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Estimation de l’incidence de l’infection par le VIH en France à l’aide d’un test biologique d’infection récente

Abstract : Knowledge of HIV incidence is essential to provide a timely picture of the HIV epidemie, in arder to target and evaluate prevention efforts. However, current methods of HIV incidence estimation can hardly provide data on current transmission patterns. A new approach based on biological procedures that discriminate recent from long-standing HIV infection has been developed since the mid 1990s. Its major advantage is that it can provide incidence estimates from a single population sample without the need for a longitudinal follow-up. The French national HIV/AIDS case reporting system has included aroutine testing for recent infection since its debut in 2003. The objective of this PhD thesis is to estimate population-based HIV incidence in France by using HIV case reporting data and results from recent infection testing. Its first part is a review of laboratory-based methods for HIV incidence estimation. The second part is dedicated to the calibration of the test for recent infection used in France using a reference sample of population. The third partis giving estimates of population-based HIV incidence in France. Based on this new method applied at a national scale, HIV incidence will be tracked over time in arder to monitor the HIV transmission dynamics in the various risk groups of the population and to better target prevention.
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Stéphane Le Vu. Estimation de l’incidence de l’infection par le VIH en France à l’aide d’un test biologique d’infection récente. Santé publique et épidémiologie. Université Paris-Sud XI, 2010. Français. ⟨tel-01892252⟩

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