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Rôle de la Neutrophil Gelatinase-Associated Lipocalin dans les effets cardiovasculaires et rénaux de l'activation du récepteur minéralocorticoïde. Spécificité et mécanismes d’action

Abstract : Mineralocorticoid receptor (MR) activation by aldosterone plays a major role in cardiovascular remodeling by participating in hypertension, fibrosis and inflammation. Our group has recently evidenced a critical implication of the Neutrophil Gelatinase-Associated Lipocalin (NGAL), a new target of the MR, in the deleterious effects of its activation. In order to better understand the role of NGAL in these effects, we carried out several models of fibrosis in mice presenting a genetic invalidation for NGAL or in mice lacking NGAL in their immune cells specifically. Our results demonstrate that NGAL produced by immune cells plays a pivotal role in MR mediated cardiac and renal damage. Furthermore, our data suggest that inflammatory context could represent a key factor in the pathophysiological implications of NGAL.
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https://tel.archives-ouvertes.fr/tel-01907279
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Submitted on : Monday, October 29, 2018 - 1:02:57 AM
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  • HAL Id : tel-01907279, version 1

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Mathieu Buonafine. Rôle de la Neutrophil Gelatinase-Associated Lipocalin dans les effets cardiovasculaires et rénaux de l'activation du récepteur minéralocorticoïde. Spécificité et mécanismes d’action. Physiologie [q-bio.TO]. Université Pierre et Marie Curie - Paris VI, 2017. Français. ⟨NNT : 2017PA066216⟩. ⟨tel-01907279⟩

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