B. B. Aggarwal, Signalling pathways of the TNF superfamily: a double-edged sword, Nat. Rev. Immunol, vol.3, pp.745-756, 2003.

C. Akekawatchai, J. D. Holland, M. Kochetkova, J. C. Wallace, and S. R. Mccoll, , 2005.

, Transactivation of CXCR4 by the insulin-like growth factor-1 receptor (IGF-1R) in human MDA-MB-231 breast cancer epithelial cells, J. Biol. Chem, vol.280, pp.39701-39708

H. Akil, A. Perraud, C. Mélin, M. Jauberteau, and M. Mathonnet, Fine-tuning roles of endogenous brain-derived neurotrophic factor, TrkB and sortilin in colorectal cancer cell survival, PloS One, vol.6, 2011.
URL : https://hal.archives-ouvertes.fr/hal-00873136

H. Akter, M. Park, O. Kwon, E. J. Song, W. Park et al., Activation of matrix metalloproteinase-9 (MMP-9) by neurotensin promotes cell invasion and migration through ERK pathway in gastric cancer, Tumour Biol. J. Int. Soc. Oncodevelopmental Biol. Med, vol.36, pp.6053-6062, 2015.

M. J. Alexander, M. A. Miller, D. M. Dorsa, B. P. Bullock, R. H. Melloni et al., Distribution of neurotensin/neuromedin N mRNA in rat forebrain: unexpected abundance in hippocampus and subiculum, Proc. Natl. Acad. Sci. U. S. A, vol.86, pp.5202-5206, 1989.

M. Alifano, F. Souazé, S. Dupouy, S. Camilleri-broët, M. Younes et al., Neurotensin receptor 1 determines the outcome of non-small cell lung cancer, Clin. Cancer Res. Off. J. Am. Assoc. Cancer Res, vol.16, pp.4401-4410, 2010.

J. Allen, F. Khwaja, S. Byers, and D. Djakiew, The p75NTR mediates a bifurcated signal transduction cascade through the NF kappa B and JNK pathways to inhibit cell survival, Exp. Cell Res, vol.304, pp.69-80, 2005.

R. D. Almeida and C. B. Duarte, p75NTR Processing and Signaling: Functional Role, Handbook of Neurotoxicity, R.M. Kostrzewa, pp.1899-1923, 2014.

J. Almenoff, S. Wilk, and M. Orlowski, Membrane bound pituitary metalloendopeptidase: apparent identity to enkephalinase, Biochem. Biophys. Res. Commun, vol.102, pp.206-214, 1981.

S. Amar, J. Mazella, F. Checler, P. Kitabgi, and J. P. Vincent, Regulation of cyclic GMP levels by neurotensin in neuroblastoma clone N1E115, Biochem. Biophys. Res. Commun, vol.129, pp.117-125, 1985.

S. Amar, P. Kitabgi, and J. P. Vincent, Stimulation of inositol phosphate production by neurotensin in neuroblastoma N1E115 cells: implication of GTP-binding proteins and relationship with the cyclic GMP response, J. Neurochem, vol.49, pp.999-1006, 1987.

C. I. Amaya-chanaga and L. Z. Rassenti, Biomarkers in chronic lymphocytic leukemia: Clinical applications and prognostic markers, Best Pract. Res. Clin. Haematol, vol.29, pp.79-89, 2016.

A. M. Al-ameri, X. Badoux, A. Ferrajoli, W. G. Wierda, L. Fayad et al.,

M. J. Keating and S. Brien, Phase II Study of Dasatinib In Patients with Relapsed Chronic Lymphocytic Leukemia, Blood, vol.116, pp.4488-4488, 2010.

G. P. Amorino, P. D. Deeble, and S. J. Parsons, Neurotensin stimulates mitogenesis of prostate cancer cells through a novel c-Src/Stat5b pathway, Oncogene, vol.26, pp.745-756, 2007.

E. J. Anaissie, D. P. Kontoyiannis, S. O'brien, H. Kantarjian, L. Robertson et al., Infections in patients with chronic lymphocytic leukemia treated with fludarabine, Ann. Intern. Med, vol.129, pp.559-566, 1998.

J. C. Arévalo and S. H. Wu, Neurotrophin signaling: many exciting surprises!, Cell. Mol. Life Sci. CMLS, vol.63, pp.1523-1537, 2006.

J. C. Arevalo, B. Conde, B. L. Hempstead, M. V. Chao, D. Martin-zanca et al., TrkA immunoglobulin-like ligand binding domains inhibit spontaneous activation of the receptor, Mol. Cell. Biol, vol.20, pp.5908-5916, 2000.

J. C. Arevalo, B. Conde, B. I. Hempstead, M. V. Chao, D. Martín-zanca et al., A novel mutation within the extracellular domain of TrkA causes constitutive receptor activation, Oncogene, vol.20, pp.1229-1234, 2001.

J. C. Arévalo, H. Yano, K. K. Teng, and M. V. Chao, A unique pathway for sustained neurotrophin signaling through an ankyrin-rich membrane-spanning protein, EMBO J, vol.23, pp.2358-2368, 2004.

A. Armugam, D. C. Koh, C. S. Ching, K. Chandrasekaran, P. Kaur et al., Pro-domain in precursor nerve growth factor mediates cell death, Neurochem. Int, vol.60, pp.852-863, 2012.

F. Arruga and S. Deaglio, Mechanisms of Resistance to Targeted Therapies in Chronic Lymphocytic Leukemia, Handb. Exp. Pharmacol, 2017.

Y. Atoji, Y. Yamamoto, and Y. Suzuki, Neurotensin-containing endocrine cells and neurotensin receptor mRNA-expressing epithelial cells in the chicken thymus, Arch. Histol. Cytol, vol.59, pp.197-203, 1996.

J. K. Atwal, B. Massie, F. D. Miller, and D. R. Kaplan, The TrkB-Shc site signals neuronal survival and local axon growth via MEK and P13-kinase, Neuron, vol.27, pp.265-277, 2000.

V. Audrito, T. Vaisitti, S. Serra, C. Bologna, D. Brusa et al., Targeting the microenvironment in chronic lymphocytic leukemia offers novel therapeutic options, Cancer Lett, vol.328, pp.27-35, 2013.

T. Aurran-schleinitz, C. Arnoulet, V. Ivanov, D. Coso, J. Rey et al., , 2008.

, Rev. Med. Interne, vol.29, pp.424-435

B. Austen, A. Skowronska, C. Baker, J. E. Powell, A. Gardiner et al., Mutation status of the residual ATM allele is an important determinant of the cellular response to chemotherapy and survival in patients with chronic lymphocytic leukemia containing an 11q deletion, J. Clin. Oncol. Off. J. Am. Soc. Clin. Oncol, vol.25, pp.5448-5457, 2007.

I. Van-der-auwera, W. Yu, L. Suo, L. Van-neste, P. Van-dam et al., Array-based DNA methylation profiling for breast cancer subtype discrimination, PloS One, vol.5, 2010.

A. M. Avalos, F. Meyer-wentrup, and H. L. Ploegh, B-cell receptor signaling in lymphoid malignancies and autoimmunity, Adv. Immunol, vol.123, pp.1-49, 2014.

H. Avet-loiseau, J. Y. Li, T. Facon, C. Brigaudeau, N. Morineau et al., High incidence of translocations t(11;14)(q13;q32) and t(4;14)(p16;q32) in patients with plasma cell malignancies, Cancer Res, vol.58, pp.5640-5645, 1998.

A. E. Ayala-sarmiento, D. Martinez-fong, and J. Segovia, The Internalization of Neurotensin by the Low-Affinity Neurotensin Receptors (NTSR2 and vNTSR2) Activates ERK 1/2 in Glioma Cells and Allows Neurotensin-Polyplex Transfection of tGAS1, Cell. Mol. Neurobiol, vol.35, pp.785-795, 2015.

B. Bai, X. Cai, Y. Jiang, E. Karteris, C. et al., Heterodimerization of apelin receptor and neurotensin receptor 1 induces phosphorylation of ERK(1/2) and cell proliferation via G?q-mediated mechanism, J. Cell. Mol. Med, vol.18, pp.2071-2081, 2014.

K. Bakirtzi, M. Hatziapostolou, I. Karagiannides, C. Polytarchou, S. Jaeger et al., Neurotensin signaling activates microRNAs-21 and-155 and Akt, promotes tumor growth in mice, and is increased in human colon tumors, Gastroenterology, vol.141, pp.1749-1761, 2011.

K. Balakrishnan, J. A. Burger, W. G. Wierda, and V. Gandhi, AT-101 induces apoptosis in CLL B cells and overcomes stromal cell-mediated Mcl-1 induction and drug resistance, Blood, vol.113, pp.149-153, 2009.

Y. A. Barde, D. Edgar, and H. Thoenen, Purification of a new neurotrophic factor from mammalian brain, EMBO J, vol.1, pp.549-553, 1982.

H. Barelli, Y. K. Mao, B. Vincent, E. E. Daniel, J. P. Vincent et al., , 1993.

, Differential catabolic fate of neuromedin N and neurotensin in the canine intestinal mucosa, Peptides, vol.14, pp.457-463

H. Barelli, J. E. Fox-threlkeld, V. Dive, E. E. Daniel, J. P. Vincent et al., , 1994.

, 24.16 in the catabolism of neurotensin, in vivo, in the vascularly perfused dog ileum, Br. J. Pharmacol, vol.112, pp.127-132

P. A. Barker, Whither proBDNF?, Nat. Neurosci, vol.12, pp.105-106, 2009.

P. A. Barker, C. Lomen-hoerth, E. M. Gensch, S. O. Meakin, D. J. Glass et al., Tissue-specific alternative splicing generates two isoforms of the trkA receptor, J. Biol. Chem, vol.268, pp.15150-15157, 1993.

P. A. Barker, G. Barbee, T. P. Misko, and E. M. Shooter, The low affinity neurotrophin receptor, p75LNTR, is palmitoylated by thioester formation through cysteine 279, J. Biol. Chem, vol.269, pp.30645-30650, 1994.

M. Barragán, B. Bellosillo, C. Campàs, D. Colomer, G. Pons et al., Involvement of protein kinase C and phosphatidylinositol 3-kinase pathways in the survival of B-cell chronic lymphocytic leukemia cells, Blood, vol.99, pp.2969-2976, 2002.

J. C. Barrientos, Sequencing of chronic lymphocytic leukemia therapies, Hematol. Am. Soc. Hematol. Educ. Program, pp.128-136, 2016.

T. Baumann, J. Delgado, R. Santacruz, A. Martínez-trillos, C. Royo et al., Chronic lymphocytic leukemia in the elderly: clinico-biological features, outcomes, and proposal of a prognostic model, Haematologica, vol.99, pp.1599-1604, 2014.

I. R. Baxendale, S. Cheung, M. O. Kitching, S. V. Ley, and J. W. Shearman, The synthesis of neurotensin antagonist SR 48692 for prostate cancer research, Bioorg. Med. Chem, vol.21, pp.4378-4387, 2013.

A. Bayas, N. Kruse, N. F. Moriabadi, F. Weber, V. Hummel et al., Modulation of cytokine mRNA expression by brainderived neurotrophic factor and nerve growth factor in human immune cells, Neurosci. Lett, vol.335, pp.155-158, 2003.

A. J. Bean, A. Dagerlind, T. Hökfelt, and P. R. Dobner, Cloning of human neurotensin/neuromedin N genomic sequences and expression in the ventral mesencephalon of schizophrenics and age/sex matched controls, Neuroscience, vol.50, pp.259-268, 1992.

S. A. Beers, R. R. French, H. T. Chan, S. H. Lim, T. C. Jarrett et al., Antigenic modulation limits the efficacy of anti-CD20 antibodies: implications for antibody selection, Blood, vol.115, pp.5191-5201, 2010.

C. Bellanger, L. Dubanet, M. Lise, A. Fauchais, D. Bordessoule et al., Endogenous neurotrophins and Trk signaling in diffuse large B cell lymphoma cell lines are involved in sensitivity to rituximab-induced apoptosis, PloS One, vol.6, 2011.
URL : https://hal.archives-ouvertes.fr/hal-00873135

S. Béraud-dufour, T. Coppola, F. Massa, and J. Mazella, Neurotensin receptor-2 and-3 are crucial for the anti-apoptotic effect of neurotensin on pancreatic beta-TC3 cells, Int. J. Biochem. Cell Biol, vol.41, pp.2398-2402, 2009.

E. Bergman, B. Ulfhake, and B. T. Fundin, Regulation of NGF-family ligands and receptors in adulthood and senescence: correlation to degenerative and regenerative changes in cutaneous innervation, Eur. J. Neurosci, vol.12, pp.2694-2706, 2000.

L. R. Berkemeier, J. W. Winslow, D. R. Kaplan, K. Nikolics, D. V. Goeddel et al., Neurotrophin-5: a novel neurotrophic factor that activates trk and trkB, Neuron, vol.7, pp.857-866, 1991.

A. Bernal, R. D. Pastore, Z. Asgary, S. A. Keller, E. Cesarman et al., Survival of leukemic B cells promoted by engagement of the antigen receptor, Blood, vol.98, pp.3050-3057, 2001.

S. I. Berndt, C. F. Skibola, V. Joseph, N. J. Camp, A. Nieters et al., Genome-wide association study identifies multiple risk loci for chronic lymphocytic leukemia, Nat. Genet, vol.45, pp.868-876, 2013.

M. Besser and R. Wank, Cutting edge: clonally restricted production of the neurotrophins brain-derived neurotrophic factor and neurotrophin-3 mRNA by human immune cells and Th1/Th2-polarized expression of their receptors, J. Immunol. Baltim. Md, vol.162, pp.6303-6306, 1950.

C. Betancur, M. Canton, A. Burgos, B. Labeeuw, D. Gully et al., Characterization of binding sites of a new neurotensin receptor antagonist, the rat brain, vol.343, pp.67-77, 1998.
URL : https://hal.archives-ouvertes.fr/inserm-00276332

G. Beutel, J. Meyer, L. Ma, S. Yin, M. Eder et al., Expression of the p75 neurotrophin receptor in acute leukaemia, Br. J. Haematol, vol.131, pp.67-70, 2005.

S. Biffo, N. Offenhäuser, B. D. Carter, B. , and Y. A. , Selective binding and internalisation by truncated receptors restrict the availability of BDNF during development, Dev. Camb. Engl, vol.121, pp.2461-2470, 1995.

T. R. Bilderback, V. R. Gazula, M. P. Lisanti, and R. T. Dobrowsky, Caveolin interacts with Trk A and p75(NTR) and regulates neurotrophin signaling pathways, J. Biol. Chem, vol.274, pp.257-263, 1999.
DOI : 10.1074/jbc.274.1.257

URL : http://www.jbc.org/content/274/1/257.full.pdf

J. L. Binet, A. Auquier, G. Dighiero, C. Chastang, H. Piguet et al., A new prognostic classification of chronic lymphocytic leukemia derived from a multivariate survival analysis, Cancer, vol.48, pp.198-206, 1981.

J. S. Biscardi, M. C. Maa, D. A. Tice, M. E. Cox, T. H. Leu et al., c-Srcmediated phosphorylation of the epidermal growth factor receptor on Tyr845 and Tyr1101 is associated with modulation of receptor function, J. Biol. Chem, vol.274, pp.8335-8343, 1999.

D. R. Boggs, S. C. Chen, Z. N. Zhang, and A. Zhang, Chronic lymphocytic leukemia in China, Am. J. Hematol, vol.25, pp.349-354, 1987.

J. M. Botto, J. Chabry, D. Nouel, M. Paquet, P. Séguéla et al., Identification in the rat neurotensin receptor of amino-acid residues critical for the binding of neurotensin, Brain Res. Mol. Brain Res, vol.46, pp.311-317, 1997.

J. M. Botto, E. Guillemare, J. P. Vincent, and J. Mazella, Effects of SR 48692 on neurotensin-induced calcium-activated chloride currents in the Xenopus oocyte expression system: agonist-like activity on the levocabastine-sensitive neurotensin receptor and absence of antagonist effect on the levocabastine insensitive neurotensin receptor, Neurosci. Lett, vol.223, pp.193-196, 1997.

J. M. Botto, J. Chabry, P. Sarret, J. P. Vincent, and J. Mazella, Stable expression of the mouse levocabastine-sensitive neurotensin receptor in HEK 293 cell line: binding properties, photoaffinity labeling, and internalization mechanism, Biochem. Biophys. Res. Commun, vol.243, pp.585-590, 1998.

H. Boudin, D. Pélaprat, W. Rostène, and A. Beaudet, Cellular distribution of neurotensin receptors in rat brain: immunohistochemical study using an antipeptide antibody against the cloned high affinity receptor, J. Comp. Neurol, vol.373, pp.76-89, 1996.

H. Boudin, B. Lazaroff, C. M. Bachelet, D. Pélaprat, W. Rostène et al., , 2000.

, Immunologic differentiation of two high-affinity neurotensin receptor isoforms in the developing rat brain, J. Comp. Neurol, vol.425, pp.45-57

M. Boules, Z. Li, K. Smith, P. Fredrickson, R. et al., Diverse roles of neurotensin agonists in the central nervous system, 2013.

J. Bouley, L. Deriano, J. Delic, M. , and H. , New molecular markers in resistant B-CLL, Leuk. Lymphoma, vol.47, pp.791-801, 2006.
DOI : 10.1080/10428190500513835

J. C. Bozou, S. Amar, J. P. Vincent, and P. Kitabgi, Neurotensin-mediated inhibition of cyclic AMP formation in neuroblastoma N1E115 cells: involvement of the inhibitory GTPbinding component of adenylate cyclase, Mol. Pharmacol, vol.29, pp.489-496, 1986.

M. Bozzola, A. N. Thome, E. Giraldi, A. M. Lhiaubet, and R. M. Schimpff, Plasma neurotensin levels in prepubertal children and adults: possible involvement in the regulation of growth hormone secretion, J. Pediatr. Endocrinol. Metab. JPEM, vol.11, pp.615-621, 1998.

R. A. Bradshaw, J. Pundavela, J. Biarc, R. J. Chalkley, A. L. Burlingame et al., NGF and ProNGF: Regulation of neuronal and neoplastic responses through receptor signaling, Adv. Biol. Regul, vol.58, pp.16-27, 2015.
DOI : 10.1016/j.jbior.2014.11.003

URL : http://europepmc.org/articles/pmc4426037?pdf=render

K. Breitschopf, J. Haendeler, P. Malchow, A. M. Zeiher, and S. Dimmeler, Posttranslational modification of Bcl-2 facilitates its proteasome-dependent degradation: molecular characterization of the involved signaling pathway, Mol. Cell. Biol, vol.20, pp.1886-1896, 2000.

L. Breuza, M. Garcia, M. Delgrossi, L. Bivic, and A. , Role of the membraneproximal O-glycosylation site in sorting of the human receptor for neurotrophins to the apical membrane of MDCK cells, Exp. Cell Res, vol.273, pp.178-186, 2002.
URL : https://hal.archives-ouvertes.fr/hal-00306518

G. M. Brodeur, J. E. Minturn, R. Ho, A. M. Simpson, R. Iyer et al., Trk receptor expression and inhibition in neuroblastomas, Clin. Cancer Res. Off. J. Am. Assoc. Cancer Res, vol.15, pp.3244-3250, 2009.
DOI : 10.1158/1078-0432.ccr-08-1815

URL : http://clincancerres.aacrjournals.org/content/15/10/3244.full.pdf

F. C. Bronfman, Metalloproteases and gamma-secretase: new membrane partners regulating p75 neurotrophin receptor signaling?, J. Neurochem, vol.103, issue.1, pp.91-100, 2007.
DOI : 10.1111/j.1471-4159.2007.04781.x

URL : https://onlinelibrary.wiley.com/doi/pdf/10.1111/j.1471-4159.2007.04781.x

F. C. Bronfman and M. Fainzilber, Multi-tasking by the p75 neurotrophin receptor: sortilin things out?, EMBO Rep, vol.5, pp.867-871, 2004.

J. R. Brown, J. C. Byrd, S. E. Coutre, D. M. Benson, I. W. Flinn et al., Idelalisib, an inhibitor of phosphatidylinositol 3-kinase p110?, for relapsed/refractory chronic lymphocytic leukemia, Blood, vol.123, pp.3390-3397, 2014.

J. R. Brown, B. Tesar, L. Yu, L. Werner, N. Takebe et al., Obatoclax in combination with fludarabine and rituximab is well-tolerated and shows promising clinical activity in relapsed chronic lymphocytic leukemia, Leuk. Lymphoma, vol.56, pp.3336-3342, 2015.

P. Brun, C. Mastrotto, E. Beggiao, A. Stefani, L. Barzon et al., Neuropeptide neurotensin stimulates intestinal wound healing following chronic intestinal inflammation, Am. J. Physiol. Gastrointest. Liver Physiol, vol.288, pp.621-629, 2005.

D. Brusa, S. Serra, M. Coscia, D. Rossi, G. D'arena et al., The PD-1/PD-L1 axis contributes to T-cell dysfunction in chronic lymphocytic leukemia, Haematologica, vol.98, pp.953-963, 2013.

J. Budni, T. Bellettini-santos, F. Mina, M. L. Garcez, and A. I. Zugno, The involvement of BDNF, NGF and GDNF in aging and Alzheimer's disease, Aging Dis, vol.6, pp.331-341, 2015.

J. M. Bugni, P. , and C. , Neurotensin. Handb. Biol. Act. Pept, pp.1265-1270, 2013.

J. M. Bugni, L. Al-rabadi, K. Jubbal, I. Karagiannides, G. Lawson et al., The neurotensin receptor-1 promotes tumor development in a sporadic but not an inflammation-associated mouse model of colon cancer, Int. J. Cancer J. Int. Cancer, vol.130, pp.1798-1805, 2012.

G. Bunone, A. Mariotti, A. Compagni, E. Morandi, D. Valle et al., Induction of apoptosis by p75 neurotrophin receptor in human neuroblastoma cells, Oncogene, vol.14, pp.1463-1470, 1997.

J. A. Burger, M. Burger, and T. J. Kipps, Chronic lymphocytic leukemia B cells express functional CXCR4 chemokine receptors that mediate spontaneous migration beneath bone marrow stromal cells, Blood, vol.94, pp.3658-3667, 1999.

B. Bürgi, U. H. Otten, B. Ochensberger, S. Rihs, K. Heese et al., Basophil priming by neurotrophic factors. Activation through the trk receptor, J. Immunol. Baltim. Md, vol.157, pp.5582-5588, 1950.

J. C. Byrd, K. A. Blum, J. A. Burger, S. E. Coutre, J. P. Sharman et al., Activity and tolerability of the Bruton's tyrosine kinase (Btk) inhibitor PCI-32765 in patients with chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL): Interim results of a phase Ib/II study, J. Clin. Oncol, vol.29, pp.6508-6508, 2011.

J. C. Byrd, B. Harrington, S. O'brien, J. A. Jones, A. Schuh et al., Acalabrutinib (ACP-196) in Relapsed Chronic Lymphocytic Leukemia, N. Engl. J. Med, vol.374, pp.323-332, 2016.

F. Caligaris-cappio, Role of the microenvironment in chronic lymphocytic leukaemia, Br. J. Haematol, vol.123, pp.380-388, 2003.

F. Caligaris-cappio and T. J. Hamblin, B-Cell Chronic Lymphocytic Leukemia: A Bird of a Different Feather, J. Clin. Oncol, vol.17, pp.399-399, 1999.

G. A. Calin, M. Ferracin, A. Cimmino, G. Di-leva, M. Shimizu et al., A MicroRNA signature associated with prognosis and progression in chronic lymphocytic leukemia, N. Engl. J. Med, vol.353, pp.1793-1801, 2005.

C. Calissano, R. N. Damle, G. Hayes, E. J. Murphy, M. K. Hellerstein et al., In vivo intraclonal and interclonal kinetic heterogeneity in B-cell chronic lymphocytic leukemia, Blood, vol.114, pp.4832-4842, 2009.

S. Capalbo, P. Trerotoli, A. Ciancio, C. Battista, G. Serio et al., Increased risk of lymphoproliferative disorders in relatives of patients with B-cell chronic lymphocytic leukemia: relevance of the degree of familial linkage, Eur. J. Haematol, vol.65, pp.114-117, 2000.

M. C. Caroleo, N. Costa, L. Bracci-laudiero, A. , and L. , Human monocyte/macrophages activate by exposure to LPS overexpress NGF and NGF receptors, J. Neuroimmunol, vol.113, pp.193-201, 2001.

R. Carraway and Y. M. Bhatnagar, Immunochemical characterization of neurotensinlike peptides in chicken, Peptides, vol.1, pp.159-165, 1980.

R. E. Carraway, M. , and S. P. , The use of radioimmunoassay to compare the tissue and subcellular distributions of neurotensin and neuromedin N in the cat, Endocrinology, vol.120, pp.2092-2100, 1987.

R. Carraway and S. E. Leeman, The isolation of a new hypotensive peptide, neurotensin, from bovine hypothalami, J. Biol. Chem, vol.248, pp.6854-6861, 1973.

R. Carraway and S. E. Leeman, The amino acid sequence of a hypothalamic peptide, neurotensin, J. Biol. Chem, vol.250, pp.1907-1911, 1975.

R. Carraway and S. E. Leeman, Characterization of radioimmunoassayable neurotensin in the rat. Its differential distribution in the central nervous system, small intestine, and stomach, J. Biol. Chem, vol.251, pp.7045-7052, 1976.

R. E. Carraway, S. P. Mitra, and C. Paradise, Characterization of large neuromedinN using antisera towards regions of the neurotensin/neuromedin-N precursor, Peptides, vol.12, pp.601-607, 1991.

R. E. Carraway, S. P. Mitra, J. , and T. J. , Tissue-specific processing of neurotensin/neuromedin-N precursor in cat, Regul. Pept, vol.43, pp.97-106, 1993.

B. D. Carter, C. Kaltschmidt, B. Kaltschmidt, N. Offenhäuser, R. Böhm-matthaei et al., Selective activation of NF-kappa B by nerve growth factor through the neurotrophin receptor p75, Science, vol.272, pp.542-545, 1996.

P. Casaccia-bonnefil, C. Gu, and M. V. Chao, Neurotrophins in cell survival/death decisions, Adv. Exp. Med. Biol, vol.468, pp.275-282, 1999.

P. Casaccia-bonnefil, C. Gu, G. Khursigara, and M. V. Chao, p75 neurotrophin receptor as a modulator of survival and death decisions, Microsc. Res. Tech, vol.45, pp.217-224, 1999.

E. Casademunt, B. D. Carter, I. Benzel, J. M. Frade, G. Dechant et al., The zinc finger protein NRIF interacts with the neurotrophin receptor p75(NTR) and participates in programmed cell death, EMBO J, vol.18, pp.6050-6061, 1999.

R. D. Cassaday, B. E. Storer, M. L. Sorror, B. M. Sandmaier, K. A. Guthrie et al., Long-term outcomes of patients with persistent indolent B cell malignancies undergoing nonmyeloablative allogeneic transplantation, Biol. Blood Marrow Transplant. J. Am. Soc. Blood Marrow Transplant, vol.21, pp.281-287, 2015.

D. Cassiman, C. Denef, V. J. Desmet, R. , and T. , Human and rat hepatic stellate cells express neurotrophins and neurotrophin receptors, Hepatol. Baltim. Md, vol.33, pp.148-158, 2001.

I. Castagliuolo, C. C. Wang, L. Valenick, A. Pasha, S. Nikulasson et al., Neurotensin is a proinflammatory neuropeptide in colonic inflammation, J. Clin. Invest, vol.103, pp.843-849, 1999.

F. Cattaneo, G. Guerra, M. Parisi, M. De-marinis, D. Tafuri et al., Cell-surface receptors transactivation mediated by g protein-coupled receptors, Int. J. Mol. Sci, vol.15, pp.19700-19728, 2014.

J. Chabry, C. Labbé-jullié, D. Gully, P. Kitabgi, J. P. Vincent et al., Stable expression of the cloned rat brain neurotensin receptor into fibroblasts: binding properties, photoaffinity labeling, transduction mechanisms, and internalization, J. Neurochem, vol.63, pp.19-27, 1994.

J. Chabry, J. M. Botto, D. Nouel, A. Beaudet, J. P. Vincent et al., Thr-422 and Tyr-424 residues in the carboxyl terminus are critical for the internalization of the rat neurotensin receptor, J. Biol. Chem, vol.270, pp.2439-2442, 1995.

P. Chalon, N. Vita, M. Kaghad, M. Guillemot, J. Bonnin et al., Molecular cloning of a levocabastine-sensitive neurotensin binding site, FEBS Lett, vol.386, pp.91-94, 1996.

A. Chanan-khan, K. C. Miller, L. Musial, D. Lawrence, S. Padmanabhan et al., Clinical efficacy of lenalidomide in patients with relapsed or refractory chronic lymphocytic leukemia: results of a phase II study, J. Clin. Oncol. Off. J. Am. Soc. Clin. Oncol, vol.24, pp.5343-5349, 2006.

M. Chang, J. C. Arevalo, and M. V. Chao, Ternary complex with Trk, p75, and an ankyrin-rich membrane spanning protein, J. Neurosci. Res, vol.78, pp.186-192, 2004.

M. V. Chao, Neurotrophins and their receptors: a convergence point for many signalling pathways, Nat. Rev. Neurosci, vol.4, pp.299-309, 2003.

M. V. Chao, Neurotrophins and their receptors: a convergence point for many signalling pathways, Nat. Rev. Neurosci, vol.4, pp.299-309, 2003.
DOI : 10.1038/nrn1078

D. T. Chao and S. J. Korsmeyer, BCL-2 family: regulators of cell death, Annu. Rev. Immunol, vol.16, pp.395-419, 1998.
DOI : 10.1146/annurev.immunol.16.1.395

M. V. Chao, M. A. Bothwell, A. H. Ross, H. Koprowski, A. A. Lanahan et al., Gene transfer and molecular cloning of the human NGF receptor, Science, vol.232, pp.518-521, 1986.
DOI : 10.1126/science.3008331

E. Chapiro, I. Radford-weiss, C. Bastard, I. Luquet, C. Lefebvre et al., The most frequent t(14;19)(q32;q13)-positive B-cell malignancy corresponds to an aggressive subgroup of atypical chronic lymphocytic leukemia, Leukemia, vol.22, pp.2123-2127, 2008.

E. Chapiro, N. Leporrier, I. Radford-weiss, C. Bastard, H. Mossafa et al., Gain of the short arm of chromosome 2 (2p) is a frequent recurring chromosome aberration in untreated chronic lymphocytic leukemia (CLL) at advanced stages, Leuk. Res, vol.34, pp.63-68, 2010.

F. Checler, J. P. Vincent, and P. Kitabgi, Purification and characterization of a novel neurotensin-degrading peptidase from rat brain synaptic membranes, J. Biol. Chem, vol.261, pp.11274-11281, 1986.

F. Checler, H. Barelli, P. Kitabgi, and J. P. Vincent, Neurotensin metabolism in various tissues of central and peripheral origins: ubiquitous involvement of a novel neurotensin degrading metalloendopeptidase, Biochimie, vol.70, pp.75-82, 1988.

L. Chen, G. Widhopf, L. Huynh, L. Rassenti, K. R. Rai et al., Expression of ZAP-70 is associated with increased B-cell receptor signaling in chronic lymphocytic leukemia, Blood, vol.100, pp.4609-4614, 2002.

Z. Chen, A. Ieraci, H. Teng, H. Dall, C. Meng et al., Sortilin controls intracellular sorting of brain-derived neurotrophic factor to the regulated secretory pathway, J. Neurosci. Off. J. Soc. Neurosci, vol.25, pp.6156-6166, 2005.

B. D. Cheson, Monoclonal antibody therapy of chronic lymphocytic leukaemia, Best Pract. Res. Clin. Haematol, vol.23, pp.133-143, 2010.
DOI : 10.1016/j.beha.2010.01.006

N. Chiorazzi and M. Ferrarini, Cellular origin(s) of chronic lymphocytic leukemia: cautionary notes and additional considerations and possibilities, Blood, vol.117, pp.1781-1791, 2011.

Y. Demont, C. Corbet, A. Page, Y. Ataman-Önal, G. Choquet-kastylevsky et al., Pro-nerve growth factor induces autocrine stimulation of breast cancer cell invasion through tropomyosinrelated kinase A (TrkA) and sortilin protein, J. Biol. Chem, vol.287, pp.1923-1931, 2012.

E. Dicou, J. Vincent, and J. Mazella, Neurotensin receptor-3/sortilin mediates neurotensin-induced cytokine/chemokine expression in a murine microglial cell line, J. Neurosci. Res, vol.78, pp.92-99, 2004.
DOI : 10.1002/jnr.20231

G. Dighiero and T. J. Hamblin, Chronic lymphocytic leukaemia, The Lancet, vol.371, pp.1017-1029, 2008.
URL : https://hal.archives-ouvertes.fr/pasteur-00838819

G. Dighiero, K. Maloum, B. Desablens, B. Cazin, M. Navarro et al., Chlorambucil in indolent chronic lymphocytic leukemia. French Cooperative Group on Chronic Lymphocytic Leukemia, N. Engl. J. Med, vol.338, pp.1506-1514, 1998.
DOI : 10.1056/nejm199805213382104

P. S. Distefano, D. M. Chelsea, C. M. Schick, and J. F. Mckelvy, Involvement of a metalloprotease in low-affinity nerve growth factor receptor truncation: inhibition of truncation in vitro and in vivo, J. Neurosci. Off. J. Soc. Neurosci, vol.13, pp.2405-2414, 1993.

P. R. Dobner, Multitasking with neurotensin in the central nervous system, Cell. Mol. Life Sci. CMLS, vol.62, pp.1946-1963, 2005.

P. R. Dobner, Neurotensin and pain modulation, Peptides, vol.27, pp.2405-2414, 2006.
DOI : 10.1016/j.peptides.2006.04.025

P. R. Dobner, D. L. Barber, L. Villa-komaroff, and C. Mckiernan, Cloning and sequence analysis of cDNA for the canine neurotensin/neuromedin N precursor, Proc. Natl. Acad. Sci. U. S. A, vol.84, pp.3516-3520, 1987.

H. Döhner, S. Stilgenbauer, M. R. James, A. Benner, T. Weilguni et al., 11q deletions identify a new subset of B-cell chronic lymphocytic leukemia characterized by extensive nodal involvement and inferior prognosis, Blood, vol.89, pp.2516-2522, 1997.

H. Döhner, S. Stilgenbauer, A. Benner, E. Leupolt, A. Kröber et al., Genomic aberrations and survival in chronic lymphocytic leukemia, N. Engl. J. Med, vol.343, pp.1910-1916, 2000.

M. Domeniconi and M. V. Chao, Transactivation of Trk receptors in spinal motor neurons, Histol. Histopathol, vol.25, pp.1207-1213, 2010.

Z. Dong, X. Wang, Q. Zhao, C. M. Townsend, and B. M. Evers, DNA methylation contributes to expression of the human neurotensin/neuromedin N gene, Am. J. Physiol, vol.274, pp.535-543, 1998.

Z. Dong, X. Wang, and B. M. Evers, Site-specific DNA methylation contributes to neurotensin/neuromedin N expression in colon cancers, Am. J. Physiol. Gastrointest. Liver Physiol, vol.279, pp.1139-1147, 2000.
DOI : 10.1152/ajpgi.2000.279.6.g1139

Z. Dong, Q. Lei, R. Yang, S. Zhu, X. Ke et al., Inhibition of neurotensin receptor 1 induces intrinsic apoptosis via let-7a-3p/Bcl-w axis in glioblastoma, Br. J. Cancer, vol.116, pp.1572-1584, 2017.

D. Onofrio, M. De-grazia, U. Morrone, S. Cuomo, L. Spinsanti et al., Expression of neurotrophin receptors in normal and malignant B lymphocytes, Eur. Cytokine Netw, vol.11, pp.283-291, 2000.

R. T. Dorsam and J. S. Gutkind, G-protein-coupled receptors and cancer, Nat. Rev. Cancer, vol.7, pp.79-94, 2007.

P. Dreger, P. Corradini, E. Kimby, M. Michallet, D. Milligan et al., Indications for allogeneic stem cell transplantation in chronic lymphocytic leukemia: the EBMT transplant consensus, Leukemia, vol.21, pp.12-17, 2007.
DOI : 10.1038/sj.leu.2404441

URL : https://www.nature.com/articles/2404441.pdf

P. Dreger, A. Schnaiter, T. Zenz, S. Böttcher, M. Rossi et al., TP53, SF3B1, and NOTCH1 mutations and outcome of allotransplantation for chronic lymphocytic leukemia: six-year follow-up of the GCLLSG CLL3X trial, Blood, vol.121, pp.3284-3288, 2013.

A. C. Drost, G. Seitz, A. Boehmler, M. Funk, K. P. Norz et al., The G protein-coupled receptor CysLT1 mediates chemokine-like effects and prolongs survival in chronic lymphocytic leukemia, Leuk. Lymphoma, vol.53, pp.665-673, 2012.
DOI : 10.3109/10428194.2011.625578

L. Dubanet, H. Bentayeb, B. Petit, A. Olivrie, S. Saada et al., Anti-apoptotic role and clinical relevance of neurotrophins in diffuse large B-cell lymphomas, Br. J. Cancer, vol.113, pp.934-944, 2015.
URL : https://hal.archives-ouvertes.fr/hal-01819218

I. Dubuc, J. Costentin, J. P. Terranova, M. C. Barnouin, P. Soubrié et al., The nonpeptide neurotensin antagonist, SR 48692, used as a tool to reveal putative neurotensin receptor subtypes, Br. J. Pharmacol, vol.112, pp.352-354, 1994.
DOI : 10.1111/j.1476-5381.1994.tb13077.x

URL : http://europepmc.org/articles/pmc1910364?pdf=render

I. Dubuc, P. Sarret, C. Labbé-jullié, J. M. Botto, E. Honoré et al., Identification of the receptor subtype involved in the analgesic effect of neurotensin, J. Neurosci. Off. J. Soc. Neurosci, vol.19, pp.503-510, 1999.

S. Dupouy, N. Mourra, V. K. Doan, A. Gompel, M. Alifano et al., The potential use of the neurotensin high affinity receptor 1 as a biomarker for cancer progression and as a component of personalized medicine in selective cancers, Biochimie, vol.93, pp.1369-1378, 2011.

S. Dupouy, V. K. Doan, Z. Wu, N. Mourra, J. Liu et al., Activation of EGFR, HER2 and HER3 by neurotensin/neurotensin receptor 1 renders breast tumors aggressive yet highly responsive to lapatinib and metformin in mice, Oncotarget, vol.5, pp.8235-8251, 2014.

J. Dürig, U. Dührsen, L. Klein-hitpass, J. Worm, J. B. Hansen et al., The novel antisense Bcl-2 inhibitor SPC2996 causes rapid leukemic cell clearance and immune activation in chronic lymphocytic leukemia, Leukemia, vol.25, pp.638-647, 2011.

M. J. Dyer, V. J. Zani, W. Z. Lu, A. O'byrne, S. Mould et al., BCL2 translocations in leukemias of mature B cells, Blood, vol.83, pp.3682-3688, 1994.

J. Edelmann, K. Holzmann, F. Miller, D. Winkler, A. Bühler et al., High-resolution genomic profiling of chronic lymphocytic leukemia reveals new recurrent genomic alterations, Blood, vol.120, pp.4783-4794, 2012.
DOI : 10.1182/blood-2012-04-423517

URL : http://www.bloodjournal.org/content/120/24/4783.full.pdf

A. Eggert, H. Sieverts, N. Ikegaki, and G. M. Brodeur, p75 mediated apoptosis in neuroblastoma cells is inhibited by expression of TrkA, Med. Pediatr. Oncol, vol.35, pp.573-576, 2000.

R. A. Ehlers, R. M. Bonnor, X. Wang, M. R. Hellmich, and B. M. Evers, Signal transduction mechanisms in neurotensin-mediated cellular regulation, Surgery, vol.124, pp.246-247, 1998.
DOI : 10.1067/msy.1998.90370

P. B. Ehrhard, P. Erb, U. Graumann, and U. Otten, Expression of nerve growth factor and nerve growth factor receptor tyrosine kinase Trk in activated CD4-positive T-cell clones, Proc. Natl. Acad. Sci. U. S. A, vol.90, pp.10984-10988, 1993.
DOI : 10.1073/pnas.90.23.10984

URL : http://www.pnas.org/content/90/23/10984.full.pdf

B. Eichhorst, A. Fink, J. Bahlo, R. Busch, G. Kovacs et al., First-line chemoimmunotherapy with bendamustine and rituximab versus fludarabine, cyclophosphamide, and rituximab in patients with advanced chronic lymphocytic leukaemia (CLL10): an international, open-label, randomised, phase 3, non-inferiority trial, Lancet Oncol, vol.17, pp.928-942, 2016.
DOI : 10.1016/s1470-2045(16)30051-1

J. Einsiedel, C. Held, M. Hervet, M. Plomer, N. Tschammer et al., Discovery of highly potent and neurotensin receptor 2 selective neurotensin mimetics, J. Med. Chem, vol.54, pp.2915-2923, 2011.
DOI : 10.1021/jm200006c

R. Elde, M. Schalling, S. Ceccatelli, S. Nakanishi, and T. Hökfelt, Localization of neuropeptide receptor mRNA in rat brain: initial observations using probes for neurotensin and substance P receptors, Neurosci. Lett, vol.120, pp.134-138, 1990.

H. M. El-shewy, K. R. Johnson, M. Lee, A. A. Jaffa, L. M. Obeid et al., Insulin-like growth factors mediate heterotrimeric G protein-dependent ERK1/2 activation by transactivating sphingosine 1-phosphate receptors, J. Biol. Chem, vol.281, pp.31399-31407, 2006.
DOI : 10.1074/jbc.m605339200

URL : http://www.jbc.org/content/281/42/31399.full.pdf

P. C. Emson, P. M. Horsfield, M. Goedert, M. N. Rossor, and C. H. Hawkes, , 1985.

, Neurotensin in human brain: regional distribution and effects of neurological illness, Brain Res, vol.347, pp.239-244

M. Encinas, M. Iglesias, N. Llecha, and J. X. Comella, Extracellular-regulated kinases and phosphatidylinositol 3-kinase are involved in brain-derived neurotrophic factormediated survival and neuritogenesis of the neuroblastoma cell line SH-SY5Y, J. Neurochem, vol.73, pp.1409-1421, 1999.

B. M. Evers, R. J. Bold, J. A. Ehrenfried, J. Li, C. M. Townsend et al., Characterization of functional neurotensin receptors on human lymphocytes, Surgery, vol.116, pp.139-140, 1994.

S. Evrard, P. Gaussem, D. Helley, D. , and L. , , 2005.

, Ann. Biol. Clin. (Paris), vol.63, pp.589-597

A. Fauchais, F. Lalloué, M. Lise, A. Boumediene, J. Preud'homme et al., Role of endogenous brain-derived neurotrophic factor and sortilin in B cell survival, J. Immunol. Baltim. Md, vol.181, pp.3027-3038, 1950.
URL : https://hal.archives-ouvertes.fr/hal-00453223

P. Fenaux, C. Preudhomme, J. L. Laï, I. Quiquandon, P. Jonveaux et al., Mutations of the p53 gene in B-cell chronic lymphocytic leukemia: a report on 39 cases with cytogenetic analysis, Leukemia, vol.6, pp.246-250, 1992.

A. Ferrajoli, B. Lee, E. J. Schlette, S. M. O'brien, H. Gao et al., Lenalidomide induces complete and partial remissions in patients with relapsed and refractory chronic lymphocytic leukemia, Blood, vol.111, pp.5291-5297, 2008.
DOI : 10.1182/blood-2007-12-130120

URL : http://www.bloodjournal.org/content/111/11/5291.full.pdf

A. A. Filip, B. Cise?, D. Koczkodaj, E. W?sik-szczepanek, T. Piersiak et al., Circulating microenvironment of CLL: are nurse-like cells related to tumor-associated macrophages?, Blood Cells. Mol. Dis, vol.50, pp.263-270, 2013.
DOI : 10.1016/j.bcmd.2012.12.003

S. Fiorcari, W. S. Brown, B. W. Mcintyre, Z. Estrov, R. Maffei et al., The PI3-kinase delta inhibitor idelalisib (GS-1101) targets integrin-mediated adhesion of chronic lymphocytic leukemia (CLL) cell to endothelial and marrow stromal cells, PloS One, vol.8, p.83830, 2013.

E. D. Foehr, X. Lin, A. O'mahony, R. Geleziunas, R. A. Bradshaw et al., NF-kappa B signaling promotes both cell survival and neurite process formation in nerve growth factor-stimulated PC12 cells, J. Neurosci. Off. J. Soc. Neurosci, vol.20, pp.7556-7563, 2000.

K. A. Foon and R. P. Gale, Clinical transformation of chronic lymphocytic leukemia, Nouv. Rev. Fr. Hematol, vol.30, pp.385-388, 1988.

K. A. Foon, D. Mehta, S. Lentzsch, P. Kropf, S. Marks et al., Long-term results of chemoimmunotherapy with low-dose fludarabine, cyclophosphamide and high-dose rituximab as initial treatment for patients with chronic lymphocytic leukemia, Blood, vol.119, pp.3184-3185, 2012.

J. W. Friedberg, J. Sharman, J. Sweetenham, P. B. Johnston, J. M. Vose et al., Inhibition of Syk with fostamatinib disodium has significant clinical activity in non-Hodgkin lymphoma and chronic lymphocytic leukemia, Blood, vol.115, pp.2578-2585, 2010.

R. H. Fryer, D. R. Kaplan, and L. F. Kromer, Truncated trkB receptors on nonneuronal cells inhibit BDNF-induced neurite outgrowth in vitro, Exp. Neurol, vol.148, pp.616-627, 1997.

M. De-la-fuente, J. J. Garrido, R. M. Arahuetes, and A. Hernanz, Stimulation of phagocytic function in mouse macrophages by neurotensin and neuromedin N, J. Neuroimmunol, vol.42, pp.97-104, 1993.

T. Fukuda, L. Chen, T. Endo, L. Tang, D. Lu et al., Antisera induced by infusions of autologous AdCD154-leukemia B cells identify ROR1 as an oncofetal antigen and receptor for Wnt5a, Proc. Natl. Acad. Sci. U. S. A, vol.105, pp.3047-3052, 2008.

G. Gahrton, K. H. Robert, K. Friberg, G. Juliusson, P. Biberfeld et al., , 1982.

, Cytogenetic mapping of the duplicated segment of chromosome 12 in lymphoproliferative disorders, Nature, vol.297, pp.513-514

G. Gaidano, R. Foà, and R. Dalla-favera, Molecular pathogenesis of chronic lymphocytic leukemia, J. Clin. Invest, vol.122, pp.3432-3438, 2012.

P. Gailly, M. Najimi, and E. Hermans, Evidence for the dual coupling of the rat neurotensin receptor with pertussis toxin-sensitive and insensitive G-proteins, FEBS Lett, vol.483, pp.109-113, 2000.

O. García-suárez, A. Germanà, J. Hannestad, E. Ciriaco, R. Laurà et al., TrkA is necessary for the normal development of the murine thymus, J. Neuroimmunol, vol.108, pp.11-21, 2000.

O. Garcia-suarez, M. A. Blanco-gelaz, M. L. Lopez, A. Germana, R. Cabo et al., Massive lymphocyte apoptosis in the thymus of functionally deficient TrkB mice, J. Neuroimmunol, vol.129, pp.25-34, 2002.

J. J. Garrido, R. M. Arahuetes, A. Hernanz, and M. De-la-fuente, Modulation by neurotensin and neuromedin N of adherence and chemotaxis capacity of murine lymphocytes, Regul. Pept, vol.41, pp.27-37, 1992.

T. Geetha, R. S. Kenchappa, M. W. Wooten, and B. D. Carter, TRAF6-mediated ubiquitination regulates nuclear translocation of NRIF, the p75 receptor interactor, EMBO J, vol.24, pp.3859-3868, 2005.

L. Gendron, A. Perron, M. D. Payet, N. Gallo-payet, P. Sarret et al., , 2004.

, Low-affinity neurotensin receptor (NTS2) signaling: internalization-dependent activation of extracellular signal-regulated kinases 1/2, Mol. Pharmacol, vol.66, pp.1421-1430

M. Gentile, G. Cutrona, A. Neri, S. Molica, M. Ferrarini et al., , 2009.

, Predictive value of beta2-microglobulin (beta2-m) levels in chronic lymphocytic leukemia since Binet A stages, Haematologica, vol.94, pp.887-888

H. Ghamlouch, F. Nguyen-khac, and O. A. Bernard, Chronic lymphocytic leukaemia genomics and the precision medicine era, Br. J. Haematol, 2017.
URL : https://hal.archives-ouvertes.fr/hal-01568354

E. M. Ghia, S. Jain, G. F. Widhopf, L. Z. Rassenti, M. J. Keating et al., Use of IGHV3-21 in chronic lymphocytic leukemia is associated with high-risk disease and reflects antigen-driven, post-germinal center leukemogenic selection, Blood, vol.111, pp.5101-5108, 2008.

P. Ghia, G. Guida, S. Stella, D. Gottardi, M. Geuna et al., The pattern of CD38 expression defines a distinct subset of chronic lymphocytic leukemia (CLL) patients at risk of disease progression, Blood, vol.101, pp.1262-1269, 2003.

P. Ghia, A. M. Ferreri, C. , and F. , Chronic lymphocytic leukemia, Crit. Rev. Oncol. Hematol, vol.64, pp.234-246, 2007.
URL : https://hal.archives-ouvertes.fr/hal-01375537

A. K. Ghosh, K. , and N. E. , Critical signal transduction pathways in CLL, Adv. Exp. Med. Biol, vol.792, pp.215-239, 2013.

J. Gibon and P. A. Barker, Neurotrophins and Proneurotrophins, Neurosci. Rev. J. Bringing Neurobiol. Neurol. Psychiatry, 2017.

A. M. Gilmour, S. Abdulkhalek, T. S. Cheng, F. Alghamdi, P. Jayanth et al., A novel epidermal growth factor receptor-signaling platform and its targeted translation in pancreatic cancer, Cell. Signal, vol.25, pp.2587-2603, 2013.
DOI : 10.1016/j.cellsig.2013.08.008

URL : https://doi.org/10.1016/j.cellsig.2013.08.008

S. Gobessi, L. Laurenti, P. G. Longo, L. Carsetti, V. Berno et al., Inhibition of constitutive and BCR-induced Syk activation downregulates Mcl-1 and induces apoptosis in chronic lymphocytic leukemia B cells, Leukemia, vol.23, pp.686-697, 2009.
DOI : 10.1038/leu.2008.346

URL : http://www.nature.com/leu/journal/v23/n4/pdf/leu2008346a.pdf

V. Goede, K. Fischer, R. Busch, A. Engelke, B. Eichhorst et al., Obinutuzumab plus chlorambucil in patients with CLL and coexisting conditions, N. Engl. J. Med, vol.370, pp.1101-1110, 2014.
DOI : 10.1056/nejmoa1313984

V. Goede, K. Fischer, A. Engelke, R. Schlag, S. Lepretre et al., Obinutuzumab as frontline treatment of chronic lymphocytic leukemia: updated results of the CLL11 study, Leukemia, vol.29, pp.1602-1604, 2015.

R. Goldman, Z. Bar-shavit, R. , and D. , Neurotensin modulates human neutrophil locomotion and phagocytic capability, FEBS Lett, vol.159, pp.63-67, 1983.
DOI : 10.1016/0014-5793(83)80417-7

URL : http://onlinelibrary.wiley.com/doi/10.1016/0014-5793(83)80417-7/pdf

Y. Gong, P. Cao, H. Yu, J. , and T. , Crystal structure of the neurotrophin-3 and p75NTR symmetrical complex, Nature, vol.454, pp.789-793, 2008.

D. Gottardi, A. Alfarano, A. M. De-leo, A. Stacchini, M. Aragno et al., In leukaemic CD5+ B cells the ABBACI Amazigh | Thèse de doctorat | Université de Limoges | 2017 204 expression of BCL-2 gene family is shifted toward protection from apoptosis, Br. J. Haematol, vol.94, pp.612-618, 1996.

R. Götz, R. Köster, C. Winkler, F. Raulf, F. Lottspeich et al., Neurotrophin-6 is a new member of the nerve growth factor family, Nature, vol.372, pp.266-269, 1994.

J. G. Gribben and S. Brien, Update on therapy of chronic lymphocytic leukemia, J. Clin. Oncol. Off. J. Am. Soc. Clin. Oncol, vol.29, pp.544-550, 2011.

C. S. Gricks, D. Zahrieh, A. J. Zauls, G. Gorgun, D. Drandi et al., Differential regulation of gene expression following CD40 activation of leukemic compared to healthy B cells, Blood, vol.104, pp.4002-4009, 2004.

P. M. Grob, A. H. Ross, H. Koprowski, and M. Bothwell, Characterization of the human melanoma nerve growth factor receptor, J. Biol. Chem, vol.260, pp.8044-8049, 1985.

A. Guarini, M. Marinelli, S. Tavolaro, E. Bellacchio, M. Magliozzi et al., ATM gene alterations in chronic lymphocytic leukemia patients induce a distinct gene expression profile and predict disease progression, Haematologica, vol.97, pp.47-55, 2012.
DOI : 10.3324/haematol.2011.049270

URL : http://www.haematologica.org/content/haematol/97/1/47.full.pdf

S. Guha, O. Rey, R. , and E. , Neurotensin induces protein kinase Cdependent protein kinase D activation and DNA synthesis in human pancreatic carcinoma cell line PANC-1, Cancer Res, vol.62, pp.1632-1640, 2002.

S. Guha, J. A. Lunn, C. Santiskulvong, R. , and E. , Neurotensin stimulates protein kinase C-dependent mitogenic signaling in human pancreatic carcinoma cell line PANC-1, Cancer Res, vol.63, pp.2379-2387, 2003.

X. Gui, G. Guzman, P. R. Dobner, and S. S. Kadkol, Increased neurotensin receptor-1 expression during progression of colonic adenocarcinoma, Peptides, vol.29, pp.1609-1615, 2008.
DOI : 10.1016/j.peptides.2008.04.014

D. Gully, M. Canton, R. Boigegrain, F. Jeanjean, J. C. Molimard et al., Biochemical and pharmacological profile of a potent and selective nonpeptide antagonist of the neurotensin receptor, Proc. Natl. Acad. Sci. U. S. A, vol.90, pp.65-69, 1993.

D. Gully, B. Labeeuw, R. Boigegrain, F. Oury-donat, A. Bachy et al., Biochemical and Pharmacological Activities of SR 142948A, a New Potent Neurotensin Receptor Antagonist, J. Pharmacol. Exp. Ther, vol.280, pp.802-812, 1997.

A. Haapasalo, I. Sipola, K. Larsson, K. E. Akerman, P. Stoilov et al., Regulation of TRKB surface expression by brain-derived neurotrophic factor and truncated TRKB isoforms, J. Biol. Chem, vol.277, pp.43160-43167, 2002.
DOI : 10.1074/jbc.m205202200

URL : http://www.jbc.org/content/277/45/43160.full.pdf

C. Haase, R. Bergmann, J. Oswald, D. Zips, P. et al., Neurotensin Receptors in Adeno-and Squamous Cell Carcinoma, Anticancer Res, vol.26, pp.3527-3533, 2006.

F. Hagemeister, Rituximab for the treatment of non-Hodgkin's lymphoma and chronic lymphocytic leukaemia, Drugs, vol.70, pp.261-272, 2010.

M. Hallek, Chronic lymphocytic leukemia: 2013 update on diagnosis, risk stratification and treatment, Am. J. Hematol, vol.88, pp.803-816, 2013.

M. Hallek, Chronic lymphocytic leukemia: 2015 Update on diagnosis, risk stratification, and treatment, Am. J. Hematol, vol.90, pp.446-460, 2015.

M. Hallek, P. , and N. , State of the art treatment of chronic lymphocytic leukaemia, Blood Rev, vol.25, pp.1-9, 2011.

M. Hallek, L. Wanders, S. Strohmeyer, and B. Emmerich, Thymidine kinase: a tumor marker with prognostic value for non-Hodgkin's lymphoma and a broad range of potential clinical applications, Ann. Hematol, vol.65, pp.1-5, 1992.

M. Hallek, I. Langenmayer, C. Nerl, W. Knauf, H. Dietzfelbinger et al., Elevated serum thymidine kinase levels identify a subgroup at high risk of disease progression in early, nonsmoldering chronic lymphocytic leukemia, Blood, vol.93, pp.1732-1737, 1999.

M. Hallek, B. D. Cheson, D. Catovsky, F. Caligaris-cappio, G. Dighiero et al., Guidelines for the diagnosis and treatment of chronic lymphocytic leukemia: a report from the International Workshop on Chronic Lymphocytic Leukemia updating the National Cancer InstituteWorking Group 1996 guidelines, Blood, vol.111, pp.5446-5456, 2008.

M. Hallek, K. Fischer, G. Fingerle-rowson, A. M. Fink, R. Busch et al., Addition of rituximab to fludarabine and cyclophosphamide in patients with chronic lymphocytic leukaemia: a randomised, open-label, Lancet Lond. Engl, vol.376, pp.1164-1174, 2010.

M. Hamanoue, G. Middleton, S. Wyatt, E. Jaffray, R. T. Hay et al., p75-mediated NF-kappaB activation enhances the survival response of developing sensory neurons to nerve growth factor, Mol. Cell. Neurosci, vol.14, pp.28-40, 1999.

T. J. Hamblin, Z. Davis, A. Gardiner, D. G. Oscier, and F. K. Stevenson, Unmutated Ig V(H) genes are associated with a more aggressive form of chronic lymphocytic leukemia, Blood, vol.94, pp.1848-1854, 1999.

R. A. Hammer, S. E. Leeman, R. Carraway, W. , and R. H. , Isolation of human intestinal neurotensin, J. Biol. Chem, vol.255, pp.2476-2480, 1980.

M. Hanada, D. Delia, A. Aiello, E. Stadtmauer, R. et al., bcl-2 gene hypomethylation and high-level expression in B-cell chronic lymphocytic leukemia, Blood, vol.82, pp.1820-1828, 1993.

J. Hannestad, F. Marino, A. Germanà, S. Catania, F. Abbate et al., Trk neurotrophin receptor-like proteins in the teleost Dicentrarchus labrax, Cell Tissue Res, vol.300, pp.1-9, 2000.

P. A. Hantzopoulos, C. Suri, D. J. Glass, M. P. Goldfarb, Y. et al., , 1994.

, The low affinity NGF receptor, p75, can collaborate with each of the Trks to potentiate functional responses to the neurotrophins, Neuron, vol.13, pp.187-201

N. L. Harris, E. S. Jaffe, J. Diebold, G. Flandrin, H. K. Muller-hermelink et al., World Health Organization classification of neoplastic diseases of the hematopoietic and lymphoid tissues: report of the Clinical Advisory Committee meeting-Airlie House, J. Clin. Oncol. Off. J. Am. Soc. Clin. Oncol, vol.17, pp.3835-3849, 1997.

Y. Herishanu, P. Pérez-galán, D. Liu, A. Biancotto, S. Pittaluga et al., The lymph node microenvironment promotes B-cell receptor signaling, NF-kappaB activation, and tumor proliferation in chronic lymphocytic leukemia, Blood, vol.117, pp.563-574, 2011.

E. Hermans, A. P. Jeanjean, P. M. Laduron, J. N. Octave, and J. M. Maloteaux, , 1993.

, Postnatal ontogeny of the rat brain neurotensin receptor mRNA, Neurosci. Lett, vol.157, pp.45-48

I. Hermans-borgmeyer, G. Hermey, A. Nykjaer, and C. Schaller, Expression of the 100-kDa neurotensin receptor sortilin during mouse embryonal development, Brain Res. Mol. Brain Res, vol.65, pp.216-219, 1999.

G. Hermey, I. B. Riedel, W. Hampe, H. C. Schaller, and I. Hermans-borgmeyer, Identification and characterization of SorCS, a third member of a novel receptor family, Biochem. Biophys. Res. Commun, vol.266, pp.347-351, 1999.

K. Herrup and E. M. Shooter, Properties of the beta nerve growth factor receptor of avian dorsal root ganglia, Proc. Natl. Acad. Sci. U. S. A, vol.70, pp.3884-3888, 1973.

H. Higuchi, T. Yamashita, H. Yoshikawa, and M. Tohyama, PKA phosphorylates the p75 receptor and regulates its localization to lipid rafts, EMBO J, vol.22, pp.1790-1800, 2003.

J. Hillis, M. O'dwyer, and A. M. Gorman, Neurotrophins and B-cell malignancies, Cell. Mol. Life Sci. CMLS, vol.73, pp.41-56, 2016.

J. P. Hobson, H. M. Rosenfeldt, L. S. Barak, A. Olivera, S. Poulton et al., Role of the sphingosine-1-phosphate receptor EDG-1 in PDGFinduced cell motility, Science, vol.291, pp.1800-1803, 2001.

J. Hoellenriegel, S. A. Meadows, M. Sivina, W. G. Wierda, H. Kantarjian et al.,

N. Giese, S. O'brien, A. Yu, and L. L. Miller, The phosphoinositide 3'-kinase delta inhibitor, CAL-101, inhibits B-cell receptor signaling and chemokine networks in chronic lymphocytic leukemia, Blood, vol.118, pp.3603-3612, 2011.

J. Hoellenriegel, G. P. Coffey, U. Sinha, A. Pandey, M. Sivina et al.,

W. G. Wierda, S. O'brien, and M. J. Keating, Selective, novel spleen tyrosine kinase (Syk) inhibitors suppress chronic lymphocytic leukemia B-cell activation and migration, Leukemia, vol.26, pp.1576-1583, 2012.

M. Holgado-madruga, D. K. Moscatello, D. R. Emlet, R. Dieterich, and A. J. Wong, , 1997.

, Grb2-associated binder-1 mediates phosphatidylinositol 3-kinase activation and the promotion of cell survival by nerve growth factor, Proc. Natl. Acad. Sci. U. S. A, vol.94, pp.12419-12424

E. J. Huang and L. F. Reichardt, Trk receptors: roles in neuronal signal transduction, Annu. Rev. Biochem, vol.72, pp.609-642, 2003.

D. Huhn, C. Schilling, M. Wilhelm, A. D. Ho, M. Hallek et al., Rituximab therapy of patients with B-cell chronic lymphocytic leukemia, Blood, vol.98, pp.1326-1331, 2001.

S. Ibrahim, M. Keating, K. A. Do, S. O'brien, Y. O. Huh et al., CD38 expression as an important prognostic factor in B-cell chronic lymphocytic leukemia, Blood, vol.98, pp.181-186, 2001.

A. Iguchi, H. Matsunaga, T. Nomura, M. Gotoh, and N. Sakamoto, Glucoregulatory effects of intrahypothalamic injections of bombesin and other peptides, Endocrinology, vol.114, pp.2242-2246, 1984.

N. Y. Ip, C. F. Ibáñez, S. H. Nye, J. Mcclain, P. F. Jones et al., Mammalian neurotrophin-4: structure, chromosomal localization, tissue distribution, and receptor specificity, Proc. Natl. Acad. Sci. U. S. A, vol.89, pp.3060-3064, 1992.

Y. Itoh, T. Joh, S. Tanida, M. Sasaki, H. Kataoka et al., IL-8 promotes cell proliferation and migration through metalloproteinase-cleavage proHB-EGF in human colon carcinoma cells, Cytokine, vol.29, pp.275-282, 2005.

L. L. Iversen, S. D. Iversen, F. Bloom, C. Douglas, M. Brown et al., , 1978.

, Calcium-dependent release of somatostatin and neurotensin from rat brain in vitro, Nature, vol.273, pp.161-163

Y. Iwakura, H. Nawa, I. Sora, and M. V. Chao, Dopamine D1 receptor-induced signaling through TrkB receptors in striatal neurons, J. Biol. Chem, vol.283, pp.15799-15806, 2008.

L. Jacobsen, P. Madsen, S. K. Moestrup, A. H. Lund, N. Tommerup et al., Molecular characterization of a novel human hybrid-type receptor that binds the alpha2-macroglobulin receptor-associated protein, J. Biol. Chem, vol.271, pp.31379-31383, 1996.

P. Jansen, K. Giehl, J. R. Nyengaard, K. Teng, O. Lioubinski et al., Roles for the pro-neurotrophin receptor sortilin in neuronal development, aging and brain injury, Nat. Neurosci, vol.10, pp.1449-1457, 2007.
DOI : 10.1038/nn2000

D. F. Jelinek, R. C. Tschumper, S. M. Geyer, N. D. Bone, G. W. Dewald et al., Analysis of clonal B-cell CD38 and immunoglobulin variable region sequence status in relation to clinical outcome for Bchronic lymphocytic leukaemia, Br. J. Haematol, vol.115, pp.854-861, 2001.

R. Jitschin, M. Braun, M. Qorraj, D. Saul, K. Le-blanc et al., Stromal cell-mediated glycolytic switch in CLL cells involves Notch-c-Myc signaling, Blood, vol.125, pp.3432-3436, 2015.
DOI : 10.1182/blood-2014-10-607036

URL : http://www.bloodjournal.org/content/bloodjournal/125/22/3432.full.pdf

O. Johansson and J. Folan, Ultrastructural immunocytochemical studies on CCKand neurotensin-like immunoreactivity in the nucleus accumbens of the rat, Med. Biol, vol.62, pp.318-322, 1984.

D. Johnson, A. Lanahan, C. R. Buck, A. Sehgal, C. Morgan et al., Expression and structure of the human NGF receptor, Cell, vol.47, pp.545-554, 1986.
DOI : 10.1016/0092-8674(86)90619-7

G. Juliusson, D. G. Oscier, M. Fitchett, F. M. Ross, G. Stockdill et al., Prognostic subgroups in B-cell chronic lymphocytic leukemia defined by specific chromosomal abnormalities, N. Engl. J. Med, vol.323, pp.720-724, 1990.
DOI : 10.1056/nejm199009133231105

R. Kaaks, D. Sookthai, A. ?uczy?ska, C. C. Oakes, S. Becker et al., Lag times between lymphoproliferative disorder and clinical diagnosis of chronic lymphocytic leukemia: a prospective analysis using plasma soluble CD23, Cancer Epidemiol. Biomark. Prev. Publ. Am. Assoc. Cancer Res. Cosponsored Am. Soc. Prev. Oncol, vol.24, pp.538-545, 2015.
DOI : 10.1158/1055-9965.epi-14-1107

T. Kadia, M. L. Delioukina, H. M. Kantarjian, M. J. Keating, W. G. Wierda et al., A Pilot Phase II Study of the Lyn Kinase Inhibitor Bafetinib in Patients with Relapsed or Refractory B Cell Chronic Lymphocytic Leukemia, Blood, vol.118, pp.2858-2858, 2011.

S. Kamimae, E. Yamamoto, M. Kai, T. Niinuma, H. Yamano et al., Epigenetic silencing of NTSR1 is associated with lateral and noninvasive growth of colorectal tumors, Oncotarget, vol.6, pp.29975-29990, 2015.
DOI : 10.18632/oncotarget.5034

URL : http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=download&path%5B%5D=5034&path%5B%5D=11988

K. C. Kanning, M. Hudson, P. S. Amieux, J. C. Wiley, M. Bothwell et al., Proteolytic processing of the p75 neurotrophin receptor and two homologs generates C-terminal fragments with signaling capability, J. Neurosci. Off. J. Soc. Neurosci, vol.23, pp.5425-5436, 2003.

S. Kao, R. K. Jaiswal, W. Kolch, and G. E. Landreth, Identification of the mechanisms regulating the differential activation of the mapk cascade by epidermal growth factor and nerve growth factor in PC12 cells, J. Biol. Chem, vol.276, pp.18169-18177, 2001.

N. E. Kay, S. M. O'brien, A. R. Pettitt, and S. Stilgenbauer, The role of prognostic factors in assessing "high-risk" subgroups of patients with chronic lymphocytic leukemia, Leukemia, vol.21, pp.1885-1891, 2007.

M. J. Keating, I. Flinn, V. Jain, J. Binet, P. Hillmen et al., Therapeutic role of alemtuzumab (Campath-1H) in patients who have failed fludarabine: results of a large international study, Blood, vol.99, pp.3554-3561, 2002.

S. J. Keely, S. O. Calandrella, and K. E. Barrett, Carbachol-stimulated transactivation of epidermal growth factor receptor and mitogen-activated protein kinase in T(84) cells is mediated by intracellular Ca2+, PYK-2, and p60(src), J. Biol. Chem, vol.275, pp.12619-12625, 2000.

J. H. Kehrl, Heterotrimeric G protein signaling: roles in immune function and finetuning by RGS proteins, Immunity, vol.8, pp.1-10, 1998.
DOI : 10.1016/s1074-7613(00)80453-7

URL : https://doi.org/10.1016/s1074-7613(00)80453-7

J. H. Kehrl, The impact of RGS and other G-protein regulatory proteins on G?imediated signaling in immunity, Biochem. Pharmacol, vol.114, pp.40-52, 2016.

M. Kerschensteiner, E. Gallmeier, L. Behrens, V. V. Leal, T. Misgeld et al., Activated human T cells, B cells, and monocytes produce brain-derived neurotrophic factor in vitro and in inflammatory brain lesions: a neuroprotective role of inflammation?, J. Exp. Med, vol.189, pp.865-870, 1999.

G. Khursigara, J. R. Orlinick, and M. V. Chao, Association of the p75 neurotrophin receptor with TRAF6, J. Biol. Chem, vol.274, pp.2597-2600, 1999.

Y. Kikushige, F. Ishikawa, T. Miyamoto, T. Shima, S. Urata et al., Self-renewing hematopoietic stem cell is the primary target in pathogenesis of human chronic lymphocytic leukemia, Cancer Cell, vol.20, pp.246-259, 2011.

H. S. Kim, S. Yumkham, J. H. Choi, S. H. Lee, T. Kim et al., Neurotensin enhances nitric oxide generation via the JAK2-STAT1 pathway in murine macrophage Raw264.7 cells during costimulation with LPS and IFNgamma, Neuropeptides, vol.40, pp.221-229, 2006.
DOI : 10.1016/j.npep.2006.01.001

J. T. Kim, C. Liu, Y. Y. Zaytseva, H. L. Weiss, C. M. Townsend et al., , 2015.

. Neurotensin, Wnt/?-catenin pathway, promotes growth of neuroendocrine tumor cells, Int. J. Cancer, vol.136, pp.1475-1481

J. T. Kim, J. Li, J. Song, E. Y. Lee, H. L. Weiss et al., , 2015.

, Differential expression and tumorigenic function of neurotensin receptor 1 in neuroendocrine tumor cells, Oncotarget, vol.6, pp.26960-26970

J. T. Kim, H. L. Weiss, and B. M. Evers, Diverse expression patterns and tumorigenic role of neurotensin signaling components in colorectal cancer cells, Int. J. Oncol, vol.50, pp.2200-2206, 2017.

M. J. Kim, E. Kim, S. H. Ryu, and P. G. Suh, The mechanism of phospholipase Cgamma1 regulation, Exp. Mol. Med, vol.32, pp.101-109, 2000.

M. T. Kimura, S. Irie, S. Shoji-hoshino, J. Mukai, D. Nadano et al., 14-3-3 is involved in p75 neurotrophin receptor-mediated signal transduction, J. Biol. Chem, vol.276, pp.17291-17300, 2001.
DOI : 10.1074/jbc.m005453200

URL : http://www.jbc.org/content/276/20/17291.full.pdf

T. J. Kipps, W. G. Wierda, J. A. Jones, L. J. Swinnen, J. Yang et al., , 2010.

. Fludarabine/cyclophosphamide/rituximab, FCR) or Bendamustine/Rituximab (BR): A Phase 1 Study In Patients with Relapsed/Refractory Chronic Lymphocytic Leukemia (CLL), Blood, vol.116, pp.2455-2455

T. J. Kipps, H. Eradat, S. Grosicki, J. Catalano, W. Cosolo et al., A phase 2 study of the BH3 mimetic BCL2 inhibitor navitoclax (ABT-263) with or without rituximab, in previously untreated B-cell chronic lymphocytic leukemia, Leuk. Lymphoma, vol.56, pp.2826-2833, 2015.

T. J. Kipps, F. K. Stevenson, C. J. Wu, C. M. Croce, G. Packham et al., Chronic lymphocytic leukaemia, Nat. Rev. Dis. Primer, vol.3, p.16096, 2017.

K. Kisfalvi, C. Hurd, S. Guha, R. , and E. , Induced overexpression of protein kinase D1 stimulates mitogenic signaling in human pancreatic carcinoma PANC-1 cells, J. Cell. Physiol, vol.223, pp.309-316, 2010.

E. Kislauskis, B. Bullock, S. Mcneil, and P. R. Dobner, The rat gene encoding neurotensin and neuromedin N. Structure, tissue-specific expression, and evolution of exon sequences, J. Biol. Chem, vol.263, pp.4963-4968, 1988.

P. Kitabgi, Targeting neurotensin receptors with agonists and antagonists for therapeutic purposes, Curr. Opin. Drug Discov. Devel, vol.5, pp.764-776, 2002.

P. Kitabgi, Differential processing of pro-neurotensin/neuromedin N and relationship to pro-hormone convertases, Peptides, vol.27, pp.2508-2514, 2006.

P. Kitabgi, Inactivation of neurotensin and neuromedin N by Zn metallopeptidases, Peptides, vol.27, pp.2515-2522, 2006.
DOI : 10.1016/j.peptides.2005.12.017

P. Kitabgi, Neurotensin and neuromedin N are differentially processed from a common precursor by prohormone convertases in tissues and cell lines, Results Probl. Cell Differ, vol.50, pp.85-96, 2010.
DOI : 10.1007/400_2009_27

P. Kitabgi, R. Carraway, and S. E. Leeman, Isolation of a tridecapeptide from bovine intestinal tissue and its partial characterization as neurotensin, J. Biol. Chem, vol.251, pp.7053-7058, 1976.

P. Kitabgi, R. Carraway, J. Van-rietschoten, C. Granier, J. L. Morgat et al., Neurotensin: specific binding to synaptic membranes from rat brain, Proc. Natl. Acad. Sci. U. S. A, vol.74, pp.1846-1850, 1977.
DOI : 10.1073/pnas.74.5.1846

URL : http://www.pnas.org/content/74/5/1846.full.pdf

P. Kitabgi, C. Y. Kwan, J. E. Fox, and J. P. Vincent, Characterization of neurotensin binding to rat gastric smooth muscle receptor sites, Peptides, vol.5, pp.917-923, 1984.
DOI : 10.1016/0196-9781(84)90117-7

P. Kitabgi, W. Rostène, M. Dussaillant, A. Schotte, P. M. Laduron et al., Two populations of neurotensin binding sites in murine brain: discrimination by the antihistamine levocabastine reveals markedly different radioautographic distribution, Eur. J. Pharmacol, vol.140, pp.285-293, 1987.

P. Kitabgi, F. De-nadai, C. Rovère, and J. N. Bidard, Biosynthesis, maturation, release, and degradation of neurotensin and neuromedin N, Ann. N. Y. Acad. Sci, vol.668, pp.30-42, 1992.

S. Kitada, J. Andersen, S. Akar, J. M. Zapata, S. Takayama et al., Expression of apoptosis-regulating proteins in chronic lymphocytic leukemia: correlations with In vitro and In vivo chemoresponses, Blood, vol.91, pp.3379-3389, 1998.

S. Kitada, I. M. Pedersen, A. D. Schimmer, R. , and J. C. , Dysregulation of apoptosis genes in hematopoietic malignancies, Oncogene, vol.21, pp.3459-3474, 2002.
DOI : 10.1038/sj.onc.1205327

URL : http://www.nature.com/onc/journal/v21/n21/pdf/1205327a.pdf

R. Klein, S. Q. Jing, V. Nanduri, E. O'rourke, and M. Barbacid, The trk protooncogene encodes a receptor for nerve growth factor, Cell, vol.65, pp.189-197, 1991.
DOI : 10.1016/0092-8674(91)90419-y

R. Klein, V. Nanduri, S. A. Jing, F. Lamballe, P. Tapley et al., The trkB tyrosine protein kinase is a receptor for brain-derived neurotrophic factor and neurotrophin-3, Cell, vol.66, pp.395-403, 1991.
DOI : 10.1016/0092-8674(91)90628-c

W. U. Knauf, T. Lissichkov, A. Aldaoud, A. Liberati, J. Loscertales et al., Phase III randomized study of bendamustine compared with chlorambucil in previously untreated patients with chronic lymphocytic leukemia, J. Clin. Oncol. Off. J. Am. Soc. Clin. Oncol, vol.27, pp.4378-4384, 2009.

H. Kobayashi, G. J. Gleich, J. H. Butterfield, and H. Kita, Human eosinophils produce neurotrophins and secrete nerve growth factor on immunologic stimuli, Blood, vol.99, pp.2214-2220, 2002.
DOI : 10.1182/blood.v99.6.2214

H. Kong, J. Boulter, J. L. Weber, C. Lai, and M. V. Chao, An evolutionarily conserved transmembrane protein that is a novel downstream target of neurotrophin and ephrin receptors, J. Neurosci. Off. J. Soc. Neurosci, vol.21, pp.176-185, 2001.
DOI : 10.1523/jneurosci.21-01-00176.2001

URL : http://www.jneurosci.org/content/21/1/176.full.pdf

H. Koon, Y. S. Kim, H. Xu, A. Kumar, D. Zhao et al., Neurotensin induces IL-6 secretion in mouse preadipocytes and adipose tissues during 2,4,6,-trinitrobenzensulphonic acid-induced colitis, Proc. Natl. Acad. Sci. U. S. A, vol.106, pp.8766-8771, 2009.
DOI : 10.1073/pnas.0903499106

URL : http://www.pnas.org/content/106/21/8766.full.pdf

S. A. Kotecha, J. N. Oak, M. F. Jackson, Y. Perez, B. A. Orser et al., A D2 class dopamine receptor transactivates a receptor tyrosine kinase to inhibit NMDA receptor transmission, Neuron, vol.35, pp.1111-1122, 2002.
DOI : 10.1016/s0896-6273(02)00859-0

URL : https://doi.org/10.1016/s0896-6273(02)00859-0

M. Krajewska, S. Krajewski, J. M. Zapata, T. Van-arsdale, R. D. Gascoyne et al., TRAF-4 expression in epithelial progenitor cells. Analysis in normal adult, fetal, and tumor tissues, Am. J. Pathol, vol.152, pp.1549-1561, 1998.

K. D. Kreitel, C. B. Swisher, and M. M. Behbehani, The effects of diphenhydramine and SR142948A on periaqueductal gray neurons and on the interactions between the medial preoptic nucleus and the periaqueductal gray, Neuroscience, vol.114, pp.935-943, 2002.

A. Kröber, T. Seiler, A. Benner, L. Bullinger, E. Brückle et al., V(H) mutation status, CD38 expression level, genomic aberrations, and survival in chronic lymphocytic leukemia, Blood, vol.100, pp.1410-1416, 2002.

A. Kröber, J. Bloehdorn, S. Hafner, A. Bühler, T. Seiler et al., Additional genetic high-risk features such as 11q deletion, 17p deletion, and V3-21 usage characterize discordance of ZAP-70 and VH mutation status in chronic lymphocytic leukemia, J. Clin. Oncol. Off. J. Am. Soc. Clin. Oncol, vol.24, pp.969-975, 2006.

I. Kronfeld, G. Kazimirsky, E. W. Gelfand, B. , and C. , NGF rescues human B lymphocytes from anti-IgM induced apoptosis by activation of PKCzeta, Eur. J. Immunol, vol.32, pp.136-143, 2002.
DOI : 10.1002/1521-4141(200201)32:1<136::aid-immu136>3.0.co;2-t

URL : https://onlinelibrary.wiley.com/doi/pdf/10.1002/1521-4141%28200201%2932%3A1%3C136%3A%3AAID-IMMU136%3E3.0.CO%3B2-T

D. Kryl and P. A. Barker, TTIP is a novel protein that interacts with the truncated T1 TrkB neurotrophin receptor, Biochem. Biophys. Res. Commun, vol.279, pp.925-930, 2000.
DOI : 10.1006/bbrc.2000.4058

T. Kurosaki, Regulation of B-cell signal transduction by adaptor proteins, Nat. Rev. Immunol, vol.2, pp.354-363, 2002.
DOI : 10.1038/nri801

R. Kuruvilla, H. Ye, and D. D. Ginty, Spatially and functionally distinct roles of the PI3-K effector pathway during NGF signaling in sympathetic neurons, Neuron, vol.27, pp.499-512, 2000.

C. Labbé-jullié, J. M. Botto, M. V. Mas, J. Chabry, J. Mazella et al., the first nonpeptide neurotensin antagonist radioligand: characterization of binding properties and evidence for distinct agonist and antagonist binding domains on the rat neurotensin receptor, vol.47, pp.1050-1056, 1995.

C. Labbé-jullié, S. Barroso, D. Nicolas-etève, J. L. Reversat, J. M. Botto et al., Mutagenesis and modeling of the neurotensin receptor NTR1. Identification of residues that are critical for binding SR 48692, a nonpeptide neurotensin antagonist, J. Biol. Chem, vol.273, pp.16351-16357, 1998.

E. Labouyrie, P. Dubus, A. Groppi, F. X. Mahon, J. Ferrer et al.,

A. Mascarel and J. P. Merlio, Expression of neurotrophins and their receptors in human bone marrow, Am. J. Pathol, vol.154, pp.405-415, 1999.

L. Lagneaux, A. Delforge, C. Dorval, D. Bron, and P. Stryckmans, Excessive production of transforming growth factor-beta by bone marrow stromal cells in B-cell chronic lymphocytic leukemia inhibits growth of hematopoietic precursors and interleukin-6 production, Blood, vol.82, pp.2379-2385, 1993.

L. Lagneaux, A. Delforge, D. Bron, C. De-bruyn, and P. Stryckmans, Chronic lymphocytic leukemic B cells but not normal B cells are rescued from apoptosis by contact with normal bone marrow stromal cells, Blood, vol.91, pp.2387-2396, 1998.

F. Lamballe, R. Klein, and M. Barbacid, trkC, a new member of the trk family of tyrosine protein kinases, is a receptor for neurotrophin-3, Cell, vol.66, pp.967-979, 1991.

M. C. Lanasa, Novel insights into the biology of CLL, Hematol. Am. Soc. Hematol. Educ. Program, pp.70-76, 2010.

R. Lapalombella, L. Andritsos, Q. Liu, S. E. May, R. Browning et al., Lenalidomide treatment promotes CD154 expression on CLL cells and enhances production of antibodies by normal B cells through a PI3-kinase-dependent pathway, Blood, vol.115, pp.2619-2629, 2010.

T. H. Large, G. Weskamp, J. C. Helder, M. J. Radeke, T. P. Misko et al., Structure and developmental expression of the nerve growth factor receptor in the chicken central nervous system, Neuron, vol.2, pp.1123-1134, 1989.

P. Laurent, P. Clerc, M. G. Mattei, P. Forgez, X. Dumont et al., Chromosomal localization of mouse and human neurotensin receptor genes, Mamm. Genome Off. J. Int. Mamm. Genome Soc, vol.5, pp.303-306, 1994.

F. Le, K. Groshan, X. P. Zeng, R. , and E. , Characterization of the genomic structure, promoter region, and a tetranucleotide repeat polymorphism of the human neurotensin receptor gene, J. Biol. Chem, vol.272, pp.1315-1322, 1997.

F. S. Lee and M. V. Chao, Activation of Trk neurotrophin receptors in the absence of neurotrophins, Proc. Natl. Acad. Sci. U. S. A, vol.98, pp.3555-3560, 2001.

F. S. Lee, R. Rajagopal, and M. V. Chao, Distinctive features of Trk neurotrophin receptor transactivation by G protein-coupled receptors, Cytokine Growth Factor Rev, vol.13, pp.11-17, 2002.

F. S. Lee, R. Rajagopal, A. H. Kim, P. C. Chang, and M. V. Chao, Activation of Trk neurotrophin receptor signaling by pituitary adenylate cyclase-activating polypeptides, J. Biol. Chem, vol.277, pp.9096-9102, 2002.

R. Lee, P. Kermani, K. K. Teng, and B. L. Hempstead, Regulation of cell survival by secreted proneurotrophins, Science, vol.294, pp.1945-1948, 2001.

S. Lefrancois, J. Zeng, A. J. Hassan, M. Canuel, and C. R. Morales, The lysosomal trafficking of sphingolipid activator proteins (SAPs) is mediated by sortilin, EMBO J, vol.22, pp.6430-6437, 2003.

I. Lemaire, Neurotensin enhances IL-1 production by activated alveolar macrophages, J. Immunol. Baltim. Md, vol.140, pp.2983-2988, 1950.

A. Leon, A. Buriani, R. Dal-toso, M. Fabris, S. Romanello et al., Mast cells synthesize, store, and release nerve growth factor, Proc. Natl. Acad. Sci. U. S. A, vol.91, pp.3739-3743, 1994.

M. Leporrier, S. Chevret, B. Cazin, N. Boudjerra, P. Feugier et al., Randomized comparison of fludarabine, CAP, and ChOP in 938 previously untreated stage B and C chronic lymphocytic leukemia patients, Blood, vol.98, pp.2319-2325, 2001.

S. Lepretre and É. V. Neste, Place de la chimiothérapie dans la leucémie lymphoïde chronique, Hématologie, vol.12, pp.28-34, 2006.

V. Lessmann and T. Brigadski, Mechanisms, locations, and kinetics of synaptic BDNF secretion: an update, Neurosci. Res, vol.65, pp.11-22, 2009.

V. Lessmann, K. Gottmann, and M. Malcangio, Neurotrophin secretion: current facts and future prospects, Prog. Neurobiol, vol.69, pp.341-374, 2003.
DOI : 10.1016/s0301-0082(03)00019-4

R. Levi-montalcini and S. Cohen, VITRO AND IN VIVO EFFECTS OF A NERVE GROWTH-STIMULATING AGENT ISOLATED FROM SNAKE VENOM, vol.42, pp.695-699, 1956.

R. Levi-montalcini and V. Hamburger, Selective growth stimulating effects of mouse sarcoma on the sensory and sympathetic nervous system of the chick embryo, J. Exp. Zool, vol.116, pp.321-361, 1951.

Z. Li, Z. Chang, L. J. Chiao, Y. Kang, Q. Xia et al., TrkBT1 induces liver metastasis of pancreatic cancer cells by sequestering Rho GDP dissociation inhibitor and promoting RhoA activation, Cancer Res, vol.69, pp.7851-7859, 2009.
DOI : 10.1158/0008-5472.can-08-4002

URL : http://cancerres.aacrjournals.org/content/canres/69/19/7851.full.pdf

Z. Li, G. Beutel, M. Rhein, J. Meyer, C. Koenecke et al., High-affinity neurotrophin receptors and ligands promote leukemogenesis, Blood, vol.113, pp.2028-2037, 2009.
DOI : 10.1182/blood-2008-05-155200

URL : http://www.bloodjournal.org/content/bloodjournal/113/9/2028.full.pdf

M. S. Linet, M. L. Van-natta, R. Brookmeyer, M. J. Khoury, L. D. Mccaffrey et al., Familial cancer history and chronic lymphocytic leukemia. A case-control study, Am. J. Epidemiol, vol.130, pp.655-664, 1989.

Y. Liu, S. An, R. Ward, Y. Yang, X. Guo et al., G proteincoupled receptors as promising cancer targets, Cancer Lett, vol.376, pp.226-239, 2016.
DOI : 10.1016/j.canlet.2016.03.031

A. D. Loewy and S. Mckellar, The neuroanatomical basis of central cardiovascular control, Fed. Proc, vol.39, pp.2495-2503, 1980.

P. G. Longo, L. Laurenti, S. Gobessi, A. Petlickovski, M. Pelosi et al., The Akt signaling pathway determines the different proliferative capacity of chronic lymphocytic leukemia B-cells from patients with progressive and stable disease, Leukemia, vol.21, pp.110-120, 2007.

P. G. Longo, L. Laurenti, S. Gobessi, S. Sica, G. Leone et al., , 2008.

, Akt/Mcl-1 pathway plays a prominent role in mediating antiapoptotic signals downstream of the B-cell receptor in chronic lymphocytic leukemia B cells, Blood, vol.111, pp.846-855

G. Lozanski, N. A. Heerema, I. W. Flinn, L. Smith, J. Harbison et al., Alemtuzumab is an effective therapy for chronic lymphocytic leukemia with p53 mutations and deletions, Blood, vol.103, pp.3278-3281, 2004.

K. Luberg, J. Wong, C. S. Weickert, and T. Timmusk, Human TrkB gene: novel alternative transcripts, protein isoforms and expression pattern in the prefrontal cerebral cortex during postnatal development, J. Neurochem, vol.113, pp.952-964, 2010.

L. M. Luttrell, B. E. Hawes, T. Van-biesen, D. K. Luttrell, T. J. Lansing et al., Role of c-Src tyrosine kinase in G protein-coupled receptor-and Gbetagamma subunit-mediated activation of mitogen-activated protein kinases, J. Biol. Chem, vol.271, pp.19443-19450, 1996.

J. I. Macdonald and S. O. Meakin, Deletions in the extracellular domain of rat trkA lead to an altered differentiative phenotype in neurotrophin responsive cells, Mol. Cell. Neurosci, vol.7, pp.371-390, 1996.

J. I. Macdonald, E. A. Gryz, C. J. Kubu, J. M. Verdi, and S. O. Meakin, Direct binding of the signaling adapter protein Grb2 to the activation loop tyrosines on the nerve growth factor receptor tyrosine kinase, TrkA. J. Biol. Chem, vol.275, pp.18225-18233, 2000.

H. Maeno, K. Yamada, Y. Santo-yamada, K. Aoki, Y. Sun et al., Comparison of mice deficient in the high-or low-affinity neurotensin receptors, Ntsr1 or Ntsr2, reveals a novel function for Ntsr2 in thermal nociception, Brain Res, vol.998, pp.122-129, 2004.

M. Magazin, E. Poszepczynska-guigné, M. Bagot, L. Boumsell, C. Pruvost et al., Sezary syndrome cells unlike normal circulating T lymphocytes fail to migrate following engagement of NT1 receptor, J. Invest. Dermatol, vol.122, pp.111-118, 2004.

P. C. Maisonpierre, L. Belluscio, B. Friedman, R. F. Alderson, S. J. Wiegand et al., NT-3, BDNF, and NGF in the developing rat nervous system: parallel as well as reciprocal patterns of expression, Neuron, vol.5, pp.501-509, 1990.

J. Malcikova, J. Smardova, L. Rocnova, B. Tichy, P. Kuglik et al., Monoallelic and biallelic inactivation of TP53 gene in chronic lymphocytic leukemia: selection, impact on survival, and response to DNA damage, Blood, vol.114, pp.5307-5314, 2009.

L. Mansouri, N. Cahill, R. Gunnarsson, K. E. Smedby, E. Tjönnfjord et al., NOTCH1 and SF3B1 mutations can be added to the hierarchical prognostic classification in chronic lymphocytic leukemia, Leukemia, vol.27, pp.512-514, 2013.

J. J. Maoret, Y. Anini, C. Rouyer-fessard, D. Gully, L. et al., Neurotensin and a non-peptide neurotensin receptor antagonist control human colon cancer cell growth in cell culture and in cells xenografted into nude mice, Int. J. Cancer, vol.80, pp.448-454, 1999.

I. Marondel, B. Renault, J. Lieman, D. Ward, and R. Kucherlapati, Physical mapping of the human neurotensin gene (NTS) between markers D12S1444 and D12S81 on chromosome 12q21, Genomics, vol.38, pp.243-245, 1996.

R. Marsault and C. Frelin, Activation by nitric oxide of guanylate cyclase in endothelial cells from brain capillaries, J. Neurochem, vol.59, pp.942-945, 1992.

C. J. Marshall, Specificity of receptor tyrosine kinase signaling: transient versus sustained extracellular signal-regulated kinase activation, Cell, vol.80, pp.179-185, 1995.

S. Martin, J. M. Botto, J. P. Vincent, and J. Mazella, Pivotal role of an aspartate residue in sodium sensitivity and coupling to G proteins of neurotensin receptors, Mol. Pharmacol, vol.55, pp.210-215, 1999.

S. Martin, J. Vincent, and J. Mazella, Recycling ability of the mouse and the human neurotensin type 2 receptors depends on a single tyrosine residue, J. Cell Sci, vol.115, pp.165-173, 2002.

S. Martin, J. Vincent, and J. Mazella, Involvement of the neurotensin receptor-3 in the neurotensin-induced migration of human microglia, J. Neurosci. Off. J. Soc. Neurosci, vol.23, pp.1198-1205, 2003.
URL : https://hal.archives-ouvertes.fr/hal-00091093

S. Martin, E. Dicou, J. Vincent, and J. Mazella, Neurotensin and the neurotensin receptor-3 in microglial cells, J. Neurosci. Res, vol.81, pp.322-326, 2005.
URL : https://hal.archives-ouvertes.fr/hal-00094511

A. Martínez-trillos, M. Pinyol, A. Navarro, M. Aymerich, P. Jares et al., Mutations in TLR/MYD88 pathway identify a subset of young chronic lymphocytic leukemia patients with favorable outcome, Blood, vol.123, pp.3790-3796, 2014.

F. Massa, A. Tormo, S. Béraud-dufour, T. Coppola, and J. Mazella, Neurotensininduced Erk1/2 phosphorylation and growth of human colonic cancer cells are independent from growth factors receptors activation, Biochem. Biophys. Res. Commun, vol.414, pp.118-122, 2011.

F. Massa, C. Devader, S. Béraud-dufour, F. Brau, T. Coppola et al., Focal adhesion kinase dependent activation of the PI3 kinase pathway by the functional soluble form of neurotensin receptor-3 in HT29 cells, Int. J. Biochem. Cell Biol, vol.45, pp.952-959, 2013.
URL : https://hal.archives-ouvertes.fr/hal-00855040

F. Massa, C. Devader, S. Lacas-gervais, S. Béraud-dufour, T. Coppola et al., Impairement of HT29 Cancer Cells Cohesion by the Soluble Form of Neurotensin Receptor-3, Genes Cancer, vol.5, pp.240-249, 2014.
URL : https://hal.archives-ouvertes.fr/hal-02108990

C. Matthews, M. A. Catherwood, T. C. Morris, P. J. Kettle, M. B. Drake et al., Serum TK levels in CLL identify Binet stage A patients within biologically defined prognostic subgroups most likely to undergo disease progression, Eur. J. Haematol, vol.77, pp.309-317, 2006.

E. Matutes, K. Owusu-ankomah, R. Morilla, J. Garcia-marco, A. Houlihan et al., The immunological profile of B-cell disorders and proposal of a scoring system for the diagnosis of CLL, Leukemia, vol.8, pp.1640-1645, 1994.

E. Matutes, D. Oscier, J. Garcia-marco, J. Ellis, A. Copplestone et al., Trisomy 12 defines a group of CLL with atypical morphology: correlation between cytogenetic, clinical and laboratory features in 544 patients, Br. J. Haematol, vol.92, pp.382-388, 1996.

J. Mazella and J. Vincent, Internalization and recycling properties of neurotensin receptors, Peptides, vol.27, pp.2488-2492, 2006.
URL : https://hal.archives-ouvertes.fr/hal-00171827

J. Mazella, C. Poustis, C. Labbe, F. Checler, P. Kitabgi et al., Monoiodo-[Trp11]neurotensin, a highly radioactive ligand of neurotensin receptors. Preparation, biological activity, and binding properties to rat brain synaptic membranes, J. Biol. Chem, vol.258, pp.3476-3481, 1983.

J. Mazella, S. Amar, J. C. Bozou, P. Kitabgi, and J. P. Vincent, Functional properties and molecular structure of central and peripheral neurotensin receptors, J. Recept. Res, vol.7, pp.157-165, 1987.
DOI : 10.3109/10799898709054984

J. Mazella, J. Chabry, P. Kitabgi, and J. P. Vincent, Solubilization and characterization of active neurotensin receptors from mouse brain, J. Biol. Chem, vol.263, pp.144-149, 1988.

J. Mazella, J. Chabry, N. Zsurger, and J. P. Vincent, Purification of the neurotensin receptor from mouse brain by affinity chromatography, J. Biol. Chem, vol.264, pp.5559-5563, 1989.

J. Mazella, K. Leonard, J. Chabry, P. Kitabgi, J. P. Vincent et al., Binding and internalization of iodinated neurotensin in neuronal cultures from embryonic mouse brain, Brain Res, vol.564, pp.249-255, 1991.
DOI : 10.1016/0006-8993(91)91460-i

J. Mazella, J. M. Botto, E. Guillemare, T. Coppola, P. Sarret et al., , 1996.

, Structure, functional expression, and cerebral localization of the levocabastine-sensitive neurotensin/neuromedin N receptor from mouse brain, J. Neurosci. Off. J. Soc. Neurosci, vol.16, pp.5613-5620

J. Mazella, J. M. Botto, E. Guillemare, T. Coppola, P. Sarret et al., , 1996.

, Structure, functional expression, and cerebral localization of the levocabastine-sensitive neurotensin/neuromedin N receptor from mouse brain, J. Neurosci. Off. J. Soc. Neurosci, vol.16, pp.5613-5620

J. Mazella, N. Zsürger, V. Navarro, J. Chabry, M. Kaghad et al., The 100-kDa neurotensin receptor is gp95/sortilin, a non-G-protein-coupled receptor, J. Biol. Chem, vol.273, pp.26273-26276, 1998.

D. J. Mcconkey, J. Chandra, S. Wright, W. Plunkett, T. J. Mcdonnell et al., Apoptosis sensitivity in chronic lymphocytic leukemia is determined by endogenous endonuclease content and relative expression of BCL-2 and BAX, J. Immunol, vol.156, pp.2624-2630, 1996.

T. W. Mckeithan, G. S. Takimoto, H. Ohno, V. S. Bjorling, R. Morgan et al., BCL3 rearrangements and t(14;19) in chronic lymphocytic leukemia and other B-cell malignancies: a molecular and cytogenetic study, Genes. Chromosomes Cancer, vol.20, pp.64-72, 1997.

M. Méndez, F. Souazé, M. Nagano, P. A. Kelly, W. Rostène et al., High affinity neurotensin receptor mRNA distribution in rat brain and peripheral tissues, J. Mol. Neurosci. MN, vol.9, pp.93-102, 1997.

B. T. Messmer, D. Messmer, S. L. Allen, J. E. Kolitz, P. Kudalkar et al., In vivo measurements document the dynamic cellular kinetics of chronic lymphocytic leukemia B cells, J. Clin. Invest, vol.115, pp.755-764, 2005.

N. Meuleman, B. Stamatopoulos, M. Dejeneffe, H. El-housni, L. Lagneaux et al., Doubling time of soluble CD23: a powerful prognostic factor for newly diagnosed and untreated stage A chronic lymphocytic leukemia patients, Leukemia, vol.22, pp.1882-1890, 2008.

S. Mi, X. Lee, Z. Shao, G. Thill, B. Ji et al., LINGO-1 is a component of the Nogo-66 receptor/p75 signaling complex, Nat. Neurosci, vol.7, pp.221-228, 2004.

L. Michaux, C. Mecucci, M. Stul, I. Wlodarska, J. M. Hernandez et al., BCL3 rearrangement and t(14;19)(q32;q13) in lymphoproliferative disorders, Genes. Chromosomes Cancer, vol.15, pp.38-47, 1996.

J. Michels, J. W. O&apos;neill, C. L. Dallman, A. Mouzakiti, F. Habens et al., Mcl-1 is required for Akata6 B-lymphoma cell survival and is converted to a cell death molecule by efficient caspase-mediated cleavage, Oncogene, vol.23, pp.4818-4827, 2004.

F. Mignini, M. Sabbatini, V. D&apos;andrea, C. , and C. , Neuropeptides of human thymus in normal and pathological conditions, Peptides, vol.32, pp.920-928, 2011.

T. Mijatovic, P. Gailly, V. Mathieu, N. De-nève, P. Yeaton et al., Neurotensin is a versatile modulator of in vitro human pancreatic ductal adenocarcinoma cell (PDAC) migration, Cell. Oncol. Off. J. Int. Soc. Cell. Oncol, vol.29, pp.315-326, 2007.

N. Minamino, K. Kangawa, and H. Matsuo, Neuromedin N: a novel neurotensin-like peptide identified in porcine spinal cord, Biochem. Biophys. Res. Commun, vol.122, pp.542-549, 1984.

L. Minichiello, M. Korte, D. Wolfer, R. Kühn, K. Unsicker et al., Essential role for TrkB receptors in hippocampus-mediated learning, Neuron, vol.24, pp.401-414, 1999.

E. Mira, R. A. Lacalle, M. A. González, C. Gómez-moutón, J. L. Abad et al., A role for chemokine receptor transactivation in growth factor signaling, EMBO Rep, vol.2, pp.151-156, 2001.

M. Mitre, A. Mariga, and M. V. Chao, Neurotrophin signalling: novel insights into mechanisms and pathophysiology, Clin. Sci. Lond. Engl, vol.131, pp.13-23, 1979.

R. Möhle, C. Failenschmid, F. Bautz, and L. Kanz, Overexpression of the chemokine receptor CXCR4 in B cell chronic lymphocytic leukemia is associated with increased functional response to stromal cell-derived factor-1 (SDF-1), Leukemia, vol.13, pp.1954-1959, 1999.

S. Molica, Infections in chronic lymphocytic leukemia: risk factors, and impact on survival, and treatment, Leuk. Lymphoma, vol.13, pp.203-214, 1994.

S. Molica, Second neoplasms in chronic lymphocytic leukemia: incidence and pathogenesis with emphasis on the role of different therapies, Leuk. Lymphoma, vol.46, pp.49-54, 2005.

S. Molica, D. Levato, M. Dell&apos;olio, R. Matera, M. Minervini et al., Cellular expression and serum circulating levels of CD23 in B-cell chronic lymphocytic leukemia. Implications for prognosis, Haematologica, vol.81, pp.428-433, 1996.

M. Montillo, T. Hamblin, M. Hallek, E. Montserrat, and E. Morra, Chronic lymphocytic leukemia: novel prognostic factors and their relevance for risk-adapted therapeutic strategies, Haematologica, vol.90, pp.391-399, 2005.

E. Montserrat, Role of auto-and allotransplantation in B-cell chronic lymphocytic leukemia, Hematol. Oncol. Clin. North Am, vol.18, pp.915-926, 2004.

E. Montserrat, New prognostic markers in CLL, Hematol. Am. Soc. Hematol. Educ. Program, pp.279-284, 2006.

T. W. Moody, J. Chiles, M. Casibang, E. Moody, D. Chan et al., , 2001.

, SR48692 is a neurotensin receptor antagonist which inhibits the growth of small cell lung cancer cells, Peptides, vol.22, pp.109-115

T. W. Moody, D. C. Chan, S. A. Mantey, P. Moreno, and R. T. Jensen, SR48692 inhibits non-small cell lung cancer proliferation in an EGF receptor-dependent manner, Life Sci, vol.100, pp.25-34, 2014.

T. W. Moody, B. Nuche-berenguer, T. Nakamura, and R. T. Jensen, EGFR Transactivation by Peptide G Protein-Coupled Receptors in Cancer, Curr. Drug Targets, vol.17, pp.520-528, 2016.

R. N. Moore, A. P. Osmand, J. A. Dunn, J. G. Joshi, J. W. Koontz et al., Neurotensin regulation of macrophage colony-stimulating factor-stimulated in vitro myelopoiesis, J. Immunol. Baltim. Md, vol.142, pp.2689-2694, 1950.

F. Morabito, L. Mosca, G. Cutrona, L. Agnelli, G. Tuana et al., Clinical monoclonal B lymphocytosis versus Rai 0 chronic lymphocytic leukemia: A comparison of cellular, cytogenetic, molecular, and clinical features, Clin. Cancer Res. Off. J. Am. Assoc. Cancer Res, vol.19, pp.5890-5900, 2013.

E. J. Moreau, E. Matutes, R. P. A&apos;hern, A. M. Morilla, R. M. Morilla et al., Improvement of the chronic lymphocytic leukemia scoring system with the monoclonal antibody SN8 (CD79b), Am. J. Clin. Pathol, vol.108, pp.378-382, 1997.

A. Morimoto and N. Murakami, [14C]deoxyglucose incorporation into rat brain regions during hypothalamic or peripheral thermal stimulation, Am. J. Physiol, vol.248, pp.84-92, 1985.

N. J. Morris, S. A. Ross, W. S. Lane, S. K. Moestrup, C. M. Petersen et al., Sortilin is the major 110-kDa protein in GLUT4 vesicles from adipocytes, J. Biol. Chem, vol.273, pp.3582-3587, 1998.

V. A. Morrison, Infectious complications of chronic lymphocytic leukaemia: pathogenesis, spectrum of infection, preventive approaches, Best Pract. Res. Clin. Haematol, vol.23, pp.145-153, 2010.

L. M. Morton, R. E. Curtis, M. S. Linet, E. C. Bluhm, M. A. Tucker et al., Second malignancy risks after non-Hodgkin's lymphoma and chronic lymphocytic leukemia: differences by lymphoma subtype, J. Clin. Oncol. Off. J. Am. Soc. Clin. Oncol, vol.28, pp.4935-4944, 2010.

E. Mössner, P. Brünker, S. Moser, U. Püntener, C. Schmidt et al., Increasing the efficacy of CD20 antibody therapy through the engineering of a new type II anti-CD20 antibody with enhanced direct and immune effector cell-mediated B-cell cytotoxicity, Blood, vol.115, pp.4393-4402, 2010.

N. A. Moughal, C. Waters, B. Sambi, S. Pyne, and N. J. Pyne, Nerve growth factor signaling involves interaction between the Trk A receptor and lysophosphatidate receptor 1 systems: nuclear translocation of the lysophosphatidate receptor 1 and Trk A receptors in pheochromocytoma 12 cells, Cell. Signal, vol.16, pp.127-136, 2004.

N. A. Moughal, C. M. Waters, W. J. Valentine, M. Connell, J. C. Richardson et al., Protean agonism of the lysophosphatidic acid receptor-1 with Ki16425 reduces nerve growth factor-induced neurite outgrowth in pheochromocytoma 12 cells, J. Neurochem, vol.98, pp.1920-1929, 2006.

E. Moyse, W. Rostène, M. Vial, K. Leonard, J. Mazella et al., Distribution of neurotensin binding sites in rat brain: a light microscopic radioautographic study using monoiodo, Neuroscience, vol.22, pp.525-536, 1987.

T. Munir, Chronic lymphocytic leukemia, Hematol. Amst. Neth, vol.20, pp.245-246, 2015.

W. C. Mustain, P. G. Rychahou, and B. M. Evers, The role of neurotensin in physiologic and pathologic processes, Curr. Opin. Endocrinol. Diabetes Obes, vol.18, pp.75-82, 2011.

M. Muzio, B. Apollonio, C. Scielzo, M. Frenquelli, I. Vandoni et al., Constitutive activation of distinct BCR-signaling pathways in a subset of CLL patients: a molecular signature of anergy, Blood, vol.112, pp.188-195, 2008.

R. M. Myers, J. W. Shearman, M. O. Kitching, A. Ramos-montoya, D. E. Neal et al., Cancer, chemistry, and the cell: molecules that interact with the neurotensin receptors, ACS Chem. Biol, vol.4, pp.503-525, 2009.

I. Nagel, S. Bug, H. Tönnies, O. Ammerpohl, J. Richter et al., Biallelic inactivation of TRAF3 in a subset of B-cell lymphomas with interstitial del(14)(q24.1q32.33), Leukemia, vol.23, pp.2153-2155, 2009.

M. Najimi, J. M. Maloteaux, and E. Hermans, Cytoskeleton-related trafficking of the EAAC1 glutamate transporter after activation of the G(q/11)-coupled neurotensin receptor NTS1, FEBS Lett, vol.523, pp.224-228, 2002.

C. B. Nemeroff, G. Bissette, A. J. Prange, P. T. Loosen, T. S. Barlow et al., Neurotensin: central nervous system effects of a hypothalamic peptide, Brain Res, vol.128, pp.485-496, 1977.

P. Neri, N. J. Bahlis, C. Paba-prada, and P. Richardson, Treatment of Relapsed/Refractory Multiple Myeloma, Cancer Treat. Res, vol.169, pp.169-194, 2016.

F. Nguyen-khac, , 2010.

, Ann. Biol. Clin. (Paris), vol.68, pp.273-276

M. S. Nielsen, C. Jacobsen, G. Olivecrona, J. Gliemann, and C. M. Petersen, , 1999.

, Sortilin/neurotensin receptor-3 binds and mediates degradation of lipoprotein lipase, J. Biol. Chem, vol.274, pp.8832-8836

M. S. Nielsen, P. Madsen, E. I. Christensen, A. Nykjaer, J. Gliemann et al., The sortilin cytoplasmic tail conveys Golgiendosome transport and binds the VHS domain of the GGA2 sorting protein, EMBO J, vol.20, pp.2180-2190, 2001.

A. S. Nilsson, M. Fainzilber, P. Falck, and C. F. Ibáñez, Neurotrophin-7: a novel member of the neurotrophin family from the zebrafish, FEBS Lett, vol.424, pp.285-290, 1998.

Y. Nishida, N. Adati, R. Ozawa, A. Maeda, Y. Sakaki et al., , 2008.

, Identification and classification of genes regulated by phosphatidylinositol 3-kinase-and TRKB-mediated signalling pathways during neuronal differentiation in two subtypes of the human neuroblastoma cell line SH-SY5Y, BMC Res. Notes, vol.1, p.95

D. Nouel, M. P. Faure, J. A. St-pierre, R. Alonso, R. Quirion et al., , 1997.

, Differential binding profile and internalization process of neurotensin via neuronal and glial receptors, J. Neurosci. Off. J. Soc. Neurosci, vol.17, pp.1795-1803

A. Nykjaer and T. E. Willnow, Sortilin: a receptor to regulate neuronal viability and function, Trends Neurosci, vol.35, pp.261-270, 2012.

A. Nykjaer, R. Lee, K. K. Teng, P. Jansen, P. Madsen et al., Sortilin is essential for proNGFinduced neuronal cell death, Nature, vol.427, pp.843-848, 2004.

A. Nykjaer, T. E. Willnow, and C. M. Petersen, p75NTR-live or let die, Curr. Opin. Neurobiol, vol.15, pp.49-57, 2005.

R. H. Oakley, S. A. Laporte, J. A. Holt, L. S. Barak, C. et al., Molecular determinants underlying the formation of stable intracellular G protein-coupled receptor-betaarrestin complexes after receptor endocytosis*, J. Biol. Chem, vol.276, pp.19452-19460, 2001.

A. Obermeier, H. Halfter, K. H. Wiesmüller, G. Jung, J. Schlessinger et al., Tyrosine 785 is a major determinant of Trk-substrate interaction, EMBO J, vol.12, pp.933-941, 1993.

S. M. O&apos;brien, D. F. Claxton, M. Crump, S. Faderl, T. Kipps et al., Phase I study of obatoclax mesylate (GX15-070), a small molecule pan-Bcl-2 family antagonist, in patients with advanced chronic lymphocytic leukemia, Blood, vol.113, pp.299-305, 2009.

M. Ocejo-garcia, S. I. Ahmed, J. M. Coulson, and P. J. Woll, Use of RT-PCR to detect co-expression of neuropeptides and their receptors in lung cancer, Lung Cancer Amst. Neth, vol.33, pp.1-9, 2001.

K. Ohira, H. Kumanogoh, Y. Sahara, K. J. Homma, H. Hirai et al., A truncated tropomyosin-related kinase B receptor, T1, regulates glial cell morphology via Rho GDP dissociation inhibitor 1, J. Neurosci. Off. J. Soc. Neurosci, vol.25, pp.1343-1353, 2005.

K. Ohira, K. J. Homma, H. Hirai, S. Nakamura, and M. Hayashi, TrkB-T1 regulates the RhoA signaling and actin cytoskeleton in glioma cells, Biochem. Biophys. Res. Commun, vol.342, pp.867-874, 2006.

L. Ohman, L. Franzén, U. Rudolph, L. Birnbaumer, and E. H. Hörnquist, , 2002.

, Regression of Peyer's patches in G alpha i2 deficient mice prior to colitis is associated with reduced expression of Bcl-2 and increased apoptosis, Gut, vol.51, pp.392-397

U. Olszewski, H. , and G. , Neurotensin signaling induces intracellular alkalinization and interleukin-8 expression in human pancreatic cancer cells, Mol. Oncol, vol.3, pp.204-213, 2009.

J. A. Orchard, R. E. Ibbotson, Z. Davis, A. Wiestner, A. Rosenwald et al., ZAP-70 expression and prognosis in chronic lymphocytic leukaemia, Lancet Lond. Engl, vol.363, pp.105-111, 2004.

L. Orci, O. Baetens, C. Rufener, M. Brown, W. Vale et al., Evidence for immunoreactive neurotensin in dog intestinal mucosa, Life Sci, vol.19, pp.559-561, 1976.

D. G. Oscier, A. C. Gardiner, S. J. Mould, S. Glide, Z. A. Davis et al., Multivariate analysis of prognostic factors in CLL: clinical stage, IGVH gene mutational status, and loss or mutation of the p53 gene are independent prognostic factors, Blood, vol.100, pp.1177-1184, 2002.

D. G. Oscier, M. J. Rose-zerilli, N. Winkelmann, D. Gonzalez-de-castro, B. Gomez et al., The clinical significance of NOTCH1 and SF3B1 mutations in the UK LRF CLL4 trial, Blood, vol.121, pp.468-475, 2013.

F. Oury-donat, O. Thurneyssen, N. Gonalons, P. Forgez, D. Gully et al., Characterization of the effect of SR48692 on inositol monophosphate, cyclic GMP and cyclic AMP responses linked to neurotensin receptor activation in neuronal and non-neuronal cells, Br. J. Pharmacol, vol.116, pp.1899-1905, 1995.

Q. Ouyang, X. Gong, H. Xiao, J. Zhou, M. Xu et al., Neurotensin promotes the progression of malignant glioma through NTSR1 and impacts the prognosis of glioma patients, Mol. Cancer, vol.14, p.21, 2015.

Q. Ouyang, G. Chen, J. Zhou, L. Li, Z. Dong et al., Neurotensin signaling stimulates glioblastoma cell proliferation by upregulating c-Myc and inhibiting miR-29b-1 and miR-129-3p, Neuro-Oncol, vol.18, pp.216-226, 2016.

Q. Ouyang, J. Zhou, W. Yang, H. Cui, M. Xu et al., Oncogenic role of neurotensin and neurotensin receptors in various cancers, Clin. Exp. Pharmacol. Physiol, vol.44, pp.841-846, 2017.

S. Paneesha and D. W. Milligan, Stem cell transplantation for chronic lymphocytic leukaemia, Br. J. Haematol, vol.128, pp.145-152, 2005.

Y. P. Pang, B. Cusack, K. Groshan, R. , and E. , Proposed ligand binding site of the transmembrane receptor for neurotensin(8-13), J. Biol. Chem, vol.271, pp.15060-15068, 1996.

H. Parker and J. C. Strefford, The mutational signature of chronic lymphocytic leukemia, Biochem. J, vol.473, pp.3725-3740, 2016.

A. B. Patel, I. Tsilioni, S. E. Leeman, and T. C. Theoharides, Neurotensin stimulates sortilin and mTOR in human microglia inhibitable by methoxyluteolin, a potential therapeutic target for autism, Proc. Natl. Acad. Sci. U. S. A, vol.113, pp.7049-7058, 2016.

S. L. Patterson, T. Abel, T. A. Deuel, K. C. Martin, J. C. Rose et al., , 1996.

, Recombinant BDNF rescues deficits in basal synaptic transmission and hippocampal LTP in BDNF knockout mice, Neuron, vol.16, pp.1137-1145

M. Patz, P. Isaeva, N. Forcob, B. Müller, L. P. Frenzel et al., Comparison of the in vitro effects of the anti-CD20 antibodies rituximab and GA101 on chronic lymphocytic leukaemia cells, Br. J. Haematol, vol.152, pp.295-306, 2011.

R. N. Pearse, S. L. Swendeman, Y. Li, D. Rafii, and B. L. Hempstead, A neurotrophin axis in myeloma: TrkB and BDNF promote tumor-cell survival, Blood, vol.105, pp.4429-4436, 2005.

D. Pelaprat, Interactions between neurotensin receptors and G proteins, Peptides, vol.27, pp.2476-2487, 2006.
URL : https://hal.archives-ouvertes.fr/inserm-00519739

C. Pepper, T. Hoy, and D. P. Bentley, Bcl-2/Bax ratios in chronic lymphocytic leukaemia and their correlation with in vitro apoptosis and clinical resistance, Br. J. Cancer, vol.76, pp.935-938, 1997.

C. Pepper, K. Hooper, A. Thomas, T. Hoy, B. et al., Bcl-2 antisense oligonucleotides enhance the cytotoxicity of chlorambucil in B-cell chronic lymphocytic leukaemia cells, Leuk. Lymphoma, vol.42, pp.491-498, 2001.

C. Pepper, A. Thomas, T. Hoy, B. , and P. , Antisense oligonucleotides complementary to Bax transcripts reduce the susceptibility of B-cell chronic lymphocytic leukaemia cells to apoptosis in a bcl-2 independent manner, Leuk. Lymphoma, vol.43, 2002.

P. Pérez, P. M. Coll, B. L. Hempstead, D. Martín-zanca, and M. V. Chao, NGF binding to the trk tyrosine kinase receptor requires the extracellular immunoglobulin-like domains, Mol. Cell. Neurosci, vol.6, pp.97-105, 1995.

A. Perron, P. Sarret, L. Gendron, T. Stroh, and A. Beaudet, Identification and functional characterization of a 5-transmembrane domain variant isoform of the NTS2 neurotensin receptor in rat central nervous system, J. Biol. Chem, vol.280, pp.10219-10227, 2005.

C. M. Petersen, M. S. Nielsen, A. Nykjaer, L. Jacobsen, N. Tommerup et al., Molecular identification chromatography, J. Biol. Chem, vol.272, pp.3599-3605, 1997.

A. Petlickovski, L. Laurenti, X. Li, S. Marietti, P. Chiusolo et al., Sustained signaling through the B-cell receptor induces Mcl-1 and promotes survival of chronic lymphocytic leukemia B cells, Blood, vol.105, pp.4820-4827, 2005.

D. J. Pettibone, J. F. Hess, P. J. Hey, M. A. Jacobson, M. Leviten et al., The effects of deleting the mouse neurotensin receptor NTR1 on central and peripheral responses to neurotensin, J. Pharmacol. Exp. Ther, vol.300, pp.305-313, 2002.

D. Pfeifer, M. Pantic, I. Skatulla, J. Rawluk, C. Kreutz et al., , 2007.

, Genome-wide analysis of DNA copy number changes and LOH in CLL using high-density SNP arrays, Blood, vol.109, pp.1202-1210

G. Del-poeta, M. Dal-bo, M. I. Del-principe, F. Pozzo, F. M. Rossi et al., Clinical significance of c.7544-7545 delCT NOTCH1 mutation in chronic lymphocytic leukaemia, Br. J. Haematol, vol.160, pp.415-418, 2013.

C. Poinot-chazel, M. Portier, M. Bouaboula, N. Vita, F. Pecceu et al., Activation of mitogen-activated protein kinase couples neurotensin receptor stimulation to induction of the primary response gene Krox-24, Biochem. J, vol.320, pp.145-151, 1996.

E. Popp, A. Schneider, P. Vogel, P. Teschendorf, and B. W. Böttiger, Time course of the hypothermic response to continuously administered neurotensin, Neuropeptides, vol.41, pp.349-354, 2007.

J. M. Dal-porto, S. B. Gauld, K. T. Merrell, D. Mills, A. E. Pugh-bernard et al., B cell antigen receptor signaling 101, Mol. Immunol, vol.41, pp.599-613, 2004.

H. Pospisilova, M. Baens, L. Michaux, M. Stul, P. Van-hummelen et al., Interstitial del(14)(q) involving IGH: a novel recurrent aberration in B-NHL, Leukemia, vol.21, pp.2079-2083, 2007.

A. Postigo, A. M. Calella, B. Fritzsch, M. Knipper, D. Katz et al., Distinct requirements for TrkB and TrkC signaling in target innervation by sensory neurons, Genes Dev, vol.16, pp.633-645, 2002.

J. C. Powell, C. Twomey, R. Jain, and J. V. Mccarthy, Association between Presenilin-1 and TRAF6 modulates regulated intramembrane proteolysis of the p75NTR neurotrophin receptor, J. Neurochem, vol.108, pp.216-230, 2009.

Y. Prakash, M. A. Thompson, L. Meuchel, C. M. Pabelick, C. B. Mantilla et al., Neurotrophins in lung health and disease, Expert Rev. Respir. Med, vol.4, pp.395-411, 2010.

N. Purroy, P. Abrisqueta, J. Carabia, C. Carpio, C. Palacio et al., Co-culture of primary CLL cells with bone marrow mesenchymal cells, CD40 ligand and CpG ODN promotes proliferation of chemoresistant CLL cells phenotypically comparable to those proliferating in vivo, Oncotarget, vol.6, pp.7632-7643, 2015.

N. Put, P. Meeus, B. Chatelain, K. Rack, N. Boeckx et al., Translocation t(14;18) is not associated with inferior outcome in chronic lymphocytic leukemia, Leukemia, vol.23, pp.1201-1204, 2009.

N. J. Pyne, P. , and S. , Receptor tyrosine kinase-G-protein-coupled receptor signalling platforms: out of the shadow?, Trends Pharmacol. Sci, vol.32, pp.443-450, 2011.

X. Qian, A. Riccio, Y. Zhang, and D. D. Ginty, Identification and characterization of novel substrates of Trk receptors in developing neurons, Neuron, vol.21, pp.1017-1029, 1998.

M. S. Qiu and S. H. Green, NGF and EGF rapidly activate p21ras in PC12 cells by distinct, convergent pathways involving tyrosine phosphorylation, Neuron, vol.7, pp.937-946, 1991.

M. P. Quiroga, K. Balakrishnan, A. V. Kurtova, M. Sivina, M. J. Keating et al., B-cell antigen receptor signaling enhances chronic lymphocytic leukemia cell migration and survival: specific targeting with a novel spleen tyrosine kinase inhibitor, vol.114, pp.1029-1037, 2009.

S. Raghoebier, J. Krieken, J. C. Van,-kluin-nelemans, A. Gillis, G. Ommen et al., Oncogene rearrangements in chronic B-cell leukemia, Blood, vol.77, pp.1560-1564, 1991.

K. R. Rai and E. Montserrat, Prognostic factors in chronic lymphocytic leukemia, Semin. Hematol, vol.24, pp.252-256, 1987.

K. R. Rai, A. Sawitsky, E. P. Cronkite, A. D. Chanana, R. N. Levy et al., Clinical staging of chronic lymphocytic leukemia, Blood, vol.46, pp.219-234, 1975.

K. R. Rai, B. L. Peterson, F. R. Appelbaum, J. Kolitz, L. Elias et al., Fludarabine compared with chlorambucil as primary therapy for chronic lymphocytic leukemia, N. Engl. J. Med, vol.343, pp.1750-1757, 2000.

K. R. Rai, C. E. Freter, R. J. Mercier, M. R. Cooper, B. S. Mitchell et al., Alemtuzumab in previously treated chronic lymphocytic leukemia patients who also had received fludarabine, J. Clin. Oncol. Off. J. Am. Soc. Clin. Oncol, vol.20, pp.3891-3897, 2002.
DOI : 10.1200/jco.2002.06.119

R. Raijmakers, K. Kraiczek, A. P. De-jong, S. Mohammed, and A. J. Heck, Exploring the human leukocyte phosphoproteome using a microfluidic reversed-phase-TiO2reversed-phase high-performance liquid chromatography phosphochip coupled to a quadrupole time-of-flight mass spectrometer, Anal. Chem, vol.82, pp.824-832, 2010.

F. Di-raimondo, R. Giustolisi, S. Lerner, E. Cacciola, S. O&apos;brien et al., Retrospective study of the prognostic role of serum thymidine kinase level in CLL patients with active disease treated with fludarabine, Ann. Oncol. Off. J. Eur. Soc. Med. Oncol, vol.12, pp.621-625, 2001.

R. Rajagopal and M. V. Chao, A role for Fyn in Trk receptor transactivation by Gprotein-coupled receptor signaling, Mol. Cell. Neurosci, vol.33, pp.36-46, 2006.
DOI : 10.1016/j.mcn.2006.06.002

R. Rajagopal, Z. Chen, F. S. Lee, and M. V. Chao, Transactivation of Trk neurotrophin receptors by G-protein-coupled receptor ligands occurs on intracellular membranes, J. Neurosci. Off. J. Soc. Neurosci, vol.24, pp.6650-6658, 2004.
DOI : 10.1523/jneurosci.0010-04.2004

URL : http://www.jneurosci.org/content/jneuro/24/30/6650.full.pdf

M. Ramez, M. Bagot, M. Nikolova, L. Boumsell, N. Vita et al., Functional characterization of neurotensin receptors in human cutaneous T cell lymphoma malignant lymphocytes, J. Invest. Dermatol, vol.117, pp.687-693, 2001.

E. Rampazzo, L. Bonaldi, L. Trentin, C. Visco, S. Keppel et al., Telomere length and telomerase levels delineate subgroups of B-cell chronic lymphocytic leukemia with different biological characteristics and clinical outcomes, Haematologica, vol.97, pp.56-63, 2012.
DOI : 10.3324/haematol.2011.049874

URL : http://www.haematologica.org/content/haematol/97/1/56.full.pdf

L. Z. Rassenti, L. Huynh, T. L. Toy, L. Chen, M. J. Keating et al., ZAP-70 compared with immunoglobulin heavychain gene mutation status as a predictor of disease progression in chronic lymphocytic leukemia, N. Engl. J. Med, vol.351, pp.893-901, 2004.

L. Z. Rassenti, S. Jain, M. J. Keating, W. G. Wierda, M. R. Grever et al., Relative value of ZAP-70, CD38, and immunoglobulin mutation status in predicting aggressive disease in chronic lymphocytic leukemia, Blood, vol.112, pp.1923-1930, 2008.

L. F. Reichardt, Neurotrophin-regulated signalling pathways, Philos. Trans. R. Soc. Lond. B. Biol. Sci, vol.361, pp.1545-1564, 2006.
DOI : 10.1098/rstb.2006.1894

URL : http://europepmc.org/articles/pmc1664664?pdf=render

M. Reinecke, Neurotensin. Immunohistochemical localization in central and peripheral nervous system and in endocrine cells and its functional role as neurotransmitter and endocrine hormone, Prog. Histochem. Cytochem, vol.16, pp.1-172, 1985.

M. Reinecke, E. Weihe, R. E. Carraway, S. E. Leeman, and W. G. Forssmann, , 1982.

, Localization of neurotensin immunoreactive nerve fibers in the guinea-pig heart: evidence derived by immunohistochemistry, radioimmunoassay and chromatography, Neuroscience, vol.7, pp.1785-1795

A. Remaury, N. Vita, S. Gendreau, M. Jung, M. Arnone et al., Targeted inactivation of the neurotensin type 1 receptor reveals its role in body temperature control and feeding behavior but not in analgesia, Brain Res, vol.953, pp.63-72, 2002.

M. Reth, Antigen receptor tail clue, Nature, vol.338, pp.383-384, 1989.

F. Richard, S. Barroso, D. Nicolas-ethève, P. Kitabgi, L. et al., , 2001.

, Impaired G protein coupling of the neurotensin receptor 1 by mutations in extracellular loop 3, Eur. J. Pharmacol, vol.433, pp.63-71

F. Richard, S. Barroso, J. Martinez, C. Labbé-jullié, and P. Kitabgi, Agonism, inverse agonism, and neutral antagonism at the constitutively active human neurotensin receptor 2, Mol. Pharmacol, vol.60, pp.1392-1398, 2001.

T. Robak, J. Z. Blo?ski, M. Kasznicki, M. Blasi?ska-morawiec, E. Krykowski et al., Cladribine with prednisone versus chlorambucil with prednisone as first-line therapy in chronic lymphocytic leukemia: report of a prospective, randomized, multicenter trial, Blood, vol.96, pp.2723-2729, 2000.

T. Robak, A. Dmoszynska, P. Solal-céligny, K. Warzocha, J. Loscertales et al., Rituximab plus fludarabine and cyclophosphamide prolongs progression-free survival compared with, p.226, 2010.

, fludarabine and cyclophosphamide alone in previously treated chronic lymphocytic leukemia, J. Clin. Oncol. Off. J. Am. Soc. Clin. Oncol, vol.28, pp.1756-1765

A. W. Roberts, J. F. Seymour, J. R. Brown, W. G. Wierda, T. J. Kipps et al., Substantial susceptibility of chronic lymphocytic leukemia to BCL2 inhibition: results of a phase I study of navitoclax in patients with relapsed or refractory disease, J. Clin. Oncol. Off. J. Am. Soc. Clin. Oncol, vol.30, pp.488-496, 2012.

A. Rodriguez-tébar, G. Dechant, B. , and Y. A. , Binding of brain-derived neurotrophic factor to the nerve growth factor receptor, Neuron, vol.4, pp.487-492, 1990.

A. Rodríguez-tébar, G. Dechant, R. Götz, B. , and Y. A. , Binding of neurotrophin3 to its neuronal receptors and interactions with nerve growth factor and brain-derived neurotrophic factor, EMBO J, vol.11, pp.917-922, 1992.

M. F. De-rooij, A. Kuil, C. R. Geest, E. Eldering, B. Y. Chang et al., The clinically active BTK inhibitor PCI-32765 targets B-cell receptor-and chemokine-controlled adhesion and migration in chronic lymphocytic leukemia, Blood, vol.119, pp.2590-2594, 2012.

R. W. Rooswinkel, B. Van-de-kooij, E. De-vries, M. Paauwe, R. Braster et al., Antiapoptotic potency of Bcl-2 proteins primarily relies on their stability, not binding selectivity, Blood, vol.123, pp.2806-2815, 2014.

E. Rosati, R. Sabatini, G. Rampino, A. Tabilio, M. Di-ianni et al., Constitutively activated Notch signaling is involved in survival and apoptosis resistance of B-CLL cells, Blood, vol.113, pp.856-865, 2009.

C. R. Rose, R. Blum, B. Pichler, A. Lepier, K. W. Kafitz et al., , 2003.

, Truncated TrkB-T1 mediates neurotrophin-evoked calcium signalling in glia cells, Nature, vol.426, pp.74-78

S. Rosell, K. Thor, A. Rökaeus, O. Nyquist, A. Lewenhaupt et al., Plasma concentration of neurotensin-like immunoreactivity (NTLI) and lower esophageal sphincter (LES) pressure in man following infusion of (Gln4)-neurotensin, Acta Physiol. Scand, vol.109, pp.369-375, 1980.

S. Roselli, J. Pundavela, Y. Demont, S. Faulkner, S. Keene et al., Sortilin is associated with breast cancer aggressiveness and contributes to tumor cell adhesion and invasion, Oncotarget, vol.6, pp.10473-10486, 2015.

D. Rossi and G. Gaidano, Richter syndrome: pathogenesis and management, Semin. Oncol, vol.43, pp.311-319, 2016.

D. Rossi, E. Sozzi, A. Puma, L. De-paoli, S. Rasi et al., The prognosis of clinical monoclonal B cell lymphocytosis differs from prognosis of Rai 0 chronic lymphocytic leukaemia and is recapitulated by biological risk factors, Br. J. Haematol, vol.146, pp.64-75, 2009.

D. Rossi, A. Bruscaggin, V. Spina, S. Rasi, H. Khiabanian et al., Mutations of the SF3B1 splicing factor in chronic lymphocytic leukemia: association with progression and fludarabine-refractoriness, Blood, vol.118, pp.6904-6908, 2011.

D. Rossi, V. Spina, F. Forconi, D. Capello, M. Fangazio et al., Molecular history of Richter syndrome: origin from a cell already present at the time of chronic lymphocytic leukemia diagnosis, Int. J. Cancer, vol.130, pp.3006-3010, 2012.

W. H. Rostène, A. , and M. J. , Neurotensin and neuroendocrine regulation, Front. Neuroendocrinol, vol.18, pp.115-173, 1997.

P. P. Roux and P. A. Barker, Neurotrophin signaling through the p75 neurotrophin receptor, Prog. Neurobiol, vol.67, pp.203-233, 2002.

P. P. Roux, A. L. Bhakar, T. E. Kennedy, and P. A. Barker, The p75 neurotrophin receptor activates Akt (protein kinase B) through a phosphatidylinositol 3-kinase-dependent pathway, J. Biol. Chem, vol.276, pp.23097-23104, 2001.

C. Rovère, P. Barbero, and P. Kitabgi, Evidence that PC2 is the endogenous proneurotensin convertase in rMTC 6-23 cells and that PC1-and PC2-transfected PC12 cells differentially process pro-neurotensin, J. Biol. Chem, vol.271, pp.11368-11375, 1996.

C. Rozman and E. Montserrat, Chronic lymphocytic leukemia, N. Engl. J. Med, vol.333, pp.1052-1057, 1995.

F. Ruberti, S. Capsoni, A. Comparini, E. Di-daniel, J. Franzot et al., Phenotypic knockout of nerve growth factor in adult transgenic mice reveals severe deficits in basal forebrain cholinergic neurons, cell death in the spleen, and skeletal muscle dystrophy, J. Neurosci. Off. J. Soc. Neurosci, vol.20, pp.2589-2601, 2000.

G. Russwurm, M. Heinsch, R. Radkowski, R. Erlemann, C. Aul et al., Dasatinib induces complete remission in a patient with primary cerebral involvement of B-cell chronic lymphocytic leukemia failing chemotherapy, Blood, vol.116, pp.2617-2618, 2010.

S. Saada, P. Marget, A. Fauchais, M. Lise, G. Chemin et al., Differential expression of neurotensin and specific receptors, NTSR1 and NTSR2, in normal and malignant human B lymphocytes, J. Immunol. Baltim. Md, vol.189, pp.5293-5303, 1950.
DOI : 10.4049/jimmunol.1102937

URL : https://hal.archives-ouvertes.fr/hal-01819265

K. Saiya-cork, R. Collins, B. Parkin, P. Ouillette, E. Kuizon et al., A pathobiological role of the insulin receptor in chronic lymphocytic leukemia, Clin. Cancer Res. Off. J. Am. Assoc. Cancer Res, vol.17, pp.2679-2692, 2011.

A. H. Salehi, P. P. Roux, C. J. Kubu, C. Zeindler, A. Bhakar et al., NRAGE, a novel MAGE protein, interacts with the p75 neurotrophin receptor and facilitates nerve growth factor-dependent apoptosis, Neuron, vol.27, pp.279-288, 2000.
DOI : 10.1016/s0896-6273(00)00036-2

URL : https://doi.org/10.1016/s0896-6273(00)00036-2

M. Sarfati, S. Chevret, C. Chastang, G. Biron, P. Stryckmans et al., Prognostic importance of serum soluble CD23 level in chronic lymphocytic leukemia, Blood, vol.88, pp.4259-4264, 1996.

P. Sarret, A. Beaudet, J. P. Vincent, and J. Mazella, Regional and cellular distribution of low affinity neurotensin receptor mRNA in adult and developing mouse brain, J. Comp. Neurol, vol.394, pp.344-356, 1998.
DOI : 10.1002/(sici)1096-9861(19980511)394:3<344::aid-cne6>3.3.co;2-8

P. Sarret, A. Perron, T. Stroh, and A. Beaudet, Immunohistochemical distribution of NTS2 neurotensin receptors in the rat central nervous system, J. Comp. Neurol, vol.461, pp.520-538, 2003.

M. Sato, H. Kiyama, S. Yoshida, T. Saika, and M. Tohyama, Postnatal ontogeny of cells expressing prepro-neurotensin/neuromedin N mRNA in the rat forebrain and midbrain: a hybridization histochemical study involving isotope-labeled and enzyme-labeled probes, J. Comp. Neurol, vol.310, pp.300-315, 1991.

M. Sato, S. Shiosaka, and M. Tohyama, Neurotensin and neuromedin N elevate the cytosolic calcium concentration via transiently appearing neurotensin binding sites in cultured rat cortex cells, Brain Res. Dev. Brain Res, vol.58, pp.97-103, 1991.
DOI : 10.1016/0165-3806(91)90241-a

M. Sato, H. Kiyama, and M. Tohyama, Different postnatal development of cells expressing mRNA encoding neurotensin receptor, Neuroscience, vol.48, pp.137-149, 1992.
DOI : 10.1016/0306-4522(92)90344-2

E. Satterwhite, T. Sonoki, T. G. Willis, L. Harder, R. Nowak et al., The BCL11 gene family: involvement of BCL11A in lymphoid malignancies, Blood, vol.98, pp.3413-3420, 2001.

O. Al-sawaf, K. Fischer, B. Eichhorst, and M. Hallek, Targeted Therapy of CLL, Oncol. Res. Treat, vol.39, pp.768-778, 2016.
DOI : 10.1159/000452786

A. Saxena, O. Moshynska, K. Sankaran, S. Viswanathan, and D. P. Sheridan, , 2002.

, Association of a novel single nucleotide polymorphism, G(-248)A, in the 5'-UTR of BAX gene in chronic lymphocytic leukemia with disease progression and treatment resistance, Cancer Lett, vol.187, pp.199-205

A. Saxena, S. Viswanathan, O. Moshynska, P. Tandon, K. Sankaran et al., Mcl-1 and Bcl-2/Bax ratio are associated with treatment response but not with Rai stage in B-cell chronic lymphocytic leukemia, Am. J. Hematol, vol.75, pp.22-33, 2004.

L. Scarfò, A. J. Ferreri, and P. Ghia, Chronic lymphocytic leukaemia, Crit. Rev. Oncol. Hematol, vol.104, pp.169-182, 2016.

V. Schack, D. Casademunt, E. Schweigreiter, R. Meyer, M. Bibel et al., Complete ablation of the neurotrophin receptor p75NTR causes defects both in the nervous and the vascular system, Nat. Neurosci, vol.4, pp.977-978, 2001.

P. Schaeffer, M. C. Laplace, A. Bernat, V. Prabonnaud, D. Gully et al., SR142948A is a potent antagonist of the cardiovascular effects of neurotensin, J. Cardiovasc. Pharmacol, vol.31, pp.545-550, 1998.

C. Schaffner, S. Stilgenbauer, G. A. Rappold, H. Döhner, and P. Lichter, Somatic ATM mutations indicate a pathogenic role of ATM in B-cell chronic lymphocytic leukemia, Blood, vol.94, pp.748-753, 1999.

A. M. Scharenberg, L. A. Humphries, and D. J. Rawlings, Calcium signalling and cellfate choice in B cells, Nat. Rev. Immunol, vol.7, pp.778-789, 2007.
DOI : 10.1038/nri2172

URL : http://europepmc.org/articles/pmc2743935?pdf=render

A. Schenone, J. S. Gill, D. A. Zacharias, and A. J. Windebank, Expression of highand low-affinity neurotrophin receptors on human transformed B lymphocytes, J. Neuroimmunol, vol.64, pp.141-149, 1996.
DOI : 10.1016/0165-5728(95)00162-x

A. Schotte, J. E. Leysen, and P. M. Laduron, Evidence for a displaceable nonspecific [3H]neurotensin binding site in rat brain, Naunyn. Schmiedebergs Arch. Pharmacol, vol.333, pp.400-405, 1986.
DOI : 10.1007/bf00500016

A. Schotte, W. Rostène, and P. M. Laduron, Different subcellular localization of neurotensin-receptor and neurotensin-acceptor sites in the rat brain dopaminergic system, J. Neurochem, vol.50, pp.1026-1031, 1988.

F. Schriever and D. Huhn, New directions in the diagnosis and treatment of chronic lymphocytic leukaemia, Drugs, vol.63, pp.953-969, 2003.

R. Schroers, F. Griesinger, L. Trümper, D. Haase, B. Kulle et al., Combined analysis of ZAP-70 and CD38 expression as a predictor of disease progression in B-cell chronic lymphocytic leukemia, Leukemia, vol.19, pp.750-758, 2005.

P. Schröttner, M. Leick, and M. Burger, The role of chemokines in B cell chronic lymphocytic leukaemia: pathophysiological aspects and clinical impact, Ann. Hematol, vol.89, pp.437-446, 2010.

B. Schuhmann, A. Dietrich, S. Sel, C. Hahn, M. Klingenspor et al., A role for brain-derived neurotrophic factor in B cell development, J. Neuroimmunol, vol.163, pp.15-23, 2005.

M. Schultzberg, T. Hökfelt, G. Nilsson, L. Terenius, J. F. Rehfeld et al., Distribution of peptide-and catecholamine-containing neurons in the gastro-intestinal tract of rat and guinea-pig: immunohistochemical studies with antisera to substance P, vasoactive intestinal polypeptide, enkephalins, somatostatin, gastrin/cholecystokinin, neurotensin and dopamine beta-hydroxylase, Neuroscience, vol.5, pp.689-744, 1980.

J. D. Schwarzmeier, M. Shehata, M. Hilgarth, I. Marschitz, N. Louda et al., The role of soluble CD23 in distinguishing stable and progressive forms of B-chronic lymphocytic leukemia, Leuk. Lymphoma, vol.43, pp.549-554, 2002.

I. Sehgal, S. Powers, B. Huntley, G. Powis, M. Pittelkow et al., , 1994.

, Neurotensin is an autocrine trophic factor stimulated by androgen withdrawal in human prostate cancer, Proc. Natl. Acad. Sci. U. S. A, vol.91, pp.4673-4677

B. H. Selbekk, O. Flaten, and L. E. Hanssen, The in vitro effect of neurotensin on human jejunal mast cells, Scand. J. Gastroenterol, vol.15, pp.457-460, 1980.

L. Sellmann, D. De-beer, M. Bartels, B. Opalka, H. Nückel et al., Telomeres and prognosis in patients with chronic lymphocytic leukaemia, Int. J. Hematol, vol.93, pp.74-82, 2011.

S. Servotte, I. Camby, O. Debeir, C. Deroanne, C. A. Lambert et al., The in vitro influences of neurotensin on the motility characteristics of human U373 glioblastoma cells, Neuropathol. Appl. Neurobiol, vol.32, pp.575-584, 2006.

J. F. Seymour, S. Ma, D. M. Brander, M. Y. Choi, J. Barrientos et al., Venetoclax plus rituximab in relapsed or refractory chronic lymphocytic leukaemia: a phase 1b study, Lancet Oncol, vol.18, pp.230-240, 2017.

M. Sheng and C. Sala, PDZ domains and the organization of supramolecular complexes, Annu. Rev. Neurosci, vol.24, pp.1-29, 2001.

J. Shi and K. V. Kandror, Sortilin is essential and sufficient for the formation of Glut4 storage vesicles in 3T3-L1 adipocytes, Dev. Cell, vol.9, pp.99-108, 2005.

S. Shimizu, J. Tsukada, T. Sugimoto, N. Kikkawa, K. Sasaki et al., Identification of a novel therapeutic target for head and neck squamous cell carcinomas: a role for the neurotensin-neurotensin receptor 1 oncogenic signaling pathway, Int. J. Cancer, vol.123, pp.1816-1823, 2008.

D. Silva, L. Neves, B. M. Moura, L. Cruz, M. T. Carvalho et al., Neurotensin downregulates the pro-inflammatory properties of skin dendritic cells and increases epidermal growth factor expression, Biochim. Biophys. Acta, vol.1813, pp.1863-1871, 2011.

S. D. Skaper, The biology of neurotrophins, signalling pathways, and functional peptide mimetics of neurotrophins and their receptors, CNS Neurol. Disord. Drug Targets, vol.7, pp.46-62, 2008.

S. D. Skaper, The neurotrophin family of neurotrophic factors: an overview, Methods Mol. Biol. Clifton NJ, vol.846, pp.1-12, 2012.

S. Skeldal, A. M. Sykes, S. Glerup, D. Matusica, N. Palstra et al., Mapping of the interaction site between sortilin and the p75 neurotrophin receptor reveals a regulatory role for the sortilin intracellular domain in p75 neurotrophin receptor shedding and apoptosis, J. Biol. Chem, vol.287, pp.43798-43809, 2012.

B. S. Slusher, A. E. Zacco, J. A. Maslanski, T. E. Norris, M. W. Mclane et al., The cloned neurotensin receptor mediates cyclic GMP formation when coexpressed with nitric oxide synthase cDNA, Mol. Pharmacol, vol.46, pp.115-121, 1994.

L. Smolej, Targeted treatment for chronic lymphocytic leukemia: clinical potential of obinutuzumab, Pharmacogenomics Pers. Med, vol.8, pp.1-7, 2015.

L. F. Sniderhan, T. M. Garcia-bates, M. Burgart, S. H. Bernstein, R. P. Phipps et al., Neurotrophin signaling through tropomyosin receptor kinases contributes to survival and proliferation of non-Hodgkin lymphoma, Exp. Hematol, vol.37, pp.1295-1309, 2009.

O. Söder and P. M. Hellström, Neuropeptide regulation of human thymocyte, guinea pig T lymphocyte and rat B lymphocyte mitogenesis, Int. Arch. Allergy Appl. Immunol, vol.84, pp.205-211, 1987.

R. Soderquist, D. J. Bates, A. V. Danilov, and A. Eastman, Gossypol overcomes stroma-mediated resistance to the BCL2 inhibitor ABT-737 in chronic lymphocytic leukemia cells ex vivo, Leukemia, vol.27, pp.2262-2264, 2013.

C. Sole, X. Dolcet, M. F. Segura, H. Gutierrez, M. Diaz-meco et al., The death receptor antagonist FAIM promotes neurite outgrowth by a mechanism that depends on ERK and NF-kapp B signaling, J. Cell Biol, vol.167, pp.479-492, 2004.

S. Somaï, A. Gompel, W. Rostène, and P. Forgez, Neurotensin counteracts apoptosis in breast cancer cells, Biochem. Biophys. Res. Commun, vol.295, pp.482-488, 2002.

S. Somaï, A. Gompel, W. Rostène, and P. Forgez, Neurotensin counteracts apoptosis in breast cancer cells, Biochem. Biophys. Res. Commun, vol.295, pp.482-488, 2002.

F. Souazé, V. Viardot-foucault, N. Roullet, M. Toy-miou-leong, A. Gompel et al., Neurotensin receptor 1 gene activation by the Tcf/beta-catenin pathway is an early event in human colonic adenomas, Carcinogenesis, vol.27, pp.708-716, 2006.

F. Souazé, S. Dupouy, V. Viardot-foucault, E. Bruyneel, S. Attoub et al., Expression of neurotensin and NT1 receptor in human breast cancer: a potential role in tumor progression, Cancer Res, vol.66, pp.6243-6249, 2006.

H. E. Speedy, D. Bernardo, M. C. Sava, G. P. Dyer, M. J. Holroyd et al., A genome-wide association study identifies multiple susceptibility loci for chronic lymphocytic leukemia, Nat. Genet, vol.46, pp.56-60, 2014.

T. Stankovic, P. Weber, G. Stewart, T. Bedenham, J. Murray et al., Inactivation of ataxia telangiectasia mutated gene in B-cell chronic lymphocytic leukaemia, Lancet Lond. Engl, vol.353, pp.26-29, 1999.

R. M. Stephens, D. M. Loeb, T. D. Copeland, T. Pawson, L. A. Greene et al., Trk receptors use redundant signal transduction pathways involving SHC and PLCgamma 1 to mediate NGF responses, Neuron, vol.12, pp.691-705, 1994.

C. Sternini, D. Su, J. Arakawa, R. De-giorgio, D. W. Rickman et al., Cellular localization of Pan-trk immunoreactivity and trkC mRNA in the enteric nervous system, J. Comp. Neurol, vol.368, pp.597-607, 1996.

M. Steurer, G. Pall, S. Richards, G. Schwarzer, J. Bohlius et al., Purine antagonists for chronic lymphocytic leukaemia, Cochrane Database Syst. Rev. CD004270, 2006.

F. K. Stevenson, S. Krysov, A. J. Davies, A. J. Steele, P. et al., B-cell receptor signaling in chronic lymphocytic leukemia, Blood, vol.118, pp.4313-4320, 2011.

F. St-gelais, C. Jomphe, and L. Trudeau, The role of neurotensin in central nervous system pathophysiology: what is the evidence?, J. Psychiatry Neurosci. JPN, vol.31, pp.229-245, 2006.

S. Stilgenbauer and H. Döhner, Campath-1H-induced complete remission of chronic lymphocytic leukemia despite p53 gene mutation and resistance to chemotherapy, N. Engl. J. Med, vol.347, pp.452-453, 2002.

S. Stilgenbauer, L. Bullinger, A. Benner, K. Wildenberger, M. Bentz et al., Incidence and clinical significance of 6q deletions in B cell chronic lymphocytic leukemia, Leukemia, vol.13, pp.1331-1334, 1999.

S. Stilgenbauer, S. Sander, L. Bullinger, A. Benner, E. Leupolt et al., Clonal evolution in chronic lymphocytic leukemia: acquisition of high-risk genomic aberrations associated with unmutated VH, resistance to therapy, and short survival, Haematologica, vol.92, pp.1242-1245, 2007.

S. Stilgenbauer, B. Eichhorst, J. Schetelig, S. Coutre, J. F. Seymour et al., Venetoclax in relapsed or refractory chronic lymphocytic leukaemia with 17p deletion: a multicentre, open-label, phase 2 study, Lancet Oncol, vol.17, pp.768-778, 2016.
DOI : 10.1016/s1470-2045(16)30019-5

P. Stoilov, E. Castren, and S. Stamm, Analysis of the human TrkB gene genomic organization reveals novel TrkB isoforms, unusual gene length, and splicing mechanism, Biochem. Biophys. Res. Commun, vol.290, pp.1054-1065, 2002.

P. Strati, C. , and F. , A matter of debate in chronic lymphocytic leukemia: is the occurrence of autoimmune disorders an indicator of chronic lymphocytic leukemia therapy?, Curr. Opin. Oncol, vol.23, pp.455-460, 2011.

M. Sundaresan, Z. X. Yu, V. J. Ferrans, K. Irani, and T. Finkel, Requirement for generation of H2O2 for platelet-derived growth factor signal transduction, Science, vol.270, pp.296-299, 1995.
DOI : 10.1126/science.270.5234.296

URL : https://zenodo.org/record/1231056/files/article.pdf

N. Suwaki, E. Vanhecke, K. M. Atkins, M. Graf, K. Swabey et al., A HIF-regulated VHL-PTP1B-Src signaling axis identifies a therapeutic target in renal cell carcinoma, Sci. Transl. Med, vol.3, pp.85-132, 2011.

S. L. Swift, J. E. Burns, and N. J. Maitland, Altered expression of neurotensin receptors is associated with the differentiation state of prostate cancer, Cancer Res, vol.70, pp.347-356, 2010.

A. Tacconelli, A. R. Farina, L. Cappabianca, G. Desantis, A. Tessitore et al., TrkA alternative splicing: a regulated tumor-promoting switch in human neuroblastoma, Cancer Cell, vol.6, pp.347-360, 2004.
DOI : 10.2217/14796694.1.5.689

A. Tacconelli, A. R. Farina, L. Cappabianca, G. Cea, S. Panella et al., TrkAIII expression in the thymus, J. Neuroimmunol, vol.183, pp.151-161, 2007.
DOI : 10.1016/j.jneuroim.2006.12.005

H. Takatsu, Y. Katoh, Y. Shiba, and K. Nakayama, Golgi-localizing, gamma-adaptin ear homology domain, ADP-ribosylation factor-binding (GGA) proteins interact with acidic dileucine sequences within the cytoplasmic domains of sorting receptors through their Vps27p/Hrs/STAM (VHS) domains, J. Biol. Chem, vol.276, pp.28541-28545, 2001.

S. Y. Tam, M. Tsai, M. Yamaguchi, K. Yano, J. H. Butterfield et al., Expression of functional TrkA receptor tyrosine kinase in the HMC-1 human mast cell line and in human mast cells, Blood, vol.90, pp.1807-1820, 1997.

K. Tanaka, M. Masu, and S. Nakanishi, Structure and functional expression of the cloned rat neurotensin receptor, Neuron, vol.4, pp.847-854, 1990.
DOI : 10.1016/0896-6273(90)90137-5

K. H. Tang, S. Ma, T. K. Lee, Y. P. Chan, P. S. Kwan et al., CD133(+) liver tumor-initiating cells promote tumor angiogenesis, growth, and self-renewal through neurotensin/interleukin-8/CXCL1 signaling, Hepatol. Baltim. Md, vol.55, pp.807-820, 2012.
DOI : 10.1002/hep.24739

URL : http://onlinelibrary.wiley.com/doi/10.1002/hep.24739/pdf

M. Taniuchi, E. M. Johnson, P. J. Roach, L. , and J. C. , Phosphorylation of nerve growth factor receptor proteins in sympathetic neurons and PC12 cells. In vitro phosphorylation by the cAMP-independent protein kinase FA/GSK-3, J. Biol. Chem, vol.261, pp.13342-13349, 1986.

D. Tavares, K. Tully, and P. R. Dobner, Sequences required for induction of neurotensin receptor gene expression during neuronal differentiation of N1E-115 neuroblastoma cells, J. Biol. Chem, vol.274, pp.30066-30079, 1999.

H. K. Teng, K. K. Teng, R. Lee, S. Wright, S. Tevar et al., ProBDNF induces neuronal apoptosis via activation of a receptor complex of p75NTR and sortilin, J. Neurosci. Off. J. Soc. Neurosci, vol.25, pp.5455-5463, 2005.

C. J. Thiele, Z. Li, and A. E. Mckee, On Trk-the TrkB signal transduction pathway is an increasingly important target in cancer biology, Clin. Cancer Res. Off. J. Am. Assoc. Cancer Res, vol.15, pp.5962-5967, 2009.

J. B. Thomas, A. M. Giddings, R. W. Wiethe, S. Olepu, K. R. Warner et al., methoxyphenyl)-1H-pyrazol-3-yl]carbonyl}amino)cyclohexane carboxylic acid as a selective nonpeptide neurotensin receptor type 2 compound, J. Med. Chem, vol.57, issue.5, pp.5318-5332, 2014.
DOI : 10.1021/jm5003843

URL : https://doi.org/10.1021/jm5003843

S. M. Thomas, M. Demarco, G. D&apos;arcangelo, S. Halegoua, and J. S. Brugge, Ras is essential for nerve growth factor-and phorbol ester-induced tyrosine phosphorylation of MAP kinases, Cell, vol.68, pp.1031-1040, 1992.

W. G. Thomas, Y. Brandenburger, D. J. Autelitano, T. Pham, H. Qian et al., Adenoviral-directed expression of the type 1A angiotensin receptor promotes cardiomyocyte hypertrophy via transactivation of the epidermal growth factor receptor, Circ. Res, vol.90, pp.135-142, 2002.

M. Ticchioni, M. Essafi, P. Y. Jeandel, F. Davi, J. P. Cassuto et al., Homeostatic chemokines increase survival of B-chronic lymphocytic leukemia cells through inactivation of transcription factor FOXO3a, Oncogene, vol.26, pp.7081-7091, 2007.

G. Tobin, U. Thunberg, A. Johnson, I. Eriksson, O. Söderberg et al., Chronic lymphocytic leukemias utilizing the VH3-21 gene display highly restricted Vlambda2-14 gene use and homologous CDR3s: implicating recognition of a common antigen epitope, Blood, vol.101, pp.4952-4957, 2003.

R. E. Toman, S. G. Payne, K. R. Watterson, M. Maceyka, N. H. Lee et al., Differential transactivation of sphingosine-1-phosphate receptors modulates NGF-induced neurite extension, J. Cell Biol, vol.166, pp.381-392, 2004.

M. L. Tomasi, M. Ryoo, K. Ramani, I. Tomasi, P. Giordano et al., Methionine adenosyltransferase ?2 sumoylation positively regulate Bcl-2 expression in human colon and liver cancer cells, Oncotarget, vol.6, pp.37706-37723, 2015.

S. A. Tooze, Cell biology. GGAs tie up the loose ends, Science, vol.292, pp.1663-1665, 2001.

M. Torcia, L. Bracci-laudiero, M. Lucibello, L. Nencioni, D. Labardi et al., Nerve growth factor is an autocrine survival factor for memory B lymphocytes, Cell, vol.85, pp.345-356, 1996.

M. Trbusek, J. Malcikova, J. Smardova, V. Kuhrova, D. Mentzlova et al., Inactivation of p53 and deletion of ATM in B-CLL patients in relation to IgVH mutation status and previous treatment, Leukemia, vol.20, pp.1159-1161, 2006.

J. Troppmair, J. T. Bruder, H. App, H. Cai, L. Liptak et al., Ras controls coupling of growth factor receptors and protein kinase C in the membrane to Raf-1 and B-Raf protein serine kinases in the cytosol, Oncogene, vol.7, pp.1867-1873, 1992.

F. Truzzi, A. Marconi, R. Lotti, K. Dallaglio, L. E. French et al., Neurotrophins and their receptors stimulate melanoma cell proliferation and migration, J. Invest. Dermatol, vol.128, pp.2031-2040, 2008.

A. Tsimberidou and M. J. Keating, Richter syndrome: biology, incidence, and therapeutic strategies, Cancer, vol.103, pp.216-228, 2005.

A. M. Tsimberidou, S. M. O&apos;brien, J. E. Cortes, S. Faderl, M. Andreeff et al., Phase II study of fludarabine, cytarabine (Ara-C), cyclophosphamide, cisplatin and GM-CSF (FACPGM) in patients with Richter's syndrome or refractory lymphoproliferative disorders, Leuk. Lymphoma, vol.43, pp.767-772, 2002.

Y. Tsujimoto, L. R. Finger, J. Yunis, P. C. Nowell, C. et al., Cloning of the chromosome breakpoint of neoplastic B cells with the t(14;18) chromosome translocation, Science, vol.226, pp.1097-1099, 1984.

J. T. Turner, M. R. James-kracke, and J. M. Camden, Regulation of the neurotensin receptor and intracellular calcium mobilization in HT29 cells, J. Pharmacol. Exp. Ther, vol.253, pp.1049-1056, 1990.

B. M. Tyler, K. Jansen, D. J. Mccormick, C. L. Douglas, M. Boules et al., Peptide nucleic acids targeted to the neurotensin receptor and administered i.p. cross the blood-brain barrier and specifically reduce gene expression, Proc. Natl. Acad. Sci. U. S. A, vol.96, pp.7053-7058, 1999.

B. M. Tyler-mcmahon, M. Boules, R. , and E. , Neurotensin: peptide for the next millennium, Regul. Pept, vol.93, pp.125-136, 2000.

G. R. Uhl, M. J. Kuhar, and S. H. Snyder, Neurotensin: immunohistochemical localization in rat central nervous system, Proc. Natl. Acad. Sci. U. S. A, vol.74, pp.4059-4063, 1977.

C. K. Underwood, K. Reid, L. M. May, P. F. Bartlett, and E. J. Coulson, Palmitoylation of the C-terminal fragment of p75(NTR) regulates death signaling and is required for subsequent cleavage by gamma-secretase, Mol. Cell. Neurosci, vol.37, pp.346-358, 2008.

C. B. Vaegter, P. Jansen, A. W. Fjorback, S. Glerup, S. Skeldal et al., Sortilin associates with Trk receptors to enhance anterograde transport and neurotrophin signaling, Nat. Neurosci, vol.14, pp.54-61, 2011.

M. A. Vanisberg, J. M. Maloteaux, J. N. Octave, and P. M. Laduron, Rapid agonistinduced decrease of neurotensin receptors from the cell surface in rat cultured neurons, Biochem. Pharmacol, vol.42, pp.2265-2274, 1991.

Y. Vanneste, A. N. Thome, E. Vandersmissen, C. Charlet, D. Franchimont et al., Identification of neurotensin-related peptides in human thymic epithelial cell membranes and relationship with major histocompatibility complex class I molecules, J. Neuroimmunol, vol.76, pp.161-166, 1997.

M. Vasiadi, A. P. Mondolfi, K. Alysandratos, A. Therianou, A. Katsarou-katsari et al., Neurotensin serum levels and skin gene expression are increased in atopic dermatitis, Br. J. Dermatol, vol.169, pp.695-699, 2013.
DOI : 10.1111/bjd.12413

J. A. Vega, O. García-suárez, J. Hannestad, M. Pérez-pérez, G. et al., Neurotrophins and the immune system, J. Anat, vol.203, pp.1-19, 2003.

L. Véronèse, O. Tournilhac, M. Callanan, N. Prie, F. Kwiatkowski et al., Telomeres and chromosomal instability in chronic lymphocytic leukemia, Leukemia, vol.27, pp.490-493, 2013.

M. Vias, G. Burtt, Z. Culig, A. Veerakumarasivam, D. E. Neal et al., A role for neurotensin in bicalutamide resistant prostate cancer cells, The Prostate, vol.67, pp.190-202, 2007.

M. Vilar, I. Charalampopoulos, R. S. Kenchappa, A. Simi, E. Karaca et al., Activation of the p75 neurotrophin receptor through conformational rearrangement of disulphide-linked receptor dimers, Neuron, vol.62, pp.72-83, 2009.

B. Vincent, J. P. Vincent, C. , and F. , Neurotensin and neuromedin N undergo distinct catabolic processes in murine astrocytes and primary cultured neurons, Eur. J. Biochem, vol.221, pp.297-306, 1994.

J. P. Vincent, J. Mazella, and P. Kitabgi, Neurotensin and neurotensin receptors, Trends Pharmacol. Sci, vol.20, pp.302-309, 1999.
URL : https://hal.archives-ouvertes.fr/hal-00171827

A. Visentin, C. Gurrieri, S. Imbergamo, F. Lessi, S. A. Di-maggio et al., Epidemiology and risk factors of invasive fungal infections in a large cohort of patients with chronic lymphocytic leukemia, Hematol. Oncol, 2016.

N. Vita, P. Laurent, S. Lefort, P. Chalon, X. Dumont et al., Cloning and expression of a complementary DNA encoding a high affinity human neurotensin receptor, FEBS Lett, vol.317, pp.139-142, 1993.

N. Vita, F. Oury-donat, P. Chalon, M. Guillemot, M. Kaghad et al., Neurotensin is an antagonist of the human neurotensin NT2 receptor expressed in Chinese hamster ovary cells, Eur. J. Pharmacol, vol.360, pp.265-272, 1998.

K. S. Vogel, M. El-afandi, and L. F. Parada, Neurofibromin negatively regulates neurotrophin signaling through p21ras in embryonic sensory neurons, Mol. Cell. Neurosci, vol.15, pp.398-407, 2000.
DOI : 10.1006/mcne.2000.0836

R. Vrhovac, A. Delmer, R. Tang, J. P. Marie, R. Zittoun et al., Prognostic significance of the cell cycle inhibitor p27Kip1 in chronic B-cell lymphocytic leukemia, Blood, vol.91, pp.4694-4700, 1998.

N. Walker, I. Lepee-lorgeoux, J. Fournier, C. Betancur, W. Rostene et al., Tissue distribution and cellular localization of the levocabastine-sensitive neurotensin receptor mRNA in adult rat brain, Brain Res. Mol. Brain Res, vol.57, pp.193-200, 1998.

H. S. Walter, S. A. Rule, M. J. Dyer, L. Karlin, C. Jones et al., A phase 1 clinical trial of the selective BTK, p.236, 2016.
URL : https://hal.archives-ouvertes.fr/hal-01796198

, GS-4059 in relapsed and refractory mature B-cell malignancies, Blood, vol.127, pp.411-419

H. L. Wang and T. Wu, G alpha q/11 mediates neurotensin excitation of substantia nigra dopaminergic neurons, Brain Res. Mol. Brain Res, vol.36, pp.29-36, 1996.
DOI : 10.1016/0169-328x(95)00235-k

J. Wang, N. Li, H. Li, L. Cui, W. et al., Pancreatic cancer bears overexpression of neurotensin and neurotensin receptor subtype-1 and SR 48692 counteracts neurotensin induced cell proliferation in human pancreatic ductal carcinoma cell line PANC-1, Neuropeptides, vol.45, pp.151-156, 2011.

L. Wang, H. Friess, Z. Zhu, H. Graber, A. Zimmermann et al., Neurotensin receptor-1 mRNA analysis in normal pancreas and pancreatic disease, Clin. Cancer Res. Off. J. Am. Assoc. Cancer Res, vol.6, pp.566-571, 2000.

W. Wang, L. Liu, H. Sun, Y. Fu, H. Xu et al., Tanshinone IIA inhibits metastasis after palliative resection of hepatocellular carcinoma and prolongs survival in part via vascular normalization, J. Hematol. Oncol.J Hematol Oncol, vol.5, p.69, 2012.

F. L. Watson, M. A. Porcionatto, A. Bhattacharyya, C. D. Stiles, and R. A. Segal, , 1999.

, TrkA glycosylation regulates receptor localization and activity, J. Neurobiol, vol.39, pp.323-336

N. S. Weiss, Geographical variation in the incidence of the leukemias and lymphomas, Natl. Cancer Inst. Monogr, pp.139-142, 1979.

A. Weiss and J. Schlessinger, Switching signals on or off by receptor dimerization, Cell, vol.94, pp.277-280, 1998.
DOI : 10.1016/s0092-8674(00)81469-5

URL : https://doi.org/10.1016/s0092-8674(00)81469-5

R. Wetzker and F. Böhmer, Transactivation joins multiple tracks to the ERK/MAPK cascade, Nat. Rev. Mol. Cell Biol, vol.4, pp.651-657, 2003.
DOI : 10.1038/nrm1173

P. H. Wiernik, M. Ashwin, X. P. Hu, E. Paietta, and K. Brown, Anticipation in familial chronic lymphocytic leukaemia, Br. J. Haematol, vol.113, pp.407-414, 2001.
DOI : 10.1046/j.1365-2141.2001.02773.x

URL : https://onlinelibrary.wiley.com/doi/pdf/10.1046/j.1365-2141.2001.02773.x

A. Wiestner, Emerging role of kinase-targeted strategies in chronic lymphocytic leukemia, Hematol. Am. Soc. Hematol. Educ. Program, pp.88-96, 2012.

S. Willimott and S. D. Wagner, Post-transcriptional and post-translational regulation of Bcl2, Biochem. Soc. Trans, vol.38, pp.1571-1575, 2010.

C. M. Wilson, T. Naves, S. Saada, S. Pinet, F. Vincent et al., The implications of sortilin/vps10p domain receptors in neurological and human diseases, CNS Neurol. Disord. Drug Targets, vol.13, pp.1354-1365, 2014.
URL : https://hal.archives-ouvertes.fr/hal-01827711

C. M. Wilson, T. Naves, F. Vincent, B. Melloni, F. Bonnaud et al., Sortilin mediates the release and transfer of exosomes in concert with two tyrosine kinase receptors, J. Cell Sci, vol.127, pp.3983-3997, 2014.
URL : https://hal.archives-ouvertes.fr/hal-01059696

I. Wlodarska, C. Matthews, E. Veyt, H. Pospisilova, M. A. Catherwood et al., Telomeric IGH losses detectable by fluorescence in situ hybridization in chronic lymphocytic leukemia reflect somatic VH recombination events, J. Mol. Diagn. JMD, vol.9, pp.47-54, 2007.

S. T. Wong, J. R. Henley, K. C. Kanning, K. Huang, M. Bothwell et al., A p75(NTR) and Nogo receptor complex mediates repulsive signaling by myelin-associated glycoprotein, Nat. Neurosci, vol.5, pp.1302-1308, 2002.
DOI : 10.1038/nn975

M. W. Wooten, M. L. Seibenhener, V. Mamidipudi, M. T. Diaz-meco, P. A. Barker et al., The atypical protein kinase C-interacting protein p62 is a scaffold for NFkappaB activation by nerve growth factor, J. Biol. Chem, vol.276, pp.7709-7712, 2001.
DOI : 10.1074/jbc.c000869200

URL : http://www.jbc.org/content/276/11/7709.full.pdf

C. Wu, C. F. Lai, and W. C. Mobley, Nerve growth factor activates persistent Rap1 signaling in endosomes, J. Neurosci. Off. J. Soc. Neurosci, vol.21, pp.5406-5416, 2001.
DOI : 10.1523/jneurosci.21-15-05406.2001

URL : http://www.jneurosci.org/content/21/15/5406.full.pdf

Z. Wu, A. Galmiche, J. Liu, N. Stadler, D. Wendum et al., Neurotensin regulation induces overexpression and activation of EGFR in HCC and restores response to erlotinib and sorafenib, Cancer Lett, vol.388, pp.73-84, 2017.

D. Xia, W. Li, L. Zhang, H. Qian, S. Yao et al., RNA interference-mediated knockdown of brain-derived neurotrophic factor (BDNF) promotes cell cycle arrest and apoptosis in B-cell lymphoma cells, Neoplasma, vol.61, pp.523-532, 2014.

J. Xing, D. D. Ginty, and M. E. Greenberg, Coupling of the RAS-MAPK pathway to gene activation by RSK2, a growth factor-regulated CREB kinase, Science, vol.273, pp.959-963, 1996.

N. Yaktapour, R. Übelhart, J. Schüler, K. Aumann, C. Dierks et al., Insulin-like growth factor-1 receptor (IGF1R) as a novel target in chronic lymphocytic leukemia, Blood, vol.122, pp.1621-1633, 2013.
DOI : 10.1182/blood-2013-02-484386

URL : http://www.bloodjournal.org/content/122/9/1621.full.pdf

M. Yamada, M. Yamada, M. A. Watson, R. , and E. , Neurotensin stimulates cyclic AMP formation in CHO-rNTR-10 cells expressing the cloned rat neurotensin receptor, Eur. J. Pharmacol, vol.244, pp.99-101, 1993.

M. Yamada, M. Yamada, M. A. Watson, R. , and E. , Deletion mutation in the putative third intracellular loop of the rat neurotensin receptor abolishes polyphosphoinositide hydrolysis but not cyclic AMP formation in CHO-K1 cells, Mol. Pharmacol, vol.46, pp.470-476, 1994.

M. Yamada, M. Yamada, A. Lombet, P. Forgez, R. et al., Distinct functional characteristics of levocabastine sensitive rat neurotensin NT2 receptor expressed in Chinese hamster ovary cells, Life Sci, vol.62, pp.375-380, 1998.

T. Yamashita, K. L. Tucker, B. , and Y. A. , Neurotrophin binding to the p75 receptor modulates Rho activity and axonal outgrowth, Neuron, vol.24, pp.585-593, 1999.

H. Yan and M. V. Chao, Disruption of cysteine-rich repeats of the p75 nerve growth factor receptor leads to loss of ligand binding, J. Biol. Chem, vol.266, pp.12099-12104, 1991.

H. Yano and M. V. Chao, Neurotrophin receptor structure and interactions, Pharm. Acta Helv, vol.74, pp.253-260, 2000.

H. Yano, R. Torkin, L. A. Martin, M. V. Chao, and K. K. Teng, Proneurotrophin-3 is a neuronal apoptotic ligand: evidence for retrograde-directed cell killing, J. Neurosci. Off. J. Soc. Neurosci, vol.29, pp.14790-14802, 2009.

X. Ye, P. Mehlen, S. Rabizadeh, T. Vanarsdale, H. Zhang et al., TRAF family proteins interact with the common neurotrophin receptor and modulate apoptosis induction, J. Biol. Chem, vol.274, pp.30202-30208, 1999.

Y. Ye, X. Long, L. Zhang, J. Chen, P. Liu et al., NTS/NTR1 co-expression enhances epithelial-to-mesenchymal transition and promotes tumor metastasis by activating the Wnt/?-catenin signaling pathway in hepatocellular carcinoma, Oncotarget, vol.7, pp.70303-70322, 2016.

E. C. Yeiser, N. J. Rutkoski, A. Naito, J. Inoue, and B. D. Carter, Neurotrophin signaling through the p75 receptor is deficient in traf6-/-mice, J. Neurosci. Off. J. Soc. Neurosci, vol.24, pp.10521-10529, 2004.

G. Yoffe, P. N. Howard-peebles, R. G. Smith, P. W. Tucker, and G. R. Buchanan, , 1990.

, Childhood chronic lymphocytic leukemia with (2;14) translocation, J. Pediatr, vol.116, pp.114-117

R. D. York, H. Yao, T. Dillon, C. L. Ellig, S. P. Eckert et al., Rap1 mediates sustained MAP kinase activation induced by nerve growth factor, Nature, vol.392, pp.622-626, 1998.

R. D. York, D. C. Molliver, S. S. Grewal, P. E. Stenberg, E. W. Mccleskey et al., Role of phosphoinositide 3-kinase and endocytosis in nerve growth factor-induced extracellular signal-regulated kinase activation via Ras and Rap1, Mol. Cell. Biol, vol.20, pp.8069-8083, 2000.

M. Younes, Z. Wu, S. Dupouy, A. M. Lupo, N. Mourra et al., Neurotensin (NTS) and its receptor (NTSR1) causes EGFR, HER2 and HER3 over-expression and their autocrine/paracrine activation in lung tumors, confirming responsiveness to erlotinib, Oncotarget, vol.5, pp.8252-8269, 2014.

J. H. Young, Epidemiology and management of infectious complications of contemporary management of chronic leukemias, Infect. Disord. Drug Targets, vol.11, pp.3-10, 2011.

J. Yu, X. Ren, Y. Chen, P. Liu, X. Wei et al., Dysfunctional activation of neurotensin/IL-8 pathway in hepatocellular carcinoma is associated with increased inflammatory response in microenvironment, more epithelial mesenchymal transition in cancer and worse prognosis in patients, PloS One, vol.8, p.56069, 2013.

M. R. Yuille, E. Matutes, A. Marossy, B. Hilditch, D. Catovsky et al., , 2000.

, Familial chronic lymphocytic leukaemia: a survey and review of published studies, Br. J. Haematol, vol.109, pp.794-799

C. S. Zent, K. , and N. E. , Autoimmune complications in chronic lymphocytic leukaemia (CLL), Best Pract. Res. Clin. Haematol, vol.23, pp.47-59, 2010.

T. Zenz, A. Kröber, K. Scherer, S. Häbe, A. Bühler et al., Monoallelic TP53 inactivation is associated with poor prognosis in chronic lymphocytic leukemia: results from a detailed genetic characterization with long-term follow-up, Blood, vol.112, pp.3322-3329, 2008.

T. Zenz, J. Mohr, J. Edelmann, A. Sarno, P. Hoth et al., Treatment resistance in chronic lymphocytic leukemia: the role of the p53 pathway, Leuk. Lymphoma, vol.50, pp.510-513, 2009.

X. Zhang, Z. Q. Xu, L. Bao, A. Dagerlind, and T. Hökfelt, Complementary distribution of receptors for neurotensin and NPY in small neurons in rat lumbar DRGs and regulation of the receptors and peptides after peripheral axotomy, J. Neurosci. Off. J. Soc. Neurosci, vol.15, pp.2733-2747, 1995.

Y. Zhang, P. Matthiesen, S. Harder, R. Siebert, G. Castoldi et al., A 3-cM commonly deleted region in 6q21 in leukemias and lymphomas delineated by fluorescence in situ hybridization, Genes. Chromosomes Cancer, vol.27, pp.52-58, 2000.

Y. Zhang, S. Zhu, L. Yi, Y. Liu, C. et al., Neurotensin receptor1 antagonist SR48692 reduces proliferation by inducing apoptosis and cell cycle arrest in melanoma cells, Mol. Cell. Biochem, vol.389, pp.1-8, 2014.

D. Zhao, S. Kuhnt-moore, H. Zeng, J. S. Wu, M. P. Moyer et al., Neurotensin stimulates IL-8 expression in human colonic epithelial cells through Rho GTPase-mediated NF-kappa B pathways, Am. J. Physiol. Cell Physiol, vol.284, pp.1397-1404, 2003.

D. Zhao, Y. Zhan, H. Zeng, H. W. Koon, M. P. Moyer et al., Neurotensin stimulates expression of early growth response gene-1 and EGF receptor through MAP kinase activation in human colonic epithelial cells, Int. J. Cancer, vol.120, pp.1652-1656, 2007.

D. Zhao, K. Bakirtzi, Y. Zhan, H. Zeng, H. W. Koon et al., Insulinlike growth factor-1 receptor transactivation modulates the inflammatory and proliferative responses of neurotensin in human colonic epithelial cells, J. Biol. Chem, vol.286, pp.6092-6099, 2011.

W. Zheng, S. Kar, Q. , and R. , FKHRL1 and its homologs are new targets of nerve growth factor Trk receptor signaling, J. Neurochem, vol.80, pp.1049-1061, 2002.

J. Zhou, L. Yi, Q. Ouyang, L. Xu, H. Cui et al., Neurotensin signaling regulates stem-like traits of glioblastoma stem cells through activation of IL-8/CXCR1/STAT3 pathway, Cell. Signal, vol.26, pp.2896-2902, 2014.

N. Zsürger, J. Chabry, A. Coquerel, and J. P. Vincent, Ontogenesis and binding properties of high-affinity neurotensin receptors in human brain, Brain Res, vol.586, pp.303-310, 1992.

N. Zsürger, J. Mazella, and J. P. Vincent, Solubilization and purification of a high affinity neurotensin receptor from newborn human brain, Brain Res, vol.639, pp.245-252, 1994.

A. A. Zupan, P. A. Osborne, C. E. Smith, N. R. Siegel, R. M. Leimgruber et al., Identification, purification, and characterization of truncated forms of the human nerve growth factor receptor, J. Biol. Chem, vol.264, pp.11714-11720, 1989.

S. Zupo, R. Massara, M. Dono, E. Rossi, F. Malavasi et al., Apoptosis or plasma cell differentiation of CD38-positive B-chronic lymphocytic leukemia cells induced by cross-linking of surface IgM or IgD, Blood, vol.95, pp.1199-1206, 2000.