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Theses

Elaboration de nanoparticules à  luminescence persistante pour l'imagerie optique dans le domaine du visible et du proche infrarouge

Abstract : This thesis aims to develop persistent luminescent nanoparticles (NPs) for optical imaging in the deep red and near infrared range. Their use has a clear advantage as the irradiation step can be performed before injection, avoiding tissue stress and other autofluorescence phenomena. The chemical compositions studied are also re-excitable in vivo. We propose an original way of synthesis for the elaboration of “small” ZnGa2O4:Cr3+ NPs. Hydrothermal synthesis assisted by microwave heating followed by a heat treatment is used to obtain the NPs. The extensive characterization of the persistent luminescence properties and of the material’s fine structure showed a direct correlation between luminescence and local cation order in the structure (distribution and distortion of cationic sites). Thus, we have shown the benefits of a heat treatment without sintering on the improvement of luminescence properties. We have also highlighted the enhancement provided by the addition of a codopant such as Bi3+ ions or the modification of the matrix by substituting a part of Ga3+ ions by Ge4+ ions. The optimization limits of this material being reached, doping the matrix with Ni2+ ions to move the persistent luminescence in the near infrared range, opens a new pathway in this research field. Exploiting this new window for optical imaging should allow imaging deeper into tissue with a better signal-to-noise ratio.
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Morgane Pellerin. Elaboration de nanoparticules à  luminescence persistante pour l'imagerie optique dans le domaine du visible et du proche infrarouge. Matériaux. Université Pierre et Marie Curie - Paris VI, 2017. Français. ⟨NNT : 2017PA066537⟩. ⟨tel-01891219⟩

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