M. Chatzifrangkeskou, C. L. Dour, W. Wu, J. P. Morrow, L. C. Joseph et al., Human Molecular Genetics, 2016.

M. Chatzifrangkeskou, D. Yadin, Y. Tanguy, T. Marais, S. Chardonnet et al.,

I. Agarkova and J. C. Perriard, The M-band: an elastic web that crosslinks thick filaments in the center of the sarcomere, Trends Cell Biol, vol.15, pp.477-485, 2005.

B. J. Agnew, L. S. Minamide, and J. R. Bamburg, Reactivation of phosphorylated actin depolymerizing factor and identification of the regulatory site, J. Biol. Chem, vol.270, pp.17582-17587, 1995.

P. B. Agrawal, R. S. Greenleaf, K. K. Tomczak, V. L. Lehtokari, C. Wallgreen-pettersson et al., Nemaline myopathy with minocores caused by mutation of the CFL2 gene encoding the skeletal muscle actin-binding protein, cofilin-2, Hum. Mol. Genet, vol.80, pp.162-167, 2007.

R. Ajima, J. A. Bisson, J. C. Helt, M. A. Nakaya, R. Habas et al., DAAM1 and DAAM2 are co-required for myocardial maturation and sarcomere assembly, Dev. Biol, vol.408, pp.126-139, 2015.

A. Arber, F. A. Barbayannis, H. Hanser, C. Schneider, C. A. Stanyon et al., Regulation of actin dynamics through phosphorylation of cofilin by LIM-kinase, Nature, vol.393, pp.805-809, 1998.

T. Arimura, A. Helbling-leclerc, C. Massart, S. Varnous, F. Niel et al., Mouse model carrying H222P Lmna mutation develops muscular dystrophy and dilated cardiomyopathy similar to human striated muscle laminopathies, Hum. Mol. Genet, vol.14, pp.155-169, 2005.
URL : https://hal.archives-ouvertes.fr/hal-00165763

T. Arimura, R. Takeya, T. Ishikawa, T. Yamano, A. Matsuo et al., Dilated cardiomyopathy-associated FHOD3 variants impairs the ability to induce activation of transcription factor serum response factor, Circ. J, vol.77, pp.2990-2993, 2013.

J. Bai, J. H. Hartwig, P. , and N. , SALS, a WH2-domain-containing protein, promotes sarcomeric actin filament elongation from pointed ends during Drosophila muscle growth, Dev. Cell, vol.13, pp.828-842, 2007.

J. R. Bamburg, A. Mcgouch, and S. Ono, Putting a new twist on actin: ADF/cofilins modulate actin dynamics, Trends Cell Biol, vol.9, pp.364-370, 1999.

G. Bonne, M. R. Di-barletta, S. Varnous, H. M. Becane, E. H. Hammouda et al., Mutations in the gene encoding lamin A/C cause autosomal dominant Emery-Dreifuss muscular dystrophy, Nat. Genet, vol.21, pp.285-288, 1999.
DOI : 10.1038/6799

J. F. Casella, S. Craig, W. Maack, and A. E. Brown, Cap Z(36/32), a barbed end actin-capping protein, is a component of the Z-line of skeletal muscle, J. Cell Biol, vol.105, pp.371-379, 1987.

M. Chatzifrangkeskou, G. Bonne, and A. Muchir, Nuclear envelope and striated muscle diseases, Curr. Opin. Cell Biol, vol.32, pp.1-6, 2015.
DOI : 10.1016/j.ceb.2014.09.007

D. Chereau, M. Boczkowska, A. Skwarek-maruszewska, I. Fujiwara, D. B. Hayes et al., Leiomodin is an actin filament nucleator in muscle cells, Science, vol.320, pp.239-243, 2008.
DOI : 10.1126/science.1155313

URL : http://europepmc.org/articles/pmc2845909?pdf=render

J. C. Choi, W. Wu, A. Muchir, S. Iwata, S. Homma et al., Dual specificity phosphatase 4 mediates cardiomyopathy caused by lamin A/C (LMNA) gene mutation, J. Biol. Chem, vol.287, pp.40513-40524, 2012.
DOI : 10.1074/jbc.m112.404541

URL : http://www.jbc.org/content/287/48/40513.full.pdf

J. C. Choi, A. Muchir, W. Wu, S. Iwata, S. Homma et al., Temsirolimus activates autophagy and ameliorates cardiomyopathy caused by lamin A/C gene mutation, Sci. Transl. Med, vol.4, pp.144-102, 2012.
DOI : 10.1126/scitranslmed.3003875

URL : http://europepmc.org/articles/pmc3700376?pdf=render

E. Clarkson, C. F. Costa, and L. M. Machesky, Congenital myopathies: diseases of the actin cytoskeleton, J. Pathol, vol.204, pp.407-417, 2004.
DOI : 10.1002/path.1648

URL : https://onlinelibrary.wiley.com/doi/pdf/10.1002/path.1648

M. Crisp, Q. Liu, K. Roux, J. B. Rattner, C. Shanahan et al., Coupling of the nucleus and cytoplasm: role of the LINC complex, J. Cell Biol, vol.172, pp.41-53, 2006.

D. 'amico, A. Graziano, C. Pacileo, G. Petrini, S. Nowak et al., Fatal hypertrophic cardiomyopathy and nemaline myopathy associated with ACTA1 K336E mutation, Neuromuscul. Disord, vol.16, pp.548-552, 2006.

E. Dominguez, T. Marais, N. Chatauret, S. Benkhelifa-ziyyat, S. Duque et al., Intravenous scAAV9 delivery of a codon-optimized SMN1 sequence rescues SMA mice, Hum. Mol. Genet, vol.20, pp.681-693, 2011.

D. Fatkin, C. Macrae, T. Sasaki, M. R. Wolff, M. Porcu et al., Missense mutations in the rod domain of the lamin A/C gene as causes of dilated cardiomyopathy and conduction-system disease, N. Engl. J. Med, vol.341, pp.1715-1724, 1999.

J. Field, D. Z. Ye, M. Shinde, F. Liu, K. J. Schillinger et al., CAP2 in cardiac conduction, sudden cardiac deatch and eye development, Sci. Rep, vol.5, p.17256, 2015.

D. Z. Fisher, N. Chaudhary, and G. Blobel, cDNA sequencing of nuclear lamins A and C reveals primary and secondary structural homology to intermediate filament proteins, Proc. Natl. Acad. Sci. USA, vol.83, pp.6450-6454, 1986.

E. S. Folker, C. Östlund, G. W. Luxton, H. J. Worman, and G. G. Gundersen, Lamin A variants that cause striated muscle disease are defective in anchoring transmembrane actin-associated nuclear lines for nuclear movement, Proc. Natl. Acad. Sci. USA, vol.108, pp.131-136, 2011.

R. Gatayama, K. Ueno, H. Nakamura, S. Yanagi, H. Ueda et al., Nemaline myopathy with dilated cardiomyopathy in childhood, Pediatrics, vol.131, pp.1986-1990, 2013.

F. A. Gonzalez, D. L. Raden, D. , and R. J. , Identification of substrate recognition determinants for human ERK1 and ERK2 protein kinases, J. Biol. Chem, vol.266, pp.22159-22163, 1991.

C. M. Hale, A. L. Shrestha, S. B. Khatau, P. J. Stewart-hutchinson, L. Hernandez et al., Dysfunctional connections between the nucleus and the actin and microtubule networks in laminopathic models, Biophys. J, vol.95, pp.5462-5475, 2008.

C. Y. Ho, D. E. Jaalouk, M. K. Vartiainen, and J. Lammerding, Lamin A/C and emerin regulate MKL1-SRF activity by modulating actin dynamics, Nature, vol.497, pp.507-511, 2013.

T. Iskratsch, S. Lange, J. Dwyer, A. L. Kho, C. Dos-remedios et al., Formin follows function: a muscle-specific isoform of FHOD3 is regulated by CK2 phosphorylation and promotes myofibril maintenance, J. Cell Biol, vol.191, pp.1159-1172, 2010.

A. B. Johnston, A. Collins, and B. L. Goode, High-speed depolymerization at actin filaments ends jointly catalyzed by Twinfilin and Srv2/CAP, Nat. Cell Biol, vol.17, pp.1504-1511, 2015.

G. Kanellos, J. Zhou, H. Patel, R. A. Rigway, D. Huels et al., ADF and cofilin1 control actin stress fibers, nuclear integrity, and cell survival, Cell Rep, vol.13, pp.1-16, 2015.

-. Kan, M. Takeya, R. Abe, T. Kitajima, N. Nishida et al., , 2012.

, Mammalian formin Fhod3 plays an essential role in cardiogenesis by organizing myofibrillogenesis, Biol. Open, vol.1, pp.889-896

A. L. Kho, S. Perera, A. Alexandrovich, and M. Gautel, The sarcomeric cytoskeleton as a target for pharmacological intervention, Curr. Opin. Pharmacol, vol.12, pp.347-354, 2012.

V. Kooij, M. C. Viswanathan, D. I. Lee, P. P. Rainer, W. Schmidt et al., Profilin modulates sarcomeric organization and mediates cardiomyocyte hypertrophy, Cardiovasc Res, vol.110, pp.238-248, 2016.

S. Labeit and B. Kolmerer, Titins: giant proteins in charge of muscle ultrastructure and elasticity, Science, vol.270, pp.293-296, 1995.

J. Lammerding, P. C. Schulze, T. Takahasjhi, S. Kozlov, T. Sullivan et al., Lamin A/C deficiency causes defective nuclear mechanics and mechanotransduction, J. Clin. Invest, vol.113, pp.370-378, 2004.

S. Lange, E. Ehler, and M. Gautel, From A to Z and back? Multicompartment proteins in the sarcomere, Trends Cell Biol, vol.16, pp.11-18, 2006.

J. S. Lee, C. M. Hale, P. Panorchan, S. B. Khatau, J. P. George et al., Nuclear lamin A/C deficiency induces defects in cell mechanics, polarization, and migration, Biophys. J, vol.93, pp.2542-2552, 2007.
DOI : 10.1529/biophysj.106.102426

URL : https://doi.org/10.1529/biophysj.106.102426

F. Lin and H. J. Worman, Structural organization of the human gene encoding nuclear lamin A and nuclear lamin C, J. Biol. Chem, vol.268, pp.16321-16326, 1993.

R. Littlefield, A. Almenar-queralt, and V. M. Fowler, Actin dynamics at pointed ends regulates thin filament length in striated muscle, Nat. Cell Biol, vol.3, pp.544-551, 2001.
DOI : 10.1038/35078517

M. Maekawa, T. Ishizaki, S. Boku, N. Watanabe, A. Fujita et al., Signaling from Rho to the actin cytoskeleton through protein kinases ROCK and LIMkinase, Science, vol.285, pp.895-898, 1999.

F. D. Mckeon, M. W. Kirschner, and D. Caput, Homologies in both primary and secondary structure between nuclear envelope and intermediate filament proteins, Nature, vol.319, pp.463-468, 1986.

A. Mir, M. Lemler, C. Ramaciotti, S. Blalock, and C. Ikemba, Hypertrophic cardiomyopathy in a neonate associated with nemaline myopathy, Congenit. Heart Dis, vol.7, pp.37-41, 2012.
DOI : 10.1111/j.1747-0803.2011.00588.x

L. C. Mounkes, S. V. Kozlov, J. N. Rottman, and C. L. Stewart, Expression of an LMNA-N195K variant of A-type lamins results in cardiac conduction defects and death in mice, Hum. Mol. Genet, vol.14, pp.2167-2180, 2005.

A. Muchir, P. Pavlidis, V. Decostre, A. J. Herron, T. Arimura et al., Activation of MAPK pathway links LMNA mutations to cardiomyopathy in Emery-Dreifuss Muscular dystrophy, J. Clin. Invest, vol.117, pp.1282-1293, 2007.

A. Muchir, W. Wu, J. C. Choi, S. Iwata, J. Morrow et al., Abnormal p38? mitogen-activated protein kinase signaling in dilated cardiomyopathy caused by lamin A/C gene mutation, Hum. Mol. Genet, vol.21, pp.4325-4333, 2012.
DOI : 10.1093/hmg/dds265

URL : https://academic.oup.com/hmg/article-pdf/21/19/4325/1579435/dds265.pdf

A. Muchir, S. A. Reilly, W. Wu, S. Iwata, S. Homma et al., Treatment with selumetinib preserves cardiac function and improves survival in cardiomyopathy caused by mutation in the lamin A/C gene, Cardiovasc. Res, vol.93, pp.311-319, 2012.

A. Muchir, Y. J. Kim, S. A. Reilly, W. Wu, J. C. Choi et al., Inhibition of extracellular signalregulated kinase ½ signaling has beneficial effects on skeletal muscle in a mouse model of Emery-Dreifuss muscular dystrophy caused by lamin A/C gene mutation, Skelet. Muscle, vol.3, p.17, 2013.
URL : https://hal.archives-ouvertes.fr/inserm-00842001

S. Nicholson-dykstra, H. N. Higgs, H. , and E. S. , Actin dynamics: growth from dendritic branches, Curr. Biol, vol.15, pp.346-357, 2005.

V. Nikolova-krstevski, C. Leimena, X. H. Xiao, S. Kesteven, J. C. Tan et al., Nesprin-1 and actin contribute to nuclear and cytoskeletal defects in lamin A/C-deficient cardiomyopathy, J. Mol. Cell. Cardiol, vol.50, pp.479-486, 2011.

S. Ono, Mechanism of depolymerization and severing of actin filaments and its significance in cytoskeletal dynamics, Int. Rev. Cytol, vol.258, pp.1-82, 2007.

S. Ono, Dynamic regulation of sarcomeric actin filaments in striated muscle, Cytoskeleton, vol.67, pp.677-692, 2010.

V. O. Paavilainen, E. Bertling, S. Falck, and P. Lappalainen, Regulation of cytoskeletal dynamics by actinmonomer-binding proteins, Trends Cell Biol, vol.14, pp.386-394, 2004.

C. T. Pappas, P. A. Krieg, and C. C. Gregorio, Nebulin regulates actin filament lengths by a stabilization mechanism, J. Cell Biol, vol.189, pp.859-870, 2010.

C. T. Pappas, R. M. Mayfield, C. Henderson, N. Jamilpour, C. Cover et al., Knockout of Lmod2 results in shorter thin filaments followed by dilated cardiomyopathy and juvenile lethality, Proc. Natl. Acad. Sci. USA, vol.112, pp.13573-13578, 2015.

V. Peche, S. Shekar, M. Leichter, H. Korte, R. Schröder et al., CAP2, cyclase-associated protein 2, is a dual compartment, protein. Cell. Mol. Life Sci, vol.64, pp.2702-2715, 2007.

V. S. Peche, T. A. Holak, B. D. Burgute, K. Kosmas, S. P. Kale et al., Ablation of cyclaseassociated protein 2 (CAP2) leads to cardiomyopathy, Cell. Mol. Life Sci, vol.70, pp.527-543, 2013.

F. Ponchel, C. Toomes, K. Bransfield, F. T. Leong, S. H. Douglas et al., Real-time PCR based on SYBER-Green I fluorescence: an alternative to the TaqMan assay for a relative quantification of gene rearrangements, gene amplifications and micro gene deletions, BMC Biotechnol, vol.3, p.18, 2003.

M. J. Puckelwartz, E. J. Kessler, Y. Zhang, D. Hodzic, N. Randles et al., Disruption of nesprin-1 produces an Emery-Dreifuss muscular dystrophy-like phenotype in mice, Hum. Mol. Genet, vol.18, pp.607-620, 2009.

M. J. Puckelwartz, E. J. Kessler, G. Kim, M. M. Dewitt, Y. Zhang et al., Nesprin-1 mutations in human and murine cardiomyopathy, J. Mol. Cell. Cardiol, vol.48, pp.600-608, 2010.

L. Ritchey, C. , and R. , Aurora A kinase modulates actin cytoskeleton through phosphorylation of cofilin: implication in the mitotic process, Bioch Biophys Acta, vol.1843, pp.2719-2729, 2014.

M. Rosado, C. F. Barber, C. Berciu, S. Feidman, S. J. Birren et al., Critical roles for multiples formins during cardiac myofibril development and repair, Mol. Biol. Cell, vol.25, pp.811-827, 2014.

R. S. Rosenson, G. H. Mudge, . Jr, and M. G. Sutton, Nemaline cardiomyopathy, Am. J. Cardiol, vol.58, pp.175-177, 1986.

J. M. Sanger and J. W. Sanger, The dynamic Z bands of striated muscle cells, Sci. Signal, vol.1, p.37, 2008.

A. Skwarek-maruszewska, P. Hotulainen, P. K. Mattila, and P. Lappalainen, Contractility dependent actin dynamics in cardiomyocyte sarcomeres, J. Cell Sci, vol.122, pp.2119-2126, 2009.

M. L. Skyllouriotis, M. Marx, P. Skyllouriotis, R. Bittner, and M. Wimmer, Nemaline myopathy and cardiomyopathy, Pediatr. Neurol, vol.20, pp.319-321, 1999.

D. A. Starr and H. N. Fridolfsson, Interactions between nuclei and the cytoskeleton are mediated by SUNKASH nuclear-envelope bridges, Annu. Rev. Cell. Dev. Biol, vol.26, pp.421-444, 2010.

T. Sumi, K. Matsumoto, Y. Takai, and T. Nakamura, Cofilin phosphorylation and actin cytoskeletal dynamics regulated by Rho-and Cdc42-activated LIM-kinase 2, J. Cell Biol, vol.147, pp.1519-1532, 1999.

K. Subramanian, D. Gianni, C. Balla, G. E. Assenza, M. Joshi et al., Cofilin-2 phosphorylation and sequestratiuon in myocardial aggregates, J. Am. Coll. Cardiol, vol.65, pp.1199-1214, 2015.

H. Suzuki, M. Komiyama, A. Konno, and Y. Shimada, Exchangeability of actin in cardiac myocytes and fibroblasts as determined by fluorescence photobleaching recovery, Tissue Cell, vol.30, pp.274-280, 1998.

K. Taniguchi, R. Takeya, S. Suetsugu, M. Kan-o, M. Narusawa et al., Mammalian formin fhod3 regulates actin assembly and sarcomere organization in striated muscles, J. Biol. Chem, vol.284, pp.29873-29881, 2009.

J. A. Towbin and N. E. Bowles, The failing heart, Nature, vol.10, pp.227-233, 2002.

T. Tsukada, C. T. Pappas, N. Moroz, P. B. Antin, A. S. Kostyulova et al., Leiomodin-2 is an antagonist of tropomodulin-1 at the pointed end of the thin filaments in cardiac muscle, J. Cell Sci, vol.123, pp.3136-3145, 2010.

C. L. Van-antwerpen, S. M. Gospe, . Jr, and M. P. Dentinger, Nemaline myopathy associated with hypertrophic cardiomyopathy, Pediatr. Neurol, vol.4, pp.306-308, 1988.

M. Van-troys, L. Huyck, S. Leyman, S. Dhaese, J. Vandekerkhove et al., Ins and outs of ADF/cofilin activity and regulation, Eur. J. Cell Biol, vol.87, pp.649-667, 2008.

J. Wang, N. Shaner, B. Mittal, Q. Zhou, J. Chen et al., Dynamics of Z-band based proteins in developing skeletal muscle cells, Cell Motil. Cytoskeleton, vol.61, pp.34-48, 2005.

I. Wortzel and R. Seger, The ERK cascade: distinct functions with various subcellular organelles, Genes Cancer, vol.2, pp.195-209, 2011.
DOI : 10.1177/1947601911407328

URL : http://europepmc.org/articles/pmc3128630?pdf=render

W. Wu, A. Muchir, J. Shan, G. Bonne, and H. J. Worman, Mitogen-activated protein kinase inhibitors improve heart function and prevent fibrosis in cardiomyopathy caused by mutation in lamin A/C gene, Circulation, vol.123, pp.53-61, 2011.

W. Wu, S. Iwata, S. Homma, H. J. Worman, and A. Muchir, Depletion of extracellular signal-regulated kinase 1 in mice with cardiomyopathy caused by lamin A/C gene mutation partially prevents pathology before isoenzyme activation, Hum. Mol. Genet, vol.23, pp.1-11, 2014.

S. Yamashiro, E. A. Cox, D. L. Baillie, J. D. Hardin, and S. Ono, Sarcomeric actin organization is synergistically promoted by tropomodulin, ADF/cofilin, AIP1, and profiling in C. elegans, J. Cell Sci, vol.121, pp.3867-3877, 2008.
DOI : 10.1242/jcs.040477

URL : http://jcs.biologists.org/content/121/23/3867.full.pdf

N. Yang, O. Higuchi, K. Ohashi, K. Nagata, A. Wada et al., Cofilin phosphorylation by LIM-kinase 1 and its role in Rac-mediated actin reorganization, Nature, vol.393, pp.809-812, 1998.
DOI : 10.1038/31735

Y. Yoo, H. J. Ho, C. Wang, and J. L. Guan, Tyrosine phosphorylation of cofilin at Y68 by v-Src leads to its degradation through ubiquitin-proteasome pathway, Oncogene, vol.29, pp.263-272, 2010.
DOI : 10.1038/onc.2009.319

URL : https://www.nature.com/articles/onc2009319.pdf

B. Yuan, P. Wan, D. Chu, J. Nie, Y. Cao et al., A cardiomyocyte-specific Wdr1 knockout demonstrates essential functional roles for actin disassembly during myocardial growth and maintenance in mice, Am. J. Pathol, vol.184, 1967.
DOI : 10.1016/j.ajpath.2014.04.007

M. Yuen, S. A. Sandaradura, J. J. Dowling, A. S. Kostyukova, N. Moroz et al., Leiomodin-3 dysfunction results in thin filament disorganization and nemaline myopathy, J. Clin. Invest, vol.124, pp.4693-4708, 2014.
DOI : 10.1172/jci80057

URL : http://www.jci.org/articles/view/80057/files/pdf

Q. Zhang, C. Bethmann, N. F. Worth, J. D. Davies, C. Wasner et al., Nesprin-1 and-2 are involved in the pathogenesis of Emery-Dreifuss muscular dystrophy and are critical for nuclear envelope integrity, Hum. Mol. Genet, vol.16, pp.2816-2833, 2007.

M. Zwerger, D. E. Jaalouk, M. L. Lombardi, P. Isermann, M. Mauermann et al., Myopathic lamin mutations impair nuclear stability in cells and tissue and disrupt nucleo-cytoskeletal coupling, Hum. Mol. Genet, vol.22, pp.2335-2349, 2013.
DOI : 10.1093/hmg/ddt079

URL : https://academic.oup.com/hmg/article-pdf/22/12/2335/14138854/ddt079.pdf

F. Accornero, Genetic Analysis of Connective Tissue Growth Factor as an Effector of Transforming Growth Factor ? Signaling and Cardiac Remodeling, Molecular and cellular biology, vol.35, issue.12, pp.2154-64, 2015.

U. Aebi, The nuclear lamina is a meshwork of intermediate-type filaments, Nature, vol.323, issue.6088, pp.560-564, 1986.

A. K. Agarwal, Zinc metalloproteinase ZMPSTE24, is mutated in mandibuloacral dysplasia, Human Molecular Genetics, vol.12, issue.16, pp.1995-2001, 2003.

R. Agarwal, Add-on angiotensin II receptor blockade lowers urinary transforming growth factor-beta levels, American Journal of Kidney Diseases, vol.39, issue.3, pp.486-492, 2002.

B. J. Agnew, L. S. Minamide, and J. R. Bamburg, Reactivation of phosphorylated actin depolymerizing factor and identification of the regulatory site, Journal of Biological Chemistry, vol.270, issue.29, pp.17582-17587, 1995.

P. B. Agrawal, Nemaline myopathy with minicores caused by mutation of the CFL2 gene encoding the skeletal muscle actin-binding protein, cofilin-2, American Journal of Human Genetics, vol.80, issue.1, pp.162-167, 2007.

P. B. Agrawal, Normal myofibrillar development followed by progressive sarcomeric disruption with actin accumulations in a mouse Cfl2 knockout demonstrates requirement of cofilin-2 for muscle maintenance, Human Molecular Genetics, vol.21, issue.10, pp.2341-2356, 2012.

R. Ahuja, Cordon-Bleu Is an Actin Nucleation Factor and Controls Neuronal Morphology, Cell, vol.131, issue.2, pp.337-350, 2007.

A. Akinleye, MEK and the inhibitors: from bench to bedside, Journal of hematology & oncology, vol.6, issue.1, p.27, 2013.

C. Alarcon, Nuclear CDKs Drive Smad Transcriptional Activation and Turnover in BMP and TGF-? Pathways, Cell, vol.139, issue.4, pp.757-769, 2009.

M. Alsheimer and R. Benavente, Change of Karyoskeleton during Mammalian Spermatogenesis: Expression Pattern of Nuclear Lamin C2 and Its Regulation, Experimental Cell Research, vol.228, issue.2, pp.181-188, 1996.

M. Amendola and B. Van-steensel, Mechanisms and dynamics of nuclear lamina-genome interactions, Current Opinion in Cell Biology, vol.28, pp.61-68, 2014.

V. Andrés and J. M. González, Role of A-type lamins in signaling, transcription, and chromatin organization, The Journal of Cell Biology, vol.187, issue.7, pp.945-957, 2009.

E. Andrianantoandro and T. D. Pollard, Mechanism of Actin Filament Turnover by Severing and Nucleation at Different Concentrations of ADF/Cofilin, Molecular Cell, vol.24, issue.1, pp.13-23, 2006.

J. P. Annes, J. S. Munger, and D. B. Rifkin, Making sense of latent TGFbeta activation, Journal of cell science, vol.116, pp.217-241, 2003.

T. Arimura, Dilated Cardiomyopathy-Associated FHOD3 Variant Impairs the Ability to Induce Activation of Transcription Factor Serum Response Factor, Circulation Journal, vol.77, issue.12, pp.2990-2996, 2013.

T. Arimura, Improvement of left ventricular dysfunction and of survival prognosis of dilated cardiomyopathy by administration of calcium sensitizer SCH00013 in a mouse model, Journal of the American College of Cardiology, vol.55, issue.14, pp.1503-1508, 2010.

T. Arimura, Mouse model carrying H222P-Lmna mutation develops muscular dystrophy and dilated cardiomyopathy similar to human striated muscle laminopathies, Human Molecular Genetics, vol.14, issue.1, pp.155-169, 2005.
URL : https://hal.archives-ouvertes.fr/hal-00165763

D. Aronson, S. D. Dufresne, and L. J. Goodyear, Contractile Activity Stimulates the c-Jun NH2-terminal Kinase Pathway in Rat Skeletal Muscle, Journal of Biological Chemistry, vol.272, issue.41, pp.25636-25640, 1997.

A. Ashworth, The amino acid sequence of a mammalian MAP kinase kinase, Oncogene, vol.7, issue.12, pp.2555-2561, 1992.

. Bakin, Phosphatidylinositol 3-kinase function is required for transforming growth factor betamediated epithelial to mesenchymal transition and cell migration, The Journal of biological chemistry, vol.275, issue.47, pp.36803-36813, 2000.

H. I. Balcer, Coordinated Regulation of Actin Filament Turnover by a High-Molecular-Weight Srv2/CAP Complex, Cofilin, Profilin, and Aip1, Current Biology, vol.13, issue.24, pp.2159-2169, 2003.

J. R. Bamburg, Proteins of the ADF/cofilin family: essential regulators of actin dynamics, Annual review of cell and developmental biology, vol.15, issue.1, pp.185-230, 1999.

J. R. Bamburg and B. W. Bernstein, ADF/cofilin. Current biology, vol.18, issue.7, pp.273-278, 2008.

U. Bartram and C. P. Speer, The Role of Transforming Growth Factor ? in Lung Development and Disease, Chest, vol.125, issue.2, pp.754-765, 2004.

H. M. Bécane, High incidence of sudden death with conduction system and myocardial disease due to lamins A and C gene mutation, Pacing and clinical electrophysiology, vol.23, issue.11, pp.1661-1667, 2000.

L. Bengtsson, What MAN1 does to the Smads: TGF??/BMP signaling and the nuclear envelope, FEBS Journal, vol.274, issue.6, pp.1374-1382, 2007.

L. Bengtsson and H. Otto, LUMA interacts with emerin and influences its distribution at the inner nuclear membrane, Journal of cell science, vol.121, pp.536-584, 2008.

K. Ben-harush, The Supramolecular Organization of the C. elegans Nuclear Lamin Filament, Journal of Molecular Biology, vol.386, issue.5, pp.1392-1402, 2009.

S. Berger, R. L. Shoeman, and P. Traub, Detection of dense intra-and perinuclear 10nm filament systems by whole mount and embedment-free electron microscopy in several species of the green algal order Dasycladales, Protoplasma, vol.190, pp.204-220, 1996.

M. O. Bergo, Zmpste24 deficiency in mice causes spontaneous bone fractures, muscle weakness, and a prelamin A processing defect, Proceedings of the National Academy of Sciences of the United States of America, vol.99, pp.13049-54, 2002.

J. H. Van-berlo, Meta-analysis of clinical characteristics of 299 carriers of LMNA gene mutations: Do lamin A/C mutations portend a high risk of sudden death, Journal of Molecular Medicine, vol.83, issue.1, pp.79-83, 2005.

J. H. Van-berlo, D. Duboc, and Y. M. Pinto, Often seen but rarely recognised: cardiac complications of lamin A/C mutations, European heart journal, vol.25, issue.10, pp.812-816, 2004.

O. Bernard, Lim kinases, regulators of actin dynamics, International Journal of Biochemistry and Cell Biology, vol.39, issue.6, pp.1071-1076, 2007.

P. Bernasconi, Expression of transforming growth factor-beta 1 in dystrophic patient muscles correlates with fibrosis. Pathogenetic role of a fibrogenic cytokine, The Journal of clinical investigation, vol.96, issue.2, pp.1137-1181, 1995.

B. W. Bernstein and J. R. Bamburg, Tropomyosin binding to F-actin protects the F-actin from disassembly by brain actin-depolymerizing factor (ADF), Cell Motility, vol.2, issue.1, pp.1-8, 1982.

E. Bertling, Cyclase-associated protein 1 (CAP1) promotes cofilin-induced actin dynamics in mammalian nonmuscle cells, Molecular biology of the cell, vol.15, issue.5, pp.2324-2358, 2004.

A. T. Bertrand, Cellular microenvironments reveal defective mechanosensing responses and elevated YAP signaling in LMNA-mutated muscle precursors, Journal of cell science, vol.127, pp.2873-84, 2014.

A. T. Bertrand, DelK32-lamin A/C has abnormal location and induces incomplete tissue maturation and severe metabolic defects leading to premature death, Human Molecular Genetics, vol.21, issue.5, pp.1037-1048, 2012.
URL : https://hal.archives-ouvertes.fr/hal-00672148

S. Bione, E. Maestrini, and S. Rivella, Identification of a novel X-linked gene responsible for EmeryDreifuss muscular dystrophy, Nature genetics, vol.8, issue.4, pp.323-327, 1994.

S. Bione, E. Maestrini, and S. Rivella, Dreifuss muscular dystrophy, Nature genetics, vol.8, p.323, 1994.

F. Blanchette, Cross-talk between the p42/p44 MAP kinase and Smad pathways in transforming growth factor beta 1-induced furin gene transactivation, The Journal of biological chemistry, vol.276, issue.36, pp.33986-94, 2001.

L. Blanchoin and T. D. Pollard, Interaction of actin monomers with Acanthamoeba actophorin (ADF/cofilin) and profilin, Journal of Biological Chemistry, vol.273, issue.39, pp.25106-25111, 1998.

L. Blanchoin, T. D. Pollard, and R. D. Mullins, Interactions of ADF/cofilin, Arp2/3 complex, capping protein and profilin in remodeling of branched actin filament networks, Current Biology, vol.10, issue.20, pp.1273-1282, 2000.

A. A. Bobkov, Cofilin (ADF) Affects Lateral Contacts in F-actin, Journal of Molecular Biology, vol.337, issue.1, pp.93-104, 2004.

A. A. Bobkov, Cooperative effects of cofilin (ADF) on actin structure suggest allosteric mechanism of cofilin function, Journal of Molecular Biology, vol.356, issue.2, pp.325-334, 2006.

G. Bonne, Mutations in the gene encoding lamin A/C cause autosomal dominant Emery-Dreifuss muscular dystrophy, Nature Genetics, vol.21, pp.285-288, 1999.

W. A. Border and N. A. Noble, TGF-? in kidney fibrosis: A target for gene therapy, Kidney International, vol.51, issue.5, pp.1388-1396, 1997.
DOI : 10.1038/ki.1997.190

URL : https://doi.org/10.1038/ki.1997.190

J. Borrego-pinto, Samp1 is a component of TAN lines and is required for nuclear movement, Journal of Cell Science, vol.125, pp.1099-1105, 2012.

W. M. Brieher, Rapid actin monomer-insensitive depolymerization of Listeria actin comet tails by cofilin, coronin, and Aip1, The Journal of cell biology, vol.175, issue.2, pp.315-339, 2006.

J. L. Broers, Decreased mechanical stiffness in LMNA-/-cells is caused by defective nucleocytoskeletal integrity: implications for the development of laminopathies, Human molecular genetics, vol.13, issue.21, pp.2567-80, 2004.

J. L. Broers, Nuclear lamins: laminopathies and their role in premature ageing, Physiological reviews, vol.86, issue.3, pp.967-1008, 2006.

J. L. Broers, Both lamin A and lamin C mutations cause lamina instability as well as loss of internal nuclear lamin organization, Experimental Cell Research, vol.304, issue.2, pp.582-592, 2005.

M. Brosig, Interfering with the connection between the nucleus and the cytoskeleton affects nuclear rotation, mechanotransduction and myogenesis, International Journal of Biochemistry and Cell Biology, vol.42, issue.10, pp.1717-1728, 2010.

C. Brown, Novel and recurrent EMD mutations in patients with Emery-Dreifuss muscular dystrophy, identify exon 2 as a mutation hot spot, Journal of human genetics, vol.56, issue.8, pp.589-94, 2011.

A. Brussino, A family with autosomal dominant leukodystrophy linked to 5q23.2-q23.3 without lamin B1 mutations, European journal of neurology, vol.17, issue.4, pp.541-550, 2010.

B. Burke and C. L. Stewart, The nuclear lamins: flexibility in function, Nature Reviews Molecular Cell Biology, vol.14, issue.1, pp.13-24, 2012.

V. Butin-israeli, Nuclear lamin functions and disease, Trends in Genetics, vol.28, issue.9, pp.464-471, 2012.

J. F. Callahan, Identification of Novel Inhibitors of the Transforming Growth Factor ?1 (TGF-?1) Type 1 Receptor (ALK5), Journal of Medicinal Chemistry, vol.45, issue.5, pp.999-1001, 2002.

K. G. Campellone and M. D. Welch, A nucleator arms race: cellular control of actin assembly, Nature reviews. Molecular cell biology, vol.11, issue.4, pp.237-51, 2010.

H. Cao and R. Hegele, Nuclear lamin A/C R482Q mutation in canadian kindreds with Dunnigan-type familial partial lipodystrophy, Human molecular genetics, vol.9, issue.1, pp.109-121, 2000.

S. Caputo, The carboxyl-terminal nucleoplasmic region of MAN1 exhibits a DNA binding winged helix domain, Journal of Biological Chemistry, vol.281, issue.26, pp.18208-18215, 2006.
URL : https://hal.archives-ouvertes.fr/hal-00023616

M. F. Carlier and D. Pantaloni, Control of actin dynamics in cell motility, Journal of molecular biology, vol.269, issue.4, pp.459-467, 1997.

J. F. Casella, Cap Z(36/32), a barbed end actin-capping protein, is a component of the Z-line of skeletal muscle, Journal of Cell Biology, vol.105, issue.1, pp.371-379, 1987.

C. Catelain, Myoblasts and embryonic stem cells differentially engraft in a mouse model of genetic dilated cardiomyopathy, Molecular therapy : the journal of the American Society of Gene Therapy, vol.21, issue.5, pp.1064-75, 2013.

M. E. Cattin, Heterozygous LmnadelK32 mice develop dilated cardiomyopathy through a combined pathomechanism of haploinsufficiency and peptide toxicity, Human Molecular Genetics, vol.22, issue.15, pp.3152-3164, 2013.
URL : https://hal.archives-ouvertes.fr/inserm-00826642

B. K. Cenik, Severe myopathy in mice lacking the MEF2/SRF-dependent gene leiomodin-3, The Journal of clinical investigation, vol.125, issue.4, pp.1569-78, 2015.

A. B. Chambliss, The LINC-anchored actin cap connects the extracellular milieu to the nucleus for ultrafast mechanotransduction, Scientific reports, vol.3, p.1087, 2013.

T. J. Chancellor, Actomyosin Tension Exerted on the Nucleus through Nesprin-1 Connections Influences Endothelial Cell Adhesion, Migration, and Cyclic Strain-Induced Reorientation, Biophysical Journal, vol.99, issue.1, pp.115-123, 2010.

W. Chang, Emerin organizes actin flow for nuclear movement and centrosome orientation in migrating fibroblasts, Molecular biology of the cell, vol.24, issue.24, pp.3869-80, 2013.

W. Chang, Linker of nucleoskeleton and cytoskeleton (LINC) complex-mediated actin-dependent nuclear positioning orients centrosomes in migrating myoblasts, Nucleus, vol.6, issue.1, pp.77-88, 2015.

P. Charron, E. Arbustini, and G. Bonne, What Should the Cardiologist know about Lamin Disease ?, Arrhythmia and Electrophysiology Review, vol.1, issue.1, pp.22-28, 2012.

L. Chen, LMNA mutations in atypical Werner's syndrome, Lancet, vol.362, issue.9382, pp.440-445, 2003.

M. M. Chen, CTGF expression is induced by TGF-beta in cardiac fibroblasts and cardiac myocytes: a potential role in heart fibrosis, Journal of molecular and cellular cardiology, vol.32, issue.10, pp.1805-1824, 2000.

R. H. Chen and T. Y. Chang, Involvement of caspase family proteases in transforming growth factor-betainduced apoptosis, Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research, vol.8, issue.7, pp.821-828, 1997.

T. Chen, Transforming growth factor beta type I receptor kinase mutant associated with metastatic breast cancer, Cancer Res, vol.58, issue.21, pp.4805-4810, 1998.

J. Cheng and J. P. Grande, Transforming growth factor-beta signal transduction and progressive renal disease. Experimental biology and medicine (Maywood, N.J.), vol.227, issue.11, pp.943-56, 2002.

D. Chereau, Leiomodin is an actin filament nucleator in muscle cells, Science, issue.5873, pp.239-282, 2008.

S. M. Chin, S. Jansen, and B. L. Goode, TIRF microscopy analysis of human Cof1, Cof2, and ADF effects on actin filament severing and turnover, Journal of Molecular Biology, 2016.

J. E. Chipuk, Bcl-xL blocks transforming growth factor-beta 1-induced apoptosis by inhibiting cytochrome c release and not by directly antagonizing Apaf-1-dependent caspase activation in prostate epithelial cells, The Journal of biological chemistry, vol.276, issue.28, pp.26614-26635, 2001.

J. C. Choi, Temsirolimus activates autophagy and ameliorates cardiomyopathy caused by lamin A/C gene mutation, Science translational medicine, vol.4, issue.144, pp.144-102, 2012.

J. C. Choi and H. J. Worman, Nuclear Envelope Regulation of Signaling Cascades, pp.187-206, 2014.

X. Chu, E-Tmod capping of actin filaments at the slow-growing end is required to establish mouse embryonic circulation, American journal of physiology. Heart and circulatory physiology, vol.284, issue.5, pp.1827-1865, 2003.

A. C. Chung, Smad7 suppresses renal fibrosis via altering expression of TGF-?/Smad3-regulated microRNAs, Molecular Therapy, vol.21, issue.2, pp.388-398, 2013.

M. Ciska, D. Ã. Moreno, and S. De-la-espina, The intriguing plant nuclear lamina, Frontiers in Plant Science, vol.5, p.166, 2014.

L. Clements, Direct interaction between emerin and lamin A. Biochemical and biophysical research communications, vol.267, pp.709-723, 2000.

C. Coffinier, Abnormal development of the cerebral cortex and cerebellum in the setting of lamin B2 deficiency, Proceedings of the National Academy of Sciences of the United States of America, vol.107, pp.5076-81, 2010.

C. Coffinier, Deficiencies in lamin B1 and lamin B2 cause neurodevelopmental defects and distinct nuclear shape abnormalities in neurons, Molecular biology of the cell, vol.22, issue.23, pp.4683-93, 2011.

M. Cohen, Transcriptional repression, apoptosis, human disease and the functional evolution of the nuclear lamina, Trends in Biochemical Sciences, vol.26, issue.1, pp.41-47, 2001.

T. V. Cohen, Defective skeletal muscle growth in lamin A/C-deficient mice is rescued by loss of lap2??, Human Molecular Genetics, vol.22, issue.14, pp.2852-2869, 2013.

P. Collas, E. G. Lund, and A. R. Oldenburg, Closing the (nuclear) envelope on the genome: How nuclear lamins interact with promoters and modulate gene expression, BioEssays, vol.36, issue.1, pp.75-83, 2014.

D. P. Corrigan, Prelamin A endoproteolytic processing in vitro by recombinant Zmpste24, The Biochemical journal, vol.387, pp.129-167, 2005.

C. Crews, A. Alessandrini, and R. Erikson, The primary structure of MEK, a protein kinase that phosphorylates the ERK gene product, Science, vol.258, issue.5081, pp.478-480, 1992.

M. Crisp, Coupling of the nucleus and cytoplasm: Role of the LINC complex, Journal of Cell Biology, vol.172, issue.1, pp.41-53, 2006.

K. N. Dahl, The nuclear envelope lamina network has elasticity and a compressibility limit suggestive of a molecular shock absorber, Journal of Cell Science, vol.117, issue.20, pp.4779-4786, 2004.

K. N. Dahl, A. J. Ribeiro, and J. Lammerding, Nuclear shape, mechanics, and mechanotransduction, Circulation Research, vol.102, issue.11, pp.1307-1318, 2008.

H. R. Dawe, ADF/cofilin controls cell polarity during fibroblast migration, Current Biology, vol.13, issue.3, pp.252-257, 2003.

H. R. Dawe, Nesprin-2 interacts with meckelin and mediates ciliogenesis via remodelling of the actin cytoskeleton, Journal of cell science, vol.122, pp.2716-2742, 2009.

T. Dechat, Lamina-associated polypeptide 2alpha binds intranuclear A-type lamins, J. Cell Sci, vol.113, issue.19, pp.3473-3484, 2000.

T. Dechat and S. A. Adam, Nuclear Lamins. Cold Spring Harbor Perspectives in Biology, vol.2, pp.547-000547, 2010.

T. Dechat, K. Gesson, and R. Foisner, Lamina-Independent Lamins in the Nuclear Interior Serve Important Functions, Cold Spring Harbor Symposia on Quantitative Biology, vol.75, issue.0, pp.533-543, 2010.
DOI : 10.1101/sqb.2010.75.018

R. Derynck and Y. E. Zhang, Smad-dependent and Smad-independent pathways in TGF-beta family signalling, Nature, vol.425, issue.6958, pp.577-584, 2003.
DOI : 10.1038/nature02006

S. Dhe-paganon, Structure of the globular tail of nuclear lamin, Journal of Biological Chemistry, vol.277, issue.20, pp.17381-17384, 2002.

D. Didry, M. F. Carlier, and D. Pantaloni, Synergy between actin depolymerizing factor/cofilin and profilin in increasing actin filament turnover, Journal of Biological Chemistry, vol.273, issue.40, pp.25602-25611, 1998.
DOI : 10.1074/jbc.273.40.25602

URL : http://www.jbc.org/content/273/40/25602.full.pdf

P. Ten-dijke and C. S. Hill, New insights into TGF-beta-Smad signalling, Trends in biochemical sciences, vol.29, issue.5, pp.265-73, 2004.

X. Ding, SUN1 is required for telomere attachment to nuclear envelope and gametogenesis in mice, Developmental cell, vol.12, issue.6, pp.863-72, 2007.
DOI : 10.1016/j.devcel.2007.03.018

URL : https://doi.org/10.1016/j.devcel.2007.03.018

T. Dittmer and T. Misteli, The lamin protein family, Genome Biology, vol.12, issue.5, p.222, 2011.
DOI : 10.1186/gb-2011-12-5-222

URL : https://genomebiology.biomedcentral.com/track/pdf/10.1186/gb-2011-12-5-222

M. Dobaczewski, W. Chen, and N. G. Frangogiannis, Transforming growth factor (TGF)-?? signaling in cardiac remodeling, Journal of Molecular and Cellular Cardiology, vol.51, issue.4, pp.600-606, 2011.
DOI : 10.1016/j.yjmcc.2010.10.033

URL : http://europepmc.org/articles/pmc3072437?pdf=render

S. Dooley and P. Ten-dijke, TGF-?? in progression of liver disease, Cell and Tissue Research, vol.347, issue.1, pp.245-256, 2012.

I. Dorboz, Severe dystonia, cerebellar atrophy, and cardiomyopathy likely caused by a missense mutation in TOR1AIP1, Orphanet Journal of Rare Diseases, vol.9, issue.1, p.174, 2014.
URL : https://hal.archives-ouvertes.fr/hal-01110718

M. Dreger, Nuclear envelope proteomics: novel integral membrane proteins of the inner nuclear membrane, Proceedings of the National Academy of Sciences of the United States of America, vol.98, pp.11943-11951, 2001.

C. Dreuillet, In vivo and in vitro interaction between human transcription factor MOK2 and nuclear lamin A/C, Nucleic Acids Research, vol.30, issue.21, pp.4634-4642, 2002.

M. R. Duncan, Connective tissue growth factor mediates transforming growth factor beta-induced collagen synthesis: down-regulation by cAMP, FASEB journal : official publication of the Federation of American Societies for Experimental Biology, vol.13, issue.13, pp.1774-86, 1999.

M. Dziadzio, N-terminal connective tissue growth factor is a marker of the fibrotic phenotype in scleroderma, QJM : monthly journal of the Association of Physicians, vol.98, issue.7, pp.485-92, 2005.

M. A. Eckersley-maslin, Lamin A/C is expressed in pluripotent mouse embryonic stem cells, Nucleus, vol.4, issue.1, pp.53-60, 2013.

A. E. El-agroudy, Effect of angiotensin II receptor blocker on plasma levels of TGF-beta 1 and interstitial fibrosis in hypertensive kidney transplant patients, Am J Nephrol, vol.23, issue.5, pp.300-306, 2003.

J. Ellenberg and E. Siggia, Nuclear membrane dynamics and reassembly in living cells: targeting of an inner nuclear membrane protein in interphase and mitosis, The Journal of cell biology, vol.138, issue.6, pp.1193-1206, 1997.

L. J. Emerson, Defects in cell spreading and ERK1/2 activation in fibroblasts with lamin A/C mutations, Biochimica et Biophysica Acta-Molecular Basis of Disease, issue.8, pp.810-821, 2009.
URL : https://hal.archives-ouvertes.fr/hal-00506513

B. G. Van-engelen, The lethal phenotype of a homozygous nonsense mutation in the lamin A/C gene, Neurology, vol.64, issue.2, pp.374-380, 2005.

F. H. Epstein, W. A. Border, and N. A. Noble, Transforming Growth Factor ? in Tissue Fibrosis, New England Journal of Medicine, vol.331, issue.19, pp.1286-1292, 1994.

M. Eriksson, Recurrent de novo point mutations in lamin A cause Hutchinson-Gilford progeria syndrome, Nature, vol.423, issue.6937, pp.293-298, 2003.

G. Euler-taimor and J. Heger, The complex pattern of SMAD signaling in the cardiovascular system, Cardiovascular research, vol.69, issue.1, pp.15-25, 2006.

E. Fairley, J. Kendrick-jones, and J. Ellis, The Emery-Dreifuss muscular dystrophy phenotype arises from aberrant targeting and binding of emerin at the inner nuclear membrane, J. Cell Sci, vol.112, issue.15, pp.2571-2582, 1999.

H. Fakhrai, Phase I clinical trial of a TGF-beta antisense-modified tumor cell vaccine in patients with advanced glioma, Cancer Gene Ther, vol.13, issue.12, pp.1052-1060, 2006.

D. Fatkin, Missense mutations in the rod domain of the lamin A/C gene as causes of dilated cardiomyopathy and conduction-system disease, The New England journal of medicine, vol.341, issue.23, pp.1715-1739, 1999.

C. Favreau, Expression of a Mutant Lamin A That Causes Emery-Dreifuss Muscular Dystrophy Inhibits In Vitro Differentiation of C2C12 Myoblasts, Molecular and Cellular Biology, vol.24, issue.4, pp.1481-1492, 2004.

L. E. Felkin, Expression of extracellular matrix genes during myocardial recovery from heart failure after left ventricular assist device support, The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation, vol.28, pp.117-122, 2009.

A. Fidzia?ska and I. Hausmanowa-petrusewicz, Ultrastructural differences between X-linked and autosomal dominant forms of EDMD, Journal of the Neurological Sciences, vol.210, issue.1-2, pp.47-51, 2003.

A. P. Fields and L. J. Thompson, The regulation of mitotic nuclear envelope breakdown: A role for multiple lamin kinases, Progress in Cell Cycle Research, pp.271-286, 1995.

G. A. Finlay, Transforming growth factor-beta 1-induced activation of the ERK pathway/activator protein-1 in human lung fibroblasts requires the autocrine induction of basic fibroblast growth factor, The Journal of biological chemistry, vol.275, issue.36, pp.27650-27656, 2000.

J. Finsterer, Cardiac findings in congenital muscular dystrophies, Pediatrics, vol.126, issue.3, pp.538-583, 2010.

D. Z. Fisher, N. Chaudhary, and G. Blobel, cDNA sequencing of nuclear lamins A and C reveals primary and secondary structural homology to intermediate filament proteins, Cell Biology, vol.83, pp.6450-6454, 1986.

D. Z. Fisher, N. Chaudhary, and G. Blobel, cDNA sequencing of nuclear lamins A and C reveals primary and secondary structural homology to intermediate filament proteins, Proceedings of the National Academy of Sciences of the United States of America, vol.83, pp.6450-6454, 1986.

K. C. Flanders, Interference with transforming growth factor-beta/ Smad3 signaling results in accelerated healing of wounds in previously irradiated skin, The American journal of pathology, vol.163, issue.6, pp.2247-57, 2003.

N. Foeger, Solubility properties and specific assembly pathways of the B-type lamin from Caenorhabditis elegans, Journal of Structural Biology, vol.155, issue.2, pp.340-350, 2006.

R. Foisner and L. Gerace, Integral membrane proteins of the nuclear envelope interact with lamins and chromosomes, and binding is modulated by mitotic phosphorylation, Cell, vol.73, issue.7, pp.1267-1279, 1993.

V. C. Foletta, Direct signaling by the BMP type II receptor via the cytoskeletal regulator LIMK1, Journal of Cell Biology, vol.162, issue.6, pp.1089-1098, 2003.

E. S. Folker, Lamin A variants that cause striated muscle disease are defective in anchoring transmembrane actin-associated nuclear lines for nuclear movement, Proceedings of the National Academy of Sciences of the United States of America, vol.108, pp.131-136, 2011.

K. Frazier, Stimulation of fibroblast cell growth, matrix production, and granulation tissue formation by connective tissue growth factor, The Journal of investigative dermatology, vol.107, issue.3, pp.404-415, 1996.

K. L. Fritz-six, Aberrant myofibril assembly in tropomodulin1 null mice leads to aborted heart development and embryonic lethality, Journal of Cell Biology, vol.163, issue.5, pp.1033-1044, 2003.

L. C. Fuentealba, Integrating Patterning Signals: Wnt/GSK3 Regulates the Duration of the BMP/Smad1 Signal, Cell, vol.131, issue.5, pp.980-993, 2007.

M. Funaba, C. M. Zimmerman, and L. S. Mathews, Modulation of Smad2-mediated signaling by extracellular signal-regulated kinase, Journal of Biological Chemistry, vol.277, issue.44, pp.41361-41368, 2002.
DOI : 10.1074/jbc.m204597200

URL : http://www.jbc.org/content/277/44/41361.full.pdf

K. Furukawa, Cloning of a cDNA for lamina-associated polypeptide 2 (LAP2) and identification of regions that specify targeting to the nuclear envelope, The EMBO journal, vol.14, issue.8, pp.1626-1636, 1995.

K. Furukawa and Y. Hotta, cDNA cloning of a germ cell specific lamin B3 from mouse spermatocytes and analysis of its function by ectopic expression in somatic cells, The EMBO Journal, vol.1, issue.1, pp.97-106, 1993.

K. Furukawa, H. Inagaki, and Y. Hotta, Identification and Cloning of an mRNA Coding for a Germ CellSpecific A-Type, 1994.

V. E. Galkin, A new internal mode in F-actin helps explain the remarkable evolutionary conservation of actin's sequence and structure, Current Biology, vol.12, issue.7, pp.570-575, 2002.

V. E. Galkin, Actin depolymerizing factor stabilizes an existing state of F-actin and can change the tilt of F-actin subunits, Journal of Cell Biology, vol.153, issue.1, pp.75-86, 2001.

V. E. Galkin, ADF/cofilin use an intrinsic mode of F-actin instability to disrupt actin filaments, Journal of Cell Biology, vol.163, issue.5, pp.1057-1066, 2003.
DOI : 10.1083/jcb.200308144

URL : http://jcb.rupress.org/content/163/5/1057.full.pdf

A. Garg, KLHL40 deficiency destabilizes thin filament proteins and promotes nemaline myopathy, The Journal of clinical investigation, vol.124, issue.8, pp.3529-3568, 2014.
DOI : 10.1172/jci74994

URL : http://www.jci.org/articles/view/74994/files/pdf

L. Gerace, C. Comeau, and M. Benson, Organization and modulation of nuclear lamina structure, Journal of Cell Science, vol.1, pp.137-160, 1984.

K. Gesson, A-type lamins bind both hetero-and euchromatin, the latter being regulated by laminaassociated polypeptide 2 alpha, Genome Research, 2016.
DOI : 10.1101/gr.196220.115

URL : http://genome.cshlp.org/content/26/4/462.full.pdf

C. Glass, The alpha-helical rod domain of human lamins A and C contains a chromatin binding site, The EMBO journal, vol.12, issue.11, pp.4413-4424, 1993.

A. Gohla, J. Birkenfeld, and G. M. Bokoch, Chronophin, a novel HAD-type serine protein phosphatase, regulates cofilin-dependent actin dynamics, Nature cell biology, vol.7, pp.21-29, 2005.

A. Gohla and G. M. Bokoch, 14-3-3 Regulates actin dynamics by stabilizing phosphorylated cofilin, Current Biology, vol.12, issue.19, pp.1704-1710, 2002.

D. S. Gokhin, Tropomodulin 1 directly controls thin filament length in both wild-type and tropomodulin 4-deficient skeletal muscle, Development, issue.24, pp.4351-62, 2015.

D. S. Gokhin and V. M. Fowler, A two-segment model for thin filament architecture in skeletal muscle, Nature Reviews Molecular Cell Biology, vol.14, issue.2, pp.113-119, 2013.

P. Goldschmidt-clermont, Regulation of phospholipase C-gamma 1 by profilin and tyrosine phosphorylation, Science, issue.4998, pp.1231-1233, 1991.

E. D. Goley and M. D. Welch, The ARP2/3 complex: an actin nucleator comes of age, Nature reviews. Molecular cell biology, vol.7, issue.10, pp.713-739, 2006.

J. M. González, Fast regulation of AP-1 activity through interaction of lamin A/C, ERK1/2, and c-Fos at the nuclear envelope, The Journal of cell biology, vol.183, issue.4, pp.653-66, 2008.

K. J. Gordon and G. C. Blobe, Role of transforming growth factor-beta superfamily signaling pathways in human disease, Biochimica et biophysica acta, vol.1782, issue.4, pp.197-228, 2008.

I. Gotic and M. Leschnik, Lamina-associated polypeptide 2? loss impairs heart function and stress response in mice, Circulation Research, vol.106, issue.2, pp.346-353, 2010.

I. Gotic and W. M. Schmidt, Loss of LAP2?? delays satellite cell differentiation and affects postnatal fibertype determination, Stem Cells, vol.28, issue.3, pp.480-488, 2010.

R. M. Grady, Syne proteins anchor muscle nuclei at the neuromuscular junction, Proceedings of the National Academy of Sciences, vol.102, issue.12, pp.4359-4364, 2005.

J. Gravning, CCN2/CTGF attenuates myocardial hypertrophy and cardiac dysfunction upon chronic pressure-overload, International journal of cardiology, vol.168, issue.3, pp.2049-56, 2013.

J. Gravning, Myocardial connective tissue growth factor (CCN2/CTGF) attenuates left ventricular remodeling after myocardial infarction, PloS one, vol.7, issue.12, p.52120, 2012.

C. C. Gregorio, Requirement of pointed-end capping by tropomodulin to maintain actin filament length in embryonic chick cardiac myocytes, Nature, vol.377, issue.6544, pp.83-86, 1995.

D. Gremm and A. Wegner, Gelsolin as a calcium-regulated actin filament-capping protein, European Journal of Biochemistry, vol.267, issue.14, pp.4339-4345, 2000.

S. Grenklo, A crucial role for profilin-actin in the intracellular motility of Listeria monocytogenes, EMBO reports, vol.4, issue.5, pp.523-532, 2003.

F. Gros-louis, Mutations in SYNE1 lead to a newly discovered form of autosomal recessive cerebellar ataxia, Nature genetics, vol.39, issue.1, pp.80-85, 2007.

G. R. Grotendorst, H. Okochi, and N. Hayashi, A novel transforming growth factor beta response element controls the expression of the connective tissue growth factor gene, Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research, vol.7, issue.4, pp.469-80, 1996.

Y. Gruenbaum and R. Foisner, Lamins: Nuclear Intermediate Filament Proteins with Fundamental Functions in Nuclear Mechanics and Genome Regulation, Annual Review of Biochemistry, vol.84, issue.1, pp.131-164, 2015.

E. T. Grygielko, Inhibition of gene markers of fibrosis with a novel inhibitor of transforming growth factor-beta type I receptor kinase in puromycin-induced nephritis, The Journal of pharmacology and experimental therapeutics, vol.313, issue.3, pp.943-51, 2005.

L. Guelen, Domain organization of human chromosomes revealed by mapping of nuclear lamina interactions, Nature, vol.453, issue.7197, pp.948-51, 2008.

C. Guilluy, Isolated nuclei adapt to force and reveal a mechanotransduction pathway in the nucleus, Nature cell biology, vol.16, issue.4, pp.376-81, 2014.

C. B. Gurniak, E. Perlas, and W. Witke, The actin depolymerizing factor n-cofilin is essential for neural tube morphogenesis and neural crest cell migration, Developmental biology, vol.278, issue.1, pp.231-272, 2005.

H. Hanafusa, Involvement of the p38 Mitogen-activated Protein Kinase Pathway in Transforming Growth Factor-induced Gene Expression, Journal of Biological Chemistry, vol.274, issue.38, pp.27161-27167, 1999.

F. Haque, Mammalian SUN protein interaction networks at the inner nuclear membrane and their role in laminopathy disease processes, The Journal of biological chemistry, vol.285, issue.5, pp.3487-98, 2010.

F. Haque, SUN1 interacts with nuclear lamin A and cytoplasmic nesprins to provide a physical connection between the nuclear lamina and the cytoskeleton, Molecular and cellular biology, vol.26, issue.10, pp.3738-51, 2006.

C. A. Harris, Structure and mapping of the human thymopoietin (TMPO) gene and relationship of human TMPO beta to rat lamin-associated polypeptide 2, Genomics, vol.28, issue.2, pp.198-205, 1995.

M. C. Hart and J. A. Cooper, Vertebrate isoforms of actin capping protein ?? have distinct functions in vivo, Journal of Cell Biology, vol.147, issue.6, pp.1287-1298, 1999.

M. T. Hartsough and K. M. Mulder, Transforming growth factor ?? activation of p44mapk in proliferating cultures of epithelial cells, Journal of Biological Chemistry, vol.270, issue.13, pp.7117-7124, 1995.

F. Hasebe-kishi and Y. Shimada, Dynamics of actin and a-actinin in nascent myo ® brils and stress ® bers, Cell Motility, pp.717-724, 2001.

M. Hawkins, Human actin depolymerizing factor mediates a pH-sensitive destruction of actin filaments, Biochemistry, vol.32, issue.38, pp.9985-9993, 1993.

T. Hayashida, TGF-beta1 activates MAP kinase in human mesangial cells: a possible role in collagen expression, Kidney international, vol.56, issue.5, pp.1710-1730, 1999.

S. M. Hayden, Analysis of the interactions of actin depolymerizing factor with G-and F-actin, Biochemistry, vol.32, issue.38, pp.9994-10004, 1993.

R. Heald and F. Mckeon, Mutations of phosphorylation sites in lamin A that prevent nuclear lamina disassembly in mitosis, Cell, vol.61, issue.4, pp.579-589, 1990.

E. Heitlinger, Expression of Chicken Lamin B2 in, Cell, vol.113, issue.3, pp.485-495, 1991.

C. H. Heldin, K. Miyazono, and P. Ten-dijke, TGF-beta signalling from cell membrane to nucleus through SMAD proteins, Nature, vol.390, issue.6659, pp.465-71, 1997.

E. Helfer, Mammalian twinfilin sequesters ADP-G-actin and caps filament barbed ends: implications in motility, The EMBO journal, vol.25, issue.6, pp.1184-95, 2006.
URL : https://hal.archives-ouvertes.fr/hal-01960873

H. N. Higgs, Formin proteins: A domain-based approach, Trends in Biochemical Sciences, vol.30, issue.6, pp.342-353, 2005.

H. N. Higgs and K. J. Peterson, Phylogenetic analysis of the formin homology 2 domain, Molecular biology of the cell, vol.16, issue.8, pp.1-13, 2005.

M. D. Hjelmeland, SB-431542, a small molecule transforming growth factor-{beta}-receptor antagonist, inhibits human glioma cell line proliferation and motility, Mol. Cancer Ther, vol.3, issue.6, pp.737-745, 2004.

C. Y. Ho, Lamin A/C and emerin regulate MKL1-SRF activity by modulating actin dynamics, Nature, vol.497, issue.7450, pp.507-518, 2013.

B. Hocevar, T. L. Brown, and P. H. Howe, TGF-beta induces fibronectin synthesis through a c-Jun N-terminal kinase-dependent, Smad4-independent pathway, The EMBO journal, vol.18, issue.5, pp.1345-56, 1999.

B. A. Hocevar and P. H. Howe, Analysis of TGF-beta-mediated synthesis of extracellular matrix components, Methods in molecular biology, vol.142, pp.55-65, 2000.

D. M. Hodzic, Sun2 is a novel mammalian inner nuclear membrane protein, Journal of Biological Chemistry, vol.279, issue.24, pp.25805-25812, 2004.

K. Hoffmann, Mutations in the gene encoding the lamin B receptor produce an altered nuclear morphology in granulocytes (Pelger-Huët anomaly), Nature Genetics, vol.31, issue.4, pp.410-414, 2002.

T. H. Höger, Characterization of a second highly conserved B-type lamin present in cells previously thought to contain only a single B-type lamin, Chromosoma, issue.6, pp.379-390, 1990.

A. Holmes, CTGF and SMADs, maintenance of scleroderma phenotype is independent of SMAD signaling, The Journal of biological chemistry, vol.276, issue.14, pp.10594-601, 2001.

M. Hong, Non-Smad Transforming Growth Factor-Signaling Regulated by Focal Adhesion Kinase Binding the p85 Subunit of Phosphatidylinositol 3-Kinase, Journal of Biological Chemistry, vol.286, issue.20, pp.17841-17850, 2011.

D. Horbelt, A. Denkis, and P. Knaus, A portrait of Transforming Growth Factor ?? superfamily signalling: Background matters, International Journal of Biochemistry and Cell Biology, vol.44, issue.3, pp.469-474, 2012.

P. Hotulainen and P. Lappalainen, Stress fibers are generated by two distinct actin assembly mechanisms in motile cells, Journal of Cell Biology, vol.173, issue.3, pp.383-394, 2006.

F. Houben, Disturbed nuclear orientation and cellular migration in A-type lamin deficient cells, Biochimica et Biophysica Acta-Molecular Cell Research, vol.1793, issue.2, pp.312-324, 2009.

X. Hu, The role of ERK and JNK signaling in connective tissue growth factor induced extracellular matrix protein production and scar formation, Archives of dermatological research, vol.305, issue.5, pp.433-478, 2013.

J. I?zecka, Z. Stelmasiak, and B. Dobosz, Transforming Growth Factor-Beta 1 (Tgf-Beta 1) in Patients With Amyotrophic Lateral Sclerosis, Cytokine, vol.20, issue.5, pp.239-243, 2002.

K. Imanaka-yoshida, J. M. Sanger, and J. W. Sanger, Contractile protein dynamics of myofibrils in paired adult rat cardiomyocytes, Cell Motility and the Cytoskeleton, vol.26, issue.4, pp.301-312, 1993.

P. Isermann and J. Lammerding, Nuclear Mechanics and Mechanotransduction in Health and Disease, Current Biology, vol.23, issue.24, pp.1113-1121, 2013.
DOI : 10.1016/j.cub.2013.11.009

URL : https://doi.org/10.1016/j.cub.2013.11.009

T. Iskratsch, FHOD1 is needed for directed forces and adhesion maturation during cell spreading and migration, Developmental Cell, vol.27, issue.5, pp.545-559, 2013.
DOI : 10.1016/j.devcel.2013.11.003

URL : https://doi.org/10.1016/j.devcel.2013.11.003

D. Jahn, Dynamic properties of meiosis-specific lamin C2 and its impact on nuclear envelope integrity, Nucleus, vol.1, issue.3, pp.273-283, 2010.

S. Jansen, Single-molecule imaging of a three-component ordered actin disassembly mechanism, Nature Communications, vol.6, p.7202, 2015.
DOI : 10.1038/ncomms8202

URL : https://www.nature.com/articles/ncomms8202.pdf

D. Javelaud and A. Mauviel, Mammalian transforming growth factor-betas: Smad signaling and physiopathological roles, The international journal of biochemistry & cell biology, vol.36, issue.7, pp.1161-1166, 2004.
DOI : 10.1016/s1357-2725(03)00255-3

URL : https://hal.archives-ouvertes.fr/inserm-00147457

C. J. Jiang, A. G. Weeds, and P. J. Hussey, The maize actin-depolymerizing factor, ZmADF3, redistributes to the growing tip of elongating root hairs and can be induced to translocate into the nucleus with actin, The Plant journal : for cell and molecular biology, vol.12, issue.5, pp.1035-1043, 1997.

H. Kanaya, Fhos2, a novel formin-related actin-organizing protein, probably associates with the nestin intermediate filament, Genes to Cells, vol.10, issue.7, pp.665-678, 2005.

-. Kan and M. , Mammalian formin Fhod3 plays an essential role in cardiogenesis by organizing myofibrillogenesis, Biology open, vol.1, issue.9, pp.889-96, 2012.

S. Kärkkäinen, A novel mutation, Ser143Pro, in the lamin A/C gene is common in finnish patients with familial dilated cardiomyopathy, European heart journal, vol.25, issue.10, pp.885-93, 2004.

M. Katsuno, Disrupted transforming growth factor-beta signaling in spinal and bulbar muscular atrophy. The Journal of neuroscience : the official journal of the Society for Neuroscience, vol.30, pp.5702-5712, 2010.

G. Kayman-kurekci, Mutation in TOR1AIP1 encoding LAP1B in a form of muscular dystrophy: a novel gene related to nuclear envelopathies, Neuromuscular disorders : NMD, vol.24, issue.7, pp.624-657, 2014.

B. K. Kennedy and J. K. Pennypacker, RB and Lamins in Cell Cycle Regulation and Aging, pp.127-142, 2014.

E. Kerkhoff, Cellular functions of the Spir actin-nucleation factors, Trends in Cell Biology, vol.16, issue.9, pp.477-483, 2006.

M. Ketema, Requirements for the localization of nesprin-3 at the nuclear envelope and its interaction with plectin, Journal of cell science, vol.120, pp.3384-94, 2007.

N. Khalil and A. H. Greenberg, The role of TGF-beta in pulmonary fibrosis, Ciba Found Symp, vol.157, pp.111-194, 1991.

R. Khan and R. Sheppard, Fibrosis in heart disease: Understanding the role of transforming growth factor-??1 in cardiomyopathy, valvular disease and arrhythmia, Immunology, vol.118, issue.1, pp.10-24, 2006.

S. B. Khatau, A perinuclear actin cap regulates nuclear shape, Proceedings of the National Academy of Sciences of the United States of America, vol.106, pp.19017-19039, 2009.

Y. Kim, Mouse B-type lamins are required for proper organogenesis but not by embryonic stem cells, Science, issue.6063, pp.1706-1716, 2011.

Y. Kim, X. Zheng, and Y. Zheng, Proliferation and differentiation of mouse embryonic stem cells lacking all lamins, Cell research, vol.23, issue.12, pp.1420-1423, 2013.

S. M. Klauck, Identification of novel mutations in three families with Emery-Dreifuss muscular dystrophy, Hum Mol Genet, vol.4, issue.10, pp.1853-1857, 1995.

G. Klein, Increased collagen deposition and diastolic dysfunction but preserved myocardial hypertrophy after pressure overload in mice lacking PKC??, Circulation Research, vol.96, issue.7, pp.748-755, 2005.

R. Knöll, The cardiac mechanical stretch sensor machinery involves a Z disc complex that is defective in a subset of human dilated cardiomyopathy, Cell, vol.111, issue.7, pp.943-55, 2002.

M. Komiyama, Dynamics of actin and assembly of connectin (titin) during myofibrillogenesis in embryonic chick cardiac muscle cells in vitro. Developmental dynamics : an official publication of the, vol.196, pp.291-299, 1993.

V. Kooij, Profilin Modulates Sarcomeric Organization and Mediates Cardiomyocyte Hypertrophy, pp.1-35, 2016.

H. Kosako, Xenopus MAP kinase activator is a serine/threonine/tyrosine kinase activated by threonine phosphorylation, The EMBO journal, vol.11, issue.8, pp.2903-2911, 1992.

Y. E. Koshman, Connective tissue growth factor regulates cardiac function and tissue remodeling in a mouse model of dilated cardiomyopathy, Journal of Molecular and Cellular Cardiology, vol.89, pp.214-222, 2015.

Y. E. Koshman, Regulation of connective tissue growth factor gene expression and fibrosis in human heart failure, Journal of cardiac failure, vol.19, issue.4, pp.283-94, 2013.

E. Kovalenko, Validation of connective tissue growth factor (CTGF/CCN2) and its gene polymorphisms as noninvasive biomarkers for the assessment of liver fibrosis, Journal of viral hepatitis, vol.16, issue.9, pp.612-632, 2009.

R. Kozma, The Ras-related protein Cdc42Hs and bradykinin promote formation of peripheral actin microspikes and filopodia in Swiss 3T3 fibroblasts, Molecular and Cellular Biology, vol.15, issue.4, pp.1942-1952, 1995.

E. Kremneva, Cofilin-2 controls actin filament length in muscle sarcomeres, Developmental cell, vol.31, issue.2, pp.215-241, 2014.
URL : https://hal.archives-ouvertes.fr/hal-01140881

M. Kretzschmar, A mechanism of repression of TGFbeta/ Smad signaling by oncogenic Ras, Genes & development, vol.13, issue.7, pp.804-820, 1999.

M. Kretzschmar, J. Doody, and J. Massagué, Opposing BMP and EGF signalling pathways converge on the TGF-beta family mediator Smad1, Nature, vol.389, issue.6651, pp.618-640, 1997.

M. Kretzschmar and J. Massagué, SMADs: mediators and regulators of TGF-? signaling, Current Opinion in Genetics & Development, vol.8, issue.1, pp.103-111, 1998.

I. Krieger, Crystal structure of the C-terminal half of tropomodulin and structural basis of actin filament pointed-end capping, Biophysical journal, vol.83, issue.5, pp.2716-2725, 2002.

I. Krimm, The Ig-like structure of the C-terminal domain of lamin A/C, mutated in muscular dystrophies, cardiomyopathy, and partial lipodystrophy, Structure, vol.10, issue.6, pp.811-823, 2002.

G. Krohne and R. Benavente, The nuclear lamins: A multigene family of proteins in evolution and differentiation, Experimental Cell Research, vol.162, issue.1, pp.1-10, 1986.

U. Kucich, Signaling events required for transforming growth factor-beta stimulation of connective tissue growth factor expression by cultured human lung fibroblasts, Archives of biochemistry and biophysics, vol.395, issue.1, pp.103-115, 2001.

F. Kuwahara, Transforming growth factor-?? function blocking prevents myocardial fibrosis and diastolic dysfunction in pressure-overloaded rats, Circulation, vol.106, issue.1, pp.130-135, 2002.

C. F. Lai, Erk is essential for growth, differentiation, integrin expression, and cell function in human osteoblastic cells, The Journal of biological chemistry, vol.276, issue.17, pp.14443-50, 2001.

N. G. Laing, Congenital myopathies, Current opinion in neurology, vol.20, issue.5, pp.583-592, 2007.

J. Lammerding, Lamin A/C deficiency causes defective nuclear mechanics and mechanotransduction, The Journal of clinical investigation, vol.113, issue.3, pp.370-378, 2004.

J. Lammerding, Lamins A and C but Not Lamin B1 Regulate Nuclear Mechanics, Journal of Biological Chemistry, vol.281, issue.35, pp.25768-25780, 2006.

H. Y. Lan, Diverse roles of TGF-?/Smads in renal fibrosis and inflammation, International journal of biological sciences, vol.7, issue.7, pp.1056-67, 2011.

T. Lanzicher, The Cardiomyopathy Lamin A/C D192G Mutation Disrupts Whole-Cell Biomechanics in Cardiomyocytes as Measured by Atomic Force Microscopy Loading-Unloading Curve, Analysis. Scientific reports, vol.5, p.13388, 2015.

N. J. Laping, Inhibition of Transforming Growth Factor (TGF)-beta 1-Induced Extracellular Matrix with a Novel Inhibitor of the TGF-beta Type I Receptor Kinase Activity: SB-431542, Molecular Pharmacology, vol.62, issue.1, pp.58-64, 2002.

A. Leask, Connective tissue growth factor gene regulation. Requirements for its induction by transforming growth factor-beta 2 in fibroblasts, The Journal of biological chemistry, vol.278, issue.15, pp.13008-13023, 2003.
DOI : 10.1074/jbc.m210366200

URL : http://www.jbc.org/content/278/15/13008.full.pdf

A. Leask and D. J. Abraham, TGF-beta signaling and the fibrotic response, FASEB journal : official publication of the Federation of American Societies for Experimental Biology, vol.18, issue.7, pp.816-843, 2004.

J. S. Lee, Nuclear lamin A/C deficiency induces defects in cell mechanics, polarization, and migration, Biophysical journal, vol.93, issue.7, pp.2542-52, 2007.
DOI : 10.1529/biophysj.106.102426

URL : https://doi.org/10.1529/biophysj.106.102426

K. K. Lee, Distinct functional domains in emerin bind lamin A and DNA-bridging protein BAF, J. Cell Sci, vol.114, issue.24, pp.4567-4573, 2001.

M. K. Lee, TGF-beta activates Erk MAP kinase signalling through direct phosphorylation of ShcA, The EMBO journal, vol.26, issue.17, pp.3957-67, 2007.

S. T. Lee-hoeflich, Activation of LIMK1 by binding to the BMP receptor, BMPRII, regulates BMPdependent dendritogenesis, The EMBO journal, vol.23, issue.24, pp.4792-801, 2004.

S. Leivonen, Smad3 and extracellular signal-regulated kinase 1/2 coordinately mediate transforming growth factor-beta-induced expression of connective tissue growth factor in human fibroblasts, The Journal of investigative dermatology, vol.124, issue.6, pp.1162-1171, 2005.

L. Roy, C. Wrana, and J. L. , Clathrin-and non clathrin-mediated endocytic regulation of cell signaling, Nat Rev Mol Cell Biol, vol.3, pp.615-623, 2005.

Y. Li, Transforming growth factor-beta1 induces the differentiation of myogenic cells into fibrotic cells in injured skeletal muscle: a key event in muscle fibrogenesis, The American journal of pathology, vol.164, issue.3, pp.1007-1026, 2004.

P. J. Lijnen, V. Petrov, and R. H. Fagard, Induction of cardiac fibrosis by transforming growth factor-beta(1). Molecular genetics and metabolism, vol.71, pp.418-453, 2000.
DOI : 10.1006/mgme.2000.3032

F. Lin, MAN1, an integral protein of the inner nuclear membrane, binds Smad2 and Smad3 and antagonizes transforming growth factor-? signaling, Human Molecular Genetics, vol.14, issue.3, pp.437-445, 2005.
DOI : 10.1093/hmg/ddi040

URL : https://academic.oup.com/hmg/article-pdf/14/3/437/2235491/ddi040.pdf

F. Lin and H. J. Worman, Expression of nuclear lamins in human tissues and cancer cell lines and transcription from the promoters of the lamin A/C and B1 genes, Experimental cell research, vol.236, issue.2, pp.378-84, 1997.

F. Lin and H. J. Worman, Structural organization of the human gene encoding nuclear lamin A and nuclear lamin C, Journal of Biological Chemistry, vol.268, issue.22, pp.16321-16326, 1993.

Y. Lin, Serum transforming growth factor-beta1 levels and pancreatic cancer risk: a nested case-control study (Japan), Cancer causes & control : CCC, vol.17, issue.8, pp.1077-1082, 2006.
DOI : 10.1007/s10552-006-0048-0

R. Littlefield, . Almenar-queralt, and V. M. Fowler, Actin dynamics at pointed ends regulates thin filament length in striated muscle, Nature cell biology, vol.3, issue.6, pp.544-551, 2001.
DOI : 10.1038/35078517

G. Liu, Recapitulation of premature ageing with iPSCs from Hutchinson-Gilford progeria syndrome, Nature, issue.7342, pp.221-226, 2011.
DOI : 10.1038/nature09879

URL : http://europepmc.org/articles/pmc3088088?pdf=render

J. Liu, Essential Roles for Caenorhabditis elegans Lamin Gene in Nuclear Organization, Cell Cycle Progression, and Spatial Organization of Nuclear Pore Complexes, Molecular Biology of the Cell, vol.11, issue.11, pp.3937-3947, 2000.

X. Liu, H. Hu, and J. Q. Yin, Therapeutic strategies against TGF-beta signaling pathway in hepatic fibrosis, Liver International, vol.26, issue.1, pp.8-22, 2006.
DOI : 10.1111/j.1478-3231.2005.01192.x

A. D. Liverman, Arp2/3-independent assembly of actin by Vibrio type III effector VopL, Proceedings of the National Academy of Sciences of the United States of America, vol.104, pp.17117-17122, 2007.

D. J. Lloyd, A novel interaction between lamin A and SREBP1: implications for partial lipodystrophy and other laminopathies, Human Molecular Genetics, vol.11, issue.7, pp.769-777, 2002.

L. Loewinger and F. Mckeon, Mutations in the nuclear lamin proteins resulting in their aberrant assembly in the cytoplasm, The EMBO journal, vol.7, issue.8, pp.2301-2309, 1988.

T. P. Loisel, Reconstitution of actin-based motility of Listeria and Shigella using pure proteins, Nature, vol.401, issue.6753, pp.613-616, 1999.

M. L. Lombardi, The interaction between nesprins and sun proteins at the nuclear envelope is critical for force transmission between the nucleus and cytoskeleton, Journal of Biological Chemistry, issue.30, p.286, 2011.

J. T. Lu, LMNA cardiomyopathy: cell biology and genetics meet clinical medicine, Disease models & mechanisms, vol.4, issue.5, pp.562-570, 2011.

Y. C. Lussi, The nucleoporin Nup88 is interacting with nuclear lamin A, Molecular biology of the cell, vol.22, issue.7, pp.1080-90, 2011.

G. W. Luxton, Linear arrays of nuclear envelope proteins harness retrograde actin flow for nuclear movement, Science, issue.5994, pp.956-965, 2010.

G. W. Luxton, TAN lines: a novel nuclear envelope structure involved in nuclear positioning, Nucleus (Austin, Tex.), vol.2, issue.3, pp.173-81, 2011.

B. M. Machiels, An alternative splicing product of the lamin A/C gene lacks exon 10, The Journal of biological chemistry, vol.271, issue.16, pp.9249-53, 1996.

S. K. Maciver, H. G. Zot, and T. D. Pollard, Characterization of actin filament severing by actophorin from Acanthamoeba castellanii, Journal of Cell Biology, vol.115, issue.6, pp.1611-1620, 1991.

A. H. Madrid, Use of irbesartan to maintain sinus rhythm in patients with long-lasting persistent atrial fibrillation: A prospective and randomized study, Circulation, vol.106, issue.3, pp.331-336, 2002.

M. A. Mancini, The retinoblastoma gene product is a cell cycle-dependent, nuclear matrix-associated protein, Proceedings of the National Academy of Sciences of the United States of America, vol.91, pp.418-440, 1994.

M. Mansharamani and K. L. Wilson, Direct binding of nuclear membrane protein MAN1 to emerin in vitro and two modes of binding to barrier-to-autointegration factor, The Journal of biological chemistry, vol.280, issue.14, pp.13863-70, 2005.

M. Mardahl-dumesnil and V. M. Fowler, Thin filaments elongate from their pointed ends during myofibril assembly in Drosophila indirect flight muscle, Journal of Cell Biology, vol.155, issue.6, pp.1043-1053, 2001.

I. Mariappan, Identification of cyclin D3 as a new interaction partner of lamin A/C. Biochemical and biophysical research communications, vol.355, pp.981-986, 2007.

E. Markiewicz, Lamin A/C Binding Protein LAP2alpha Is Required for Nuclear Anchorage of Retinoblastoma Protein, Molecular Biology of the Cell, vol.13, issue.12, pp.4401-4413, 2002.

E. Markiewicz, M. Ledran, and C. J. Hutchison, Remodelling of the nuclear lamina and nucleoskeleton is required for skeletal muscle differentiation in vitro, Journal of cell science, vol.118, pp.409-429, 2005.

A. M. Martelli, Molecular characterization of protein kinase C-alpha binding to lamin A, Journal of cellular biochemistry, vol.86, issue.2, pp.320-350, 2002.

L. Martin, C. Crimaudo, and L. Gerace, cDNA cloning and characterization of lamina-associated polypeptide 1C (LAP1C), an integral protein of the inner nuclear membrane, Journal of Biological Chemistry, vol.270, issue.15, pp.8822-8828, 1995.

S. B. Martins, HA95 is a protein of the chromatin and nuclear matrix regulating nuclear envelope dynamics, Journal of cell science, pp.3703-3713, 2000.

C. P. Maske, A carboxyl-terminal interaction of lamin B1 is dependent on the CAAX endoprotease Rce1 and carboxymethylation, Journal of Cell Biology, vol.162, issue.7, pp.1223-1232, 2003.

J. Massagué, A very private TGF-beta receptor embrace, Molecular cell, vol.29, issue.2, pp.149-50, 2008.

J. Massagué, TGFbeta in Cancer. Cell, vol.134, issue.2, pp.215-245, 2008.

J. Massagué, TGF-beta signal transduction. Annual review of biochemistry, vol.67, pp.753-91, 1998.

J. Massagué, The transforming growth factor-beta family, Annual review of cell biology, vol.6, pp.597-641, 1990.

J. Massague and Y. Chen, Controlling TGF-beta signaling, Genes & Dev, vol.14, issue.6, pp.627-644, 2000.

I. Matsuura, C. Lai, and K. Chiang, Functional interaction between Smad3 and S100A4 (metastatin-1) for TGF-beta-mediated cancer cell invasiveness, The Biochemical journal, vol.426, issue.3, pp.327-362, 2010.
DOI : 10.1042/bj20090990

P. K. Mattila and P. Lappalainen, Filopodia: molecular architecture and cellular functions, Nature reviews. Molecular cell biology, vol.9, issue.6, pp.446-454, 2008.
DOI : 10.1038/nrm2406

. Mcgough and W. Chiu, ADF/cofilin weakens lateral contacts in the actin filament, Journal of molecular biology, vol.291, issue.3, pp.513-522, 1999.

A. Mcgough, Cofilin changes the twist of F-actin: Implications for actin filament dynamics and cellular function, Journal of Cell Biology, vol.138, issue.4, pp.771-781, 1997.

F. D. Mckeon, M. W. Kirschner, and D. Caput, Homologies in both primary and secondary structure between nuclear envelope and intermediate filament proteins, Nature, issue.6053, pp.463-468, 1986.

E. M. Mcnally, J. R. Golbus, and M. J. Puckelwartz, Genetic mutations and mechanisms in dilated cardiomyopathy, The Journal of Clinical Investigation, vol.123, issue.1, pp.19-26, 2013.

J. A. Mellad, D. T. Warren, and C. M. Shanahan, Nesprins LINC the nucleus and cytoskeleton. Current opinion in cell biology, vol.23, pp.47-54, 2011.
DOI : 10.1016/j.ceb.2010.11.006

C. Meune, Primary Prevention of Sudden Death in Patients with Lamin A/C Gene Mutations, New England Journal of Medicine, vol.354, issue.2, pp.209-210, 2006.

L. Mi-mi and D. Pruyne, Loss of Sarcomere-associated Formins Disrupts Z-line Organization, but does not Prevent Thin Filament Assembly in Caenorhabditis elegans Muscle, Journal of cytology & histology, vol.6, issue.2, 2015.

J. M. Mislow, Nesprin-1? self-associates and binds directly to emerin and lamin A in vitro, FEBS Letters, vol.525, issue.1-3, pp.135-140, 2002.

J. M. Mislow, Myne-1, a spectrin repeat transmembrane protein of the myocyte inner nuclear membrane, interacts with lamin A/C, J. Cell Sci, vol.115, issue.1, pp.61-70, 2002.

D. G. Moerman and A. Fire, Muscle: Structure, Function, and Development. Cold Spring Harbor Monograph Archive, vol.16, pp.417-470, 1997.

M. Mogi, Transforming growth factor-?1 levels are elevated in the striatum and in ventricular cerebrospinal fluid in Parkinson's disease, Neuroscience Letters, vol.193, issue.2, pp.129-132, 1995.

R. D. Moir, Nuclear Lamins a and B1, The Journal of Cell Biology, vol.151, issue.6, pp.1155-1168, 2000.
DOI : 10.1083/jcb.151.6.1155

URL : http://jcb.rupress.org/content/151/6/1155.full.pdf

A. Molloy, A patient with a rare leukodystrophy related to lamin B1 duplication, Irish medical journal, vol.105, issue.6, pp.186-193, 2012.

M. G. Morales, Reducing CTGF/CCN2 slows down mdx muscle dystrophy and improves cell therapy, Human molecular genetics, vol.22, issue.24, pp.4938-51, 2013.

T. E. Morgan, Isolation and characterization of a regulated form of actin depolymerizing factor, Journal of Cell Biology, vol.122, issue.3, pp.623-633, 1993.

K. Moriyama, K. Iida, and I. Yahara, Phosphorylation of Ser-3 of cofilin regulates its essential function on actin, Genes Cells, vol.1, issue.1, pp.73-86, 1996.

K. Moriyama and I. Yahara, Two activities of cofilin, severing and accelerating directional depolymerization of actin filaments, are affected differentially by mutations around the actin-binding helix, The EMBO journal, vol.18, issue.23, pp.6752-61, 1999.

J. C. Morris, Phase I study of GC1008 (fresolimumab): a human anti-transforming growth factor-beta (TGF?) monoclonal antibody in patients with advanced malignant melanoma or renal cell carcinoma, PloS one, vol.9, issue.3, p.90353, 2014.

L. C. Mounkes, Expression of an LMNA-N195K variant of A-type lamins results in cardiac conduction defects and death in mice, Human Molecular Genetics, vol.14, issue.15, pp.2167-2180, 2005.

. Muchir, Identification of mutations in the gene encoding lamins A/C in autosomal dominant limb girdle muscular dystrophy with atrioventricular conduction disturbances (LGMD1B), Human molecular genetics, vol.9, issue.9, pp.1453-1459, 2000.

A. Muchir, P. Pavlidis, and G. Bonne, Activation of MAPK in hearts of EMD null mice: Similarities between mouse models of X-linked and autosomal dominant Emery-Dreifuss muscular dystrophy, Human Molecular Genetics, vol.16, issue.15, pp.1884-1895, 2007.

A. Muchir, P. Pavlidis, and V. Decostre, Activation of MAPK pathways links LMNA mutations to cardiomyopathy in Emery-Dreifuss muscular dystrophy, The Journal of clinical investigation, vol.117, issue.5, pp.1282-93, 2007.

A. Muchir, Inhibition of extracellular signal-regulated kinase signaling to prevent cardiomyopathy caused by mutation in the gene encoding A-type lamins, Human Molecular Genetics, vol.18, issue.2, pp.241-247, 2009.

A. Muchir, Mitogen-activated protein kinase kinase 1/2 inhibition and angiotensin II converting inhibition in mice with cardiomyopathy caused by lamin A/C gene mutation, Biochemical and Biophysical Research Communications, vol.452, issue.4, pp.958-961, 2014.

A. Muchir, Nuclear envelope alterations in fibroblasts from LGMD1B patients carrying nonsense Y259X heterozygous or homozygous mutation in lamin A/C gene, Experimental cell research, vol.291, issue.2, pp.352-62, 2003.

A. Muchir, Treatment with selumetinib preserves cardiac function and improves survival in cardiomyopathy caused by mutation in the lamin A/C gene, Cardiovascular Research, vol.93, issue.2, pp.311-319, 2012.

A. Muchir, W. Wu, and H. J. Worman, Mitogen-Activated Protein Kinase Inhibitor Regulation of Heart Function and Fibrosis in Cardiomyopathy Caused by Lamin A/C Gene Mutation, Trends in Cardiovascular Medicine, vol.20, issue.7, pp.217-221, 2010.

I. Mucsi, K. L. Skorecki, and H. J. Goldberg, Extracellular signal-regulated kinase and the small GTP-binding protein, Rac, contribute to the effects of transforming growth factor-beta1 on gene expression, J Biol Chem, vol.271, issue.28, pp.16567-16572, 1996.

R. E. Mudry, The interaction of tropomodulin with tropomyosin stabilizes thin filaments in cardiac myocytes, Journal of Cell Biology, vol.162, issue.6, pp.1057-1068, 2003.

S. Mumm, Deactivating germline mutations in LEMD3 cause osteopoikilosis and Buschke-Ollendorff syndrome, but not sporadic melorheostosis, J Bone Miner Res, vol.22, issue.2, pp.243-250, 2007.

S. Münter, Actin polymerisation at the cytoplasmic face of eukaryotic nuclei, BMC cell biology, vol.7, p.23, 2006.

J. E. Murphy-ullrich and M. Poczatek, Activation of latent TGF-beta by thrombospondin-1: mechanisms and physiology, Cytokine & growth factor reviews, vol.11, issue.1-2, pp.59-69, 2000.

A. Nagano, Emerin deficiency at the nuclear membrane in patients with Emery-Dreifuss muscular dystrophy, Nature genetics, vol.12, issue.3, pp.254-263, 1996.

R. Nagaoka, Concentration of cofilin, a small actin-binding protein, at the cleavage furrow during cytokinesis, Cell Motility and the Cytoskeleton, vol.30, issue.1, pp.1-7, 1995.

K. Nakano, Cofilin phosphorylation and actin polymerization by NRK/NESK, a member of the germinal center kinase family, Experimental Cell Research, vol.287, issue.2, pp.219-227, 2003.

S. S. Nakerakanti, A. M. Bujor, and M. Trojanowska, CCN2 is required for the TGF-? induced activation of Smad1-Erk1/2 signaling network, PloS one, vol.6, issue.7, p.21911, 2011.

C. L. Navarro, Lamin A and ZMPSTE24 (FACE-1) defects cause nuclear disorganization and identify restrictive dermopathy as a lethal neonatal laminopathy, Human molecular genetics, vol.13, issue.20, pp.2493-503, 2004.
URL : https://hal.archives-ouvertes.fr/hal-01668977

J. Nemunaitis, Phase II trial of Belagenpumatucel-L, a TGF-beta2 antisense gene modified allogeneic tumor vaccine in advanced non small cell lung cancer (NSCLC) patients, Cancer gene therapy, vol.16, issue.8, pp.620-624, 2009.

K. X. Ngo, Cofilin-induced unidirectional cooperative conformational changes in actin filaments revealed by high-speed atomic force microscopy, 2015.

E. Nigg, Assembly-disassembly of the nuclear lamina. Current opinion in cell biology, vol.4, pp.105-109, 1992.

V. Nigro, SSCP detection of novel mutations in patients with emery-dreifuss muscular dystrophy: Definition of a small c-terminal region required for emerin function, Human Molecular Genetics, vol.4, issue.10, pp.2003-2004, 1995.

V. Nikolova, and function promote dilated cardiomyopathy in lamin A / C-deficient mice, Journal of Clinical Investigation, vol.113, issue.3, pp.357-369, 2004.

V. Nikolova-krstevski, Nesprin-1 and actin contribute to nuclear and cytoskeletal defects in lamin A/Cdeficient cardiomyopathy, Journal of molecular and cellular cardiology, vol.50, issue.3, pp.479-86, 2011.

E. Nishida, Opposite effects of cofilin and profilin from porcine brain on rate of exchange of actin-bound adenosine 5'-triphosphate, Biochemistry, vol.24, issue.5, pp.1160-1164, 1985.

E. Nishida, S. Maekawa, and H. Sakai, Cofilin, a protein in porcine brain that binds to actin filaments and inhibits their interactions with myosin and tropomyosin, Biochemistry, vol.23, issue.22, pp.5307-5313, 1984.

G. A. Nusco, Modulation of calcium signalling by the actin-binding protein cofilin, Biochemical and biophysical research communications, vol.348, issue.1, pp.109-123, 2006.

H. Ohnishi, Increased expression of connective tissue growth factor in the infarct zone of experimentally induced myocardial infarction in rats, Journal of molecular and cellular cardiology, vol.30, issue.11, pp.2411-2433, 1998.

K. Okada, Adenomatous polyposis coli protein nucleates actin assembly and synergizes with the formin mDia1, Journal of Cell Biology, vol.189, issue.7, pp.1087-1096, 2010.

K. Okada, Xenopus actin-interacting protein 1 (XAip1) enhances cofilin fragmentation of filaments by capping filament ends, Journal of Biological Chemistry, vol.277, issue.45, pp.43011-43016, 2002.

J. Olivares, Phase I trial of TGF-?2 antisense GM-CSF gene-modified autologous tumor cell (TAG) vaccine, Clinical Cancer Research, vol.17, issue.1, pp.183-192, 2011.

K. Ono, Specific requirement for two ADF/cofilin isoforms in distinct actin-dependent processes in Caenorhabditis elegans, Journal of cell science, vol.116, pp.2073-85, 2003.

S. Ono, Characterization of a novel cofilin isoform that is predominantly expressed in mammalian skeletal muscle, Journal of Biological Chemistry, vol.269, issue.21, pp.15280-15286, 1994.

S. Ono, The C-terminal tail of UNC-60B (actin depolymerizing factor/cofilin) is critical for maintaining its stable association with F-actin and is implicated in the second actin-binding site, The Journal of biological chemistry, vol.276, issue.8, pp.5952-5960, 2001.

S. Ono, D. L. Baillie, and G. M. Benian, UNC-60B, an ADF cofilin family protein, is required for proper assembly of actin into myofibrils in Caenorhabditis elgans body wall muscle, Journal of Cell Biology, vol.145, issue.3, pp.491-502, 1999.

S. Ono, K. Mohri, and K. Ono, Microscopic Evidence That Actin-interacting Protein 1 Actively Disassembles Actin-depolymerizing Factor/Cofilin-bound Actin Filaments, Journal of Biological Chemistry, vol.279, issue.14, pp.14207-14212, 2004.

S. Ono and K. Ono, Tropomyosin inhibits ADF/cofilin-dependent actin filament dynamics, The Journal of cell biology, vol.156, issue.6, pp.1065-76, 2002.

S. Osada, XMAN1, an inner nuclear membrane protein, antagonizes BMP signaling by interacting with Smad1 in Xenopus embryos, Development, vol.130, issue.9, pp.1783-1794, 2003.

M. Oser, Cortactin regulates cofilin and N-WASp activities to control the stages of invadopodium assembly and maturation, Journal of Cell Biology, vol.186, issue.4, pp.571-587, 2009.

C. Ostlund, Properties of lamin A mutants found in Emery-Dreifuss muscular dystrophy, cardiomyopathy and Dunnigan-type partial lipodystrophy, J. Cell Sci, vol.114, issue.24, pp.4435-4445, 2001.

T. Ozaki, Complex formation between lamin A and the retinoblastoma gene product: identification of the domain on lamin A required for its interaction, Oncogene, vol.9, issue.9, pp.2649-53, 1994.

Q. S. Padiath, Lamin B1 duplications cause autosomal dominant leukodystrophy, Nature genetics, vol.38, issue.10, pp.1114-1137, 2006.

V. C. Padmakumar, Enaptin, a giant actin-binding protein, is an element of the nuclear membrane and the actin cytoskeleton, Experimental cell research, vol.295, issue.2, pp.330-339, 2004.

V. C. Padmakumar, The inner nuclear membrane protein Sun1 mediates the anchorage of Nesprin-2 to the nuclear envelope, Journal of cell science, vol.118, pp.3419-3430, 2005.

D. Pan, The integral inner nuclear membrane protein MAN1 physically interacts with the R-Smad proteins to repress signaling by the transforming growth factor-{beta} superfamily of cytokines, The Journal of biological chemistry, vol.280, issue.16, pp.15992-6001, 2005.

L. H. Pan, Type II alveolar epithelial cells and interstitial fibroblasts express connective tissue growth factor in IPF, European Respiratory Journal, vol.17, issue.6, pp.1220-1227, 2001.

A. N. Panek, Connective tissue growth factor overexpression in cardiomyocytes promotes cardiac hypertrophy and protection against pressure overload, PloS one, vol.4, issue.8, p.6743, 2009.

D. Pantaloni and M. F. Carlier, How profilin promotes actin filament assembly in the presence of thymosin ??4, Cell, vol.75, issue.5, pp.1007-1014, 1993.

V. Papalouka, Muscle LIM protein interacts with cofilin 2 and regulates F-actin dynamics in cardiac and skeletal muscle, Molecular and cellular biology, vol.29, issue.22, pp.6046-58, 2009.

V. Paradis, Expression of connective tissue growth factor in experimental rat and human liver fibrosis, Hepatology, vol.30, issue.4, pp.968-976, 1999.

M. Paulin-levasseur, The MAN antigens are non-lamin constituents of the nuclear lamina in vertebrate cells, Chromosoma, vol.104, issue.5, pp.367-379, 1996.

M. Pauschinger, Dilated cardiomyopathy is associated with significant changes in collagen type I/III ratio, Circulation, issue.21, pp.2750-2756, 1999.

V. S. Peche, Ablation of cyclase-associated protein 2 (CAP2) leads to cardiomyopathy, Cellular and Molecular Life Sciences, vol.70, issue.3, pp.527-543, 2013.

O. D. Pedersen, Trandolapril reduces the incidence of atrial fibrillation after acute myocardial infarction in patients with left ventricular dysfunction, Circulation, vol.100, pp.376-380, 1999.

J. Peltonen, Increased expression of type VI collagen genes in systemic sclerosis, Arthritis and rheumatism, vol.33, pp.1829-1835, 1990.

A. M. Pendas, Defective prelamin A processing and muscular and adipocyte alterations in Zmpste24 metalloproteinase-deficient mice, Nat Genet, vol.31, issue.1, pp.94-99, 2002.

J. Perovanovic, Laminopathies disrupt epigenomic developmental programs and cell fate, Science translational medicine, vol.8, issue.335, pp.335-58, 2016.
DOI : 10.1126/scitranslmed.aad4991

URL : https://stm.sciencemag.org/content/scitransmed/8/335/335ra58.full.pdf

M. Peter, Cloning and sequencing of cDNA clones encoding chicken lamins A and B1 and comparison of the primary structures of vertebrate A-and B-type lamins, Journal of Molecular Biology, vol.208, issue.3, pp.393-404, 1989.

G. C. Pipes, E. E. Creemers, and E. N. Olson, The myocardin family of transcriptional coactivators: versatile regulators of cell growth, migration, and myogenesis, Genes & development, vol.20, issue.12, pp.1545-56, 2006.

D. Pohlers, TGF-? and fibrosis in different organs-molecular pathway imprints, Biochimica et Biophysica Acta-Molecular Basis of Disease, issue.8, pp.746-756, 2009.
URL : https://hal.archives-ouvertes.fr/hal-00506515

D. Polet, Caenorhabditis elegans expresses three functional profilins in a tissue-specific manner, Cell Motility and the Cytoskeleton, vol.63, issue.1, pp.14-28, 2006.

T. D. Pollard, Regulation of actin filament assembly by Arp2/3 complex and formins. Annual review of biophysics and biomolecular structure, vol.36, pp.451-477, 2007.

T. D. Pollard and G. G. Borisy, Cellular motility driven by assembly and disassembly of actin filaments, Cell, vol.112, issue.4, pp.453-465, 2003.
DOI : 10.1016/s0092-8674(03)00357-x

URL : https://doi.org/10.1016/s0092-8674(03)00357-x

M. Ponticos, Pivotal role of connective tissue growth factor in lung fibrosis: MAPK-dependent transcriptional activation of type I collagen, Arthritis and rheumatism, vol.60, issue.7, pp.2142-55, 2009.

B. J. Pope, Uncoupling actin filament fragmentation by cofilin from increased subunit turnover, Journal of molecular biology, vol.298, issue.4, pp.649-661, 2000.

E. Prochniewicz, Cofilin increases the torsional flexibility and dynamics of actin filaments, Journal of Molecular Biology, vol.353, issue.5, pp.990-1000, 2005.

D. Pruyne, Role of formins in actin assembly: nucleation and barbed-end association, Science, issue.5581, pp.612-617, 2002.

M. J. Puckelwartz, Disruption of nesprin-1 produces an Emery Dreifuss muscular dystrophy-like phenotype in mice, Human Molecular Genetics, vol.18, issue.4, pp.607-620, 2009.

S. Quijano-roy, De novo LMNA mutations cause a new form of congenital muscular dystrophy, Annals of Neurology, vol.64, issue.2, pp.177-186, 2008.

M. E. Quinlan, Drosophila Spire is an actin nucleation factor, Nature, issue.7024, pp.382-388, 2005.
DOI : 10.1038/nature03241

R. Di-barletta and M. , Different mutations in the LMNA gene cause autosomal dominant and autosomal recessive Emery-Dreifuss muscular dystrophy, American journal of human genetics, vol.66, issue.4, pp.1407-1419, 2000.

R. A. Rahimi and E. B. Leof, TGF-? signaling: A tale of two responses, Journal of Cellular Biochemistry, vol.102, issue.3, pp.593-608, 2007.

G. P. Raju, SANE, a novel LEM domain protein, regulates bone morphogenetic protein signaling through interaction with Smad1, The Journal of biological chemistry, vol.278, issue.1, pp.428-465, 2003.
DOI : 10.1074/jbc.m210505200

URL : http://www.jbc.org/content/278/1/428.full.pdf

F. J. Ramos, Rapamycin Reverses Elevated mTORC1 Signaling in Lamin A/C-Deficient Mice, Rescues Cardiac and Skeletal Muscle Function, and Extends Survival, Science Translational Medicine, vol.4, issue.144, pp.144-103, 2012.
DOI : 10.1126/scitranslmed.3003802

URL : http://europepmc.org/articles/pmc3613228?pdf=render

D. Razafsky and D. Hodzic, Bringing KASH under the SUN: The many faces of nucleo-cytoskeletal connections, Journal of Cell Biology, vol.186, issue.4, pp.461-472, 2009.

L. Renault, B. Bugyi, and M. F. Carlier, Spire and Cordon-bleu: multifunctional regulators of actin dynamics, Trends in Cell Biology, vol.18, issue.10, pp.494-504, 2008.

F. Ressad, Control of actin filament length and turnover by actin depolymerizing factor (ADF/cofilin) in the presence of capping proteins and ARP2/3 complex, Journal of Biological Chemistry, vol.274, issue.30, pp.20970-20976, 1999.

F. Ressad, Kinetic Analysis of the Interaction of Actin-depolymerizing Factor (ADF)/Cofilin with Gand F-Actins: COMPARISON OF PLANT AND HUMAN ADFs AND EFFECT OF PHOSPHORYLATION, Journal of Biological Chemistry, vol.273, issue.33, pp.20894-20902, 1998.

B. E. Richardson, S. J. Nowak, and M. K. Baylies, Myoblast fusion in fly and vertebrates: New genes, new processes and new perspectives, Traffic, vol.9, issue.7, pp.1050-1059, 2008.
DOI : 10.1111/j.1600-0854.2008.00756.x

URL : https://onlinelibrary.wiley.com/doi/pdf/10.1111/j.1600-0854.2008.00756.x

A. J. Ridley and A. Hall, The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors, Cell, vol.70, issue.3, pp.389-399, 1992.

D. B. Rifkin, APMIS : acta pathologica, microbiologica, et immunologica Scandinavica, vol.107, pp.80-85, 1999.

G. J. Riggins, Frequency of Smad gene mutations in human cancers, Cancer research, vol.57, pp.2578-2580, 1997.

L. Ritchey and R. Chakrabarti, Aurora A kinase modulates actin cytoskeleton through phosphorylation of Cofilin: Implication in the mitotic process, Biochimica et biophysica acta, issue.11, pp.2719-2748, 2014.

R. C. Robinson, Crystal structure of Arp2/3 complex, Science, vol.294, issue.5547, pp.1679-84, 2001.
DOI : 10.2210/pdb1k8k/pdb

K. Rochlin, Myoblast fusion: When it takes more to make one, Developmental Biology, vol.341, issue.1, pp.66-83, 2010.
DOI : 10.1016/j.ydbio.2009.10.024

URL : https://doi.org/10.1016/j.ydbio.2009.10.024

J. Rodríguez, ERK1/2 MAP kinases promote cell cycle entry by rapid, kinase-independent disruption of retinoblastoma-lamin A complexes, The Journal of cell biology, vol.191, issue.5, pp.967-79, 2010.

A. Rodrí-guez-barbero, Transforming growth factor-?1 induces collagen synthesis and accumulation via p38 mitogen-activated protein kinase (MAPK) pathway in cultured L 6 E 9 myoblasts, FEBS Letters, vol.513, issue.23, pp.282-288, 2002.

M. Rosado, Critical roles for multiple formins during cardiac myofibril development and repair, Molecular biology of the cell, vol.25, issue.6, pp.811-838, 2014.

S. Ross and C. S. Hill, How the Smads regulate transcription, The international journal of biochemistry & cell biology, vol.40, issue.3, pp.383-408, 2008.

K. J. Roux, Nesprin 4 is an outer nuclear membrane protein that can induce kinesin-mediated cell polarization, Proceedings of the National Academy of Sciences of the United States of America, vol.106, pp.2194-2199, 2009.

L. Rudnicka, Elevated expression of type VII collagen in the skin of patients with systemic sclerosis. Regulation by transforming growth factor-beta, The Journal of clinical investigation, vol.93, issue.4, pp.1709-1715, 1994.

M. Ruiz-ortega, TGF-beta signaling in vascular fibrosis, Cardiovascular research, vol.74, issue.2, pp.196-206, 2007.

A. E. Rusiñol and M. S. Sinensky, Farnesylated lamins, progeroid syndromes and farnesyl transferase inhibitors, Journal of cell science, vol.119, pp.3265-3272, 2006.

M. Sakaki, Interaction between Emerin and Nuclear Lamins, Journal of Biochemistry, vol.129, issue.2, pp.321-327, 2001.

A. Saltzman, Transforming growth factor-beta-mediated apoptosis in the Ramos B-lymphoma cell line is accompanied by caspase activation and Bcl-XL downregulation, Experimental cell research, vol.242, issue.1, pp.244-54, 1998.

D. Sandre-giovannoli and A. , Homozygous defects in LMNA, encoding lamin A/C nuclear-envelope proteins, cause autosomal recessive axonal neuropathy in human (Charcot-Marie-Tooth disorder type 2) and mouse, American journal of human genetics, vol.70, issue.3, pp.726-762, 2002.
URL : https://hal.archives-ouvertes.fr/hal-01724642

T. Sanna, Cardiac features of Emery-Dreifuss muscular dystrophy caused by lamin A/C gene mutations, European Heart Journal, vol.24, issue.24, pp.2227-2236, 2003.

Y. Sano, ATF-2 Is a Common Nuclear Target of Smad and TAK1 Pathways in Transforming Growth Factor-Signaling, Journal of Biological Chemistry, vol.274, issue.13, pp.8949-8957, 1999.

A. M. Sasseville and Y. Langelier, In vitro interaction of the carboxy-terminal domain of lamin A with actin, FEBS Letters, vol.425, issue.3, pp.485-489, 1998.

P. Scaffidi, Lamin A-Dependent Nuclear Defects in Human Aging, Science, issue.5776, pp.1059-1063, 2006.

A. Scherer and J. M. Graff, Calmodulin differentially modulates Smad1 and Smad2 signaling, Journal of Biological Chemistry, vol.275, issue.52, pp.41430-41438, 2000.

L. Schermelleh, Subdiffraction Multicolor Imaging of the Nuclear Periphery with 3D Structured Illumination Microscopy, Science, vol.320, issue.5881, pp.1332-1336, 2008.

. Schirenbeck, Formins and VASPs may co-operate in the formation of filopodia, Biochemical Society transactions, vol.33, pp.1256-1259, 2005.

M. Schoumacher, Actin, microtubules, and vimentin intermediate filaments cooperate for elongation of invadopodia, Journal of Cell Biology, vol.189, issue.3, pp.541-556, 2010.

K. H. Schreiber and B. K. Kennedy, When lamins go bad: nuclear structure and disease, Cell, vol.152, issue.6, pp.1365-75, 2013.

J. Schuster, Genomic duplications mediate overexpression of lamin B1 in adult-onset autosomal dominant leukodystrophy (ADLD) with autonomic symptoms, Neurogenetics, vol.12, issue.1, pp.65-72, 2011.

R. Seger, Purification and characterization of mitogen-activated protein kinase activator(s) from epidermal growth factor-stimulated A431 cells, The Journal of biological chemistry, vol.267, issue.20, pp.14373-81, 1992.

N. Senzer, Phase I trial of "bi-shRNAi(furin)/GMCSF DNA/autologous tumor cell" vaccine (FANG) in advanced cancer, Molecular therapy : the journal of the American Society of Gene Therapy, vol.20, issue.3, pp.679-86, 2012.

S. Shackleton, LMNA, encoding lamin A/C, is mutated in partial lipodystrophy, Nature genetics, vol.24, pp.153-156, 2000.

Y. Shi and J. Massagué, Mechanisms of TGF-? Signaling from Cell Membrane to the Nucleus, Cell, vol.113, issue.6, pp.685-700, 2003.

Y. Shima, Activation of caspase-8 in transforming growth factor-beta-induced apoptosis of human hepatoma cells, Hepatology, issue.5, pp.1215-1237, 1999.

T. Shimi and R. D. Goldman, Nuclear Lamins and Oxidative Stress in Cell Proliferation and Longevity, pp.415-430, 2014.

D. K. Shumaker, The highly conserved nuclear lamin Ig-fold binds to PCNA: its role in DNA replication, The Journal of cell biology, vol.181, issue.2, pp.269-80, 2008.

P. Silacci, Gelsolin superfamily proteins: Key regulators of cellular functions, Cellular and Molecular Life Sciences, pp.2614-2623, 2004.

D. N. Simon, M. S. Zastrow, and K. L. Wilson, Direct actin binding to A-and B-type lamin tails and actin filament bundling by the lamin A tail, Nucleus, 2010.

C. W. Siu, Modeling of lamin A / C mutation premature cardiac aging using patient-specific induced pluripotent stem cells, Aging, vol.4, issue.11, pp.803-822, 2012.

A. Skwarek-maruszewska, Contractility-dependent actin dynamics in cardiomyocyte sarcomeres, Journal of cell science, vol.122, pp.2119-2126, 2009.

A. Skwarek-maruszewska, Different localizations and cellular behaviors of leiomodin and tropomodulin in mature cardiomyocyte sarcomeres, Molecular biology of the cell, vol.21, issue.19, pp.3352-61, 2010.

S. Sonnylal, Postnatal induction of transforming growth factor beta signaling in fibroblasts of mice recapitulates clinical, histologic, and biochemical features of scleroderma, Arthritis and rheumatism, vol.56, issue.1, pp.334-378, 2007.

S. Sonnylal, Selective expression of connective tissue growth factor in fibroblasts in vivo promotes systemic tissue fibrosis, Arthritis and rheumatism, vol.62, issue.5, pp.1523-1555, 2010.

A. Sorrentino, The type I TGF-beta receptor engages TRAF6 to activate TAK1 in a receptor kinaseindependent manner, Nature cell biology, vol.10, issue.10, pp.1199-207, 2008.

S. Souchelnytskyi, Phosphorylation of Smad signaling proteins by receptor serine/threonine kinases, Methods in molecular biology, vol.124, pp.107-127, 2001.

F. S. Southwick, Gelsolin and ADF/cofilin enhance the actin dynamics of motile cells, Proceedings of the National Academy of Sciences of the United States of America, vol.97, issue.12, pp.6936-6938, 2000.

J. C. Sparrow and F. Schöck, The initial steps of myofibril assembly: integrins pave the way, Nature reviews. Molecular cell biology, vol.10, issue.4, pp.293-298, 2009.

D. Starr and M. Han, ANChors away: an actin based mechanism of nuclear positioning, Journal of cell science, vol.116, pp.211-216, 2003.

D. A. Starr and H. N. Fridolfsson, Interactions between nuclei and the cytoskeleton are mediated by SUNKASH nuclear-envelope bridges, Annual review of cell and developmental biology, vol.26, pp.421-465, 2010.

C. Stewart and B. Burke, Teratocarcinoma stem cells and early mouse embryos contain only a single major lamin polypeptide closely resembling lamin B, Cell, vol.51, issue.3, pp.383-392, 1987.

C. L. Stewart, K. J. Roux, and B. Burke, Blurring the boundary: the nuclear envelope extends its reach, Science, issue.5855, pp.1408-1412, 2007.

N. Stuurman, S. Heins, and U. Aebi, Nuclear lamins: their structure, assembly, and interactions, Journal of structural biology, vol.122, issue.1-2, pp.42-66, 1998.

N. Stuurman, B. Sasse, and P. Fisher, Intermediate filament protein polymerization: molecular analysis of Drosophila nuclear lamin head-to-tail binding, Journal of structural biology, vol.117, issue.1, pp.1-15, 1996.

C. Suarez, Cofilin tunes the nucleotide state of actin filaments and severs at bare and decorated segment boundaries, Current Biology, vol.21, issue.10, pp.862-868, 2011.
URL : https://hal.archives-ouvertes.fr/hal-00606357

K. Subramanian, Cofilin-2 phosphorylation and sequestration in myocardial aggregates: novel pathogenetic mechanisms for idiopathic dilated cardiomyopathy, Journal of the American College of Cardiology, vol.65, issue.12, pp.1199-214, 2015.

T. Sullivan, Loss of A-type lamin expression compromises nuclear envelope integrity leading to muscular dystrophy, The Journal of cell biology, vol.147, issue.5, pp.913-933, 1999.

G. Sun, Connective tissue growth factor is overexpressed in muscles of human muscular dystrophy, Journal of the neurological sciences, vol.267, issue.1-2, pp.48-56, 2008.

M. A. Sussman, Myofibril degeneration caused by tropomodulin overexpression leads to dilated cardiomyopathy in juvenile mice, The Journal of clinical investigation, vol.101, issue.1, pp.51-61, 1998.

M. A. Sussman, Prevention of Cardiac Hypertrophy in Mice by Calcineurin Inhibition, Science, vol.281, issue.5383, pp.1690-1693, 1998.

H. Suzuki, Exchangeability of actin in cardiac myocytes and fibroblasts as determined by fluorescence photobleaching recovery, Tissue and Cell, vol.30, issue.2, pp.274-280, 1998.

J. Swift, Nuclear lamin-A scales with tissue stiffness and enhances matrix-directed differentiation, Science, issue.6149, p.1240104, 2013.
DOI : 10.1126/science.1240104

URL : http://europepmc.org/articles/pmc3976548?pdf=render

N. Sylvius, In vivo and in vitro examination of the functional significances of novel lamin gene mutations in heart failure patients, Journal of medical genetics, vol.42, issue.8, pp.639-686, 2005.

Y. Takamori, Differential expression of nuclear lamin, the major component of nuclear lamina, during neurogenesis in two germinal regions of adult rat brain. The European journal of neuroscience, vol.25, pp.1653-62, 2007.

T. Takuma, Dephosphorylation of cofilin in parotid acinar cells, J Biochem, vol.120, issue.1, pp.35-41, 1996.

V. C. Tam, A Type III Secretion System in Vibrio cholerae Translocates a Formin/Spire Hybrid-like Actin Nucleator to Promote Intestinal Colonization, Cell Host and Microbe, vol.1, issue.2, pp.95-107, 2007.

K. Taniguchi, Mammalian formin Fhod3 regulates actin assembly and sarcomere organization in striated muscles, Journal of Biological Chemistry, vol.284, issue.43, pp.29873-29881, 2009.
DOI : 10.1074/jbc.m109.059303

URL : http://www.jbc.org/content/284/43/29873.full.pdf

.. L. Tatler and G. Jenkins, TGF-Activation and Lung Fibrosis, Proceedings of the American Thoracic Society, vol.9, pp.130-136, 2012.
DOI : 10.1513/pats.201201-003aw

M. R. Taylor, Natural history of dilated cardiomyopathy due to lamin A/C gene mutations, Journal of the American College of Cardiology, vol.41, issue.5, pp.771-80, 2003.

M. R. Taylor, Thymopoietin (lamina-associated polypeptide 2) gene mutation associated with dilated cardiomyopathy, Human Mutation, vol.26, issue.6, pp.566-574, 2005.
DOI : 10.1002/humu.20250

J. A. Theriot, Accelerating on a treadmill: ADF/Cofilin promotes rapid actin filament turnover in the dynamic cytoskeleton, Journal of Cell Biology, vol.136, issue.6, pp.1165-1168, 1997.

J. P. Thiery, Epithelial-mesenchymal transitions in development and pathologies S0955067403001339, 2003.
DOI : 10.1016/j.ceb.2003.10.006

, Curr Opin Cell Biol, vol.15, issue.6, pp.740-746

C. Thirion, Characterization of human muscle type cofilin (CFL2) in normal and regenerating muscle, European Journal of Biochemistry, vol.268, issue.12, pp.3473-3482, 2001.

J. Toshima, Cofilin Phosphorylation and Actin Reorganization Activities of Testicular Protein Kinase 2 and Its Predominant Expression in Testicular Sertoli Cells, Journal of Biological Chemistry, vol.276, issue.33, pp.31449-31458, 2001.

J. Toshima, Cofilin phosphorylation by protein kinase testicular protein kinase 1 and its role in integrinmediated actin reorganization and focal adhesion formation, Molecular biology of the cell, vol.12, issue.4, pp.1131-1176, 2001.

M. Van-troys, Ins and outs of ADF/cofilin activity and regulation, European Journal of Cell Biology, vol.87, issue.8-9, pp.649-667, 2008.

M. Tsai, A mitotic lamin B matrix induced by RanGTP required for spindle assembly, Science, issue.5769, pp.1887-93, 2006.
DOI : 10.1126/science.1122771

K. Tsuchida, Role of Smad4 on TGF-beta-induced extracellular matrix stimulation in mesangial cells, Kidney international, vol.63, pp.2000-2009, 2003.

Y. Turgay, SUN proteins facilitate the removal of membranes from chromatin during nuclear envelope breakdown, The Journal of Cell Biology, vol.204, issue.7, pp.1099-1109, 2014.

Y. B. Tzur, Matefin/SUN-1 is a nuclear envelope receptor for CED-4 during Caenorhabditis elegans apoptosis, Proceedings of the National Academy of Sciences, vol.103, issue.36, pp.13397-402, 2006.
DOI : 10.1073/pnas.0604224103

URL : http://www.pnas.org/content/103/36/13397.full.pdf

N. Umeki, K. Hirose, and T. Q. Uyeda, Cofilin-induced cooperative conformational changes of actin subunits revealed using cofilin-actin fusion protein, Scientific reports, vol.6, p.20406, 2016.

I. Varela, Accelerated ageing in mice deficient in Zmpste24 protease is linked to p53 signalling activation, Nature, vol.437, issue.7058, pp.564-568, 2005.

M. K. Vartiainen, The Three Mouse Actin-depolymerizing Factor / Cofilins Evolved to Fulfill Cell-Type-specific Requirements for Actin Dynamics, Molecular biology of the cell, vol.13, pp.183-194, 2002.

. Vaughan, Both emerin and lamin C depend on lamin A for localization at the nuclear envelope, Journal of cell science, vol.114, pp.2577-2590, 2001.

L. Vergnes, Lamin B1 is required for mouse development and nuclear integrity, Proceedings of the National Academy of Sciences of the United States of America, vol.101, issue.28, pp.10428-10461, 2004.
DOI : 10.1073/pnas.0401424101

URL : http://www.pnas.org/content/101/28/10428.full.pdf

S. Verheule, Increased vulnerability to atrial fibrillation in transgenic mice with selective atrial fibrosis caused by overexpression of TGF-??1, Circulation Research, vol.94, issue.11, pp.1458-1465, 2004.

F. Verrecchia, M. L. Chu, and A. Mauviel, Identification of novel TGF-beta /Smad gene targets in dermal fibroblasts using a combined cDNA microarray/promoter transactivation approach, The Journal of biological chemistry, vol.276, issue.20, pp.17058-62, 2001.

V. K. Vinson, Interactions of Acanthamoeba profilin with actin and nucleotides bound to actin, Biochemistry, vol.37, issue.31, pp.10871-10880, 1998.

T. Voit, Congenital muscular dystrophy with adducted thumbs, ptosis, external ophthalmoplegia, mental retardation and cerebellar hypoplasia: A novel form of CMD, Neuromuscular Disorders, pp.623-630, 2002.

K. Vorburger, A second higher vertebrate B-type lamin: cDNA sequence determination and in vitro processing of chicken lamin B2, Journal of Molecular Biology, vol.208, issue.3, pp.405-415, 1989.

E. Van-der-wal, F. Gómez-pinilla, and C. W. Cotman, Transforming growth factor-beta 1 is in plaques in Alzheimer and Down pathologies, Neuroreport, vol.4, issue.1, pp.69-72, 1993.

J. Waltenberger, Involvement of transforming growth factor-beta in the formation of fibrotic lesions in carcinoid heart disease. The American journal of pathology, vol.142, pp.71-79, 1993.

J. Wang, Dynamics of Z-band based proteins in developing skeletal muscle cells, Cell Motility and the Cytoskeleton, vol.61, issue.1, pp.34-48, 2005.

J. Wang, Novel microdeletion in the transforming growth factor beta type II receptor gene is associated with giant and large cell variants of nonsmall cell lung carcinoma, Genes, chromosomes & cancer, vol.46, issue.2, pp.192-201, 2007.

L. Wang, Requirement of mitogen-activated protein kinase kinase 3 (MKK3) for activation of p38alpha and p38delta MAPK isoforms by TGF-beta 1 in murine mesangial cells, The Journal of biological chemistry, vol.277, issue.49, pp.47257-62, 2002.

Y. Wang, A. J. Herron, and H. J. Worman, Pathology and nuclear abnormalities in hearts of transgenic mice expressing M371K lamin A encoded by an LMNA mutation causing Emery-Dreifuss muscular dystrophy, Human Molecular Genetics, vol.15, issue.16, pp.2479-2489, 2006.

D. T. Warren, Nesprins: intracellular scaffolds that maintain cell architecture and coordinate cell function?, Expert reviews in molecular medicine, vol.7, pp.1-15, 2005.
DOI : 10.1017/s1462399405009294

K. Warstat, TGF-beta enhances the integrin alpha2beta1-mediated attachment of mesenchymal stem cells to type I collagen, Stem cells and development, vol.19, issue.5, pp.645-56, 2010.

H. R. Waterham, Autosomal recessive HEM/Greenberg skeletal dysplasia is caused by 3 betahydroxysterol delta 14-reductase deficiency due to mutations in the lamin B receptor gene, American journal of human genetics, vol.72, issue.4, pp.1013-1020, 2003.

S. R. Wente and M. P. Rout, The Nuclear Pore Complex and Nuclear Transport, Cold Spring Harbor Perspectives in Biology, vol.2, issue.10, pp.562-000562, 2010.

K. Wilhelmsen, Nesprin-3, a novel outer nuclear membrane protein, associates with the cytoskeletal linker protein plectin, Journal of Cell Biology, vol.171, issue.5, pp.799-810, 2005.

M. C. Wilkes, Transforming growth factor-?? activation of phosphatidylinositol 3-kinase is independent of Smad2 and Smad3 and regulates fibroblast responses via p21-activated kinase-2, Cancer Research, vol.65, issue.22, pp.10431-10440, 2005.

K. L. Wilson and R. Foisner, Lamin-binding Proteins. Cold Spring Harbor perspectives in biology, vol.2, p.554, 2010.
DOI : 10.1101/cshperspect.a000554

URL : https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2845209

C. M. Wolf, Lamin A/C haploinsufficiency causes dilated cardiomyopathy and apoptosis-triggered cardiac conduction system disease, Journal of Molecular and Cellular Cardiology, vol.44, issue.2, pp.293-303, 2008.
DOI : 10.1016/j.yjmcc.2007.11.008

URL : http://europepmc.org/articles/pmc3011813?pdf=render

A. K. Wolven, In vivo importance of actin nucleotide exchange catalyzed by profilin, Journal of Cell Biology, vol.150, issue.4, pp.895-903, 2000.

H. J. Worman, Nuclear lamins and laminopathies, Journal of Pathology, vol.226, issue.2, pp.316-325, 2012.
DOI : 10.1002/path.2999

H. J. Worman and G. Bonne, Laminopathies": a wide spectrum of human diseases, Experimental cell research, vol.313, issue.10, pp.2121-2154, 2007.

H. J. Worman, C. D. Evans, and G. Blobel, The lamin B receptor of the nuclear envelope inner membrane: a polytopic protein with eight potential transmembrane domains, The Journal of cell biology, vol.111, issue.4, pp.1535-1577, 1990.

H. J. Worman and G. G. Gundersen, Here come the SUNs: A nucleocytoskeletal missing link, Trends in Cell Biology, vol.16, issue.2, pp.67-69, 2006.
DOI : 10.1016/j.tcb.2005.12.006

K. H. Wrighton, X. Lin, and X. Feng, Phospho-control of TGF-beta superfamily signaling, Cell research, vol.19, issue.1, pp.8-20, 2009.
DOI : 10.1038/cr.2008.327

URL : https://www.nature.com/articles/cr2008327.pdf

G. Wu, Structural basis of Smad2 recognition by the Smad anchor for receptor activation, Science, issue.5450, pp.92-97, 2000.

J. Wu, Inhibition of the EGF-activated MAP kinase signaling pathway by adenosine 3',5'monophosphate, Science, vol.262, issue.5136, pp.1065-1069, 1993.

W. Wu, Depletion of extracellular signal-regulated kinase 1 in mice with cardiomyopathy caused by lamin A/C gene mutation partially prevents pathology before isoenzyme activation, Human Molecular Genetics, vol.23, issue.1, pp.1-11, 2014.

W. Wu, Mitogen-activated protein kinase inhibitors improve heart function and prevent fibrosis in cardiomyopathy caused by mutation in Lamin A/C gene, Circulation, vol.123, issue.1, pp.53-61, 2011.

W. Wu, Pharmacological inhibition of c-Jun N-terminal kinase signaling prevents cardiomyopathy caused by mutation in LMNA gene, Biochimica et Biophysica Acta-Molecular Basis of Disease, pp.632-638, 2010.

K. Wulff, Six novel mutations in the emerin gene causing X-linked Emery-Dreifuss muscular dystrophy, Human Mutation, vol.9, issue.6, pp.526-530, 1997.
DOI : 10.1002/(sici)1098-1004(1997)9:6<526::aid-humu5>3.0.co;2-#

K. L. Wydner, Chromosomal Assignment of Human Nuclear Envelope Protein Genes LMNA, LMNB1, and LBR by Fluorescencein SituHybridization, 1996.
DOI : 10.1006/geno.1996.0146

L. Xie, Activation of the Erk pathway is required for TGF-beta1-induced EMT in vitro, Neoplasia, vol.6, issue.5, pp.603-613, 2004.

W. Xu, E. C. Leroy, and E. A. Smith, Fibronectin release by systemic sclerosis and normal dermal fibroblasts in response to TGF-?, Journal of Rheumatology, vol.18, issue.2, pp.241-246, 1991.

Y. Xu and B. Pasche, TGF-? signaling alterations and susceptibility to colorectal cancer, Human Molecular Genetics, issue.R1, p.16, 2007.
DOI : 10.1093/hmg/ddl486

URL : https://academic.oup.com/hmg/article-pdf/16/R1/R14/6950123/ddl486.pdf

H. Yamaguchi, Molecular mechanisms of invadopodium formation: the role of the N-WASP-Arp2/3 complex pathway and cofilin, The Journal of cell biology, vol.168, issue.3, pp.441-52, 2005.

A. Yamashita, K. Maeda, and Y. Maéda, Crystal structure of CapZ: Structural basis for actin filament barbed end capping, EMBO Journal, vol.22, issue.7, pp.1529-1538, 2003.
DOI : 10.1093/emboj/cdg167

URL : http://emboj.embopress.org/content/22/7/1529.full.pdf

M. Yanagita, Inhibitors/antagonists of TGF-? system in kidney fibrosis. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association-European Renal Association, vol.27, pp.3686-91, 2012.

S. H. Yang, Are B-type lamins essential in all mammalian cells?, Nucleus, vol.2, issue.6, pp.562-571, 2011.
DOI : 10.4161/nucl.2.6.18085

URL : http://europepmc.org/articles/pmc3324344?pdf=render

E. G. Yarmola, D. A. Dranishnikov, and M. R. Bubb, Effect of profilin on actin critical concentration: a theoretical analysis, Biophysical journal, vol.95, issue.12, pp.5544-73, 2008.

Q. Ye and H. J. Worman, Interaction between an Integral Protein of the Nuclear Envelope Inner Membrane and Human, pp.14653-14656, 1996.

Q. Ye and H. J. Worman, Primary structure analysis and lamin B and DNA binding of human LBR, an integral protein of the nuclear envelope inner membrane, The Journal of biological chemistry, vol.269, issue.15, pp.11306-11317, 1994.

N. Yonezawa, Inhibition of the interactions of cofilin, destrin, and deoxyribonuclease I with actin by phosphoinositides, Journal of Biological Chemistry, vol.265, issue.15, pp.8382-8386, 1990.

Y. Yoo, Tyrosine phosphorylation of cofilin at Y68 by v-Src leads to its degradation through ubiquitinproteasome pathway, Oncogene, vol.29, issue.2, pp.263-72, 2010.
DOI : 10.1038/onc.2009.319

URL : https://www.nature.com/articles/onc2009319.pdf

J. Yue and K. M. Mulder, Transforming growth factor-? signal transduction in epithelial cells, Pharmacology & Therapeutics, vol.91, issue.1, pp.1-34, 2001.
DOI : 10.1016/s0163-7258(01)00143-7

M. Yuen, Leiomodin-dysfunction results in thin filament disorganization and nemaline myopathy, Journal of Clinical Investigation, vol.124, issue.11, pp.4693-4708, 2014.
DOI : 10.1172/jci80057

URL : http://www.jci.org/articles/view/80057/files/pdf

M. S. Zastrow, S. Vlcek, and K. L. Wilson, Proteins that bind A-type lamins: integrating isolated clues, Journal of cell science, vol.117, pp.979-87, 2004.
DOI : 10.1242/jcs.01102

URL : http://jcs.biologists.org/content/117/7/979.full.pdf

J. Zavadil, Genetic programs of epithelial cell plasticity directed by transforming growth factor-beta, Proceedings of the National Academy of Sciences of the United States of America, vol.98, pp.6686-91, 2001.
DOI : 10.1073/pnas.111614398

URL : http://www.pnas.org/content/98/12/6686.full.pdf

T. Zhang, F. Wen, Y. Wu, G. S. Goh, Z. Ge et al., Cross-talk between TGF-beta/SMAD and integrin signaling pathways in regulating hypertrophy of mesenchymal stem cell chondrogenesis under deferral dynamic compression, Biomaterials, vol.38, pp.72-85, 2015.

D. Zhang, TAK1 is activated in the myocardium after pressure overload and is sufficient to provoke heart failure in transgenic mice, Nature medicine, vol.6, issue.5, pp.556-63, 2000.

H. Y. Zhang and S. H. Phan, Inhibition of myofibroblast apoptosis by transforming growth factor ?1, American Journal of Respiratory Cell and Molecular Biology, vol.21, issue.6, pp.658-665, 1999.
DOI : 10.1165/ajrcmb.21.6.3720

J. Zhang, Nesprin 1 is critical for nuclear positioning and anchorage, Human molecular genetics, vol.19, issue.2, pp.329-370, 2010.

Q. Zhang, Nesprin-1 and-2 are involved in the pathogenesis of Emery-Dreifuss muscular dystrophy and are critical for nuclear envelope integrity, Human Molecular Genetics, vol.16, issue.23, pp.2816-2833, 2007.

Q. Zhang, Nesprin-2 is a multi-isomeric protein that binds lamin and emerin at the nuclear envelope and forms a subcellular network in skeletal muscle, Journal of cell science, vol.118, pp.673-87, 2005.

Q. Zhang, Nesprins: a novel family of spectrin-repeat-containing proteins that localize to the nuclear membrane in multiple tissues, Journal of cell science, vol.114, pp.4485-98, 2001.

Y. Zhang, X. H. Feng, and R. Derynck, Smad3 and Smad4 cooperate with c-Jun/c-Fos to mediate TGF-betainduced transcription, Nature, vol.394, issue.6696, pp.909-922, 1998.

Y. E. Zhang, Non-Smad pathways in TGF-beta signaling, Cell research, vol.19, issue.1, pp.128-167, 2009.

S. Zhao, Profilin-1 promotes the development of hypertension-induced cardiac hypertrophy, Journal of Hypertension, vol.31, issue.3, pp.576-586, 2013.

Y. Zhen, NUANCE, a giant protein connecting the nucleus and actin cytoskeleton, Journal of cell science, vol.115, pp.3207-3222, 2002.

C. Zheng, $. Guan, and K. , Cloning and Characterization of Two Distinct Human Extracellular Signalregulated Kinase Activator Kinases, MEKl and MEK2*. the, Journal of Biological Chemistry, vol.268, issue.15, pp.11435-11439, 1993.

S. H. Zigmond, Formin Leaky Cap Allows Elongation in the Presence of Tight Capping Proteins, Current Biology, vol.13, issue.20, pp.1820-1823, 2003.

J. B. Zuchero, p53-cofactor JMY is a multifunctional actin nucleation factor, Nature cell biology, vol.11, issue.4, pp.451-460, 2009.

N. Zuela, D. Z. Bar, and Y. Gruenbaum, Lamins in development, tissue maintenance and stress, EMBO reports, vol.13, issue.12, pp.1070-1078, 2012.

M. Zwerger, Myopathic lamin mutations impair nuclear stability in cells and tissue and disrupt nucleocytoskeletal coupling, Human Molecular Genetics, vol.22, issue.12, pp.2335-2349, 2013.