Skip to Main content Skip to Navigation
Theses

Analyse multi-niveaux en biologie systémique computationnelle : le cas des cellules HeLa sous traitement apoptotique

Abstract : This thesis examines a new way to study the impact of a given pathway on the dynamics of a tissue through Multi-Level Analysis. The analysis is split in two main parts: The first part considers models describing the pathway at the cellular level. Using these models, one can compute in a tractable manner the dynamics of a group of cells, representing it by a multivariate distribution over concentrations of key molecules. % of the distribution of the states of this pathway through groups of cells. The second part proposes a 3d model of tissular growth that considers the population of cell as a set of subpopulations, partitionned such as each subpopulation shares the same external conditions. For each subpopulation, the tractable model presented in the first part can be used. This thesis focuses mainly on the first part, whereas a chapter covers a draft of a model for the second part.
Document type :
Theses
Complete list of metadatas

Cited literature [54 references]  Display  Hide  Download

https://tel.archives-ouvertes.fr/tel-01935280
Contributor : Abes Star :  Contact
Submitted on : Monday, November 26, 2018 - 3:42:09 PM
Last modification on : Wednesday, September 9, 2020 - 3:50:24 AM
Long-term archiving on: : Wednesday, February 27, 2019 - 2:52:26 PM

File

PICHENE_Matthieu.pdf
Version validated by the jury (STAR)

Identifiers

  • HAL Id : tel-01935280, version 1

Citation

Matthieu Pichené. Analyse multi-niveaux en biologie systémique computationnelle : le cas des cellules HeLa sous traitement apoptotique. Bio-informatique [q-bio.QM]. Université Rennes 1, 2018. Français. ⟨NNT : 2018REN1S026⟩. ⟨tel-01935280⟩

Share

Metrics

Record views

134

Files downloads

92