A. P. Abdala, J. M. Bissonnette, and A. Newman-tancredi, Pinpointing brainstem mechanisms responsible for autonomic dysfunction in Rett syndrome: therapeutic perspectives for 5-HT1A agonists, Front Physiol, vol.5, p.205, 2014.

A. P. Abdala, M. Dutschmann, J. M. Bissonnette, and J. F. Paton, Correction of respiratory disorders in a mouse model of Rett syndrome, Proc Natl Acad Sci U S A, vol.107, pp.18208-18213, 2010.

A. Adell, P. Celada, M. T. Abellan, and F. Artigas, Origin and functional role of the extracellular serotonin in the midbrain raphe nuclei, Brain Res Brain Res Rev, vol.39, pp.154-180, 2002.

Y. Ago, Y. Koyama, A. Baba, and T. Matsuda, Regulation by 5-HT1A receptors of the in vivo release of 5-HT and DA in mouse frontal cortex, Neuropharmacology, vol.45, pp.1050-1056, 2003.

E. Akimova, R. Lanzenberger, and S. Kasper, The serotonin-1A receptor in anxiety disorders, Biol Psychiatry, vol.66, pp.627-635, 2009.

I. Alafuzoff, T. Arzberger, S. Al-sarraj, I. Bodi, N. Bogdanovic et al., Staging of neurofibrillary pathology in Alzheimer's disease: a study of the BrainNet Europe Consortium, Brain Pathol, vol.18, pp.484-496, 2008.

P. R. Albert and S. Lemonde, 5-HT1A receptors, gene repression, and depression: guilt by association, Neuroscientist, vol.10, pp.575-593, 2004.

P. R. Albert, F. Vahid-ansari, and C. Luckhart, Serotonin-prefrontal cortical circuitry in anxiety and depression phenotypes: pivotal role of pre-and post-synaptic 5-HT1A receptor expression, Front Behav Neurosci, vol.8, 0199.

S. P. Alexander, H. E. Benson, E. Faccenda, A. J. Pawson, J. L. Sharman et al., The Concise Guide to PHARMACOLOGY 2013/14: G proteincoupled receptors, Br J Pharmacol, vol.170, pp.1459-1581, 2013.

S. C. Altieri, A. L. Garcia-garcia, E. D. Leonardo, and A. M. Andrews, Rethinking 5-HT1A receptors: emerging modes of inhibitory feedback of relevance to emotion-related behavior, ACS Chem Neurosci, vol.4, pp.72-83, 2013.

B. Amilhon, E. Lepicard, T. Renoir, R. Mongeau, D. Popa et al., VGLUT3 (vesicular glutamate transporter type 3) contribution to the regulation of serotonergic transmission and anxiety, J Neurosci, vol.30, pp.2198-2210, 2010.

I. M. Anderson, S. Mckie, R. Elliott, S. R. Williams, and J. F. Deakin, Assessing human 5-HT function in vivo with pharmacoMRI, Neuropharmacology, vol.55, pp.1029-1037, 2008.

R. Andrade and S. Haj-dahmane, Serotonin neuron diversity in the dorsal raphe, ACS Chem Neurosci, vol.4, pp.22-25, 2013.

R. Andrade, D. Huereca, J. G. Lyons, E. M. Andrade, and K. M. Mcgregor, 5-HT1A ReceptorMediated Autoinhibition and the Control of Serotonergic Cell Firing, ACS Chem Neurosci, vol.6, pp.1110-1115, 2015.

B. Andree, C. Halldin, V. W. Pike, R. N. Gunn, H. Olsson et al., The PET radioligand [carbonyl-(11)C]desmethyl-WAY-100635 binds to 5-HT(1A) receptors and provides a higher radioactive signal than [carbonyl-(11)C]WAY-100635 in the human brain, J Nucl Med, vol.43, pp.292-303, 2002.

J. Arnt and C. K. Olsen, 5-HT6 receptor ligands and their antipsychotic potential, Int Rev Neurobiol, vol.96, pp.141-161, 2011.

O. J. Arthurs and S. Boniface, How well do we understand the neural origins of the fMRI BOLD signal?, Trends Neurosci, vol.25, pp.27-31, 2002.

M. B. Assie, L. Bardin, A. L. Auclair, E. Carilla-durand, R. Depoortere et al., F15599, a highly selective post-synaptic 5HT(1A) receptor agonist: in-vivo profile in behavioural models of antidepressant and serotonergic activity, Int J Neuropsychopharmacol, vol.13, pp.1285-1298, 2010.

M. B. Assie, C. Cosi, and W. Koek, Correlation between low/high affinity ratios for 5-HT(1A) receptors and intrinsic activity, Eur J Pharmacol, vol.386, pp.97-103, 1999.

M. B. Assie, H. Lomenech, V. Ravailhe, V. Faucillon, and A. Newman-tancredi, Rapid desensitization of somatodendritic 5-HT1A receptors by chronic administration of the high-efficacy 5HT1A agonist, F13714: a microdialysis study in the rat, Br J Pharmacol, vol.149, pp.170-178, 2006.

M. B. Assie, V. Ravailhe, V. Faucillon, and A. Newman-tancredi, Contrasting contribution of 5hydroxytryptamine 1A receptor activation to neurochemical profile of novel antipsychotics: frontocortical dopamine and hippocampal serotonin release in rat brain, J Pharmacol Exp Ther, vol.315, pp.265-272, 2005.

S. Avissar and G. Schreiber, The involvement of G proteins and regulators of receptor-G protein coupling in the pathophysiology, diagnosis and treatment of mood disorders, Clin Chim Acta, vol.366, pp.37-47, 2006.

E. C. Azmitia, P. J. Gannon, N. M. Kheck, and P. M. Whitaker-azmitia, Cellular localization of the 5-HT1A receptor in primate brain neurons and glial cells, Neuropsychopharmacology, vol.14, pp.35-46, 1996.

N. Aznavour, L. Rbah, L. Leger, C. Buda, J. P. Sastre et al., A comparison of in vivo and in vitro neuroimaging of 5-HT 1A receptor binding sites in the cat brain, J Chem Neuroanat, vol.31, pp.226-232, 2006.

N. Aznavour, L. Rbah, M. Riad, A. Reilhac, N. Costes et al., A PET imaging study of 5-HT(1A) receptors in cat brain after acute and chronic fluoxetine treatment, Neuroimage, vol.33, pp.834-842, 2006.

N. Aznavour and L. Zimmer, 18F]MPPF as a tool for the in vivo imaging of 5-HT1A receptors in animal and human brain, Neuropharmacology, vol.52, pp.695-707, 2007.

K. G. Baker, G. M. Halliday, J. P. Hornung, L. B. Geffen, R. G. Cotton et al., Distribution, morphology and number of monoamine-synthesizing and substance P-containing neurons in the human dorsal raphe nucleus, Neuroscience, vol.42, pp.757-775, 1991.

K. G. Baker, G. M. Halliday, and I. Tork, Cytoarchitecture of the human dorsal raphe nucleus, J Comp Neurol, vol.301, pp.147-161, 1990.

A. Bakker, G. L. Krauss, M. S. Albert, C. L. Speck, L. R. Jones et al., Reduction of hippocampal hyperactivity improves cognition in amnestic mild cognitive impairment, Neuron, vol.74, pp.467-474, 2012.

B. Ballanger, H. Klinger, J. Eche, J. Lerond, A. E. Vallet et al., Role of serotonergic 1A receptor dysfunction in depression associated with Parkinson's disease, Mov Disord, vol.27, pp.84-89, 2012.

R. A. Bantick, A. J. Montgomery, C. J. Bench, T. Choudhry, N. Malek et al., A positron emission tomography study of the 5-HT1A receptor in schizophrenia and during clozapine treatment, J Psychopharmacol, vol.18, pp.346-354, 2004.

R. A. Bantick, E. A. Rabiner, E. Hirani, M. H. De-vries, S. P. Hume et al., Occupancy of agonist drugs at the 5-HT1A receptor, Neuropsychopharmacology, vol.29, pp.847-859, 2004.

L. Bardin, M. B. Assie, M. Pelissou, I. Royer-urios, A. Newman-tancredi et al., methylpyridin-2-ylmethyl)-amino]-me thyl}piperidin-1-yl]methanone, fumaric acid salt]: relationship with 5HT1A receptor occupancy and kinetic parameters, J Pharmacol Exp Ther, vol.312, issue.5, pp.1034-1042, 2005.

L. Bardin, J. P. Tarayre, N. Malfetes, W. Koek, and F. C. Colpaert, Profound, non-opioid analgesia produced by the high-efficacy 5-HT(1A) agonist F 13640 in the formalin model of tonic nociceptive pain, Pharmacology, vol.67, pp.182-194, 2003.

N. M. Barnes and T. Sharp, A review of central 5-HT receptors and their function, Neuropharmacology, vol.38, pp.1083-1152, 1999.

K. E. Barrett, S. M. Barman, S. Boitano, and H. Brooks, Ganong's Review of Medical Physiology, 2012.

H. G. Baumgarten and L. Lachenmayer, 7-dihydroxytryptamine: improvement in chemical lesioning of indoleamine neurons in the mammalian brain, Z Zellforsch Mikrosk Anat, vol.5, pp.399-414, 1972.

S. A. Bayer, Hippocampal region, The Rat Nervous System, vol.1, pp.335-352, 1985.

D. A. Bayliss, Y. W. Li, and E. M. Talley, Effects of serotonin on caudal raphe neurons: activation of an inwardly rectifying potassium conductance, J Neurophysiol, vol.77, pp.1349-1361, 1997.

S. G. Beck, K. C. Choi, and T. J. List, Comparison of 5-hydroxytryptamine1A-mediated hyperpolarization in CA1 and CA3 hippocampal pyramidal cells, J Pharmacol Exp Ther, vol.263, pp.350-359, 1992.

G. Becker, R. Bolbos, N. Costes, J. Redoute, A. Newman-tancredi et al., Selective serotonin 5-HT1A receptor biased agonists elicitdistinct brain activation patterns: a pharmacoMRI study, Sci Rep, vol.6, p.26633, 2016.

G. Becker, N. Streichenberger, T. Billard, A. Newman-tancredi, and L. Zimmer, A postmortem study to compare agonist and antagonist 5-HT1A receptor-binding sites in Alzheimer's disease, CNS Neurosci Ther, vol.20, pp.930-934, 2014.

B. Benhamu, M. Martin-fontecha, H. Vazquez-villa, L. Pardo, and M. L. Lopez-rodriguez, Serotonin 5-HT6 receptor antagonists for the treatment of cognitive deficiency in Alzheimer's disease, J Med Chem, vol.57, pp.7160-7181, 2014.

K. A. Berg and W. P. Clarke, Development of functionally selective agonists as novel therapeutic agents, Drug Discovery Today : Therapeutic Strategies, vol.3, pp.421-428, 2006.

M. Berger, J. A. Gray, and B. L. Roth, The expanded biology of serotonin, Annu Rev Med, vol.60, pp.355-366, 2009.

T. Billard, D. Le-bars, and L. Zimmer, PET radiotracers for molecular imaging of serotonin 5-HT1A receptors, Curr Med Chem, vol.21, pp.70-81, 2014.
URL : https://hal.archives-ouvertes.fr/hal-00947714

R. M. Birn, K. Murphy, D. A. Handwerker, and P. A. Bandettini, fMRI in the presence of taskcorrelated breathing variations, Neuroimage, vol.47, pp.1092-1104, 2009.

C. Bishop, D. M. Krolewski, K. L. Eskow, C. J. Barnum, K. B. Dupre et al., Contribution of the striatum to the effects of 5-HT1A receptor stimulation in L-DOPA-treated hemiparkinsonian rats, J Neurosci Res, vol.87, pp.1645-1658, 2009.

A. Bjorklund, H. G. Baumgarten, and A. Rensch, 7-Dihydroxytryptamine: improvement of its selectivity for serotonin neurons in the CNS by pretreatment with desipramine, J Neurochem, vol.5, pp.833-835, 1975.

M. C. Boadle-biber, Regulation of serotonin synthesis, Prog Biophys Mol Biol, vol.60, pp.1-15, 1993.

J. Bockaert, S. Claeysen, V. Compan, and A. Dumuis, 5-HT(4) receptors: history, molecular pharmacology and brain functions, Neuropharmacology, vol.55, pp.922-931, 2008.
URL : https://hal.archives-ouvertes.fr/hal-01667629

K. Boekhoorn, M. Joels, and P. J. Lucassen, Increased proliferation reflects glial and vascularassociated changes, but not neurogenesis in the presenile Alzheimer hippocampus, Neurobiol Dis, vol.24, pp.1-14, 2006.

K. Bohmaker, F. Bordi, and E. Meller, The effects of pertussis toxin on dopamine D2 and serotonin 5-HT1A autoreceptor-mediated inhibition of neurotransmitter synthesis: relationship to receptor reserve, Neuropharmacology, vol.31, pp.451-459, 1992.

G. Bonanno, A. Fassio, P. Severi, A. Ruelle, and M. Raiteri, Fenfluramine releases serotonin from human brain nerve endings by a dual mechanism, J Neurochem, vol.63, pp.1163-1166, 1994.

J. Borg, Molecular imaging of the 5-HT(1A) receptor in relation to human cognition, Behav Brain Res, vol.195, pp.103-111, 2008.

F. Borsini, K. Evans, K. Jason, F. Rohde, B. Alexander et al., Pharmacology of flibanserin, CNS Drug Rev, vol.8, pp.117-142, 2002.

A. Bortolozzi, M. Masana, L. Diaz-mataix, R. Cortes, M. C. Scorza et al., Dopamine release induced by atypical antipsychotics in prefrontal cortex requires 5-HT(1A) receptors but not 5-HT(2A) receptors, Int J Neuropsychopharmacol, vol.13, pp.1299-1314, 2010.

D. M. Bowen, A. Najlerahim, A. W. Procter, P. T. Francis, and E. Murphy, Circumscribed changes of the cerebral cortex in neuropsychiatric disorders of later life, Proc Natl Acad Sci U S A, vol.86, pp.9504-9508, 1989.

H. Braak and E. Braak, Neuropathological stageing of Alzheimer-related changes, Acta Neuropathol, vol.82, pp.239-259, 1991.

J. Buritova, G. Berrichon, C. Cathala, F. Colpaert, and D. Cussac, Region-specific changes in 5HT1A agonist-induced Extracellular signal-Regulated Kinases 1/2 phosphorylation in rat brain: a quantitative ELISA study, Neuropharmacology, vol.56, pp.350-361, 2009.

J. Buritova, S. Larrue, M. Aliaga, J. M. Besson, and F. Colpaert, Effects of the high-efficacy 5-HT1A receptor agonist, F 13640 in the formalin pain model: a c-Fos study, Eur J Pharmacol, vol.514, pp.121-130, 2005.

J. Buritova, J. P. Tarayre, J. M. Besson, and F. Colpaert, The novel analgesic and high-efficacy 5HT1A receptor agonist, F 13640 induces c-Fos protein expression in spinal cord dorsal horn neurons, Brain Res, vol.974, pp.212-221, 2003.

P. W. Burnet, S. L. Eastwood, and P. J. Harrison, 5-HT1A and 5-HT2A receptor mRNAs and binding site densities are differentially altered in schizophrenia, Neuropsychopharmacology, vol.15, pp.442-455, 1996.

P. W. Burnet, S. L. Eastwood, and P. J. Harrison, 3H]WAY-100635 for 5-HT1A receptor autoradiography in human brain: a comparison with [3H]8-OH-DPAT and demonstration of increased binding in the frontal cortex in schizophrenia, Neurochem Int, vol.30, pp.565-574, 1997.

P. W. Burnet, S. L. Eastwood, K. Lacey, and P. J. Harrison, The distribution of 5-HT1A and 5-HT2A receptor mRNA in human brain, Brain Res, vol.676, pp.157-168, 1995.

R. B. Buxton, The physics of functional magnetic resonance imaging (fMRI), Rep Prog Phys, vol.76, p.96601, 2013.

R. Canese, E. M. Marco, F. De-pasquale, F. Podo, G. Laviola et al., Differential response to specific 5-Ht(7) versus whole-serotonergic drugs in rat forebrains: a phMRI study, Neuroimage, vol.58, pp.885-894, 2011.

A. Carlsson, B. Falck, and N. A. Hillarp, Cellular localization of brain monoamines, Acta Physiol Scand Suppl, vol.56, pp.1-28, 1962.

R. E. Carson, PET physiological measurements using constant infusion, Nucl Med Biol, vol.27, pp.657-660, 2000.

R. Casanova, R. Srikanth, A. Baer, P. J. Laurienti, J. H. Burdette et al., Biological parametric mapping: A statistical toolbox for multimodality brain image analysis, Neuroimage, vol.34, pp.137-143, 2007.

J. M. Casanovas, O. Berton, P. Celada, and F. Artigas, In vivo actions of the selective 5-HT1A receptor agonist BAY x 3702 on serotonergic cell firing and release, Naunyn Schmiedebergs Arch Pharmacol, vol.362, pp.248-254, 2000.

Y. Chaput, P. Blier, and C. De-montigny, In vivo electrophysiological evidence for the regulatory role of autoreceptors on serotonergic terminals, J Neurosci, vol.6, pp.2796-2801, 1986.

Y. Charnay, L. Leger, P. G. Vallet, B. Greggio, P. R. Hof et al., Mapping of 5-HT1a receptor binding sites in the feline brain : A quantitative autoradiographic study using, Biogenic Amines, vol.13, pp.217-232, 1997.

Y. Charnay and L. Leger, Brain serotonergic circuitries, Dialogues Clin Neurosci, vol.12, pp.471-487, 2010.

B. R. Chemel, B. L. Roth, B. Armbruster, V. J. Watts, and D. E. Nichols, WAY-100635 is a potent dopamine D4 receptor agonist, Psychopharmacology (Berl), vol.188, pp.244-251, 2006.

Y. C. Chen, W. R. Galpern, A. L. Brownell, R. T. Matthews, M. Bogdanov et al., Detection of dopaminergic neurotransmitter activity using pharmacologic MRI: correlation with PET, microdialysis, and behavioral data, Magn Reson Med, vol.38, pp.389-398, 1997.

L. L. Cheng, S. J. Wang, and P. W. Gean, Serotonin depresses excitatory synaptic transmission and depolarization-evoked Ca2+ influx in rat basolateral amygdala via 5-HT1A receptors, Eur J Neurosci, vol.10, pp.2163-2172, 1998.

Z. Chilmonczyk, A. J. Bojarski, A. Pilc, and I. Sylte, Functional Selectivity and Antidepressant Activity of Serotonin 1A Receptor Ligands, Int J Mol Sci, vol.16, pp.18474-18506, 2015.

B. T. Christian, D. W. Wooten, A. T. Hillmer, D. L. Tudorascu, A. K. Converse et al., Serotonin transporter genotype affects serotonin 5-HT1A binding in primates, J Neurosci, vol.33, pp.2512-2516, 2013.

W. P. Clarke, F. D. Yocca, and S. Maayani, Lack of 5-hydroxytryptamine1A-mediated inhibition of adenylyl cyclase in dorsal raphe of male and female rats, J Pharmacol Exp Ther, vol.277, pp.1259-1266, 1996.

E. F. Coccaro and R. Lee, Cerebrospinal fluid 5-hydroxyindolacetic acid and homovanillic acid: reciprocal relationships with impulsive aggression in human subjects, J Neural Transm, vol.117, pp.241-248, 2010.

F. C. Colpaert, K. Deseure, L. Stinus, and H. Adriaensen, High-efficacy 5-hydroxytryptamine 1A receptor activation counteracts opioid hyperallodynia and affective conditioning, J Pharmacol Exp Ther, vol.316, pp.892-899, 2006.

F. C. Colpaert, J. P. Tarayre, W. Koek, P. J. Pauwels, L. Bardin et al., Large-amplitude 5-HT1A receptor activation: a new mechanism of profound, central analgesia, Neuropharmacology, vol.43, pp.945-958, 2002.

D. M. Cooper and C. Londos, GTP-dependent stimulation and inhibition of adenylate cyclase, Horiz Biochem Biophys, vol.6, pp.309-333, 1982.

A. E. Corcoran, M. R. Hodges, Y. Wu, W. Wang, C. J. Wylie et al., Medullary serotonin neurons and central CO2 chemoreception, Respir Physiol Neurobiol, vol.168, pp.49-58, 2009.

N. Costes, I. Merlet, K. Ostrowsky, I. Faillenot, F. Lavenne et al., A 18F-MPPF PET normative database of 5-HT1A receptor binding in men and women over aging, J Nucl Med, vol.46, 1980.

N. Costes, L. Zimmer, A. Reilhac, F. Lavenne, P. Ryvlin et al., Test-retest reproducibility of 18F-MPPF PET in healthy humans: a reliability study, J Nucl Med, vol.48, pp.1279-1288, 2007.

A. J. Cross, P. Slater, E. K. Perry, and R. H. Perry, An autoradiographic analysis of serotonin receptors in human temporal cortex: Changes in Alzheimer-type dementia, Neurochem Int, vol.13, pp.89-96, 1988.

A. Dahlstrom and K. Fuxe, Localization of monoamines in the lower brain stem, Experientia, vol.20, pp.398-399, 1964.

B. Darocha-souto, T. C. Scotton, M. Coma, A. Serrano-pozo, T. Hashimoto et al., Brain oligomeric beta-amyloid but not total amyloid plaque burden correlates with neuronal loss and astrocyte inflammatory response in amyloid precursor protein/tau transgenic mice, J Neuropathol Exp Neurol, vol.70, pp.360-376, 2011.

S. F. De-boer and A. Newman-tancredi, Anti-aggressive effects of the selective high-efficacy 'biased' 5-HT(1)A receptor agonists F15599 and F13714 in male WTG rats, Psychopharmacology (Berl), vol.233, pp.937-947, 2016.

E. H. De-figueiredo, A. F. Borgonovi, and T. M. Doring, Basic concepts of MR imaging, diffusion MR imaging, and diffusion tensor imaging, Magn Reson Imaging Clin N Am, vol.19, pp.1-22, 2011.

R. De-flores, R. La-joie, and G. Chetelat, Structural imaging of hippocampal subfields in healthy aging and Alzheimer's disease, Neuroscience, vol.309, pp.29-50, 2015.

M. De-vivo and S. Maayani, Characterization of the 5-hydroxytryptamine1a receptor-mediated inhibition of forskolin-stimulated adenylate cyclase activity in guinea pig and rat hippocampal membranes, J Pharmacol Exp Ther, vol.238, pp.248-253, 1986.

S. T. Dekosky, M. D. Ikonomovic, S. D. Styren, L. Beckett, S. Wisniewski et al., Upregulation of choline acetyltransferase activity in hippocampus and frontal cortex of elderly subjects with mild cognitive impairment, Ann Neurol, vol.51, pp.145-155, 2002.

S. Deleye, J. Verhaeghe, L. Wyffels, S. Dedeurwaerdere, S. Stroobants et al., Towards a reproducible protocol for repetitive and semi-quantitative rat brain imaging with (18) F-FDG: exemplified in a memantine pharmacological challenge, Neuroimage, vol.96, pp.276-287, 2014.

G. Demarquay, A. Lothe, J. P. Royet, N. Costes, G. Mick et al., Brainstem changes in 5-HT1A receptor availability during migraine attack, Cephalalgia, vol.31, pp.84-94, 2011.

R. Depoortere, A. L. Auclair, L. Bardin, F. C. Colpaert, B. Vacher et al., F15599, a preferential post-synaptic 5-HT1A receptor agonist: activity in models of cognition in comparison with reference 5-HT1A receptor agonists, Eur Neuropsychopharmacol, vol.20, pp.641-654, 2010.

V. Derkach, A. Surprenant, and R. A. North, 5-HT3 receptors are membrane ion channels, Nature, vol.339, pp.706-709, 1989.

L. Descarries and N. Mechawar, Ultrastructural evidence for diffuse transmission by monoamine and acetylcholine neurons of the central nervous system, Prog Brain Res, vol.125, pp.27-47, 2000.

L. Descarries and M. Riad, Effects of the antidepressant fluoxetine on the subcellular localization of 5-HT1A receptors and SERT, Philos Trans R Soc Lond B Biol Sci, vol.367, pp.2416-2425, 2012.

K. Deseure, W. Koek, H. Adriaensen, and F. C. Colpaert, methyl-pyridin-2-ylmethyl)-amino]-methyl]piperidin-1-yl]-methadone (F 13640) attenuates allodynia-like behavior in a rat model of trigeminal neuropathic pain, J Pharmacol Exp Ther, vol.306, issue.5, pp.505-514, 2003.

J. A. Detre, H. Rao, D. J. Wang, Y. F. Chen, and Z. Wang, Applications of arterial spin labeled MRI in the brain, J Magn Reson Imaging, vol.35, pp.1026-1037, 2012.

D. Chiara, G. Valentini, V. Fenu, and S. , Behavioral and neurochemical pharmacology of 5-HT6 receptors related to reward and reinforcement, Int Rev Neurobiol, vol.96, pp.111-139, 2011.

L. Diaz-mataix, F. Artigas, and P. Celada, Activation of pyramidal cells in rat medial prefrontal cortex projecting to ventral tegmental area by a 5-HT1A receptor agonist, Eur Neuropsychopharmacol, vol.16, pp.288-296, 2006.

L. Diaz-mataix, M. C. Scorza, A. Bortolozzi, M. Toth, P. Celada et al., Involvement of 5HT1A receptors in prefrontal cortex in the modulation of dopaminergic activity: role in atypical antipsychotic action, J Neurosci, vol.25, pp.10831-10843, 2005.

B. C. Dickerson, D. H. Salat, J. F. Bates, M. Atiya, R. J. Killiany et al., Medial temporal lobe function and structure in mild cognitive impairment, Ann Neurol, vol.56, pp.27-35, 2004.

B. C. Dickerson, D. H. Salat, D. N. Greve, E. F. Chua, E. Rand-giovannetti et al., Increased hippocampal activation in mild cognitive impairment compared to normal aging and AD, Neurology, vol.65, pp.404-411, 2005.

M. H. Donovan, U. Yazdani, R. D. Norris, D. Games, D. C. German et al., Decreased adult hippocampal neurogenesis in the PDAPP mouse model of Alzheimer's disease, J Comp Neurol, vol.495, pp.70-83, 2006.

W. C. Drevets, M. E. Thase, E. L. Moses-kolko, J. Price, E. Frank et al., Serotonin-1A receptor imaging in recurrent depression: replication and literature review, Nucl Med Biol, vol.34, pp.865-877, 2007.

B. Dubois, H. H. Feldman, C. Jacova, S. T. Dekosky, P. Barberger-gateau et al., Research criteria for the diagnosis of Alzheimer's disease: revising the NINCDS-ADRDA criteria, Lancet Neurol, vol.6, pp.734-746, 2007.

J. R. Duncan, D. S. Paterson, J. M. Hoffman, D. J. Mokler, N. S. Borenstein et al., Brainstem serotonergic deficiency in sudden infant death syndrome, JAMA, vol.303, pp.430-437, 2010.

K. B. Dupre, K. L. Eskow, C. J. Barnum, and C. Bishop, Striatal 5-HT1A receptor stimulation reduces D1 receptor-induced dyskinesia and improves movement in the hemiparkinsonian rat, Neuropharmacology, vol.55, pp.1321-1328, 2008.

M. Dutschmann, H. Waki, T. Manzke, A. E. Simms, A. E. Pickering et al., The potency of different serotonergic agonists in counteracting opioid evoked cardiorespiratory disturbances, Philos Trans R Soc Lond B Biol Sci, vol.364, pp.2611-2623, 2009.

H. M. Duvernoy, F. Cattin, G. Fatterpekar, T. Naidich, C. Raybaud et al., The Human Hippocampus, 2005.

A. Egerton, M. A. Mehta, A. J. Montgomery, J. M. Lappin, O. D. Howes et al., The dopaminergic basis of human behaviors: A review of molecular imaging studies, Neurosci Biobehav Rev, vol.33, pp.1109-1132, 2009.

S. El-mestikawy, M. Riad, A. M. Laporte, D. Verge, G. Daval et al., Production of specific anti-rat 5-HT1A receptor antibodies in rabbits injected with a synthetic peptide, Neurosci Lett, vol.118, pp.189-192, 1990.

A. S. Elhwuegi, Central monoamines and their role in major depression, Prog Neuropsychopharmacol Biol Psychiatry, vol.28, pp.435-451, 2004.

V. Erspamer and M. Vialli, Ricerche sul secreto delle cellule enterocromaffini, Boll Soc Med-chir Pavia, vol.51, pp.357-363, 1937.

V. Erspamer and B. Asero, Identification of enteramine, the specific hormone of the enterochromaffin cell system, as 5-hydroxytryptamine, Nature, vol.169, pp.800-801, 1952.

A. Ettrup, C. Svarer, B. Mcmahon, S. Da-cunha-bang, S. Lehel et al., Serotonin 2A receptor agonist binding in the human brain with, )C]Cimbi-36: Test-retest reproducibility, vol.130, pp.167-174, 2016.

G. Fabbrini, J. M. Brotchie, F. Grandas, M. Nomoto, and C. G. Goetz, Levodopa-induced dyskinesias, Mov Disord, vol.22, pp.1379-1389, 2007.

A. Fargin, J. R. Raymond, M. J. Lohse, B. K. Kobilka, M. G. Caron et al., The genomic clone G-21 which resembles a beta-adrenergic receptor sequence encodes the 5-HT1A receptor, Nature, vol.335, pp.358-360, 1988.

J. D. Fernstrom, Effects on the diet on brain neurotransmitters, Metabolism, vol.26, pp.207-223, 1977.

M. Filip and M. Bader, Overview on 5-HT receptors and their role in physiology and pathology of the central nervous system, Pharmacol Rep, vol.61, pp.761-777, 2009.

S. J. Finnema, M. Scheinin, M. Shahid, J. Lehto, E. Borroni et al., Application of cross-species PET imaging to assess neurotransmitter release in brain, Psychopharmacology (Berl), vol.232, pp.4129-4157, 2015.

P. T. Francis, M. N. Pangalos, R. C. Pearson, D. N. Middlemiss, G. C. Stratmann et al., 5Hydroxytryptamine1A but not 5-hydroxytryptamine2 receptors are enriched on neocortical pyramidal neurones destroyed by intrastriatal volkensin, J Pharmacol Exp Ther, vol.261, pp.1273-1281, 1992.

T. Freret, V. Lelong-boulouard, P. Lecouflet, K. Hamidouche, F. Dauphin et al., Comodulation of an allosteric modulator of nicotinic receptor-cholinesterase inhibitor (galantamine) and a 5-HT4 receptor agonist (RS-67333): effect on scopolamine-induced memory deficit in the mouse, Psychopharmacology, vol.234, pp.2365-2374, 2017.
URL : https://hal.archives-ouvertes.fr/hal-02135214

M. Fujio, S. Nagata, K. Kawamura, N. Sugiyama, H. Tanaka et al., Synthesis and evaluation of (11)C-labeled (S)-N-[[1-(2-phenylethyl) pyrrolidin-2-yl]methyl]-3methylthiobenzamide as a PET 5-HT(1A) receptor ligand, Nucl Med Biol, vol.29, pp.657-663, 2002.

J. H. Gaddum and Z. P. Picarelli, Two kinds of tryptamine receptor, Br J Pharmacol Chemother, vol.12, pp.323-328, 1957.

M. Ganz, L. Feng, H. D. Hansen, V. Beliveau, C. Svarer et al., Cerebellar heterogeneity and its impact on PET data quantification of 5-HT receptor radioligands, J Cereb Blood Flow Metab, pp.271678-16686092, 2017.

A. Garcia-jimenez, R. F. Cowburn, T. G. Ohm, H. Lasn, B. Winblad et al., Loss of stimulatory effect of guanosine triphosphate on [(35)S]GTPgammaS binding correlates with Alzheimer's disease neurofibrillary pathology in entorhinal cortex and CA1 hippocampal subfield, J Neurosci Res, vol.67, pp.388-398, 2002.

M. N. Garnovskaya, T. Van-biesen, B. Hawe, S. Casanas-ramos, R. J. Lefkowitz et al., Ras-dependent activation of fibroblast mitogen-activated protein kinase by 5-HT1A receptor via a G protein beta gamma-subunit-initiated pathway, Biochemistry, vol.35, pp.13716-13722, 1996.

P. Gaspar and C. Lillesaar, Probing the diversity of serotonin neurons, Philos Trans R Soc Lond B Biol Sci, vol.367, pp.2382-2394, 2012.

M. D. Gershon and J. Tack, The serotonin signaling system: from basic understanding to drug development for functional GI disorders, Gastroenterology, vol.132, pp.397-414, 2007.

T. W. Gettys, T. A. Fields, and J. R. Raymond, Selective activation of inhibitory G-protein alphasubunits by partial agonists of the human 5-HT1A receptor, Biochemistry, vol.33, pp.4283-4290, 1994.

P. Ghanouni, Z. Gryczynski, J. J. Steenhuis, T. W. Lee, D. L. Farrens et al., Functionally different agonists induce distinct conformations in the G protein coupling domain of the beta 2 adrenergic receptor, J Biol Chem, vol.276, pp.24433-24436, 2001.

P. Giannoni, F. Gaven, D. De-bundel, K. Baranger, E. Marchetti-gauthier et al., Early administration of RS 67333, a specific 5HT4 receptor agonist, prevents amyloidogenesis and behavioral deficits in the 5XFAD mouse model of Alzheimer's disease, Front Aging Neurosci, vol.24, p.96, 2013.
URL : https://hal.archives-ouvertes.fr/hal-01703910

N. Ginovart, Imaging the dopamine system with in vivo [11C]raclopride displacement studies: understanding the true mechanism, Mol Imaging Biol, vol.7, pp.45-52, 2005.

N. Ginovart, L. Galineau, M. Willeit, R. Mizrahi, P. M. Bloomfield et al., Binding characteristics and sensitivity to endogenous dopamine of [11C]-(+)PHNO, a new agonist radiotracer for imaging the high-affinity state of D2 receptors in vivo using positron emission tomography, J Neurochem, vol.97, pp.1089-1103, 2006.

N. Ginovart, W. Hassoun, D. Le-bars, D. Weissmann, and V. Leviel, , 2000.

, MPPF, a fluoro analog of WAY-100635 for visualization of 5-HT(1a) receptors, Synapse, vol.35, pp.192-200

J. Gonzalez-maeso, I. Torre, R. Rodriguez-puertas, J. A. Garcia-sevilla, J. Guimon et al., Effects of age, postmortem delay and storage time on receptor-mediated activation of Gproteins in human brain, Neuropsychopharmacology, vol.26, pp.468-478, 2002.

H. Gozlan, S. Thibault, A. M. Laporte, L. Lima, and M. Hamon, The selective 5-HT1A antagonist radioligand [3H]WAY 100635 labels both G-protein-coupled and free 5-HT1A receptors in rat brain membranes, Eur J Pharmacol, vol.288, pp.173-186, 1995.

J. A. Gray and B. L. Roth, Paradoxical trafficking and regulation of 5-HT(2A) receptors by agonists and antagonists, Brain Res Bull, vol.56, pp.441-451, 2001.

C. Gross, X. Zhuang, K. Stark, S. Ramboz, R. Oosting et al., Serotonin1A receptor acts during development to establish normal anxiety-like behaviour in the adult, Nature, vol.416, pp.396-400, 2002.

J. X. Haensel, A. Spain, and C. Martin, A systematic review of physiological methods in rodent pharmacological MRI studies, Psychopharmacology (Berl), vol.232, pp.489-499, 2015.

M. Hajos, E. Hajos-korcsok, and T. Sharp, Role of the medial prefrontal cortex in 5-HT1A receptorinduced inhibition of 5-HT neuronal activity in the rat, Br J Pharmacol, vol.126, pp.1741-1750, 1999.

M. Hajos, C. D. Richards, A. D. Szekely, and T. Sharp, An electrophysiological and neuroanatomical study of the medial prefrontal cortical projection to the midbrain raphe nuclei in the rat, Neuroscience, vol.87, pp.95-108, 1998.

H. Hall, C. Lundkvist, C. Halldin, L. Farde, V. W. Pike et al., Autoradiographic localization of 5-HT1A receptors in the postmortem human brain using, Brain Res, vol.745, pp.96-108, 1997.

M. D. Hall, S. El-mestikawy, M. B. Emerit, L. Pichat, M. Hamon et al., 3H]8-hydroxy-2(di-n-propylamino)tetralin binding to pre-and postsynaptic 5-hydroxytryptamine sites in various regions of the rat brain, J Neurochem, vol.44, pp.1685-1696, 1985.

G. M. Halliday, H. L. Mccann, R. Pamphlett, W. S. Brooks, H. Creasey et al., Brain stem serotonin-synthesizing neurons in Alzheimer's disease: a clinicopathological correlation, Acta Neuropathol, vol.84, pp.638-650, 1992.

M. Hamon, H. Gozlan, S. El-mestikawy, M. B. Emerit, F. Bolanos et al., The central 5HT1A receptors: pharmacological, biochemical, functional, and regulatory properties, Ann N Y Acad Sci, vol.600, pp.129-131, 1990.

J. Hannon and D. Hoyer, Molecular biology of 5-HT receptors, Behav Brain Res, vol.195, pp.198-213, 2008.

L. K. Heisler, H. M. Chu, T. J. Brennan, J. A. Danao, P. Bajwa et al., Elevated anxiety and antidepressant-like responses in serotonin 5-HT1A receptor mutant mice, Proc Natl Acad Sci U S A, vol.95, pp.15049-15054, 1998.

N. Hendry, I. Christie, E. A. Rabiner, M. Laruelle, and J. Watson, In vitro assessment of the agonist properties of the novel 5-HT1A receptor ligand, CUMI-101 (MMP), in rat brain tissue, Nucl Med Biol, vol.38, pp.273-277, 2011.

J. G. Hensler, Serotonergic modulation of the limbic system, Neurosci Biobehav Rev, vol.30, pp.203-214, 2006.

C. Hercend, J. Hannon, and D. Hoyer, Les récepteurs sérotoninergiques. Spreux-Varoquaux, O. Sérotonine: Aspects biologiques et cliniques. Lavoisier, pp.13-56, 2012.

K. Herholz, Cerebral glucose metabolism in preclinical and prodromal Alzheimer's disease, Expert Rev Neurother, vol.10, pp.1667-1673, 2010.

L. Hertz, D. L. Rothman, B. Li, and L. Peng, Chronic SSRI stimulation of astrocytic 5-HT2B receptors change multiple gene expressions/editings and metabolism of glutamate, glucose and glycogen: a potential paradigm shift, Front Behav Neurosci, vol.9, p.25, 2015.

P. Heusler, C. Palmier, S. Tardif, S. Bernois, F. C. Colpaert et al., )H]-F13640, a novel, selective and high-efficacy serotonin 5-HT(1A) receptor agonist radioligand, Naunyn Schmiedebergs Arch Pharmacol, vol.382, issue.3, pp.321-330, 2010.

P. Heusler, P. J. Pauwels, T. Wurch, A. Newman-tancredi, J. Tytgat et al., Differential ion current activation by human 5-HT(1A) receptors in Xenopus oocytes: evidence for agonist-directed trafficking of receptor signalling, Neuropharmacology, vol.49, pp.963-976, 2005.

E. Hirani, J. Opacka-juffry, R. Gunn, I. Khan, T. Sharp et al., Pindolol occupancy of 5HT(1A) receptors measured in vivo using small animal positron emission tomography with carbon-11 labeled WAY 100635, Synapse, vol.36, pp.330-341, 2000.

W. D. Hirst, N. Y. Cheung, M. Rattray, G. W. Price, and G. P. Wilkin, Cultured astrocytes express messenger RNA for multiple serotonin receptor subtypes, without functional coupling of 5-HT1 receptor subtypes to adenylyl cyclase, Brain Res Mol Brain Res, vol.61, pp.90-99, 1998.

J. Hirvonen, J. Kajander, T. Allonen, V. Oikonen, K. Nagren et al., Measurement of serotonin 5-HT1A receptor binding using positron emission tomography and [carbonyl-(11)C]WAY100635-considerations on the validity of cerebellum as a reference region, J Cereb Blood Flow Metab, vol.27, pp.185-195, 2007.

S. Hjorth, C. S. Suchowski, and M. P. Galloway, Evidence for 5-HT autoreceptor-mediated, nerve impulse-independent, control of 5-HT synthesis in the rat brain, Synapse, vol.19, pp.170-176, 1995.

J. D. Holbrook, C. H. Gill, N. Zebda, J. P. Spencer, R. Leyland et al., Characterisation of 5-HT3C, 5-HT3D and 5-HT3E receptor subunits: evolution, distribution and function, J Neurochem, vol.108, pp.384-396, 2009.

J. P. Hornung, The human raphe nuclei and the serotonergic system, J Chem Neuroanat, vol.26, pp.331-343, 2003.

G. C. Houston, N. G. Papadakis, T. A. Carpenter, L. D. Hall, B. Mukherjee et al., Mapping of brain activation in response to pharmacological agents using fMRI in the rat, Magn Reson Imaging, vol.19, pp.905-919, 2001.

D. Hoyer, Serotonin 5-HT3, 5-HT4, and 5-HT-M receptors, Neuropsychopharmacology, vol.3, pp.371-383, 1990.

D. Hoyer, 5-HT Receptor Nomenclature: Naming Names, Does It Matter? A Tribute to Maurice Rapport, ACS Chem Neurosci, vol.8, pp.908-919, 2017.

D. Hoyer, D. E. Clarke, J. R. Fozard, P. R. Hartig, G. R. Martin et al., International Union of Pharmacology classification of receptors for 5hydroxytryptamine (Serotonin), Pharmacol Rev, vol.46, pp.157-203, 1994.

S. Hume, E. Hirani, J. Opacka-juffry, R. Myers, C. Townsend et al., Effect of 5HT on binding of [(11)C] WAY 100635 to 5-HT(IA) receptors in rat brain, assessed using in vivo microdialysis nd PET after fenfluramine, Synapse, vol.41, pp.150-159, 2001.

S. P. Hume, R. N. Gunn, and T. Jones, Pharmacological constraints associated with positron emission tomographic scanning of small laboratory animals, Eur J Nucl Med, vol.25, pp.173-176, 1998.

D. Hwang, Y. Huang, K. Ngo, L. Savenkova, N. Guo et al., Preparation and evaluation of [11C]-labeled 5HT1A agonist: (R)-10-Methyl-11-hydroxyaporphine, J Label Compd Radiopharm, vol.44, pp.176-178, 2001.

D. Hwang, K. Ngo, L. Savenkova, Y. Huang, N. Guo et al., ,2,3,4Tetrahydronaphth-1-YL)-Piperidine (FBP), J Label Compd Radiopharm, vol.44, pp.179-181, 2001.

H. Iderberg, A. C. Mccreary, M. A. Varney, M. A. Cenci, and A. Newman-tancredi, Activity of serotonin 5-HT(1A) receptor 'biased agonists' in rat models of Parkinson's disease and L-DOPAinduced dyskinesia, Neuropharmacology, vol.93, pp.52-67, 2015.

H. Iderberg, A. C. Mccreary, M. A. Varney, M. S. Kleven, W. Koek et al., NLX-112, a novel 5-HT1A receptor agonist for the treatment of LDOPA-induced dyskinesia: Behavioral and neurochemical profile in rat, Exp Neurol, vol.271, pp.335-350, 2015.

T. Ishibashi and Y. Ohno, Antiparkinsonian actions of a selective 5-HT1A agonist, tandospirone, in rats, Biog Amines, vol.8, pp.329-338, 2004.

B. L. Jacobs and E. C. Azmitia, Structure and function of the brain serotonin system, Physiol Rev, vol.72, pp.165-229, 1992.

E. M. Jagoda, L. Lang, J. Tokugawa, A. Simmons, Y. Ma et al., Development of 5-HT1A receptor radioligands to determine receptor density and changes in endogenous 5-HT, Synapse, vol.59, pp.330-341, 2006.

B. G. Jenkins, Pharmacologic magnetic resonance imaging (phMRI): imaging drug action in the brain, Neuroimage, vol.62, pp.1072-1085, 2012.

M. Jiang, M. S. Gold, G. Boulay, K. Spicher, M. Peyton et al., Multiple neurological abnormalities in mice deficient in the G protein Go, Proc Natl Acad Sci U S A, vol.95, pp.3269-3274, 1998.

M. Jiang, K. Spicher, G. Boulay, A. Martin-requero, C. A. Dye et al., Mouse gene knockout and knockin strategies in application to alpha subunits of Gi/Go family of G proteins, Methods Enzymol, vol.344, pp.277-298, 2002.

K. Jin, V. Galvan, L. Xie, X. O. Mao, O. F. Gorostiza et al., Enhanced neurogenesis in Alzheimer's disease transgenic (PDGF-APPSw,Ind) mice, Proc Natl Acad Sci U S A, vol.101, pp.13363-13367, 2004.

K. Jin, A. L. Peel, X. O. Mao, L. Xie, B. A. Cottrell et al., Increased hippocampal neurogenesis in Alzheimer's disease, Proc Natl Acad Sci U S A, vol.101, pp.343-347, 2004.

L. Q. Jin, H. Y. Wang, and E. Friedman, Stimulated D(1) dopamine receptors couple to multiple Galpha proteins in different brain regions, J Neurochem, vol.78, pp.981-990, 2001.

K. W. Johnson, J. M. Schaus, M. M. Durkin, J. E. Audia, S. W. Kaldor et al., 5-HT1F receptor agonists inhibit neurogenic dural inflammation in guinea pigs, Neuroreport, vol.8, pp.2237-2240, 1997.

R. G. Johnson, D. Fiorella, J. C. Winter, and R. A. Rabin, 3H]8-OH-DPAT labels a 5-HT site coupled to inhibition of phosphoinositide hydrolysis in the dorsal raphe, Eur J Pharmacol, vol.329, pp.99-106, 1997.

B. J. Jones and T. P. Blackburn, The medical benefit of 5-HT research, Pharmacol Biochem Behav, vol.71, pp.555-568, 2002.

J. Katayama, T. Yakushiji, and N. Akaike, Characterization of the K+ current mediated by 5-HT1A receptor in the acutely dissociated rat dorsal raphe neurons, Brain Res, vol.745, pp.283-292, 1997.

P. A. Kelly, C. J. Davis, and G. M. Goodwin, Differential patterns of local cerebral glucose utilization in response to 5-hydroxytryptamine agonists, Neuroscience, vol.25, pp.907-915, 1988.

T. Kenakin, Agonist-receptor efficacy. II. Agonist trafficking of receptor signals, Trends Pharmacol Sci, vol.16, pp.232-238, 1995.

T. Kenakin, What is pharmacological 'affinity'? Relevance to biased agonism and antagonism, Trends Pharmacol Sci, vol.35, pp.434-441, 2014.

T. Kenakin, New Lives for Seven Transmembrane Receptors as Drug Targets, Trends Pharmacol Sci, vol.36, pp.705-706, 2015.

T. Kenakin and A. Christopoulos, Signalling bias in new drug discovery: detection, quantification and therapeutic impact, Nat Rev Drug Discov, vol.12, pp.205-216, 2013.

V. Kepe, J. R. Barrio, S. C. Huang, L. Ercoli, P. Siddarth et al., Serotonin 1A receptors in the living brain of Alzheimer's disease patients, Proc Natl Acad Sci U S A, vol.103, pp.702-707, 2006.

C. W. Kerr and G. A. Bishop, The physiological effects of serotonin are mediated by the 5HT1A receptor in the cat's cerebellar cortex, Brain Res, vol.591, pp.253-260, 1992.

H. K. Kia, M. J. Brisorgueil, G. Daval, X. Langlois, M. Hamon et al., Serotonin1A receptors are expressed by a subpopulation of cholinergic neurons in the rat medial septum and diagonal band of Broca-a double immunocytochemical study, Neuroscience, vol.74, pp.143-154, 1996.

H. K. Kia, M. J. Brisorgueil, M. Hamon, A. Calas, and D. Verge, Ultrastructural localization of 5hydroxytryptamine1A receptors in the rat brain, J Neurosci Res, vol.46, pp.697-708, 1996.

H. K. Kia, M. C. Miquel, M. J. Brisorgueil, G. Daval, M. Riad et al., Immunocytochemical localization of serotonin1A receptors in the rat central nervous system, J Comp Neurol, vol.365, pp.289-305, 1996.

H. C. Kinney, G. B. Richerson, S. M. Dymecki, R. A. Darnall, and E. E. Nattie, The brainstem and serotonin in the sudden infant death syndrome, Annu Rev Pathol, vol.4, pp.517-550, 2009.

T. Kishi, H. Y. Meltzer, Y. Matsuda, and N. Iwata, Azapirone 5-HT1A receptor partial agonist treatment for major depressive disorder: systematic review and meta-analysis, Psychol Med, vol.44, pp.2255-69, 2014.
DOI : 10.1017/s0033291713002857

B. K. Kobilka, T. Frielle, S. Collins, T. Yang-feng, T. S. Kobilka et al., An intronless gene encoding a potential member of the family of receptors coupled to guanine nucleotide regulatory proteins, Nature, vol.329, pp.75-79, 1987.

C. Kohler and H. Steinbusch, Identification of serotonin and non-serotonin-containing neurons of the mid-brain raphe projecting to the entorhinal area and the hippocampal formation. A combined immunohistochemical and fluorescent retrograde tracing study in the rat brain, Neuroscience, vol.7, pp.951-975, 1982.

B. E. Kosofsky and M. E. Molliver, The serotoninergic innervation of cerebral cortex: different classes of axon terminals arise from dorsal and median raphe nuclei, Synapse, vol.1, pp.153-168, 1987.

A. Kovoor and H. A. Lester, Gi Irks GIRKs, Neuron, vol.33, pp.6-8, 2002.
DOI : 10.1016/s0896-6273(01)00572-4

URL : https://doi.org/10.1016/s0896-6273(01)00572-4

J. S. Kumar and J. J. Mann, PET tracers for 5-HT(1A) receptors and uses thereof, Drug Discov Today, vol.12, pp.748-756, 2007.
DOI : 10.1016/j.drudis.2007.07.008

J. S. Kumar and J. J. Mann, PET tracers for serotonin receptors and their applications, Cent Nerv Syst Agents Med Chem, vol.14, pp.96-112, 2014.
DOI : 10.2174/1871524914666141030124316

URL : http://europepmc.org/articles/pmc4330993?pdf=render

J. S. Kumar, J. Prabhakaran, V. J. Majo, M. S. Milak, S. C. Hsiung et al., methoxyphenyl)piperazin-1-yl)butyl)-4methyl-1,2,4-triazine-3,5(2H ,4H)dione in nonhuman primates, Eur J Nucl Med Mol Imaging, vol.34, issue.4, pp.1050-1060, 2007.

H. F. Kung, D. A. Stevenson, Z. P. Zhuang, M. P. Kung, D. Frederick et al., Synapse, vol.23, pp.344-346, 1996.

M. P. Kung, Z. P. Zhuang, D. Frederick, and H. F. Kung, In vivo binding of [123I]4-(2'methoxyphenyl)-1-[2'-(N-2"-pyridinyl)-p-iodobenzamido-]ethyl-piperazine, p-MPPI, to 5-HT1A receptors in rat brain, Synapse, vol.18, pp.359-366, 1994.

N. Kushwaha, S. C. Harwood, A. M. Wilson, M. Berger, L. H. Tecott et al., Molecular determinants in the second intracellular loop of the 5-hydroxytryptamine-1A receptor for G-protein coupling, Mol Pharmacol, vol.69, pp.1518-1544, 2006.

H. Kusserow, B. Davies, H. Hortnagl, I. Voigt, T. Stroh et al., Reduced anxiety-related behaviour in transgenic mice overexpressing serotonin 1A receptors, Brain Res Mol Brain Res, vol.129, pp.104-116, 2004.
DOI : 10.1016/j.molbrainres.2004.06.028

G. Lacan, A. Plenevaux, D. J. Rubins, B. M. Way, C. Defraiteur et al., Cyclosporine, a P-glycoprotein modulator, increases [18F]MPPF uptake in rat brain and peripheral tissues: microPET and ex vivo studies, Eur J Nucl Med Mol Imaging, vol.35, pp.2256-2266, 2008.

E. Lacivita, P. Di-pilato, P. De-giorgio, N. A. Colabufo, F. Berardi et al., The therapeutic potential of 5-HT1A receptors: a patent review, Expert Opin Ther Pat, vol.22, pp.887-902, 2012.

M. K. Lai, S. W. Tsang, M. M. Esiri, P. T. Francis, P. T. Wong et al., Differential involvement of hippocampal serotonin1A receptors and re-uptake sites in non-cognitive behaviors of Alzheimer's disease, Psychopharmacology (Berl), vol.213, pp.431-439, 2011.

M. K. Lai, S. W. Tsang, P. T. Francis, J. Keene, T. Hope et al., Postmortem serotoninergic correlates of cognitive decline in Alzheimer's disease, Neuroreport, vol.13, pp.1175-1178, 2002.

S. Lancelot and L. Zimmer, Small-animal positron emission tomography as a tool for neuropharmacology, Trends Pharmacol Sci, vol.31, pp.411-417, 2010.
DOI : 10.1016/j.tips.2010.06.002

S. Lancelot, N. Costes, L. Lemoine, and L. Zimmer, Development and evaluation of a digital atlas for PET neuroimaging in domestic cat (Felis catus), European Journal of Nuclear Medicine and Molecular Imaging, vol.37, pp.387-387, 2010.

S. Lancelot, R. Roche, A. Slimen, C. Bouillot, E. Levigoureux et al., A multi-atlas based method for automated anatomical rat brain MRI segmentation and extraction of PET activity, PLoS One, vol.9, 2014.
URL : https://hal.archives-ouvertes.fr/hal-01128452

K. L. Lanctot, D. F. Hussey, N. Herrmann, S. E. Black, P. M. Rusjan et al., A positron emission tomography study of 5-hydroxytryptamine1A receptors in Alzheimer disease, Am J Geriatr Psychiatry, vol.15, pp.888-898, 2007.

L. Lanfumey and M. Hamon, Central 5-HT(1A) receptors: regional distribution and functional characteristics, Nucl Med Biol, vol.27, pp.429-435, 2000.
DOI : 10.1016/s0969-8051(00)00107-4

L. Lanfumey and M. Hamon, 5-HT1 receptors, Curr Drug Targets CNS Neurol Disord, vol.3, pp.1-10, 2004.
DOI : 10.2174/1568007043482570

URL : https://hal.archives-ouvertes.fr/hal-01104390

L. Lang, E. Jagoda, B. Schmall, B. K. Vuong, H. R. Adams et al., Development of fluorine-18-labeled 5-HT1A antagonists, J Med Chem, vol.42, pp.1576-1586, 1999.

G. Lappin and S. Temple, Radiotracers in drug development, 2006.

M. Laruelle, Imaging synaptic neurotransmission with in vivo binding competition techniques: a critical review, J Cereb Blood Flow Metab, vol.20, pp.423-451, 2000.

K. L. Laugwitz, A. Allgeier, S. Offermanns, K. Spicher, J. Van-sande et al., The human thyrotropin receptor: a heptahelical receptor capable of stimulating members of all four G protein families, Proc Natl Acad Sci, pp.116-120, 1996.

M. Lauritzen, C. Mathiesen, K. Schaefer, and K. J. Thomsen, Neuronal inhibition and excitation, and the dichotomic control of brain hemodynamic and oxygen responses, Neuroimage, vol.62, p.1040, 2012.
DOI : 10.1016/j.neuroimage.2012.01.040

L. Bars, D. Lemaire, C. Ginovart, N. Plenevaux, A. Aerts et al., High-yield radiosynthesis and preliminary in vivo evaluation of p-[18F]MPPF, a fluoro analog of WAY-100635, Nucl Med Biol, vol.25, pp.343-350, 1998.

L. Poul, E. Boni, C. Hanoun, N. Laporte, A. M. Laaris et al., Differential adaptation of brain 5-HT1A and 5-HT1B receptors and 5-HT transporter in rats treated chronically with fluoxetine, Neuropharmacology, vol.39, pp.110-122, 2000.

L. Lemoine, G. Becker, B. Vacher, T. Billard, S. Lancelot et al., Radiosynthesis and preclinical evaluation of 18F-F13714 as a fluorinated 5-HT1A receptor agonist radioligand for PET neuroimaging, J Nucl Med, vol.53, pp.969-976, 2012.
URL : https://hal.archives-ouvertes.fr/hal-00821174

L. Lemoine, M. Verdurand, B. Vacher, E. Blanc, D. Le-bars et al., , 2010.

, F15599, a novel 5-HT1A receptor agonist, as a radioligand for PET neuroimaging, Eur J Nucl Med Mol Imaging, vol.37, pp.594-605

E. S. Levitt, B. J. Hunnicutt, S. J. Knopp, J. T. Williams, and J. M. Bissonnette, A selective 5-HT1a receptor agonist improves respiration in a mouse model of Rett syndrome, J Appl Physiol, vol.115, pp.1626-1633, 1985.

J. E. Leysen, 5-HT2 receptors, Curr Drug Targets CNS Neurol Disord, vol.3, pp.11-26, 2004.
DOI : 10.2174/1568007043482598

C. J. Liew, Y. M. Lim, R. Bonwetsch, S. Shamim, S. Sato et al., 18F-FCWAY and 18F-FDG PET in MRI-negative temporal lobe epilepsy, Epilepsia, vol.50, pp.234-239, 2009.
DOI : 10.1111/j.1528-1167.2008.01789.x

URL : https://onlinelibrary.wiley.com/doi/pdf/10.1111/j.1528-1167.2008.01789.x

S. H. Lin, L. T. Lee, and Y. K. Yang, Serotonin and mental disorders: a concise review on molecular neuroimaging evidence, Clin Psychopharmacol Neurosci, vol.12, pp.196-202, 2014.
DOI : 10.9758/cpn.2014.12.3.196

URL : http://www.cpn.or.kr/journal/download_pdf.php?doi=10.9758/cpn.2014.12.3.196

S. L. Lin, S. Setya, N. N. Johnson-farley, and D. S. Cowen, Differential coupling of 5-HT(1) receptors to G proteins of the G(i) family, Br J Pharmacol, vol.136, pp.1072-1078, 2002.

L. Llado-pelfort, M. B. Assie, A. Newman-tancredi, F. Artigas, and P. Celada, Preferential in vivo action of F15599, a novel 5-HT(1A) receptor agonist, at postsynaptic 5-HT(1A) receptors, Br J Pharmacol, vol.160, pp.1929-1940, 2010.

L. Llado-pelfort, N. Santana, V. Ghisi, F. Artigas, and P. Celada, 5-HT1A receptor agonists enhance pyramidal cell firing in prefrontal cortex through a preferential action on GABA interneurons, Cereb Cortex, vol.22, pp.1487-1497, 2012.

J. Logan, Graphical analysis of PET data applied to reversible and irreversible tracers, Nucl Med Biol, vol.27, pp.661-670, 2000.

D. E. Lorke, G. Lu, E. Cho, and D. T. Yew, Serotonin 5-HT2A and 5-HT6 receptors in the prefrontal cortex of Alzheimer and normal aging patients, BMC Neurosci, vol.7, p.36, 2006.

I. Lucki, The spectrum of behaviors influenced by serotonin, Biol Psychiatry, vol.44, pp.151-162, 1998.

M. Luttgen, S. O. Ogren, and B. Meister, 5-HT1A receptor mRNA and immunoreactivity in the rat medial septum/diagonal band of Broca-relationships to GABAergic and cholinergic neurons, J Chem Neuroanat, vol.29, pp.93-111, 2005.

L. M. Luttrell, S. Maudsley, and L. M. Bohn, Fulfilling the Promise of "Biased" G Protein-Coupled Receptor Agonism, Mol Pharmacol, vol.88, pp.579-588, 2015.

A. Maassenvandenbrink, M. N. Vergouwe, R. A. Ophoff, P. R. Saxena, M. D. Ferrari et al., 5-HT1B receptor polymorphism and clinical response to sumatriptan, Headache, vol.38, pp.288-291, 1998.

K. Madsen, W. J. Neumann, K. Holst, L. Marner, M. T. Haahr et al., Cerebral serotonin 4 receptors and amyloid-beta in early Alzheimer's disease, J Alzheimers Dis, vol.26, pp.457-466, 2011.

J. Maeda, T. Suhara, M. Ogawa, T. Okauchi, K. Kawabe et al., In vivo binding properties of [carbonyl-11C]WAY-100635: effect of endogenous serotonin, Synapse, vol.40, pp.122-129, 2001.

J. K. Mai and G. Paxinos, Atlas of the human brain, 1997.

J. B. Mandeville, C. H. Liu, W. Vanduffel, J. J. Marota, and B. G. Jenkins, Data collection and analysis strategies for phMRI, Neuropharmacology, vol.84, pp.65-78, 2014.
DOI : 10.1016/j.neuropharm.2014.02.018

URL : http://europepmc.org/articles/pmc4058391?pdf=render

C. Mannoury-la-cour, C. Boni, N. Hanoun, K. P. Lesch, M. Hamon et al., Functional consequences of 5-HT transporter gene disruption on 5-HT(1a) receptor-mediated regulation of dorsal raphe and hippocampal cell activity, J Neurosci, vol.21, pp.2178-2185, 2001.

C. Mannoury-la-cour, S. El-mestikawy, N. Hanoun, M. Hamon, and L. Lanfumey, Regional differences in the coupling of 5-hydroxytryptamine-1A receptors to G proteins in the rat brain, Mol Pharmacol, vol.70, pp.1013-1021, 2006.

D. Marazziti, L. Palego, A. Giromella, M. R. Mazzoni, F. Borsini et al., Region-dependent effects of flibanserin and buspirone on adenylyl cyclase activity in the human brain, Int J Neuropsychopharmacol, vol.5, pp.131-140, 2002.

L. Marner, V. G. Frokjaer, J. Kalbitzer, S. Lehel, K. Madsen et al., Loss of serotonin 2A receptors exceeds loss of serotonergic projections in early Alzheimer's disease: a combined, Neurobiol Aging, vol.33, pp.479-487, 2012.

C. Martin and N. R. Sibson, Pharmacological MRI in animal models: a useful tool for 5-HT research?, Neuropharmacology, vol.55, pp.1038-1047, 2008.

D. Martinez, D. Hwang, O. Mawlawi, M. Slifstein, J. Kent et al., Differential occupancy of somatodendritic and postsynaptic 5HT(1A) receptors by pindolol: a dose-occupancy study with [11C]WAY 100635 and positron emission tomography in humans, Neuropsychopharmacology, vol.24, pp.209-229, 2001.

S. Mary, M. Damian, M. Louet, N. Floquet, J. A. Fehrentz et al., Ligands and signaling proteins govern the conformational landscape explored by a G proteincoupled receptor, Proc Natl Acad Sci U S A, vol.109, pp.8304-8309, 2012.
URL : https://hal.archives-ouvertes.fr/hal-00713574

C. A. Massey, K. E. Iceman, S. L. Johansen, Y. Wu, M. B. Harris et al., Isoflurane abolishes spontaneous firing of serotonin neurons and masks their pH/CO(2) chemosensitivity, J Neurophysiol, vol.113, pp.2879-2888, 2015.

C. A. Mathis, N. R. Simpson, K. Mahmood, P. E. Kinahan, and M. A. Mintun, 11C]WAY 100635: a radioligand for imaging 5-HT1A receptors with positron emission tomography, Life Sci, vol.55, pp.403-407, 1994.

C. A. Mathis, Y. Huang, and N. R. Simpson, Synthesis and evaluation of 5-HT1A agonists as radioligands : failure of G protein-coupled receptor agonists as in vivo imaging agents, J Labelled Compd Radiopharm, vol.40, pp.563-564, 1997.

J. L. Maurel, J. M. Autin, P. Funes, A. Newman-tancredi, F. Colpaert et al., Highefficacy 5-HT1A agonists for antidepressant treatment: a renewed opportunity, J Med Chem, vol.50, pp.5024-5033, 2007.

D. E. Mcbean, J. Sharkey, I. M. Ritchie, and P. A. Kelly, Cerebrovascular and functional consequences of 5-HT1A receptor activation, Brain Res, vol.555, pp.159-163, 1991.

A. C. Mccreary, M. A. Varney, and A. Newman-tancredi, The novel 5-HT1A receptor agonist, NLX112 reduces l-DOPA-induced abnormal involuntary movements in rat: A chronic administration study with microdialysis measurements, Neuropharmacology, vol.105, pp.651-660, 2016.

S. Mckie, C. Del-ben, R. Elliott, S. Williams, N. Del-vai et al., Neuronal effects of acute citalopram detected by pharmacoMRI, Psychopharmacology (Berl), vol.180, pp.680-686, 2005.

S. M. Meadows, N. E. Chambers, M. M. Conti, S. C. Bossert, C. Tasber et al., Characterizing the differential roles of striatal 5-HT1A autoand hetero-receptors in the reduction of l-DOPA-induced dyskinesia, Exp Neurol, vol.292, pp.168-178, 2017.

H. Y. Meltzer, Z. Li, Y. Kaneda, and J. Ichikawa, Serotonin receptors: their key role in drugs to treat schizophrenia, Prog Neuropsychopharmacol Biol Psychiatry, vol.27, pp.1159-1172, 2003.

J. Mendez, T. M. Kadia, R. K. Somayazula, K. I. El-badawi, and D. S. Cowen, Differential coupling of serotonin 5-HT1A and 5-HT1B receptors to activation of ERK2 and inhibition of adenylyl cyclase in transfected CHO cells, J Neurochem, vol.73, pp.162-168, 1999.

A. Meneses, Serotonin, neural markers, and memory, Front Pharmacol, vol.6, p.143, 2015.

I. Merlet, K. Ostrowsky, N. Costes, P. Ryvlin, J. Isnard et al., 5-HT1A receptor binding and intracerebral activity in temporal lobe epilepsy: an [18F]MPPF-PET study, Brain, vol.127, pp.900-913, 2004.

J. H. Meyer, Imaging the serotonin transporter during major depressive disorder and antidepressant treatment, J Psychiatry Neurosci, vol.32, pp.86-102, 2007.

D. N. Middlemiss, A. M. Palmer, N. Edel, and D. M. Bowen, Binding of the novel serotonin agonist 8-hydroxy-2-(di-n-propylamino) tetralin in normal and Alzheimer brain, J Neurochem, vol.46, pp.993-996, 1986.

M. S. Milak, C. Delorenzo, F. Zanderigo, J. Prabhakaran, J. S. Kumar et al., In vivo quantification of human serotonin 1A receptor using 11C-CUMI-101, an agonist PET radiotracer, J Nucl Med, vol.51, pp.1892-1900, 2010.

M. S. Milak, A. J. Severance, J. Prabhakaran, J. S. Kumar, V. J. Majo et al., In vivo serotonin-sensitive binding of [11C]CUMI-101: a serotonin 1A receptor agonist positron emission tomography radiotracer, J Cereb Blood Flow Metab, vol.31, pp.243-249, 2011.

M. J. Millan, P. Marin, J. Bockaert, and C. Mannoury-la-cour, Signaling at G-protein-coupled serotonin receptors: recent advances and future research directions, Trends Pharmacol Sci, vol.29, pp.454-464, 2008.

M. J. Millan, A. Newman-tancredi, D. Duqueyroix, and D. Cussac, Agonist properties of pindolol at h5-HT1A receptors coupled to mitogen-activated protein kinase, Eur J Pharmacol, vol.424, pp.13-17, 2001.

P. Millet, M. Moulin, A. Bartoli, A. Del-guerra, N. Ginovart et al., In vivo quantification of 5-HT1A-[18F]MPPF interactions in rats using the YAP-(S)PET scanner and a beta-microprobe, Neuroimage, vol.41, pp.823-834, 2008.

M. C. Miquel, E. Doucet, C. Boni, S. El-mestikawy, L. Matthiessen et al., Central serotonin1A receptors : respective distributions of encoding mRNA, receptor protein and binding sites by in situ hybridization histochemistry, radioimmunochemistry and autoradiographic mapping in the rat brain, Neurochem Int, vol.19, pp.453-465, 1991.

M. C. Miquel, E. Doucet, M. Riad, J. Adrien, D. Verge et al., Effect of the selective lesion of serotoninergic neurons on the regional distribution of 5-HT1A receptor mRNA in the rat brain, Brain Res Mol Brain Res, vol.14, pp.357-362, 1992.

K. Mizukami, M. Ishikawa, H. Akatsu, E. E. Abrahamson, M. D. Ikonomovic et al., An immunohistochemical study of the serotonin 1A receptor in the hippocampus of subjects with Alzheimer's disease, Neuropathology, vol.31, pp.503-509, 2011.

H. Mochizuki, T. Amano, T. Seki, H. Matsubayashi, C. Mitsuhata et al., Role of C-terminal region in the functional regulation of rat serotonin transporter (SERT), Neurochem Int, vol.46, pp.93-105, 2005.

M. E. Molliver, Serotonergic neuronal systems: what their anatomic organization tells us about function, J Clin Psychopharmacol, vol.7, pp.3-23, 1987.

R. Mongeau, S. A. Welner, R. Quirion, and B. E. Suranyi-cadotte, Further evidence for differential affinity states of the serotonin1A receptor in rat hippocampus, Brain Res, vol.590, pp.229-238, 1992.

F. P. Monnet, G. Debonnel, R. Bergeron, B. Gronier, and C. De-montigny, The effects of sigma ligands and of neuropeptide Y on N-methyl-D-aspartate-induced neuronal activation of CA3 dorsal hippocampus neurones are differentially affected by pertussin toxin, Br J Pharmacol, vol.112, pp.709-715, 1994.

M. Moulin-sallanon, Y. Charnay, N. Ginovart, P. Perret, L. Lanfumey et al., Acute and chronic effects of citalopram on 5-HT1A receptor-labeling by [18F]MPPF and-coupling to receptors-G proteins, Synapse, vol.63, pp.106-116, 2009.

Y. Mu and F. H. Gage, Adult hippocampal neurogenesis and its role in Alzheimer's disease, Mol Neurodegener, vol.6, p.85, 2011.

T. Mueggler, F. Razoux, H. Russig, A. Buehler, T. B. Franklin et al., Mapping of CBV changes in 5-HT(1A) terminal fields by functional MRI in the mouse brain, Eur Neuropsychopharmacol, vol.21, pp.344-353, 2011.

K. Mukaida, T. Shichino, S. Koyanagi, S. Himukashi, and K. Fukuda, Activity of the serotonergic system during isoflurane anesthesia, Anesth Analg, vol.104, pp.836-839, 2007.
DOI : 10.1213/01.ane.0000255200.42574.22

URL : http://intl.anesthesia-analgesia.org/content/104/4/836.full.pdf

D. L. Murphy, A. Lerner, G. Rudnick, and K. P. Lesch, Serotonin transporter: gene, genetic disorders, and pharmacogenetics, Mol Interv, vol.4, pp.109-123, 2004.
DOI : 10.1124/mi.4.2.8

R. Narendran, D. R. Hwang, M. Slifstein, P. S. Talbot, D. Erritzoe et al., vivo vulnerability to competition by endogenous dopamine: comparison of the D2 receptor agonist radiotracer, vol.52, pp.188-208, 2004.

D. L. Nelson, 5-HT5 receptors, Curr Drug Targets CNS Neurol Disord, vol.3, pp.53-58, 2004.
DOI : 10.2174/1568007043482606

A. Neumeister, E. Bain, A. C. Nugent, R. E. Carson, O. Bonne et al., Reduced serotonin type 1A receptor binding in panic disorder, J Neurosci, vol.24, pp.589-591, 2004.
DOI : 10.1523/jneurosci.4921-03.2004

URL : http://www.jneurosci.org/content/jneuro/24/3/589.full.pdf

A. Newman-tancredi, The importance of 5-HT1A receptor agonism in antipsychotic drug action: rationale and perspectives, Curr Opin Investig Drugs, vol.11, pp.802-812, 2010.

A. Newman-tancredi, Biased agonism at serotonin 5-HT1A receptors: preferential postsynaptic activity for improved therapy of CNS disorders, Neuropsychiatry, vol.1, pp.149-164, 2011.

A. Newman-tancredi, D. Cussac, L. Marini, and M. J. Millan, Antibody capture assay reveals bellshaped concentration-response isotherms for h5-HT(1A) receptor-mediated Galpha(i3) activation: conformational selection by high-efficacy agonists, and relationship to trafficking of receptor signaling, Mol Pharmacol, vol.62, pp.590-601, 2002.

A. Newman-tancredi and M. S. Kleven, Comparative pharmacology of antipsychotics possessing combined dopamine D2 and serotonin 5-HT1A receptor properties, Psychopharmacology (Berl), vol.216, pp.451-473, 2011.

A. Newman-tancredi, J. C. Martel, M. B. Assie, J. Buritova, E. Lauressergues et al., Signal transduction and functional selectivity of F15599, a preferential post-synaptic 5-HT1A receptor agonist, Br J Pharmacol, vol.156, pp.338-353, 2009.
DOI : 10.1111/j.1476-5381.2008.00001.x

URL : https://bpspubs.onlinelibrary.wiley.com/doi/pdf/10.1111/j.1476-5381.2008.00001.x

A. Newman-tancredi, J. C. Martel, C. Cosi, P. Heusler, F. Lestienne et al., Distinctive in vitro signal transduction profile of NLX-112, a potent and efficacious serotonin 5-HT1A receptor agonist, J Pharm Pharmacol, vol.69, pp.1178-1190, 2017.

D. E. Nichols and C. D. Nichols, Serotonin receptors, Chem Rev, vol.108, pp.1614-1641, 2008.

Y. Nomura, Neurophysiology of Rett syndrome, Brain Dev, vol.23, issue.1, pp.50-57, 2001.

S. Offermanns, T. Wieland, D. Homann, J. Sandmann, E. Bombien et al., Transfected muscarinic acetylcholine receptors selectively couple to Gi-type G proteins and Gq/11, Mol Pharmacol, vol.45, pp.890-898, 1994.

S. Oleskevich, G alpha o1 decapeptide modulates the hippocampal 5-HT1A potassium current, J Neurophysiol, vol.74, pp.2189-2193, 1995.
DOI : 10.1152/jn.1995.74.5.2189

S. Oleskevich, L. Descarries, K. C. Watkins, P. Seguela, and A. Daszuta, Ultrastructural features of the serotonin innervation in adult rat hippocampus: an immunocytochemical description in single and serial thin sections, Neuroscience, vol.42, pp.777-791, 1991.

B. Olivier, W. Soudijn, and I. Van-wijngaarden, The 5-HT1A receptor and its ligands: structure and function, Prog Drug Res, vol.52, pp.103-165, 1999.
DOI : 10.1007/978-3-0348-8730-4_3

S. Osman, C. Lundkvist, V. W. Pike, C. Halldin, J. A. Mccarron et al., Characterization of the radioactive metabolites of the 5-HT1A receptor radioligand, [O-methyl11C]WAY-100635, in monkey and human plasma by CLHP: comparison of the behaviour of an identified radioactive metabolite with parent radioligand in monkey using PET, Nucl Med Biol, vol.23, pp.627-634, 1996.

M. Palchaudhuri and G. Flugge, 5-HT1A receptor expression in pyramidal neurons of cortical and limbic brain regions, Cell Tissue Res, vol.321, pp.159-172, 2005.

M. Palner, M. D. Underwood, D. J. Kumar, V. Arango, G. M. Knudsen et al., Ex vivo evaluation of the serotonin 1A receptor partial agonist, Synapse, vol.65, issue.3, pp.715-723, 2011.

C. L. Parks, P. S. Robinson, E. Sibille, T. Shenk, and M. Toth, Increased anxiety of mice lacking the serotonin1A receptor, Proc Natl Acad Sci U S A, vol.95, pp.10734-10739, 1998.

R. V. Parsey, V. Arango, D. M. Olvet, M. A. Oquendo, R. L. Van-heertum et al., Regional heterogeneity of 5-HT1A receptors in human cerebellum as assessed by positron emission tomography, J Cereb Blood Flow Metab, vol.25, pp.785-793, 2005.

R. V. Parsey, R. T. Ogden, J. M. Miller, A. Tin, N. Hesselgrave et al., Higher serotonin 1A binding in a second major depression cohort: modeling and reference region considerations, Biol Psychiatry, vol.68, pp.170-178, 2010.
DOI : 10.1016/j.biopsych.2010.03.023

URL : http://europepmc.org/articles/pmc2900398?pdf=render

J. Passchier, A. Gee, A. Willemsen, W. Vaalburg, and A. Van-waarde, Measuring drug-related receptor occupancy with positron emission tomography, Methods, vol.27, pp.278-286, 2002.
DOI : 10.1016/s1046-2023(02)00084-1

D. S. Paterson, F. L. Trachtenberg, E. G. Thompson, R. A. Belliveau, A. H. Beggs et al., Multiple serotonergic brainstem abnormalities in sudden infant death syndrome, JAMA, vol.296, pp.2124-2132, 2006.

L. M. Paterson, B. R. Kornum, D. J. Nutt, V. W. Pike, and G. M. Knudsen, 5-HT radioligands for human brain imaging with PET and SPECT, Med Res Rev, vol.33, pp.54-111, 2013.
DOI : 10.1002/med.20245

URL : http://europepmc.org/articles/pmc4188513?pdf=render

L. M. Paterson, R. J. Tyacke, D. J. Nutt, and G. M. Knudsen, Measuring endogenous 5-HT release by emission tomography: promises and pitfalls, J Cereb Blood Flow Metab, vol.30, pp.1682-1706, 2010.
DOI : 10.1038/jcbfm.2010.104

URL : http://journals.sagepub.com/doi/pdf/10.1038/jcbfm.2010.104

G. Paxinos and C. Watson, The rat brain in stereotaxic coordinates, 1986.

M. E. Phelps, S. C. Huang, E. J. Hoffman, C. Selin, L. Sokoloff et al., Tomographic measurement of local cerebral glucose metabolic rate in humans with (F-18)2-fluoro-2-deoxy-Dglucose: validation of method, Ann Neurol, vol.6, pp.371-388, 1979.

V. W. Pike, PET radiotracers: crossing the blood-brain barrier and surviving metabolism, Trends Pharmacol Sci, vol.30, pp.431-440, 2009.
DOI : 10.1016/j.tips.2009.05.005

URL : http://europepmc.org/articles/pmc2805092?pdf=render

V. W. Pike, J. A. Mccarron, A. A. Lammertsma, S. Osman, S. P. Hume et al., Exquisite delineation of 5-HT1A receptors in human brain with PET and, Eur J Pharmacol, vol.301, pp.5-7, 1996.

L. H. Pinborg, L. Feng, M. E. Haahr, N. Gillings, A. Dyssegaard et al., )C]CUMI-101 binding to 5-HT(1A) receptors after intravenous citalopram in human, Synapse, vol.66, issue.1, pp.880-884, 2012.
DOI : 10.1002/syn.21579

V. V. Pineda, J. I. Athos, H. Wang, J. Celver, D. Ippolito et al., Removal of G(ialpha1) constraints on adenylyl cyclase in the hippocampus enhances LTP and impairs memory formation, Neuron, vol.41, pp.153-163, 2004.

G. Pineyro and P. Blier, Autoregulation of serotonin neurons: role in antidepressant drug action, Pharmacol Rev, vol.51, pp.533-591, 1999.

A. Plenevaux, D. Weissmann, J. Aerts, C. Lemaire, C. Brihaye et al., ]MPPF), a new serotonin 5-HT(1A) antagonist for positron emission tomography: An In vivo study in rats, J Neurochem, vol.75, pp.803-811, 2000.

D. B. Plewes and W. Kucharczyk, Physics of MRI: a primer, J Magn Reson Imaging, vol.35, pp.1038-1054, 2012.

M. Politis and F. Niccolini, Serotonin in Parkinson's disease, Behav Brain Res, vol.277, pp.136-145, 2015.

M. Politis, K. Wu, C. Loane, D. J. Brooks, L. Kiferle et al., Serotonergic mechanisms responsible for levodopa-induced dyskinesias in Parkinson's disease patients, J Clin Invest, vol.124, pp.1340-1349, 2014.

A. M. Polter and X. Li, 5-HT1A receptor-regulated signal transduction pathways in brain, Cell Signal, vol.22, pp.1406-1412, 2010.

M. Pompeiano, J. M. Palacios, and G. Mengod, Distribution and cellular localization of mRNA coding for 5-HT1A receptor in the rat brain: correlation with receptor binding, J Neurosci, vol.12, pp.440-453, 1992.

N. Praschak-rieder, D. Hussey, A. A. Wilson, A. Carella, M. Lee et al., Tryptophan depletion and serotonin loss in selective serotonin reuptake inhibitor-treated depression: an [(18)F] MPPF positron emission tomography study, Biol Psychiatry, vol.56, pp.587-591, 2004.

M. A. Preece, M. J. Taylor, J. Raley, A. Blamire, T. Sharp et al., Evidence that increased 5-HT release evokes region-specific effects on blood-oxygenation level-dependent functional magnetic resonance imaging responses in the rat brain, Neuroscience, vol.159, pp.751-759, 2009.

T. J. Pucadyil and A. Chattopadhyay, The human serotonin1A receptor exhibits G-proteindependent cell surface dynamics, Glycoconj J, vol.24, pp.25-31, 2007.

Y. Qian, H. E. Melikian, D. B. Rye, A. I. Levey, and R. D. Blakely, Identification and characterization of antidepressant-sensitive serotonin transporter proteins using site-specific antibodies, J Neurosci, vol.15, pp.1261-1274, 1995.

A. Quiedeville, M. Boulouard, V. Da-silva-costa-aze, F. Dauphin, V. Bouet et al., 5-HT6 receptor antagonists as treatment for age-related cognitive decline, Rev Neurosci, vol.25, pp.417-427, 2014.

E. A. Rabiner, R. N. Gunn, M. R. Wilkins, E. Sedman, and P. M. Grasby, Evaluation of EMD 128 130 occupancy of the 5-HT1A and the D2 receptor: a human PET study with [11C]WAY-100635 and [11C]raclopride, J Psychopharmacol, vol.16, pp.195-199, 2002.

F. Radja, A. M. Laporte, G. Daval, D. Verge, H. Gozlan et al., Autoradiography of serotonin receptor subtypes in the central nervous system, Neurochem Int, vol.18, pp.1-15, 1991.

M. J. Ramirez, M. K. Lai, R. M. Tordera, and P. T. Francis, Serotonergic therapies for cognitive symptoms in Alzheimer's disease: rationale and current status, Drugs, vol.74, pp.729-736, 2014.

M. M. Rapport, Serum vasoconstrictor (serotonin) the presence of creatinine in the complex; a proposed structure of the vasoconstrictor principle, J Biol Chem, vol.180, pp.961-969, 1949.

M. M. Rapport, A. A. Green, and I. H. Page, Crystalline Serotonin. Science, vol.108, pp.329-330, 1948.

J. Raskin, J. Cummings, J. Hardy, K. Schuh, and R. A. Dean, Neurobiology of Alzheimer's Disease: Integrated Molecular, Physiological, Anatomical, Biomarker, and Cognitive Dimensions, Curr Alzheimer Res, vol.12, pp.712-722, 2015.

S. G. Rasmussen, H. J. Choi, J. J. Fung, E. Pardon, P. Casarosa et al., Nature, vol.469, pp.175-180, 2011.

S. G. Rasmussen, B. T. Devree, Y. Zou, A. C. Kruse, K. Y. Chung et al., Nature, vol.477, pp.549-555, 2011.

J. R. Raymond, Y. V. Mukhin, A. Gelasco, J. Turner, G. Collinsworth et al., Multiplicity of mechanisms of serotonin receptor signal transduction, Pharmacol Ther, vol.92, pp.179-212, 2001.

F. Razoux, C. Baltes, T. Mueggler, A. Seuwen, H. Russig et al., Functional MRI to assess alterations of functional networks in response to pharmacological or genetic manipulations of the serotonergic system in mice, Neuroimage, vol.74, pp.326-336, 2013.

J. Ren, X. Ding, and J. J. Greer, 5-HT1A receptor agonist Befiradol reduces fentanyl-induced respiratory depression, analgesia, and sedation in rats, Anesthesiology, vol.122, pp.424-434, 2015.

M. Riad, S. Garcia, K. C. Watkins, N. Jodoin, E. Doucet et al., Somatodendritic localization of 5-HT1A and preterminal axonal localization of 5HT1B serotonin receptors in adult rat brain, J Comp Neurol, vol.417, pp.181-194, 2000.

J. W. Richardson-jones, C. P. Craige, B. P. Guiard, A. Stephen, K. L. Metzger et al., 5-HT1A autoreceptor levels determine vulnerability to stress and response to antidepressants, Neuron, vol.65, pp.40-52, 2010.

G. B. Richerson, Serotonergic neurons as carbon dioxide sensors that maintain pH homeostasis, Nat Rev Neurosci, vol.5, pp.449-461, 2004.

J. J. Rodriguez, H. N. Noristani, and A. Verkhratsky, The serotonergic system in ageing and Alzheimer's disease, Prog Neurobiol, vol.99, pp.15-41, 2012.

T. Rohlfing, C. D. Kroenke, E. V. Sullivan, M. F. Dubach, D. M. Bowden et al., The INIA19 Template and NeuroMaps Atlas for Primate Brain Image Parcellation and Spatial Normalization, p.27, 2012.

J. C. Roux and L. Villard, Biogenic amines in Rett syndrome: the usual suspects, Behav Genet, vol.40, pp.59-75, 2010.

V. P. Sah, T. M. Seasholtz, S. A. Sagi, and J. H. Brown, The role of Rho in G protein-coupled receptor signal transduction, Annu Rev Pharmacol Toxicol, vol.40, pp.459-489, 2000.

M. Sakaue, P. Somboonthum, B. Nishihara, Y. Koyama, H. Hashimoto et al., Postsynaptic 5-hydroxytryptamine(1A) receptor activation increases in vivo dopamine release in rat prefrontal cortex, Br J Pharmacol, vol.129, pp.1028-1034, 2000.

S. A. Sakowski, T. J. Geddes, D. M. Thomas, E. Levi, J. S. Hatfield et al., Differential tissue distribution of tryptophan hydroxylase isoforms 1 and 2 as revealed with monospecific antibodies, Brain Res, vol.1085, pp.11-18, 2006.

E. Salmon, A review of the literature on neuroimaging of serotoninergic function in Alzheimer's disease and related disorders, J Neural Transm, vol.114, pp.1179-1185, 2007.

I. S. Samuels, S. C. Saitta, and G. E. Landreth, MAP'ing CNS development and cognition: an ERKsome process, Neuron, vol.61, pp.160-167, 2009.

C. Y. Sander, J. M. Hooker, C. Catana, M. D. Normandin, N. M. Alpert et al., Neurovascular coupling to D2/D3 dopamine receptor occupancy using simultaneous PET/functional MRI, Proc Natl Acad Sci U S A, vol.110, pp.11169-11174, 2013.

C. Y. Sander, J. M. Hooker, C. Catana, B. R. Rosen, and J. B. Mandeville, Imaging Agonist-Induced D2/D3 Receptor Desensitization and Internalization In vivo with PET/fMRI, Neuropsychopharmacology, vol.41, pp.1427-1436, 2016.

N. Santana, A. Bortolozzi, J. Serrats, G. Mengod, and F. Artigas, Expression of serotonin1A and serotonin2A receptors in pyramidal and GABAergic neurons of the rat prefrontal cortex, Cereb Cortex, vol.14, pp.1100-1109, 2004.

L. Santarelli, M. Saxe, C. Gross, A. Surget, F. Battaglia et al., Requirement of hippocampal neurogenesis for the behavioral effects of antidepressants, Science, vol.301, pp.805-809, 2003.

Z. Sarnyai, E. L. Sibille, C. Pavlides, R. J. Fenster, B. S. Mcewen et al., Impaired hippocampal-dependent learning and functional abnormalities in the hippocampus in mice lacking serotonin(1A) receptors, Proc Natl Acad Sci U S A, vol.97, pp.14731-14736, 2000.

S. Sato, K. Mizukami, and T. Asada, A preliminary open-label study of 5-HT1A partial agonist tandospirone for behavioural and psychological symptoms associated with dementia, Int J Neuropsychopharmacol, vol.10, pp.281-283, 2007.

A. Saulin, M. Savli, and R. Lanzenberger, Serotonin and molecular neuroimaging in humans using PET, Amino Acids, vol.42, pp.2039-2057, 2012.

J. Savitz, I. Lucki, and W. C. Drevets, 5-HT(1A) receptor function in major depressive disorder, Prog Neurobiol, vol.88, pp.17-31, 2009.

M. Savli, A. Bauer, M. Mitterhauser, Y. S. Ding, A. Hahn et al., Normative database of the serotonergic system in healthy subjects using multi-tracer PET, Neuroimage, vol.63, pp.447-459, 2012.

B. E. Scanley, R. P. Kennan, and J. C. Gore, Changes in rat cerebral blood volume due to modulation of the 5-HT(1A) receptor measured with susceptibility enhanced contrast MRI, Brain Res, vol.913, pp.149-155, 2001.

L. E. Schechter, D. L. Smith, S. Rosenzweig-lipson, S. J. Sukoff, L. A. Dawson et al., Lecozotan (SRA333): a selective serotonin 1A receptor antagonist that enhances the stimulated release of glutamate and acetylcholine in the hippocampus and possesses cognitive-enhancing properties, J Pharmacol Exp Ther, vol.314, pp.1274-1289, 2005.

D. Schmitz, R. M. Empson, and U. Heinemann, Serotonin reduces inhibition via 5-HT1A receptors in area CA1 of rat hippocampal slices in vitro, J Neurosci, vol.15, pp.7217-7225, 1995.

C. A. Schneider, W. S. Rasband, and K. W. Eliceiri, NIH Image to ImageJ: 25 years of image analysis, Nat Methods, vol.9, pp.671-675, 2012.

R. Schreiber and A. Newman-tancredi, Improving cognition in schizophrenia with antipsychotics that elicit neurogenesis through 5-HT(1A) receptor activation, Neurobiol Learn Mem, vol.110, pp.72-80, 2014.

A. J. Schwarz, A. Gozzi, T. Reese, and A. Bifone, In vivo mapping of functional connectivity in neurotransmitter systems using pharmacological MRI, Neuroimage, vol.34, pp.1627-1636, 2007.

P. Seeman, Atypical antipsychotics: mechanism of action, Can J Psychiatry, vol.47, pp.27-38, 2002.

P. Seeman and S. Kapur, Anesthetics inhibit high-affinity states of dopamine D2 and other Glinked receptors, Synapse, vol.50, pp.35-40, 2003.

S. Selvaraj, D. Arnone, A. Cappai, and O. Howes, Alterations in the serotonin system in schizophrenia: a systematic review and meta-analysis of postmortem and molecular imaging studies, Neurosci Biobehav Rev, vol.45, pp.233-245, 2014.

S. Selvaraj, F. Turkheimer, L. Rosso, P. Faulkner, E. Mouchlianitis et al., Measuring endogenous changes in serotonergic neurotransmission in humans: a [11C]CUMI-101 PET challenge study, Mol Psychiatry, vol.17, pp.1254-1260, 2012.

A. Serrano-pozo, M. P. Frosch, E. Masliah, and B. T. Hyman, Neuropathological alterations in Alzheimer disease, Cold Spring Harb Perspect Med, vol.1, p.6189, 2011.

T. Sharp, L. Boothman, J. Raley, and P. Queree, Important messages in the 'post': recent discoveries in 5-HT neurone feedback control, Trends Pharmacol Sci, vol.28, pp.629-636, 2007.

S. Shimizu and Y. Ohno, Improving the Treatment of Parkinson's Disease: A Novel Approach by Modulating 5-HT(1A) Receptors, Aging Dis, vol.4, pp.1-13, 2013.

S. Shimizu, A. Tatara, J. Imaki, and Y. Ohno, Role of cortical and striatal 5-HT1A receptors in alleviating antipsychotic-induced extrapyramidal disorders, Prog Neuropsychopharmacol Biol Psychiatry, vol.34, pp.877-881, 2010.

C. Y. Shiue, G. G. Shiue, P. D. Mozley, M. P. Kung, Z. P. Zhuang et al., , 1997.

, MPPF: a potential radioligand for PET studies of 5-HT1A receptors in humans, Synapse, vol.25, pp.147-154

S. Shrestha, J. Hirvonen, C. S. Hines, I. D. Henter, P. Svenningsson et al., Serotonin-1A receptors in major depression quantified using PET: controversies, confounds, and recommendations, Neuroimage, vol.59, pp.3243-3251, 2012.

S. S. Shrestha, J. S. Liow, K. Jenko, M. Ikawa, S. S. Zoghbi et al., The 5-HT1A Receptor PET Radioligand 11C-CUMI-101 Has Significant Binding to alpha1-Adrenoceptors in Human Cerebellum, Limiting Its Use as a Reference Region, J Nucl Med, vol.57, pp.1945-1948, 2016.

S. S. Shrestha, J. S. Liow, S. Lu, K. Jenko, R. L. Gladding et al., )C-CUMI-101, a PET radioligand, behaves as a serotonin 1A receptor antagonist and also binds to alpha(1) adrenoceptors in brain, J Nucl Med, vol.55, issue.11, pp.141-146, 2014.

B. Y. Silber and J. A. Schmitt, Effects of tryptophan loading on human cognition, mood, and sleep, Neurosci Biobehav Rev, vol.34, pp.387-407, 2010.

M. Skinbjerg, D. R. Sibley, J. A. Javitch, and A. Abi-dargham, Imaging the high-affinity state of the dopamine D2 receptor in vivo: fact or fiction?, Biochem Pharmacol, vol.83, pp.193-198, 2012.

P. Slater, C. A. Doyle, and J. F. Deakin, Abnormal persistence of cerebellar serotonin-1A receptors in schizophrenia suggests failure to regress in neonates, J Neural Transm, vol.105, issue.Vienna, pp.305-315, 1998.

C. Sotelo, B. Cholley, S. El-mestikawy, H. Gozlan, and M. Hamon, Direct Immunohistochemical Evidence of the Existence of 5-HT1A Autoreceptors on Serotoninergic Neurons in the Midbrain Raphe Nuclei, Eur J Neurosci, vol.2, pp.1144-1154, 1990.

M. Spies, G. M. Knudsen, R. Lanzenberger, and S. Kasper, The serotonin transporter in psychiatric disorders: insights from PET imaging, Lancet Psychiatry, vol.2, pp.743-755, 2015.

J. Sprouse, L. Reynolds, X. Li, J. Braselton, and A. Schmidt, 8-OH-DPAT as a 5-HT7 agonist: phase shifts of the circadian biological clock through increases in cAMP production, Neuropharmacology, vol.46, pp.52-62, 2004.

J. S. Sprouse and G. K. Aghajanian, Electrophysiological responses of serotoninergic dorsal raphe neurons to 5-HT1A and 5-HT1B agonists, Synapse, vol.1, pp.3-9, 1987.

J. S. Sprouse and G. K. Aghajanian, Responses of hippocampal pyramidal cells to putative serotonin 5-HT1A and 5-HT1B agonists: a comparative study with dorsal raphe neurons, Neuropharmacology, vol.27, pp.707-715, 1988.

S. M. Stahl, B. Sommer, and K. A. Allers, Multifunctional pharmacology of flibanserin: possible mechanism of therapeutic action in hypoactive sexual desire disorder, J Sex Med, vol.8, pp.15-27, 2011.

J. A. Stark, K. E. Davies, S. R. Williams, and S. M. Luckman, Functional magnetic resonance imaging and c-Fos mapping in rats following an anorectic dose of m-chlorophenylpiperazine, Neuroimage, vol.31, pp.1228-1237, 2006.

R. P. Stephenson, A modification of receptor theory, Br J Pharmacol Chemother, vol.11, pp.379-393, 1956.

C. A. Steward, C. A. Marsden, M. J. Prior, P. G. Morris, and Y. B. Shah, Methodological considerations in rat brain BOLD contrast pharmacological MRI, Psychopharmacology (Berl), vol.180, pp.687-704, 2005.

A. Stewart, J. Huang, and R. Fisher, RGS Proteins in heart: Brakes on the Vagus, Front Physiol, vol.3, p.95, 2012.

M. Suehiro, M. Underwood, V. Arango, T. S. Wang, S. Kassir et al., In vivo biodistribution of a radiotracer for imaging serotonin-1A receptor sites with PET:[11C]LY274601, Life Sci, vol.63, pp.1533-1542, 1998.

N. R. Sullivan, J. W. Crane, K. J. Damjanoska, G. A. Carrasco, D. N. Souza et al., Tandospirone activates neuroendocrine and ERK (MAP kinase) signaling pathways specifically through 5-HT1A receptor mechanisms in vivo, Naunyn Schmiedebergs Arch Pharmacol, vol.371, pp.18-26, 2005.

A. C. Sutton, K. A. O'connor, J. G. Pilitsis, and D. S. Shin, Stimulation of the subthalamic nucleus engages the cerebellum for motor function in parkinsonian rats, Brain Struct Funct, vol.220, pp.3595-3609, 2015.

G. Swaminath, Y. Xiang, T. W. Lee, J. Steenhuis, C. Parnot et al., Sequential binding of agonists to the beta2 adrenoceptor. Kinetic evidence for intermediate conformational states, J Biol Chem, vol.279, pp.686-691, 2004.

J. D. Sweatt, Mitogen-activated protein kinases in synaptic plasticity and memory, Curr Opin Neurobiol, vol.14, pp.311-317, 2004.

K. Tada, K. Kasamo, T. Suzuki, Y. Matsuzaki, and T. Kojima, Endogenous 5-HT inhibits firing activity of hippocampal CA1 pyramidal neurons during conditioned fear stress-induced freezing behavior through stimulating 5-HT1A receptors, Hippocampus, vol.14, pp.143-147, 2004.

M. Tahmasian, L. Pasquini, M. Scherr, C. Meng, S. Forster et al., The lower hippocampus global connectivity, the higher its local metabolism in Alzheimer disease, Neurology, vol.84, pp.1956-1963, 2015.

D. Tampellini, Synaptic activity and Alzheimer's disease: a critical update, Front Neurosci, vol.9, p.423, 2015.

A. Tavares, G. Becker, O. Barret, T. Morley, D. Alagille et al., , 2013.

A. Thathiah and B. De-strooper, The role of G protein-coupled receptors in the pathology of Alzheimer's disease, Nat Rev Neurosci, vol.12, pp.73-87, 2011.

J. O. Thorell, M. H. Hedberg, A. M. Johansson, U. Hacksell, S. Stone-elander et al., Ingvar, M, 1995. (R)-[N-11C-methyl]-11-hydroxy-10-methylaporphine as a ligand for 5-HT1A receptors: synthesis and evaluation of its biodistribution in monkey with PET, J Label Compd Radiopharm, vol.44, p.179

D. N. Tipre, S. S. Zoghbi, J. S. Liow, M. V. Green, J. Seidel et al., PET imaging of brain 5-HT1A receptors in rat in vivo with 18F-FCWAY and improvement by successful inhibition of radioligand defluorination with miconazole, J Nucl Med, vol.47, pp.345-353, 2006.

M. Toda and A. Abi-dargham, Dopamine hypothesis of schizophrenia: making sense of it all, Curr Psychiatry Rep, vol.9, pp.329-336, 2007.

M. Tomiyama, T. Kimura, T. Maeda, K. Kannari, M. Matsunaga et al., A serotonin 5HT1A receptor agonist prevents behavioral sensitization to L-DOPA in a rodent model of Parkinson's disease, Neurosci Res, vol.52, pp.185-194, 2005.

I. Tork, Anatomy of the serotonergic system, Ann N Y Acad Sci, vol.600, pp.9-34, 1990.

L. Truchot, N. Costes, L. Zimmer, B. Laurent, D. Le-bars et al., A distinct [18F]MPPF PET profile in amnestic mild cognitive impairment compared to mild Alzheimer's disease, Neuroimage, vol.40, pp.1251-1256, 2008.

L. Truchot, S. N. Costes, L. Zimmer, B. Laurent, D. Le-bars et al., Up-regulation of hippocampal serotonin metabolism in mild cognitive impairment, Neurology, vol.69, pp.1012-1017, 2007.
URL : https://hal.archives-ouvertes.fr/hal-00443482

B. M. Twarog and I. H. Page, Serotonin content of some mammalian tissues and urine and a method for its determination, Am J Physiol, vol.175, pp.157-161, 1953.

R. J. Tyacke and D. J. Nutt, Optimising PET approaches to measuring 5-HT release in human brain, Synapse, vol.69, pp.505-511, 2015.

J. I. Udo-de-haes, F. J. Bosker, A. Van-waarde, J. Pruim, A. T. Willemsen et al., 5-HT(1A) receptor imaging in the human brain: effect of tryptophan depletion and infusion on [(18)F]MPPF binding, Synapse, vol.46, pp.108-115, 2002.

J. I. Udo-de-haes, T. I. Cremers, F. J. Bosker, F. Postema, T. D. Tiemersma-wegman et al., Effect of increased serotonin levels on [18F]MPPF binding in rat brain: fenfluramine vs the combination of citalopram and ketanserin, Neuropsychopharmacology, vol.30, pp.1624-1631, 2005.

J. I. Udo-de-haes, N. Harada, P. H. Elsinga, R. P. Maguire, and H. Tsukada, Effect of fenfluramineinduced increases in serotonin release on [18F]MPPF binding: a continuous infusion PET study in conscious monkeys, Synapse, vol.59, pp.18-26, 2006.

E. M. Valdizan, E. Castro, and A. Pazos, Agonist-dependent modulation of G-protein coupling and transduction of 5-HT1A receptors in rat dorsal raphe nucleus, Int J Neuropsychopharmacol, vol.13, pp.835-843, 2010.

M. Vandecapelle, F. Dumont, F. De-vos, K. Strijckmans, D. Leysen et al., Synthesis and preliminaryin vivo evaluation of 4-[18F]fluoro-N-{2-[4-(6trifluoromethylpyridin-2-yl)piperazin-1-yl]ethyl}benzamide, a potential PET radioligand for the 5HT1A receptor, J Label Compd Radiopharm, vol.47, pp.531-542, 2004.

I. Van-der-ploeg, A. Cintra, N. Altiok, P. Askelof, K. Fuxe et al., Limited distribution of pertussis toxin in rat brain after injection into the lateral cerebral ventricles, Neuroscience, vol.44, pp.205-214, 1991.

N. P. Van-goethem, R. Schreiber, A. Newman-tancredi, M. Varney, and J. Prickaerts, Divergent effects of the 'biased' 5-HT1 A receptor agonists F15599 and F13714 in a novel object pattern separation task, Br J Pharmacol, vol.172, pp.2532-2543, 2015.

V. Varga, A. D. Szekely, A. Csillag, T. Sharp, and M. Hajos, Evidence for a role of GABA interneurones in the cortical modulation of midbrain 5-hydroxytryptamine neurones, Neuroscience, vol.106, pp.783-792, 2001.

M. Verdurand, A. Berod, D. Le-bars, and L. Zimmer, Effects of amyloid-beta peptides on the serotoninergic 5-HT1A receptors in the rat hippocampus, Neurobiol Aging, vol.32, pp.103-114, 2011.
URL : https://hal.archives-ouvertes.fr/hal-00397792

M. Verdurand, F. Chauveau, A. Daoust, A. L. Morel, F. Bonnefoi et al., Differential effects of amyloid-beta 1-40 and 1-42 fibrils on 5-HT1A serotonin receptors in rat brain, Neurobiol Aging, vol.40, pp.11-21, 2016.
URL : https://hal.archives-ouvertes.fr/hal-01291764

M. Verdurand and L. Zimmer, Hippocampal 5-HT1A receptor expression changes in prodromal stages of Alzheimer's disease: Beneficial or deleterious?, Neuropharmacology, vol.123, pp.446-454, 2017.

D. Verge, G. Daval, A. Patey, H. Gozlan, S. El-mestikawy et al., Presynaptic 5-HT autoreceptors on serotonergic cell bodies and/or dendrites but not terminals are of the 5-HT1A subtype, Eur J Pharmacol, vol.113, pp.463-464, 1985.

B. Vidal, J. Sebti, M. Verdurand, S. Fieux, T. Billard et al., Agonist and antagonist bind differently to 5-HT1A receptors during Alzheimer's disease: A post-mortem study with PET radiopharmaceuticals, Neuropharmacology, vol.109, pp.88-95, 2016.

A. K. Visser, A. Van-waarde, A. T. Willemsen, F. J. Bosker, P. G. Luiten et al., Measuring serotonin synthesis: from conventional methods to PET tracers and their (pre)clinical implications, Eur J Nucl Med Mol Imaging, vol.38, pp.576-591, 2011.

N. D. Volkow, J. S. Fowler, G. J. Wang, R. Baler, and F. Telang, Imaging dopamine's role in drug abuse and addiction, Neuropharmacology, vol.56, pp.3-8, 2009.

D. J. Walther and M. Bader, A unique central tryptophan hydroxylase isoform, Biochem Pharmacol, vol.66, pp.1673-1680, 2003.

B. D. Waterhouse, G. A. Mihailoff, J. C. Baack, and D. J. Woodward, Topographical distribution of dorsal and median raphe neurons projecting to motor, sensorimotor, and visual cortical areas in the rat, J Comp Neurol, vol.249, pp.478-481, 1986.

J. Watson, L. Collin, M. Ho, G. Riley, C. Scott et al., 5-HT(1A) receptor agonist-antagonist binding affinity difference as a measure of intrinsic activity in recombinant and native tissue systems, Br J Pharmacol, vol.130, pp.1108-1114, 2000.

K. Wedzony, M. Mackowiak, A. Czyrak, K. Fijal, and B. Michalska, Single doses of MK-801, a noncompetitive antagonist of NMDA receptors, increase the number of 5-HT1A serotonin receptors in the rat brain, Brain Res, vol.756, pp.84-91, 1997.

H. F. Wehrl, M. Hossain, K. Lankes, C. C. Liu, I. Bezrukov et al., Simultaneous PET-MRI reveals brain function in activated and resting state on metabolic, hemodynamic and multiple temporal scales, Nat Med, vol.19, pp.1184-1189, 2013.

D. Weinstein, D. Magnuson, and J. Lee, , 1996.

, N-dipropyl-2-aminotetralin serotonergic binding site in Alzheimer's disease, Behav Brain Res, vol.73, pp.325-329

H. Y. Wey, C. Catana, J. M. Hooker, D. D. Dougherty, G. M. Knudsen et al., Simultaneous fMRI-PET of the opioidergic pain system in human brain, Neuroimage, vol.102, pp.275-282, 2014.

P. M. Whitaker-azmitia, C. Clarke, and E. C. Azmitia, Localization of 5-HT1A receptors to astroglial cells in adult rats: implications for neuronal-glial interactions and psychoactive drug mechanism of action, Synapse, vol.14, pp.201-205, 1993.

L. Wiklund, L. Leger, and M. Persson, Monoamine cell distribution in the cat brain stem. A fluorescence histochemical study with quantification of indolaminergic and locus coeruleus cell groups, J Comp Neurol, vol.203, pp.613-647, 1981.

T. Wurch, F. C. Colpaert, and P. J. Pauwels, Mutation in a protein kinase C phosphorylation site of the 5-HT1A receptor preferentially attenuates Ca2+ responses to partial as opposed to higherefficacy 5-HT1A agonists, Neuropharmacology, vol.44, pp.873-881, 2003.

Z. Xu, G. P. Reynolds, Y. Yuan, Y. Shi, M. Pu et al., TPH-2 Polymorphisms Interact with Early Life Stress to Influence Response to Treatment with Antidepressant Drugs, Int J Neuropsychopharmacol, 2016.

F. Yan, P. D. Mosier, R. B. Westkaemper, and B. L. Roth, Galpha-subunits differentially alter the conformation and agonist affinity of kappa-opioid receptors, Biochemistry, vol.47, pp.1567-1578, 2008.

X. Yao, C. Parnot, X. Deupi, V. R. Ratnala, G. Swaminath et al., Coupling ligand structure to specific conformational switches in the beta2-adrenoceptor, Nat Chem Biol, vol.2, pp.417-422, 2006.

C. Yokoyama, A. Mawatari, A. Kawasaki, C. Takeda, K. Onoe et al., Marmoset Serotonin 5-HT1A Receptor Mapping with a Biased Agonist PET Probe 18F-F13714: Comparison with an Antagonist Tracer 18F-MPPF in Awake and Anesthetized States, Int J Neuropsychopharmacol, 2016.
URL : https://hal.archives-ouvertes.fr/hal-01488155

K. Zhang, Y. Zhu, Y. Zhu, S. Wu, H. Liu et al., Molecular, Functional, and Structural Imaging of Major Depressive Disorder, Neurosci Bull, vol.32, pp.273-285, 2016.

X. Zhang, J. M. Beaulieu, R. R. Gainetdinov, and M. G. Caron, Functional polymorphisms of the brain serotonin synthesizing enzyme tryptophan hydroxylase-2, Cell Mol Life Sci, vol.63, pp.6-11, 2006.

L. Zhou and L. M. Bohn, Functional selectivity of GPCR signaling in animals, Curr Opin Cell Biol, vol.27, pp.102-108, 2014.

L. Zimmer, G. Fournet, J. Benoit, G. Guillaumet, and D. Le-bars, Carbon-11 labelling of 8, 2003.

C. , thiochroman, a presynaptic 5-HT(1A) receptor agonist, and its in vivo evaluation in anaesthetised rat and in awake cat, Nucl Med Biol, vol.30, pp.541-546

L. Zimmer and D. Le-bars, Current status of positron emission tomography radiotracers for serotonin receptors in humans, J Labelled Comp Radiopharm, vol.56, pp.105-113, 2013.
URL : https://hal.archives-ouvertes.fr/hal-00828326

L. Zimmer and A. Luxen, PET radiotracers for molecular imaging in the brain: past, present and future, Neuroimage, vol.61, pp.363-370, 2012.
URL : https://hal.archives-ouvertes.fr/hal-00821153

L. Zimmer, A. Luxen, F. Giacomelli, and J. F. Pujol, Short-and long-term effects of pethynylphenylalanine on brain serotonin levels, Neurochem Res, vol.27, pp.269-275, 2002.

L. Zimmer, G. Mauger, D. Le-bars, G. Bonmarchand, A. Luxen et al., Effect of endogenous serotonin on the binding of the 5-hT1A PET ligand 18F-MPPF in the rat hippocampus: kinetic beta measurements combined with microdialysis, J Neurochem, vol.80, pp.278-286, 2002.