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Synthèse de nano-vecteurs dérivés des polydiacétylènes pour la co-délivrance d’un ARN interférent et d’un anticancéreux

Abstract : In the nanomedecine field, a new approach consists in developing synthetic vectors able to co-deliver into a cancer cell, an antitumoral drug and siRNAs that target protein(s) involved in MDR. The work described in this manuscript was dedicated to the development of micellar nanovectors for the intracellular co-delivery of these two therapeutic agents. The first part details the synthesis and the formulation of nanometric photopolymerized diacetylenic micelles adapted for the delivery and intracellular release of the siRNA. Then, the encapsulation and delivery properties of these micelles, bearing histidine polar heads have been investigated in vitro and in vivo for the application of combination therapy. Finally, the last part presents the functionalization by electrostatic interaction of these cationic vectors with antibodies, priorly modified by anionic oligonucleotides. This original and versatile system allowed achieving an active targeting of tumoral cells.
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https://tel.archives-ouvertes.fr/tel-01881814
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Submitted on : Wednesday, September 26, 2018 - 1:07:10 PM
Last modification on : Thursday, September 27, 2018 - 1:18:52 AM
Long-term archiving on: : Thursday, December 27, 2018 - 1:33:08 PM

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  • HAL Id : tel-01881814, version 1

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Manon Ripoll. Synthèse de nano-vecteurs dérivés des polydiacétylènes pour la co-délivrance d’un ARN interférent et d’un anticancéreux. Autre. Université de Strasbourg, 2017. Français. ⟨NNT : 2017STRAF076⟩. ⟨tel-01881814⟩

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