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Méthodes de comparaisons de deux ou plusieurs groupes de données censurées par intervalle. Avec application en immunologie clinique.

Abstract : In the context of analysis of survival data, the comparison of several groups of individuals, where the event of interest is interval censored, represents a methodological challenge. When the monitoring of patients during the study is not continuous, the event of interest may occur between two observation dates; it is said "interval censored". Tests of comparisons of survival time distributions for several groups, adapted for interval censoring, have been developed (score tests, weighted pseudo log-rank tests, rank tests). In this context, we have developped two new group comparison tests adapted to the particular situations of interval censoring. The first test apply to a situation where the alternative hypothesis considers that the hazard functions cross. The second test concerns a situation where the study population has a fraction not at risk for the event of interest. Both of these tests have been applied to real clinical immunology dataset.
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Submitted on : Tuesday, October 23, 2018 - 7:09:06 PM
Last modification on : Friday, October 23, 2020 - 4:58:22 PM
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Sarah Flora Jonas. Méthodes de comparaisons de deux ou plusieurs groupes de données censurées par intervalle. Avec application en immunologie clinique.. Méthodes et statistiques. Université Paris-Saclay, 2018. Français. ⟨NNT : 2018SACLS317⟩. ⟨tel-01902815⟩

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