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Zebrafish left-right organizer : multi-scale analysis of cilia behaviors and flow-sensing mechanism for symmetry-breaking

Abstract : Both motile and immotile cilia play important roles in left-right (LR) axis determination, which generally involves cilia-mediated directional flows in organized structures (LR organizers, LRO) in which the LR symmetry is broken, thus driving asymmetric organogenesis in the developing embryos. In my PhD project we aimed to developed a method (3D-Cilia Map) and analyze the three-dimensional organization of ciliary implantation in order to extract the key parameters modulating the directional flow involved in breaking the axis of symmetry in the zebra fish LRO. Altogether, our results suggest the initial mechanism to break the LR symmetry is most likely to be based on the transport of achemical signal, while later, cells intrinsically provide their cilia the cues to orient asymmetrically. The work presented here represents an important contribution to our current understanding of cilia behaviors and flow-sensing mechanisms in the establishment of the left-right axis in the zebra fish LRO.
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Submitted on : Tuesday, October 2, 2018 - 12:31:12 PM
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Rita Rua Ferreira. Zebrafish left-right organizer : multi-scale analysis of cilia behaviors and flow-sensing mechanism for symmetry-breaking. Development Biology. Université de Strasbourg, 2017. English. ⟨NNT : 2017STRAJ001⟩. ⟨tel-01885819⟩

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