, Impaired neuropathic pain responses in mice lacking the chemokine receptor CCR2, Proceedings of the National Academy of Sciences of the United States of America, vol.100, pp.7947-7952, 2003.
, Astrocyte-endothelial interactions at the blood-brain barrier, Nature Reviews Neuroscience, vol.7, issue.1, pp.41-53, 2006.
DOI : 10.1038/nrn1824
, Genetic demonstration of a role for PKA in the late phase of LTP and in hippocampus-based long-term memory, Cell, vol.88, issue.5, pp.615-626, 1997.
, Modified hippocampal long-term potentiation in PKC gammamutant mice, Cell, vol.75, issue.7, pp.1253-1262, 1993.
DOI : 10.1016/0092-8674(93)90613-u
, Insulin and insulin-like growth factor receptors in the nervous system, Molecular neurobiology, pp.71-100, 1989.
, Tyrosine phosphorylation of GluR2 is required for insulinstimulated AMPA receptor endocytosis and LTD, vol.23, pp.1040-1050, 2004.
DOI : 10.1038/sj.emboj.7600126
URL : http://emboj.embopress.org/content/23/5/1040.full.pdf
, Cognition and hippocampal synaptic plasticity in mice with a homozygous tau deletion, Neurobiology of Aging, vol.35, issue.11, pp.2474-2478, 2014.
DOI : 10.1016/j.neurobiolaging.2014.05.005
, Acute third ventricular administration of insulin decreases food intake in two paradigms, Pharmacology Biochemistry and Behavior, vol.72, pp.423-429, 2002.
DOI : 10.1016/s0091-3057(01)00780-8
, Granules in glial cells of patients with Alzheimer's disease are immunopositive for C-terminal sequences of beta-amyloid protein, Neuroscience letters, vol.206, issue.2-3, pp.169-172, 1996.
, Inflammation and Alzheimer's disease, 2000.
, Substrate specificities of tyrosine-specific protein kinases toward cytoskeletal proteins in vitro, The Journal of biological chemistry, vol.261, issue.31, pp.14797-14803, 1986.
, Electrical stimulation protocols for hippocampal synaptic plasticity and neuronal hyper-excitability: Are they effective or relevant?, Experimental Neurology, vol.204, issue.1, pp.1-13, 2007.
DOI : 10.1016/j.expneurol.2006.12.009
, Evidence for the involvement of TNF and NF-kappaB in hippocampal synaptic plasticity, Synapse, vol.35, issue.2, pp.151-159, 2000.
, Cooperative Phosphorylation of the Tumor Suppressor Phosphatase and Tensin Homologue (PTEN) by Casein Kinases and Glycogen Synthase Kinase 3?, Journal of Biological Chemistry, vol.280, issue.42, pp.35195-35202, 2005.
, Association of MAPT haplotypes with Alzheimer's disease risk and MAPT brain gene expression levels, vol.6, p.39, 2014.
DOI : 10.1186/alzrt268
URL : https://alzres.biomedcentral.com/track/pdf/10.1186/alzrt268
, Role of abnormally phosphorylated tau in the breakdown of microtubules in Alzheimer disease, Proceedings of the National Academy of Sciences of the United States of America, vol.91, pp.5562-5566, 1994.
, Dominant Role of the p110? Isoform of PI3K over p110? in Energy Homeostasis Regulation by POMC and AgRP Neurons, Cell Metabolism, vol.10, issue.5, pp.343-354, 2009.
, Uber eigenartige Krankheitsfalle des spateren Alters, vol.4, pp.356-385, 1911.
DOI : 10.1177/0957154x9100200506
, The Rat Nervous System, pp.443-493, 1995.
, The Hippocampus Book, p.2007, 2007.
, Structure and novel exons of the human tau gene, Biochemistry, issue.43, pp.10626-10633, 1992.
, Regulation of AMPA receptor trafficking and synaptic plasticity, Current Opinion in Neurobiology, vol.22, pp.461-469, 2012.
DOI : 10.1016/j.conb.2011.12.006
URL : http://europepmc.org/articles/pmc3392447?pdf=render
, Alcohol consumption as a risk factor for dementia and cognitive decline: meta-analysis of prospective studies. The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry, vol.17, pp.542-555, 2009.
, Induction and expression mechanisms of postsynaptic NMDA receptorindependent homosynaptic long-term depression, Progress in Neurobiology, vol.78, issue.1, pp.17-37, 2006.
DOI : 10.1016/j.pneurobio.2005.12.001
, Dynamic signaling between astrocytes and neurons. Annual review of physiology, vol.63, pp.795-813, 2001.
DOI : 10.1146/annurev.physiol.63.1.795
URL : https://digital.csic.es/bitstream/10261/60766/1/accesoRestringido.pdf
, Fractalkine Signaling and Microglia Functions in the Developing Brain, Cellular immunology, vol.80, issue.1, pp.43-56, 2015.
DOI : 10.1155/2015/689404
URL : http://doi.org/10.1155/2015/689404
, Diabetes and ageing induced vascular inflammation, The Journal of Physiology, 2015.
DOI : 10.1113/jp270841
URL : http://onlinelibrary.wiley.com/doi/10.1113/JP270841/pdf
, The control processes of short-term memory, pp.1-43, 1971.
, Pyrogens specifically disrupt the acquisition of a task involving cognitive processing in the rat, Brain, behavior, and immunity, vol.9, issue.2, pp.129-148, 1995.
, Endosomal proteolysis of insulin by an acidic thiol metalloprotease unrelated to insulin degrading enzyme, Journal of Biological Chemistry, vol.269, issue.4, pp.3010-3016, 1994.
, Insulin-degrading enzyme. Clinical and investigative medicine, Médecine clinique et experimentale, vol.19, issue.3, pp.149-60, 1996.
, Impaired interleukin-1 signaling is associated with deficits in hippocampal memory processes and neural plasticity, Hippocampus, vol.13, issue.7, pp.826-834, 2003.
, Cognitive psychology and human memory, Trends in Neurosciences, vol.11, issue.4, pp.176-181, 1988.
, The epissodic buffer: a new component of working memory?, Trends in Cognitive Sciences, vol.4, issue.1, pp.417-423, 2000.
, Working memory, Current biology : CB, vol.20, issue.4, pp.136-140, 2010.
, The genetics of Alzheimer's disease, Clinical Interventions in Aging, vol.9, pp.535-551, 2014.
, Structural Components of Synaptic Plasticity and Memory Consolidation, pp.1-30, 2015.
, Chemokines and their receptors in the central nervous system, Frontiers in neuroendocrinology, vol.22, issue.3, pp.147-184, 2002.
, A Specific Role for Group I mGluRs in Hippocampal LTP and Hippocampus-Dependent Spatial Learning, Learning & Memory, vol.6, issue.2, pp.138-152, 1999.
, Hippocampal interleukin-1 beta gene expression during long-term potentiation decays with age, Annals of the New York Academy of Sciences, vol.992, pp.1-8, 2003.
, Interleukin-6: a cytokine to forget. The FASEB journal : official publication of the Federation of, vol.18, pp.1788-1790, 2004.
, Accumulation of abnormally phosphorylated tau precedes the formation of neurofibrillary tangles in Alzheimer's disease, Brain research, vol.477, issue.1-2, pp.90-99, 1989.
, Chemokines and brain functions, Current drug targets. Inflammation and allergy, vol.4, issue.3, pp.387-399, 2005.
, The chemokine BRAK/CXCL14 regulates synaptic transmission in the adult mouse dentate gyrus stem cell niche, Journal of Neurochemistry, vol.119, issue.6, pp.1173-1182, 2011.
, Control of GluR1 AMPA receptor function by cAMP-dependent protein kinase, The Journal of neuroscience : the official journal of the Society for Neuroscience, vol.20, issue.1, pp.89-102, 2000.
, Transport of insulin across the blood-brain barrier: Saturability at euglycemic doses of insulin, European Journal of Pharmacology, vol.490, issue.1-3, pp.1423-1429, 1997.
, Selective, physiological transport of insulin across the blood-brain barrier. Novel demonstration by species-specific radioimmunoassays, Peptides, vol.18, issue.8, pp.1257-1262, 1997.
, Regional dissociations within the hippocampus-Memory and anxiety, Neuroscience and Biobehavioral Reviews, vol.28, issue.3, pp.273-283, 2004.
, Ventral hippocampal lesions affect anxiety but not spatial learning, Behavioural Brain Research, vol.139, issue.1-2, pp.197-213, 2003.
, Hippocampal NMDA receptors and anxiety: At the interface between cognition and emotion, European Journal of Pharmacology, vol.626, issue.1, pp.49-56, 2010.
, BDNF mRNA expression in rat hippocampus following contextual learning is blocked by intrahippocampal IL-1?? administration, Journal of Neuroimmunology, vol.155, issue.1-2, pp.119-126, 2004.
, Memory for context is impaired by a post context exposure injection of interleukin-1 beta into dorsal hippocampus, Behavioural Brain Research, vol.134, issue.1-2, pp.291-298, 2002.
, Induction of LTP in the hippocampus needs synaptic activation of glutamate metabotropic receptors, Nature, vol.363, issue.6427, pp.347-350, 1993.
, Quantitative autoradiographic evidence for insulin receptors in the choroid plexus of the rat brain, Diabetes, vol.35, issue.2, pp.246-249, 1986.
, Glycogen synthase kinase 3 alteration in Alzheimer disease is related to neurofibrillary tangle formation. Molecular and chemical neuropathology / sponsored by the International Society for Neurochemistry and the World Federation of Neurology and research groups on neurochemistry and cerebrospinal fluid, vol.29, pp.253-61, 1996.
, Saturable transport of insulin from plasma into the central nervous system of dogs in vivo: A mechanism for regulated insulin delivery to the brain, Journal of Clinical Investigation, vol.92, issue.4, pp.1824-1830, 1993.
, Control of synaptic strength by glial TNFalpha, Science, issue.5563, pp.2282-2285, 2002.
, Beneficial effects of exercise in a transgenic mouse model of Alzheimer's disease-like Tau pathology, Neurobiology of disease, vol.43, issue.2, pp.486-494, 2011.
, Reduced long-term potentiation in the dentate gyrus of transgenic mice with cerebral overexpression of interleukin-6, Neuroscience Letters, vol.198, issue.2, pp.95-98, 1995.
, Interleukin 1 beta inhibits synaptic strength and long-term potentiation in the rat CA1 hippocampus, Brain research, vol.628, issue.12, pp.227-234, 1993.
, mGluRs induce a long-term depression in the ventral tegmental area that involves a switch of the subunit composition of AMPA receptors, European Journal of Neuroscience, vol.21, issue.5, pp.1280-1288, 2005.
, Induction of inflammatory mediators and microglial activation in mice transgenic for mutant human P301S tau protein. The American journal of pathology, vol.165, pp.1643-1652, 2004.
, Presence of reactive microglia and neuroinflammatory mediators in a case of frontotemporal dementia with P301S mutation, vol.8, pp.221-229, 2011.
, Intranasal insulin as a therapeutic option in the treatment of cognitive impairments, Experimental Gerontology, vol.46, pp.112-115, 2011.
, Intranasal insulin improves memory in humans, Psychoneuroendocrinology, vol.29, issue.10, pp.1326-1334, 2004.
, Intranasal Insulin to Improve Memory Function in Humans, Neuroendocrinology, vol.86, issue.2, pp.136-142, 2007.
, Fractalkine/CX3CL1 depresses central synaptic transmission in mouse hippocampal slices, Neuropharmacology, vol.51, pp.816-821, 2006.
, Spatial processing in the brain: the activity of hippocampal place cells, Annual review of neuroscience, vol.24, pp.459-486, 2001.
, Obesity and central obesity as risk factors for incident dementia and its subtypes: A systematic review and meta-analysis, Obesity Reviews, vol.9, issue.3, pp.204-218, 2008.
, CXCR4 chemokine receptor signaling mediates pain hypersensitivity in association with antiretroviral toxic neuropathy, Brain, Behavior, and Immunity, vol.21, issue.5, pp.581-591, 2007.
, Regulation of Tau Pathology by the Microglial Fractalkine Receptor, Neuron, vol.68, issue.1, pp.19-31, 2010.
, Interleukin-6 affects scopolamine-induced amnesia, but not brain amino acid levels in mice, Neuroreport, vol.8, issue.7, pp.1775-1778, 1997.
, Place learning and hippocampal synaptic plasticity in streptozotocin-induced diabetic rats, Diabetes, vol.45, issue.9, pp.1259-1266, 1996.
, Water maze learning and hippocampal synaptic plasticity in streptozotocin-diabetic rats: effects of insulin treatment, Brain Research, vol.800, issue.1, pp.125-135, 1998.
, Cognition and diabetes: a lifespan perspective, The Lancet Neurology, vol.7, issue.2, pp.184-190, 2008.
, Ageing, hippocampal synaptic activity and magnesium, Magnesium research : official organ of the International Society for the Development of Research on Magnesium, vol.19, pp.199-215, 2006.
, Preventive actions of a synthetic antioxidant in a novel animal model of AIDS dementia, Brain Research, vol.795, issue.1-2, pp.349-357, 1998.
, Alzheimer's disease, Lancet, vol.368, issue.9533, pp.387-403, 2006.
URL : https://hal.archives-ouvertes.fr/hal-01098836
, A synaptic model of memory: long-term potentiation in the hippocampus, Nature, issue.6407, pp.31-39, 1993.
, Expression of NMDA receptor-dependent LTP in the hippocampus: bridging the divide, Molecular brain, vol.6, p.5, 2013.
, Long-lasting potentiation of synaptic transmission in the dentate area of the anaesthetized rabbit following stimulation of the preforant path, Journal of physiology, vol.232, issue.2, pp.331-356, 1973.
, Interleukin-1 beta and interleukin-6 are elevated in the cerebrospinal fluid of Alzheimer's and de novo Parkinson's disease patients, Neuroscience letters, pp.17-20, 1995.
, Involvement of chemokines in pain, European Journal of Pharmacology, vol.429, issue.1-3, pp.115-119, 2001.
, Synaptic Incorporation of AMPA Receptors during LTP Is Controlled by a PKC Phosphorylation Site on GluR1, Neuron, vol.51, issue.2, pp.213-225, 2006.
, Dual MAP kinase pathways mediate opposing forms of longterm plasticity at CA3-CA1 synapses, Nature neuroscience, vol.3, issue.11, pp.1107-1112, 2000.
, Hippocampal long-term depression: Arachidonic acid as a potential retrograde messenger, Neuropharmacology, vol.34, issue.11, pp.1581-1587, 1995.
, An anti-diabetes agent protects the mouse brain from defective insulin signaling caused by Alzheimer's disease-associated A? oligomers, Journal of Clinical Investigation, vol.122, issue.4, pp.1339-1353, 2012.
, Characterisation of LTP induced by the activation of glutamate metabotropic receptors in area CA1 of the hippocampus, Neuropharmacology, vol.32, issue.1, pp.1-9, 1993.
, A sequence of cytoskeleton changes related to the formation of neurofibrillary tangles and neuropil threads, Acta Neuropathologica, vol.87, issue.6, pp.554-567, 1994.
, Stages of the Pathologic Process in Alzheimer Disease, Journal of Neuropathology and Experimental Neurology, vol.70, issue.11, pp.960-969, 2011.
, Neuropathological stageing of Alzheimer-related changes, Acta neuropathologica, vol.82, issue.4, pp.239-259, 1991.
DOI : 10.1007/bf00308809
, Alzheimer's disease: Intraneuronal alterations precede insoluble amyloid-?? formation, Neurobiology of Aging, vol.25, issue.6, pp.713-718, 2004.
DOI : 10.1016/j.neurobiolaging.2003.12.015
, Cognitive function in young and adult IL (interleukin)-6 deficient mice, Behavioural Brain Research, vol.153, issue.2, pp.423-429, 2004.
DOI : 10.1016/j.bbr.2003.12.018
, Abnormal tau phosphorylation at Ser396 in Alzheimer's disease recapitulates development and contributes to reduced microtubule binding, Neuron, vol.10, issue.6, pp.1089-1099, 1993.
DOI : 10.1016/0896-6273(93)90057-x
, Local protein synthesis, actin dynamics, and LTP consolidation, Current Opinion in Neurobiology, vol.18, issue.5, pp.524-531, 2008.
DOI : 10.1016/j.conb.2008.09.013
, Interaction of tau with the neural plasma membrane mediated by tau's amino-terminal projection domain, Journal of Cell Biology, vol.131, issue.5, pp.1327-1340, 1995.
, Proinflammatory cytokines differentially affect leverpress avoidance acquisition in rats, Behavioural Brain Research, vol.153, issue.2, pp.351-355, 2004.
DOI : 10.1016/j.bbr.2003.12.025
, Reduction of food intake and body weight by chronic intraventricular insulin infusion, Brain research bulletin, vol.12, pp.571-575, 1984.
DOI : 10.1016/0361-9230(84)90174-6
, Neurofibrillary tangles of Alzheimer ' s disease : An immunohistochemical study Neurofibrillary tangles of Alzheimer ' s disease : an immunohistochemical studv, J. Submicrosc. Cytol, 1985.
, Neurotoxicity and Memory Deficits Induced by Soluble LowMolecular-Weight Amyloid-1-42 Oligomers Are Revealed In Vivo by Using a Novel Animal Model, Journal of Neuroscience, vol.32, issue.23, pp.7852-7861, 2012.
, Intraventricular insulin and leptin reduce food intake and body weight in C57BL/6J mice, Physiology and Behavior, vol.89, pp.687-691, 2006.
DOI : 10.1016/j.physbeh.2006.08.008
, Role of brain insulin receptor in control of body weight and reproduction, Science, pp.2122-2125, 2000.
, Adaptive immunity affects learning behavior in mice, Brain, Behavior, and Immunity, vol.22, issue.6, pp.861-869, 2008.
DOI : 10.1016/j.bbi.2007.12.008
, Apolipoprotein E and its receptors in Alzheimer's disease: pathways, pathogenesis and therapy, Nature Reviews Neuroscience, vol.10, issue.5, pp.333-344, 2009.
DOI : 10.1038/nrn2620
URL : http://europepmc.org/articles/pmc2908393?pdf=render
, Tau protein isoforms, phosphorylation and role in neurodegenerative disorders11These authors contributed equally to this work, Brain Research Reviews, vol.33, issue.1, pp.95-130, 2000.
, Preferential adsorption, internalization and resistance to degradation of the major isoform of the Alzheimer's amyloid peptide, A ??1-42, in differentiated PC12 cells, Brain Research, vol.746, issue.1-2, pp.275-284, 1997.
, IRS-2 pathways integrate female reproduction and energy homeostasis, Nature, vol.407, issue.6802, pp.377-82, 2000.
DOI : 10.1038/35030105
, NMDA receptor dysfunction contributes to impaired brain-derived neurotrophic factor-induced facilitation of hippocampal synaptic transmission in a Tau transgenic model, Aging Cell, vol.12, pp.11-23, 2012.
, Tau protein binds to microtubules through a flexible array of distributed weak sites, Journal of Cell Biology, vol.115, issue.3, pp.717-730, 1991.
, Regulation of human MAPT gene expression, Molecular Neurodegeneration, vol.10, issue.1, p.28, 2015.
, Neurons bearing neurofibrillatory tangles are responsible for selected synaptic deficits in Alzheimer's disease, Neurobiology of Aging, vol.16, issue.3, pp.311-314, 1995.
, Chemokines and chemokine receptors in the brain: Implication in neuroendocrine regulation, Journal of Molecular Endocrinology, vol.38, pp.355-363, 2007.
, Inflammation, microglia, and alzheimer's disease, Neurobiology of Disease, vol.37, issue.3, pp.503-509, 2010.
, Intake of Sucrose-sweetened Water Induces Insulin Resistance and Exacerbates Memory Deficits and Amyloidosis in a Transgenic Mouse Model of Alzheimer Disease, Journal of Biological Chemistry, vol.282, issue.50, pp.36275-36282, 2007.
, Insulin receptor internalization: molecular mechanisms and physiopathological implications, Diabetologia, vol.37, issue.2, pp.117-141, 1994.
, Role of AMPA receptor endocytosis in synaptic plasticity, Nat Rev Neurosci, vol.2, issue.5, pp.315-324, 2001.
, Chemokine receptors in the central nervous system: role in brain inflammation and neurodegenerative diseases. Brain research, Brain research reviews, vol.48, pp.16-42, 2005.
, Chemokine CXCL8 modulates GluR1 phosphorylation, Journal of Neuroimmunology, pp.75-81, 0198.
, Impaired synaptic plasticity and learning in aged amyloid precursor protein transgenic mice, Nature neuroscience, vol.2, issue.3, pp.271-276, 1999.
, Early-onset Alzheimer's disease caused by mutations at codon 717 of the beta-amyloid precursor protein gene, Nature, vol.353, issue.6347, pp.844-846, 1991.
, Intracerebroventricular streptozotocin exacerbates Alzheimer-like changes of 3xTg-AD mice, Molecular neurobiology, vol.49, issue.1, pp.547-62, 2014.
, Insulin Receptor Signaling Regulates Synapse Number, Dendritic Plasticity, and Circuit Function In Vivo, Neuron, vol.58, pp.708-719, 2008.
, Synaptic dysfunction in hippocampus of transgenic mouse models of Alzheimer's disease: A multi-electrode array study, Neurobiology of Disease, vol.44, issue.3, pp.284-291, 2011.
, Insulin causes a transient tyrosine phosphorylation of NR2A and NR2B NMDA receptor subunits in rat hippocampus, Journal of Neurochemistry, vol.72, issue.4, pp.1523-1528, 1999.
, Phosphorylation of the AMPA receptor subunit GluR2 differentially regulates its interaction with PDZ domain-containing proteins, The Journal of neuroscience : the official journal of the Society for Neuroscience, vol.20, issue.19, pp.7258-7267, 2000.
, Synaptic plasticity: multiple forms, functions, and mechanisms, Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, vol.33, issue.1, pp.18-41, 2008.
, Alzheimer-associated A b oligomers impact the central nervous system to induce peripheral metabolic deregulation, vol.7, pp.190-210, 2015.
, Purification of tau, a microtubuleassociated protein that induces assembly of microtubules from purified tubulin, Journal of molecular biology, vol.116, issue.2, pp.207-225, 1977.
, Preserved learning and retention of pattern-analyzing skill in amnesia: dissociation of knowing how and knowing that, Science, issue.4466, pp.207-210, 1980.
, Long-term depression in the CNS, Nature reviews. Neuroscience, vol.11, issue.7, pp.459-473, 2010.
, Receptor trafficking and synaptic plasticity, Nature reviews. Neuroscience, vol.5, issue.12, pp.952-962, 2004.
DOI : 10.1038/nrn1556
, The P38 mitogen-activated protein kinase inhibitor SB203580 antagonizes the inhibitory effects of interleukin-1beta on long-term potentiation in the rat dentate gyrus in vitro, Neuroscience, vol.93, issue.1, pp.57-69, 1999.
, Reduced hippocampal insulin-degrading enzyme in late-onset Alzheimer's disease is associated with the apolipoprotein E-epsilon4 allele, The American journal of pathology, vol.162, issue.1, pp.313-319, 2003.
, Cerebrospinal fluid and plasma insulin levels in Alzheimer's disease: relationship to severity of dementia and apolipoprotein E genotype, Neurology, vol.50, issue.1, pp.164-168, 1998.
, Intranasal insulin therapy for Alzheimer disease and amnestic mild cognitive impairment: a pilot clinical trial, Archives of neurology, vol.69, issue.1, pp.29-38, 2012.
, The intersection of amyloid beta and tau in glutamatergic synaptic dysfunction and collapse in Alzheimer's disease, Ageing Research Reviews, vol.12, issue.3, pp.757-763, 2013.
, APOE genotype-dependent modulation of astrocyte chemokine CCL3 production, Glia, vol.63, issue.1, pp.51-65, 2015.
, The MAPK/ERK cascade targets both Elk-1 and cAMP response element-binding protein to control long-term potentiation-dependent gene expression in the dentate gyrus in vivo, The Journal of neuroscience : the official journal of the Society for Neuroscience, vol.20, issue.12, pp.4563-4572, 2000.
URL : https://hal.archives-ouvertes.fr/hal-00168752
, Amyloid-beta peptide oligomers disrupt axonal transport through an NMDA receptor-dependent mechanism that is mediated by glycogen synthase kinase 3beta in primary cultured hippocampal neurons, The Journal of neuroscience : the official journal of the Society for Neuroscience, vol.30, issue.27, pp.9166-9171, 2010.
, Nonoverlapping but synergetic tau and APP pathologies in sporadic Alzheimer's disease, Neurology, vol.59, issue.3, pp.398-407, 2002.
, The biochemical pathway of neurofibrillary degeneration in aging and Alzheimer's disease, Neurology, vol.52, issue.6, pp.1158-1165, 1999.
, Dysregulation of Insulin Signaling, Glucose Transporters, OGlcNAcylation, and Phosphorylation of Tau and Neurofilaments in the Brain, The American Journal of Pathology, vol.175, issue.5, pp.2089-2098, 2009.
, Regulatory mechanisms of AMPA receptors in synaptic plasticity, Nature reviews. Neuroscience, vol.8, issue.2, pp.101-113, 2007.
, Ca2+/calmodulin-kinase II enhances channel conductance of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate type glutamate receptors, Proceedings of the National Academy of Sciences of the United States of America, vol.96, pp.3269-3274, 1999.
, Depressed mood and the incidence of Alzheimer's disease in the elderly living in the community, Archives of general psychiatry, vol.53, issue.2, pp.175-182, 1996.
, Differential Regulation of Dynein and Kinesin Motor Proteins by Tau, Science, issue.5866, pp.1086-1089, 2008.
, Aging of the brain, entropy, and Alzheimer disease, Neurology, vol.67, issue.8, pp.1340-1352, 2006.
, Modulation of the dynamic instability of tubulin assembly by the microtubule-associated protein tau, Molecular biology of the cell, vol.3, issue.10, pp.1141-1154, 1992.
, Decreased fractalkine and increased IP-10 expression in aged brain of APPswe transgenic mice, Neurochemical Research, vol.33, issue.6, pp.1085-1089, 2008.
, Insulin in central nervous system: More than just a peripheral hormone, Journal of Aging Research, 2012.
DOI : 10.1155/2012/384017
URL : http://downloads.hindawi.com/journals/jar/2012/384017.pdf
, Blood-brain barrier transcytosis of insulin in developing rabbits, Brain research, vol.420, issue.1, pp.32-38, 1987.
, Behavioral deficit, oxidative stress, and mitochondrial dysfunction precede tau pathology in P301S transgenic mice, The FASEB Journal, vol.25, issue.11, pp.4063-4072, 2011.
DOI : 10.1096/fj.11-186650
URL : https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3205832/pdf
, Modeling the relation between neurofibrillary tangles and intellectual status, Neurobiology of Aging, vol.18, issue.3, pp.267-273, 1997.
DOI : 10.1016/s0197-4580(97)80306-5
, The ?-propensity of tau determines aggregation and synaptic loss in inducible mouse models of tauopathy, Journal of Biological Chemistry, vol.282, issue.43, pp.31755-31765, 2007.
, Dendritic spine changes associated with hippocampal long-term synaptic plasticity, Nature, vol.399, issue.6731, pp.66-70, 1999.
DOI : 10.1038/19978
, RAGE-dependent signaling in microglia contributes to neuroinflammation, Abeta accumulation, and impaired learning/memory in a mouse model of Alzheimer's disease. The FASEB journal : official publication of the Federation of, American Societies for Experimental Biology, vol.6, issue.2, pp.1043-1055, 2003.
, Insulin-degrading enzyme regulates the levels of insulin, amyloid betaprotein, and the beta-amyloid precursor protein intracellular domain in vivo, Proceedings of the National Academy of Sciences of the United States of America, vol.100, pp.4162-4169, 2003.
, Protection of synapses against Alzheimer's-linked toxins: insulin signaling prevents the pathogenic binding of Abeta oligomers, Proceedings of the National Academy of Sciences of the United States of America, vol.106, pp.1971-1977, 2009.
, Inflammation, Defective Insulin Signaling, and Mitochondrial Dysfunction as Common Molecular Denominators Connecting Type 2 Diabetes to Alzheimer Disease, Diabetes, vol.63, issue.7, pp.2262-2272, 2014.
, The many faces of insulin-like peptide signalling in the brain, Nature Reviews Neuroscience, vol.13, issue.4, pp.225-239, 2012.
, Metabotropic glutamate 1 receptor: current concepts and perspectives, Pharmacological reviews, vol.60, issue.4, pp.536-581, 2008.
DOI : 10.1124/pr.108.000166
URL : http://pharmrev.aspetjournals.org/content/pharmrev/60/4/536.full.pdf
, Inflammation, defective insulin signaling, and neuronal dysfunction in Alzheimer's disease, Alzheimer's & Dementia, vol.10, issue.1, pp.76-83, 2014.
DOI : 10.1016/j.jalz.2013.12.010
URL : https://doi.org/10.1016/j.jalz.2013.12.010
, Glial Biology in Learning and Cognition. The Neuroscientist : a review journal bringing neurobiology, p.1073858413504465, 2013.
DOI : 10.1177/1073858413504465
URL : http://journals.sagepub.com/doi/pdf/10.1177/1073858413504465
, Short-term forms of presynaptic plasticity, Current Opinion in Neurobiology, vol.21, issue.2, pp.269-274, 2011.
DOI : 10.1016/j.conb.2011.02.003
URL : http://europepmc.org/articles/pmc3599780?pdf=render
, Neurobehavioral alterations in developing transgenic mice expressing TNF-alpha in the brain, Brain, behavior, and immunity, vol.10, issue.2, pp.126-138, 1996.
, T cells specifically targeted to amyloid plaques enhance plaque clearance in a mouse model of alzheimer's disease, PLoS ONE, issue.5, p.5, 2010.
, From epidemiology to pathophysiology: what about caffeine in Alzheimer's disease?, Biochemical Society transactions, vol.42, issue.2, pp.587-92, 2014.
DOI : 10.1042/bst20130229
URL : http://europepmc.org/articles/pmc4440674?pdf=render
, AMPA receptors and synaptic plasticity: a chemist's perspective, Nature chemical biology, vol.6, issue.2, pp.89-97, 2010.
DOI : 10.1038/nchembio.298
, Effect of Proinflammatory Gene Polymorphisms on the Risk of Alzheimer's Disease. Neuro-degenerative diseases, pp.1-7, 2013.
, Intraventricular insulin reduces food intake and body weight of marmots during the summer feeding period, Physiology & behavior, vol.49, issue.2, pp.335-343, 1991.
, Seasonal changes in CSF insulin levels in marmots: insulin may not be a satiety signal for fasting in winter, The American journal of physiology, vol.260, issue.4, pp.712-718, 1991.
, Food intake and serum insulin responses to intraventricular infusions of insulin and IGF-I, Physiology & behavior, vol.50, pp.745-749, 1991.
, Critical role for the p110alpha phosphoinositide-3-OH kinase in growth and metabolic regulation, Nature, issue.7091, pp.366-370, 2006.
, Ultrastructure of the microglia that phagocytose amyloid and the microglia that produce beta-amyloid fibrils, Acta neuropathologica, vol.84, issue.3, pp.225-233, 1992.
, Enhanced insulin binding to blood-brain barrier in vivo and to brain microvessels in vitro in newborn rabbits, Diabetes, vol.34, issue.8, pp.728-733, 1985.
, The mouse brain in stereotaxic coordinates, 2007.
, Microglial response to amyloid plaques in APPsw transgenic mice. The American journal of pathology, vol.152, pp.307-317, 1998.
, Peripheral hyperinsulinemia promotes tau phosphorylation in vivo, Diabetes, vol.54, issue.12, pp.3343-3351, 2005.
, Insulin interactions with liver plasma membranes, The Journal of Biological Chemistry, vol.247, issue.12, pp.3953-3961, 1972.
, Brain insulin and insulin receptors in aging and sporadic Alzheimer's disease, Journal of Neural Transmission, vol.105, issue.4, p.423, 1998.
, Excitotoxic Brain Injury Stimulates Expression of the Chemokine Receptor CCR5 in Neonatal Rats, The American Journal of Pathology, vol.153, issue.5, pp.1631-1640, 1998.
, Extracellular signal-regulated protein kinase activation is required for metabotropic glutamate receptor-dependent long-term depression in hippocampal area CA1, The Journal of neuroscience, vol.24, issue.20, pp.4859-4864, 2004.
, Control of GnRH neuronal activity by metabolic factors: The role of leptin and insulin, Molecular and Cellular Endocrinology, pp.133-139, 2006.
, PTEN: A master regulator of neuronal structure, function, and plasticity, Communicative and Integrative Biology, vol.7, pp.28-31, 2014.
, Anti-inflammatory impact of minocycline in a mouse model of tauopathy, Frontiers in Psychiatry, vol.1, pp.1-8, 2010.
, Hippocampal long-term depression is required for the consolidation of spatial memory, Proceedings of the National Academy of Sciences of the United States of America, vol.107, pp.16697-702, 2010.
, PTEN Tumor Suppressor Network in PI3K-Akt Pathway Control, Genes Cancer, vol.1, issue.12, pp.1170-1177, 2010.
, CCL3 correlates with the number of mood disturbances and personality changes in patients with Alzheimer's disease, Psychiatry Research, vol.176, pp.261-264, 2010.
, Increased mortality and spatial memory deficits in TNF-?-deficient mice in ceftriaxone-treated experimental pneumococcal meningitis, Neurobiology of Disease, vol.16, issue.1, pp.133-138, 2004.
, Sustained interleukin-1? overexpression exacerbates tau pathology despite reduced amyloid burden in an Alzheimer's mouse model, The Journal of neuroscience : the official journal of the Society for Neuroscience, vol.33, issue.11, pp.5053-64, 2013.
DOI : 10.1523/jneurosci.4361-12.2013
URL : http://www.jneurosci.org/content/33/11/5053.full.pdf
, Metabotropic Glutamate ReceptorMediated Long-Term Depression : Molecular Mechanisms, Pharmacological reviews, vol.61, issue.4, pp.395-412, 2009.
DOI : 10.1124/pr.109.001735
URL : http://europepmc.org/articles/pmc2802426?pdf=render
, Mechanisms Underlying Inflammation in Neurodegeneration, Cell, vol.140, issue.6, pp.918-934, 2010.
DOI : 10.1016/j.cell.2010.02.016
URL : https://doi.org/10.1016/j.cell.2010.02.016
, Alzheimer's disease: Initial report of the purification and characterization of a novel cerebrovascular amyloid protein, Biochemical and Biophysical Research Communications, vol.120, issue.3, pp.885-890, 1984.
, Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease, Nature, vol.349, issue.6311, pp.704-706, 1991.
, Expression of separate isoforms of human tau protein: correlation with the tau pattern in brain and effects on tubulin polymerization, The EMBO journal, vol.9, issue.13, pp.4225-4230, 1990.
, On the fine structure of the pes Hippocampi major (with plates XIII-XXIII), Brain Research Bulletin, vol.54, issue.5, pp.461-483, 2001.
, Memory impairment induced by IL-1? is reversed by ?-MSH through central melanocortin-4 receptors, Brain, Behavior, and Immunity, vol.23, issue.6, pp.817-822, 2009.
DOI : 10.1016/j.bbi.2009.03.001
, Expression of protein kinase C inhibitor blocks cerebellar long-term depression without affecting Purkinje cell excitability in alert mice, The Journal of neuroscience : the official journal of the Society for Neuroscience, vol.21, issue.15, pp.5813-5823, 2001.
URL : https://hal.archives-ouvertes.fr/inserm-02120677
, A dual role for interleukin-1 in hippocampal-dependent memory processes, Psychoneuroendocrinology, pp.1106-1115, 2007.
, Environmental enrichment restores memory functioning in mice with impaired IL-1 signaling via reinstatement of long-term potentiation and spine size enlargement, The Journal of neuroscience : the official journal of the Society for Neuroscience, vol.29, issue.11, pp.3395-3403, 2009.
, Reanalysis of the first case of Alzheimer's disease, Eur Arch Psychiatry Clin Neurosci, pp.10-13, 1999.
, Activation of Akt/PKB, increased phosphorylation of Akt substrates and loss and altered distribution of Akt and PTEN are features of Alzheimer's disease pathology, Journal of Neurochemistry, vol.93, issue.1, pp.105-117, 2005.
, Lentivirus-mediated downregulation of hypothalamic insulin receptor expression, Physiology & behavior, vol.92, issue.4, pp.691-701, 2007.
DOI : 10.1016/j.physbeh.2007.05.043
URL : http://europepmc.org/articles/pmc2129218?pdf=render
, Hippocampal Insulin Resistance Impairs Spatial Learning and Synaptic Plasticity, Diabetes, pp.1-35, 2015.
DOI : 10.2337/db15-0596
URL : http://diabetes.diabetesjournals.org/content/64/11/3927.full.pdf
, Tau is widely expressed in rat tissues, Journal of neurochemistry, vol.67, issue.3, pp.1235-1244, 1996.
DOI : 10.1046/j.1471-4159.1996.67031235.x
, Long term exposure to the chemokine CCL2 activates the nigrostriatal dopamine system: a novel mechanism for the control of dopamine release, Neuroscience, vol.162, issue.4, pp.1072-1080, 2009.
URL : https://hal.archives-ouvertes.fr/hal-00419267
, Status epilepticus evokes prolonged increase in the expression of CCL3 and CCL4 mRNA and protein in the rat brain, Acta Neurobiologiae Experimentalis, vol.71, pp.193-207, 2011.
, CCR1 Is an Early and Specific Marker of Alzheimer ' s Disease, Annals of Neurology, pp.638-646, 2003.
DOI : 10.1002/ana.10733
, Obese men respond to cognitive but not to catabolic brain insulin signaling, International Journal of Obesity, vol.32, issue.2, pp.275-282, 2008.
DOI : 10.1038/sj.ijo.0803722
URL : https://www.nature.com/articles/0803722.pdf
, Do astrocytes really exocytose neurotransmitters?, Nature reviews. Neuroscience, vol.11, issue.4, pp.227-265, 2010.
DOI : 10.1038/nrn2803
, Extrasynaptic NMDARs oppose synaptic NMDARs by triggering CREB shut-off and cell death pathways, Nature neuroscience, vol.5, issue.5, pp.405-414, 2002.
DOI : 10.1038/nn835
, Disappearance of actin-binding protein, drebrin, from hippocampal synapses in Alzheimer's disease, Journal of neuroscience research, vol.43, issue.1, pp.87-92, 1996.
DOI : 10.1002/jnr.490430111
, Structural changes at dendritic spine synapses during long-term potentiation, Philosophical transactions of the Royal Society of London. Series B, Biological sciences, vol.358, pp.745-748, 1432.
DOI : 10.1098/rstb.2002.1254
URL : http://europepmc.org/articles/pmc1693146?pdf=render
, Insulin receptors are widely distributed in the central nervous system of the rat, Nature, issue.5656, pp.827-829, 1978.
, The Organization of Behaviour. Organization, p.62, 1949.
, Insulin modulates hippocampal activity-dependent synaptic plasticity in a N-methyl-d-aspartate receptor and phosphatidyl-inositol-3-kinasedependent manner, Journal of Neurochemistry, vol.94, issue.4, pp.1158-1166, 2005.
, Sustained hippocampal IL-1? overexpression impairs contextual and spatial memory in transgenic mice, Brain, Behavior, and Immunity, vol.24, issue.2, pp.243-253, 2010.
DOI : 10.1016/j.bbi.2009.10.002
URL : http://europepmc.org/articles/pmc2818290?pdf=render
, Neuroinflammation in Alzheimer's disease, The Lancet Neurology, vol.14, issue.4, pp.388-405, 2015.
, A model for memory systems based on processing modes rather than consciousness, Nature reviews. Neuroscience, vol.11, issue.7, pp.523-532, 2010.
DOI : 10.1038/nrn2850
, Long-term potentiation depends on release of D-serine from astrocytes, Nature, vol.463, issue.7278, pp.232-236, 2010.
DOI : 10.1038/nature08673
URL : https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2807667
, Insulin-mediated cortical activity in the slow frequency range is diminished in obese mice and promotes physical inactivity, Diabetologia, vol.52, pp.2416-2424, 2009.
, Mechanism of cerebral beta-amyloid angiopathy: murine and cellular models, Brain pathology, vol.16, issue.1, pp.40-54, 2006.
DOI : 10.1111/j.1750-3639.2006.tb00560.x
, Progressive decline in avoidance learning paralleled by inflammatory neurodegeneration in transgenic mice expressing interleukin 6 in the brain, Proceedings of the National Academy of Sciences of the United States of America, vol.94, issue.4, pp.1500-1505, 1997.
, Phosphatidyl Inositol 3-Kinase Signaling in Hypothalamic Proopiomelanocortin Neurons Contributes to the Regulation of Glucose Homeostasis, Endocrinology, vol.150, issue.11, pp.4874-4882, 2009.
, Tau proteins: the molecular structure and mode of binding on microtubules, Journal of Cell Biology, vol.107, issue.4, pp.1449-1459, 1988.
, A central role for JNK in obesity and insulin resistance, Nature, vol.420, issue.6913, pp.333-336, 2002.
DOI : 10.1038/nature01137
, Diet-induced insulin resistance promotes amyloidosis in a transgenic mouse model of Alzheimer's disease, Faseb J, vol.18, issue.7, pp.902-904, 2004.
, Tau loss attenuates neuronal network hyperexcitability in mouse and Drosophila genetic models of epilepsy, Journal of Neuroscience, vol.33, issue.4, pp.1651-1659, 2013.
, Tau Mislocalization to Dendritic Spines Mediates Synaptic Dysfunction Independently of Neurodegeneration, Neuron, vol.68, issue.6, pp.1067-1081, 2010.
DOI : 10.1016/j.neuron.2010.11.030
URL : https://doi.org/10.1016/j.neuron.2010.11.030
, Increased adipose tissue expression of tumor necrosis factoralpha in human obesity and insulin resistance, Journal of Clinical Investigation, vol.95, issue.5, pp.2409-2415, 1995.
, IRS-1-Mediated Inhibition of Insulin Receptor Tyrosine Kinase Activity in TNF-a-and Obesity-Induced Insulin Resistance, Science, vol.271, issue.2, p.665, 1996.
, Activation of the phosphoinositide 3-kinase-Akt-mammalian target of rapamycin signaling pathway is required for metabotropic glutamate receptordependent long-term depression, The Journal of neuroscience, vol.24, issue.28, pp.6352-6361, 2004.
, The aging brain. Changes in the neuronal insulin/insulin receptor signal transduction cascade trigger late-onset sporadic Alzheimer disease (SAD). A minireview, Journal of neural transmission, vol.109, issue.7-8, pp.991-1002, 1996.
, Tau could protect DNA double helix structure, Biochimica et Biophysica Acta-Proteins and Proteomics, vol.1645, issue.2, pp.205-211, 2003.
DOI : 10.1016/s1570-9639(02)00538-1
URL : http://library.ibp.ac.cn/html/slwj/000180957900011.pdf
, Insulin induces a novel form of postsynaptic mossy fiber long-term depression in the hippocampus, Molecular and Cellular Neuroscience, vol.24, pp.831-841, 2003.
, Sustained activation of metabotropic glutamate receptor 5 and protein tyrosine phosphatases mediate the expression of (S)-3,5dihydroxyphenylglycine-induced long-term depression in the hippocampal CA1 region, Journal of neurochemistry, vol.96, issue.1, pp.179-194, 2006.
, An investigation into signal transduction mechanisms involved in insulin-induced long-term depression in the CA1 region of the hippocampus, Journal of neurochemistry, vol.89, pp.217-231, 2004.
, A genetic test of the effects of mutations in PKA on mossy fiber LTP and its relation to spatial and contextual learning, Cell, vol.83, issue.7, pp.1211-1222, 1995.
, Role for rapid dendritic protein synthesis in hippocampal mGluR-dependent long-term depression, Science, vol.288, issue.5469, pp.1254-1257, 2000.
DOI : 10.1126/science.288.5469.1254
, Chemical induction of mGluR5-and protein synthesis-dependent long-term depression in hippocampal area CA1, Journal of neurophysiology, vol.86, issue.1, pp.321-325, 2001.
DOI : 10.1152/jn.2001.86.1.321
, AMPARs and synaptic plasticity: The last 25 years, Neuron, vol.80, issue.3, pp.704-717, 2013.
DOI : 10.1016/j.neuron.2013.10.025
URL : https://doi.org/10.1016/j.neuron.2013.10.025
, P301L tau expression affects glutamate release and clearance in the hippocampal trisynaptic pathway, Journal of Neurochemistry, vol.132, issue.2, pp.169-182, 2015.
DOI : 10.1111/jnc.12967
URL : http://onlinelibrary.wiley.com/doi/10.1111/jnc.12967/pdf
, Interleukin-1beta abrogates long-term depression of hippocampal CA1 synaptic transmission, Synapse, issue.1, pp.54-57, 2003.
DOI : 10.1002/syn.10154
URL : http://neuronet.jp/pdf/O_048.pdf
, Glycogen synthase kinase 3 beta is identical to tau protein kinase I generating several epitopes of paired helical filaments, FEBS letters, vol.325, issue.3, pp.167-172, 1993.
DOI : 10.1016/0014-5793(93)81066-9
URL : http://onlinelibrary.wiley.com/doi/10.1016/0014-5793(93)81066-9/pdf
, Co-localization of glycogen synthase kinase-3 with neurofibrillary tangles and granulovacuolar degeneration in transgenic mice, The American journal of pathology, vol.163, issue.3, pp.1057-67, 2003.
, Presence of T-cytotoxic suppressor and leucocyte common antigen positive cells in Alzheimer's disease brain tissue, Neuroscience letters, vol.91, issue.3, pp.259-64, 1988.
, Long-term depression, Annual review of neuroscience, vol.12, pp.85-102, 1989.
, Dendritic function of tau mediates amyloid-? toxicity in alzheimer's disease mouse models, Cell, vol.142, pp.387-397, 2010.
, Drebrin A regulates dendritic spine plasticity and synaptic function in mature cultured hippocampal neurons, Journal of Cell Science, vol.122, issue.4, pp.524-534, 2009.
DOI : 10.1242/jcs.033464
URL : https://hal.archives-ouvertes.fr/hal-00417422
, Cytokine responses to LTP induction in the rat hippocampus: a comparison of in vitro and in vivo techniques, Learning & memory, vol.7, issue.6, pp.400-412, 2000.
, The C-terminus of the beta protein is critical in amyloidogenesis, Annals of the New York Academy of Sciences, vol.695, issue.617, pp.144-148, 1993.
, Cognitive defects are reversible in inducible mice expressing pro-aggregant full-length human Tau, Acta Neuropathologica, vol.123, issue.6, pp.787-805, 2012.
, Hippocampal tauopathy in tau transgenic mice coincides with impaired hippocampus-dependent learning and memory, and attenuated late-phase longterm depression of synaptic transmission, Neurobiology of Learning and Memory, vol.95, issue.3, pp.296-304, 2011.
, Observations in THY-Tau22 mice that resemble behavioral and psychological signs and symptoms of dementia, Behavioural Brain Research, vol.242, issue.1, pp.34-39, 2013.
, Toll-like receptor 4-dependent upregulation of cytokines in a transgenic mouse model of Alzheimer's disease, Journal of neuroinflammation, vol.5, p.23, 2008.
, Increased expression of the chemokines CXCL1 and MIP-1? by resident brain cells precedes neutrophil infiltration in the brain following prolonged soman-induced status epilepticus in rats, Journal of neuroinflammation, vol.8, issue.1, p.41, 2011.
, PTEN is recruited to the postsynaptic terminal for NMDA receptordependent long-term depression, The EMBO journal, vol.29, issue.16, pp.2827-2840, 2010.
DOI : 10.1038/emboj.2010.160
URL : http://emboj.embopress.org/content/29/16/2827.full.pdf
, Obesity induced by a high-fat diet is associated with reduced brain insulin transport in dogs, Diabetes, vol.49, issue.9, pp.1525-1533, 2000.
DOI : 10.2337/diabetes.49.9.1525
URL : http://diabetes.diabetesjournals.org/content/49/9/1525.full.pdf
, The CC chemokine receptor 5 regulates olfactory and social recognition in mice, Neuroscience research, vol.197, issue.6, pp.498-520, 1986.
DOI : 10.1016/j.neuroscience.2011.09.039
URL : http://europepmc.org/articles/pmc3210349?pdf=render
, The molecular biology of memory storage: a dialogue between genes and synapses, Science, vol.294, issue.5544, pp.1030-1038, 2001.
, Tumor necrosis factor ?-induced phosphorylation of insulin receptor substrate-1 (IRS-1), The Journal of Biological Chemistry, vol.270, issue.40, pp.23780-23784, 1995.
DOI : 10.1074/jbc.270.40.23780
URL : http://www.jbc.org/content/270/40/23780.full.pdf
, Involvement of multiple phosphatidylinositol 3-kinase-dependent pathways in the persistence of late-phase long term potentiation expression, Neuroscience, vol.137, pp.833-841, 2006.
, Insulin stimulates tyrosine phosphorylation of the insulin receptor in a cell-free system, Nature, vol.298, issue.5875, pp.667-669, 1982.
, PTEN, a negative regulator of PI3 kinase signalling, alters tau phosphorylation in cells by mechanisms independent of GSK-3, FEBS Letters, vol.580, pp.3121-3128, 2006.
, Insulin dysfunction and Tau pathology, Frontiers in Cellular Neuroscience, vol.8, pp.1-18, 2014.
, Increased Tau Phosphorylation and Cleavage in Mouse Models of Type 1 and Type 2 Diabetes, Endocrinology, vol.150, issue.12, pp.5294-5301, 2009.
, Interaction of the AMPA receptor subunit GluR2/3 with PDZ domains regulates hippocampal long-term depression, Proceedings of the National Academy of Sciences of the United States of America, vol.98, pp.11725-11730, 2001.
, Insulin regulation of GnRH gene expression through MAP kinase signaling pathways, Molecular and Cellular Endocrinology, vol.242, issue.1-2, pp.42-49, 2005.
DOI : 10.1016/j.mce.2005.07.002
, Blocking IL-1 signaling rescues cognition, attenuates tau pathology, and restores neuronal ?-catenin pathway function in an Alzheimer's disease model, Journal of immunology, vol.187, issue.12, pp.6539-6588, 2011.
DOI : 10.4049/jimmunol.1100620
URL : http://www.jimmunol.org/content/jimmunol/187/12/6539.full.pdf
, Lipopolysaccharide-induced inflammation exacerbates tau pathology by a cyclin-dependent kinase 5-mediated pathway in a transgenic model of Alzheimer's disease, The Journal of neuroscience : the official journal of the Society for Neuroscience, vol.25, issue.39, pp.8843-8853, 2005.
, Midlife vascular risk factors and Alzheimer's Disease in later life: Longitudinal, population based study, Bmj, vol.322, pp.1447-1451, 2001.
, CCL2 accelerates microglia-mediated A? oligomer formation and progression of neurocognitive dysfunction, PLoS ONE, issue.7, p.4, 2009.
, Finite scale of spatial representation in the hippocampus, Science, issue.5885, pp.140-143, 2008.
, Reduced fear expression after lesions of the ventral hippocampus, Proceedings of the National Academy of Sciences of the United States of America, vol.99, pp.10825-10830, 2002.
, Persistent protein kinase activation in the maintenance phase of long-term potentiation, Journal of Biological Chemistry, vol.266, issue.36, pp.24253-24256, 1991.
, Cellular trafficking and processing of the insulin receptor, FASEB journal : official publication of the Federation of American Societies for Experimental Biology, vol.5, issue.8, pp.2130-2138, 1991.
, Microglial phagocytosis induced by fibrillar beta-amyloid and IgGs are differentially regulated by proinflammatory cytokines, The Journal of neuroscience : the official journal of the Society for Neuroscience, vol.25, issue.36, pp.8240-8249, 2005.
, Apolipoprotein E promotes astrocyte colocalization and degradation of deposited amyloid-beta peptides, Nature medicine, vol.10, issue.7, pp.719-726, 2004.
, Tonic activation of CXC chemokine receptor 4 in immature granule cells supports neurogenesis in the adult dentate gyrus, The Journal of neuroscience : the official journal of the Society for Neuroscience, vol.28, issue.17, pp.4488-4500, 2008.
, Insulin Action in AgRP-Expressing Neurons Is Required for Suppression of Hepatic Glucose Production, Cell Metabolism, vol.5, issue.6, pp.438-449, 2007.
, Soluble forms of tau are toxic in Alzheimer's disease, Translational Neuroscience, vol.3, issue.3, pp.223-233, 2012.
, Synaptic alterations in the rTg4510 mouse model of tauopathy, Journal of Comparative Neurology, vol.521, issue.6, pp.1334-1353, 2013.
, Abnormal phosphorylation of a non-paired helical filament pool in Alzheimer disease, Journal of Biological Chemistry, vol.268, issue.32, pp.24374-24384, 1993.
, Inflammatory and hormonal measures predict neuropsychological functioning in systemic lupus erythematosus and rheumatoid arthritis patients, Journal of the International Neuropsychological Society, vol.7, issue.6, pp.745-754, 2001.
, Phosphorylation of the Actin Binding Protein Drebrin at S647 Is Regulated by Neuronal Activity and PTEN, PLoS ONE, vol.8, issue.8, pp.1-12, 2013.
, Phosphate analysis and dephosphorylation of modified tau associated with paired helical filaments, Brain research, vol.597, issue.2, pp.209-219, 1992.
, Alzheimer's beta-amyloid peptide specifically interacts with and is degraded by insulin degrading enzyme, FEBS letters, vol.345, pp.33-37, 1994.
, Impaired interleukin-1? and c-Fos expression in the hippocampus is associated with a spatial memory deficit in P2X7 receptor-deficient mice, PLoS ONE, issue.6, p.4, 2009.
, Intracellular amyloid-beta in Alzheimer's disease, Nature reviews. Neuroscience, vol.8, issue.7, pp.499-509, 2007.
, Targeting Receptor-Mediated Transport for Delivery of Biologics Across the Blood-Brain Barrier, Annual Review of Pharmacology and Toxicology, vol.55, issue.1, pp.613-631, 2015.
, Activation of metabotropic glutamate receptor 1 accelerates NMDA receptor trafficking, The Journal of neuroscience : the official journal of the Society for Neuroscience, vol.21, issue.16, pp.6058-6068, 2001.
, Toll-like receptors in Alzheimer's disease, Current Topics in Microbiology and Immunology, vol.336, issue.1, pp.137-153, 2009.
, Alterations in synaptic transmission and long-term potentiation in hippocampal slices from young and aged PDAPP mice, Brain Research, vol.840, issue.1-2, pp.23-35, 1999.
, Mechanisms regulating neuronal excitability and seizure development following mTOR pathway hyperactivation, Frontiers in Molecular Neuroscience, vol.7, pp.1-15, 2014.
, A2A adenosine receptor deletion is protective in a mouse model of Tauopathy, Molecular Psychiatry, pp.1-11, 2014.
, Inflammatory process in the THY-Tau22 mice model. Society of neurosciences Abstract, p.2011, 2011.
, Physical Activity and Risk of Cognitive Impairment and Dementia in Elderly Persons, Archives of Neurology, vol.58, issue.3, pp.498-504, 2001.
, Activity of adenosine receptors type 1 Is required for CX3CL1mediated neuroprotection and neuromodulation in hippocampal neurons, Journal of immunology, vol.180, pp.7590-7596, 1950.
, Chemokine receptor CXCR2 regulates the functional properties of AMPA-type glutamate receptor GluR1 in HEK cells, Journal of Neuroimmunology, vol.129, pp.66-73, 2002.
, Detrimental effects of diet-induced obesity on ? pathology are independent of insulin resistance in ? transgenic mice, Diabetes, vol.62, pp.1681-1689, 2013.
, 100 years of consolidation-remembering Müller and Pilzecker. Learning & memory, vol.6, pp.77-87, 1999.
, Insulin rescues amyloid ?-induced impairment of hippocampal longterm potentiation, Neurobiology of Aging, vol.30, pp.377-387, 2009.
DOI : 10.1016/j.neurobiolaging.2007.06.014
, Insulin promotes dendritic spine and synapse formation by the PI3K/Akt/mTOR and Rac1 signaling pathways, Neuropharmacology, issue.4, pp.867-879, 2011.
DOI : 10.1016/j.neuropharm.2011.06.003
, LPS-induced inflammation exacerbates phospho-tau pathology in rTg4510 mice, Journal of neuroinflammation, vol.7, p.56, 2010.
DOI : 10.1186/1742-2094-7-56
URL : https://jneuroinflammation.biomedcentral.com/track/pdf/10.1186/1742-2094-7-56
, Tau interacts with src-family non-receptor tyrosine kinases, Journal of cell science, vol.111, issue.2, pp.3167-3177, 1998.
, NMDA induces long-term synaptic depression and dephosphorylation of the GluR1 subunit of AMPA receptors in hippocampus, Neuron, vol.21, issue.5, pp.1151-1162, 1998.
, Synaptic plasticity and phosphorylation, Pharmacology and Therapeutics, vol.112, pp.810-832, 2006.
, CX3CR1 deficiency alters microglial activation and reduces beta-amyloid deposition in two Alzheimer's disease mouse models. The American journal of pathology, vol.177, pp.2549-2562, 2010.
DOI : 10.2353/ajpath.2010.100265
URL : http://europepmc.org/articles/pmc2966811?pdf=render
, CCR5 deficiency induces astrocyte activation, Abeta deposit and impaired memory function, Neurobiology of Learning and Memory, vol.92, issue.3, pp.356-363, 2009.
DOI : 10.1016/j.nlm.2009.04.003
, Lack of Tau Proteins Rescues Neuronal Cell Death and Decreases Amyloidogenic Processing of APP in APP/PS1 Mice, The American Journal of Pathology, vol.181, issue.6, pp.1928-1940, 2012.
, Association between the macrophage inflammatory protein-l alpha gene polymorphism and Alzheimer's disease in the Chinese population, Neuroscience Letters, vol.433, issue.2, pp.125-128, 2008.
, Amyloid beta interaction with receptor for advanced glycation end products up-regulates brain endothelial CCR5 expression and promotes T cells crossing the blood-brain barrier, Journal of immunology, vol.182, issue.9, pp.5778-5788, 1950.
, Soluble A? oligomers inhibit long-term potentiation through a mechanism involving excessive activation of extrasynaptic NR2B-containing NMDA receptors, The Journal of neuroscience : the official journal of the Society for Neuroscience, issue.18, pp.6627-6638, 2011.
, Soluble Oligomers of Amyloid beta Protein Facilitate Hippocampal LongTerm Depression by Disrupting Neuronal Glutamate Uptake, Neuron, vol.62, issue.6, pp.788-801, 2009.
DOI : 10.1016/j.neuron.2009.05.012
URL : https://doi.org/10.1016/j.neuron.2009.05.012
, JNK1 contributes to metabotropic glutamate receptor-dependent longterm depression and short-term synaptic plasticity in the mice area hippocampal CA1, European Journal of Neuroscience, vol.25, issue.2, pp.391-396, 2007.
DOI : 10.1111/j.1460-9568.2006.05300.x
, Interleukin-1 mediates pathological effects of microglia on tau phosphorylation and on synaptophysin synthesis in cortical neurons through a p38MAPK pathway, The Journal of neuroscience : the official journal of the Society for Neuroscience, vol.23, issue.5, pp.1605-1611, 2003.
, Tumor necrosis factor-alpha, interleukin-1beta, and interferon-gamma stimulate gamma-secretase-mediated cleavage of amyloid precursor protein through a JNK-dependent MAPK pathway, Journal of Biological Chemistry, vol.279, issue.47, pp.49523-49532, 2004.
, A Cxcl12-Cxcr4 chemokine signaling pathway defines the initial trajectory of mammalian motor axons, Neuron, vol.47, issue.5, pp.667-679, 2005.
, Ibuprofen effects on Alzheimer pathology and open field activity in APPsw transgenic mice, Neurobiology of Aging, vol.22, issue.6, pp.983-991, 2001.
DOI : 10.1016/s0197-4580(01)00299-8
, Ibuprofen suppresses plaque pathology and inflammation in a mouse model for Alzheimer's disease. The Journal of neuroscience : the official journal of the Society for, Neuroscience, vol.20, issue.15, pp.5709-5714, 2000.
DOI : 10.1523/jneurosci.20-15-05709.2000
URL : http://www.jneurosci.org/content/20/15/5709.full.pdf
, Chemokine CX3CL1 protects rat hippocampal neurons against glutamate-mediated excitotoxicity, Journal of Neuroimmunology, vol.166, pp.19-28, 2005.
DOI : 10.1016/j.jneuroim.2005.03.023
, PICK1 and phosphorylation of the glutamate receptor 2 (GluR2) AMPA receptor subunit regulates GluR2 recycling after NMDA receptorinduced internalization, The Journal of neuroscience : the official journal of the Society for Neuroscience, vol.27, issue.50, pp.13903-13908, 2007.
, Participation of postsynaptic PKC in cerebellar LTD in culture, Science, vol.254, pp.1656-1659, 1991.
, Protein kinase M? enhances excitatory synaptic transmission by increasing the number of active postsynaptic AMPA receptors, Hippocampus, vol.16, pp.443-452, 2006.
, A mechanism for the Hebb and the anti-Hebb processes underlying learning and memory, Proceedings of the National Academy of Sciences of the United States of America, vol.86, pp.9574-9578, 1989.
, The molecular basis of CaMKII function in synaptic and behavioural memory, Nature reviews. Neuroscience, vol.3, issue.3, pp.175-190, 2002.
, Mechanisms of CaMKII action in longterm potentiation, Nature Reviews Neuroscience, vol.29, issue.6, pp.997-1003, 2012.
, Neuroinflammation in Alzheimer's disease: chemokines produced by astrocytes and chemokine receptors, International journal of clinical and experimental pathology, vol.7, issue.12, pp.8342-55, 2014.
, Deficient brain insulin signalling pathway in Alzheimer's disease and diabetes, The Journal of pathology, vol.225, issue.1, pp.54-62, 2011.
DOI : 10.1002/path.2912
URL : http://europepmc.org/articles/pmc4484598?pdf=render
, Identification of nuclear tau isoforms in human neuroblastoma cells, Proc Natl Acad Sci U S A, vol.87, issue.21, pp.8422-8426, 1990.
, Interleukin-1 receptor antagonist exerts agonist activity in the hippocampus independent of the interleukin-1 type I receptor, Journal of Neuroimmunology, vol.137, issue.1-2, pp.117-124, 2003.
, The ventral hippocampus is necessary for expressing a spatial memory, Brain Structure and Function, vol.217, issue.1, pp.93-106, 2012.
DOI : 10.1007/s00429-011-0332-y
, Protein kinase C inhibitors eliminate hippocampal long-term potentiation, Brain research, vol.436, issue.1, pp.177-183, 1987.
DOI : 10.1016/0006-8993(87)91573-3
, Relation of diabetes to mild cognitive impairment, Archives of neurology, vol.64, issue.4, pp.570-575, 2007.
, Adiposity, hyperinsulinemia, diabetes and Alzheimer's disease, European Journal of Pharmacology, vol.585, issue.1, pp.119-129, 2008.
DOI : 10.1016/j.ejphar.2008.02.048
URL : http://europepmc.org/articles/pmc2474785?pdf=render
, Inflammatory repertoire of Alzheimer's disease and nondemented elderly microglia in vitro, Glia, vol.35, issue.1, pp.72-79, 2001.
DOI : 10.1002/glia.1072
, NMDA receptor-dependent long-term potentiation and long-term depression (LTP/LTD). Cold Spring Harbor Perspectives in Biology, vol.4, pp.1-15, 2012.
, Intracellular injections of EGTA block induction of hippocampal longterm potentiation, Nature, issue.5936, pp.719-721, 1983.
, Fractalkine-induced activation of the phosphatidylinositol-3 kinase pathway attentuates microglial activation in vivo and in vitro, Journal of Neurochemistry, vol.110, issue.5, pp.1547-1556, 2009.
,
, Curcumin suppresses soluble Tau dinners and corrects molecular chaperone, synaptic, and behavioral deficits in aged human Tau transgenic mice, Journal of Biological Chemistry, vol.288, issue.6, pp.4056-4065, 2013.
, Differing presynaptic contributions to LTP and associative learning in behaving mice, Frontiers in behavioral neuroscience, vol.3, p.7, 2009.
, LTP impairment by fractalkine/CX3CL1 in mouse hippocampus is mediated through the activity of adenosine receptor type 3 (A3R), Journal of Neuroimmunology, vol.215, issue.1-2, pp.36-42, 2009.
, Production et sécrétion de l'insuline par la cellule ? pancréatique, EMC-Endocrinologie, vol.2, issue.4, pp.241-264, 2005.
, Interaction of tau protein with the dynactin complex, The EMBO journal, vol.26, issue.21, pp.4546-4554, 2007.
, LTP and LTD: An embarrassment of riches, Neuron, vol.44, issue.1, pp.5-21, 2004.
, NMDA-receptor-dependent synaptic plasticity: Multiple forms and mechanisms, Trends in Neurosciences, vol.16, issue.12, pp.521-527, 1993.
DOI : 10.1016/0166-2236(93)90197-t
, Inhibition of postsynaptic PKC or CaMKII blocks induction but not expression of LTP, Science, issue.4920, pp.862-866, 1989.
, Phosphorylation of the ?-amino-3-hydroxy-5-methylisoxazole-4propionic Acid receptor GluR1 subunit by calcium/calmodulin-dependent kinase II, Journal of Biological Chemistry, vol.272, issue.51, pp.32528-32533, 1997.
, Regulation of AMPA receptor-mediated synaptic transmission by clathrin-dependent receptor internalization, Neuron, vol.25, pp.649-662, 2000.
, Peripheral T cells overexpress MIP-1? to enhance its transendothelial migration in Alzheimer's disease, Neurobiology of Aging, vol.28, pp.485-496, 2007.
, Clogging of axons by tau, inhibition of axonal traffic and starvation of synapses, Neurobiology of Aging, vol.24, issue.8, pp.1079-1085, 2003.
, Reactive microglia drive tau pathology and contribute to the spreading of pathological tau in the brain, Brain, pp.1738-1755, 2015.
, Insulin in the cerebrospinal fluid, Nature, vol.215, issue.5108, pp.1375-1381, 1967.
, The H1 haplotype of the tau gene (MAPT) is associated with mild cognitive impairment, Journal of Alzheimer's disease : JAD, vol.19, issue.3, pp.909-923, 2010.
, S YNAPTIC P LASTICITY AND MEMORY: An Evaluation of the Hypothesis. Annual review of neuroscience, pp.649-711, 1949.
, Electrophoretic resolution of three major insulin receptor structures with unique subunit stoichiometries, Proceedings of the National Academy of Sciences of the United States of America, vol.77, pp.7137-7141, 1980.
, Interleukin-6 prevents ischemia-induced learning disability and neuronal and synaptic loss in gerbils, Neuroscience Letters, vol.204, issue.1-2, pp.109-112, 1996.
, Phosphorylation of serine-880 in GluR2 by protein kinase C prevents its C terminus from binding with glutamate receptorinteracting protein, Journal of Neurochemistry, vol.73, issue.4, pp.1765-1768, 1999.
, Effects of intrahippocampal CT105, a carboxyl terminal fragment of ??-amyloid precursor protein, alone/with inflammatory cytokines on working memory in rats, Journal of Neurochemistry, vol.82, issue.2, pp.234-239, 2002.
, Involvement of arachidonic acid cascade in working memory impairment induced by interleukin-1 beta, Neuropharmacology, vol.46, issue.8, pp.1195-1200, 2004.
, Cellular actions of beta-amyloid precursor protein and its soluble and fibrillogenic derivatives, Physiological reviews, vol.77, issue.4, pp.1081-1132, 1997.
, CCR5 Knockout Prevents Neuronal Injury and Behavioral Impairment Induced in a Transgenic Mouse Model by a CXCR4-Using HIV-1 Glycoprotein 120, The Journal of Immunology, vol.193, issue.4, pp.1895-1910, 2014.
, Voltage-dependent block by Mg2+ of NMDA responses in spinal cord neurones, Nature, vol.309, issue.5965, pp.261-263, 1984.
, The apolipoprotein epsilon 4 allele in patients with Alzheimer's disease, Annals of neurology, vol.34, issue.5, pp.752-754, 1993.
, Degradation of Alzheimer's ß-Amyloid Protein by Human and Rat Brain Peptidases: Involvement of Insulin-Degrading Enzyme, Neurochemical research, vol.22, issue.1, pp.49-56, 1997.
, Multiple memory systems: The power of interactions, Neurobiology of Learning and Memory, vol.82, issue.3, pp.333-346, 2004.
, The role of the dorsal and ventral hippocampus in fear and memory of a shock-probe experience, Brain Research, pp.185-194, 2009.
, NSAIDs and Alzheimer disease: Epidemiological, animal model and clinical studies, Neurobiology of Aging, vol.28, issue.5, pp.639-647, 2007.
, Arthritis and anti-inflammatory agents as possible protective factors for Alzheimer's disease: a review of 17 epidemiologic studies, Neurology, vol.47, issue.2, pp.425-432, 1996.
, Brain tissue oxygen amperometry in behaving rats demonstrates functional dissociation of dorsal and ventral hippocampus during spatial processing and anxiety, European Journal of Neuroscience, vol.33, issue.2, pp.322-337, 2011.
, Chemokines and neuromodulation, Journal of Neuroimmunology, pp.62-68, 0198.
, Mice overexpressing chemokine ligand 2 (CCL2) in astrocytes display enhanced nociceptive responses, Neuroscience, vol.149, issue.3, pp.706-714, 2007.
, Systemic administration of kainic acid in adult rat stimulates expression of the chemokine receptor CCR5 in the forebrain, Glia, vol.37, issue.2, pp.124-138, 2002.
, Chemokines regulate hippocampal neuronal signaling and gp120 neurotoxicity, Proceedings of the National Academy of Sciences of the United States of America, vol.95, issue.24, pp.14500-14505, 1998.
, PKMzeta maintains memories by regulating GluR2-dependent AMPA receptor trafficking, Nature neuroscience, vol.13, issue.5, pp.630-634, 2010.
, Anorexia and adipsia: Dissociation from fever after MIP-1 injection in ventromedial hypothalamus and preoptic area of rats, Brain Research Bulletin, vol.27, issue.2, pp.273-278, 1991.
, Fever induced by macrophage inflammatory protein-1 (MIP-1) in rats: Hypothalamic sites of action, Brain Research Bulletin, vol.27, issue.5, pp.701-706, 1991.
, Contextual learning requires synaptic AMPA receptor delivery in the hippocampus, Proceedings of the National Academy of Sciences of the United States of America, vol.108, pp.12503-12508, 2011.
, The biphasic role of microglia in Alzheimer's disease, International Journal of Alzheimer's Disease, 2012.
, Early Phenotypic Changes in Transgenic Mice That Overexpress Different Mutants of Amyloid Precursor Protein in Brain, The Journal of biological chemistry, vol.274, issue.10, pp.6483-6492, 1999.
, Sustained expression of interleukin-1? in mouse hippocampus impairs spatial memory, Neuroscience, vol.164, issue.4, pp.1484-1495, 2009.
, The Many Faces of Tau, Neuron, vol.70, issue.3, pp.410-426, 2011.
, Spatial learning impairment parallels the magnitude of dorsal hippocampal lesions, but is hardly present following ventral lesions, The Journal of neuroscience : the official journal of the Society for Neuroscience, vol.13, issue.9, pp.3916-3925, 1993.
, Spatial learning with a minislab in the dorsal hippocampus, Proceedings of the National Academy of Sciences of the United States of America, vol.92, pp.9697-9701, 1995.
, Functional differentiation in the hippocampus, Hippocampus, vol.8, issue.6, pp.608-619, 1998.
, Co-activation of p38 mitogen-activated protein kinase and protein tyrosine phosphatase underlies metabotropic glutamate receptor-dependent long-term depression, The Journal of physiology, vol.586, issue.10, pp.2499-2510, 2008.
, Tyrosine phosphatases regulate AMPA receptor trafficking during metabotropic glutamate receptor-mediated long-term depression, The Journal of neuroscience, vol.26, issue.9, pp.2544-2554, 2006.
, Role of metabotropic glutamate receptors in persistent forms of hippocampal plasticity and learning, Neuropharmacology, vol.66, pp.65-81, 2013.
, Involvement of a calcineurin/inhibitor-1 phosphatase cascade in hippocampal long-term depression, Nature, vol.369, issue.6480, pp.486-488, 1994.
, An essential role for protein phosphatases in hippocampal long-term depression, Science, issue.5124, pp.1051-1055, 1993.
, Mechanisms underlying induction of homosynaptic long-term depression in area CA1 of the hippocampus, Neuron, vol.9, issue.5, pp.967-975, 1992.
, Induction of stable long-term potentiation in the presence of the protein kinase C antagonist staurosporine, Neuroscience letters, vol.135, issue.1, pp.18-22, 1992.
, RANTES modulates the release of glutamate in human neocortex, The Journal of neuroscience : the official journal of the Society for Neuroscience, vol.28, issue.28, pp.12231-12240, 2008.
, The H1c haplotype at the MAPT locus is associated with Alzheimer's disease, Human Molecular Genetics, vol.14, issue.16, pp.2399-2404, 2005.
, Fever and feeding: differential actions of macrophage inflammatory protein-1 (MIP-1), MIP-1 alpha and MIP-1 beta on rat hypothalamus, Neurochemical research, vol.18, issue.6, pp.667-673, 1993.
, Spatial cognition and the hippocampus: the anterior-posterior axis, Journal of cognitive neuroscience, vol.25, issue.1, pp.22-28, 2013.
, Increased expression of the gamma-secretase components presenilin-1 and nicastrin in activated astrocytes and microglia following traumatic brain injury, Glia, vol.56, issue.5, pp.552-567, 2008.
, Pharmacological antagonism of metabotropic glutamate receptor 1 regulates long-term potentiation and spatial reference memory in the dentate gyrus of freely moving rats via N-methyl-D-aspartate and metabotropic glutamate receptor-dependent mechanisms, European Journal of Neuroscience, vol.21, issue.2, pp.411-421, 2005.
, Regulation by Metabotropic Glutamate Receptor 5 of LTP in the Dentate Gyrus of Freely Moving Rats: Relevance for Learning and Memory Formation, Cerebral Cortex, vol.14, issue.2, pp.189-198, 2004.
, Maintenance of late-phase LTP is accompanied by PKA-dependent increase in AMPA receptor synthesis, Nature, vol.394, issue.6694, pp.680-683, 1998.
, Hyperphosphorylation of tau and neurofilaments and activation of CDK5 and ERK1/2 in PTEN-deficient cerebella, Molecular and Cellular Neuroscience, vol.34, issue.3, pp.400-408, 2007.
, Altered hippocampal synaptic transmission in transgenic mice with astrocyte-targeted enhanced CCL2 expression, Brain, Behavior, and Immunity, vol.25, pp.106-119, 2011.
, Altered synaptic transmission in the hippocampus of transgenic mice with enhanced central nervous systems expression of interleukin-6, Brain, Behavior, and Immunity, vol.26, issue.6, pp.959-971, 2012.
, Synaptic plasticity, memory and the hippocampus: a neural network approach to causality, Nature reviews. Neuroscience, vol.9, issue.1, pp.65-75, 2008.
, Metabotropic glutamate receptor 1 (mGluR1) and 5 (mGluR5) regulate late phases of LTP and LTD in the hippocampal CA1 region in vitro, European Journal of Neuroscience, vol.27, issue.6, pp.1345-1352, 2008.
, CXCL12 inhibits expression of the NMDA receptor's NR2B subunit through a histone deacetylase-dependent pathway contributing to neuronal survival, Cell death & disease, vol.1, p.33, 2010.
, PAR-1 kinase plays an initiator role in a temporally ordered phosphorylation process that confers tau toxicity in Drosophila, Cell, vol.116, issue.5, pp.671-682, 2004.
, Insulin activation of phosphatidylinositol 3-kinase in the hypothalamic arcuate nucleus: A key mediator of insulin-induced anorexia, Diabetes, vol.52, issue.2, pp.227-231, 2003.
, Magnesium gates glutamate-activated channels in mouse central neurones, Nature, vol.307, issue.5950, pp.462-465, 1984.
, A review of the hippocampal place cells, Progress in Neurobiology, vol.13, issue.4, pp.419-439, 1979.
, The hippocampus as a spatial map. Preliminary evidence from unit activity in the freely-moving rat, Brain research, vol.34, issue.1, pp.171-175, 1971.
, Decreasing hypothalamic insulin receptors causes hyperphagia and insulin resistance in rats, Nature neuroscience, vol.5, issue.6, pp.566-572, 2002.
, Extrasynaptic membrane trafficking regulated by GluR1 serine 845 phosphorylation primes AMPA receptors for long-term potentiation, Journal of Biological Chemistry, vol.281, issue.2, pp.752-758, 2006.
, Interleukin-1 beta, but not interleukin-6, impairs spatial navigation learning, Brain research, vol.613, issue.1, pp.160-163, 1993.
, Two distinct forms of long-term depression coexist in CA1 hippocampal pyramidal cells, Neuron, vol.18, issue.6, pp.969-982, 1997.
URL : https://hal.archives-ouvertes.fr/inserm-00000073
, Megalin is an endocytic receptor for insulin, Journal of the American Society of Nephrology : JASN, vol.9, issue.10, pp.1759-66, 1998.
, Protein synthesis-dependent formation of protein kinase Mzeta in longterm potentiation, The Journal of neuroscience : the official journal of the Society for Neuroscience, vol.16, issue.8, pp.2444-2451, 1996.
, The role of astrocytes in the regulation of synaptic plastisity and memory formation.pdf, Neural plasticity, pp.1-11, 2013.
, Inhibition of the cAMP pathway decreases early long-term potentiation at CA1 hippocampal synapses, The Journal of neuroscience : the official journal of the Society for Neuroscience, vol.20, issue.12, pp.4446-4451, 2000.
, Association of diabetes mellitus and dementia: The Rotterdam Study, Diabetologia, vol.39, pp.1392-1397, 1996.
, Hippocalcin functions as a calcium sensor in hippocampal LTD, Neuron, vol.47, issue.4, pp.487-494, 2005.
, Insulin Has Multiple Antiamyloidogenic Effects on Human Neuronal Cells, Endocrinology, vol.154, issue.1, pp.375-387, 2013.
, Human insulin receptor monoclonal antibody undergoes high affinity binding to human brain capillaries in vitro and rapid transcytosis through the blood-brain barrier in vivo in the primate, Current opinion in pharmacology, vol.7, issue.1, pp.807-816, 1995.
, Intracerebroventricular insulin enhances memory in a passiveavoidance task, Physiology and Behavior, vol.68, issue.4, pp.509-514, 2000.
, Role of the macrophage inflammatory protein-1alpha/CC chemokine receptor 5 signaling pathway in the neuroinflammatory response and cognitive deficits induced by beta-amyloid peptide, The American journal of pathology, vol.175, issue.4, pp.1586-1597, 2009.
, LTP Inhibits LTD in the Hippocampus via Regulation of GSK3?, Neuron, vol.53, issue.5, pp.703-717, 2007.
URL : https://hal.archives-ouvertes.fr/inserm-00776885
, The role of GSK-3 in synaptic plasticity, British journal of pharmacology, vol.153, pp.428-437, 2007.
URL : https://hal.archives-ouvertes.fr/inserm-00777058
, GLIA modulates synaptic transmission, Brain research reviews, vol.63, issue.1-2, pp.93-102, 2010.
, Degradation of soluble amyloid ?-peptides 1-40, 1-42, and the Dutch variant 1-40Q by insulin degrading enzyme from Alzheimer disease and control brains, Neurochemical Research, vol.25, issue.2, pp.247-255, 2000.
, PICK1 targets activated protein kinase Calpha to AMPA receptor clusters in spines of hippocampal neurons and reduces surface levels of the AMPA-type glutamate receptor subunit 2, The Journal of neuroscience : the official journal of the Society for Neuroscience, vol.21, issue.15, pp.5417-5428, 2001.
, GSK-3alpha regulates production of Alzheimer's disease amyloid-beta peptides, Nature, issue.2, pp.435-439, 2003.
, CX3CL1-induced modulation at CA1 synapses reveals multiple mechanisms of EPSC modulation involving adenosine receptor subtypes, Journal of Neuroimmunology, vol.224, issue.1-2, pp.85-92, 2010.
, Projections from the lateral, basal, and accessory basal nuclei of the amygdala to the hippocampal formation in rat, The Journal of Comparative Neurology, vol.403, issue.2, pp.229-260, 1999.
, Cognitive impairment following high fat diet consumption is associated with brain inflammation, Journal of neuroimmunology, vol.219, issue.1-2, pp.25-32, 2010.
, Astrocytes: Orchestrating synaptic plasticity? Neuroscience, 2015.
, Insulin in the cerebrospinal fluid, Neuroscience and biobehavioral reviews, vol.15, issue.2, pp.243-258, 1991.
, Dependence of food intake on acute and chronic ventricular administration of insulin, Physiology & behavior, vol.37, pp.717-734, 1986.
, Enhanced leptin-stimulated Pi3k activation in the CNS promotes white adipose tissue transdifferentiation, Cell metabolism, vol.6, issue.6, pp.431-476, 2007.
, Enhanced PIP3 signaling in POMC neurons causes KATP channel activation and leads to diet-sensitive obesity, Journal of Clinical Investigation, vol.116, issue.7, pp.1886-1901, 2006.
, Age-dependent impairment of cognitive and synaptic function in the htau mouse model of tau pathology, The Journal of neuroscience : the official journal of the Society for Neuroscience, vol.29, issue.34, pp.10741-10749, 2009.
, Dissociation of function between the dorsal and the ventral hippocampus in spatial learning abilities of the rat: A within-subject, within-task comparison of reference and working spatial memory, European Journal of Neuroscience, vol.19, issue.3, pp.705-712, 2004.
, Place cells in the ventral hippocampus of rats, NeuroReport, vol.5, issue.16, pp.2045-2048, 1994.
URL : https://hal.archives-ouvertes.fr/hal-01385331
, Role of interleukin-1 beta in impariment of contextual fear conditioning caused by social isolation, Behav Brain Res, vol.106, pp.109-118, 1999.
, The chemokine SDF-1 differentially regulates axonal elongation and branching in hippocampal neurons, Journal of cell science, vol.118, pp.1071-1080, 2005.
, CELL BIOLOGY AND METABOLISM : Insulin-degrading Enzyme Regulates Extracellular Levels of Amyloid ?-Protein by Degradation Insulin-degrading Enzyme Regulates Extracellular Levels of Amyloid ?-Protein by Degradation *, vol.273, pp.32730-32738, 1998.
, Chemokine fractalkine/CX3CL1 negatively modulates active glutamatergic synapses in rat hippocampal neurons, The Journal of neuroscience : the official journal of the Society for Neuroscience, vol.26, issue.41, pp.10488-10498, 2006.
, RAGE: therapeutic target and biomarker of the inflammatory response-the evidence mounts, Journal of leukocyte biology, vol.86, issue.3, pp.505-512, 2009.
, Histologie du système nerveux de l ' homme et des vertébrés , par S . Ramon Cajal, p.1911, 1911.
, Insulin signaling effects on memory and mood, Current Opinion in Pharmacology, vol.7, issue.6, pp.633-637, 2007.
, Short-term presynaptic plasticity, Cold Spring Harbor Perspectives in Biology, vol.4, issue.7, pp.1-19, 2012.
, Intranasal insulin administration dose-dependently modulates verbal memory and plasma amyloid-beta in memory-impaired older adults, Journal of Alzheimer's disease, vol.13, issue.3, pp.323-354, 2008.
, Effects of intranasal insulin on cognition in memory-impaired older adults: Modulation by APOE genotype, Neurobiology of Aging, vol.27, issue.3, pp.451-458, 2006.
, Intranasal insulin improves cognition and modulates-amyloid in early AD, Neurology, vol.70, issue.6, pp.440-448, 2008.
, PKC? is critical in AMPA receptor phosphorylation and synaptic incorporation during LTP, The EMBO journal, vol.32, issue.10, pp.1365-80, 2013.
, Phosphorylation regulates tau interactions with Src homology 3 domains of phosphatidylinositol 3-kinase, phospholipase C?1, Grb2, and Src family kinases, Journal of Biological Chemistry, vol.283, issue.26, pp.18177-18186, 2008.
, Bibliothèque numérique. , (c), p.1888
, Akt activity in Alzheimer ' s disease and other neurodegenerative disorders, Neurochemistry, vol.15, issue.6, pp.955-959, 2004.
, PTEN levels in Alzheimer's disease medial temporal cortex, Neurochemistry International, vol.48, pp.114-123, 2006.
, Reducing endogenous tau ameliorates amyloid beta-induced deficits in an Alzheimer's disease mouse model, Science, issue.5825, pp.750-754, 2007.
, Transient activation of cyclic AMP-dependent protein kinase during hippocampal long-term potentiation, The Journal of biological chemistry, vol.271, issue.48, pp.30436-30441, 1996.
, Characterization of multiple phosphorylation sites on the AMPA receptor GluR1 subunit, Neuron, vol.16, issue.6, pp.1179-1188, 1996.
, Lipopolysaccharide-induced tau phosphorylation and kinase activitymodulation, but not mediation, by corticotropin-releasing factor receptors, European Journal of Neuroscience, vol.34, issue.3, pp.448-456, 2011.
, Expression of immune system-associated antigens by cells of the human central nervous system: Relationship to the pathology of Alzheimer's disease, Neurobiology of Aging, vol.9, pp.339-349, 1988.
, CX3CR1 Deficiency Leads to Impairment of Hippocampal Cognitive Function and Synaptic Plasticity, Journal of Neuroscience, vol.31, issue.45, pp.16241-16250, 2011.
, Age-dependent spatial memory loss can be partially restored by immune activation, Rejuvenation research, vol.11, issue.5, pp.903-913, 2008.
, LTP promotes a selective long-term stabilization and clustering of dendritic spines, PLoS Biology, vol.6, issue.9, pp.1850-1860, 2008.
, A dual role for interleukin-1 in LTP in mouse hippocampal slices, Journal of Neuroimmunology, vol.144, issue.1-2, pp.61-67, 2003.
, The biology of chemokines and their receptors, Annual review of immunology, vol.18, pp.217-242, 2000.
, Caffeine: neuroprotective functions in cognition and Alzheimer's disease. American journal of Alzheimer's disease and other dementias, vol.23, pp.417-422, 2008.
, Chemokines and chemokine receptors: New actors in neuroendocrine regulations, Frontiers in Neuroendocrinology, vol.32, issue.1, pp.10-24, 2011.
, Chemokines and chemokine receptors: New actors in neuroendocrine regulations, Frontiers in Neuroendocrinology, vol.32, pp.10-24, 2011.
, Neurochemokines: A menage a trois providing new insights on the functions of chemokines in the central nervous system, Journal of Neurochemistry, vol.118, pp.680-694, 2011.
, Chemokines as modulators of neuroendocrine functions, Journal of Molecular Endocrinology, vol.38, pp.351-353, 2007.
, Chemokines: a new class of neuromodulator?, Nature reviews. Neuroscience, vol.8, pp.895-903, 2007.
, Group I metabotropic glutamate receptor (mGluR)-dependent longterm depression mediated via p38 mitogen-activated protein kinase is inhibited by previous high-frequency stimulation and activation of mGluRs and protein kinase C in the rat dentate gyrus in, The Journal of neuroscience, vol.22, issue.14, pp.6121-6129, 2002.
, Chapter 2 PKMzeta, LTP maintenance, and the dynamic molecular biology of memory storage, 2008.
, Gonadotropin-Releasing Hormone-Expressing Neurons Immortalized Conditionally Are Activated by Insulin: Implication of the Mitogen-Activated Protein Kinase Pathway, Endocrinology, vol.147, issue.2, pp.816-826, 2006.
, Cxcr7 Controls Neuronal Migration by Regulating Chemokine Responsiveness, Neuron, vol.69, issue.1, pp.77-90, 2011.
, Phosphatidylinositol 3-kinase is required for the expression but not for the induction or the maintenance of long-term potentiation in the hippocampal CA1 region, The Journal of neuroscience : the official journal of the Society for Neuroscience, vol.22, issue.9, pp.3359-3365, 2002.
, Leptin Affects Insulin Action in Astrocytes and Impairs Insulinmediated Physical Activity. Cellular Physiology and Biochemistry, vol.30, pp.238-246, 2012.
, Mediterranean diet, alzheimer disease, and vascular mediation, vol.63, pp.1709-1717, 2006.
, Alzheimer's disease-like tau neuropathology leads to memory deficits and loss of functional synapses in a novel mutated tau transgenic mouse without any motor deficits. The American journal of pathology, vol.169, pp.599-616, 2006.
, Increased amyloid beta-peptide deposition in cerebral cortex as a consequence of apolipoprotein E genotype in late-onset Alzheimer disease, Proceedings of the National Academy of Sciences of the United States of America, vol.90, pp.9649-9653, 1993.
, The effects of IL-1 receptor antagonist on beta amyloid mediated depression of LTP in the rat CA1 in vivo, Hippocampus, vol.19, issue.7, pp.670-676, 2009.
, A neuromodulatory role of interleukin-1beta in the hippocampus, Proceedings of the National Academy of Sciences of the United States of America, vol.95, pp.7778-7783, 1998.
, Regional and cellular localization of the CXCl12/SDF-1 chemokine receptor CXCR7 in the developing and adult rat brain, The Journal of comparative neurology, vol.510, issue.2, pp.207-220, 2008.
, Insulin receptor substrate-2 deficiency impairs brain growth and promotes tau phosphorylation, The Journal of neuroscience : the official journal of the Society for Neuroscience, vol.23, issue.18, pp.7084-7092, 2003.
, Role for neuronal insulin resistance in neurodegenerative diseases, Proceedings of the National Academy of Sciences of the United States of America, vol.101, issue.9, pp.3100-3105, 2004.
, Central nervous system control of food intake, Nature, vol.404, issue.6778, pp.661-71, 2000.
DOI : 10.1038/35007534
, Insulin binding to brain capillaries is reduced in genetically obese, hyperinsulinemic Zucker rats, Peptides, vol.11, issue.3, pp.467-72, 1990.
DOI : 10.1016/0196-9781(90)90044-6
, Fractalkine (CX3CL1) enhances hippocampal N-methyl-D-aspartate receptor (NMDAR) function via D-serine and adenosine receptor type A2 (A2AR) activity, Journal of neuroinflammation, vol.10, issue.1, p.108, 2013.
DOI : 10.1186/1742-2094-10-108
URL : https://hal.archives-ouvertes.fr/pasteur-01053841
, Differences in the abilities of human tau isoforms to promote microtubule assembly, Journal of neuroscience research, vol.30, issue.1, pp.154-162, 1991.
, Loss of recent memory after bilateral hippocampal lesions, The Journal of neuropsychiatry and clinical neurosciences, vol.12, issue.1, pp.103-113, 1957.
DOI : 10.1093/neucas/2.4.259-af
, Dendritic spines and long-term plasticity, Nature reviews. Neuroscience, vol.6, issue.4, pp.277-284, 2005.
DOI : 10.1038/nrn1649
, Alzheimer's disease is a synaptic failure, Science, issue.5594, pp.789-791, 2002.
, Biochemistry of Tau in Alzheimer's disease and related neuroogical disorders, Expert review of proteomics, vol.5, issue.2, pp.207-224, 2008.
, Independent functioning of verbal memory stores: a neuropsychological study, The Quarterly journal of experimental psychology, vol.22, issue.2, pp.261-273, 1970.
DOI : 10.1080/00335557043000203
URL : http://journals.sagepub.com/doi/pdf/10.1080/00335557043000203
, Natural oligomers of the Alzheimer amyloid-beta protein induce reversible synapse loss by modulating an NMDA-type glutamate receptor-dependent signaling pathway, The Journal of neuroscience : the official journal of the Society for Neuroscience, vol.27, issue.11, pp.2866-2875, 2007.
, Cytokines and cholinergic signals co-modulate surgical stressinduced changes in mood and memory, Brain, Behavior, and Immunity, vol.22, issue.3, pp.388-398, 2008.
DOI : 10.1016/j.bbi.2007.09.006
, Interleukin-1 promotes expression and phosphorylation of neurofilament and tau proteins in vivo, Experimental neurology, vol.163, issue.2, pp.388-391, 2000.
, Neuritic plaque evolution in Alzheimer's disease is accompanied by transition of activated microglia from primed to enlarged to phagocytic forms, Acta Neuropathologica, vol.94, issue.1, pp.1-5, 1997.
, CX3CL1 is up-regulated in the rat hippocampus during memoryassociated synaptic plasticity, Frontiers in Cellular Neuroscience, vol.8, pp.1-15, 2014.
DOI : 10.3389/fncel.2014.00233
URL : https://www.frontiersin.org/articles/10.3389/fncel.2014.00233/pdf
, Deficient hippocampal long-term potentiation in a-calciumcalmodulin kinase II mutant mice, Science, vol.257, pp.201-206, 1992.
DOI : 10.1126/science.1378648
, Presenilin-1 P264L knock-in mutation: differential effects on abeta production, amyloid deposition, and neuronal vulnerability, The Journal of neuroscience, vol.20, issue.23, pp.8717-8726, 2000.
DOI : 10.1016/s0197-4580(00)82329-5
, Astrocyte phenotype in relation to Alzheimer-type pathology in the ageing brain, Neurobiology of Aging, vol.31, issue.4, pp.578-590, 2010.
, Tau protein binds to pericentromeric DNA: a putative role for nuclear tau in nucleolar organization, Journal of cell science, vol.119, pp.2025-2034, 2006.
, Insulin promotes rapid delivery of N-methyl-D-aspartate receptors to the cell surface by exocytosis, Proceedings of the National Academy of Sciences of the United States of America, vol.98, pp.3561-3566, 2001.
, mGluR1-mediated potentiation of NMDA receptors involves a rise in intracellular calcium and activation of protein kinase C, Neuropharmacology, vol.40, issue.7, pp.856-865, 2001.
, The chemokine stromal cell-derived factor-1/CXCL12 activates the nigrostriatal dopamine system, Journal of Neurochemistry, vol.102, issue.4, pp.1175-1183, 2007.
URL : https://hal.archives-ouvertes.fr/hal-00171229
, Internalization of ionotropic glutamate receptors in response to mGluR activation, Nature neuroscience, vol.4, issue.11, pp.1079-1085, 2001.
, Regulation of NMDA receptor trafficking by amyloid-beta, Nature neuroscience, vol.8, issue.8, pp.1051-1058, 2005.
, Postsynaptic protein phosphorylation and LTP. LTP, Trends Neurosci, vol.23, pp.75-80, 2000.
, Astrocytes: Biology and pathology, Acta Neuropathologica, vol.119, issue.1, pp.7-35, 2010.
, Interleukin 1 beta enhances conditioned fear memory in rats: Possible involvement of glucocorticoids, European Journal of Neuroscience, vol.18, issue.7, pp.1739-1743, 2003.
, TLR4 mutation reduces microglial activation, increases A? deposits and exacerbates cognitive deficits in a mouse model of Alzheimer's disease, Journal of neuroinflammation, vol.8, issue.1, p.92, 2011.
, The functions and regulation of the PTEN tumour suppressor, Nature Reviews Molecular Cell Biology, vol.13, issue.5, pp.283-296, 2012.
, Accumulation of tumor-suppressor PTEN in Alzheimer neurofibrillary tangles, Neuroscience Letters, vol.471, pp.20-24, 2010.
, Regulation of the phosphorylation state and microtubule-binding activity of tau by protein phosphatase 2A, Neuron, vol.17, issue.6, pp.1201-1207, 1996.
, Phosphatase and tensin homologue (PTEN) regulates synaptic plasticity independently of its effect on neuronal morphology and migration, The Journal of Physiology, vol.590, issue.4, pp.777-792, 2012.
, Tau protein pathology in neurodegenerative diseases, Trends in Neurosciences, vol.21, issue.10, pp.428-433, 1998.
, The Intersection of Amyloid Beta and Tau at Synapses in Alzheimer's Disease, Neuron, vol.82, issue.4, pp.756-771, 2014.
, Deficient hippocampal insulin signaling and augmented Tau phosphorylation is related to obesity-and age-induced peripheral insulin resistance: a study in Zucker rats, BMC Neuroscience, vol.15, issue.1, p.111, 2014.
, Impaired long term memory consolidation in transgenic mice overexpressing the human soluble form of IL-1ra in the brain, Journal of Neuroimmunology, vol.208, issue.1-2, pp.46-53, 2009.
, Memory and the hippocampus: a synthesis from findings with rats, monkeys, and humans, Psychological review, vol.99, issue.2, pp.195-231, 1992.
, Memory systems of the brain: A brief history and current perspective, Neurobiology of Learning and Memory, vol.82, issue.3, pp.171-177, 2004.
, Memory systems. Comptes rendus de l'Académie des sciences. Série III, Sciences de la vie, vol.321, pp.153-159, 1998.
, The organization and neural substrates of human memory, Int.J Neurol, pp.218-222, 1987.
, The medial temporal lobe memory system, Science, issue.5026, pp.1380-1386, 1991.
, Coupling diverse routes of calcium entry to mitochondrial dysfunction and glutamate excitotoxicity, Proceedings of the National Academy of Sciences of the United States of America, vol.106, issue.24, pp.9854-9859, 2009.
, The paradox of neuronal insulin action and resistance in the development of aging-associated diseases, Alzheimer's & Dementia, vol.10, issue.1, pp.3-11, 2014.
, A brief perspective on insulin production, Diabetes, Obesity and Metabolism, vol.11, pp.189-196, 2009.
, Tau phosphorylation sites work in concert to promote neurotoxicity in vivo, Molecular biology of the cell, vol.18, issue.12, pp.5060-5068, 2007.
, Differential regulation of AMPA receptor and GABA receptor trafficking by tumor necrosis factor-alpha, The Journal of neuroscience : the official journal of the Society for Neuroscience, vol.25, issue.12, pp.3219-3228, 2005.
, An English translation of Alzheimer's 1907 paper, "uber eine eigenartige erkankung der hirnrinde, Clinical Anatomy, vol.8, issue.6, pp.429-431, 1995.
, A physiological mechanism for Hebb's postulate of learning, Proceedings of the National Academy of Sciences of the United States of America, vol.70, pp.997-1001, 1973.
, Influence of education and occupation on the incidence of Alzheimer's disease, JAMA : the journal of the American Medical Association, vol.271, issue.13, pp.1004-1010, 1994.
, Insulin and the CNS: Effects on food intake, memory, and endocrine parameters and the role of intranasal insulin administration in humans, Physiology and Behavior, vol.83, pp.47-54, 2004.
, Autophosphorylation-dependent targeting of calcium/ calmodulin-dependent protein kinase II by the NR2B subunit of the N-methyl-Daspartate receptor, The Journal of biological chemistry, vol.273, issue.33, pp.20689-20692, 1998.
, The anatomy of memory: an interactive overview of the parahippocampal-hippocampal network, Nature reviews. Neuroscience, vol.10, issue.4, pp.272-282, 2009.
, Insulin responses and glucose levels in plasma and cerebrospinal fluid during fasting and refeeding in the rat, Physiology & behavior, vol.44, issue.2, pp.205-213, 1988.
, Nuclear Tau, a key player in neuronal DNA protection, Journal of Biological Chemistry, vol.286, issue.6, pp.4566-4575, 2011.
, Mediobasal hypothalamic PTEN modulates hepatic insulin resistance independently of food intake in rats, American journal of physiology. Endocrinology and metabolism, vol.307, issue.1, pp.47-60, 2014.
, Dendritic Protein Synthesis, Synaptic Plasticity, and Memory, Cell, vol.127, issue.1, pp.49-58, 2006.
, Local translational control in dendrites and its role in long-term synaptic plasticity, Journal of Neurobiology, vol.64, issue.1, pp.116-131, 2005.
, An increased percentage of long amyloid beta protein secreted by familial amyloid beta protein precursor (beta APP717) mutants, Science, issue.5163, pp.1336-1340, 1994.
, Inflammation induced by infection potentiates tau pathological features in transgenic mice, American Journal of Pathology, vol.178, issue.6, pp.2811-2822, 2011.
, Heterologous desensitization of opioid receptors by chemokines inhibits chemotaxis and enhances the perception of pain, Proceedings of the National Academy of Sciences of the United States of America, vol.99, pp.10276-81, 2002.
, Reductions of acetylcholine release and nerve growth factor expression are correlated with memory impairment induced by interleukin-1?? administrations: Effects of omega-3 fatty acid EPA treatment, Journal of Neurochemistry, vol.112, issue.4, pp.1054-1064, 2010.
, Role of toll-like receptor signalling in Abeta uptake and clearance, Brain : a journal of neurology, vol.129, pp.3006-3019, 2006.
, Down-regulation of drebrin A expression suppresses synaptic targeting of NMDA receptors in developing hippocampal neurones, Journal of neurochemistry, vol.97, pp.110-115, 2006.
, Dysregulation of synaptic plasticity precedes appearance of morphological defects in a Pten conditional knockout mouse model of autism, Proceedings of the National Academy of Sciences, vol.110, pp.4738-4743, 2013.
, Ab induces astrocytic glutamate release, extrasynaptic NMDA receptor activation, and synaptic loss, Proceedings of the National Academy of Sciences, vol.110, issue.27, pp.2518-2527, 2013.
, Demonstrated brain insulin resistance in alzheimer's disease patients is assocaited with IGF-1 resisitance, IRS-1 dysregulation, and cogntive decline, Journal of clinical investigation, vol.122, issue.4, 2012.
, Critical nodes in signalling pathways: insights into insulin action, Nature reviews. Molecular cell biology, vol.7, issue.2, pp.85-96, 2006.
, Intracerebral Production of Tumor Necrosis Factor-A, a Local Neuroprotective Agent, in Alzheimer Disease and Vascular Dementia, Journal of clinical immunology, vol.19, issue.4, pp.223-230, 1999.
, Glial Regulation of Neuronal Function: From Synapse to Systems Physiology, 2012.
, Cell death or synaptic loss in Alzheimer disease, Journal of neuropathology and experimental neurology, vol.59, issue.12, pp.1118-1119, 2000.
, Critical role of astroglial apolipoprotein E and liver X receptor-? expression for microglial A? phagocytosis, The Journal of neuroscience : the official journal of the Society for Neuroscience, issue.19, pp.7049-7059, 2011.
, Changes in expressions of proinflammatory cytokines IL-1??, TNF-?? and IL-6 in the brain of senescence accelerated mouse (SAM) P8, Brain Research, vol.885, issue.1, pp.25-31, 2000.
, Phases of A beta-deposition in the human brain and its relevance for the development of AD, Neurology, vol.58, issue.12, pp.1791-1800, 2002.
, Tau as a nucleolar protein in human nonneural cells in vitro and in vivo, Chromosoma, vol.105, issue.1, pp.20-30, 1996.
, Occurrence of T cells in the brain of Alzheimer's disease and other neurological diseases, Journal of neuroimmunology, vol.124, issue.1-2, pp.83-92, 2002.
, The presenilin 2 mutation (N141I) linked to familial Alzheimer disease (Volga German families) increases the secretion of amyloid beta protein ending at the 42nd (or 43rd) residue, Proceedings of the National Academy of Sciences of the United States of America, vol.94, pp.2025-2030, 1997.
, Soluble Abeta Inhibits Specific Signal Transduction Cascades Common to the Insulin Receptor Pathway, Journal of Biological Chemistry, vol.282, issue.46, pp.33305-33312, 2007.
, Neurotrophins are required for nerve growth during development, Nature neuroscience, vol.4, issue.1, pp.29-37, 2001.
, Obesity in Aging Exacerbates Blood-Brain Barrier Disruption, Neuroinflammation, and Oxidative Stress in the Mouse Hippocampus: Effects on Expression of Genes Involved in Beta-Amyloid Generation and Alzheimer's Disease. The journals of gerontology. Series A, Biological sciences and medical sciences, Brain and cognition, vol.69, issue.8, pp.3-20, 1988.
,
, Quantitative targeted absolute proteomics of human blood-brain barrier transporters and receptors, Journal of Neurochemistry, vol.117, issue.2, pp.333-345, 2011.
, Hypothalamic inflammation in the control of metabolic function. Annual review of physiology, vol.77, pp.131-60, 2015.
, Glia-neuron intercommunications and synaptic plasticity, Progress in neurobiology, vol.49, pp.185-214, 1996.
, A major role for Tau in neuronal DNA and RNA protection in vivo under physiological and hyperthermic conditions, Frontiers in cellular neuroscience, vol.8, p.84, 2014.
, Inflammatory" cytokines' neuromodulators in normal brain, Journal of Neurochemistry, vol.74, issue.2, pp.457-471, 2000.
, Interleukin-1beta enhances NMDA receptor-mediated intracellular calcium increase through activation of the Src family of kinases, The Journal of neuroscience : the official journal of the Society for Neuroscience, vol.23, issue.25, pp.8692-8700, 2003.
, Developmental regulation of protein interacting with C kinase 1 (PICK1) function in hippocampal synaptic plasticity and learning, Proceedings of the National Academy of Sciences of the United States of America, vol.107, pp.21784-21789, 2010.
, PKM-zeta is not required for hippocampal synaptic plasticity, learning and memory, Nature, vol.493, issue.7432, pp.420-423, 2013.
, Naturally secreted oligomers of amyloid beta protein potently inhibit hippocampal long-term potentiation in vivo, Nature, issue.6880, pp.535-539, 2002.
, Role of the Toll-Like Receptor 4 in Neuro-inflammation in Alzheimer ' s Disease, Cellular Physiology and Biochemistry, vol.20, pp.947-956, 2007.
, Recruitment of functional GABA(A) receptors to postsynaptic domains by insulin, Nature, vol.388, pp.686-690, 1997.
, Postsynaptic protein kinase C essential to induction and maintenance of long-term potentiation in the hippocampal CA1 region, Proceedings of the National Academy of Sciences of the United States of America, vol.89, pp.2576-2580, 1992.
, Expression of cerebellar long-term depression requires postsynaptic clathrin-mediated endocytosis, Neuron, vol.25, pp.635-647, 2000.
, Macrophage Inflammatory Protein 2 Inhibits ?-Amyloid Peptide ( 1-42 )-Mediated Hippocampal Neuronal Apoptosis through Activation of Mitogen-Activated Protein Kinase and Phosphatidylinositol 3-Kinase Signaling Pathways, Molecular Pharmacology, vol.67, issue.3, pp.757-765, 2005.
, A protein factor essential for microtubule assembly, Proceedings of the National Academy of Sciences of the United States of America, vol.72, pp.1858-62, 1975.
, CCL2 is associated with a faster rate of cognitive decline during early stages of Alzheimer's disease, PLoS ONE, vol.7, issue.1, pp.1-6, 2012.
, Characterization of an endogenous substrate of the insulin receptor in cultured cells, Journal of Biological Chemistry, vol.262, pp.9769-9777, 1987.
, The IRS-signalling system: A network of docking proteins that mediate insulin action, Molecular and Cellular Biochemistry, vol.182, issue.1-2, pp.3-11, 1998.
, Multiple parallel memory systems in the brain of the rat, Neurobiology of learning and memory, vol.77, issue.2, pp.125-184, 2002.
, Learning induces long-term potentiation in the hippocampus, Science, issue.5790, pp.1093-1097, 2006.
, Regulation of receptor tyrosine kinase signaling by endocytic trafficking, Traffic, vol.2, issue.1, pp.12-18, 2001.
, ?-Secretase processing of APP inhibits neuronal activity in the hippocampus, Nature, vol.526, issue.7573, pp.443-447, 2015.
, Principles of Psychology. H. Holt and Company, 1890.
, Chemokines and the hippocampus: A new perspective on hippocampal plasticity and vulnerability, Brain, Behavior, and Immunity, vol.30, pp.186-194, 2013.
DOI : 10.1016/j.bbi.2013.01.077
, Rapid tyrosine phosphorylation of neuronal proteins including tau and focal adhesion kinase in response to amyloid-beta peptide exposure: involvement of Src family protein kinases, The Journal of neuroscience : the official journal of the Society for Neuroscience, vol.22, issue.1, pp.10-20, 2002.
, Insulin resistance in the brain: An oldage or new-age problem?, Biochemical Pharmacology, vol.84, issue.6, pp.737-745, 2012.
, Suppression of Alzheimer-Associated Inflammation by Microglial Prostaglandin-E2 EP4 Receptor Signaling, The Journal of neuroscience : the official journal of the Society for Neuroscience, vol.34, issue.17, pp.5882-94, 2014.
DOI : 10.1523/jneurosci.0410-14.2014
URL : http://www.jneurosci.org/content/34/17/5882.full.pdf
, Chronic intracerebroventricular infusion of insulin reduces food intake and body weight of baboons, Nature, vol.282, issue.5738, pp.503-508, 1979.
DOI : 10.1038/282503a0
, Insulin and the blood-brain barrier, Current pharmaceutical design, vol.9, issue.10, pp.795-800, 2003.
, Relationship between plasma and cerebrospinal fluid insulin levels of dogs, Am J Physiol, vol.233, issue.4, pp.331-335, 1977.
DOI : 10.1152/ajpendo.1977.233.4.e331
, Inflammation in Alzheimer Disease-A Brief Review of the Basic Science and. Cold Spring Harb Perspect Med, pp.1-23, 2012.
, Chemokines / chemokine receptors in the central nervous system and Alzheimer ' s disease, Journal of Neurovirology, pp.32-41, 1998.
, Immunohistochemical study of the beta-chemokine receptors CCR3 and CCR5 and their ligands in normal and Alzheimer's disease brains. The American journal of pathology, vol.153, pp.65542-65545, 1998.
, Metabotropic glutamate receptor activation causes a rapid redistribution of AMPA receptors, Neuropharmacology, issue.6, pp.664-671, 2001.
DOI : 10.1016/s0028-3908(01)00134-4
, Alzheimer's beta-amyloid peptides compete for insulin binding to the insulin receptor, The Journal of neuroscience : the official journal of the Society for Neuroscience, vol.22, issue.10, p.221, 2002.
DOI : 10.1523/jneurosci.22-10-j0001.2002
, Inhibition of Long-Term Potentiation by Interleukin-8 : Implications for Human Dementia, vol.607, pp.600-607, 2002.
DOI : 10.1002/jnr.10503
, CCR3, CCR2A and macrophage inflammatory protein (MIP)-1?, monocyte chemotactic protein-1 (MCP-1) in the mouse hippocampus during and after pilocarpine-induced status epilepticus (PISE), Neuropathology and Applied Neurobiology, vol.35, pp.496-514, 2009.
DOI : 10.1111/j.1365-2990.2009.01022.x
, Mid-and late-life diabetes in relation to the risk of dementia: a population-based twin study, Diabetes, vol.58, issue.1, pp.71-78, 2009.
, PI3K Signaling in the Ventromedial Hypothalamic Nucleus Is Required for Normal Energy Homeostasis, Cell Metabolism, vol.12, issue.1, pp.88-95, 2010.
, Interferon-gamma and tumor necrosis factor-alpha regulate amyloid-beta plaque deposition and beta-secretase expression in Swedish mutant APP transgenic mice. The American journal of pathology, vol.170, pp.680-692, 2007.
DOI : 10.2353/ajpath.2007.060378
URL : http://europepmc.org/articles/pmc1851864?pdf=render
, RAGE and amyloid-beta peptide neurotoxicity in Alzheimer's disease, Nature, vol.382, issue.6593, pp.685-691, 1996.
, PKM zeta maintains late long-term potentiation by N-ethylmaleimidesensitive factor/GluR2-dependent trafficking of postsynaptic AMPA receptors, The Journal of neuroscience : the official journal of the Society for Neuroscience, vol.28, issue.31, pp.7820-7827, 2008.
DOI : 10.1523/jneurosci.0223-08.2008
URL : http://www.jneurosci.org/content/28/31/7820.full.pdf
, Abnormal serine phosphorylation of insulin receptor substrate 1 is associated with tau pathology in Alzheimer's disease and tauopathies, Acta Neuropathologica, vol.128, issue.5, pp.679-689, 2014.
, Increased interleukin-6 expression by microglia from brain of aged mice, Journal of Neuroimmunology, vol.93, issue.1-2, pp.139-148, 1999.
DOI : 10.1016/s0165-5728(98)00217-3
, Immune modulation of learning, memory, neural plasticity and neurogenesis, Brain, Behavior, and Immunity, vol.25, pp.181-213, 2011.
DOI : 10.1016/j.bbi.2010.10.015
, Brain interleukin-1 is involved in spatial memory and passive avoidance conditioning, Neurobiology of learning and memory, vol.78, pp.379-389, 2002.
DOI : 10.1006/nlme.2002.4072
, Synapse Loss and Microglial Activation Precede Tangles in a P301S Tauopathy Mouse Model, Neuron, vol.53, issue.3, pp.337-351, 2007.
DOI : 10.1016/j.neuron.2007.03.022
URL : https://doi.org/10.1016/j.neuron.2007.03.022
, The role of Ab42 in Alzheimer's disease, In Journal of Physiology Paris, pp.289-292, 1998.
, Association analysis of MAPT H1 haplotype and subhaplotypes in Parkinson's disease, Annals of Neurology, vol.62, issue.2, pp.137-144, 2007.
, Hormone replacement therapy and incidence of Alzheimer disease in older women: the Cache County Study, JAMA : the journal of the American Medical Association, vol.288, issue.17, pp.2123-2129, 2002.
, Expression of a Protein Kinase C Inhibitor in Purkinje Cells Blocks Cerebellar LTD and Adaptation of the Vestibulo-Ocular Reflex, Neuron, vol.20, issue.3, pp.495-508, 1998.
, Abeta oligomers cause localized Ca(2+) elevation, missorting of endogenous Tau into dendrites, Tau phosphorylation, and destruction of microtubules and spines, The Journal of neuroscience : the official journal of the Society for Neuroscience, vol.30, issue.36, pp.11938-11950, 2010.
DOI : 10.1523/jneurosci.2357-10.2010
URL : http://www.jneurosci.org/content/jneuro/30/36/11938.full.pdf
, Amyloid-? oligomers induce synaptic damage via Tau-dependent microtubule severing by TTLL6 and spastin, The EMBO journal, vol.32, issue.22, pp.2920-2957, 2013.
DOI : 10.1038/emboj.2013.207
URL : http://emboj.embopress.org/content/32/22/2920.full.pdf
, Tumor-suppressor PTEN affects tau phosphorylation, aggregation, and binding to microtubules, FASEB journal : official publication of the Federation of American Societies for Experimental Biology, vol.20, issue.8, pp.1272-1276, 2006.
DOI : 10.1096/fj.06-5721fje
, The Tyrosine Phosphatase STEP Mediates AMPA Receptor Endocytosis after Metabotropic Glutamate Receptor Stimulation, Journal of Neuroscience, vol.28, issue.42, pp.10561-10566, 2008.
DOI : 10.1523/jneurosci.2666-08.2008
URL : http://www.jneurosci.org/content/28/42/10561.full.pdf
, Chemokine contribution to neuropathic pain : Respective induction of CXCL1 and CXCR2 in spinal cord astrocytes and neurons, Pain, vol.154, issue.10, pp.2185-2197, 2013.
, Insulin-Degrading Enzyme as a Downstream Target of Insulin Receptor Signaling Cascade: Implications for Alzheimer's Disease Intervention, Journal of Neuroscience, vol.24, issue.49, pp.11120-11126, 2004.
, Permissive role of insulin in the expression of long-term potentiation in the hippocampus of immature rats, NeuroSignals, vol.18, pp.236-245, 2011.
, Permissive Role of Insulin in the Expression of Long-Term Potentiation in the Hippocampus of Immature Rats, Neurosignals, vol.18, issue.4, pp.236-245, 2010.
, Insulin and the insulin receptor in experimental models of learning and memory, European Journal of Pharmacology, vol.490, issue.1-3, pp.71-81, 2004.
, Insulin degrading enzyme activity selectively decreases in the hippocampal formation of cases at high risk to develop Alzheimer's disease, Neurobiology of Aging, vol.28, issue.6, pp.824-830, 2007.
, The direction of synaptic plasticity mediated by C-fibers in spinal dorsal horn is decided by Src-family kinases in microglia: The role of tumor necrosis factor-?, Brain, Behavior, and Immunity, vol.24, issue.6, pp.874-880, 2010.
, Extrasynaptic NMDA Receptor in Excitotoxicity: Function Revisited, The Neuroscientist, vol.21, issue.4, pp.337-344, 2015.
DOI : 10.1177/1073858414548724
URL : http://europepmc.org/articles/pmc4620718?pdf=render
, Chemokine CCL2 modulation of neuronal excitability and synaptic transmission in rat hippocampal slices, Journal of Neurochemistry, vol.116, pp.406-414, 2011.
, The roles of amyloid precursor protein (APP) in neurogenesis: Implications to pathogenesis and therapy of Alzheimer disease, Cell adhesion & migration, vol.5, issue.4, pp.280-292, 2011.
, Characterization of the expression of macrophage inflammatory protein-1? (MIP-1?) and C-C chemokine receptor 5 (CCR5) after kainic acid-induced status epilepticus (SE) in juvenile rats, Neuropathology and Applied Neurobiology, vol.38, issue.6, pp.602-616, 2012.
, Who fans the flames of Alzheimer's disease brains? Misfolded tau on the crossroad of neurodegenerative and inflammatory pathways, Journal of Neuroinflammation, vol.9, issue.1, p.47, 2012.
, Chemokines: a new classification system and their role in immunity, Immunity, vol.12, issue.2, pp.121-127, 2000.
, Enduring memory impairment in monkeys after ischemic damage to the hippocampus, The Journal of neuroscience : the official journal of the Society for Neuroscience, vol.12, issue.7, pp.2582-2596, 1992.
DOI : 10.1523/jneurosci.12-07-02582.1992
URL : http://www.jneurosci.org/content/12/7/2582.full.pdf
, Short-term synaptic plasticity, Annual review of neuroscience, vol.12, pp.13-31, 1989.
, Short-term synaptic plasticity. Annual review of physiology, vol.64, pp.355-405, 2002.
, Hippocampus Is Place of Interaction between Unconscious and Conscious Memories, pp.1-19, 2015.
, H Index: 2 ??: 0673440183 @ : elodie.marciniak@gmail.com Research interests: Synaptic function & memory Graduate studies 2012-2015: PhD in Neurosciences, Inserm UMR-S 1172, vol.59800, 1987.
, Insulinoresistance : contribution to pathophysiological development in Alzheimer Disease, Laboratory of Alzheimer & Tauopathies, Inserm UMR-S "Evaluation of the impact of chemokines in the hippocampus 1172 (Director: Dr. Buee, Tutor: Dr. Humez). synaptic activity, 2011.
, Laboratory of Alzheimer & Tauopathies, Evaluation of the synaptic plasticity in a model of Inserm UMR-S 1172 (Director: Dr. Buee, Tutor: Dr. Humez)
,
, Laboratory of Calcium Signal in prostatic and liver "Learning of the technique of patch-clamp and calcium tumors, Director: Dr. Prevarskaya, Tutor: Dr. Mariot). imagery
, Laboratory of Alzheimer & Tauopathies, Inserm "Evaluation of the synaptic plasticity in a model of UMR-S 1172 (Director: Dr. Buee, Tutor: Dr. Humez). myotonic dystrophy" Teaching experiences 2013-2015: Teaching activity, Medical School of Lille: Histology works in 3 rd and 4 th years (64h ETD) 2013-2015: Teaching activity, Medical School of Lille: Histology works in 3 rd and 4 th years
, Biochemistry: Protein extraction, Western Blot, PSD purification, Immunoprecipitation, ELISA, Immunochemistry Animal experimentation: Animal experimentation certification level 2 (Pasteur Institute, Lille, 2013), animal manipulation, physiological monitoring, stereotactic implantation of cannulas, intracerebroventricular injections, intracardiac perfusion, metabolic tasks (ITT, IPGTT) Behavioral experimentations: Y-Maze, Object Recognition, Elevated Plus Maze, Technical qualifications & formations Informatics skills: Word processing software, spreadsheet software (C2I), internet Biostatistics skills: Biostatistical software (Graphpad) Technical skills: Electrophysiology recording: fEPSP recording, 2014.
, The chemokine CCL3 mediates hippocampal synaptic deficits: a potential role in Alzheimer's Disease, The chemokine CCL3 mediates hippocampal synaptic deficits: a potential role in Alzheimer's Disease, 2013.
, Buee, adenosine A2A receptor deletion in a transgenique model of Alzheimer's Disease-like Tau pathology, Purine Club Meeting, 2012.
, The Chemokine MIP-1?/CCL3 impairs mouse hippocampal synaptic transmission, plasticity and Humez, memory, Scientific report, 2015.
,
, protective function of Tau in hippocampal neurons in vivo
,
,
, A2A adenosine receptor deletion is protective in a mouse model of Tauopathy, pp.15-147, 2014.
,
, Myotonic dystrophy CTG expansion A. Munnich, N. Sergeant, G. Gourdon, and M. Gomes-Pereira, affects synaptic vesicle proteins, neurotransmission and mouse behavior, 2013.