F. Mujezinovic and Z. Alfirevic, Procedure-related complications of amniocentesis and Chorionic villous sampling: a systematic review, Obstet Gynecol, vol.110, pp.687-694, 2007.

H. Mouawia, A. Saker, J. P. Jais, A. Benachi, L. Bussieres et al., Circulating trophoblastic cells provide genetic diagnosis in 63 fetuses at risk for cystic fibrosis or spinal muscular atrophy, Reprod Biomed Online, vol.25, pp.508-520, 2012.

A. N. Imudia, S. Kumar, M. P. Diamond, A. H. Decherney, and D. R. Armant, Transcervical retrieval of fetal cells in the practice of modern medicine: a review of the current literature and future direction, Fertility and Sterility (Modern Trends), vol.93, pp.1725-1730, 2010.

J. O. Lo, D. F. Cori, M. E. Norton, and A. B. Caughey, Noninasive prenatal testing, Obstet Gynecol Surv, vol.69, pp.89-99, 2014.

N. Lench, A. Barrett, S. Fielding, F. Mckay, M. Hill et al., The clinical implementation of non-invasive prenatal diagnosis for single-gene disorders: challenges and progress made, Prenatal Diagnosis, vol.33, pp.555-562, 2013.

L. B. Shettles, Use of the Y chromosome in prenatal sex determination, Nature, vol.230, pp.52-53, 1971.

T. Ergin, V. Baltaci, H. B. Zeyneloglu, E. H. Duran, M. H. Ergeneli et al., Non-invasive early prenatal diagnosis using fluorescent in situ hybridization on transcervical cells: comparison of two different methods for retrieval, Eur J Obstet Gynecol Reprod Biol, vol.95, pp.37-41, 2001.

R. Cioni, C. Bussani, S. Bucciantini, and G. Scarselli, Fetal cells in a transcervical cell sample collected at 5 weeks of gestation, J Mat-Fet Neonat Med, vol.18, pp.271-273, 2005.

R. Cioni, C. Bussani, B. Scarselli, S. Bucciantini, M. Marchionni et al., Comparison of two techniques for transcervical cell sampling performed in the same study population

, Prenat Diagn, vol.25, pp.198-202, 2005.

C. Bussani, B. Scarselli, R. Cioni, S. Bucciantini, and G. Scarselli, Use of the quantitative fluorescent-PCR assay in the study of fetal DNA from micromanipulated transcervical samples, Mol Diagn, vol.8, pp.259-263, 2004.

J. Kingdom, J. Sherlock, C. Rodeck, and M. Adinolfi, Detection of trophoblast cells in transcervical samples collected by lavage or cytobrush, Obstet Gynecol, vol.86, pp.283-288, 1995.

A. Massari, G. Novelli, A. Colosimo, F. Sangiuolo, G. Palka et al., Non-invasive early prenatal molecular diagnosis using retrieved transcervical trophoblast cells, Hum Genet, vol.97, pp.150-155, 1996.

T. G. Overton, A. D. Lighten, N. M. Fisk, and P. R. Bennett, Fetus-Placenta-Newborn: Prenatal diagnosis by minimally invasive first-trimester transcervical sampling is unreliable, Am J Obstet Gynecol, vol.175, pp.382-387, 1996.

M. D. Fejgin, R. Diukman, Y. Cotton, G. Weinstein, and A. Amiel, Fetal cells in the uterine cervix: a source for early non-invasive prenatal diagnosis, Prenat Diagn, vol.21, pp.619-621, 2001.

R. Cioni, C. Bussani, B. Scarselli, S. Bucciantini, F. Barciulli et al., Fetal cells in cervical mucus in the first trimester of pregnancy, Prenat Diagn, vol.23, pp.168-171, 2003.

J. Sherlock, A. Halder, B. Tutschek, J. Delhanty, C. Rodeck et al., Prenatal detection offetal aneuploidies using transcervical cell samples, J Med Genet, vol.34, pp.302-305, 1997.

C. Falcinelli, S. Battafarano, C. Neri, V. Mazza, A. Ranzi et al., Analysis of fetal sex in TCC sample DNA: a contribution to the validation of this approach, Prenatal Diagnosis, vol.18, pp.1109-1116, 1998.

D. Mantzaris, D. Cram, C. Healy, D. Howlett, and G. Kovacs, Preliminary report: correct diagnosis of sex in fetal cells isolated from cervical mucus during early pregnancy. Australian and New Zealand, J Obstet Gynaecol, vol.45, pp.529-532, 2005.

S. D. Chang, S. L. Lin, K. K. Chu, and B. L. His, Minimally-invasive early prenatal diagnosis using fluorescence in situ hybridization on samples from uterine lavage, Prenat Diagn, vol.17, pp.1019-1025, 1997.

M. M. Chou, S. K. Lin, and E. S. Ho, Severe limb reduction defects after uterine lavage at 7-8 weeks' gestation, Prenat Diagn, vol.17, pp.77-80, 1997.

J. C. Foster and H. L. Smith, Use of the Cytobrush for Papanicolaou smear screens in pregnant women, J Nurse Midwifery, vol.41, pp.211-217, 1996.

G. Vona, C. Beroud, A. Benachi, A. Quenette, J. P. Bonnefont et al., Paterlini-Bréchot P. Enrichment, immunomorphological, and genetic characterization of fetal cells circulating in maternal blood, Am J Path, vol.160, pp.51-58, 2002.

G. Vona, A. Sabile, M. Louha, V. Sitruk, S. Romana et al., Isolation by size of epithelial tumor cells: a new method for the immunomorphological and molecular characterization of crirculating tumor cells, Am J Pathol, vol.156, pp.57-63, 2000.

C. Beroud, M. Karliova, J. P. Bonnefont, A. Benachi, A. Munnich et al., Prenatal diagnosis of spinal muscular atrophy by gentic analysis of circulating fetel cells, Lancet, vol.361, pp.1013-1017, 2003.

A. Saker, A. Benachi, J. P. Bonnefont, A. Munnich, Y. Dumez et al., Genetic characterisation of circulating fetal cells allows non-invasive prenatal diagnosis of cystic fibrosis, Prenatal Diagn, vol.26, pp.906-922, 2006.
DOI : 10.1002/pd.1524

L. Zhang, X. Cui, K. Schmitt, R. Hubert, W. Navidi et al., Whole genome amplification from a single cell: implications for genetic analysis, Proc Natl Acad Sci, vol.89, pp.5847-5851, 1992.
DOI : 10.1073/pnas.89.13.5847

URL : http://www.pnas.org/content/89/13/5847.full.pdf

S. A. Rhine, J. L. Cain, R. E. Cleary, C. G. Palmer, and J. F. Thompson, Prenatal sex detection with endocervical smears: successful results utilizing Y-bodyfluorescence, Am J Obstet Gynecol, vol.122, pp.155-160, 1975.
DOI : 10.1016/s0002-9378(16)33486-x

J. N. Bulmer, R. Cioni, C. Bussani, V. Cirigliano, F. Sole et al., HLAG positive trophoblastic cells in transcervical samples and their isolation and analysis by laser microdissection and QF-PCR, Prenat Diagn, vol.23, pp.34-39, 2003.
DOI : 10.1002/pd.511

M. L. Tjoa, L. Delli-bovi, K. L. Johnson, and D. W. Bianchi, Antibodies to trophoblast antigens HLAG, placenta growth factor, and neuroD2 do not improve detection of circulating trophoblast cells in maternal blood, Fetal Diagn Ther, vol.22, pp.85-89, 2007.

C. Bussani, R. Cioni, B. Scarselli, F. Barciulli, S. Bucciantini et al., Strategies for the isolation and detection of fetal cells in transcervical samples, Prenat Diagn, vol.22, pp.1098-1101, 2002.

C. N. Fang, Y. Y. Kan, and C. C. Hsiao, Detection of fetal cells from transcervical mucus plug before first-trimester termination of pregnancy by cytokeratin-7 immunohistochemistry

, J Obstet Gynaecol Res, vol.31, pp.500-507, 2005.

A. N. Imudia, Y. Suzuki, B. A. Kilburn, F. D. Yelian, M. P. Diamond et al., Retrieval of trophoblast cells from the cervical canal for prediction of abnormal pregnancy: a pilot study, Hum Reprod, vol.24, pp.2086-2092, 2009.

M. G. Katz-jaffe, D. Mantzaris, and D. S. Cram, DNA identification of fetal cells isolated from cervical mucus: potential for early non-invasive prenatal diagnosis, BJOG, vol.112, pp.595-600, 2005.

J. M. Bolnick, B. A. Kilburn, S. Bajpayee, N. Reddy, R. Jeelani et al., Trophoblast retrieval and isolation from the cervix (TRIC) for noninvasive prenatal screening at 5 to 20 weeks of gestation, Fertil Steril, vol.102, pp.135-177, 2014.

F. Fiorentino, A. Biricik, S. Bono, L. Spizzichino, E. Cotroneo et al., Development and validation of a next-generation sequencing-based protocol for 24-chromosome aneuploidy screening of embryos, References 1. Rhim AD, vol.101, pp.349-61, 2012.

P. Paterlini-brechot, Circulating Tumor Cells: Who is the Killer? Cancer Microenviron, vol.7, pp.161-76, 2014.

M. Ilie, V. Hofman, E. Long-mira, E. Selva, J. M. Vignaud et al., Sentinel" circulating tumor cells allow early diagnosis of lung cancer in patients with chronic obstructive pulmonary disease, PLoS One, vol.9, issue.10, p.25360587, 2014.
URL : https://hal.archives-ouvertes.fr/hal-01687052

P. Paterlini-brechot and N. L. Benali, Circulating tumor cells (CTC) detection: clinical impact and future directions, Cancer Lett, vol.253, issue.2, p.17314005, 2007.

D. R. Parkinson, N. Dracopoli, B. G. Petty, C. Compton, M. Cristofanilli et al., Considerations in the development of circulating tumor cell technology for clinical use, J Transl Med, vol.10, p.138, 2012.

M. G. Krebs, R. L. Metcalf, L. Carter, G. Brady, F. H. Blackhall et al., Molecular analysis of circulating tumour cells-biology and biomarkers, Nat Rev Clin Oncol, vol.11, issue.3, p.24445517, 2014.
DOI : 10.1038/nrclinonc.2013.253

M. Ignatiadis, M. Lee, and S. S. Jeffrey, Circulating Tumor Cells and Circulating Tumor DNA: Challenges and Opportunities on the Path to Clinical Utility, Clin Cancer Res, vol.21, issue.21, pp.4786-800, 2015.
DOI : 10.1158/1078-0432.ccr-14-1190

URL : http://clincancerres.aacrjournals.org/content/21/21/4786.full.pdf

A. , C. Pantel, and K. , Technologies for detection of circulating tumor cells: facts and vision, Lab Chip, vol.14, issue.1, pp.57-62, 2014.

M. M. Ferreira, V. C. Ramani, and S. S. Jeffrey, Circulating tumor cell technologies, Mol Oncol, vol.10, issue.3, pp.374-94, 2016.
DOI : 10.1016/j.molonc.2016.01.007

URL : http://europepmc.org/articles/pmc5528969?pdf=render

G. Vona, A. Sabile, M. Louha, V. Sitruk, S. Romana et al., Isolation by size of epithelial tumor cells: a new method for the immunomorphological and molecular characterization of circulatingtumor cells, Am J Pathol, vol.156, issue.1, pp.57-63, 2000.

A. Lecharpentier, P. Vielh, P. Perez-moreno, D. Planchard, J. C. Soria et al., Detection of circulating tumour cells with a hybrid (epithelial/mesenchymal) phenotype in patients with metastatic non-small cell lung cancer, Br J Cancer, vol.105, issue.9, pp.1338-1379, 2011.

M. G. Krebs, J. M. Hou, R. Sloane, L. Lancashire, L. Priest et al., Analysis of circulating tumor cells in patients with non-small cell lung cancer using epithelial marker-dependent and-independent approaches, J Thorac Oncol, vol.7, issue.2, pp.306-321, 2012.

V. Hofman, M. Ilie, E. Long, N. Guibert, E. Selva et al., Detection of circulating tumor cells from lung cancer patients in the era of targeted therapy: promises, drawbacks and pitfalls, Curr Mol Med, vol.14, issue.4, p.24730524, 2014.

A. , C. Pantel, and K. , Challenges in circulating tumour cell research, Nat Rev Cancer, vol.14, issue.9, pp.623-654, 2014.

K. Pantel, E. Deneve, D. Nocca, A. Coffy, J. P. Vendrell et al., Circulating epithelial cells in patients with benign colon diseases, Clin Chem, vol.58, issue.5, pp.936-976, 2012.
DOI : 10.1373/clinchem.2011.175570

URL : http://clinchem.aaccjnls.org/content/clinchem/58/5/936.full.pdf

V. J. Hofman, M. I. Ilie, C. Bonnetaud, E. Selva, E. Long et al., Cytopathologic detection of circulating tumor cells using the isolation by size of epithelial tumor cell method: promises and pitfalls, Am J Clin Pathol, vol.135, issue.1, pp.146-56, 2011.

C. J. Morrow, F. Trapani, R. L. Metcalf, G. Bertolini, C. L. Hodgkinson et al., Tumourigenic Non-Small Cell Lung Cancer Mesenchymal Circulating Tumour Cells-A Clinical Case Study, Ann Oncol, 2016.
DOI : 10.1093/annonc/mdw122

URL : https://academic.oup.com/annonc/article-pdf/27/6/1155/24168263/mdw122.pdf

K. E. Poruk, . Valero-v-3rd, T. Saunders, A. L. Blackford, J. F. Griffin et al., Circulating Tumor Cell Phenotype Predicts Recurrence and Survival in Pancreatic Adenocarcinoma, Ann Surg, 2016.
DOI : 10.1097/sla.0000000000001600

URL : http://europepmc.org/articles/pmc4936958?pdf=render

V. Hofman, M. Ilie, E. Long-mira, D. Giacchero, C. Butori et al., Usefulness of immunocytochemistry for the detection of the BRAF(V600E) mutation in circulating tumor cells from metastatic melanoma patients, J Invest Dermatol, vol.133, issue.5, p.23303445, 2013.

V. Hofman, M. I. Ilie, E. Long, E. Selva, C. Bonnetaud et al., Detection of circulating tumor cells as a prognostic factor in patients undergoing radical surgery for non-small cell lung carcinoma: Comparison of the efficacy of the CellSearch Assay and the isolation by size of epithelial tumor cell method, Int J Cancer, 2011.

M. Ilie, E. Long, C. Butori, V. Hofman, C. Coelle et al., ALK-gene rearrangement: a comparative analysis on circulating tumour cells and tumour tissue from patients with lung adenocarcinoma, Ann Oncol, vol.23, issue.11, pp.2907-2920, 2012.
DOI : 10.1093/annonc/mds137

URL : https://academic.oup.com/annonc/article-pdf/23/11/2907/13787256/mds137.pdf

E. Pailler, J. Adam, A. Barthelemy, M. Oulhen, N. Auger et al., Detection of circulating tumor cells harboring a unique ALK rearrangement in ALK-positive non-small-cell lung cancer, J Clin Oncol, vol.31, issue.18, pp.2273-81, 2013.

E. Pailler, N. Auger, C. R. Lindsay, P. Vielh, A. Islas-morris-hernandez et al., High level of chromosomal instability in circulating tumor cells of ROS1-rearranged non-small-cell lung cancer, Ann Oncol, vol.26, issue.7, pp.1408-1423, 2015.

G. Vona, L. Estepa, C. Beroud, D. Damotte, F. Capron et al., Impact of cytomorphological detection of circulating tumor cells in patients with liver cancer, References Abbaszadegan, vol.39, pp.792-799, 2004.

, Physiol, vol.232, 2008.

C. Abbosh, Phylogenetic ctDNA analysis depicts early-stage lung cancer evolution, Nature, vol.545, pp.446-451, 2017.

E. A. Abdallah, Thymidylate synthase expression in circulating tumor cells: a new tool to predict 5-fluorouracil resistance in metastatic colorectal cancer patients, Int. J. Cancer, vol.137, pp.1397-1405, 2015.

E. A. Abdallah, MRP1 expression in CTCs confers resistance to irinotecan-based chemotherapy in metastatic colorectal cancer, Int. J. Cancer, vol.139, pp.890-898, 2016.

M. Abdolahad, M. Taghinejad, H. Taghinejad, M. Janmaleki, and S. Mohajerzadeh, A vertically aligned carbon nanotube-based impedance sensing biosensor for rapid and high sensitive detection of cancer cells, Lab. Chip, vol.12, pp.1183-1190, 2012.

A. Abrahamsson and C. Dabrosin, Tissue specific expression of extracellular microRNA in human breast cancers and normal human breast tissue in vivo, Oncotarget, vol.6, pp.22959-22969, 2015.

N. Aceto, Circulating tumor cell clusters are oligoclonal precursors of breast cancer metastasis, Cell, vol.158, pp.1110-1122, 2014.

A. P. Adam, A. George, D. Schewe, P. Bragado, B. V. Iglesias et al., Computational identification of a p38SAPKregulated transcription factor network required for tumor cell quiescence, Cancer Res, vol.69, pp.5664-5672, 2009.

M. Adinolfi and J. Sherlock, Fetal cells in transcervical samples at an early stage of gestation, J. Hum. Genet, vol.46, pp.99-104, 2001.

R. Afik, Tumor macrophages are pivotal constructors of tumor collagenous matrix, J. Exp. Med, vol.213, pp.2315-2331, 2016.

J. A. Aguirre-ghiso, Models, mechanisms and clinical evidence for cancer dormancy, 2007.

, Rev. Cancer, vol.7, pp.834-846

A. Y. Alexandrova, K. Arnold, S. Schaub, J. M. Vasiliev, J. Meister et al., Comparative dynamics of retrograde actin flow and focal adhesions: formation of nascent adhesions triggers transition from fast to slow flow, PloS One, vol.3, p.3234, 2008.

M. Al-hajj, M. S. Wicha, A. Benito-hernandez, S. J. Morrison, C. et al., , 2003.

, Prospective identification of tumorigenic breast cancer cells, Proc. Natl. Acad. Sci. U. S. A, vol.100, pp.3983-3988

K. Alitalo, T. Tammela, and T. V. Petrova, Lymphangiogenesis in development and human disease, Nature, vol.438, pp.946-953, 2005.

C. Alix-panabières and K. Pantel, Clinical Applications of Circulating Tumor Cells and Circulating Tumor DNA as Liquid Biopsy, Cancer Discov, vol.6, pp.479-491, 2016.

N. Andor, T. A. Graham, M. Jansen, L. C. Xia, C. A. Aktipis et al., Pan-cancer analysis of the extent and consequences of intratumor heterogeneity, 2016.

. Med, , vol.22, pp.105-113

E. S. Antonarakis, AR-V7 and resistance to enzalutamide and abiraterone in prostate cancer, N. Engl. J. Med, vol.371, pp.1028-1038, 2014.

S. Arima, K. Nishiyama, T. Ko, Y. Arima, Y. Hakozaki et al., Angiogenic morphogenesis driven by dynamic and heterogeneous collective endothelial cell movement, Dev. Camb. Engl, vol.138, pp.4763-4776, 2011.
DOI : 10.1242/dev.068023

URL : http://dev.biologists.org/content/develop/138/21/4763.full.pdf

T. R. Ashworth, A case of cancer in which cells similar to those in the tumors were seen in the blood after death, Aus Med J, pp.146-155, 1869.

S. H. Au, Clusters of circulating tumor cells traverse capillary-sized vessels, Proc. Natl. Acad. Sci. U. S. A, vol.113, pp.4947-4952, 2016.
DOI : 10.1073/pnas.1524448113

URL : http://www.pnas.org/content/113/18/4947.full.pdf

I. Baccelli, Identification of a population of blood circulating tumor cells from breast cancer patients that initiates metastasis in a xenograft assay, Nat. Biotechnol, vol.31, pp.539-544, 2013.

Y. Bai, K. Shang, H. Chen, F. Ding, Z. Wang et al., FGF-1/-3/FGFR4 signaling in cancer-associated fibroblasts promotes tumor progression in colon cancer through Erk and MMP-7, Cancer Sci, vol.106, pp.1278-1287, 2015.
DOI : 10.1111/cas.12745

URL : http://europepmc.org/articles/pmc4637995?pdf=render

J. M. Balko, , pp.232-245, 2014.

R. E. Banks, Genetic and epigenetic analysis of von Hippel-Lindau (VHL) gene alterations and relationship with clinical variables in sporadic renal cancer, Cancer Res, vol.66, 2006.

D. Barkan, Metastatic growth from dormant cells induced by a col-I-enriched fibrotic environment, Cancer Res, vol.70, pp.5706-5716, 2010.

R. L. Barnhill, The biological and prognostic significance of angiotropism in uveal melanoma, Lab. Investig. J. Tech. Methods Pathol, 2017.

S. H. Barondes, D. N. Cooper, M. A. Gitt, and H. Leffler, Galectins. Structure and function of a large family of animal lectins, J. Biol. Chem, vol.269, pp.20807-20810, 1994.

E. Barreiro, V. Bustamante, V. Curull, J. Gea, J. L. López-campos et al., Relationships between chronic obstructive pulmonary disease and lung cancer: biological insights, 2016.

, J. Thorac. Dis, vol.8, pp.1122-1135

T. Celià-terrassa, Epithelial-mesenchymal transition can suppress major attributes of human epithelial tumor-initiating cells, J. Clin. Invest, vol.122, pp.1849-1868, 2012.

C. L. Chaffer, J. P. Brennan, J. L. Slavin, T. Blick, E. W. Thompson et al., , 2006.

, Mesenchymal-to-epithelial transition facilitates bladder cancer metastasis: role of fibroblast growth factor receptor-2, Cancer Res, vol.66, pp.11271-11278

M. Chang, Clinical Significance of Circulating Tumor Microemboli as a Prognostic Marker in Patients with Pancreatic Ductal Adenocarcinoma, Clin. Chem, vol.62, pp.505-513, 2016.

J. R. Chapman, A. C. Webster, and G. Wong, , 2013.

Z. Chen, Cellular and Molecular Identity of Tumor-Associated Macrophages in Glioblastoma, Cancer Res, vol.77, pp.2266-2278, 2017.

G. Cheng, J. Tse, R. K. Jain, and L. L. Munn, Micro-environmental mechanical stress controls tumor spheroid size and morphology by suppressing proliferation and inducing apoptosis in cancer cells, PloS One, vol.4, p.4632, 2009.

L. Cheng, G. T. Maclennan, S. Zhang, M. Wang, M. Zhou et al., Evidence for polyclonal origin of multifocal clear cell renal cell carcinoma, Clin. Cancer Res. Off. J. Am. Assoc. Cancer Res, vol.14, pp.8087-8093, 2008.

L. Cheng, S. Zhang, G. T. Maclennan, A. Lopez-beltran, and R. Montironi, Molecular and cytogenetic insights into the pathogenesis, classification, differential diagnosis, and prognosis of renal epithelial neoplasms, Hum. Pathol, vol.40, pp.10-29, 2009.

T. H. Cheung and T. A. Rando, Molecular regulation of stem cell quiescence, Nat. Rev, 2013.

, Mol. Cell Biol, vol.14, pp.329-340

I. Cima, Tumor-derived circulating endothelial cell clusters in colorectal cancer, Sci. Transl. Med, vol.8, pp.345-89, 2016.

S. J. Cohen, Relationship of circulating tumor cells to tumor response, progressionfree survival, and overall survival in patients with metastatic colorectal cancer, J. Clin. Oncol. Off, 2008.

, J. Am. Soc. Clin. Oncol, vol.26, pp.3213-3221

A. T. Collins, P. A. Berry, C. Hyde, M. J. Stower, and N. J. Maitland, Prospective identification of tumorigenic prostate cancer stem cells, Cancer Res, vol.65, pp.10946-10951, 2005.

V. P. Collins, R. K. Loeffler, and H. Tivey, Observations on growth rates of human tumors, Am. J. Roentgenol. Radium Ther. Nucl. Med, vol.76, pp.988-1000, 1956.

C. Corrò, Detecting circulating tumor DNA in renal cancer: An open challenge, 2017.

, Mol. Pathol, vol.102, pp.255-261

F. A. Coumans, G. Van-dalum, M. Beck, and L. W. Terstappen, Filter characteristics influencing circulating tumor cell enrichment from whole blood, PloS One, vol.8, 2013.

C. L. Cowey and W. K. Rathmell, VHL gene mutations in renal cell carcinoma: role as a biomarker of disease outcome and drug efficacy, Curr. Oncol. Rep, vol.11, pp.94-101, 2009.

M. Cristofanilli, Circulating tumor cells, disease progression, and survival in metastatic breast cancer, N. Engl. J. Med, vol.351, pp.781-791, 2004.

M. Cristofanilli, Circulating tumor cells: a novel prognostic factor for newly diagnosed metastatic breast cancer, J. Clin. Oncol. Off. J. Am. Soc. Clin. Oncol, vol.23, pp.1420-1430, 2005.

M. D. Curley, CD133 expression defines a tumor initiating cell population in primary human ovarian cancer, Stem Cells Dayt. Ohio, vol.27, pp.2875-2883, 2009.

A. M. Czarnecka, A. Kornakiewicz, W. Kukwa, and C. Szczylik, Frontiers in clinical and molecular diagnostics and staging of metastatic clear cell renal cell carcinoma, Future Oncol. Lond. Engl, vol.10, pp.1095-1111, 2014.

J. Dagher, S. Kammerer-jacquet, F. Dugay, M. Beaumont, A. Lespagnol et al., Clear cell renal cell carcinoma: a comparative study of histological and chromosomal characteristics between primary tumors and their corresponding metastases, Virchows Arch. Int. J. Pathol, 2017.
URL : https://hal.archives-ouvertes.fr/hal-01560281

D. C. Danila, Circulating tumor cell number and prognosis in progressive castrationresistant prostate cancer, Clin. Cancer Res. Off. J. Am. Assoc. Cancer Res, vol.13, pp.7053-7058, 2007.

E. Denève, S. Riethdorf, J. Ramos, D. Nocca, A. Coffy et al., Capture of viable circulating tumor cells in the liver of colorectal cancer patients, Clin. Chem, vol.59, pp.1384-1392, 2013.

R. Derynck, R. J. Akhurst, and A. Balmain, TGF-beta signaling in tumor suppression and cancer progression, Nat. Genet, vol.29, pp.117-129, 2001.

E. I. Deryugina and J. P. Quigley, Tumor angiogenesis: MMP-mediated induction of intravasation-and metastasis-sustaining neovasculature, Matrix Biol. J. Int. Soc. Matrix Biol. 44, vol.46, pp.94-112, 2015.

D. L. Dexter, H. M. Kowalski, B. A. Blazar, Z. Fligiel, R. Vogel et al., , 1978.

, Heterogeneity of tumor cells from a single mouse mammary tumor, Cancer Res, vol.38, pp.3174-3181

L. Doridot, D. Houry, H. Gaillard, S. T. Chelbi, S. Barbaux et al., miR-34a expression, epigenetic regulation, and function in human placental diseases, Epigenetics, vol.9, pp.142-151, 2014.

L. Doridot, F. Miralles, S. Barbaux, and D. Vaiman, Trophoblasts, invasion, and microRNA, p.248, 2013.
URL : https://hal.archives-ouvertes.fr/inserm-01067928

C. A. Drummond, Cigarette smoking causes epigenetic changes associated with cardiorenal fibrosis, Physiol. Genomics, vol.48, pp.950-960, 2016.

C. Dumontet, J. , and M. A. , Microtubule-binding agents: a dynamic field of cancer therapeutics, Nat. Rev. Drug Discov, vol.9, p.239, 2010.
URL : https://hal.archives-ouvertes.fr/inserm-00526519

F. Aubin, H. Lucile-broncy-easwaran, H. Tsai, and S. B. Baylin, Cancer epigenetics: tumor heterogeneity, plasticity of stem-like states, and drug resistance, Mol. Cell, vol.54, pp.716-727, 2014.

A. El-heliebi, Are morphological criteria sufficient for the identification of circulating tumor cells in renal cancer?, J. Transl. Med, vol.11, p.214, 2013.

B. Erdogan, W. , and D. J. , Cancer-associated fibroblasts modulate growth factor signaling and extracellular matrix remodeling to regulate tumor metastasis, Biochem. Soc. Trans, vol.45, pp.229-236, 2017.

B. H. Faas, J. De-ligt, I. Janssen, A. J. Eggink, L. D. Wijnberger et al., Non-invasive prenatal diagnosis of fetal aneuploidies using massively parallel sequencing-by-ligation and evidence that cell-free fetal DNA in the maternal plasma originates from cytotrophoblastic cells, Expert Opin. Biol. Ther, vol.12, pp.19-26, 2012.

F. Fabbri, Detection and recovery of circulating colon cancer cells using a dielectrophoresis-based device: KRAS mutation status in pure CTCs, Cancer Lett, vol.335, pp.225-231, 2013.

G. P. Fadini, S. Ciciliot, A. , and M. , Concise Review: Perspectives and Clinical Implications of Bone Marrow and Circulating Stem Cell Defects in Diabetes, Stem Cells Dayt. Ohio, vol.35, pp.106-116, 2017.

F. Farace, A direct comparison of CellSearch and ISET for circulating tumour-cell detection in patients with metastatic carcinomas, Br. J. Cancer, vol.105, pp.847-853, 2011.

V. Faugeroux, E. Pailler, N. Auger, M. Taylor, F. et al., Clinical Utility of Circulating Tumor Cells in ALK-Positive Non-Small, Cell Lung Cancer. Front. Oncol, vol.4, p.281, 2014.

I. J. Fidler, Biological behavior of malignant melanoma cells correlated to their survival in vivo, Cancer Res, vol.35, pp.218-224, 1975.

I. J. Fidler, The pathogenesis of cancer metastasis: the "seed and soil" hypothesis revisited, Nat. Rev. Cancer, vol.3, pp.453-458, 2003.

A. N. Fischer, E. Fuchs, M. Mikula, H. Huber, H. Beug et al., PDGF essentially links TGF-beta signaling to nuclear beta-catenin accumulation in hepatocellular carcinoma progression, Oncogene, vol.26, pp.3395-3405, 2007.

M. Y. Fong, Breast-cancer-secreted miR-122 reprograms glucose metabolism in premetastatic niche to promote metastasis, Nat. Cell Biol, vol.17, pp.183-194, 2015.

J. R. Forman, C. L. Worth, G. R. Bickerton, T. G. Eisen, and T. L. Blundell, Structural bioinformatics mutation analysis reveals genotype-phenotype correlations in von Hippel-Lindau disease and suggests molecular mechanisms of tumorigenesis, Proteins, vol.77, pp.84-96, 2009.

D. L. Franco, J. Mainez, S. Vega, P. Sancho, M. M. Murillo et al., Snail1 suppresses TGF-beta-induced apoptosis and is sufficient to trigger EMT in hepatocytes, J. Cell Sci, vol.123, pp.3467-3477, 2010.
DOI : 10.1242/dev.059907

I. J. Frew and H. Moch, A clearer view of the molecular complexity of clear cell renal cell carcinoma, Annu. Rev. Pathol, vol.10, pp.263-289, 2015.

P. Friedl, W. , and K. , Plasticity of cell migration: a multiscale tuning model, J. Cell Biol, p.240, 2010.
DOI : 10.1083/jcb.200909003

URL : http://jcb.rupress.org/content/188/1/11.full.pdf

, Orme aux Merisiers RD 128 / 91190 Saint-Aubin, France Lucile BRONCY, vol.188, pp.11-19

M. Furuse, Molecular basis of the core structure of tight junctions, 2010.

, Perspect. Biol, vol.2, p.2907

C. Gaggioli, S. Hooper, C. Hidalgo-carcedo, R. Grosse, J. F. Marshall et al., Fibroblast-led collective invasion of carcinoma cells with differing roles for RhoGTPases in leading and following cells, Nat. Cell Biol, vol.9, pp.1392-1400, 2007.

C. Gallou, Mutations of the VHL gene in sporadic renal cell carcinoma: definition of a risk factor for VHL patients to develop an RCC, Hum. Mutat, vol.13, pp.464-475, 1999.

C. Gallou, Association of GSTT1 non-null and NAT1 slow/rapid genotypes with von, 2001.

, Hippel-Lindau tumour suppressor gene transversions in sporadic renal cell carcinoma, Pharmacogenetics, vol.11, pp.521-535

M. A. Gama-sosa, V. A. Slagel, R. W. Trewyn, R. Oxenhandler, K. C. Kuo et al., The 5-methylcytosine content of DNA from human tumors, Nucleic Acids Res, vol.11, pp.6883-6894, 1983.

D. Gao, Organoid cultures derived from patients with advanced prostate cancer, Cell, vol.159, pp.176-187, 2014.

H. Gao, G. Chakraborty, A. P. Lee-lim, Q. Mo, M. Decker et al., The BMP inhibitor Coco reactivates breast cancer cells at lung metastatic sites, Cell, vol.150, pp.764-779, 2012.

W. Gao, W. Li, T. Xiao, X. S. Liu, and W. G. Kaelin, Inactivation of the PBRM1 tumor suppressor gene amplifies the HIF-response in VHL-/-clear cell renal carcinoma, Proc. Natl. Acad, 2017.

. U. Sci, , vol.114, pp.1027-1032

Y. Gao, , 2017.

, Genome Res

G. J. Gasic, T. B. Gasic, and C. C. Stewart, Antimetastatic effects associated with platelet reduction, Proc. Natl. Acad. Sci. U. S. A, vol.61, pp.46-52, 1968.

R. A. Gatenby and T. L. Vincent, An evolutionary model of carcinogenesis, Cancer Res, vol.63, pp.6212-6220, 2003.

L. J. Gay and B. Felding-habermann, Contribution of platelets to tumour metastasis, 2011.

, Rev. Cancer, vol.11, pp.123-134

V. Georgoulias, V. Bozionelou, S. Agelaki, M. Perraki, S. Apostolaki et al., Trastuzumab decreases the incidence of clinical relapses in patients with early breast cancer presenting chemotherapy-resistant CK-19mRNA-positive circulating tumor cells: results of a randomized phase II study, Ann. Oncol. Off. J. Eur. Soc. Med, 2012.

, Oncol, vol.23, pp.1744-1750

M. Gerlinger, Intratumor heterogeneity and branched evolution revealed by multiregion sequencing, N. Engl. J. Med, vol.366, pp.883-892, 2012.

M. Gerlinger, Genomic architecture and evolution of clear cell renal cell carcinomas defined by multiregion sequencing, Nat. Genet, vol.46, pp.225-233, 2014.

M. Gerstung, C. Beisel, M. Rechsteiner, P. Wild, P. Schraml et al., Reliable detection of subclonal single-nucleotide variants in tumour cell populations, 2012.

, Commun, vol.3, p.811

C. M. Ghajar, The perivascular niche regulates breast tumour dormancy, Nat. Cell Biol, vol.15, pp.807-817, 2013.

S. Giampieri, C. Manning, S. Hooper, L. Jones, C. S. Hill et al., Localized and reversible TGFbeta signalling switches breast cancer cells from cohesive to single cell motility, 2009.

, Cell Biol, vol.11, pp.1287-1296

S. A. Godinho, R. Picone, M. Burute, R. Dagher, Y. Su et al., Oncogene-like induction of cellular invasion from centrosome amplification, Nature, vol.510, pp.167-171, 2014.
URL : https://hal.archives-ouvertes.fr/hal-00985663

S. E. Goelz, B. Vogelstein, S. R. Hamilton, and A. P. Feinberg, Hypomethylation of DNA from benign and malignant human colon neoplasms, Science, vol.228, pp.187-190, 1985.

J. D. Gordan, HIF-alpha effects on c-Myc distinguish two subtypes of sporadic VHLdeficient clear cell renal carcinoma, Cancer Cell, vol.14, pp.435-446, 2008.

L. Gossage, T. Eisen, and E. R. Maher, VHL, the story of a tumour suppressor gene, 2015.

, Rev. Cancer, vol.15, pp.55-64

L. Gossage, D. E. Pires, Á. Olivera-nappa, J. Asenjo, M. Bycroft et al., An integrated computational approach can classify VHL missense mutations according to risk of clear cell renal carcinoma, Hum. Mol. Genet, vol.23, pp.5976-5988, 2014.

L. Gossage, D. E. Pires, Á. Olivera-nappa, J. Asenjo, M. Bycroft et al., An integrated computational approach can classify VHL missense mutations according to risk of clear cell renal carcinoma, Hum. Mol. Genet, vol.23, pp.5976-5988, 2014.

S. Goswami, E. Sahai, J. B. Wyckoff, M. Cammer, D. Cox et al., Macrophages promote the invasion of breast carcinoma cells via a colony-stimulating factor-1/epidermal growth factor paracrine loop, Cancer Res, vol.65, pp.5278-5283, 2005.

A. Gradilone, Circulating tumor cells and "suspicious objects" evaluated through CellSearch® in metastatic renal cell carcinoma, Anticancer Res, vol.31, pp.4219-4221, 2011.

C. Grange, M. Tapparo, F. Collino, L. Vitillo, C. Damasco et al., Microvesicles released from human renal cancer stem cells stimulate angiogenesis and formation of lung premetastatic niche, Cancer Res, vol.71, pp.5346-5356, 2011.

J. I. Greenberg, A role for VEGF as a negative regulator of pericyte function and vessel maturation, Nature, vol.456, pp.809-813, 2008.

F. Grillet, , 2016.

P. Grosse-gehling, C. A. Fargeas, C. Dittfeld, Y. Garbe, M. R. Alison et al., CD133 as a biomarker for putative cancer stem cells in solid tumours: limitations, problems and challenges, J. Pathol, vol.229, pp.355-378, 2013.

R. Grozovsky, S. Giannini, H. Falet, and K. M. Hoffmeister, Regulating billions of blood P a g e | 242, 2015.

, platelets: glycans and beyond, vol.126, pp.1877-1884

J. Guck, Optical deformability as an inherent cell marker for testing malignant transformation and metastatic competence, Biophys. J, vol.88, pp.3689-3698, 2005.

S. Gulati, Systematic evaluation of the prognostic impact and intratumour heterogeneity of clear cell renal cell carcinoma biomarkers, Eur. Urol, vol.66, pp.936-948, 2014.

G. Hadfield, The dormant cancer cell, Br. Med. J, vol.2, pp.607-610, 1954.

S. Hahn, B. Huppertz, and W. Holzgreve, Fetal cells and cell free fetal nucleic acids in maternal blood: new tools to study abnormal placentation, Placenta, vol.26, pp.515-526, 2005.

W. Han, Oriented collagen fibers direct tumor cell intravasation, Proc. Natl. Acad. Sci, 2016.

U. S. , , vol.113, pp.11208-11213

X. Han, J. Wang, and Y. Sun, Circulating Tumor DNA as Biomarkers for Cancer Detection, 2017.

, Genomics Proteomics Bioinformatics, vol.15, pp.59-72

N. J. Hannan, R. L. Jones, C. A. White, and L. A. Salamonsen, The chemokines, CX3CL1, CCL14, and CCL4, promote human trophoblast migration at the feto-maternal interface, Biol, 2006.

. Reprod, , vol.74, pp.896-904

A. S. Harney, E. N. Arwert, D. Entenberg, Y. Wang, P. Guo et al., Real-Time Imaging Reveals Local, Transient Vascular Permeability, and Tumor Cell Intravasation Stimulated by TIE2hi Macrophage-Derived VEGFA, Cancer Discov, vol.5, pp.932-943, 2015.

R. A. Harouaka, M. Nisic, and S. Zheng, Circulating tumor cell enrichment based on physical properties, J. Lab. Autom, vol.18, pp.455-468, 2013.

R. Harouaka, Z. Kang, S. Zheng, C. , and L. , Circulating tumor cells: advances in isolation and analysis, and challenges for clinical applications, Pharmacol. Ther, vol.141, pp.209-221, 2014.

K. Hayata, Y. Hiramatsu, H. Masuyama, E. Eto, T. Mitsui et al., Discrepancy between Non-invasive Prenatal Genetic Testing (NIPT) and Amniotic Chromosomal Test due to, 2017.

, Placental Mosaicism: A Case Report and Literature Review, Acta Med. Okayama, vol.71, pp.181-185

R. L. Heise, P. A. Link, and L. Farkas, From Here to There, Progenitor Cells and Stem Cells Are Everywhere in Lung Vascular Remodeling. Front, 2016.

S. Hiratsuka, A. Watanabe, H. Aburatani, and Y. Maru, Tumour-mediated upregulation of chemoattractants and recruitment of myeloid cells predetermines lung metastasis, Nat. Cell Biol, vol.8, pp.1369-1375, 2006.

S. Hobor, B. O. Van-emburgh, E. Crowley, S. Misale, F. Di-nicolantonio et al., , 2014.

, TGF? and amphiregulin paracrine network promotes resistance to EGFR blockade in colorectal cancer cells, Clin. Cancer Res. Off. J. Am. Assoc. Cancer Res, vol.20, pp.6429-6438

C. L. Hodgkinson, Tumorigenicity and genetic profiling of circulating tumor cells in small-cell lung cancer, Nat. Med, vol.20, pp.897-903, 2014.

V. Hofman, , 2011.

, Cancer Res. Off. J. Am. Assoc. Cancer Res, vol.17, pp.827-835

V. Hofman, Off. J. Br. Soc. Clin. Cytol, vol.23, pp.30-38, 2012.

V. Hofman, Usefulness of immunocytochemistry for the detection of the BRAF(V600E) mutation in circulating tumor cells from metastatic melanoma patients, J. Invest, 2013.

. Dermatol, , vol.133, pp.1378-1381

V. Hofman, Detection of circulating tumor cells from lung cancer patients in the era of targeted therapy: promises, drawbacks and pitfalls, Curr. Mol. Med, vol.14, pp.440-456, 2014.

V. Hofman, M. I. Ilie, E. Long, E. Selva, C. Bonnetaud et al., Detection of circulating tumor cells as a prognostic factor in patients undergoing radical surgery for non-small-cell lung carcinoma: comparison of the efficacy of the CellSearch Assay TM and the isolation by size of epithelial tumor cell method, Int. J. Cancer, vol.129, pp.1651-1660, 2011.

V. J. Hofman, Cytopathologic detection of circulating tumor cells using the isolation by size of epithelial tumor cell method: promises and pitfalls, Am. J. Clin. Pathol, vol.135, pp.146-156, 2011.

V. J. Hofman, M. Ilie, and P. M. Hofman, Detection and characterization of circulating tumor cells in lung cancer: Why and how? Cancer Cytopathol, vol.124, pp.380-387, 2016.

L. Holmgren, A. Szeles, E. Rajnavölgyi, J. Folkman, G. Klein et al., , 1999.

, Horizontal transfer of DNA by the uptake of apoptotic bodies, Blood, vol.93, pp.3956-3963

A. Hoshino, Tumour exosome integrins determine organotropic metastasis, Nature, vol.527, pp.329-335, 2015.

J. Hou, Clinical significance and molecular characteristics of circulating tumor cells and circulating tumor microemboli in patients with small-cell lung cancer, J. Clin. Oncol. Off. J. Am, 2012.

. Soc, Clin. Oncol, vol.30, pp.525-532

J. J. Hsieh, M. P. Purdue, S. Signoretti, C. Swanton, L. Albiges et al.,

J. Larkin and V. Ficarra, Renal cell carcinoma, Nat. Rev. Dis. Primer, vol.3, p.17009, 2017.

W. Hu, T. Wang, Y. Yang, and S. Zheng, Tumor heterogeneity uncovered by dynamic expression of long noncoding RNA at single-cell resolution, Cancer Genet, vol.208, pp.581-586, 2015.
DOI : 10.1016/j.cancergen.2015.09.005

X. Huang, P. Gao, Y. Song, J. Sun, X. Chen et al., Metaanalysis of the prognostic value of circulating tumor cells detected with the CellSearch System in colorectal cancer, BMC Cancer, vol.15, p.202, 2015.

R. C. Hughes, Galectins as modulators of cell adhesion, Biochimie, vol.83, pp.667-676, 2001.

N. M. Hunkapiller and S. J. Fisher, Chapter 12. Placental remodeling of the uterine vasculature, Methods Enzymol, vol.445, pp.281-302, 2008.

Y. Hüsemann, Systemic spread is an early step in breast cancer, Cancer Cell, vol.13, p.58, 2008.

I. Hwang, J. Kim, J. , and S. , , p.244, 2012.

, Orme aux Merisiers RD 128 / 91190 Saint-Aubin, France in colon cancer cells, J. Biol. Chem, vol.287, pp.41364-41373

M. Ilie, ALK-gene rearrangement: a comparative analysis on circulating tumour cells and tumour tissue from patients with lung adenocarcinoma, Ann. Oncol. Off. J. Eur. Soc. Med, 2012.

, Oncol, vol.23, pp.2907-2913

M. Ilie, V. Hofman, E. Long-mira, E. Selva, J. Vignaud et al., , 2014.

A. N. Imudia, Y. Suzuki, B. A. Kilburn, F. D. Yelian, M. P. Diamond et al., Retrieval of trophoblast cells from the cervical canal for prediction of abnormal pregnancy: a pilot study, Hum. Reprod. Oxf. Engl, vol.24, pp.2086-2092, 2009.

M. Inda, Tumor heterogeneity is an active process maintained by a mutant EGFRinduced cytokine circuit in glioblastoma, Genes Dev, vol.24, pp.1731-1745, 2010.

F. Islam, V. Gopalan, R. A. Smith, A. K. Lam, and .. , Translational potential of cancer stem cells: A review of the detection of cancer stem cells and their roles in cancer recurrence and cancer treatment, Exp. Cell Res, vol.335, pp.135-147, 2015.

B. M. Jacobsen, J. C. Harrell, P. Jedlicka, V. F. Borges, M. Varella-garcia et al., Spontaneous fusion with, and transformation of mouse stroma by, malignant human breast cancer epithelium, Cancer Res, vol.66, pp.8274-8279, 2006.

C. V. Jain, Fetal genome profiling at 5 weeks of gestation after noninvasive isolation of trophoblast cells from the endocervical canal, Sci. Transl. Med, vol.8, pp.363-367, 2016.

M. J. Janatpour, M. T. Mcmaster, O. Genbacev, Y. Zhou, J. Dong et al., Id-2 regulates critical aspects of human cytotrophoblast differentiation, invasion and migration, Dev. Camb. Engl, vol.127, pp.549-558, 2000.

M. K. Jolly, S. C. Tripathi, D. Jia, S. M. Mooney, M. Celiktas et al., Stability of the hybrid epithelial/mesenchymal phenotype, Oncotarget, vol.7, pp.27067-27084, 2016.

S. A. Joosse, T. M. Gorges, and K. Pantel, Biology, detection, and clinical implications of circulating tumor cells, EMBO Mol. Med, vol.7, pp.1-11, 2015.

J. A. Joyce and J. W. Pollard, Microenvironmental regulation of metastasis, Nat. Rev. Cancer, vol.9, pp.239-252, 2009.

H. Kanno, T. Shuin, K. Kondo, I. Yamamoto, S. Ito et al.,

R. N. Kaplan, VEGFR1-positive haematopoietic bone marrow progenitors initiate the pre-metastatic niche, Nature, vol.438, pp.820-827, 2005.

N. O. Karpinich, C. , and K. M. , Gap junction coupling is required for tumor cell migration through lymphatic endothelium, Arterioscler. Thromb. Vasc. Biol, vol.35, pp.1147-1155, 2015.

T. G. Karrison, D. J. Ferguson, M. , and P. , Dormancy of mammary carcinoma after, 1999.

M. G. Krebs, Circulating Tumor Cell Enumeration in a Phase II Trial of a Four-Drug Regimen in Advanced Colorectal Cancer, Clin. Colorectal Cancer, vol.14, pp.115-122, 2015.

R. T. Krivacic, A rare-cell detector for cancer, Proc. Natl. Acad. Sci. U. S. A, vol.101, pp.10501-10504, 2004.

N. Kubo, K. Araki, H. Kuwano, and K. Shirabe, Cancer-associated fibroblasts in hepatocellular carcinoma, World J. Gastroenterol, vol.22, pp.6841-6850, 2016.

C. Kudo-saito, H. Shirako, T. Takeuchi, and Y. Kawakami, , 2009.

F. Kukulski, F. Ben-yebdri, F. Bahrami, M. Fausther, A. Tremblay et al., , 2010.

, Endothelial P2Y2 receptor regulates LPS-induced neutrophil transendothelial migration in vitro

, Mol. Immunol, vol.47, pp.991-999

C. Kuperwasser, T. Chavarria, M. Wu, G. Magrane, J. W. Gray et al., Reconstruction of functionally normal and malignant human breast tissues in mice, Proc. Natl. Acad. Sci. U. S. A, vol.101, pp.4966-4971, 2004.

N. K. Kurrey, S. P. Jalgaonkar, A. V. Joglekar, A. D. Ghanate, P. D. Chaskar et al., Snail and slug mediate radioresistance and chemoresistance by antagonizing p53-mediated apoptosis and acquiring a stem-like phenotype in ovarian cancer cells, 2009.

, Stem Cells Dayt. Ohio, vol.27, pp.2059-2068

B. Küsters, G. Kats, I. Roodink, K. Verrijp, P. Wesseling et al., Micronodular transformation as a novel mechanism of VEGF-A-induced metastasis, Oncogene, vol.26, pp.5808-5815, 2007.

L. Kuthi, A. Jenei, A. Hajdu, I. Németh, Z. Varga et al., , 2017.

, Prognostic Factors for Renal Cell Carcinoma Subtypes Diagnosed According to the 2016 WHO Renal Tumor Classification: a Study Involving 928 Patients, Pathol. Oncol. Res. POR, vol.23, pp.689-698

M. Labelle, S. Begum, and R. O. Hynes, Direct signaling between platelets and cancer cells induces an epithelial-mesenchymal-like transition and promotes metastasis, Cancer Cell, vol.20, pp.576-590, 2011.

A. Labernadie, A mechanically active heterotypic E-cadherin/N-cadherin adhesion enables fibroblasts to drive cancer cell invasion, Nat. Cell Biol, vol.19, pp.224-237, 2017.

S. Laget, L. Broncy, K. Hormigos, D. M. Dhingra, F. Benmohamed et al., Technical Insights into Highly Sensitive Isolation and Molecular Characterization of Fixed and Live Circulating Tumor Cells for Early Detection of Tumor Invasion, PloS One, vol.12, 2017.

F. Latif, K. Tory, J. Gnarra, M. Yao, F. M. Duh et al., Identification of the von Hippel-Lindau disease tumor suppressor gene, Science, vol.260, pp.1317-1320, 1993.

K. W. Lau, Y. Tian, R. R. Raval, P. J. Ratcliffe, and C. W. Pugh, Target gene selectivity of hypoxia-inducible factor-alpha in renal cancer cells is conveyed by post-DNA-binding mechanisms, Br. J. Cancer, vol.96, pp.1284-1292, 2007.

H. Lee, S. R. Mullins, J. Franco-barraza, M. Valianou, E. Cukierman et al., FAP-overexpressing fibroblasts produce an extracellular matrix that enhances invasive velocity and directionality of pancreatic cancer cells, Prenat. Diagn, vol.11, pp.555-562, 2011.

E. Leonardi, A. Murgia, and S. C. Tosatto, Adding structural information to the von, 2009.

. Hippel-lindau, VHL) tumor suppressor interaction network, FEBS Lett, vol.583, pp.3704-3710

C. Li, D. G. Heidt, P. Dalerba, C. F. Burant, L. Zhang et al.,

D. M. Simeone, Identification of pancreatic cancer stem cells, Cancer Res, vol.67, pp.1030-1037, 2007.

H. Li, S. Ma, J. Huang, X. Chen, and H. Zhou, Roles of long noncoding RNAs in colorectal cancer metastasis, Oncotarget, vol.8, pp.39859-39876, 2017.

J. Li, L. Guo, A. , and Z. , An integrated analysis of cancer genes in clear cell renal cell carcinoma, Future Oncol. Lond. Engl, vol.13, pp.715-725, 2017.

L. Li, Exosomes Derived from Hypoxic Oral Squamous Cell Carcinoma Cells Deliver miR-21 to Normoxic Cells to Elicit a Prometastatic Phenotype, Cancer Res, vol.76, pp.1770-1780, 2016.

Q. Li, J. Xu, W. Wang, X. Cao, Q. Chen et al., Twist1-mediated adriamycin-induced epithelial-mesenchymal transition relates to multidrug resistance and invasive potential in breast cancer cells, Clin. Cancer Res. Off. J. Am, 2009.

. Assoc, Cancer Res, vol.15, pp.2657-2665

Y. Liang, W. Lin, Y. Lin, L. , and J. , , 2015.

L. A. Ligon and E. L. Holzbaur, , 2007.

J. De-ligt, J. A. Veltman, and L. E. Vissers, Point mutations as a source of de novo genetic disease, Curr. Opin. Genet. Dev, vol.23, pp.257-263, 2013.

H. K. Lin, Portable filter-based microdevice for detection and characterization of circulating tumor cells, Clin. Cancer Res. Off. J. Am. Assoc. Cancer Res, vol.16, pp.5011-5018, 2010.

N. Linde, G. Fluegen, and J. A. Aguirre-ghiso, The Relationship Between Dormant Cancer Cells and Their Microenvironment, Adv. Cancer Res, vol.132, pp.45-71, 2016.

W. M. Linehan, R. Srinivasan, and L. S. Schmidt, The genetic basis of kidney cancer: a metabolic disease, Nat. Rev. Urol, vol.7, pp.277-285, 2010.

M. Y. Liu, L. Poellinger, and C. L. Walker, Up-regulation of hypoxia-inducible factor 2alpha in renal cell carcinoma associated with loss of Tsc-2 tumor suppressor gene, Cancer Res, vol.63, pp.2675-2680, 2003.

Z. Liu, C. Wang, H. Chen, X. Li, L. Dai et al., Bone metastasis from lung cancer identified by genetic profiling, Oncol. Lett, vol.13, pp.847-850, 2017.

Y. M. Lo, N. Corbetta, P. F. Chamberlain, V. Rai, I. L. Sargent et al., Presence of fetal DNA in maternal plasma and serum, Lancet Lond. Engl, vol.350, pp.485-487, 1997.

L. Lobastova, D. Kraus, A. Glassmann, D. Khan, C. Steinhäuser et al., Collective cell migration of thyroid carcinoma cells: a beneficial ability to override unfavourable substrates, Cell. Oncol. Dordr, vol.40, pp.63-76, 2017.

E. Long, High expression of TRF2, SOX10, and CD10 in circulating tumor microemboli detected in metastatic melanoma patients. A potential impact for the assessment of disease aggressiveness, Cancer Med, vol.5, pp.1022-1030, 2016.

J. I. López, Renal tumors with clear cells. A review, Pathol. Res. Pract, vol.209, pp.137-146, 2013.

A. Lopez-beltran, M. Scarpelli, R. Montironi, and Z. Kirkali, 2004 WHO classification of the renal tumors of the adults, Eur. Urol, vol.49, pp.798-805, 2006.

X. Lou, J. Sun, S. Gong, X. Yu, R. Gong et al., Interaction between circulating cancer cells and platelets: clinical implication, Chin. J. Cancer Res, 2015.

, Cheng Yen Chiu, vol.27, pp.450-460

X. Lu, C. H. Yan, M. Yuan, Y. Wei, G. Hu et al., In vivo dynamics and distinct functions of hypoxia in primary tumor growth and organotropic metastasis of breast cancer, 2010.

, Cancer Res, vol.70, pp.3905-3914

Y. Lu, L. Yang, W. Wei, and Q. Shi, Microchip-based single-cell functional proteomics for biomedical applications, Lab. Chip, vol.17, pp.1250-1263, 2017.

Z. Lu, S. Ghosh, Z. Wang, and T. Hunter, Downregulation of caveolin-1 function by EGF leads to the loss of E-cadherin, increased transcriptional activity of beta-catenin, and enhanced tumor cell invasion, Cancer Cell, vol.4, pp.499-515, 2003.

Z. Lu, G. Jiang, P. Blume-jensen, and T. Hunter, Epidermal growth factor-induced tumor cell invasion and metastasis initiated by dephosphorylation and downregulation of focal adhesion kinase, Mol. Cell. Biol, vol.21, pp.4016-4031, 2001.

I. A. Lubensky, J. R. Gnarra, P. Bertheau, M. M. Walther, W. M. Linehan et al., Allelic deletions of the VHL gene detected in multiple microscopic clear cell renal lesions in von Hippel-Lindau disease patients, Am. J. Pathol, vol.149, pp.2089-2094, 1996.

I. A. Lubensky, L. Schmidt, Z. Zhuang, G. Weirich, S. Pack et al., Hereditary and sporadic papillary renal carcinomas with c-met mutations share a distinct morphological phenotype, Am. J. Pathol, vol.155, pp.517-526, 1999.

F. A. Mack, W. K. Rathmell, A. M. Arsham, J. Gnarra, B. Keith et al., Loss of pVHL is sufficient to cause HIF dysregulation in primary cells but does not promote tumor growth, 2003.

S. Makino, Further evidence favoring the concept of the stem cell in ascites tumors of rats, 1956.

, Ann. N. Y. Acad. Sci, vol.63, pp.818-830

N. Malara, , 2016.

, J. Transl. Med, vol.14, p.133

E. Maltepe, A. I. Bakardjiev, and S. J. Fisher, The placenta: transcriptional, epigenetic, and physiological integration during development, J. Clin. Invest, vol.120, pp.1016-1025, 2010.

P. Manca, F. Pantano, M. Iuliani, G. Ribelli, D. De-lisi et al., Determinants of bone specific metastasis in prostate cancer, 2017.

, Crit. Rev. Oncol. Hematol, vol.112, pp.59-66

S. J. Mandriota, HIF activation identifies early lesions in VHL kidneys: evidence for site-specific tumor suppressor function in the nephron, Cancer Cell, vol.1, pp.459-468, 2002.

A. J. Maniotis, R. Folberg, A. Hess, E. A. Seftor, L. M. Gardner et al., Vascular channel formation by human melanoma cells in vivo and in vitro: vasculogenic mimicry, Am. J. Pathol, vol.155, pp.739-752, 1999.

A. Mantovani, P. Allavena, A. Sica, and F. Balkwill, Cancer-related inflammation, Nature, vol.454, pp.436-444, 2008.

D. Mantzaris and D. S. Cram, Potential of syncytiotrophoblasts isolated from the cervical mucus for early non-invasive prenatal diagnosis: evidence of a vanishing twin, Clin. Chim. Acta Int, 2015.

, J. Clin. Chem, vol.438, pp.309-315

J. K. Maranchie and Y. Zhan, Nox4 is critical for hypoxia-inducible factor 2-alpha transcriptional activity in von Hippel-Lindau-deficient renal cell carcinoma, Cancer Res, vol.65, pp.9190-9193, 2005.

G. Martello, A MicroRNA targeting dicer for metastasis control, Cell, vol.141, pp.1195-1207, 2010.

A. Marusyk, D. P. Tabassum, P. M. Altrock, V. Almendro, F. Michor et al., Noncell-autonomous driving of tumour growth supports sub-clonal heterogeneity, Nature, vol.514, pp.54-58, 2014.

T. Mazor, A. Pankov, J. S. Song, and J. F. Costello, Intratumoral Heterogeneity of the Epigenome, Cancer Cell, vol.29, pp.440-451, 2016.

W. J. Mccracken, On the diagnosis of various malignancies by Papanicolaou smear, 1948.

, J. Med. Technol, vol.10, pp.114-117

R. J. Medina, Endothelial Progenitors: A Consensus Statement on Nomenclature, p.251, 2017.
URL : https://hal.archives-ouvertes.fr/hal-01777824

, Stem Cells Transl. Med, vol.6, pp.1316-1320

M. Mego, Expression of epithelial-mesenchymal transition-inducing transcription factors in primary breast cancer: The effect of neoadjuvant therapy, Int. J. Cancer, vol.130, pp.808-816, 2012.

G. Meinhardt, P. Husslein, and M. Knöfler, Tissue-specific and ubiquitous basic helix-loophelix transcription factors in human placental trophoblasts, Placenta, vol.26, pp.527-539, 2005.

J. Mejlvang, M. Kriajevska, C. Vandewalle, T. Chernova, A. E. Sayan et al., Direct repression of cyclin D1 by SIP1 attenuates cell cycle progression in cells undergoing an epithelial mesenchymal transition, Mol. Biol. Cell, vol.18, pp.4615-4624, 2007.

M. Miettinen and J. F. Fetsch, Distribution of keratins in normal endothelial cells and a spectrum of vascular tumors: implications in tumor diagnosis, Hum. Pathol, vol.31, pp.1062-1067, 2000.

F. Miller, A. Kentsis, R. Osman, and Z. Pan, Inactivation of VHL by tumorigenic mutations that disrupt dynamic coupling of the pVHL.hypoxia-inducible transcription factor-1alpha complex, J. Biol. Chem, vol.280, pp.7985-7996, 2005.

A. Mirzaei, G. Tavoosidana, M. H. Modarressi, A. A. Rad, M. S. Fazeli et al., Upregulation of circulating cancer stem cell marker, DCLK1 but not Lgr5, in chemoradiotherapy-treated colorectal cancer patients, Tumour Biol. J. Int. Soc, 2015.
DOI : 10.1007/s13277-015-3132-9

, Oncodevelopmental Biol. Med, vol.36, pp.4801-4810

D. O. Miteva, J. M. Rutkowski, J. B. Dixon, W. Kilarski, J. D. Shields et al., , 2010.

, Transmural flow modulates cell and fluid transport functions of lymphatic endothelium, Circ. Res, vol.106, pp.920-931

D. T. Miyamoto, D. T. Ting, M. Toner, S. Maheswaran, and D. A. Haber, Single-Cell Analysis of Circulating Tumor Cells as a Window into Tumor Heterogeneity, 2016.

, Symp. Quant. Biol, vol.81, pp.269-274

H. Moch, An overview of renal cell cancer: pathology and genetics, Semin. Cancer Biol, vol.23, pp.3-9, 2013.

M. Montani, K. Heinimann, A. Von-teichman, T. Rudolph, A. Perren et al., VHLgene deletion in single renal tubular epithelial cells and renal tubular cysts: further evidence for a cyst-dependent progression pathway of clear cell renal carcinoma, 2010.

, Am. J. Surg. Pathol, vol.34, pp.806-815

D. M. Morales-prieto, W. Chaiwangyen, S. Ospina-prieto, U. Schneider, J. Herrmann et al., MicroRNA expression profiles of trophoblastic cells, Placenta, vol.33, p.725, 2012.

K. L. Morris, Circulating biomarkers in hepatocellular carcinoma, Cancer Chemother. Pharmacol, vol.74, pp.323-332, 2014.

C. J. Morrow, Tumourigenic non-small-cell lung cancer mesenchymal circulating tumour cells: a clinical case study, Ann. Oncol. Off. J. Eur. Soc. Med. Oncol, vol.27, pp.1155-1160, 2016.

H. Mouawia, A. Saker, J. Jais, A. Benachi, L. Bussières et al., , 2012.

F. Aubin, . Lucile, E. A. Mroz, R. , and J. W. , The challenges of tumor genetic diversity, Cancer, vol.123, p.917, 2017.

K. Nabeshima, T. Inoue, Y. Shimao, and T. Sameshima, Matrix metalloproteinases in tumor invasion: role for cell migration, Pathol. Int, vol.52, pp.255-264, 2002.

M. Nakayama and P. Berger, Coordination of VEGF receptor trafficking and signaling by coreceptors, Exp. Cell Res, vol.319, pp.1340-1347, 2013.

A. M. Nargund, The SWI/SNF Protein PBRM1 Restrains VHL-Loss-Driven Clear Cell Renal Cell Carcinoma, Cell Rep, vol.18, pp.2893-2906, 2017.

O. E. Nekrasova, E. V. Amargo, W. O. Smith, J. Chen, G. E. Kreitzer et al., , 2011.

, Desmosomal cadherins utilize distinct kinesins for assembly into desmosomes, J. Cell Biol, vol.195, pp.1185-1203

I. Nel, T. C. Gauler, K. Bublitz, L. Lazaridis, A. Goergens et al., Circulating Tumor Cell Composition in Renal Cell Carcinoma, PloS One, vol.11, 2016.

M. L. Nickerson, Improved identification of von Hippel-Lindau gene alterations in clear cell renal tumors, Clin. Cancer Res. Off. J. Am. Assoc. Cancer Res, vol.14, pp.4726-4734, 2008.

M. A. Nieto, The ins and outs of the epithelial to mesenchymal transition in health and disease, Annu. Rev. Cell Dev. Biol, vol.27, pp.347-376, 2011.

J. Nieva, High-definition imaging of circulating tumor cells and associated cellular events in non-small cell lung cancer patients: a longitudinal analysis, Phys. Biol, vol.9, p.16004, 2012.

P. C. Nowell, The clonal evolution of tumor cell populations, Science, vol.194, pp.23-28, 1976.
DOI : 10.1126/science.959840

C. A. O'brien, A. Pollett, S. Gallinger, D. , and J. E. , A human colon cancer cell capable of initiating tumour growth in immunodeficient mice, Nature, vol.445, pp.106-110, 2007.

A. Onaindia, L. J. Medeiros, P. , and K. P. , Clinical utility of recently identified diagnostic, prognostic, and predictive molecular biomarkers in mature B-cell neoplasms, Mod. Pathol. Off. J. U. S. Can. Acad, 2017.
DOI : 10.1038/modpathol.2017.58

C. B. Oudejans, M. L. Tjoa, B. A. Westerman, M. A. Mulders, I. J. Van-wijk et al., Circulating trophoblast in maternal blood, Prenat. Diagn, vol.23, pp.111-116, 2003.
DOI : 10.1002/pd.539

W. Ouyang, Z. Yu, X. Zhao, S. Lu, W. et al., Aptamers in hematological malignancies and their potential therapeutic implications, Crit. Rev. Oncol. Hematol, vol.106, pp.108-117, 2016.
DOI : 10.1016/j.critrevonc.2016.08.003

S. Paget, THE DISTRIBUTION OF SECONDARY GROWTHS IN CANCER OF THE BREAST, 1889.

, The Lancet, vol.133, pp.571-573

A. L. Paguirigan, J. Smith, S. Meshinchi, M. Carroll, C. Maley et al., Singlecell genotyping demonstrates complex clonal diversity in acute myeloid leukemia, Sci. Transl. Med, vol.7, pp.281-283, 2015.

E. Pailler, Detection of circulating tumor cells harboring a unique ALK rearrangement in ALK-positive non-small-cell lung cancer, J. Clin. Oncol. Off. J. Am. Soc. Clin. Oncol, vol.31, p.2273, 2013.

F. Aubin, . Lucile, and E. Pailler, High level of chromosomal instability in circulating tumor cells of ROS1rearranged non-small-cell lung cancer, Ann. Oncol. Off. J. Eur. Soc. Med. Oncol, vol.26, pp.1408-1415, 2015.

M. Pan, H. Chang, Y. Wu, C. Huang, H. et al., Tubocapsanolide A inhibits transforming growth factor-beta-activating kinase 1 to suppress NF-kappaB-induced CCR7, 2009.

, J. Biol. Chem, vol.284, pp.2746-2754

Q. Pan, A prenatal case with discrepant findings between non-invasive prenatal testing and fetal genetic testings, Mol. Cytogenet, vol.7, p.48, 2014.

K. Pantel, E. Denève, D. Nocca, A. Coffy, J. Vendrell et al., , 2012.

, Chem, vol.58, pp.936-940

S. Park, R. R. Ang, S. P. Duffy, J. Bazov, K. N. Chi et al., , 2014.

W. Park and T. Eisen, Prognostic factors in renal cell cancer, BJU Int, vol.99, pp.1277-1281, 2007.

H. Parmar and G. R. Cunha, Epithelial-stromal interactions in the mouse and human mammary gland in vivo, Endocr. Relat. Cancer, vol.11, pp.437-458, 2004.

S. A. Patel and M. C. Simon, Biology of hypoxia-inducible factor-2alpha in development and disease, Cell Death Differ, vol.15, pp.628-634, 2008.

P. Paterlini-bréchot, Circulating Tumor Cells: Who is the Killer? Cancer Microenviron, Off. J, 2014.

. Int, Cancer Microenviron. Soc, vol.7, pp.161-176

J. M. Pawelek and A. K. Chakraborty, Fusion of tumour cells with bone marrow-derived cells: a unifying explanation for metastasis, Nat. Rev. Cancer, vol.8, pp.377-386, 2008.

F. Peglion, F. Llense, E. , and S. , Adherens junction treadmilling during collective migration, Nat. Cell Biol, vol.16, pp.639-651, 2014.

J. Pei, M. M. Feder, T. Al-saleem, Z. Liu, A. Liu et al., Combined classical cytogenetics and microarray-based genomic copy number analysis reveal frequent 3;5 rearrangements in clear cell renal cell carcinoma, Genes. Chromosomes Cancer, vol.49, pp.610-619, 2010.

H. Peinado, Melanoma exosomes educate bone marrow progenitor cells toward a pro-metastatic phenotype through MET, Nat. Med, vol.18, pp.883-891, 2012.

C. Peitzsch, A. Tyutyunnykova, K. Pantel, and A. Dubrovska, Cancer stem cells: The root of tumor recurrence and metastases, Semin. Cancer Biol, vol.44, pp.10-24, 2017.

M. Penet, S. Kakkad, A. P. Pathak, B. Krishnamachary, Y. Mironchik et al., Structure and Function of a Prostate Cancer Dissemination-Permissive Extracellular Matrix, Clin. Cancer Res. Off. J. Am. Assoc. Cancer Res, vol.23, pp.2245-2254, 2017.

J. M. Perkel, Single-cell sequencing made simple, Nature, vol.547, pp.125-126, 2017.

B. L. Petrella, J. Lohi, and C. E. Brinckerhoff, , vol.24, pp.1043-1052, 2005.

I. Pfeifer, Cervical trophoblasts for non-invasive single-cell genotyping and prenatal diagnosis, Placenta, vol.37, pp.56-60, 2016.

K. G. Phillips, The thrombotic potential of circulating tumor microemboli: computational modeling of circulating tumor cell-induced coagulation, Am. J. Physiol. Cell Physiol, vol.308, pp.229-236, 2015.

J. Pierga, C. Bonneton, H. Magdelénat, A. Vincent-salomon, C. Nos et al., Clinical significance of proliferative potential of occult metastatic cells in bone marrow of patients with breast cancer, Br. J. Cancer, vol.89, pp.539-545, 2003.

P. Pinzani, Detection of circulating tumor cells in patients with adrenocortical carcinoma: a monocentric preliminary study, J. Clin. Endocrinol. Metab, vol.98, pp.3731-3738, 2013.

P. Pinzani, B. Salvadori, L. Simi, S. Bianchi, V. Distante et al., Isolation by size of epithelial tumor cells in peripheral blood of patients with breast cancer: correlation with real-time reverse transcriptase-polymerase chain reaction results and feasibility of molecular analysis by laser microdissection, Hum. Pathol, vol.37, pp.711-718, 2006.

M. Pisano, V. Triacca, K. A. Barbee, and M. A. Swartz, An in vitro model of the tumorlymphatic microenvironment with simultaneous transendothelial and luminal flows reveals mechanisms of flow enhanced invasion, Integr. Biol. Quant. Biosci. Nano Macro, vol.7, pp.525-533, 2015.

T. Placke, M. Örgel, M. Schaller, G. Jung, H. Rammensee et al., Platelet-derived MHC class I confers a pseudonormal phenotype to cancer cells that subverts the antitumor reactivity of natural killer immune cells, Cancer Res, vol.72, pp.440-448, 2012.

K. Podsypanina, Y. N. Du, M. Jechlinger, L. J. Beverly, D. Hambardzumyan et al., Seeding and propagation of untransformed mouse mammary cells in the lung, Science, vol.321, pp.1841-1844, 2008.

T. D. Pollard and G. G. Borisy, Cellular motility driven by assembly and disassembly of actin filaments, Cell, vol.112, pp.453-465, 2003.

T. D. Pollard, C. , and J. A. , Actin, a central player in cell shape and movement, Science, vol.326, pp.1208-1212, 2009.

B. Polzer, Molecular profiling of single circulating tumor cells with diagnostic intention, EMBO Mol. Med, vol.6, pp.1371-1386, 2014.

C. P. Ponting, P. L. Oliver, R. , and W. , Evolution and functions of long noncoding RNAs, Cell, vol.136, pp.629-641, 2009.

K. E. Poruk, Circulating Tumor Cell Phenotype Predicts Recurrence and Survival in Pancreatic Adenocarcinoma, Ann. Surg, vol.264, pp.1073-1081, 2016.

T. G. Pretlow, Prostate cancer and other xenografts from cells in peripheral blood of patients, Cancer Res, vol.60, pp.4033-4036, 2000.

D. R. Principe, J. A. Doll, J. Bauer, B. Jung, H. G. Munshi et al., TGF-?: duality of function between tumor prevention and carcinogenesis, p.38, 2014.

P. P. Provenzano, D. R. Inman, K. W. Eliceiri, J. G. Knittel, L. Yan et al., Collagen density promotes mammary tumor initiation and progression, 2008.

, BMC Med, vol.6, p.11

E. A. Punnoose, Evaluation of circulating tumor cells and circulating tumor DNA in non-small cell lung cancer: association with clinical endpoints in a phase II clinical trial of pertuzumab and erlotinib, Clin. Cancer Res. Off. J. Am. Assoc. Cancer Res, vol.18, pp.2391-2401, 2012.

M. Qian, D. C. Wang, H. Chen, and Y. Cheng, Detection of single cell heterogeneity in cancer, Semin. Cell Dev. Biol, vol.64, pp.143-149, 2017.

A. Qiao, F. Gu, X. Guo, X. Zhang, and L. Fu, Breast cancer-associated fibroblasts: their roles in tumor initiation, progression and clinical applications, Front. Med, vol.10, pp.33-40, 2016.

B. Rack, Circulating tumor cells predict survival in early average-to-high risk breast cancer patients, J. Natl. Cancer Inst, vol.106, 2014.

G. Ramos, O. De, L. Bernardi, I. Lauxen, . Sant'ana et al., Fibronectin Modulates Cell Adhesion and Signaling to Promote Single Cell Migration of Highly Invasive Oral Squamous Cell Carcinoma, PloS One, vol.11, 2016.

E. B. Rankin and A. J. Giaccia, The role of hypoxia-inducible factors in tumorigenesis, Cell Death Differ, vol.15, pp.678-685, 2008.

E. B. Rankin, J. E. Tomaszewski, and V. H. Haase, Renal cyst development in mice with conditional inactivation of the von Hippel-Lindau tumor suppressor, Cancer Res, vol.66, pp.2576-2583, 2006.

R. R. Raval, K. W. Lau, M. G. Tran, H. M. Sowter, S. J. Mandriota et al., Contrasting properties of hypoxia-inducible factor 1 (HIF-1) and HIF-2 in von Hippel-Lindau-associated renal cell carcinoma, Mol. Cell. Biol, vol.25, pp.5675-5686, 2005.

C. Razafinjatovo, S. Bihr, A. Mischo, U. Vogl, M. Schmidinger et al., Characterization of VHL missense mutations in sporadic clear cell renal cell carcinoma: hotspots, affected binding domains, functional impact on pVHL and therapeutic relevance, BMC Cancer, vol.16, p.638, 2016.

C. F. Razafinjatovo, D. Stiehl, E. Deininger, M. Rechsteiner, H. Moch et al., , 2017.

J. D. Reed and R. F. Chesley, The routine use of Papanicolaou vaginal smears in gynecologic practice, Bull. Margaret Hague Matern. Hosp. Jersey City NJ, vol.1, pp.104-106, 1948.

M. Reffay, M. C. Parrini, O. Cochet-escartin, B. Ladoux, A. Buguin et al., Interplay of RhoA and mechanical forces in collective cell migration driven by leader cells, Nat. Cell Biol, vol.16, pp.217-223, 2014.
DOI : 10.1038/ncb2917

URL : https://hal.archives-ouvertes.fr/hal-00992150

N. Reymond, B. B. Água, and A. J. Ridley, Crossing the endothelial barrier during metastasis, Nat. Rev. Cancer, vol.13, pp.858-870, 2013.
DOI : 10.1038/nrc3628

A. D. Rhim, EMT and dissemination precede pancreatic tumor formation, Cell, vol.148, pp.349-361, 2012.
DOI : 10.1016/j.cell.2011.11.025

URL : https://doi.org/10.1016/j.cell.2011.11.025

L. Ricci-vitiani, Tumour vascularization via endothelial differentiation of glioblastoma stem-like cells, Nature, vol.468, pp.824-828, 2010.
DOI : 10.1038/nature09557

J. Roe, H. Kim, S. Lee, S. Kim, E. Cho et al., p53 stabilization and transactivation by a von Hippel-Lindau protein, Mol. Cell, vol.22, pp.395-405, 2006.
DOI : 10.1016/j.molcel.2006.04.006

URL : https://doi.org/10.1016/j.molcel.2006.04.006

J. Rossant and J. C. Cross, Placental development: lessons from mouse mutants, 2001.
DOI : 10.1038/35080570

, Rev. Genet, vol.2, pp.538-548

A. Roth, Clonal genotype and population structure inference from single-cell tumor sequencing, Nat. Methods, vol.13, pp.573-576, 2016.

Z. M. Ruggeri, Platelet adhesion under flow, vol.16, pp.58-83, 1994.
DOI : 10.1080/10739680802651477

URL : http://europepmc.org/articles/pmc3057446?pdf=render

J. Runge, T. E. Reichert, A. Fritsch, J. Käs, J. Bertolini et al., Evaluation of single-cell biomechanics as potential marker for oral squamous cell carcinomas: a pilot study, Oral Dis, vol.20, pp.120-127, 2014.

F. Sabeh, R. Shimizu-hirota, and S. J. Weiss, Protease-dependent versus-independent cancer cell invasion programs: three-dimensional amoeboid movement revisited, J. Cell Biol, vol.185, pp.11-19, 2009.
DOI : 10.1083/jcb.200807195

URL : http://jcb.rupress.org/content/185/1/11.full.pdf

A. Saker, A. Benachi, J. P. Bonnefont, A. Munnich, Y. Dumez et al., Genetic characterisation of circulating fetal cells allows non-invasive prenatal diagnosis of cystic fibrosis, Prenat. Diagn, vol.26, pp.906-916, 2006.

A. J. Salsbury, The significance of the circulating cancer cell, Cancer Treat. Rev, vol.2, pp.55-72, 1975.

Y. Sato, Integrated molecular analysis of clear-cell renal cell carcinoma, Nat. Genet, vol.45, pp.860-867, 2013.

N. Saucedo-zeni, , 2012.

, Oncol, vol.41, pp.1241-1250

H. I. Scher, Circulating tumor cell biomarker panel as an individual-level surrogate for survival in metastatic castration-resistant prostate cancer, J. Clin. Oncol. Off. J. Am. Soc. Clin, 2015.

, Oncol, vol.33, pp.1348-1355

H. I. Scher, Association of AR-V7 on Circulating Tumor Cells as a Treatment-Specific Biomarker With Outcomes and Survival in Castration-Resistant Prostate Cancer, JAMA Oncol, vol.2, pp.1441-1449, 2016.

J. M. Schlütter, I. Kirkegaard, A. S. Ferreira, L. Hatt, B. Christensen et al., , p.257

F. Aubin and B. N. Lucile, The Number of Endovascular Trophoblasts in Maternal Blood Increases Overnight and after Physical Activity: An Experimental Study, Fetal Diagn. Ther, vol.40, pp.54-58, 2016.

J. Schrader, T. T. Gordon-walker, R. L. Aucott, M. Van-deemter, A. Quaas et al., Matrix stiffness modulates proliferation, chemotherapeutic response, and dormancy in hepatocellular carcinoma cells, Hepatol. Baltim. Md, vol.53, pp.1192-1205, 2011.

P. Schraml, K. Struckmann, F. Hatz, S. Sonnet, C. Kully et al., VHL mutations and their correlation with tumour cell proliferation, microvessel density, and patient prognosis in clear cell renal cell carcinoma, J. Pathol, vol.196, p.186, 2002.

D. Schumacher, B. Strilic, K. K. Sivaraj, N. Wettschureck, and S. Offermanns, Plateletderived nucleotides promote tumor-cell transendothelial migration and metastasis via P2Y2 receptor, Cancer Cell, vol.24, pp.130-137, 2013.

S. H. Seal, , 1956.

S. H. Seal, Silicone flotation: a simple quantitative method for the isolation of free-floating cancer cells from the blood, Cancer, vol.12, pp.590-595, 1959.

S. H. Seal, A SIEVE FOR THE ISOLATION OF CANCER CELLS AND OTHER LARGE CELLS FROM THE BLOOD, Cancer, vol.17, pp.637-642, 1964.

W. Shan, Y. Jiang, H. Yu, Q. Huang, L. Liu et al., HDAC2 overexpression correlates with aggressive clinicopathological features and DNAdamage response pathway of breast cancer, Am. J. Cancer Res, vol.7, pp.1213-1226, 2017.

Y. Shimono, Downregulation of miRNA-200c links breast cancer stem cells with normal stem cells, Cell, vol.138, pp.592-603, 2009.

T. Shuin, K. Kondo, S. Torigoe, T. Kishida, Y. Kubota et al., Frequent somatic mutations and loss of heterozygosity of the von, 1994.

, Hippel-Lindau tumor suppressor gene in primary human renal cell carcinomas, Cancer Res, vol.54, pp.2852-2855

R. L. Siegel, K. D. Miller, J. , and A. , Cancer statistics, vol.65, pp.5-29, 2015.

S. Sifakis, S. Ghatpande, A. Seppo, M. W. Kilpatrick, T. Tafas et al., Prenatal diagnosis of trisomy 21 through detection of trophoblasts in cervical smears, Early Hum. Dev, vol.86, pp.311-313, 2010.

S. K. Singh, C. Hawkins, I. D. Clarke, J. A. Squire, J. Bayani et al., Identification of human brain tumour initiating cells, Nature, vol.432, pp.396-401, 2004.

E. Sinkala, Profiling protein expression in circulating tumour cells using microfluidic western blotting, Nat. Commun, vol.8, p.14622, 2017.

S. Sluysmans, E. Vasileva, D. Spadaro, J. Shah, F. Rouaud et al., , 2017.

G. Söhl, W. , and K. , Gap junctions and the connexin protein family, Cardiovasc. Res, vol.62, pp.228-232, 2004.

Y. Song, T. Tian, Y. Shi, W. Liu, Y. Zou et al., , 2017.

, Enrichment and single-cell analysis of circulating tumor cells, Chem. Sci, vol.8, pp.1736-1751

M. S. Sosa, P. Bragado, and J. A. Aguirre-ghiso, Mechanisms of disseminated cancer cell dormancy: an awakening field, Nat. Rev. Cancer, vol.14, pp.611-622, 2014.

B. Soygur, M. , and H. , Expression of Syncytin 1 (HERV-W), in the preimplantation human blastocyst, embryonic stem cells and trophoblast cells derived in vitro, Hum. Reprod. Oxf, 2016.

. Engl, , vol.31, pp.1455-1461

S. A. Stacker, M. G. Achen, L. Jussila, M. E. Baldwin, A. et al., Lymphangiogenesis and cancer metastasis, Nat. Rev. Cancer, vol.2, pp.573-583, 2002.

K. Stamatiou, K. Polizois, G. Kollaitis, S. Dahanis, G. Zafeiropoulos et al., Cystic nephroma: a case report and review of the literature, Cases J, vol.1, p.267, 2008.

C. E. Stebbins, W. G. Kaelin, and N. P. Pavletich, Structure of the VHL-ElonginC-ElonginB complex: implications for VHL tumor suppressor function, Science, vol.284, pp.455-461, 1999.

B. N. Stillman, D. K. Hsu, M. Pang, C. F. Brewer, P. Johnson et al., Galectin-3 and galectin-1 bind distinct cell surface glycoprotein receptors to induce T cell death, J. Immunol. Baltim. Md, vol.176, pp.778-789, 1950.

C. Strell and F. Entschladen, Extravasation of leukocytes in comparison to tumor cells, 2008.

, Cell Commun. Signal. CCS, vol.6, p.10

C. Strell, K. Lang, B. Niggemann, K. S. Zaenker, and F. Entschladen, Surface molecules regulating rolling and adhesion to endothelium of neutrophil granulocytes and MDA-MB-468 breast carcinoma cells and their interaction, Cell. Mol. Life Sci. CMLS, vol.64, pp.3306-3316, 2007.

T. Sugino, T. Yamaguchi, G. Ogura, A. Saito, T. Hashimoto et al., Morphological evidence for an invasion-independent metastasis pathway exists in multiple human cancers, BMC Med, vol.2, p.9, 2004.

H. Sun, Anti-angiogenic treatment promotes triple-negative breast cancer invasion via vasculogenic mimicry, Cancer Biol. Ther, vol.18, pp.205-213, 2017.

M. L. Suvà, Reconstructing and reprogramming the tumor-propagating potential of glioblastoma stem-like cells, Cell, vol.157, pp.580-594, 2014.

V. Swaminathan, K. Mythreye, E. T. O'brien, A. Berchuck, G. C. Blobe et al.,

A. Tabor, A. , and Z. , Update on procedure-related risks for prenatal diagnosis techniques, Fetal Diagn. Ther, vol.27, pp.1-7, 2010.

K. Takahashi, Y. , and S. , , 2006.

S. Takaishi, T. Okumura, S. Tu, S. S. Wang, W. Shibata et al., Identification of gastric cancer stem cells using the cell surface marker CD44, Stem Cells Dayt. Ohio, vol.27, pp.1006-1020, 2009.

A. H. Talasaz, Isolating highly enriched populations of circulating epithelial cells and other rare cells from blood using a magnetic sweeper device, Proc. Natl. Acad. Sci. U. S. A, vol.106, pp.3970-3975, 2009.

F. Teng, W. Tian, Y. Wang, Y. Zhang, F. Guo et al., , 2016.

, Cancer-associated fibroblasts promote the progression of endometrial cancer via the SDF-1/CXCR4

, J. Hematol. Oncol.J Hematol Oncol, vol.9

D. M. Tennenbaum, , 2017.

B. Terris, C. Cavard, P. , and C. , EpCAM, a new marker for cancer stem cells in hepatocellular carcinoma, J. Hepatol, vol.52, pp.280-281, 2010.

M. Tewes, B. Aktas, A. Welt, S. Mueller, S. Hauch et al., , 2009.

, Molecular profiling and predictive value of circulating tumor cells in patients with metastatic breast cancer: an option for monitoring response to breast cancer related therapies, Breast Cancer Res

. Treat, , vol.115, pp.581-590

R. Thapa, W. , and G. D. , The Importance of CD44 as a Stem Cell Biomarker and Therapeutic Target in Cancer, Stem Cells Int, 2016.

J. Thiele, K. Bethel, M. Králí?ková, and P. Kuhn, Circulating Tumor Cells: Fluid Surrogates of Solid Tumors, Annu. Rev. Pathol, vol.12, pp.419-447, 2017.

J. P. Thiery, H. Acloque, R. Y. Huang, and M. A. Nieto, Epithelial-mesenchymal transitions in development and disease, Cell, vol.139, pp.871-890, 2009.

V. L. Thijssen, F. Poirier, L. G. Baum, and A. W. Griffioen, Galectins in the tumor endothelium: opportunities for combined cancer therapy, Blood, vol.110, pp.2819-2827, 2007.
URL : https://hal.archives-ouvertes.fr/hal-00193653

I. Tinhofer, M. Saki, F. Niehr, U. Keilholz, and V. Budach, Cancer stem cell characteristics of circulating tumor cells, Int. J. Radiat. Biol, vol.90, pp.622-627, 2014.

I. Tirosh, Dissecting the multicellular ecosystem of metastatic melanoma by singlecell RNA-seq, Science, vol.352, pp.189-196, 2016.

C. Trapnell, Defining cell types and states with single-cell genomics, Genome Res, vol.25, pp.1491-1498, 2015.

P. Tremblay, J. Huot, and F. A. Auger, Mechanisms by which E-selectin regulates diapedesis of colon cancer cells under flow conditions, Cancer Res, vol.68, pp.5167-5176, 2008.

T. Tsuji, S. Ibaragi, K. Shima, M. G. Hu, M. Katsurano et al., , 2008.

K. J. Turner, Expression of hypoxia-inducible factors in human renal cancer: relationship to angiogenesis and to the von Hippel-Lindau gene mutation, Cancer Res, vol.62, p.2957, 2002.

H. Uechi and E. Kuranaga, Mechanisms of collective cell movement lacking a leading or free front edge in vivo, Cell. Mol. Life Sci. CMLS, 2017.

S. Uga, S. Ikeda, S. Matsukage, and M. Hamada, , 2012.

T. Vallenius, Actin stress fibre subtypes in mesenchymal-migrating cells, Open Biol, vol.3, p.130001, 2013.

I. Varela, Exome sequencing identifies frequent mutation of the SWI/SNF complex gene PBRM1 in renal carcinoma, Nature, vol.469, pp.539-542, 2011.

S. Vega, A. V. Morales, O. H. Ocaña, F. Valdés, I. Fabregat et al., Snail blocks the cell cycle and confers resistance to cell death, Genes Dev, vol.18, pp.1131-1143, 2004.

J. Velez, Platelets promote mitochondrial uncoupling and resistance to apoptosis in leukemia cells: a novel paradigm for the bone marrow microenvironment, Cancer Microenviron, 2014.

, Off. J. Int. Cancer Microenviron. Soc, vol.7, pp.79-90

E. Viadana, R. Cotter, J. W. Pickren, and I. D. Bross, An autopsy study of metastatic sites of breast cancer, Cancer Res, vol.33, pp.179-181, 1973.

G. Vona, Isolation by size of epithelial tumor cells : a new method for the immunomorphological and molecular characterization of circulatingtumor cells, Am. J. Pathol, vol.156, pp.57-63, 2000.

C. Vonach, NF-?B mediates the 12(S)-HETE-induced endothelial to mesenchymal transition of lymphendothelial cells during the intravasation of breast carcinoma cells, Br. J. Cancer, vol.105, pp.263-271, 2011.

M. H. Voss, Tumor genetic analyses of patients with metastatic renal cell carcinoma and extended benefit from mTOR inhibitor therapy, Clin. Cancer Res. Off. J. Am. Assoc. Cancer Res, vol.20, pp.1955-1964, 2014.

D. E. Wagner and A. M. Klein, Genetic screening enters the single-cell era, Nat. Methods, vol.14, pp.237-238, 2017.

J. Wang, W. Gan, X. Li, Y. Zhao, Y. Li et al., Orphan nuclear receptor Nur77 promotes colorectal cancer invasion and metastasis by regulating MMP-9 and E-cadherin, Carcinogenesis, vol.35, pp.2474-2484, 2014.

Q. Wang, M. Uhlirova, and D. Bohmann, Spatial restriction of FGF signaling by a matrix metalloprotease controls branching morphogenesis, Dev. Cell, vol.18, pp.157-164, 2010.

S. Wang, Three-dimensional nanostructured substrates toward efficient capture of circulating tumor cells, Angew. Chem. Int. Ed Engl, vol.48, pp.8970-8973, 2009.

S. Wang, Bap1 is essential for kidney function and cooperates with Vhl in renal tumorigenesis, Proc. Natl. Acad. Sci. U. S. A, vol.111, pp.16538-16543, 2014.

T. N. Wang, D. Albo, and G. P. Tuszynski, , 2002.

, Orme aux Merisiers RD 128 / 91190 Saint-Aubin, France Lucile BRONCY by upregulating tumor matrix metalloproteinase-9 production, Surgery, vol.132, pp.220-225

X. Wang, M. Tanaka, S. Krstin, H. S. Peixoto, C. C. Moura et al., , 2016.

, Cytoskeletal interference-A new mode of action for the anticancer drugs camptothecin and topotecan, Eur. J. Pharmacol, vol.789, pp.265-274

D. J. Webb, C. M. Brown, and A. F. Horwitz, Illuminating adhesion complexes in migrating cells: moving toward a bright future, Curr. Opin. Cell Biol, vol.15, pp.614-620, 2003.

M. Weber, C. Göhner, S. San-martin, A. Vattai, S. Hutter et al., Unique trophoblast stem cell-and pluripotency marker staining patterns depending on gestational age and placenta-associated pregnancy complications, Cell Adhes. Migr, vol.10, pp.56-65, 2016.

J. Weitz, P. Kienle, J. Lacroix, F. Willeke, A. Benner et al., Dissemination of tumor cells in patients undergoing surgery for colorectal cancer, Clin. Cancer Res. Off. J. Am. Assoc. Cancer Res, vol.4, pp.343-348, 1998.

W. Wenjun, W. Zhihua, W. Zhuo, D. Yuliang, and S. Qihui, , 2017.

C. W. Wong, C. Song, M. M. Grimes, W. Fu, M. W. Dewhirst et al., Intravascular location of breast cancer cells after spontaneous metastasis to the lung, 2002.

, J. Pathol, vol.161, pp.749-753

J. B. Wyckoff, Y. Wang, E. Y. Lin, J. Li, S. Goswami et al., Direct visualization of macrophage-assisted tumor cell intravasation in mammary tumors, Cancer Res, vol.67, pp.2649-2656, 2007.

W. Xu, R. Mezencev, B. Kim, L. Wang, J. Mcdonald et al., , 2012.

X. Xu, Single-cell exome sequencing reveals single-nucleotide mutation characteristics of a kidney tumor, Cell, vol.148, pp.886-895, 2012.

A. Yadav, B. Kumar, J. Yu, M. Old, T. N. Teknos et al., Tumor-Associated Endothelial Cells Promote Tumor Metastasis by Chaperoning Circulating Tumor Cells and Protecting Them from Anoikis, PloS One, vol.10, p.141602, 2015.

S. Yadavalli, Data-Driven Discovery of Extravasation Pathway in Circulating Tumor Cells, Sci. Rep, vol.7, p.43710, 2017.

B. Yan, Single-cell genomic profiling of acute myeloid leukemia for clinical use: A pilot study, Oncol. Lett, vol.13, pp.1625-1630, 2017.

H. H. Yan, M. Pickup, Y. Pang, A. E. Gorska, Z. Li et al., Gr-1+CD11b+ myeloid cells tip the balance of immune protection to tumor promotion in the premetastatic lung, Cancer Res, vol.70, pp.6139-6149, 2010.

C. Yang, K. Huntoon, A. Ksendzovsky, Z. Zhuang, and R. R. Lonser, Proteostasis modulators prolong missense VHL protein activity and halt tumor progression, Cell Rep, vol.3, pp.52-59, 2013.

Y. H. Yang, S. H. Kim, E. S. Yang, S. K. Kim, I. K. Kim et al., , vol.262

, Prenatal diagnosis of fetal trisomy 21 from maternal peripheral blood, Yonsei Med. J, vol.44, pp.181-186, 2003.

Y. H. Yang, E. S. Yang, J. Y. Kwon, I. K. Kim, and Y. W. Park, Prenatal diagnosis of trisomy 21 with fetal cells in maternal blood using comparative genomic hybridization, 2006.

. Ther, , vol.21, pp.125-133

X. Yao, C. Williamson, V. A. Adalsteinsson, R. S. Agostino, T. Fitton et al., Tumor cells are dislodged into the pulmonary vein during lobectomy, J. Thorac. Cardiovasc. Surg, vol.148, pp.3224-3231, 2014.

Y. Ye, S. Liu, C. Wu, and Z. Sun, TGF? modulates inflammatory cytokines and growth factors to create premetastatic microenvironment and stimulate lung metastasis, J. Mol. Histol, vol.46, pp.365-375, 2015.

J. Yin, Circulating Tumor Cells Enriched by the Depletion of Leukocytes with BiAntibodies in Non-Small Cell Lung Cancer: Potential Clinical Application, PloS One, vol.10, 2015.

B. Yu, X. Dong, S. Gravina, Ö. Kartal, T. Schimmel et al., , 2017.

. Genome-wide, Single-Cell DNA Methylomics Reveals Increased Non-CpG Methylation during Human Oocyte Maturation, Stem Cell Rep

L. Yu, Galectin-3 interaction with Thomsen-Friedenreich disaccharide on cancerassociated MUC1 causes increased cancer cell endothelial adhesion, J. Biol. Chem, vol.282, pp.773-781, 2007.

M. Yu, Circulating breast tumor cells exhibit dynamic changes in epithelial and mesenchymal composition, Science, vol.339, pp.580-584, 2013.

M. Yu, Cancer therapy. Ex vivo culture of circulating breast tumor cells for individualized testing of drug susceptibility, Science, vol.345, pp.216-220, 2014.
URL : https://hal.archives-ouvertes.fr/hal-01948490

P. Yu and T. Kodadek, Dynamics of the hypoxia-inducible factor-1-vascular endothelial growth factor promoter complex, J. Biol. Chem, vol.282, pp.35035-35045, 2007.

T. Yu, Z. Guo, H. Fan, J. Song, Y. Liu et al., , 2016.

G. S. Zamay, Aptamers Selected to Postoperative Lung Adenocarcinoma Detect Circulating Tumor Cells in Human Blood, Mol. Ther. J. Am. Soc. Gene Ther, vol.23, pp.1486-1496, 2015.

J. Zem?a, J. Danilkiewicz, B. Orzechowska, J. Pabijan, S. Seweryn et al., , 2017.

, Atomic force microscopy as a tool for assessing the cellular elasticity and adhesiveness to identify cancer cells and tissues, Semin. Cell Dev. Biol

D. Zhang, L. Zhao, P. Zhou, H. Ma, F. Huang et al., Circulating tumor microemboli (CTM) and vimentin+ circulating tumor cells, 2017.

J. Zhang, X. Qiao, H. Shi, X. Han, W. Liu et al., Circulating tumorassociated neutrophils (cTAN) contribute to circulating tumor cell survival by suppressing peripheral leukocyte activation, Tumour Biol. J. Int. Soc. Oncodevelopmental Biol. Med, vol.37, 2016.

L. Zhang, L. D. Ridgway, M. D. Wetzel, J. Ngo, W. Yin et al., The identification and characterization of breast cancer CTCs competent for brain metastasis, Sci. Transl. Med, vol.5, pp.180-228, 2013.

W. C. Zhang, Glycine decarboxylase activity drives non-small cell lung cancer tumorinitiating cells and tumorigenesis, Cell, vol.148, pp.259-272, 2012.

X. H. Zhang, X. Jin, S. Malladi, Y. Zou, Y. H. Wen et al., Selection of bone metastasis seeds by mesenchymal signals in the primary tumor stroma, Cell, vol.154, pp.1060-1073, 2013.

Y. Zhang, Y. Tao, and Q. Liao, Long noncoding RNA: a crosslink in biological regulatory network, Brief. Bioinform, 2017.

Y. Zhang, H. Thayele-purayil, J. B. Black, F. Fetto, L. D. Lynch et al., Prostaglandin E2 receptor 4 mediates renal cell carcinoma intravasation and metastasis, 2017.

, Cancer Lett, vol.391, pp.50-58

C. Zhao, S. Hu, X. Huo, and Y. Zhang, Dr.seq2: A quality control and analysis pipeline for parallel single cell transcriptome and epigenome data, PloS One, vol.12, 2017.
URL : https://hal.archives-ouvertes.fr/insu-01677929

C. Zhao, J. Tynan, M. Ehrich, G. Hannum, R. Mccullough et al., Detection of fetal subchromosomal abnormalities by sequencing circulating cell-free DNA from maternal plasma, Clin. Chem, vol.61, pp.608-616, 2015.

L. Zhao, High-purity prostate circulating tumor cell isolation by a polymer nanofiberembedded microchip for whole exome sequencing, Adv. Mater. Deerfield Beach Fla, vol.25, p.2897, 2013.

M. Zhao, L. Ang, J. Huang, W. , and J. , MicroRNAs regulate the epithelialmesenchymal transition and influence breast cancer invasion and metastasis, Tumour Biol. J. Int, 2017.

, Soc. Oncodevelopmental Biol. Med, vol.39, p.1010428317691682

C. Zhou, J. Liu, Y. Tang, and X. Liang, Inflammation linking EMT and cancer stem cells, 2012.

, Oral Oncol, vol.48, pp.1068-1075

M. I. Zhou, H. Wang, R. L. Foy, J. J. Ross, and H. T. Cohen, Tumor suppressor von Hippel-Lindau (VHL) stabilization of Jade-1 protein occurs through plant homeodomains and is VHL mutation dependent, Cancer Res, vol.64, pp.1278-1286, 2004.

S. Zhu, T. Qing, Y. Zheng, L. Jin, and L. Shi, Advances in single-cell RNA sequencing and its applications in cancer research, Oncotarget, 2017.

Z. Zhuang, J. R. Gnarra, C. F. Dudley, B. Zbar, W. M. Linehan et al., Detection of von Hippel-Lindau disease gene mutations in paraffin-embedded sporadic renal cell carcinoma specimens, Mod. Pathol. Off. J. U. S. Can. Acad. Pathol. Inc, vol.9, pp.838-842, 1996.

J. Zuo, Activation of EGFR promotes squamous carcinoma SCC10A cell migration and invasion via inducing EMT-like phenotype change and MMP-9-mediated degradation of Ecadherin, J. Cell. Biochem, vol.112, p.19, 2011.

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. .. Discussion, 11 1.1. Pourquoi et comment récupérer non-invasivement les cellules trophoblastiques du col ?

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D. .. ,

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R. .. Bagheri, V. Razavi, M. S. Momtazi, A. A. Sahebkar, A. et al., , 2017.

, Isolation, identification, and characterization of cancer stem cells: A review, J. Cell. Physiol, vol.232, 2008.

C. Abbosh, Phylogenetic ctDNA analysis depicts early-stage lung cancer evolution, Nature, vol.545, pp.446-451, 2017.

E. A. Abdallah, MRP1 expression in CTCs confers resistance to irinotecan-based chemotherapy in metastatic colorectal cancer, Int. J. Cancer, vol.139, pp.890-898, 2016.

M. Adinolfi and J. Sherlock, Fetal cells in transcervical samples at an early stage of gestation, 2001.

, Hum. Genet, vol.46, pp.99-104

C. Alix-panabières and K. Pantel, Clinical Applications of Circulating Tumor Cells and Circulating Tumor DNA as Liquid Biopsy, Cancer Discov, vol.6, pp.479-491, 2016.

I. Baccelli, Nat. Biotechnol, vol.31, pp.539-544, 2013.

A. L. Beaudet, Using fetal cells for prenatal diagnosis: History and recent progress, Am. J. Med, 2016.

. Genet and . Semin, Med. Genet, vol.172, pp.123-127

C. Béroud, M. Karliova, J. P. Bonnefont, A. Benachi, A. Munnich et al.,

P. Bréchot, Prenatal diagnosis of spinal muscular atrophy by genetic analysis of circulating fetal cells, 2003.

, Lancet Lond. Engl, vol.361, pp.1013-1014

D. W. Bianchi, G. K. Zickwolf, G. J. Weil, S. Sylvester, and M. A. Demaria, Male fetal progenitor cells persist in maternal blood for as long as 27 years postpartum, Proc. Natl. Acad. Sci. U. S. A, vol.93, p.705, 1996.

F. Bidard, B. Weigelt, and J. S. Reis-filho, Going with the flow: from circulating tumor cells to DNA, Sci. Transl. Med, vol.5, pp.207-221, 2013.

V. Bobek, G. Kacprzak, A. Rzechonek, and K. Kolostova, Detection and cultivation of circulating tumor cells in malignant pleural mesothelioma, Anticancer Res, vol.34, pp.2565-2569, 2014.

J. M. Bolnick, B. A. Kilburn, S. Bajpayee, N. Reddy, R. Jeelani et al., Trophoblast retrieval and isolation from the cervix (TRIC) for noninvasive prenatal screening at 5 to 20 weeks of gestation, Fertil. Steril, vol.102, pp.135-142, 2014.

T. Brabletz, A. Jung, S. Spaderna, F. Hlubek, and T. Kirchner, Opinion: migrating cancer stem cells-an integrated concept of malignant tumour progression, Nat. Rev. Cancer, vol.5, pp.744-749, 2005.

A. M. Breman, Evidence for feasibility of fetal trophoblastic cell-based noninvasive prenatal testing, Prenat. Diagn, vol.36, issue.23, pp.1009-1019, 2016.

F. Aubin, . Lucile, and M. E. Buim, Detection of KRAS mutations in circulating tumor cells from patients with metastatic colorectal cancer, Cancer Biol. Ther, vol.16, pp.1289-1295, 2015.

L. Cabel, C. Proudhon, H. Gortais, D. Loirat, F. Coussy et al., Circulating tumor cells: clinical validity and utility, Int. J. Clin. Oncol, vol.22, pp.421-430, 2017.

A. Calzado-martín, M. Encinar, J. Tamayo, M. Calleja, S. Paulo et al., Effect of Actin Organization on the Stiffness of Living Breast Cancer Cells Revealed by Peak-Force Modulation Atomic Force Microscopy, ACS Nano, vol.10, pp.3365-3374, 2016.

, Comprehensive molecular characterization of clear cell renal cell carcinoma, Cancer Genome Atlas Research Network, vol.499, pp.43-49, 2013.

L. Cayrefourcq, Establishment and characterization of a cell line from human circulating colon cancer cells, Cancer Res, vol.75, pp.892-901, 2015.
URL : https://hal.archives-ouvertes.fr/hal-01990012

L. Cheng, G. T. Maclennan, S. Zhang, M. Wang, M. Zhou et al.,

R. Montironi, Evidence for polyclonal origin of multifocal clear cell renal cell carcinoma, Clin. Cancer Res. Off. J. Am. Assoc. Cancer Res, vol.14, pp.8087-8093, 2008.

S. J. Cohen, Relationship of circulating tumor cells to tumor response, progression-free survival, and overall survival in patients with metastatic colorectal cancer, J. Clin. Oncol. Off. J. Am. Soc, 2008.

, Clin. Oncol, vol.26, pp.3213-3221

M. Cristofanilli, Circulating tumor cells, disease progression, and survival in metastatic breast cancer, N. Engl. J. Med, vol.351, pp.781-791, 2004.

A. M. Czarnecka, A. Kornakiewicz, W. Kukwa, and C. Szczylik, Frontiers in clinical and molecular diagnostics and staging of metastatic clear cell renal cell carcinoma, Future Oncol. Lond. Engl, vol.10, pp.1095-1111, 2014.

J. Dagher, S. Kammerer-jacquet, F. Dugay, M. Beaumont, A. Lespagnol et al., Clear cell renal cell carcinoma: a comparative study of histological and chromosomal characteristics between primary tumors and their corresponding metastases, Virchows Arch. Int. J. Pathol, 2017.
URL : https://hal.archives-ouvertes.fr/hal-01560281

D. C. Danila, Circulating tumor cell number and prognosis in progressive castration-resistant prostate cancer, Clin. Cancer Res. Off. J. Am. Assoc. Cancer Res, vol.13, pp.7053-7058, 2007.

C. Dumontet, J. , and M. A. , Microtubule-binding agents: a dynamic field of cancer therapeutics, 2010.
URL : https://hal.archives-ouvertes.fr/inserm-00526519

, Nat. Rev. Drug Discov, vol.9, pp.790-803

B. H. Faas, J. De-ligt, I. Janssen, A. J. Eggink, L. D. Wijnberger et al., Non-invasive prenatal diagnosis of fetal aneuploidies using massively parallel sequencing-by-ligation and evidence that cell-free fetal DNA in the maternal plasma, p.24, 2012.

, BRONCY cytotrophoblastic cells. Expert Opin. Biol. Ther, vol.12, issue.1, pp.19-26

G. P. Fadini, S. Ciciliot, A. , and M. , Concise Review: Perspectives and Clinical Implications of Bone Marrow and Circulating Stem Cell Defects in Diabetes, Stem Cells Dayt. Ohio, vol.35, pp.106-116, 2017.

F. Farace, A direct comparison of CellSearch and ISET for circulating tumour-cell detection in patients with metastatic carcinomas, Br. J. Cancer, vol.105, pp.847-853, 2011.

V. Faugeroux, E. Pailler, N. Auger, M. Taylor, F. et al., Clinical Utility of Circulating Tumor Cells in ALK-Positive Non-Small, Cell Lung Cancer. Front. Oncol, vol.4, p.281, 2014.

I. J. Fidler, Biological behavior of malignant melanoma cells correlated to their survival in vivo, 1975.

, Cancer Res, vol.35, pp.218-224

I. J. Fidler, The pathogenesis of cancer metastasis: the "seed and soil" hypothesis revisited, 2003.

, Rev. Cancer, vol.3, pp.453-458

D. Gao, Organoid cultures derived from patients with advanced prostate cancer, Cell, vol.159, p.176, 2014.

W. Gao, W. Li, T. Xiao, X. S. Liu, and W. G. Kaelin, Inactivation of the PBRM1 tumor suppressor gene amplifies the HIF-response in VHL-/-clear cell renal carcinoma, Proc. Natl. Acad. Sci. U. S. A, vol.114, pp.1027-1032, 2017.

Y. Gao, Single-cell sequencing deciphers a convergent evolution of copy number alterations from primary to circulating tumour cells, Genome Res, 2017.

M. Gerlinger, Intratumor heterogeneity and branched evolution revealed by multiregion sequencing, N. Engl. J. Med, vol.366, pp.883-892, 2012.

M. Gerlinger, Genomic architecture and evolution of clear cell renal cell carcinomas defined by multiregion sequencing, Nat. Genet, vol.46, pp.225-233, 2014.

M. Gerstung, C. Beisel, M. Rechsteiner, P. Wild, P. Schraml et al., , 2012.

, Reliable detection of subclonal single-nucleotide variants in tumour cell populations, Nat. Commun, vol.3, p.811

J. I. Greenberg, A role for VEGF as a negative regulator of pericyte function and vessel maturation, Nature, vol.456, pp.809-813, 2008.

F. Grillet, , 2016.

J. Guck, Optical deformability as an inherent cell marker for testing malignant transformation and metastatic competence, Biophys. J, vol.88, pp.3689-3698, 2005.

S. Gulati, Systematic evaluation of the prognostic impact and intratumour heterogeneity of clear cell renal cell carcinoma biomarkers, Eur. Urol, vol.66, p.25, 2014.

F. Aubin, . Lucile, R. A. Harouaka, M. Nisic, and S. Zheng, Circulating tumor cell enrichment based on physical properties, J. Lab. Autom, vol.18, pp.455-468, 2013.

K. Hayata, Y. Hiramatsu, H. Masuyama, E. Eto, T. Mitsui et al., Discrepancy between Non-invasive Prenatal Genetic Testing (NIPT) and Amniotic Chromosomal Test due to Placental Mosaicism: A Case Report and Literature Review, Acta Med. Okayama, vol.71, pp.181-185, 2017.

R. L. Heise, P. A. Link, and L. Farkas, From Here to There, Progenitor Cells and Stem Cells Are Everywhere in Lung Vascular Remodeling. Front, 2016.

C. L. Hodgkinson, Tumorigenicity and genetic profiling of circulating tumor cells in small-cell lung cancer, Nat. Med, vol.20, pp.897-903, 2014.

V. Hofman, , 2011.

, Off. J. Am. Assoc. Cancer Res, vol.17, pp.827-835

V. Hofman, , 2012.

, Cytopathol. Off. J. Br. Soc. Clin. Cytol, vol.23, pp.30-38

V. Hofman, Usefulness of immunocytochemistry for the detection of the BRAF(V600E) mutation in circulating tumor cells from metastatic melanoma patients, J. Invest. Dermatol, vol.133, pp.1378-1381, 2013.

V. Hofman, Detection of circulating tumor cells from lung cancer patients in the era of targeted therapy: promises, drawbacks and pitfalls, Curr. Mol. Med, vol.14, pp.440-456, 2014.

V. Hofman, M. I. Ilie, E. Long, E. Selva, C. Bonnetaud et al., Detection of circulating tumor cells as a prognostic factor in patients undergoing radical surgery for non-small-cell lung carcinoma: comparison of the efficacy of the CellSearch Assay TM and the isolation by size of epithelial tumor cell method, Int. J. Cancer, vol.129, pp.1651-1660, 2011.

V. J. Hofman, Cytopathologic detection of circulating tumor cells using the isolation by size of epithelial tumor cell method: promises and pitfalls, Am. J. Clin. Pathol, vol.135, pp.146-156, 2011.

V. J. Hofman, M. Ilie, and P. M. Hofman, Detection and characterization of circulating tumor cells in lung cancer: Why and how? Cancer Cytopathol, vol.124, pp.380-387, 2016.

N. M. Hunkapiller and S. J. Fisher, , 2008.

, Methods Enzymol, vol.445, pp.281-302

Y. Hüsemann, Systemic spread is an early step in breast cancer, Cancer Cell, vol.13, pp.58-68, 2008.

M. Ilie, ALK-gene rearrangement: a comparative analysis on circulating tumour cells and tumour tissue from patients with lung adenocarcinoma, Ann. Oncol. Off. J. Eur. Soc. Med. Oncol, vol.23, p.2907, 2012.

M. Ilie, V. Hofman, E. Long-mira, E. Selva, J. Vignaud et al., Sentinel" circulating tumor cells allow early diagnosis of lung cancer in patients with chronic obstructive pulmonary disease, PloS One, vol.9, 2014.
URL : https://hal.archives-ouvertes.fr/hal-01687052

A. N. Imudia, Y. Suzuki, B. A. Kilburn, F. D. Yelian, M. P. Diamond et al., Retrieval of trophoblast cells from the cervical canal for prediction of abnormal pregnancy: a pilot study, Hum. Reprod. Oxf. Engl, vol.24, pp.2086-2092, 2009.

C. V. Jain, , 2016.

G. Kats-ugurlu, Circulating tumour tissue fragments in patients with pulmonary metastasis of clear cell renal cell carcinoma, J. Pathol, vol.219, pp.287-293, 2009.

E. Kervancioglu-demirci, L. A. Salamonsen, and M. Gauster, The role of CX3CL1 in fetal-maternal interaction during human gestation, Cell Adhes. Migr, vol.10, pp.189-196, 2016.

L. Khoja, A pilot study to explore circulating tumour cells in pancreatic cancer as a novel biomarker, Br. J. Cancer, vol.106, pp.508-516, 2012.

L. Khoja, P. Shenjere, C. Hodgson, J. Hodgetts, G. Clack et al., , 2014.

, Prevalence and heterogeneity of circulating tumour cells in metastatic cutaneous melanoma, Melanoma Res, vol.24, pp.40-46

B. L. Khoo, P. K. Chaudhuri, N. Ramalingam, D. S. Tan, C. T. Lim et al., Singlecell profiling approaches to probing tumor heterogeneity, Int. J. Cancer, vol.139, pp.243-255, 2016.

K. Kim, Application of single-cell RNA sequencing in optimizing a combinatorial therapeutic strategy in metastatic renal cell carcinoma, Genome Biol, vol.17, p.80, 2016.

C. A. Klein, Combined transcriptome and genome analysis of single micrometastatic cells, 2002.

, Biotechnol, vol.20, pp.387-392

C. A. Klein, Parallel progression of primary tumours and metastases, Nat. Rev. Cancer, vol.9, pp.302-312, 2009.

K. Kolostova, Y. Zhang, R. M. Hoffman, and V. Bobek, protein. J. Fluoresc, vol.24, pp.1531-1536, 2014.

S. Kølvraa, , 2016.

, Genome-wide copy number analysis on DNA from fetal cells isolated from the blood of pregnant women, Prenat. Diagn, vol.36, pp.1127-1134

M. G. Krebs, Analysis of circulating tumor cells in patients with non-small cell lung cancer using epithelial marker-dependent and-independent approaches, J. Thorac. Oncol. Off. Publ. Int. Assoc. Study Lung Cancer, vol.7, p.27, 2012.

B. Küsters, G. Kats, I. Roodink, K. Verrijp, P. Wesseling et al., Micronodular transformation as a novel mechanism of VEGF-A, 2007.

, Oncogene, vol.26, pp.5808-5815

F. Latif, K. Tory, J. Gnarra, M. Yao, F. M. Duh et al.,

L. Geil, Identification of the von Hippel-Lindau disease tumor suppressor gene, Science, vol.260, p.1317, 1993.

J. Li, L. Guo, A. , and Z. , An integrated analysis of cancer genes in clear cell renal cell carcinoma, 2017.

, Future Oncol. Lond. Engl, vol.13, pp.715-725

J. De-ligt, J. A. Veltman, and L. E. Vissers, Point mutations as a source of de novo genetic disease, Curr. Opin. Genet. Dev, vol.23, pp.257-263, 2013.

E. Long, High expression of TRF2, SOX10, and CD10 in circulating tumor microemboli detected in metastatic melanoma patients. A potential impact for the assessment of disease aggressiveness, Cancer Med, vol.5, pp.1022-1030, 2016.

J. I. López, Renal tumors with clear cells. A review, Pathol. Res. Pract, vol.209, pp.137-146, 2013.

Y. Lu, L. Yang, W. Wei, and Q. Shi, Microchip-based single-cell functional proteomics for biomedical applications, Lab. Chip, vol.17, pp.1250-1263, 2017.

I. A. Lubensky, L. Schmidt, Z. Zhuang, G. Weirich, S. Pack et al., Hereditary and sporadic papillary renal carcinomas with c-met mutations share a distinct morphological phenotype, Am. J. Pathol, vol.155, pp.517-526, 1999.

N. Malara, Ex-vivo characterization of circulating colon cancer cells distinguished in stem and differentiated subset provides useful biomarker for personalized metastatic risk assessment, J. Transl. Med, vol.14, p.133, 2016.

E. Maltepe, A. I. Bakardjiev, and S. J. Fisher, The placenta: transcriptional, epigenetic, and physiological integration during development, J. Clin. Invest, vol.120, pp.1016-1025, 2010.

S. J. Mandriota, HIF activation identifies early lesions in VHL kidneys: evidence for site-specific tumor suppressor function in the nephron, Cancer Cell, vol.1, pp.459-468, 2002.

D. Mantzaris and D. S. Cram, Potential of syncytiotrophoblasts isolated from the cervical mucus for early non-invasive prenatal diagnosis: evidence of a vanishing twin, Clin. Chim. Acta Int. J. Clin. Chem, vol.438, pp.309-315, 2015.

W. J. Mccracken, On the diagnosis of various malignancies by Papanicolaou smear. Can, J. Med. Technol, vol.10, pp.114-117, 1948.

R. J. Medina, Endothelial Progenitors: A Consensus Statement on Nomenclature, Stem Cells Transl. Med, vol.6, pp.1316-1320, 2017.
URL : https://hal.archives-ouvertes.fr/hal-01777824

F. Aubin, . Lucile, and M. Mego, Expression of epithelial-mesenchymal transition-inducing transcription factors in primary breast cancer: The effect of neoadjuvant therapy, Int. J. Cancer, vol.130, pp.808-816, 2012.

J. Mejlvang, M. Kriajevska, C. Vandewalle, T. Chernova, A. E. Sayan et al., , 2007.

, Mol. Biol. Cell, vol.18, pp.4615-4624

D. T. Miyamoto, D. T. Ting, M. Toner, S. Maheswaran, and D. A. Haber, Single-Cell Analysis of Circulating Tumor Cells as a Window into Tumor Heterogeneity, Cold Spring Harb. Symp. Quant. Biol, vol.81, pp.269-274, 2016.

M. Montani, K. Heinimann, A. Von-teichman, T. Rudolph, A. Perren et al., VHL-gene deletion in single renal tubular epithelial cells and renal tubular cysts: further evidence for a cyst-dependent progression pathway of clear cell renal carcinoma in von Hippel-Lindau disease, Am. J. Surg. Pathol, vol.34, pp.806-815, 2010.

K. L. Morris, Circulating biomarkers in hepatocellular carcinoma, Cancer Chemother, 2014.

. Pharmacol, , vol.74, pp.323-332

C. J. Morrow, Tumourigenic non-small-cell lung cancer mesenchymal circulating tumour cells: a clinical case study, Ann. Oncol. Off. J. Eur. Soc. Med. Oncol, vol.27, pp.1155-1160, 2016.

H. Mouawia, A. Saker, J. Jais, A. Benachi, L. Bussières et al.,

J. L. Simpson and P. Paterlini-brechot, Circulating trophoblastic cells provide genetic diagnosis in 63 fetuses at risk for cystic fibrosis or spinal muscular atrophy, Reprod. Biomed. Online, vol.25, pp.508-520, 2012.

I. Nel, T. C. Gauler, K. Bublitz, L. Lazaridis, A. Goergens et al., Circulating Tumor Cell Composition in Renal Cell Carcinoma, PloS One, vol.11, 2016.

M. A. Nieto, The ins and outs of the epithelial to mesenchymal transition in health and disease, 2011.

, Annu. Rev. Cell Dev. Biol, vol.27, pp.347-376

C. B. Oudejans, M. L. Tjoa, B. A. Westerman, M. A. Mulders, I. J. Van-wijk et al., Circulating trophoblast in maternal blood, Prenat. Diagn, vol.23, pp.111-116, 2003.

E. Pailler, Detection of circulating tumor cells harboring a unique ALK rearrangement in ALKpositive non-small-cell lung cancer, J. Clin. Oncol. Off. J. Am. Soc. Clin. Oncol, vol.31, pp.2273-2281, 2013.

E. Pailler, High level of chromosomal instability in circulating tumor cells of ROS1-rearranged non-small-cell lung cancer, Ann. Oncol. Off. J. Eur. Soc. Med. Oncol, vol.26, pp.1408-1415, 2015.

Q. Pan, A prenatal case with discrepant findings between non-invasive prenatal testing and fetal genetic testings, Mol. Cytogenet, vol.7, p.48, 2014.

K. Pantel, E. Denève, D. Nocca, A. Coffy, J. Vendrell et al.,

C. Panabières, Circulating epithelial cells in patients with benign colon diseases, Clin. Chem, vol.58, 2012.

S. Park, R. R. Ang, S. P. Duffy, J. Bazov, K. N. Chi et al., , 2014.

W. Park and T. Eisen, Prognostic factors in renal cell cancer, BJU Int, vol.99, pp.1277-1281, 2007.

P. Paterlini-bréchot, Circulating Tumor Cells: Who is the Killer? Cancer Microenviron, Off. J. Int, 2014.

, Cancer Microenviron. Soc, vol.7, pp.161-176

I. Pfeifer, Cervical trophoblasts for non-invasive single-cell genotyping and prenatal diagnosis, Placenta, vol.37, pp.56-60, 2016.

P. Pinzani, B. Salvadori, L. Simi, S. Bianchi, V. Distante et al., Isolation by size of epithelial tumor cells in peripheral blood of patients with breast cancer: correlation with real-time reverse transcriptase-polymerase chain reaction results and feasibility of molecular analysis by laser microdissection, Hum. Pathol, vol.37, pp.711-718, 2006.

K. Podsypanina, Y. N. Du, M. Jechlinger, L. J. Beverly, D. Hambardzumyan et al., , 2008.

, Seeding and propagation of untransformed mouse mammary cells in the lung, Science, vol.321, pp.1841-1844

B. Polzer, Molecular profiling of single circulating tumor cells with diagnostic intention, 2014.

, Mol. Med, vol.6, pp.1371-1386

K. E. Poruk, Circulating Tumor Cell Phenotype Predicts Recurrence and Survival in Pancreatic Adenocarcinoma, Ann. Surg, vol.264, pp.1073-1081, 2016.

T. G. Pretlow, Prostate cancer and other xenografts from cells in peripheral blood of patients, 2000.

, Cancer Res, vol.60, pp.4033-4036

M. Qian, D. C. Wang, H. Chen, and Y. Cheng, Detection of single cell heterogeneity in cancer, 2017.

. Semin, Cell Dev. Biol, vol.64, pp.143-149

J. D. Reed and R. F. Chesley, The routine use of Papanicolaou vaginal smears in gynecologic practice, Bull. Margaret Hague Matern. Hosp. Jersey City NJ, vol.1, pp.104-106, 1948.

J. Runge, T. E. Reichert, A. Fritsch, J. Käs, J. Bertolini et al., Evaluation of single-cell biomechanics as potential marker for oral squamous cell carcinomas: a pilot study, Oral Dis, vol.20, pp.120-127, 2014.

A. Saker, A. Benachi, J. P. Bonnefont, A. Munnich, Y. Dumez et al., , 2006.

, Genetic characterisation of circulating fetal cells allows non-invasive prenatal diagnosis of cystic fibrosis

, Prenat. Diagn, vol.26, pp.906-916

Y. Sato, Integrated molecular analysis of clear-cell renal cell carcinoma, Nat. Genet, vol.45, p.30, 2013.

P. Schraml, K. Struckmann, F. Hatz, S. Sonnet, C. Kully et al., VHL mutations and their correlation with tumour cell proliferation, microvessel density, and patient prognosis in clear cell renal cell carcinoma, J. Pathol, vol.196, pp.186-193, 2002.

R. L. Siegel, K. D. Miller, J. , and A. , Cancer statistics, vol.65, pp.5-29, 2015.

S. Sifakis, S. Ghatpande, A. Seppo, M. W. Kilpatrick, T. Tafas et al., Prenatal diagnosis of trisomy 21 through detection of trophoblasts in cervical smears, 2010.

. Dev, , vol.86, pp.311-313

E. Sinkala, Profiling protein expression in circulating tumour cells using microfluidic western blotting, Nat. Commun, vol.8, p.14622, 2017.

Y. Song, T. Tian, Y. Shi, W. Liu, Y. Zou et al., , 2017.

, Enrichment and single-cell analysis of circulating tumor cells, Chem. Sci, vol.8, pp.1736-1751

T. Sugino, T. Yamaguchi, G. Ogura, A. Saito, T. Hashimoto et al.,

T. Suzuki, , 2004.

V. Swaminathan, K. Mythreye, E. T. O'brien, A. Berchuck, G. C. Blobe et al., , 2011.

, Mechanical stiffness grades metastatic potential in patient tumor cells and in cancer cell lines, Cancer Res, vol.71, pp.5075-5080

A. Tabor, A. , and Z. , Update on procedure-related risks for prenatal diagnosis techniques, Fetal Diagn. Ther, vol.27, pp.1-7, 2010.

J. Thiele, K. Bethel, M. Králí?ková, and P. Kuhn, Circulating Tumor Cells: Fluid Surrogates of Solid Tumors, Annu. Rev. Pathol, vol.12, pp.419-447, 2017.

I. Tirosh, Dissecting the multicellular ecosystem of metastatic melanoma by single-cell RNAseq, Science, vol.352, pp.189-196, 2016.

C. Trapnell, Defining cell types and states with single-cell genomics, Genome Res, vol.25, pp.1491-1498, 2015.

S. Vega, A. V. Morales, O. H. Ocaña, F. Valdés, I. Fabregat et al., Snail blocks the cell cycle and confers resistance to cell death, Genes Dev, vol.18, pp.1131-1143, 2004.

M. H. Voss, Tumor genetic analyses of patients with metastatic renal cell carcinoma and extended benefit from mTOR inhibitor therapy, Clin. Cancer Res. Off. J. Am. Assoc. Cancer Res, vol.20, 1955.

X. Wang, M. Tanaka, S. Krstin, H. S. Peixoto, C. C. Moura et al., Cytoskeletal interference-A new mode of action for the anticancer drugs camptothecin and topotecan, p.31, 2016.

, Orme aux Merisiers RD 128 / 91190 Saint-Aubin, France Lucile BRONCY Pharmacol, vol.789, pp.265-274

W. Wenjun, W. Zhihua, W. Zhuo, D. Yuliang, and S. Qihui, Fast isolation and ex vivo culture of circulating tumor cells from the peripheral blood of lung cancer patients, Yi Chuan Hered, vol.39, pp.66-74, 2017.

W. Xu, R. Mezencev, B. Kim, L. Wang, J. Mcdonald et al., , 2012.

X. Xu, Single-cell exome sequencing reveals single-nucleotide mutation characteristics of a kidney tumor, Cell, vol.148, pp.886-895, 2012.

B. Yan, Single-cell genomic profiling of acute myeloid leukemia for clinical use: A pilot study, 2017.

, Oncol. Lett, vol.13, pp.1625-1630

B. Yu, X. Dong, S. Gravina, Ö. Kartal, T. Schimmel et al., , 2017.

. Genome-wide, Single-Cell DNA Methylomics Reveals Increased Non-CpG Methylation during Human Oocyte Maturation, Stem Cell Rep

M. Yu, Circulating breast tumor cells exhibit dynamic changes in epithelial and mesenchymal composition, Science, vol.339, pp.580-584, 2013.

M. Yu, Cancer therapy. Ex vivo culture of circulating breast tumor cells for individualized testing of drug susceptibility, Science, vol.345, pp.216-220, 2014.
URL : https://hal.archives-ouvertes.fr/hal-01948490

C. Zhao, S. Hu, X. Huo, and Y. Zhang, Dr.seq2: A quality control and analysis pipeline for parallel single cell transcriptome and epigenome data, PloS One, vol.12, 2017.
URL : https://hal.archives-ouvertes.fr/insu-01677929

C. Zhao, J. Tynan, M. Ehrich, G. Hannum, R. Mccullough et al., Detection of fetal subchromosomal abnormalities by sequencing circulating cell-free DNA from maternal plasma, Clin. Chem, vol.61, pp.608-616, 2015.

S. Zhu, T. Qing, Y. Zheng, L. Jin, and L. Shi, Advances in single-cell RNA sequencing and its applications in cancer research, Oncotarget, 2017.