Actions: From Tissue Specificity to Medical Implications, Physiol. Rev, vol.97, pp.1045-1087, 2017. ,
DOI : 10.1152/physrev.00024.2016
URL : https://hal.archives-ouvertes.fr/hal-01533249
Endocrine treatment in breast cancer: Cure, resistance and beyond, Cancer Treat. Rev, vol.50, pp.68-81, 2016. ,
DOI : 10.1016/j.ctrv.2016.08.008
Changes in Estrogen Receptor, Progesterone Receptor, and pS2 Expression in Tamoxifen-resistant Human Breast Cancer, Cancer Res, vol.55, pp.3331-3338, 1995. ,
, Endocrine-Related Cancer, vol.8, pp.191-195, 2001.
Luminal B breast cancer: patterns of recurrence and clinical outcome, Oncotarget, vol.7, pp.65024-65033, 2016. ,
DOI : 10.18632/oncotarget.11344
URL : http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=download&path%5B%5D=11344&path%5B%5D=35910
Oestrogen receptor negativity in breast cancer: a cause or consequence?, Biosci. Rep, vol.36, p.432, 2016. ,
DOI : 10.1042/bsr20160228
URL : http://www.bioscirep.org/content/36/6/e00432.full.pdf
Hypoxia reduces hormone responsiveness of human breast cancer cells, Jpn J Cancer Res, vol.92, pp.1093-1101, 2001. ,
DOI : 10.1111/j.1349-7006.2001.tb01064.x
Biology of hypoxia, Semin. Nucl. Med, vol.45, pp.101-109, 2015. ,
Detection and characterization of tumor hypoxia using pO2 histography, Antioxid Redox Signal, vol.9, pp.1221-1235, 2007. ,
DOI : 10.1089/ars.2007.1628
The role of hypoxia in cancer progression, angiogenesis, metastasis, and resistance to therapy, Hypoxia, p.83, 2015. ,
Reiee Hallaaks of Caaee : The Neet Geeeatio, Cell, vol.144, pp.646-674, 2011. ,
Hypoxia-Inducible Factors: Master Regulators of Cancer Progression, Trends in Cancer, vol.2, pp.758-770, 2016. ,
The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis, Nature, vol.399, pp.271-275, 1999. ,
Oxygen Sensing by Metazoans: The Central Role of the HIF Hydroxylase Pathway, Mol. Cell, vol.30, pp.393-402, 2008. ,
The hypoxia associated factor (HAF) switches cells from HIF-1? to HIF-2? dependent signaling promoting stem cell characteristics, aggressive tumor growth and invasion.pdf, Cancer Res, vol.71, pp.4015-4042, 2011. ,
Passing the baton: The HIF switch, Trends Biochem. Sci, vol.37, pp.364-372, 2012. ,
Cobalt chloride-induced estrogen receptor alpha down ,
The origin of breast tumor heterogeneity, Oncogene, vol.34, pp.5309-5316, 2015. ,
Molecular portraits of human breast tumours, Nature, vol.406, pp.747-752, 2000. ,
Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications, Proc. Natl. Acad. Sci. U. S. A, vol.98, pp.10869-10874, 2001. ,
Estrogens and their receptors in breast cancer progression: a dual role in cancer proliferation and invasion, Crit. Rev. Oncol. Hematol, vol.51, pp.55-67, 2004. ,
URL : https://hal.archives-ouvertes.fr/inserm-00144757
International Union of Pharmacology. LXIV. Estrogen receptors, Pharmacol. Rev, vol.58, pp.773-781, 2006. ,
Steroid hormone receptors in breast cancer management, Breast Cancer Res. Treat, vol.51, pp.227-238, 1998. ,
The use of tamoxifen and raloxifene for the prevention of breast cancer. Recent Results Cancer Res. Fortschritte Krebsforsch, Progres Dans Rech. Sur Cancer, vol.181, pp.113-119, 2009. ,
Seletie estogee-receptor modulators and antihormonal resistance in breast cancer, J. Clin. Oncol. Off. J. Am. Soc. Clin. Oncol, vol.25, pp.5815-5824, 2007. ,
Endocrine resistance in breast cancer-An overview and update, Mol. Cell. Endocrinol. 418 Pt, vol.3, pp.220-234, 2015. ,
Biological determinants of endocrine resistance in breast cancer, Nat. Rev. Cancer, vol.9, pp.631-643, 2009. ,
Oestrogen receptor negativity in breast cancer: a cause or consequence?, Biosci. Rep, vol.36, 2016. ,
Genome-wide analysis of estrogen receptor binding sites, Nat. Genet, vol.38, pp.1289-1297, 2006. ,
ChIP-Seq of ERalpha and RNA polymerase II defines genes differentially responding to ligands, EMBO J, vol.28, pp.1418-1428, 2009. ,
Differential oestrogen receptor binding is associated with clinical outcome in breast cancer, Nature, vol.481, pp.389-393, 2012. ,
Pioneer factors in hormone-dependent cancers, Nat. Rev. Cancer, vol.12, pp.381-385, 2012. ,
Basal-like and triple-negative breast cancers: a critical review with an emphasis on the implications for pathologists and oncologists, Mod. Pathol. Off. J. U. S. Can. Acad. Pathol. Inc, vol.24, pp.157-167, 2011. ,
Aberrant luminal progenitors as the candidate target population for basal tumor development in BRCA1 mutation carriers, Nat. Med, vol.15, pp.907-913, 2009. ,
BRCA1 basal-like breast cancers originate from luminal epithelial progenitors and not from basal stem cells, Cell Stem Cell, vol.7, pp.403-417, 2010. ,
ERRRR?heee aae the ppogeeitos? Hooe eeptos aad aaaa cell heterogeneity, J. Mammary Gland Biol. Neoplasia, vol.20, pp.63-73, 2015. ,
Loss of estrogen receptor in recurrent breast cancer is associated with poor response to endocrine therapy, J. Clin. Oncol. Off. J. Am. Soc. Clin. Oncol, vol.14, pp.2584-2589, 1996. ,
Actin dynamics control SRF activity by regulation of its coactivator MAL, Cell, vol.113, pp.329-342, 2003. ,
The myocardin family of transcriptional coactivators: versatile regulators of cell growth, migration, and myogenesis, Genes Dev, vol.20, pp.1545-1556, 2006. ,
Myocardin-related transcription factors and SRF are required for cytoskeletal dynamics and experimental metastasis, Nat. Cell Biol, vol.11, pp.257-268, 2009. ,
Genome-wide association study identifies 25 known breast cancer susceptibility loci as risk factors for triple-negative breast cancer, Carcinogenesis, vol.35, pp.1012-1019, 2014. ,
SAP domaindependent Mkl1 signaling stimulates proliferation and cell migration by induction of a distinct gene set indicative of poor prognosis in breast cancer patients, Mol. Cancer, vol.13, p.22, 2014. ,
Genome-wide association study identifies multiple loci associated with both mammographic density and breast cancer risk, Nat. Commun, vol.5, p.5303, 2014. ,
Activation of the MKL1/actin signaling pathway induces hormonal escape in estrogen-responsive breast cancer cell lines, Mol. Cell. Endocrinol, vol.390, pp.34-44, 2014. ,
URL : https://hal.archives-ouvertes.fr/hal-01061363
The actin/MKL1 signalling pathway influences cell growth and gene expression through large-scale chromatin reorganization and histone post-translational modifications, Biochem. J, vol.461, pp.257-268, 2014. ,
URL : https://hal.archives-ouvertes.fr/hal-01063933
Bioconductor: open software development for computational biology and bioinformatics, Genome Biol, vol.5, p.80, 2004. ,
limmaGUI: a graphical user interface for linear modeling of microarray data, Bioinforma. Oxf. Engl, vol.20, pp.3705-3706, 2004. ,
clusterProfiler: an R package for comparing biological themes among gene clusters, Omics J. Integr. Biol, vol.16, pp.284-287, 2012. ,
Dynamic estrogen receptor interactomes control estrogen-responsive trefoil Factor (TFF) locus cell-specific activities, Mol. Cell. Biol, vol.34, pp.2418-2436, 2014. ,
Changes in Gene Expression and Estrogen Receptor Cistrome in Mouse Liver Upon Acute E2 Treatment, Mol. Endocrinol. Baltim. Md, vol.30, pp.709-732, 2016. ,
URL : https://hal.archives-ouvertes.fr/hal-01357623
Ultrafast and memory-efficient alignment of short DNA sequences to the human genome, Genome Biol, vol.10, p.25, 2009. ,
The Sequence Alignment/Map format and SAMtools, Bioinforma. Oxf. Engl, vol.25, pp.2078-2079, 2009. ,
Identifying ChIP-seq enrichment using MACS, Nat. Protoc, vol.7, pp.1728-1740, 2012. ,
Cistrome: an integrative platform for transcriptional regulation studies, Genome Biol, vol.12, p.83, 2011. ,
NCBI GEO: archive for high-throughput functional genomic data, Nucleic Acids Res, vol.37, pp.885-890, 2009. ,
Molecular mechanisms of epithelial-mesenchymal transition, Nat. Rev. Mol. Cell Biol, vol.15, pp.178-196, 2014. ,
Linking epithelial-to-mesenchymal-transition and epigenetic modifications, Semin. Cancer Biol, vol.22, pp.404-410, 2012. ,
The epigenetics of epithelial-mesenchymal plasticity in cancer, Nat. Med, vol.19, pp.1438-1449, 2013. ,
Repeated observation of breast tumor subtypes in independent gene expression data sets, Proc. Natl. Acad. Sci. U. S. A, vol.100, pp.8418-8423, 2003. ,
FOXC1 is a potential prognostic biomarker with functional significance in basal-like breast cancer, Cancer Res, vol.70, pp.3870-3876, 2010. ,
Profiling of estrogen up-and down-regulated gene expression in human breast cancer cells: insights into gene networks and pathways underlying estrogenic control of proliferation and cell phenotype, Endocrinology, vol.144, pp.4562-4574, 2003. ,
Integrative analysis of deep sequencing data identifies estrogen receptor early response genes and links ATAD3B to poor survival in breast cancer, PLoS Comput. Biol, vol.9, p.1003100, 2013. ,
An oestrogen-receptor-alpha-bound human chromatin interactome, Nature, vol.462, pp.58-64, 2009. ,
GREAT improves functional interpretation of cis-regulatory regions, Nat. References ,
Epigenetic inheritance uncoupled from sequence-specific recruitment, Science, vol.348, p.1258699, 2015. ,
Loss of the Suv39h histone methyltransferases impairs mammalian heterochromatin and genome stability, Cell, vol.107, pp.323-337, 2001. ,
Embryonic development following somatic cell nuclear transfer impeded by persisting histone methylation, Cell, vol.159, pp.884-895, 2014. ,
Transient JMJD2B-mediated reduction of H3K9me3 levels improves reprogramming of embryonic stem cells into cloned embryos, Mol. Cell. Biol, vol.33, pp.974-983, 2013. ,
,
Suv39h-mediated histone H3 lysine 9 methylation directs DNA methylation to major satellite repeats at pericentric heterochromatin, Curr. Biol, vol.13, pp.1192-1200, 2003. ,
, G9a-mediated irreversible epigenetic inactivation of Oct-3/4 during early embryogenesis, vol.8, pp.188-194, 2006.
Distinct epigenomic landscapes of pluripotent and lineage-committed human cells, Cell Stem Cell, vol.6, pp.479-491, 2010. ,
Chromatin in pluripotent embryonic stem cells and differentiation, Nat. Rev. Mol. Cell. Biol, vol.7, pp.540-546, 2006. ,
The epigenomics of embryonic stem cell differentiation, Int. J. Biol. Sci, vol.9, pp.1134-1144, 2013. ,
Global transcription in pluripotent embryonic stem cells, Cell Stem Cell, vol.2, pp.437-447, 2008. ,
Jmjd1a and Jmjd2c histone H3 Lys 9 demethylases regulate self-renewal in embryonic stem cells, Genes Dev, vol.21, pp.2545-2557, 2007. ,
Partitioning and plasticity of repressive histone methylation states in mammalian chromatin, Mol. Cell, vol.12, pp.1577-1189, 2003. ,
Genome-scale epigenetic reprogramming during epithelial-to-mesenchymal transition, Nat. Struct. Mol. Biol, vol.18, pp.867-874, 2011. ,
The actin/MKL1 signalling pathway influences cell growth and gene expression through large-scale chromatin reorganization and histone post-translational modifications, Biochem. J, vol.461, pp.257-268, 2014. ,
URL : https://hal.archives-ouvertes.fr/hal-01063933
The disappearing Barr body in breast and ovarian cancers, Nat. Rev. Cancer, vol.7, pp.628-633, 2007. ,
Cancer-associated alteration of pericentromeric heterochromatin may contribute to chromosome instability, Oncogene, vol.31, pp.3244-3253, 2012. ,
Oncogene-induced senescence as an initial barrier in lymphoma development, Nature, vol.436, pp.660-665, 2005. ,
Prolyl isomerase Pin1 negatively regulates the stability of SUV39H1 to promote tumorigenesis in breast cancer, FASEB J, vol.27, pp.4606-4618, 2013. ,
Genomic amplification and oncogenic properties of the GASC1 histone demethylase gene in breast cancer, Oncogene, vol.28, pp.4491-4500, 2009. ,
Hypoxiainducible histone lysine demethylases: Impact on the aging process and age-related diseases, Aging Dis, vol.7, pp.180-200, 2016. ,
Hypoxia drives transient site-specific copy gain and drugresistant gene expression, Genes Dev, vol.29, pp.1018-1031, 2015. ,
DOI : 10.1101/gad.259796.115
URL : http://genesdev.cshlp.org/content/29/10/1018.full.pdf
Envisioning metastasis as a transdifferentiation phenomenon clarifies discordant results on cancer, Breast Dis, vol.36, pp.47-59, 2016. ,
URL : https://hal.archives-ouvertes.fr/hal-01367146
Formation of facultative heterochromatin in the absence of HP1, EMBO J, vol.22, pp.5540-5550, 2003. ,
Genome-wide chromatin state transitions associated with developmental and environmental cues, Cell, vol.152, pp.642-654, 2013. ,
DOI : 10.1016/j.cell.2012.12.033
URL : https://doi.org/10.1016/j.cell.2012.12.033
Recruitment and biological consequences of histone modification of H3K27me3 and H3K9me3, ILAR J, vol.53, pp.232-239, 2012. ,
Dynamics and memory of heterochromatin in living cells, Cell, vol.149, pp.1447-1460, 2012. ,
Pericentric heterochromatin: dynamic organization during early development in mammals, Differentiation, vol.76, pp.15-23, 2008. ,
DOI : 10.1111/j.1432-0436.2007.00220.x
Nuclear architecture of rod photoreceptor cells adapts to vision in mammalian evolution, Cell, vol.137, pp.356-368, 2009. ,
Chromatin dynamics, Annu. Rev. Biophys, vol.39, pp.471-489, 2010. ,
Suv39h-dependent H3K9me3 marks intact retrotransposons and silences LINE elements in mouse embryonic stem cells, Mol. Cell, vol.55, pp.277-290, 2014. ,
DOI : 10.1016/j.molcel.2014.05.029
URL : https://doi.org/10.1016/j.molcel.2014.05.029
Preferential association of irreversibly silenced E2F-target genes with pericentromeric heterochromatin in differentiated muscle cells, Epigenetics, vol.5, pp.704-709, 2010. ,
Dynamic and flexible H3K9me3 bridging via HP1? dimerization establishes a plastic state of condensed chromatin, Nat. Commun, vol.7, p.11310, 2016. ,
DOI : 10.1038/ncomms11310
URL : http://www.nature.com/articles/ncomms11310.pdf
Heterochromatin: proteins in flux lead to stable repression, Curr. Biol, vol.13, pp.317-326, 2003. ,
DOI : 10.1016/s0960-9822(03)00236-7
URL : https://doi.org/10.1016/s0960-9822(03)00236-7
Epigenetic memories: structural marks or active circuits?, Cell. Mol. Life Sci, vol.69, pp.2189-2203, 2012. ,
The emerging field of dynamic lysine methylation of non-histone proteins, Curr Opin Genet Dev, vol.18, pp.152-158, 2008. ,
Maintenance of stable heterochromatin domains by dynamic HP1 binding, Science, vol.299, pp.721-725, 2003. ,
DOI : 10.1126/science.1078572
Theoretical analysis of epigenetic cell memory by nucleosome modification, Cell, vol.129, pp.813-822, 2007. ,
DOI : 10.1016/j.cell.2007.02.053
URL : https://doi.org/10.1016/j.cell.2007.02.053
Epigenetic inheritance during the cell cycle, Nat. Rev. Mol. Cell. Biol, vol.10, pp.192-206, 2009. ,
DOI : 10.1038/nrm2640
Mechanisms for the inheritance of chromatin states, Cell, vol.146, pp.510-518, 2011. ,
Epigenetic inheritance: uncontested?, Cell Res, vol.21, pp.435-441, 2011. ,
DOI : 10.1038/cr.2011.26
URL : https://www.nature.com/articles/cr201126.pdf
Dynamics of inherently bounded histone modification domains, Proc. Natl. Acad. Sci. USA, vol.109, pp.13296-13301, 2012. ,
DOI : 10.1073/pnas.1211172109
URL : http://www.pnas.org/content/109/33/13296.full.pdf
Inheritance of epigenetic chromatin silencing, J Theor Biol, vol.258, pp.112-120, 2009. ,
DOI : 10.1016/j.jtbi.2008.12.021
URL : http://europepmc.org/articles/pmc3034166?pdf=render
A two-state activation mechanism controls the histone methyltransferase Suv39h1, Nat. Chem. Biol, vol.12, pp.188-193, 2016. ,
Rippe, Specificity, propagation, and memory of pericentric heterochromatin, Mol. Syst. Biol, vol.10, p.746, 2014. ,
Generalized nucleation and looping model for epigenetic memory of histone modifications, Proc. Natl. Acad. Sci. USA, vol.113, pp.4180-4189, 2016. ,
DOI : 10.1073/pnas.1605862113
URL : http://www.pnas.org/content/113/29/E4180.full.pdf
Conserved antagonism between JMJD2A/KDM4A and HP1? during cell cycle progression, Mol. Cell, vol.40, pp.736-748, 2010. ,
CDK2dependent phosphorylation of Suv39H1 is involved in control of heterochromatin replication during cell cycle progression, Nucl. Acids Res, vol.42, pp.6196-6207, 2014. ,
A glue for heterochromatin maintenance: stable SUV39H1 binding to heterochromatin is reinforced by the SET domain, J. Cell. Biol, vol.170, pp.537-549, 2005. ,
Methylation of histone H3 lysine 9 creates a binding site for HP1 proteins, Nature, vol.410, pp.116-120, 2001. ,
Selective recognition of methylated lysine 9 on histone H3 by the HP1 chromo domain, Nature, vol.410, pp.120-124, 2001. ,
Grewal, Role of histone H3 lysine 9 methylation in epigenetic control of heterochromatin assembly, Science, vol.292, pp.110-113, 2001. ,
Role of Swi6/HP1 self-association-mediated recruitment of Clr4/Suv39 in establishment and maintenance of heterochromatin in fission yeast, J. Biol. Chem, vol.286, pp.9308-9320, 2011. ,
, Crystal structure of the human SUV39H1 chromodomain and its recognition of histone H3K9me2/3, vol.7, p.52977, 2012.
Structure-function analysis of SUV39H1 reveals a dominant role in heterochromatin organization, chromosome segregation, and mitotic progression, Mol. Cell Biol, vol.20, pp.3728-3741, 2000. ,
Chromodomain-mediated oligomerization of HP1 suggests a nucleosome-bridging mechanism for heterochromatin assembly, Mol. Cell, vol.41, pp.67-81, 2011. ,
Affinity, stoichiometry and cooperativity of heterochromatin protein 1 (HP1) binding to nucleosomal arrays, J. Phys. Condens. Matter, vol.27, p.64110, 2015. ,
Thermodynamic model of heterochromatin formation through epigenetic regulation, J. Phys. Condens. Matter, vol.27, p.64109, 2015. ,
Human heterochromatin protein 1? promotes nucleosome associations that drive chromatin condensation, J. Biol. Chem, vol.289, pp.6850-6861, 2014. ,
Impact of receptor clustering on ligand binding, BMC Syst. Biol, vol.5, p.48, 2011. ,
Effect of nonspecific forces and finite receptor number on rate constants of ligand-cell bound-receptor interactions, Proc. Natl. Acad. Sci. USA, vol.78, pp.5569-5572, 1981. ,
Competition between solution and cell surface receptors for ligand. Dissociation of hapten bound to surface antibody in the presence of solution antibody, Biophys. J, vol.56, pp.955-966, 1989. ,
Approximating the effects of diffusion on reversible reactions at the cell surface: ligandreceptor kinetics, Biophys. J, vol.68, pp.1222-1230, 1995. ,
Effects of receptor clustering on ligand dissociation kinetics: theory and simulations, Biophys. J, vol.89, pp.3686-3700, 2005. ,
Theory for ligand rebinding at cell membrane surfaces, Biophys. J, vol.74, pp.1215-1228, 1998. ,
Role of diffusion in ligand binding to macromolecules and cell-bound receptors, Biophys. J, vol.40, pp.33-39, 1982. ,
Catalytic properties and kinetic mechanism of human recombinant Lys-9 histone H3 methyltransferase SUV39H1: participation of the chromodomain in enzymatic catalysis, Biochemistry, vol.45, pp.3272-3284, 2006. ,
Jmjd2b antagonizes H3K9 trimethylation at pericentric heterochromatin in mammalian cells, Genes Dev, vol.20, pp.1557-1562, 2006. ,
DOI : 10.1101/gad.388206
URL : http://genesdev.cshlp.org/content/20/12/1557.full.pdf
Histone methyltransferases direct different degrees of methylation to define distinct chromatin domains, Mol. Cell, vol.12, pp.1591-1598, 2003. ,
DOI : 10.1016/s1097-2765(03)00479-9
URL : https://doi.org/10.1016/s1097-2765(03)00479-9
When metabolism and epigenetics converge, Science, vol.339, pp.148-150, 2013. ,
DOI : 10.1126/science.1233423
Molecular crowding affects diffusion and binding of nuclear proteins in heterochromatin and reveals the fractal organization of chromatin, EMBO J, vol.28, pp.3785-3798, 2009. ,
Dissecting chromatin interactions in living cells from protein mobility maps, Chromosome Res, vol.19, pp.99-115, 2011. ,
DOI : 10.1007/s10577-010-9155-6
URL : https://link.springer.com/content/pdf/10.1007%2Fs10577-010-9155-6.pdf
Macromolecular crowding: an important but neglected aspect of the intracellular environment, Curr. Opin. Struct. Biol, vol.11, pp.114-119, 2001. ,
DOI : 10.1016/s0959-440x(00)00239-6
Pericentric H3K9me3 formation by HP1 interaction-defective histone methyltransferase Suv39h1, Cell. Struct. Funct, 2016. ,
DOI : 10.1247/csf.16013
URL : https://www.jstage.jst.go.jp/article/csf/41/2/41_16013/_pdf
A simple model for DNA bridging proteins and bacterial or human genomes: bridging-induced attraction and genome compaction, J. Phys. Condens. Matter, vol.27, p.64119, 2015. ,
DOI : 10.1088/0953-8984/27/6/064119
URL : https://www.pure.ed.ac.uk/ws/files/24472450/JPCM15JohnsonAccepted.pdf
Nonspecific bridging-induced attraction drives clustering of DNA-binding proteins and genome organization, Proc. Natl. Acad. Sci. USA, vol.110, pp.3605-3616, 2013. ,
DOI : 10.1073/pnas.1302950110
URL : http://www.pnas.org/content/110/38/E3605.full.pdf
Ultrasensitive gene regulation by positive feedback loops in nucleosome modification, Mol. Syst. Biol, vol.4, p.182, 2008. ,
DOI : 10.1038/msb.2008.21
URL : http://msb.embopress.org/content/4/1/182.full.pdf
Large-scale dissociation and sequential reassembly of pericentric heterochromatin in dedifferentiated Arabidopsis cells, J. Cell. Sci, vol.120, pp.1200-1208, 2007. ,
DOI : 10.1242/jcs.000026
URL : http://jcs.biologists.org/content/120/7/1200.full.pdf
Conspiracy of silence among repeated transgenes, BioEssays, vol.20, pp.532-535, 1998. ,
DOI : 10.1002/(sici)1521-1878(199807)20:7<532::aid-bies3>3.0.co;2-m
Tandem repetitive transgenes and fluorescent chromatin tags alter local interphase chromosome arrangement in Arabidopsis thaliana, J. Cell. Sci, vol.118, pp.3751-3758, 2005. ,
DOI : 10.1242/jcs.02498
URL : http://jcs.biologists.org/content/118/16/3751.full.pdf
Global heterochromatin loss: a unifying theory of aging, Epigenetics, vol.7, pp.680-688, 2012. ,
DOI : 10.4161/epi.20540
URL : http://www.tandfonline.com/doi/pdf/10.4161/epi.20540?needAccess=true
Global quantification of mammalian gene expression control, Nature, vol.473, pp.337-342, 2011. ,
Stabilization of Suv39H1 by SirT1 is part of oxidative stress response and ensures genome protection, Mol. Cell, vol.42, pp.210-223, 2011. ,
High local concentration: a fundamental strategy of life, J. Mol. Biol, vol.395, pp.242-253, 2010. ,
DOI : 10.1016/j.jmb.2009.10.056
Modeling generic aspects of ideal fibril formation, J. Chem. Phys, vol.144, p.35101, 2016. ,
DOI : 10.1063/1.4940149
URL : https://hal.archives-ouvertes.fr/hal-01263103
p53 promotes repair of heterochromatin DNA by regulating JMJD2b and SUV39H1 expression, Oncogene, vol.33, pp.734-744, 2013. ,
DOI : 10.1038/onc.2013.6
URL : http://europepmc.org/articles/pmc3912226?pdf=render
SIRT1 regulates the histone methyl-transferase SUV39H1 during heterochromatin formation, Nature, vol.450, pp.440-444, 2007. ,
The actin/MKL1 signalling pathway influences cell growth and gene expression through large-scale chromatin reorganization and histone post-translational modifications, Biochem. J, vol.461, pp.257-268, 2014. ,
URL : https://hal.archives-ouvertes.fr/hal-01063933
Activity and specificity of the human SUV39H2 protein lysine methyltransferase, Biochim. Biophys. Acta, vol.1849, pp.55-63, 2015. ,
Structural and evolutionary basis for the dual substrate selectivity of human KDM4 histone demethylase family, J. Biol. Chem, vol.286, pp.41616-41625, 2011. ,
Structural and functional analysis of JMJD2D reveals molecular basis for site-specific demethylation among JMJD2 demethylases, Structure, vol.21, pp.98-108, 2013. ,
Rippe, Specificity, propagation, and memory of pericentric heterochromatin, Mol. Syst. Biol, vol.10, p.746, 2014. ,
Vaquero, Stabilization of Suv39H1 by SirT1 is part of oxidative stress response and ensures genome protection, Mol. Cell, vol.42, pp.210-223, 2011. ,
RNF8-and RNF168-dependent degradation of KDM4A/JMJD2A triggers 53BP1 recruitment to DNA damage sites, EMBO J, vol.31, pp.1865-1878, 2012. ,
Jmjd2b antagonizes H3K9 trimethylation at pericentric heterochromatin in mammalian cells, Genes Dev, vol.20, pp.1557-1562, 2006. ,
SCF F BXO22 regulates histone H3 lysine 9 and 36 methylation levels by targeting histone demethylase KDM4A for ubiquitinmediated proteasomal degradation, Mol. Cell. Biol, vol.31, pp.3687-3699, 2011. ,
A coding single nucleotide polymorphism in lysine demethylase KDM4A increases sensitivity to mTOR inhibitors, Cancer Discov, vol.5, pp.245-254, 2015. ,
Heat Shock Protein 90 (Hsp90) selectively regulates the stability of KDM4B/JMJD2B histone demethylase, J. Biol. Chem, vol.288, pp.14681-14687, 2013. ,
Transient JMJD2B-mediated reduction of H3K9me3 levels improves reprogramming of embryonic stem cells into cloned embryos, Mol. Cell. Biol, vol.33, pp.974-983, 2013. ,
SCAI acts as a suppressor of cancer cell invasion through the transcriptional control of beta1-integrin, Nat Cell Biol, vol.11, pp.557-568, 2009. ,
/ Epithelial cell-cell contacts regulate SRF-mediated transcription via Rac-actin-MAL signalling, J. Cell. Sci, vol.121, pp.1025-1035, 2008. ,
Histone lysine methyltransferase SUV39H1 is a potent target for epigenetic therapy of hepatocellular carcinoma, Int. J. Cancer, vol.136, pp.289-298, 2014. ,
Reciprocal control of cell proliferation and migration, Cell. Commun. Signal, vol.8, p.20, 2010. ,
Interaction with Suv39H1 is critical for Snail-mediated E-cadherin repression in breast cancer, Oncogene, vol.32, pp.1351-1362, 2013. ,
,
Meshorer, Global transcription in pluripotent embryonic stem cells, Cell Stem Cell, vol.2, pp.437-447, 2008. ,
Rho-actin signaling to the MRTF coactivators dominates the immediate transcriptional response to serum in fibroblasts, Genes Dev, vol.28, pp.943-958, 2014. ,
MKL1 is an epigenetic modulator of TGF-? induced fibrogenesis, Biochim. Biophys. Acta, vol.1849, pp.1219-1228, 2015. ,
The actin/MKL1 signalling pathway influences cell growth and gene expression through large-scale chromatin reorganization and histone posttranslational modifications, Biochem. J, vol.461, pp.257-268, 2014. ,
URL : https://hal.archives-ouvertes.fr/hal-01063933
RPEL motifs link the serum response factor cofactor MAL but not myocardin to Rho signaling via actin binding, Mol. Cell. Biol, vol.28, pp.732-742, 2008. ,
The hallmarks of cancer, Cell, vol.100, pp.57-70, 2000. ,
Distinct epigenomic landscapes of pluripotent and lineage-committed human cells, Cell Stem Cell, vol.6, pp.479-491, 2010. ,
Dynamics and memory of heterochromatin in living cells, Cell, vol.149, pp.1447-1460, 2012. ,
An overview of epithelio-mesenchymal transformation, Acta Anat (Basel), vol.154, pp.8-20, 1995. ,
Protein phosphorylated by the RSV transforming function, Cell, vol.22, pp.647-648, 1980. ,
Regulation of myocardin factor protein stability by the LIM-only protein FHL2, Am. J. Physiol. Heart Circ. Physiol, vol.295, pp.1067-1075, 2008. ,
Reprogramming of a melanoma genome by nuclear transplantation, Genes Dev, vol.18, pp.1875-1885, 2004. ,
Myocardin is required for cardiomyocyte survival and maintenance of heart function, Proc. Natl. Acad. Sci. USA, vol.106, pp.18734-18739, 2009. ,
A non-genetic basis for cancer progression and metastasis : self-organizing attractors in cell regulatory networks, Breast Disease, vol.26, pp.27-54, 2006. ,
On the intrinsic inevitability of cancer : from foetal to fatal attraction, Semin. Cancer Biol, vol.21, pp.183-199, 2011. ,
The molecular and mathematical basis of Waddington's epigenetic landscape : a framework for postDarwinian biology, Bioessays, vol.34, pp.149-157, 2012. ,
An epigenetic switch involving NF-kappaB, Lin28, Let-7 MicroRNA, and IL6 links inflammation to cell transformation, Cell, vol.139, pp.693-706, 2009. ,
The basics of epithelialmesenchymal transition, J. Clin. Invest, vol.119, pp.1420-1428, 2009. ,
The origins of order : self-organization and selection in evolution, 1993. ,
Prolyl isomerase Pin1 negatively regulates the stability of SUV39H1 to promote tumorigenesis in breast cancer, FASEB J, vol.27, pp.4606-4618, 2013. ,
Myocardin functions as an effective inducer of growth arrest and differentiation in human uterine leiomyosarcoma cells, Cancer Res, vol.70, pp.501-511, 2010. ,
Biological responses to TGF-? in the mammary epithelium show a complex dependency on Smad3 gene dosage with important implications for tumor progression, Mol. Cancer Res, vol.10, pp.1389-1399, 2012. ,
The epigenomics of embryonic stem cell differentiation, Int. J. Biol. Sci, vol.9, pp.1134-1144, 2013. ,
MAL/MRTF-A controls migration of non-invasive cells by upregulation of cytoskeleton-associated proteins, J. Cell. Sci, vol.124, pp.4318-4331, 2011. ,
Jmjd1a and Jmjd2c histone H3 Lys 9 demethylases regulate self-renewal in embryonic stem cells, Genes Dev, vol.21, pp.2545-2557, 2007. ,
Myocardin is sufficient for a smooth musclelike contractile phenotype, Arterioscler. Thromb. Vasc. Biol, vol.28, pp.1505-1510, 2008. ,
Embryonic development following somatic cell nuclear transfer impeded by persisting histone methylation, Cell, vol.159, pp.884-895, 2014. ,
Genome-scale epigenetic reprogramming during epithelial-to-mesenchymal transition, Nat. Struct. Mol. Biol, vol.18, pp.867-874, 2011. ,
Signaling mechanisms that regulate smooth muscle cell differentiation, Atherioscler. Thromb. Vasc. Biol, vol.31, pp.1495-1505, 2011. ,
Myocardin-related transcription factors and SRF are required for cytoskeletal dynamics and experimental metastasis, Nat. Cell. Biol, vol.11, pp.257-268, 2009. ,
Chromatin in pluripotent embryonic stem cells and differentiation, Nat. Rev. Mol. Cell. Biol, vol.7, pp.540-546, 2006. ,
Inactivation of myocardin and p16 during malignant transformation contributes to a differentiation defect, Cancer Cell, vol.11, pp.133-146, 2007. ,
Actin dynamics control SRF activity by regulation of its coactivator MAL, Cell, vol.113, pp.329-342, 2003. ,
Dual roles of myocardin-related transcription factors in epithelial mesenchymal transition via slug induction and actin remodeling, J. Cell. Biol, vol.179, pp.1027-1042, 2007. ,
Structure of a pentavalent Gactin*MRTF-A complex reveals how G-actin controls nucleocytoplasmic shuttling of a transcriptional coactivator, Sci. Signal, vol.4, p.40, 2011. ,
Cell density sensing alters TGF-? signaling in a cell-type-specific manner, independent from Hippo pathway activation, Dev. Cell, vol.32, pp.640-651, 2015. ,
Reprogramming of human fibroblasts toward a cardiac fate, Proc. Natl. Acad. Sci. USA, vol.110, pp.5588-5593, 2013. ,
Epigenetic memories : structural marks or active circuits ?, Cell. Mol. Life Sci, vol.69, pp.2189-2203, 2012. ,
URL : https://hal.archives-ouvertes.fr/hal-01063617
Drawing a Waddington landscape to capture dynamic epigenetics, Biol. Cell, vol.105, pp.576-584, 2013. ,
URL : https://hal.archives-ouvertes.fr/inserm-00920766
Epithelial plasticity : a common theme in embryonic and cancer cells, Science, vol.342, p.1234850, 2013. ,
Cell adhesion and shape regulate TGF-beta1-induced epithelial-myofibroblast transition via MRTF-A signaling, PLoS One, vol.8, p.83188, 2013. ,
Matrix rigidity mediates TGF?1-induced epithelial-myofibroblast transition by controlling cytoskeletal organization and MRTF-A localization, J. Cell. Physiol, vol.230, pp.1829-1839, 2015. ,
Linking actin dynamics and gene transcription to drive cellular motile functions, Nat. Rev. Mol. Cell. Biol, vol.11, pp.353-365, 2010. ,
DOI : 10.1038/nrm2890
URL : http://europepmc.org/articles/pmc3073350?pdf=render
The disappearing Barr body in breast and ovarian cancers, Nat. Rev. Cancer, vol.7, pp.628-633, 2007. ,
DOI : 10.1038/nrc2172
Immortalization and malignant transformation of differentiated cells by oncogenes in vitro and in transgenic mice, Crit. Rev. Oncog, vol.1, pp.307-321, 1989. ,
Non-genetic cancer cell plasticity and therapy-induced stemness in tumour relapse : 'What does not kill me strengthens me, Br. J. Cancer, vol.112, pp.1725-1732, 2015. ,
DOI : 10.1038/bjc.2015.146
URL : https://www.nature.com/articles/bjc2015146.pdf
Seeding and propagation of untransformed mouse mammary cells in the lung, Science, vol.321, pp.1841-1844, 2008. ,
The cellular basis of metastasis, World J. Urol, vol.14, pp.141-150, 1996. ,
The core and conserved role of MAL is homeostatic regulation of actin levels, Genes Dev, vol.28, pp.1048-1053, 2014. ,
Asparuhova, Megakaryoblastic leukemia protein-1 (MKL1) : Increasing evidence for an involvement in cancer progression and metastasis, Int. J. Biochem. Cell. Biol, vol.42, pp.1911-1914, 2010. ,
DOI : 10.1016/j.biocel.2010.08.014
RhoA as a mediator of clinically relevant androgen action in prostate cancer cells, Mol. Endocrinol, vol.26, pp.716-735, 2012. ,
Megakaryoblastic leukemia1/2, a transcriptional co-activator of serum response factor, is required for skeletal myogenic differentiation, J. Biol. Chem, vol.278, pp.41977-41987, 2003. ,
DOI : 10.1074/jbc.m305679200
URL : http://www.jbc.org/content/278/43/41977.full.pdf
Expression profiling of serum inducible genes identifies a subset of SRF target genes that are MKL dependent, BMC Mol. Biol, vol.5, p.13, 2004. ,
Differential topical susceptibility to TGF ? in intact and injured regions of the epithelium : key role in myofibroblast transition, Mol. Biol. Cell, vol.24, pp.3326-3336, 2013. ,
Conrad Hal Waddington : the last Renaissance biologist ?, Nat. Rev. Genet, vol.3, pp.889-895, 2002. ,
DOI : 10.1038/nrg933
The epigenetics of epithelial-mesenchymal plasticity in cancer, Nat. Med, vol.19, pp.1438-1449, 2013. ,
Transforming growth factor-beta and the hallmarks of cancer, Cell Signal, vol.23, pp.951-962, 2011. ,
Cancer etiology. Variation in cancer risk among tissues can be explained by the number of stem cell divisions, Science, vol.347, pp.78-81, 2015. ,
Energy metabolism in human pluripotent stem cells and their differentiated counterparts, PLoS One, vol.6, p.20914, 2011. ,
DOI : 10.1371/journal.pone.0020914
URL : https://doi.org/10.1371/journal.pone.0020914
Epithelial expression of FHL2 is negatively associated with metastasis-free and overall survival in colorectal cancer, Br. J. Cancer, vol.109, pp.114-120, 2013. ,
Cancer genome landscapes, Science, vol.339, pp.1546-1558, 2013. ,
DOI : 10.1126/science.1235122
URL : http://science.sciencemag.org/content/339/6127/1546.full.pdf
Activation of cardiac gene expression by myocardin, a transcriptional cofactor for serum response factor, Cell, vol.105, pp.851-862, 2001. ,
Potentiation of serum response factor activity by a family of myocardin-related transcription factors, Proc. Natl. Acad. Sci. USA, vol.99, pp.14855-14860, 2002. ,
Myocardin is a master regulator of smooth muscle gene expression, Proc. Natl. Acad. Sci. USA, vol.100, pp.7129-7134, 2003. ,
DOI : 10.1073/pnas.1232341100
URL : http://www.pnas.org/content/100/12/7129.full.pdf
Myocardin and ternary complex factors compete for SRF to control smooth muscle gene expression, Nature, vol.428, pp.185-189, 2004. ,
DOI : 10.1038/nature02382
Adhesion regulates MAP kinase/ternary complex factor exchange to control a proliferative transcriptional switch, Curr. Biol, vol.22, pp.2017-2026, 2012. ,
DOI : 10.1016/j.cub.2012.08.050
URL : https://doi.org/10.1016/j.cub.2012.08.050
Upregulated SMAD3 promotes epithelial-mesenchymal transition and predicts poor prognosis in pancreatic ductal adenocarcinoma, Lab. Invest, vol.94, pp.683-691, 2014. ,
DOI : 10.1038/labinvest.2014.53
URL : https://www.nature.com/articles/labinvest201453.pdf
MKL1 inhibits cell cycle progression through p21 in podocytes, BMC Mol. Biol, vol.12, p.1, 2015. ,
DOI : 10.1186/s12867-015-0029-5
URL : https://bmcmolbiol.biomedcentral.com/track/pdf/10.1186/s12867-015-0029-5
Distinct EMT programs control normal mammary stem cells and tumourinitiating cells, Nature, vol.525, pp.256-260, 2015. ,
DOI : 10.1038/nature14897
URL : http://europepmc.org/articles/pmc4764075?pdf=render
Cancer-associated upregulation of histone H3 lysine 9 trimethylation promotes cell motility in vitro and drives tumor formation in vivo, Cancer Sci, vol.104, pp.889-895, 2013. ,
MAL and ternary complex factor use different mechanisms to contact a common surface on the serum response factor DNAbinding domain, Mol. Cell. Biol, vol.26, pp.4134-4148, 2006. ,
DOI : 10.1128/mcb.01902-05
URL : http://mcb.asm.org/content/26/11/4134.full.pdf
Biomarkers for epithelialmesenchymal transitions, J. Clin. Invest, vol.119, pp.1429-1437, 2009. ,
Expression of luminal and basal cytokeratins in human breast carcinoma, J Pathol, vol.203, pp.661-671, 2004. ,
Palmitoylation-dependent estrogen receptor alpha membrane localization: regulation by 17beta-estradiol, Mol Biol Cell, vol.16, pp.231-237, 2005. ,
DOI : 10.1091/mbc.e04-07-0547
URL : http://europepmc.org/articles/pmc539167?pdf=render
Mutation of the palmitoylation site of estrogen receptor in vivo reveals tissue-specific roles for membrane versus nuclear actions, Proc Natl Acad Sci, vol.111, 2014. ,
URL : https://hal.archives-ouvertes.fr/inserm-01015486
Obesity and Menopause, Best Pract Res Clin Obstet Gynaecol, vol.29, pp.548-553, 2015. ,
HIF2? contributes to antiestrogen resistance via positive bilateral crosstalk with EGFR in breast cancer cells, Oncotarget, 2016. ,
DOI : 10.18632/oncotarget.7167
URL : http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=download&path%5B%5D=7167&path%5B%5D=20415
Postmenopausal osteoporosis: Its clinical features, J Am Med Assoc, vol.116, pp.2465-2474, 1941. ,
Modulation of transcriptional activation by liganddependent phosphorylation of the human oestrogen receptor A/B region, EMBO, vol.12, pp.1153-1160, 1993. ,
The Mediator complex: a central integrator of transcription, Nat Rev Mol Cell Biol, vol.16, pp.155-166, 2015. ,
Pancreatic insulin content regulation by the Estrogen receptor ER?, PLoS One, 2008. ,
Lack of evidence for the involvement of the phosphoinositide 3-kinase/Akt pathway in the activation of hypoxia-inducible factors by low oxygen tension, J Biol Chem, vol.277, pp.13508-13517, 2002. ,
Cooperative Binding of Estrogen Receptor to DNA Depends on Spacing of Binding Sites, Flanking Sequence, and Ligand, Biochemistry, vol.34, pp.2511-2520, 1995. ,
AIB1, a steroid receptor coactivator amplified in breast and ovarian cancer, Science (80-), vol.277, pp.965-968, 1997. ,
Membrane and Nuclear Estrogen Receptor Alpha Actions: From Tissue Specificity to Medical Implications, Physiol Rev, vol.97, pp.1045-1087, 2017. ,
URL : https://hal.archives-ouvertes.fr/hal-01533249
Estrogen receptors and endothelium, Arterioscler. Thromb. Vasc. Biol, vol.30, pp.1506-1512, 2010. ,
URL : https://hal.archives-ouvertes.fr/inserm-00504272
Estrogen receptor actions on vascular biology and inflammation: implications in vascular pathophysiology, Climacteric, vol.12, pp.12-19, 2009. ,
URL : https://hal.archives-ouvertes.fr/inserm-00512765
Placental cadherin and the basal epithelial phenotype of BRCA1-related breast cancer, Clin Cancer Res, vol.11, pp.4003-4011, 2005. ,
Serum response factor is essential for mesoderm formation during mouse embryogenesis, EMBO J, vol.17, pp.6289-6299, 1998. ,
Phosphatidylinositol 3-kinase/Akt signaling is neither required for hypoxic stabilization of HIF-1? nor sufficient for HIF-1-dependent target gene transcription, J Biol Chem, vol.277, pp.15162-15170, 2002. ,
Akt and hypoxia-inducible factor-1 independently enhance tumor growth and angiogenesis, Cancer Res, vol.64, pp.3500-3507, 2004. ,
Gata-3 is an essential regulator of mammarygland morphogenesis and luminal-cell differentiation, Nat Cell Biol, vol.9, pp.201-209, 2007. ,
Delineating the epithelial hierarchy in the mouse mammary gland, Cold Spring Harbor Symposia on Quantitative Biology, pp.469-478, 2008. ,
Systematic mapping of posttranslational modifications in human estrogen receptor-alpha with emphasis on novel phosphorylation sites, Mol Cell Proteomics, vol.8, pp.467-480, 2009. ,
Direct evidence of in vitro phosphorylationdephosphorylation of the estradiol-17?? receptor. role of Ca2+-Calmodulin in the activation of hormone binding sites, J Steroid Biochem, vol.20, pp.31-35, 1984. ,
Oestradiol stimulates tyrosine phosphorylation and hormone binding activity of its own receptor in a cell-free system, 1987. ,
Nuclear actin network assembly by formins regulates the SRF coactivator MAL, Science, vol.340, pp.864-871, 2013. ,
Basal-like and triple-negative breast cancers: a critical review with an emphasis on the implications for pathologists and oncologists, Mod Pathol, vol.24, pp.157-167, 2011. ,
FOXO3a Is Activated in Response to Hypoxic Stress and Inhibits HIF1-Induced Apoptosis via Regulation of CITED2, Mol Cell, vol.28, pp.941-953, 2007. ,
Inhibition of skeletal metastasis by ectopic ERalpha expression in ERalpha-negative human breast cancer cell lines, Neoplasia, vol.9, pp.113-121, 2007. ,
Buparlisib plus fulvestrant versus placebo plus fulvestrant in postmenopausal, hormone receptor-positive, HER2-negative, advanced breast cancer (BELLE-2): a randomised, double-blind, placebo-controlled, p.242, 2017. ,
Targeting of SWI/SNF chromatin remodelling complexes to estrogen-responsive genes, EMBO J, vol.21, pp.4094-4103, 2002. ,
RhoA protein expression in primary breast cancers and matched lymphocytes is associated with progression of the disease, Int J Mol Med, vol.22, pp.25-31, 2008. ,
Estrogen-dependent, tamoxifen-resistant tumorigenic growth of MCF-7 cells transfected with HER2/neu, Breast Cancer Res Treat, vol.24, pp.85-95, 1992. ,
DOI : 10.1007/bf01961241
FOXA1 is an essential determinant of ER expression and mammary ductal morphogenesis, Development, vol.137, pp.2045-2054, 2010. ,
DOI : 10.1242/dev.043299
URL : http://dev.biologists.org/content/137/12/2045.full.pdf
Role of the two activating domains of the oestrogen receptor in the cell-type and promoter-context dependent agonistic activity of the anti-oestrogen 4hydroxytamoxifen, EMBO J, vol.9, pp.2811-2818, 1990. ,
Activation of ROCK by RhoA is regulated by cell adhesion, shape, and cytoskeletal tension, Exp Cell Res, vol.313, pp.3616-3623, 2007. ,
DOI : 10.1016/j.yexcr.2007.07.002
URL : http://europepmc.org/articles/pmc2064860?pdf=render
The transactivating function 1 of estrogen receptor alpha is dispensable for the vasculoprotective actions of 17beta-estradiol, Proc Natl Acad Sci U S A, vol.106, pp.2053-2061, 2009. ,
The mediator of RNA polymerase II, Chromosoma, vol.113, pp.399-408, 2005. ,
The contribution of the N-and C-terminal regions of steroid receptors to activation of transcription is both receptor and cell-specific, Nucleic Acids Res, vol.17, pp.2581-2595, 1989. ,
Differential estrogen-regulation of CXCL12 chemokine receptors, CXCR4 and CXCR7, contributes to the growth effect of estrogens in breast cancer cells, PLoS One, 2011. ,
URL : https://hal.archives-ouvertes.fr/hal-00605459
Estrogen receptor alpha mediates epithelial to mesenchymal transition, expression of specific matrix effectors and functional properties of breast cancer cells, Matrix Biol, vol.43, pp.42-60, 2015. ,
Angiotensin II induces RhoA activation through SHP2-dependent dephosphorylation of the RhoGAP p190A in vascular smooth muscle cells, Am J Physiol Cell Physiol, vol.297, 2009. ,
Hooe aatio i the aa glaad. Cold Spig Haa, Peespeet. Biol, vol.2 ,
Bidirectional cross talk between ER?? and EGFR signalling pathways regulates tamoxifen-resistant growth, Breast Cancer Res Treat, vol.96, pp.131-146, 2006. ,
DOI : 10.1007/s10549-005-9070-2
A Biobank of Breast Cancer Explants with Preserved Intra-tumor Heterogeneity to Screen Anticancer Compounds, Cell, vol.167, pp.260-274, 2016. ,
DOI : 10.1016/j.cell.2016.08.041
URL : https://doi.org/10.1016/j.cell.2016.08.041
Activation of the unliganded estrogen receptor by EGF involves the MAP kinase pathway and direct phosphorylation, EMBO J, vol.15, pp.2174-83, 1996. ,
Epithelial cell-cell contacts regulate SRF-mediated transcription via Rac-actin-MAL signalling, J Cell Sci, vol.121, pp.1025-1035, 2008. ,
DOI : 10.1242/jcs.014456
URL : http://jcs.biologists.org/content/121/7/1025.full.pdf
E-cadherin regulates MAL-SRF-mediated transcription in epithelial cells, J Cell Sci, vol.123, pp.2803-2812, 2010. ,
DOI : 10.1242/jcs.061887
URL : http://jcs.biologists.org/content/123/16/2803.full.pdf
The RNA polymerase II core promoter: a key component in the regulation of gene expression, Genes Dev, vol.16, pp.2583-2592, 2002. ,
Genome-wide activity of unliganded estrogen receptor-? in breast cancer cells, Proc Natl Acad Sci U S A, vol.111, pp.1-6, 2014. ,
DOI : 10.1073/pnas.1315445111
URL : http://www.pnas.org/content/111/13/4892.full.pdf
Phosphatidylinositol 3-kinase/AKT-mediated activation of estrogen receptor ?: A new model for anti-estrogen resistance, J Biol Chem, vol.276, pp.9817-9824, 2001. ,
Race, Breast Cancer Subtypes, and Survival in the Carolina Breast Cancer Study, JAMA, vol.295, p.2492, 2006. ,
Role of HIF-1alpha in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis, Nature, vol.394, pp.485-90, 1998. ,
Synergism between vascular endothelial growth factor and placental growth factor contributes to angiogenesis and plasma extravasation in pathological conditions, Nat Med, vol.7, pp.575-83, 2001. ,
Genome-wide analysis of estrogen receptor binding sites, Nat Genet, vol.38, pp.1289-1297, 2006. ,
Steroid receptor family: structure and functions, Endocr Rev, vol.11, pp.201-220, 1990. ,
Cyclin D1 Determines Estrogen Signaling in the Mammary Gland In Vivo, Mol Endocrinol, vol.27, pp.1415-1428, 2013. ,
Insulin-like growth factor-1 and 17Betaestradiol down-regulate prostate apoptosis response-4 expression in MCF-7 breast cancer cells, Int J Mol Med, vol.28, pp.337-342, 2011. ,
PI3-kinase in concert with Src promotes the S-phase entry of oestradiol-stimulated MCF-7 cells, EMBO J, vol.20, pp.6050-6059, 2001. ,
beta-estradiol regulation of human endothelial cell basal nitric oxide release, independent of cytosolic Ca2+ mobilization, Circ Res, vol.17, pp.885-892, 1997. ,
Molecular changes associated with the acquisition of oestrogen hypersensitivity in MCF-7 breast cancer cells on long-term oestrogen deprivation, J Steroid Biochem Mol Biol, vol.81, pp.333-341, 2002. ,
The AF-1-deficient estrogen receptor ER?46 isoform is frequently expressed in human breast tumors, Breast Cancer Res, vol.18, p.123, 2016. ,
Breast cancer stem cells: tools and models to rely on, BMC Cancer, vol.9, p.202, 2009. ,
URL : https://hal.archives-ouvertes.fr/hal-01431957
Breast cancer cell lines contain functional cancer stem sells with metastatic capacity and a distinct molecular signature, Cancer Res, vol.69, pp.1302-1313, 2009. ,
Estrogen receptor-alpha 36 mediates the antiapoptotic effect of estradiol in triple negative breast cancer cells via a membrane-associated mechanism, Biochim Biophys Acta-Mol Cell Res, vol.1843, pp.2796-2806, 2014. ,
Membrane estrogen signaling enhances tumorigenesis and metastatic potential of breast cancer cells via estrogen receptor-?36, 2012. ,
, J Biol Chem, vol.287, pp.7169-7181
Absence of estrogen receptor alpha (ESR1) gene amplification in a series of breast cancers in Taiwan, Virchows Arch, vol.464, pp.689-699, 2014. ,
MKL1 potentiates lung cancer cell migration and invasion by epigenetically activating MMP9 transcription. Oncogene 1-12, 2015. ,
Molecular Basis of Metastasis, N Engl J Med, vol.359, pp.2814-2823, 2008. ,
Role of estrogen receptors and Src signaling in mechanisms of bone metastasis by estrogen receptor positive breast cancers, J Transl Med, vol.15, p.97, 2017. ,
Hypoxic activation of unoccupied estrogen-receptor-alpha is mediated by hypoxia-inducible factor-1 alpha, J Steroid Biochem Mol Biol, vol.100, pp.18-23, 2006. ,
DOI : 10.1016/j.jsbmb.2006.03.002
Cobalt chloride-induced estrogen receptor alpha down-regulation involves hypoxia-inducible factor-1alpha in MCF-7 human breast cancer cells, Mol Endocrinol, vol.19, pp.1191-1199, 2005. ,
DOI : 10.1210/me.2004-0162
URL : https://academic.oup.com/mend/article-pdf/19/5/1191/10718079/mend1191.pdf
Amphiregulin is an essential mediator of estrogen receptor alpha function in mammary gland development, Proc Natl Acad Sci U S A, vol.104, pp.5455-60, 2007. ,
A genomic view of estrogen actions in human breast cancer cells by expression profiling of the hormone-responsive transcriptome, J. Mol. Endocrinol, vol.32, pp.719-775, 2004. ,
Valpoi aaid oeeoes hpoia-induced resistance to apoptosis, Oncol Rep, vol.27, pp.1219-1226 ,
Opening of compacted chromatin by early developmental transcription factors HNF3 (FoxA) and GATA-4, Mol Cell, vol.9, pp.459-467, 2002. ,
DOI : 10.1016/s1097-2765(02)00459-8
URL : https://doi.org/10.1016/s1097-2765(02)00459-8
Endocrine resistance in breast cancer-An overview and update, Mol Cell Endocrinol, vol.418, pp.220-234, 2015. ,
DOI : 10.1016/j.mce.2015.09.035
URL : http://europepmc.org/articles/pmc4684757?pdf=render
The putative oncogene GASC1 demethylates tri-and dimethylated lysine 9 on histone H3, Nature, vol.442, pp.307-311, 2006. ,
DOI : 10.1038/nature04837
Hypoxia-inducible factor-1-dependent regulation of the multidrug resistance (MDR1) gene, Cancer Res, vol.62, pp.3387-3394, 2002. ,
Intermittent hypoxia induces proteasome-dependent downregulation of estrogen receptor ? in human breast carcinoma, Clin Cancer Res, 2004. ,
DOI : 10.1158/1078-0432.ccr-04-1235
URL : http://clincancerres.aacrjournals.org/content/10/24/8720.full.pdf
The Diaphanous-related Formin mDia1 Controls Serum Response Factor Activity through its Effects on Actin Polymerization, Mol Biol Cell, vol.13, pp.4088-4099, 2002. ,
DOI : 10.1091/mbc.02-06-0092
URL : http://europepmc.org/articles/pmc133616?pdf=render
Estrogen receptor null mice: What have we learned and where will they lead us?, Endocr. Rev, vol.20, pp.358-417, 1999. ,
DOI : 10.1210/er.20.3.358
URL : https://academic.oup.com/edrv/article-pdf/20/3/358/8864683/edrv0358.pdf
Cross-talk between HER2 and MED1 regulates tamoxifen resistance of human breast cancer cells, Cancer Res, vol.72, pp.5625-5634, 2012. ,
DOI : 10.1158/0008-5472.can-12-1305
URL : http://cancerres.aacrjournals.org/content/72/21/5625.full.pdf
Targeting of the adaptor protein Tab2 as a novel approach to revert tamoxifen resistance in breast cancer cells, Oncogene, vol.31, pp.4420-4420, 2012. ,
The Biology of Cancer: Metabolic Reprogramming Fuels Cell Growth and Proliferation, Cell Metab, vol.7, pp.11-20, 2008. ,
Hypoxia-inducible factor-1?? protein expression is associated with poor survival in normal karyotype adult acute myeloid leukemia, Leuk Res, vol.35, pp.579-584, 2011. ,
DOI : 10.1016/j.leukres.2010.10.020
Impact of raloxifene or tamoxifen use on endometrial cancer risk: A population-based case-control study, J Clin Oncol, vol.26, pp.4151-4159, 2008. ,
Estrogen receptors ?1 and ?2 have opposing roles in regulating proliferation and bone metastasis genes in the prostate cancer cell line PC3, Mol Endocrinol, vol.26, pp.1991-2003, 2012. ,
Systematic Proteomic Identification of the Heat Shock Proteins (Hsp) that Interact with Estrogen Receptor Alpha (ER?) and Biochemical Characterization of the ER?-Hsp70 Interaction, PLoS One, vol.11, pp.1-19, 2016. ,
The mTOR and PP2A Pathways Regulate PHD2 Phosphorylation to Fine-Tune HIF1?? Levels and Colorectal Cancer Cell Survival under Hypoxia, Cell Rep, vol.18, pp.1699-1712, 2017. ,
Estrogen-induced factors of breast cancer cells partially replace estrogen to promote tumor growth, Science (80-), vol.232, pp.1540-1543, 1986. ,
Patient-derived xenograft (PDX) models in basic and translational breast cancer research, Cancer Metastasis Rev, vol.35, pp.547-573, 2016. ,
Estrogen and antiestrogen regulation of cell cycle progression in breast cancer cells, Endocrine-Related Cancer, pp.179-186, 2003. ,
Hypoxia-induced chemoresistance in cancer cells: The role of not only HIF-1, Biomed Pap, vol.159, pp.166-177, 2015. ,
In vitro analysis of Ah receptor domains involved in ligand-activated DNA recognition, Proc Natl Acad Sci U S A, vol.90, pp.8566-8570, 1993. ,
Chromosome Conformation Capture Carbon Copy (5C): A massively parallel solution for mapping interactions between genomic elements, Genome Res, vol.16, pp.1299-1309, 2006. ,
The role of estrogen in folliculogenesis, Mol. Cell. Endocrinol, vol.151, pp.57-64, 1999. ,
HIF1? Induces the Recruitment of Bone Marrow-Derived Vascular Modulatory Cells to Regulate Tumor Angiogenesis and Invasion, Cancer Cell, vol.13, pp.206-220, 2008. ,
Ligand-Independent Interactions of p160/Steroid Receptor Coactivators and CREB-Binding Protein (CBP) with Estrogen Receptor-?: Regulation by Phosphorylation Sites in the A/B Region Depends on Other Receptor Domains, Mol Endocrinol, vol.17, pp.1296-1314, 2003. ,
Positive cross-regulatory loop ties GATA-3 to estrogen eeepto ?? eepessio i east aaee. Caaee Res :-6483, 2007. ,
Purification and identification of p68 RNA helicase acting as a transcriptional coactivator specific for the activation function 1 of human estrogen receptor alpha, Mol Cell Biol, vol.19, pp.5363-72, 1999. ,
Estrogens as neuroprotectants: Estrogenic actions in the context of cognitive aging and brain injury, Prog. Neurobiol, 2015. ,
Ligand binding was acquired during evolution of nuclear receptors, Proc Natl Acad Sci U S A, vol.94, pp.6803-6808, 1997. ,
Acquired resistance to tamoxifen is associated with loss of the type I insulin-like growth factor receptor: Implications for breast cancer treatment, Cancer Res, vol.72, pp.3372-3380, 2012. ,
Crosstalk between IGF1R and estrogen receptor signaling in breast cancer, J. Mammary Gland Biol. Neoplasia, vol.13, pp.423-429, 2008. ,
EMT in Breast Carcinoma-A Review, J Clin Med, vol.5, p.65, 2016. ,
Hypoxia suppresses myocardial survival pathway through HIF-1?IGFBP-3-dependent signaling and enhances cardiomyocyte autophagic and apoptotic effects mainly via FoxO3a-induced BNIP3 expression, Growth Factors, vol.34, pp.73-86, 2016. ,
Hormone-Dependent Coactivator Binding to a Hydrophobic Cleft on Nuclear Receptors, Science (80-), vol.280, pp.1747-1749, 1998. ,
Estrogen receptor-alpha expression in the mammary epithelium is required for ductal and alveolar morphogenesis in mice, Proc Natl Acad Sci U S A, vol.104, pp.14718-14741, 2007. ,
Estrogen-Induced Activation of Erk-1 and Erk-2 Requires the G Protein-Coupled Receptor Homolog, GPR30, and Occurs via Trans-Activation of the Epidermal Growth Factor Receptor through Release of HB-EGF, Mol Endocrinol, vol.14, pp.1649-1660, 2000. ,
Estrogen Action Via the G Protein-Coupled Receptor, GPR30: Stimulation of Adenylyl Cyclase and cAMP-Mediated Attenuation of the Epidermal Growth Factor Receptor-to-MAPK Signaling Axis, Mol Endocrinol, vol.16, pp.70-84, 2002. ,
Targeting Src in breast cancer, Ann. Oncol, vol.19, pp.1379-1386, 2008. ,
Identification of a new isoform of the human estrogen receptor-alpha (hER-alpha) that is encoded by distinct transcripts and that is able to repress hERalpha activation function 1, EMBO J, vol.19, pp.4688-4700, 2000. ,
The actin/MKL1 signalling pathway influences cell growth and gene expression through large-scale chromatin reorganization and histone post-translational modifications, Biochem J, vol.461, pp.257-68, 2014. ,
URL : https://hal.archives-ouvertes.fr/hal-01063933
Phenotypic heterogeneity of disseminated tumour cells is preset by primary tumour hypoxic microenvironments, Nat Cell Biol, pp.1-6, 2017. ,
AIB1 is a conduit for kinase-mediated growth factor signaling to the estrogen receptor, Mol Cell Biol, vol.20, pp.5041-5048, 2000. ,
Metabolic impact of estrogen signalling through ERalpha and ERbeta, J. Steroid Biochem. Mol. Biol, vol.122, pp.74-81, 2010. ,
Estrogens Down-regulate p27Kip1 in Breast Cancer Cells through Skp2 and through Nuclear Export Mediated by the ERK Pathway, J Biol Chem, vol.278, pp.41355-41366, 2003. ,
FOXA1 overexpression mediates endocrine resistance by altering the ER transcriptome and IL-8 expression in ER-positive breast cancer, Proc Natl Acad Sci, vol.113, pp.6600-6609, 2016. ,
Estrogen-dependent downregulation of hypoxiainducible factor (HIF)-2` in invasive breast cancer cells, Oncotarget, 2016. ,
Mechanisms of resistance to endocrine 248 therapy in breast cancer: Focus on signaling pathways, miRNAs and genetically based resistance, Int. J. Mol. Sci, vol.14, pp.108-145, 2013. ,
Phosphorylated ERalpha, HIF-1alpha, and MAPK signaling as predictors of primary endocrine treatment response and resistance in patients with breast cancer, J Clin Oncol, vol.27, pp.227-261, 2009. ,
Estrogen Carcinogenesis in Breast Cancer, Endocrinol. Metab. Clin. North Am, vol.40, pp.473-484, 2011. ,
Hypoxia-inducible factors mediate coordinated RhoA-ROCK1 expression and signaling in breast cancer cells, Proc Natl Acad Sci U S A, vol.111, pp.384-93, 2014. ,
Expression analysis of estrogen receptor ? coregulators in breast carcinoma: Evidence that NCOR1 expression is predictive of the response to tamoxifen, Clin Cancer Res, vol.9, pp.1259-1266, 2003. ,
Overcoming Therapeutic Resistance in HER2-Positive Breast Cancers with CDK4/6 Inhibitors, Cancer Cell, vol.29, pp.255-269, 2016. ,
Chemical and biochemical issues related to Xray crystallography of the ligand-binding domain of estrogen receptor alpha, Bioconjug Chem, vol.12, pp.406-419, 2001. ,
Developmental biology of uterine glands, Biol Reprod, vol.65, pp.1311-1323, 2001. ,
Human oestrogen receptor cDNA: sequence, expression and homology to v-erb-A, Nature, vol.320, pp.134-143, 1986. ,
Involvement of caspase-9 but not caspase-8 in the anti-apoptotic effects of estradiol and 4-OH-Estradiol in MCF-7 human breast cancer cells, Endocr Regul, vol.45, pp.3-8, 2011. ,
Postmenopausal estrogen and progestin use and the risk of cardiovascular disease, N Engl J Med, vol.335, issue.18, p.1406, 1996. ,
, N Engl J Med, vol.335, pp.453-461
Estrogen receptor beta expression is associated with tamoxifen response in ERalpha-negative breast carcinoma, Clin Cancer Res, vol.13, pp.1987-94, 2007. ,
Sleep and sleep disorders in menopausal women, Climacteric, vol.16, pp.214-223, 2013. ,
Repression of the Estrogen Receptor-? Transcriptional Activity by the Rho/Megakaryoblastic Leukemia 1 Signaling Pathway, J Biol Chem, vol.284, pp.33729-33739, 2009. ,
Molecular subclasses of breast cancer: How do we define them? The IMPAKT 2012 working group statement, Ann. Oncol, vol.23, pp.2997-3006, 2012. ,
Slug and Sox9 cooperatively determine the mammary stem cell state, Cell, vol.148, pp.1015-1028, 2012. ,
Basal cytokeratins and their relationship to the cellular origin and functional classification of breast cancer, Breast Cancer Res, vol.7, pp.143-148, 2005. ,
Stromal cell-derived factor 1, a novel target of estrogen receptor action, mediates the mitogenic effects of estradiol in ovarian and breast cancer cells, Mol Endocrinol, vol.17, pp.792-803, 2003. ,
FOXC1: an emerging marker and therapeutic target for cancer, Oncogene, vol.36, pp.3957-3963, 2017. ,
The hallmarks of cancer, Cell, vol.100, pp.57-70, 2000. ,
, The Neet Geeeatio. Cell :-674
Estrogen receptor co-activator (AIB1) protein expression by automated quantitative analysis (AQUA) in a breast cancer tissue microarray and association with patient outcome, Breast Cancer Res Treat, vol.115, pp.77-85, 2009. ,
Estrogen Dendrimer Conjugates that Preferentially Activate Extranuclear, Nongenomic Versus Genomic Pathways of Estrogen Action, Mol Endocrinol, vol.20, pp.491-502, 2006. ,
Tumor repressive functions of esttogee eeepto ?? in SW480 colon cancer cells, Cancer Res, vol.69, pp.6100-6106, 2009. ,
Mediator Subunits MED1 and MED24 Cooperatively Contribute to Pubertal Mammary Gland Development and Growth of Breast Carcinoma Cells, Mol Cell Biol, vol.32, pp.1483-1495, 2012. ,
Distinct and predictive chromatin signatures of transcriptional promoters and enhancers in the human genome, Nat Genet, vol.39, pp.311-318, 2007. ,
pVHL-mediated degradation of HIF-2? regulates estrogen receptor ? expression in normoxic breast cancer cells, FEBS Lett, pp.2690-2699, 2016. ,
The Rho family GTPases RhoA, Rac1, and CDC42Hs regulate transcriptional activation by SRF, Cell, vol.81, pp.1159-1170, 1995. ,
Recruitment of HIF-1 alpha and HIF-2 alpha to common target genes is differentially regulated in neuroblastoma: HIF-2 alpha promotes an aggressive phenotype, Cancer Cell, vol.10, pp.413-423, 2006. ,
Induction of dormancy in hypoxic human papillomavirus-positive cancer cells, Proc Natl Acad Sci U S A, vol.114, pp.990-998, 2017. ,
LMO7 mediates cell-specific activation of the Rho-myocardin-related transcription factor-serum response factor pathway and plays an important role in breast cancer cell migration, Mol Cell Biol, vol.31, pp.3223-3263, 2011. ,
Structural overview of the nuclear receptor superfamily: insights into physiology and therapeutics, Annu Rev Physiol, vol.72, pp.247-72, 2010. ,
Loss of E-cadherin-mediated cell contacts reduces estrogen receptor alpha (ER?) transcriptional efficiency by affecting the respective contribution exerted by AF1 and AF2 transactivation functions, Biochem Biophys Res Commun, vol.365, pp.304-309, 2008. ,
URL : https://hal.archives-ouvertes.fr/hal-00195350
Inhibition of apoptosis by amphiregulin via an insulinlike growth factor-1 receptor-dependent pathway in non-small cell lung cancer cell lines, J Biol Chem, vol.277, pp.49127-49133, 2002. ,
FOXA1 is a key determinant of estrogen receptor function and endocrine response, Nat Genet, vol.43, pp.27-33, 2011. ,
Hypoxia enhances CXCR4 expression by activating HIF1 in oral squamous cell carcinoma, Oncol Rep, vol.21, pp.707-712, 2009. ,
N-Cadherin is a prospective cell surface marker of human mesenchymal stem cells that have high ability for cardiomyocyte differentiation, Biochem Biophys Res Commun, vol.438, pp.753-759, 2013. ,
Estrogen inhibits transforming growth factor ? signaling by promoting Smad2/3 degradation, J Biol Chem, vol.285, pp.14747-14755, 2010. ,
Clinical benefit of sequential use of endocrine therapies for metastatic breast cancer, Int. J. Clin. Oncol, vol.20, pp.253-261, 2015. ,
A model of dynamic stability of H3K9me3 heterochromatin to explain the resistance to reprogramming of differentiated cells, Biochim Biophys Acta-Gene Regul Mech, vol.1860, pp.184-195, 2017. ,
URL : https://hal.archives-ouvertes.fr/hal-01467548
Envisioning metastasis as a transdifferentiation phenomenon clarifies discordant results on cancer, Breast Dis, vol.36, pp.47-59, 2016. ,
URL : https://hal.archives-ouvertes.fr/hal-01367146
On the Mechanism of Estrogen Action, Perspect Biol Med, vol.6, pp.47-60, 1962. ,
Emergence of constitutively active estrogen receptor-? mutations in pretreated advanced estrogen receptor-positive breast cancer, Clin Cancer Res, vol.20, pp.1757-67, 2014. ,
Basal and therapy-driven hypoxia-inducible factor-1? confers resistance to endocrine therapy in estrogen receptor-positive breast, Oncotarget, vol.6, pp.8648-8662, 2015. ,
The multifunctional roles of the four-and-a-half-LIM only protein FHL2, Cell. Mol. Life Sci, vol.63, pp.268-284, 2006. ,
Hypoxia induces a novel signature of chromatin modifications and global repression of transcription, Mutat Res-Fundam Mol Mech Mutagen, vol.640, pp.174-179, 2008. ,
Antiestrogens and selective estrogen receptor modulators as multifunctional medicines. 1. Receptor interactions, J. Med. Chem, vol.46, pp.883-908, 2003. ,
MDM2 regulates hypoxic hypoxia-inducible factor 1? stability in an E3 ligase, proteasome, and PTEN-phosphatidylinositol 3-kinase-AKT-dependent manner, J Biol Chem, vol.289, pp.22785-22797, 2014. ,
Estogee eeepto ?? is a oel taaget of the Vo Hippel-Lindau protein and is responsible for the proliferation of VHL-deficient cells under hypoxic conditions, Cell Cycle, vol.11, pp.4462-4473 ,
Oxygen Sensing by Metazoans: The Central Role of the HIF Hydroxylase Pathway, Mol. Cell, vol.30, pp.393-402, 2008. ,
ER? and ER? expression in correlation with Ki67, Bcl-2 and Bak in primary tumors and lymph node metastases of breast cancer: The effect of pre-operative chemotherapy, Oncol Lett, vol.1, pp.1067-1071, 2010. ,
SWI/SNF regulates the cellular response to hypoxia, J Biol Chem, vol.284, pp.4123-4154, 2009. ,
Activation of the MKL1/actin signaling pathway induces hormonal escape in estrogen-responsive breast cancer cell lines, Mol Cell Endocrinol, vol.390, pp.34-44, 2014. ,
URL : https://hal.archives-ouvertes.fr/hal-01061363
Transfected MCF-7 cells as a model for breast-cancer progression, Breast Cancer Res Treat, vol.31, pp.153-165, 1994. ,
Update on estrogens and the skeleton, J. Clin. Endocrinol. Metab, vol.95, pp.3569-3577, 2010. ,
Anti-cancer effect of metformin by suppressing signaling pathway of HER2 and HER3 in tamoxifen-resistant breast cancer cells, Tumor Biol, vol.37, pp.5811-5819, 2016. ,
Acetylation of Estrogen Receptor ? by p300 at Lysines 266 and 268 Enhances the Deoxyribonucleic Acid Binding and Transactivation Activities of the Receptor, Mol Endocrinol, vol.20, pp.1479-1493, 2006. ,
Estrogen receptor alpha 46 is reduced in tamoxifen resistant breast cancer cells and re-expression inhibits cell proliferation and estrogen receptor alpha 66-regulated target gene transcription, Mol Cell Endocrinol, vol.323, pp.268-276, 2010. ,
Insulin-like growth factor-I receptor signaling in tamoxifen-resistant breast cancer: A supporting role to the epidermal growth factor receptor, Endocrinology, vol.146, pp.4609-4618, 2005. ,
The hypoxia associated factor (HAF) switches cells from HIF-1? to HIF-2? dependent signaling promoting stem cell characteristics, aggressive tumor growth and invasion.pdf, Cancer Res, vol.71, pp.4015-4042, 2011. ,
Passing the baton: The HIF switch, Trends Biochem. Sci, vol.37, pp.364-372, 2012. ,
Estrogen receptor gene disruption: molecular characterization and experimental and clinical phenotypes, Recent Prog Horm Res, vol.51, pp.158-159, 1996. ,
The hike oestogee eepto seeueeee: hoolog itherbA and the human oestrogen and glucocorticoid receptors, EMBO J, vol.5, pp.891-897 ,
Stroma-derived factor (SDF-1/CXCL12) and human tumor pathogenesis, Am J Physiol Cell Physiol, vol.292, pp.987-995, 2007. ,
The estrogen receptor binds tightly to its responsive element as a ligandinduced homodimer, Cell, vol.55, pp.145-156, 1988. ,
Functional domains of the human estrogen receptor, Cell, vol.51, pp.941-951, 1987. ,
Reconstruction of functionally normal and malignant human breast tissues in mice, Proc Natl Acad Sci U S A, vol.101, pp.4966-71, 2004. ,
Hypoxia reduces hormone responsiveness of human breast cancer cells, Jpn J Cancer Res, vol.92, pp.1093-1101, 2001. ,
Insulin/insulin-like growth factor-I and estrogen cooperate to stimulate cyclin E-Cdk2 activation and cell Cycle progression in MCF-7 breast cancer cells through differential regulation of cyclin E and p21(WAF1/Cip1), J Biol Chem, vol.276, pp.25823-25833, 2001. ,
Estrogen regulation of mammary gland development and breast cancer: amphiregulin takes center stage, Breast Cancer Res, vol.9, p.304, 2007. ,
Emerging Biological Principles of Metastasis, Cell, vol.168, pp.670-691, 2017. ,
The expression and prognostic value of ROCK I and ROCK II and their role in human breast cancer, Int J Oncol, vol.33, pp.585-593, 2008. ,
Estrogen acutely stimulates nitric oxide synthase activity in fetal pulmonary artery endothelium, Am J Physiol-Lung Cell Mol Physiol, vol.273, pp.119-126, 1997. ,
Skeletal muscle stem cells adopt a dormant cell state post mortem and retain regenerative capacity, Nat Commun, vol.3, p.903, 2012. ,
URL : https://hal.archives-ouvertes.fr/pasteur-00711881
Cancer stem cells and their microenvironment: Biology and therapeutic implications, Stem Cells Int, 2017. ,
Diverse signaling pathways modulate nuclear receptor recruitment of N-CoR and SMRT complexes, Proc Natl Acad Sci U S A, vol.95, pp.2920-2925, 1998. ,
Distinct structural transitions of chromatin topological domains correlate with coordinated hormone-induced gene regulation, Genes Dev, vol.28, pp.2151-2162, 2014. ,
Phosphorylation of the human estrogen receptor: Identification of hormone-regulated sites and examination of their influence on transcriptional activity, J Biol Chem, vol.269, pp.4458-4466, 1994. ,
Adipokines, inflammation, and visceral adiposity across the menopausal transition: A prospective study, J Clin Endocrinol Metab, vol.94, pp.1104-1110, 2009. ,
Unraveling the regulatory connections between two controllers of breast cancer cell fate, Nucleic Acids Res, vol.42, pp.6839-6849, 2014. ,
ER-alpha36, a novel variant of ER-alpha, is expressed in ER-positive and-negative human breast carcinomas, Anticancer Res, vol.28, pp.479-483, 2008. ,
Identification of constitutive and steroid-dependent transactivation domains in the mouse oestrogen receptor, J Steroid Biochem, vol.34, pp.33-39, 1989. ,
A bi-faceted role of estrogen receptor ? in breast cancer, Endocr. Relat. Cancer, vol.20, 2013. ,
, Wog J p Reeuies Its Histone Acetyltransferase Activity and SRC, issue.1
, Interaction Domain To Facilitate Thyroid Hormone Receptor Activation in Chromatin, Mol Cell Biol, vol.20, pp.2031-2042
Requirement of a myocardin-related transcription factor for development of mammary myoepithelial cells, Mol Cell Biol, vol.26, pp.5797-808, 2006. ,
Estrogen stimulation of cell migration involves multiple signaling pathway interactions, Endocrinology, vol.151, pp.5146-5156, 2010. ,
MRTF-A and STAT3 synergistically promote breast cancer cell migration, Cell Signal, vol.26, pp.2370-2380, 2014. ,
Aberrant luminal progenitors as the candidate target population for basal tumor development in BRCA1 mutation carriers, Nat Med, vol.15, pp.907-920, 2009. ,
ER-?36, a variant of ER-?, promotes tamoxifen agonist action in endometrial cancer cells via the MAPK/ERK and PI3K/Akt pathways, PLoS One, 2010. ,
Recruitment of Distinct Chromatin-modifying Complexes by Tamoxifencomplexed Estrogen Receptor at Natural Target Gene Promoters in Vivo, J Biol Chem, vol.279, pp.15050-15058, 2004. ,
Foxa1 is essential for mammary duct formation, Genesis, vol.54, pp.277-285, 2016. ,
Redued ell otilit aad eehaaed foal adhesio otat formation in cells from FAK-deficient mice, Nature, vol.377, pp.539-544 ,
PIK3CA mutations associated with gene signature of low mTORC1 signaling and better outcomes in estrogen receptor-positive breast cancer, Proc Natl Acad Sci U S A, vol.107, pp.10208-10221, 2010. ,
Estrogen and body weight regulation in women: the role of estrogen receptor alpha (ER-?) on adipocyte lipolysis, Acta Med Indones, vol.46, pp.333-341, 2014. ,
Scavenging of CXCL12 by CXCR7 promotes tumor growth and metastasis of CXCR4-positive breast cancer cells, Oncogene, vol.31, pp.4750-4758, 2012. ,
Functions of CXCL12 and CXCR4 in breast cancer, Cancer Lett, vol.238, pp.30-41, 2006. ,
Cistromics of hormone-dependent cancer, Endocr. Relat. Cancer, vol.16, pp.381-389, 2009. ,
The transcriptional coactivator FHL2 transmits Rho signals from the cell membrane into the nucleus, EMBO J, vol.21, pp.736-748, 2002. ,
Importance of PI3-kinase pathway in response/resistance to aromatase inhibitors, Steroids. pp, vol.750, p.752, 2011. ,
Nuclear and extranuclear pathway inputs in the regulation of global gene expression by estrogen receptors, Mol Endocrinol, vol.22, pp.2116-2143, 2008. ,
The Forkhead Box M1 Protein Regulates the Transcription of the Estrogen Receptor alpha in Breast Cancer Cells, J Biol Chem, vol.281, pp.25167-76, 2006. ,
Liganded and unliganded activation of estrogen receptor and hormone replacement therapies, Biochim Biophys Acta-Mol Basis Dis, vol.1812, 2011. ,
URL : https://hal.archives-ouvertes.fr/hal-00706529
PBX1 genomic pioneer function drives ER? signaling underlying progression in breast cancer, PLoS Genet, 2011. ,
FIH-1: A novel protein that interacts with HIF-1?? and VHL to mediate repression of HIF-1 transcriptional activity, Genes Dev, vol.15, pp.2675-2686, 2001. ,
Opportunities and strategies for breast cancer prevention through risk reduction, CA Cancer J Clin, vol.58, pp.347-371, 2008. ,
Histone Deacetylase 7 and FoxA1 in Estrogen-Mediated Repression of RPRM, Mol Cell Biol, vol.30, pp.399-412, 2010. ,
Metastatic Latency and Immune Evasion through Autocrine Inhibition of WNT, Cell, vol.165, pp.45-60, 2016. ,
Paracrine signaling through the epithelial estrogen receptor alpha is required for proliferation and morphogenesis in the mammary gland, Proc Natl Acad Sci U S A, vol.103, pp.2196-2201, 2006. ,
URL : https://hal.archives-ouvertes.fr/hal-00188034
Membrane association of estrogen receptor ? and ? influences 17?estradiol-mediated cancer cell proliferation, Steroids, vol.73, pp.853-858, 2008. ,
S-palmitoylation modulates estrogen receptor ? localization and functions, Steroids, vol.71, pp.298-303, 2006. ,
Genome-wide analysis of aromatase inhibitor-resistant, tamoxifen-resistant, and long-term estrogen-deprived cells reveals a role for estrogen receptor, Cancer Res, vol.68, pp.4910-4918, 2008. ,
, TGFbeta in Cancer. Cell, vol.134, pp.215-245, 2008.
Metastatic colonization by circulating tumour cells, Nature, vol.529, pp.298-306, 2016. ,
HIF induces human embryonic stem cell markers in cancer cells, Cancer Res, vol.71, pp.4640-4652, 2011. ,
The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis, Nature, vol.399, pp.271-275, 1999. ,
Determinants of coactivator LXXLL motif specificity in nuclear receptor transcriptional activation, Genes Dev, vol.12, pp.3357-3368, 1998. ,
Katzeeelleeogee BS AAalsis of esttogee eepto transcriptional enhancement by a nuclear hormone receptor coactivator, Proc Natl Acad Sci U S A, vol.93, pp.10069-73 ,
The complete family of epidermal growth factor receptors and their ligands are co-ordinately expressed in breast cancer, Breast Cancer Res Treat, vol.122, pp.105-110, 2010. ,
URL : https://hal.archives-ouvertes.fr/hal-00535394
Myocardin-related transcription factors and SRF are required for cytoskeletal dynamics and experimental metastasis, Nat Cell Biol, vol.11, pp.257-268, 2009. ,
Glycogen synthase kinase-3 interacts with and phosphorylates estrogen receptor alpha and is involved in the regulation of receptor activity, J Biol Chem, vol.280, pp.33006-33014, 2005. ,
The relative contribution exerted by AF-1 and AF-2 transactivation functions in estrogen receptor ? transcriptional activity depends upon the differentiation stage of the cell, J Biol Chem, vol.279, pp.26184-26191, 2004. ,
Synergism Between ER Transactivation Function 1 (AF-1) and AF-2 Mediated by Steroid Receptor Coactivator Protein-1: Requirement for the AF-1-Helical Core and for a Direct Interaction Between the N-and C-Terminal Domains, Mol Endocrinol, vol.15, pp.1953-1970, 2001. ,
Estrogen receptor-? directs ordered, cyclical, and combinatorial recruitment of cofactors on a natural target promoter, Cell, vol.115, pp.751-763, 2003. ,
A dynamic structural model for estrogen receptor-? activation by ligands, emphasizing the role of interactions between distant A and E domains, Mol Cell, vol.10, pp.1019-1032, 2002. ,
Characterization of the amino-terminal transcriptional activation function of the human estrogen receptor in animal and yeast cells, J Biol Chem, vol.270, pp.9535-9542, 1995. ,
Promoter specificity of the two transcriptional activation functions of the human oestrogen receptor in yeast, Nucleic Acids Res, vol.20, pp.2813-2817, 1992. ,
Epithelial-mesenchymal transition in cancer: Parallels between normal development and tumor progression, J. Mammary Gland Biol. Neoplasia, vol.15, pp.117-134, 2010. ,
Tyrosine kinase/p21ras/MAP-kinase pathway activation by estradiol-receptor complex in MCF-7 cells, EMBO J, vol.15, pp.1292-1300, 1996. ,
Immediate and transient stimulation of protein tyrosine phosphorylation by estradiol in MCF-7 cells, Oncogene, vol.8, pp.2183-2191, 1993. ,
Calmodulin-stimulated phosphorylation of 17?-estradiol receptor on tyrosine, 1984. ,
Estradiol receptor: phosphorylation on tyrosine in uterus and interaction with anti-phosphotyrosine antibody, EMBO J, vol.5, pp.2867-2872, 1986. ,
Loss of Phosphatase and tensin homologue deleted on chromosome 10 engages ErbB3 and insulin-like growth factor-I receptor signaling to promote antiestrogen resistance in breast cancer, Cancer Res, vol.69, pp.4192-4201, 2009. ,
Hypoxia-inducing factors as master regulators of stemness properties and altered metabolism of cancer-and metastasis-initiating cells, J Cell Mol Med, vol.17, pp.30-54, 2013. ,
Actin dynamics control SRF activity by regulation of its coactivator MAL, Cell, vol.113, pp.329-342, 2003. ,
Upstream determinants of estrogen receptor-? regulation of metastatic tumor antigen 3 pathway, J Biol Chem, vol.279, pp.32709-32715, 2004. ,
Hypoxia and radiotherapy: Opportunities for improved outcomes in cancer treatment, Cancer Metastasis Rev, vol.26, pp.241-248, 2007. ,
An oestrogen-receptor-agr-bound human chromatin interactome, Nature, 2009. ,
Genome-wide association of hypoxia-inducible factor (HIF)-1a and HIF-2a DNA binding with expression profiling of hypoxia-inducible transcripts, J Biol Chem, vol.284, pp.16767-16775, 2009. ,
BRCA1 basal-like breast cancers originate from luminal epithelial progenitors and not from basal stem cells, Cell Stem Cell, vol.7, pp.403-417, 2010. ,
The carboxy-terminal F domain of the human estrogen receptor: role in the transcriptional activity of the receptor and the effectiveness of antiestrogens as estrogen antagonists, Mol Endocrinol, vol.9, pp.814-839, 1995. ,
Metastasis-associated protein 1 enhances angiogenesis by stabilization of HIF-1?, Oncol Rep, vol.16, pp.929-935, 2006. ,
The nuclear receptor ligand-binding domain: structure and function, Curr Opin Cell Biol, vol.10, pp.384-391, 1998. ,
FM19G11, a new hypoxiainducible factor (HIF) modulator, affects stem cell differentiation status, J Biol Chem, vol.285, pp.1333-1342, 2010. ,
Hypoxia inducible factor expression in intrahepatic cholangiocarcinoma, Hepatogastroenterology, vol.58, pp.1439-1444, 2011. ,
ER beta: identification and characterization of a novel human estrogen receptor, FEBS Lett, vol.392, issue.96, p.782, 1996. ,
Regulation of hypoxia-inducible factor-1alpha protein level during hypoxic conditions by the phosphatidylinositol 3-kinase/Akt/glycogen synthase kinase 3beta pathway in HepG2 cells, J Biol Chem, vol.278, pp.31277-85, 2003. ,
Altered expression of estrogen receptor coregulators during human breast tumorigenesis, Cancer Res, vol.60, pp.6266-71, 2000. ,
The role of hypoxia in cancer progression, angiogenesis, metastasis, and resistance to therapy, Hypoxia, vol.83, 2015. ,
Inverse relationship between ER-beta and SRC-1 predicts outcome in endocrine-resistant breast cancer, Br J Cancer, vol.91, pp.1687-1693, 2004. ,
Identification of MAPK phosphorylation sites and their role in the localization and activity of hypoxia-inducible factor-1?, J Biol Chem, vol.281, pp.33095-33106, 2006. ,
Med1 plays a critical role in the development of tamoxifen resistance, Carcinogenesis, vol.33, pp.918-930, 2012. ,
Estrogens and atherosclerosis, Annu Rev Pharmacol Toxicol, vol.37, pp.477-515, 1997. ,
Growth factor signalling in endocrine and antigrowth factor resistant breast cancer, Rev. Endocr. Metab. Disord, vol.8, pp.241-253, 2007. ,
DOI : 10.1007/s11154-007-9033-5
Immunohistochemical and clinical characterization of the basal-like subtype of invasive breast carcinoma, Clin Cancer Res, vol.10, pp.5367-5374, 2004. ,
Europe PMC Funders Group Landscape of somatic mutations in 560 breast cancer whole genome sequences, vol.534, pp.47-54, 2016. ,
Crosstalk between CTC, Immune System and Hypoxic Tumor Microenvironment, Cancer Microenviron, vol.7, pp.153-160, 2014. ,
DOI : 10.1007/s12307-014-0157-3
URL : http://europepmc.org/articles/pmc4275540?pdf=render
Linking actin dynamics and gene transcription to drive cellular motile functions, Nat Rev Mol Cell Biol, vol.11, pp.353-65, 2010. ,
DOI : 10.1038/nrm2890
URL : http://europepmc.org/articles/pmc3073350?pdf=render
Gene amplification of ESR1 in breast cancers-fact or fiction? A fluorescence in situ hybridization and multiplex ligation-dependent probe amplification study, J Pathol, vol.227, pp.8-16, 2012. ,
Attacking canceees AAhilles heel: aatagois of aati-apoptotic BCL-2 family members, FEBS J, pp.2661-2675, 2016. ,
Rho GTPases modulate malignant transformation of tumor cells, Small GTPases, vol.5, p.983867, 2014. ,
Role of the estrogen receptor coactivator AIB1 (SRC-3) and HER-2/neu in tamoxifen resistance in breast cancer, J Natl Cancer Inst, vol.95, pp.353-61, 2003. ,
Estrogen receptor: Current understanding of its activation and modulation, Clin Cancer Res, vol.7, pp.4338-4342, 2001. ,
Breast cancer cells produce tenascin C as a metastatic niche component to colonize the lungs, Nat Med, vol.17, pp.867-74, 2011. ,
Estrogen represses gene expression through reconfiguring chromatin structures, Nucleic Acids Res, vol.41, pp.8061-8071, 2013. ,
The myc oncogene: Marvelously complex, Adv. Cancer Res, vol.84, pp.81-154, 2002. ,
THE METABOLISM OF TUMORS IN THE BODY, The Journal of General Physiology. Biochem Z Biochem Z Biochem Z. Biol Chem, vol.309, pp.397-519, 1923. ,
Genome-independent hypoxic repression of estrogen receptor alpha in breast cancer cells. 1-16, 2017. ,
Ligand-selective interdomain conformations of estrogen receptor-alpha, Mol Endocrinol, vol.21, pp.49-61, 2007. ,
TGF? Primes Breast Tumors for Lung Metastasis Seeding through Angiopoietin-like 4, Cell, vol.133, pp.66-77, 2008. ,
Mammary epithelial cell interactions with fibronectin stimulate epithelial-mesenchymal transition, Oncogene, vol.33, pp.1649-57, 2014. ,
Hypoxia increases androgen receptor activity in prostate cancer cells, Cancer Res, vol.66, pp.5121-5129, 2006. ,
Estradiol, TGF-??1 and hypoxia promote breast cancer stemness and EMT-mediated breast cancer migration, Oncol Lett, vol.11, pp.1895-1902, 2016. ,
Effects of inhibiting the proteasomal degradation of estrogen receptor alpha on estrogen receptor alpha activation under hypoxic conditions, Biol Pharm Bull, vol.32, pp.2057-60, 2009. ,
Nature of Functional Estrogen Receptors at the Plasma Membrane, Mol Endocrinol, vol.20, pp.1996-2009, 2006. ,
Stromal estrogen receptor-? promotes tumor growth by normalizing an increased angiogenesis, Cancer Res, vol.72, pp.3010-3019, 2012. ,
AP-2 transcription factors in the regulation of ERBB2 gene transcription by oestrogen, Oncogene, vol.19, pp.280-288, 2000. ,
The role of integrin-linked kinase (ILK) in cancer progression, Cancer Metastasis Rev, vol.22, pp.375-384, 2003. ,
Hypoxia promotes glycogen accumulation through hypoxia inducible factor (HIF)-mediated induction of glycogen synthase 1, PLoS One, 2010. ,
Estrogen receptor domains E and F: role in dimerization and interaction with coactivator RIP-140, Mol Endocrinol, vol.13, pp.286-296, 1999. ,
Mediator Architecture and RNA Polymerase II Interaction, J Mol Biol, vol.428, pp.2569-2574, 2016. ,
DOI : 10.1016/j.jmb.2016.01.028
Unliganded and liganded estrogen receptors protect against cancer invasion via different mechanisms, Mol Endocrinol, vol.14, pp.999-1009, 2000. ,
Expression of alternatively spliced estrogen receptor alpha mRNAs is increased in breast cancer tissues, J Steroid Biochem Mol Biol, vol.78, pp.118-120, 2001. ,
Targeting PI3K/Akt/mTOR Signaling in Cancer, Front Oncol, vol.4, p.64, 2014. ,
Mutant Actins Demonstrate a Role for Unpolymerized Actin in Control of Transcription by Serum Response Factor, Mol Biol Cell, vol.13, pp.2001-2015, 2002. ,
Activation of rapid oestrogen signalling in aggressive human breast cancers, EMBO Mol Med, vol.4, pp.1200-1213, 2012. ,
Molecular characterization of basal-like and non-basal-like triple-negative breast cancer, Oncologist, vol.18, pp.123-156, 2013. ,
Phenotypic and molecular characterization of the claudinlow intrinsic subtype of breast cancer, Breast Cancer Res, vol.12, p.68, 2010. ,
Deconstructing the molecular portraits of breast cancer, Mol. Oncol, vol.5, pp.5-23, 2011. ,
Mammary stem cells have myoepithelial cell properties, Nat Cell Biol, vol.16, pp.942-950, 2014. ,
Steroid receptor interactions with heat shock protein and immunophilin chaperones, Endocr Rev, vol.18, pp.306-360, 1997. ,
Novel CARM1 Interacting Protein, DZIP3, is a Transcriptional Coactivator of Estrogen Receptor alpha, Mol Endocrinol me, pp.2015-1083, 2015. ,
Direct interaction between estrogen receptor alpha and NF-kappaB in the nucleus of living cells, Mol Cell Endocrinol, vol.273, pp.42-50, 2007. ,
NF-kappa B links oestrogen receptor signalling and EMT, Nat Cell Biol, vol.9, pp.361-363, 2007. ,
Estrogenic regulation of the GnRH neuron, Front. Endocrinol. (Lausanne), vol.3, 2012. ,
Oncogenic potential of the nuclear receptor coregulator proline-, glutamic acid-, leucine-rich protein 1/modulator of the nongenomic actions of the estrogen receptor, Cancer Res, vol.67, pp.5505-5512, 2007. ,
Overcoming disappointing results with antiangiogenic therapy by targeting hypoxia, Nat Rev Clin Oncol, vol.9, pp.1-14, 2012. ,
Identification of a structural determinant necessary for the localization and function of estrogen receptor alpha at the plasma membrane, Mol Cell Biol, vol.23, pp.1633-1679, 2003. ,
ERs associate with and regulate the production of caveolin: implications for signaling and cellular actions, Mol Endocrinol, vol.16, pp.100-115, 2002. ,
ER?1: characterization, prognosis, and evaluation of treatment strategies in ER?-positive and-negative breast cancer, BMC Cancer, vol.14, p.749, 2014. ,
A Transmembrane Intracellular Estrogen Receptor Mediates Rapid Cell Signaling, Science (80-), vol.307, pp.1625-1630, 2005. ,
Hypoxia-inducible factor-1-dependent mechanisms of vascularization and vascular remodelling, Cardiovasc. Res, vol.86, pp.236-242, 2010. ,
Activation of mitogen-and stress-activated kinase 1 is required for proliferation of breast cancer cells in response to estrogens or progestins, Oncogene, vol.33, pp.1570-80, 2014. ,
Recurrent and functional regulatory mutations in breast cancer, Nature, vol.547, pp.55-60, 2017. ,
Activating ESR1 mutations in hormone-resistant metastatic breast cancer, Nat Genet, vol.45, pp.1446-51, 2013. ,
Estrogen receptor mediated inhibition of cancer cell invasion and motility: an overview, J Steroid Biochem Mol Biol, vol.65, pp.163-171, 1998. ,
Potentiation of human estrogen receptor ? transcriptional activation through phosphorylation of serines 104 and 106 by the cyclin A-CDK2 complex, J Biol Chem, vol.274, pp.22296-22302, 1999. ,
Decreased expression of estrogen receptor beta protein in proliferative preinvasive mammary tumors, Cancer Res, vol.61, pp.2537-2541, 2001. ,
The role of estrogen receptors in the control of energy and glucose homeostasis, Steroids, vol.73, pp.874-879, 2008. ,
Differential oestrogen receptor binding is associated with clinical outcome in breast cancer, Nature, vol.481, p.389, 2012. ,
Differentiation of the mammary gland and susceptibility to carcinogenesis, Breast Cancer Res. Treat, vol.2, pp.5-73, 1982. ,
Hypoxia-inducible factor 1 alpha represses the transcription of the estrogen receptor alpha gene in human breast cancer cells, Biochem Biophys Res Commun, vol.407, pp.831-836, 2011. ,
Transcriptional activation of genes by 17 beta-estradiol through estrogen receptor-Sp1 interactions, Vitam Horm, vol.62, pp.62006-62011, 2001. ,
Role of Estrogen Receptor Signaling in Breast Cancer Metastasis, Int J Breast Cancer, vol.2012, pp.1-8, 2012. ,
, CXCR7 impact on CXCL12 biology and disease, vol.19, pp.12-22, 2013.
MAPK signaling up-regulates the activity of hypoxia-inducible factors by its effects on p300, J Biol Chem, vol.278, pp.14013-14019, 2003. ,
Long-term estradiol deprivation in breast cancer cells upregulates growth factor signaling and enhances estrogen sensitivity, Endocrine-Related Cancer, 2005. ,
Chromosome conformation capture technologies and their impact in understanding genome function, Chromosoma, vol.126, pp.33-44, 2017. ,
URL : https://hal.archives-ouvertes.fr/hal-01506418
Estrogen regulation of anti-apoptotic Bcl-2 family member Mcl-1 expression in breast cancer cells, PLoS One, 2014. ,
Megakaryoblastic leukemia protein-1 (MKL1): Increasing evidence for an involvement in cancer progression and metastasis, Int. J. Biochem. Cell Biol, vol.42, pp.1911-1914, 2010. ,
Hypoxia-Inducible Factors: Master Regulators of Cancer Progression, Trends in Cancer, vol.2, pp.758-770, 2016. ,
High-resolution genome-wide mapping of HIFbinding sites by ChIP-seq, Blood, 2011. ,
Solution structure of the DNA-binding domain of the oestrogen receptor, Nature, vol.348, pp.458-61, 1990. ,
Defining the role of hypoxia-inducible factor 1 in cancer biology and therapeutics, Oncogene, vol.29, pp.625-659, 2010. ,
Hypoxia-inducible factors in physiology and medicine, Cell, vol.148, pp.399-408, 2012. ,
HIF-1: upstream and downstream of cancer metabolism, Curr. Opin. Genet. Dev, vol.20, pp.51-56, 2010. ,
The hypoxic tumor microenvironment: A driving force for breast cancer progression, Biochim. Biophys. Acta-Mol. Cell Res, vol.1863, pp.382-391, 2016. ,
Sumoylation of the estrogen receptor alpha hinge region regulates its transcriptional activity, Mol Endocrinol, vol.19, pp.2671-2684, 2005. ,
A nuclear MAL-function links Rho to SRF, Mol. Cell, vol.11, pp.1121-1123, 2003. ,
DOI : 10.1016/s1097-2765(03)00189-8
URL : https://doi.org/10.1016/s1097-2765(03)00189-8
Mutation of serines 104, 106, and 118 inhibits dimerization of the human estrogen receptor in yeast, Endocr Res, vol.29, pp.237-55, 2003. ,
Soyfood intake during adolescence and subsequent risk of breast cancer among Chinese women, Cancer Epidemiol Biomarkers Prev, vol.10, pp.483-488, 2001. ,
Breast cancer biological subtypes and protein expression predict for the preferential distant metastasis sites: a nationwide cohort study, Breast Cancer Res, vol.13, p.87, 2011. ,
Rating the risk factors for breast cancer, Ann Surg, vol.237, pp.474-82, 2003. ,
DOI : 10.1097/01.sla.0000059969.64262.87
URL : https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1514477/pdf
The origin of breast tumor heterogeneity, Oncogene, vol.34, pp.5309-5316, 2015. ,
CD24 staining of mouse mammary gland cells defines luminal epithelial, myoepithelial/basal and non-epithelial cells, Breast Cancer Res, vol.8, 2005. ,
Coaatiato aad oeppesso egulatio of the agonist/antagonist activity of the mixed antiestrogen, 4-hydroxytamoxifen, Mol Endocrinol, vol.11, pp.657-666 ,
The MRTF-A/B function as oncogenes in pancreatic cancer, Oncol Rep, vol.35, pp.127-138, 2016. ,
Signal-regulated activation of serum response factor is mediated by changes in actin dynamics, Cell, vol.98, pp.81011-81020, 1999. ,
Biology of hypoxia, Semin Nucl Med, vol.45, pp.101-109, 2015. ,
Chromatin signatures of active enhancers, Nucleus, vol.3, pp.126-157, 2012. ,
URL : https://hal.archives-ouvertes.fr/hal-01614959
Activation of AKT by hypoxia: a potential target for hypoxic tumors of the head and neck, BMC Cancer, vol.12, p.463, 2012. ,
A meta-analysis of the effect of estrogen replacement therapy on the risk of breast cancer, J Am Med Assoc, vol.265, pp.1985-1990, 1991. ,
Genome-Wide Analysis of Estrogen Receptor DNA Binding and Tethering Mechanisms Identifies Runx1 as a Novel Tethering Factor in Receptor-Mediated Transcriptional Activation, Mol Cell Biol, vol.30, pp.3943-3955, 2010. ,
The Estrogen-Regulated Transcription Factor PITX1 Coordinates Gene-Specific Regulation by Estrogen Receptor-Alpha in Breast Cancer Cells, Mol Endocrinol, vol.25, pp.1699-1709, 2011. ,
Non-canonical HIF-2? function drives autonomous breast cancer cell growth via an AREG-EGFR/ErbB4 autocrine loop, Oncogene, vol.31, pp.2283-2297, 2011. ,
Hypoxia Induces Proteasome-Dependent Degradation of Estrogen Receptor alpha in ZR-75 Breast Cancer Cells, Mol Endocrinol, vol.16, pp.2231-2242, 2002. ,
Estrogen-occupied estrogen receptor represses cyclin G2 gene expression and recruits a repressor complex at the cyclin G2 promoter, J Biol Chem, vol.281, pp.16272-16278, 2006. ,
Estrogen receptor beta inhibits 17beta-estradiol-stimulated proliferation of the breast cancer cell line T47D, Proc Natl Acad Sci U S A, vol.101, pp.1566-71, 2004. ,
Regulation of estrogen receptor alpha by the SET7 lysine methyltransferase, Mol Cell, vol.30, pp.336-383, 2008. ,
Function of the IGF-I receptor in breast cancer, J. Mammary Gland Biol. Neoplasia, vol.5, pp.95-105, 2000. ,
The multiple roles of transcription/repair factor TFIIH, Trends Biochem. Sci, vol.21, pp.346-350, 1996. ,
monophosphate in rat uterus: acute elevation by estrogen, Proc Natl Acad Sci U S A, vol.58, pp.1711-1719 ,
AP-2? regulates oestrogen receptor-mediated long-range chromatin interaction and gene transcription, EMBO J, vol.30, pp.2569-81, 2011. ,
ER and PR signaling nodes during mammary gland development, Breast Cancer Res, vol.14, p.210, 2012. ,
Core epithelial-to-mesenchymal transition interactome gene-expression signature is associated with claudin-low and metaplastic breast cancer subtypes, Proc Natl Acad Sci U S A, vol.107, pp.15449-15454, 2010. ,
Estrogen receptor mutations and functional consequences for breast cancer, Trends Endocrinol Metab, vol.26, pp.467-476, 2015. ,
Endogenous estrogen and postmenopausal breast cancer: A quantitative review, Cancer Causes Control, vol.8, pp.922-928, 1997. ,
Transcriptional activation: A complex puzzle with few easy pieces, Cell, vol.77, pp.5-8, 1994. ,
BRCA1 and GATA3 corepress FOXC1 to inhibit the pathogenesis of basal-like breast cancers, Oncogene, vol.31, pp.3667-3678, 2012. ,
Minireview: Basal-like breast cancer: from molecular profiles to targeted therapies, Mol Endocrinol, vol.25, pp.199-211, 2011. ,
Cancer etiology. Variation in cancer risk among tissues can be explained by the number of stem cell divisions, Science, vol.347, pp.78-81, 2015. ,
Phosphorylation and activation of RhoA by ERK in response to epidermal growth factor stimulation, PLoS One, 2016. ,
ESR1 ligand-binding domain mutations in hormone-resistant breast cancer, Nat Genet, vol.45, pp.1439-1484, 2013. ,
Divergent regulation of ER and Kiss genes by 17?-estradiol in hypothalamic ARC versus AVPV models, Mol Endocrinol, vol.30, 2016. ,
Meta-analysis of soy intake and breast cancer risk, J Natl Cancer Inst, vol.98, pp.459-471, 2006. ,
Endocrine treatment in breast cancer: Cure, resistance and beyond, Cancer Treat. Rev, vol.50, pp.68-81, 2016. ,
Epigenetic regulation of hypoxia-responsive gene expression: Focusing on chromatin and DNA modifications, Int. J. Cancer, vol.134, pp.249-256, 2014. ,
Estrogen induces stromal cell-derived factor 1 (SDF1/CXCL12) production in human endometrial stromal cells: A possible role of endometrial epithelial cell growth, Fertil Steril, vol.95, pp.444-447, 2011. ,
Prolonged hypoxia differentially regulates hypoxiainducible factor (HIF)-1alpha and HIF-2alpha expression in lung epithelial cells: implication of natural antisense HIF-1alpha, J Biol Chem, vol.279, pp.14871-14879, 2004. ,
Estrogen regulation of the insulin-like growth factor I gene transcription involves an AP-1 enhancer, J Biol Chem, vol.269, pp.16433-16442, 1994. ,
Understanding the Warburg effect: The metabolic Requiremetns of cell proliferation, Science (80), vol.324, pp.1029-1033, 2009. ,
Nuclear actin regulates dynamic subcellular localization and activity of the SRF cofactor MAL, Science, vol.316, pp.1749-52, 2007. ,
The current state of breast cancer classification, Ann Oncol, 2012. ,
Induction of Progesterone Target Genes Requires Activation of Erk and Msk Kinases and Phosphorylation of Histone H3, Mol Cell, vol.24, pp.367-381, 2006. ,
Epithelial-Mesenchymal Transition (EMT) and Regulation of EMT Factors by Steroid Nuclear Receptors in Breast Cancer: A Review and in Silico Investigation, J Clin Med, vol.5, p.11, 2016. ,
Sequence homologies in the region preceding the transcription initiation site of the liver estrogen-responsive vitellogenin and apo-VLDLII genes, Nucleic Acids Res, vol.12, pp.8611-8626, 1984. ,
A coregulatory role for the TRAP-Mediator complex in androgen receptor-mediated gene expression, J Biol Chem, vol.277, pp.42852-42858, 2002. ,
Identification and testing of a gene expression signature of invasive carcinoma cells within primary mammary tumors, Cancer Res, vol.64, pp.8585-8594, 2004. ,
Oestrogen signalling inhibits invasive phenotype by repressing RelB and its target BCL2, Nat Cell Biol, vol.9, pp.470-478, 2007. ,
URL : https://hal.archives-ouvertes.fr/inserm-00145547
Injuring of Respiration the Origin of Cancer Cells, Science (80-), vol.123, pp.309-323, 1956. ,
Steroid receptor phosphorylation: Assigning function to site-specific phosphorylation, BioFactors, vol.35, pp.528-536, 2009. ,
DOI : 10.1002/biof.66
URL : http://europepmc.org/articles/pmc2788675?pdf=render
Differential Recruitment of the Mammalian Mediator Subunit TRAP220 by Estrogen Receptors ER?? and ER?, J Biol Chem, vol.276, pp.23397-23404, 2001. ,
Inhibition of c-myc Expression by Phosphorothioate Antisense Oligonucleotide Identifies a Critical Role for c-myc in the Growth of Human Breast Cancer, Cancer Res, vol.51, pp.3996-4000, 1991. ,
Constitutively active human estrogen receptors containing amino acid substitutions for tyrosine 537 in the receptor protein, Mol Endocrinol, vol.10, pp.1388-98, 1996. ,
Ligand-independent activation of the oestrogen receptor by mutation of a conserved tyrosine, EMBO J, vol.16, pp.1427-1435, 1997. ,
Association of breast cancer DNA methylation profiles with hormone receptor status and response to tamoxifen, Cancer Res, vol.64, pp.3807-3813, 2004. ,
A genome-wide study of the repressive effects of estrogen receptor beta on estrogen receptor alpha signaling in breast cancer cells, Oncogene, vol.27, pp.1019-1032, 2008. ,
The histone demethylase KDM4B regulates peritoneal seeding of ovarian cancer, Oncogene, vol.36, pp.2565-2576, 2017. ,
Randomized phase III placebo-controlled trial of letrozole plus oral temsirolimus as first-line endocrine therapy in postmenopausal women with locally advanced or metastatic breast cancer, J Clin Oncol, vol.31, pp.195-202, 2013. ,
Adolescent and adult soy intake and risk of breast cancer in AsianAmericans, Carcinogenesis, vol.23, pp.1491-1496, 2002. ,
Hypoxia drives breast tumor malignancy through a TET-TNF?p38-MAPK signaling axis, Cancer Res, vol.75, pp.3912-3924, 2015. ,
Hypoxia regulates stemness of breast cancer MDA-MB-231 cells, Med Oncol, 2016. ,
MKL1 links epigenetic activation of MMP2 to ovarian cancer cell migration and invasion, Biochem Biophys Res Commun, 2017. ,
Molecular mechanisms of estrogen carcinogenesis, Annu Rev Pharmacol Toxicol, vol.36, pp.203-232, 1996. ,
Estrogen receptor-? directly regulates the hypoxia-inducible factor 1 pathway associated with antiestrogen response in breast cancer, Proc Natl Acad Sci U S A, vol.112, pp.15172-15179, 2015. ,
The histone demethylase JMJD2B is regulated by estrogen receptor ? and hypoxia, and is a key mediator of estrogen induced growth, Cancer Res, vol.70, pp.6456-6466, 2010. ,
Distinct EMT programs control normal mammary stem cells and tumour-initiating cells, Nature, vol.525, pp.256-260, 2015. ,
ERalpha signaling through slug regulates E-cadherin and EMT, Oncogene, vol.29, pp.1451-1462, 2010. ,
Estrogen and hypoxia regulate estrogen receptor alpha in a synergistic manner, Biochem Biophys Res Commun, vol.378, pp.842-846, 2009. ,
The effects of estrogen-responsive element-and ligand-induced structural changes on the recruitment of cofactors and transcriptional responses by ER alpha and ER beta, Mol Endocrinol, vol.16, pp.674-693, 2002. ,
Mediator MED23 plays opposing roles in directing smooth muscle cell and adipocyte differentiation, Genes Dev, vol.26, pp.2192-2205, 2012. ,
Cooperation of proto-signals for nuclear accumulation of estrogen and progesterone receptors, EMBO J, vol.11, pp.3681-94, 1992. ,
Induction of cell proliferation and survival genes by estradiolrepressed microRNAs in breast cancer cells, BMC Cancer, vol.12, p.29, 2012. ,
Hypoxia-inducible factor 1 and VEGF upregulate CXCR4 in glioblastoma: implications for angiogenesis and glioma cell invasion, Lab Investig, vol.86, pp.1221-1232, 2006. ,
Arginine and glutamate-rich 1 (ARGLU1) interacts with mediator subunit 1 (MED1) and is required for estrogen receptor-mediated gene transcription and breast cancer cell growth, J Biol Chem, vol.286, pp.17746-17754, 2011. ,
Silencing MED1 Sensitizes Breast Cancer Cells to Pure AntiEstrogen Fulvestrant In Vitro and In Vivo, PLoS One, 2013. ,
An estrogen receptor mutant with strong hormoneindependent activity from a metastatic breast cancer, Cancer Res, vol.57, pp.1244-1249, 1997. ,
Alohol osuuptio aad east aae isk i the Woeees Health Study, Am J Epidemiol, vol.165, pp.667-76 ,
MED1/TRAP220 exists predominantly in a TRAP/Mediator subpopulation enriched in RNA polymerase II and is required for ER-mediated transcription, Mol Cell, vol.19, pp.89-100, 2005. ,
Estrogen receptor-alpha variant, ER-alpha36, is involved in tamoxifen resistance and estrogen hypersensitivity, Endocrinology, vol.154, pp.1990-1998, 2013. ,
DOI : 10.1210/en.2013-1116
URL : https://academic.oup.com/endo/article-pdf/154/6/1990/8979632/endo1990.pdf
Elevated insulin-like growth factor 1 receptor signaling induces antiestrogen resistance through the MAPK/ERK and PI3K/Akt signaling routes, Breast Cancer Res, vol.13, p.52, 2011. ,
DOI : 10.1186/bcr2883
URL : https://breast-cancer-research.biomedcentral.com/track/pdf/10.1186/bcr2883
Families of nuclear receptors in vertebrate models: characteristic and comparative toxicological perspective, Sci Rep, vol.5, p.8554, 2015. ,
Prognostic significance of HIF-1? expression in hepatocellular carcinoma: a meta-analysis, PLoS One, vol.8, p.65753, 2013. ,
ER?1 inhibits the migration and invasion of breast cancer cells through upregulation of E-cadherin in a Id1-dependent manner, Biochem Biophys Res Commun, vol.457, pp.141-147, 2015. ,
Loss of PTEN facilitates HIF-1-mediated gene expression, Genes Dev, vol.14, pp.391-396, 2000. ,
Oestrogen receptor-co-factor-chromatin specificity in the transcriptional regulation of breast cancer, EMBO J, vol.30, pp.4764-4776, 2011. ,