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Etude de la dynamique des phagocytes mononucléés au cours du processus inflammatoire

Abstract : Contrariwise to the original dogma established by van Furth on the Mononuclear Phagocyte System (MPs), it is now suggested that monocyte fate and functions should not be restricted to macrophage precursors. Experimental evidences show that monocytes can circulate in tissues without differentiating and most of the tissue associated macrophages have embryonic origin. My thesis work focused on migratory activity and effective functions of monocytes and macrophages based on intravital imaging technology. This approach represent a unique tool to study the dynamic of MPs between the vasculature and tissue parenchyma. Our work provided new insights in the role of CX3CR1 in the monocyte deployment during acute inflammatory response.In a model of pulmonary metastases, we also demonstrated that monocytes represent only one part of tumor associated macrophages (TAMs) and the other part is constituted by lung interstitial macrophages. These different subsets of TAMs seem to contribute differently in tumor development and response to chemotherapy.Overall my work provides new insights about monocyte biology beyond their macrophage precursor fate and presents new concepts on the origin of TAMs. It also adds new perspectives in the understanding of biological mechanism regulated by MPs and in the control of the inflammatory response.
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Submitted on : Thursday, October 18, 2018 - 1:01:41 AM
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  • HAL Id : tel-01898078, version 1


Pauline Hamon. Etude de la dynamique des phagocytes mononucléés au cours du processus inflammatoire. Immunologie. Université Pierre et Marie Curie - Paris VI, 2017. Français. ⟨NNT : 2017PA066435⟩. ⟨tel-01898078⟩



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