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Cancer du foie au Cambodge : état des lieux épidémiologiques, description des médecines traditionnelles utilisées et évaluation d'espèces médicinales sélectionnées

Abstract : Liver cancer is the 6th most common and 2nd most lethal cancer in the world. In Cambodia, due to the historical and economic context, there is a lack of accurate data on this pathology. Using epidemiological tools, we described the characteristics of 553 patients with liver cancer at the Calmette Hospital in Phnom Penh, and thus highlighted the importance of infection with hepatitis B and C viruses in the subjects studied. Then we documented the knowledge of 42 of these patients about their disease. We have detailed their therapeutic itineraries, highlighted risky practices (high use of therapeutic injections and dermabrasion techniques) and the use of traditional medicines. We then attempted to understand strategies for the management of patients with liver diseases by traditional healers, and highlighted the variety of remedies used and the importance of Khmer perception of plant properties. Finally, using an in vitro model of liver cancer cell culture coupled with metabolic analysis tools, we evaluated 10 medicinal species, selected on the basis of bibliographic and field criteria, and attempted to identify the compounds potentially responsible for the antiproliferative activity observed.
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François Chassagne. Cancer du foie au Cambodge : état des lieux épidémiologiques, description des médecines traditionnelles utilisées et évaluation d'espèces médicinales sélectionnées. Pharmacologie. Université Paul Sabatier - Toulouse III, 2017. Français. ⟨NNT : 2017TOU30155⟩. ⟨tel-01905694⟩

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