Fatty acid composition in matrix vesicles and in microvilli from femurs of chicken embryos revealed selective recruitment of fatty acids, Biochem Biophys Res Commun, vol.446, pp.1161-1164, 2014. ,
URL : https://hal.archives-ouvertes.fr/hal-00991044
Focal arterial inflammation precedes subsequent calcification in the same location: a longitudinal FDG-PET/CT study, Circ Cardiovasc Imaging, vol.6, pp.747-754, 2013. ,
Cholesterol crystals cause mechanical damage to biological membranes: a proposed mechanism of plaque rupture and erosion leading to arterial thrombosis, Clin Cardiol, vol.28, pp.413-420, 2005. ,
Effect of cholesterol crystals on plaques and intima in arteries of patients with acute coronary and cerebrovascular syndromes, Am J Cardiol, vol.103, pp.959-968, 2009. ,
, , 2007.
, Pyrophosphate Inhibits Mineralization of Osteoblast Cultures by Binding to Mineral, Upregulating Osteopontin, and Inhibiting Alkaline Phosphatase Activity, J Biol Chem, vol.282, pp.15872-15883
Expression of cartilage-specific markers in calcified and non-calcified atherosclerotic lesions, Atherosclerosis, vol.196, pp.37-41, 2008. ,
, Osteogenesis Associates With Inflammation in Early-Stage Atherosclerosis Evaluated by Molecular Imaging In Vivo, vol.116, pp.2841-2850, 2007.
Evidence for apoptosis in advanced human atheroma. Colocalization with interleukin-1 beta-converting enzyme, Am J Pathol, vol.147, pp.251-266, 1995. ,
Role of Cellular Cholesterol Metabolism in Vascular Cell Calcification, J Biol Chem, vol.286, pp.33701-33706, 2011. ,
Kinetic analysis of mineral formation during in vitro modeling of matrix vesicle mineralization: Effect of annexin A5, phosphatidylserine, and type II collagen, Anal Biochem, vol.367, pp.159-166, 2007. ,
Mineralization of Annexin-5-containing Lipid-Calcium-Phosphate Complexes: modulation by varying lipid composition and incubation with cartilage collagens, J Biol Chem, vol.283, pp.9737-9748, 2008. ,
Importance of phosphorylation for osteopontin regulation of biomineralization, Calcif Tissue Int, vol.77, pp.45-54, 2005. ,
Annexins: From Structure to Function, Physiol Rev, vol.82, pp.331-371, 2002. ,
Apoprotein E as a lipid transport and signaling protein in the blood, liver, and artery wall, J Lipid Res, vol.50, pp.156-161, 2009. ,
The role of annexin 2 in osteoblastic mineralization, J Cell Sci, vol.117, pp.441-449, 2004. ,
Atherosclerosis: the road ahead, Cell, vol.104, pp.503-516, 2001. ,
Sortilin mediates vascular calcification via its recruitment into extracellular vesicles, J Clin Invest, vol.126, pp.1323-1336, 2016. ,
The control of chondrogenesis, J Cell Biochem, vol.97, pp.33-44, 2006. ,
Role of matrix vesicles in biomineralization, Biochim Biophys Acta, vol.1790, pp.1592-1598, 2009. ,
Primary culture and phenotyping of murine chondrocytes, Nat Protoc, vol.3, pp.1253-1260, 2008. ,
Cholesterol crystals and inflammation, Curr Rheumatol Rep, vol.15, p.313, 2013. ,
Improving coronary heart disease risk assessment in asymptomatic people: role of traditional risk factors and noninvasive cardiovascular tests, Circulation, vol.104, pp.1863-1867, 2001. ,
, , 2012.
Plaque rupture and sudden death related to exertion in men with coronary artery disease, JAMA, vol.281, issue.10, pp.921-926, 1999. ,
Coronary calcification improves cardiovascular risk prediction in the elderly, Circulation, vol.112, issue.4, pp.572-577, 2005. ,
The dark and bright side of atherosclerotic calcification, Atherosclerosis, vol.238, issue.2, pp.220-230, 2015. ,
Advanced atherosclerotic lesions in the innominate artery of the ApoE knockout mouse, Arterioscler. Thromb. Vasc. Biol, vol.20, issue.12, pp.2587-2592, 2000. ,
Calcification of advanced atherosclerotic lesions in the innominate arteries of ApoE-deficient mice: potential role of chondrocyte-like cells, Arterioscler. Thromb. Vasc. Biol, vol.25, issue.7, pp.1420-1425, 2005. ,
Smooth muscle cell-specific runx2 deficiency inhibits vascular calcification, Circ. Res, vol.111, issue.5, pp.543-552, 2012. ,
DOI : 10.1161/circresaha.112.267237
URL : https://www.ahajournals.org/doi/pdf/10.1161/CIRCRESAHA.112.267237
Carotid and femoral atherosclerotic plaques show different morphology, Atherosclerosis, vol.216, issue.2, pp.348-354, 2011. ,
DOI : 10.1016/j.atherosclerosis.2011.02.004
URL : https://hal.archives-ouvertes.fr/inserm-00642808
Expression of cartilage-specific markers in calcified and non-calcified atherosclerotic lesions, Atherosclerosis, vol.196, issue.1, pp.37-41, 2008. ,
DOI : 10.1016/j.atherosclerosis.2007.01.020
The impact of calcification on the biomechanical stability of atherosclerotic plaques, Circulation, vol.103, issue.8, pp.1051-1056, 2001. ,
,
Spotty calcification typifies the culprit plaque in patients with acute myocardial infarction: an intravascular ultrasound study, Circulation, vol.110, issue.22, pp.3424-3429, 2004. ,
, Microcalcifications in early intimal lesions of atherosclerotic human coronary arteries, vol.178, pp.2879-2887, 2011.
Intra-section analysis of human coronary arteries reveals a potential role for micro-calcifications in macrophage recruitment in the early stage of atherosclerosis, PLoS One, vol.10, issue.11, 2015. ,
A hypothesis for vulnerable plaque rupture due to stress-induced debonding around cellular microcalcifications in thin fibrous caps, Proc. Natl. Acad. Sci. U. S. A, vol.103, issue.40, pp.14678-14683, 2006. ,
Revised microcalcification hypothesis for fibrous cap rupture in human coronary arteries, Proc. Natl. Acad. Sci. U. S. A, vol.110, issue.26, pp.10741-10746, 2013. ,
DOI : 10.1073/pnas.1308814110
URL : http://www.pnas.org/content/110/26/10741.full.pdf
Do cytokines induce vascular calcification by the mere stimulation of TNAP activity?, Med. Hypotheses, vol.75, issue.6, pp.517-521, 2010. ,
Multisystemic functions of alkaline phosphatases, Methods Mol. Biol, vol.1053, pp.27-51, 2013. ,
URL : https://hal.archives-ouvertes.fr/hal-00917994
Inflammation: a culprit for vascular calcification in atherosclerosis and diabetes, Cell. Mol. Life Sci, pp.2475-2489, 2015. ,
URL : https://hal.archives-ouvertes.fr/hal-01414372
Cell-specific effects of TNF-? and IL-1? on alkaline phosphatase: implication for syndesmophyte formation and vascular calcification, Lab. Investig, vol.91, issue.10, pp.1434-1442, 2011. ,
Tumor necrosis factor-alpha promotes in vitro calcification of vascular cells via the cAMP pathway, Circulation, vol.102, issue.21, pp.2636-2642, 2000. ,
Induction of bone-type alkaline phosphatase in human vascular smooth muscle cells: roles of tumor necrosis factor-alpha and oncostatin M derived from macrophages, Circ. Res, vol.91, issue.1, pp.9-16, 2002. ,
Tumor necrosis factor-alpha increases alkaline phosphatase expression in vascular smooth muscle cells via MSX2 induction, Biochem. Biophys. Res. Commun, vol.391, issue.1, pp.1087-1092, 2010. ,
Pathophysiological role of vascular smooth muscle alkaline phosphatase in medial artery calcification, J. Bone Miner. Res, pp.824-836, 2015. ,
Primary culture and phenotyping of murine chondrocytes, Nat. Protoc, vol.3, issue.8, pp.1253-1260, 2008. ,
Bone Gla protein increases HIF-1alphadependent glucose metabolism and induces cartilage and vascular calcification, Arterioscler. Thromb. Vasc. Biol, vol.31, issue.9, pp.55-71, 2011. ,
Glucose stimulates chondrocyte differentiation of vascular smooth muscle cells and calcification: a possible role for IL-1?, FEBS Lett, pp.2797-2804, 2015. ,
URL : https://hal.archives-ouvertes.fr/hal-01414233
Tissue-nonspecific alkaline phosphatase promotes axonal growth of hippocampal neurons, Mol. Biol. Cell, vol.22, issue.7, pp.1014-1024, 2011. ,
Characterization and kinetic analysis of the intracellular domain of human protein tyrosine phosphatase beta (HPTP beta) using synthetic phosphopeptides, Biochem. J, vol.298, issue.2, pp.395-401, 1994. ,
Apatite content of collagen materials dose-dependently increases pre-osteoblastic cell deposition of a cement line-like matrix, Bone, vol.47, issue.1, pp.23-33, 2010. ,
TNF-alpha and IL-1beta inhibit RUNX2 and collagen expression but increase alkaline phosphatase activity and mineralization in human mesenchymal stem cells, Life Sci, vol.84, pp.499-504, 2009. ,
Aggrecan is required for growth plate cytoarchitecture and differentiation, Dev. Biol, vol.396, issue.2, pp.224-236, 2014. ,
Normal long bone growth and development in type X collagen-null mice, Nat. Genet, vol.8, issue.2, pp.129-135, 1994. ,
Endocrine regulation of energy metabolism by the skeleton, Cell, vol.130, issue.3, pp.456-469, 2007. ,
Chondrogenesis mediated by PPi depletion promotes spontaneous aortic calcification in NPP1?/? mice, Arterioscler. Thromb. Vasc. Biol, vol.25, issue.4, pp.686-691, 2005. ,
Nature of phosphate substrate as a major determinant of mineral type formed in matrix vesicle-mediated in vitro mineralization: an FTIR imaging study, Bone, vol.38, issue.6, pp.811-817, 2006. ,
Pyrophosphate inhibits mineralization of osteoblast cultures by binding to mineral, up-regulating osteopontin, and inhibiting alkaline phosphatase activity, J. Biol. Chem, vol.282, issue.21, pp.15872-15883, 2007. ,
Phosphate-dependent stimulation of MGP ,
, Biochimica et Biophysica Acta, vol.1863, pp.643-653, 2017.
, OPN expression in osteoblasts via the ERK1/2 pathway is modulated by calcium, Bone, vol.48, issue.4, pp.894-902, 2011.
Hyperphosphatemia-induced nanocrystals upregulate the expression of bone morphogenetic protein-2 and osteopontin genes in mouse smooth muscle cells in vitro, Kidney Int, vol.79, issue.4, pp.414-422, 2011. ,
Phosphate is a specific signal for ATDC5 chondrocyte maturation and apoptosis-associated mineralization: possible implication of apoptosis in the regulation of endochondral ossification, J. Bone Miner. Res, vol.18, issue.8, pp.1430-1442, 2003. ,
URL : https://hal.archives-ouvertes.fr/inserm-00176537
Mineral surface in calcified plaque is like that of bone: further evidence for regulated mineralization, Arterioscler. Thromb. Vasc. Biol, vol.28, issue.11, pp.2030-2034, 2008. ,
The "bone morphogenic proteins" pathways in bone and joint diseases: translational perspectives from physiopathology to therapeutic targets, Cytokine Growth Factor Rev, vol.24, issue.1, pp.69-81, 2013. ,
Osteogenesis associates with inflammation in earlystage atherosclerosis evaluated by molecular imaging in vivo, Circulation, vol.116, issue.24, pp.2841-2850, 2007. ,
DOI : 10.1161/circulationaha.107.732867
URL : https://www.ahajournals.org/doi/pdf/10.1161/CIRCULATIONAHA.107.732867
Macrophage-derived matrix vesicles: an alternative novel mechanism for microcalcification in atherosclerotic plaques, Circ. Res, vol.113, issue.1, pp.72-77, 2013. ,
Phagocytosis of apoptotic cells by macrophages is impaired in atherosclerosis, Arterioscler. Thromb. Vasc. Biol, vol.25, issue.6, pp.1256-1261, 2005. ,
How dying cells alert the immune system to danger, Nat. Rev. Immunol, vol.8, issue.4, pp.279-289, 2008. ,
DOI : 10.1038/nri2215
URL : http://europepmc.org/articles/pmc2763408?pdf=render
Apoptosis regulates human vascular calcification in vitro: evidence for initiation of vascular calcification by apoptotic bodies, Circ. Res, vol.87, issue.11, pp.1055-1062, 2000. ,
Multiple functions of MSCA-1/TNAP in adult mesenchymal progenitor/stromal cells, Stem Cells Int, p.1815982, 2016. ,
Alkaline phosphatase in stem cells, Stem Cells Int, p.628368, 2015. ,
Unique coexpression in osteoblasts of broadly expressed genes accounts for the spatial restriction of ECM mineralization to bone, Genes Dev, vol.19, issue.9, pp.1093-1104, 2005. ,
Type I collagen gene expression in human atherosclerosis. Localization to specific plaque regions, Am. J. Pathol, vol.143, issue.6, pp.1634-1648, 1993. ,
Focal arterial inflammation precedes subsequent calcification in the same location: a longitudinal FDG-PET/CT study, Circ. Cardiovasc. Imaging, vol.6, issue.5, pp.747-754, 2013. ,
)Ffluoride positron emission tomography for identification of ruptured and high-risk coronary atherosclerotic plaques: a prospective clinical trial, Lancet, issue.18, pp.705-713, 2013. ,
Inhibitors of tissue-nonspecific alkaline phosphatase: design, synthesis, kinetics, biomineralization and cellular tests, Bioorg. Med. Chem, pp.7981-7987, 2013. ,
URL : https://hal.archives-ouvertes.fr/hal-00917962
Novel inhibitors of alkaline phosphatase suppress vascular smooth muscle cell calcification, J. Bone Miner. Res, vol.22, issue.11, pp.1700-1710, 2007. ,
Sortilin mediates vascular calcification via its recruitment into extracellular vesicles, J. Clin. Invest, vol.126, issue.4, pp.1323-1336, 2016. ,
DOI : 10.1172/jci80851
URL : http://www.jci.org/articles/view/80851/files/pdf
Tissue-nonspecific alkaline phosphatase and plasma cell membrane glycoprotein-1 are central antagonistic regulators of bone mineralization, Proc. Natl. Acad. Sci. U. S. A, vol.99, issue.14, pp.9445-9449, 2002. ,
PC-1 nucleoside triphosphate pyrophosphohydrolase deficiency in idiopathic infantile arterial calcification, Am. J. Pathol, vol.158, issue.2, pp.543-554, 2001. ,
Treatment with pyrophosphate inhibits uremic vascular calcification, Kidney Int, vol.79, issue.5, pp.512-517, 2011. ,
Daily peritoneal administration of sodium pyrophosphate in a dialysis solution prevents the development of vascular calcification in a mouse model of uraemia, Nephrol. Dial. Transplant, vol.26, issue.10, pp.3349-3357, 2011. ,
Rat aortic smooth muscle cells cultured on hydroxyapatite differentiate into osteoblast-like cells via BMP2-SMAD-5 pathway, Calcif. Tissue Int, vol.96, issue.4, pp.359-369, 2015. ,
DOI : 10.1007/s00223-015-9962-z
URL : http://europepmc.org/articles/pmc4393885?pdf=render
Bone: formation by autoinduction, Science, vol.150, issue.3698, pp.893-899, 1965. ,
DOI : 10.1097/00003086-200202000-00002
Bone morphogenetic protein, J. Dent. Res, vol.50, issue.6, pp.1392-1406, 1971. ,
Elastin haploinsufficiency impedes the progression of arterial calcification in MGPdeficient mice, J. Bone Miner. Res, vol.29, issue.2, pp.327-337, 2014. ,
Analysis of intimal proteoglycans in atherosclerosis-prone and atherosclerosis-resistant human arteries by mass spectrometry, Mol. Cell. Proteomics, vol.4, issue.9, pp.1350-1357, 2005. ,
Tissue-nonspecific alkaline phosphatase deficiency causes abnormal craniofacial bone development in the Alpl(?/?) mouse model of infantile hypophosphatasia, Bone, vol.67, pp.81-94, 2014. ,
Inactivation of two mouse alkaline phosphatase and establishment of a model of infantile hypophosphatasia, Dev. Dyn, vol.208, issue.3, pp.432-446, 1997. ,
, Arterioscler. Thromb. Vasc. Biol, vol.28, issue.11, pp.2030-2034, 2008.
, PLoS One, vol.10, p.142335, 2015.
, Proc. Natl. Acad. Sci. U. S. A, vol.110, issue.26, pp.10741-10746, 2013.
, Circulation, vol.110, pp.3424-3429, 2004.
, Ann. Biomed. Eng, vol.38, pp.738-747, 2010.
, Genes Dev, vol.19, issue.9, pp.1093-1104, 2005.
, J. Bone Miner. Res, vol.30, issue.5, pp.824-836, 2015.
, Biochim. Biophys. Acta, vol.863, issue.3, pp.643-653, 2017.
, PLoS One, vol.12, issue.10, p.186426, 2017.
, Methods Mol. Biol, vol.1053, pp.27-51, 2013.
, J. Bone Miner. Res, vol.28, pp.1587-1598, 2013.
, J. Bone Miner. Res, vol.18, pp.117-125, 2003.
, Proc. Natl. Acad. Sci. U. S. A, vol.99, pp.9445-9449, 2002.
, Osteoarthr. Cartil, vol.17, pp.64-72, 2009.
, Biochim. Biophys. Acta, vol.1862, issue.3, pp.532-546, 2017.
, PLoS One, vol.9, p.107482, 2014.
, Postepy Biochem, vol.53, pp.159-163, 2007.
, J. Biol. Chem, vol.275, issue.45, pp.35577-35583, 2000.
, J. Biol. Chem, vol.287, pp.14803-14815, 2012.
, J. Clin. Invest, vol.126, issue.4, pp.1323-1336, 2016.
, Arterioscler. Thromb. Vasc. Biol, vol.37, issue.5, pp.1005-1011, 2017.
, J. Bone Miner. Res, vol.23, issue.11, pp.1798-1805, 2008.
, J. Cell. Mol. Med, vol.12, issue.5B, pp.2073-2082, 2008.
, Circ. Res, vol.109, issue.1, pp.1-12, 2011.
, J. Extracell. Vesicles, vol.3, p.25129, 2014.
, Biochim. Biophys. Acta, vol.1828, pp.602-613, 2013.
, Biochim. Biophys. Acta, vol.409, issue.1, pp.128-143, 1975.
, Methods Mol. Biol, vol.1053, pp.115-124, 2013.
,
, , vol.589, pp.2797-2804, 2015.
, Bone Miner, vol.19, issue.3, pp.287-298, 1992.
, Histochem. Cell Biol, vol.107, issue.3, pp.183-191, 1997.
, Lab. Investig, vol.91, issue.10, pp.1434-1442, 2011.
, Postepy Biochem, vol.62, pp.511-517, 2016.
, J. Biol. Chem, vol.283, issue.15, pp.9737-9748, 2008.
, J. Am. Soc. Nephrol, vol.15, issue.11, pp.2857-2867, 2004.
, J. Bone Miner. Res, vol.16, issue.4, pp.750-777, 2001.
, Bone, vol.29, issue.6, pp.547-552, 2001.
, Experientia, vol.40, pp.836-837, 1984.
, Circulation, vol.110, issue.14, pp.1953-1959, 2004.
, Atherosclerosis, vol.238, pp.220-230, 2015.
,
Osteoporosis-a current view of pharmacological prevention and treatment, Drug Des. Devel. Ther, vol.7, pp.435-448, 2013. ,
The mechanism of mineralization and the role of alkaline phosphatase in health and disease, J. Nippon Med. Sch, vol.77, pp.4-12, 2010. ,
The role of matrix vesicles in physiological and pathological calcification, Curr. Opin. Orthop, vol.18, pp.428-433, 2007. ,
Physiological role of alkaline phosphatase explored in hypophosphatasia, Ann. N. Y. Acad. Sci, vol.192, pp.190-200, 2010. ,
Role of extracellular membrane vesicles in the pathogenesis of various diseases, including cancer, renal diseases, atherosclerosis, and arthritis, Lab. Invest, vol.90, pp.1549-1557, 2011. ,
Ankylosingspondylarthritis, late osteoarthritis, vascular calcification, chondrocalcinosis and pseudo gout: Toward a possible drug therapy, Curr. Med. Chem, vol.18, pp.2196-2203, 2011. ,
DOI : 10.2174/092986711795656153
Spondyloarthropathy in progressive ankylosis mice: ultrastructural features of the interverterbral disk, Acta Anat. (Basel), pp.36-41, 1991. ,
Apatite crystal nodules in arthritic cartilage, Eur. J. Rheumatol. Inflamm, vol.14, pp.115-119, 1978. ,
DOI : 10.1016/8756-3282(85)90277-7
Cartilage formation in growth plate and arteries: from physiology to pathology, Bioessays, vol.27, pp.708-716, 2005. ,
DOI : 10.1002/bies.20254
Molecular mechanisms of vascular calcification: lessons learned from the aorta, Arterioscler. Thromb. Vasc. Biol, vol.26, pp.1423-1430, 2006. ,
Role of extracellular vesicles in de novo mineralization. An additional novel mechanism of cardiovascular calcification, Arterioscler. Thromb. Vasc. Biol, vol.33, pp.1753-1758, 2013. ,
Medial arterial calcification and its association with mortality and complications of diabetes, Diabetologia, vol.31, pp.16-23, 1988. ,
Medial artery calcification. A neglected harbinger of cardiovascular complications in non-insulin-dependent diabetes mellitus, Arterioscler. Thromb. Vasc. Biol, vol.16, pp.978-983, 1996. ,
DOI : 10.1161/01.atv.16.8.978
Mechanisms of lumen enlargement after excimer laser coronary angioplasty. An intravascular ultrasound study, Circulation, vol.92, pp.3408-3414, 1995. ,
DOI : 10.1161/01.cir.92.12.3408
Calcification in atherosclerotic plaque of human carotid arteries: associations with mast cells and macrophages, J. Pathol, vol.185, pp.10-17, 1998. ,
Osteogenic differentiation regulated by Rhokinase in periodontal ligament cells, Differentiation, vol.88, pp.33-41, 2014. ,
DOI : 10.1016/j.diff.2014.09.002
Biology and pathology of Rho GTPAse, PI-3 Kinase-A and MAP kinase signaling pathways in chondrocytes, J. Cell. Biochem, vol.110, pp.573-580, 2010. ,
Cell shape, cytoskeletal tension, and RhoA regulate stem cell lineage commitment, Dev. Cell, vol.6, pp.483-495, 2004. ,
Molecular mechanisms of mesenchymal stem cell differentiation towards osteoblasts, World J Stem Cells, vol.5, pp.136-148, 2013. ,
DOI : 10.4252/wjsc.v5.i4.136
URL : https://hal.archives-ouvertes.fr/hal-00917978
Osteoclasts: what do they do and how do they do it?, Am. J. Pathol, vol.170, pp.427-435, 2007. ,
Osteoclast-derived activity in the coupling of bone formation to resorption, Trends Mol. Med, vol.11, pp.76-81, 2005. ,
Are nonresorbing osteoclasts sources of bone anabolic activity?, J. Bone Miner. Res, vol.22, pp.487-494, 2007. ,
DOI : 10.1359/jbmr.070109
URL : http://onlinelibrary.wiley.com/doi/10.1359/jbmr.070109/pdf
, Membrane trafficking in osteoblasts and osteoclasts: new avenues for understanding and treating skeletal diseases, vol.13, pp.1307-1314, 2012.
DOI : 10.1111/j.1600-0854.2012.01395.x
URL : http://onlinelibrary.wiley.com/doi/10.1111/j.1600-0854.2012.01395.x/pdf
The role of bone marrow microenvironment in governing the balance between osteoblastogenesis and adipogenesis, Aging Dis, issue.7, pp.514-525, 2015. ,
Quantifying osteoblast and osteocyte apoptosis: challenges and rewards, J. Bone Miner. Res, vol.22, pp.1492-1501, 2007. ,
DOI : 10.1359/jbmr.070518
URL : http://onlinelibrary.wiley.com/doi/10.1359/jbmr.070518/pdf
Osteocyte apoptosis, Bone, vol.54, pp.264-271, 2013. ,
DOI : 10.1016/j.bone.2012.11.038
URL : http://europepmc.org/articles/pmc3624050?pdf=render
, Biochimica et Biophysica Acta, vol.1861, pp.1009-1023, 2017.
Chondrocytes, mesenchymal stem cells, and their combination in articular cartilage regenerative medicine, Ann. Biomed. Eng, vol.44, pp.1325-1354, 2016. ,
Evolving concepts of chondrogenic differentiation: history, state-of-the-art and future perspectives, Eur. Cell. Mater, vol.30, pp.12-27, 2015. ,
Heritable diseases of the skeleton. Part I: molecular insights into skeletal development-transcription factors and signaling pathways, FASEB J, vol.11, pp.125-132, 1997. ,
Heritable diseases of the skeleton. Part II: molecular insights into skeletal development-matrix components and their homeostasis, FASEB J, vol.11, pp.227-233, 1997. ,
The genetic basis for skeletal diseases, Nature, vol.423, pp.343-348, 2003. ,
What old means to bone, Trends Endocrinol. Metab, pp.369-374, 2010. ,
Osteocytes are not only mechanoreceptive cells, Int. J. Numer. Methods Biomed. Eng, vol.29, pp.1082-1088, 2013. ,
A review of osteocyte function and the emerging importance of sclerostin, J. Bone Joint Surg. Am, vol.96, pp.1659-1668, 2014. ,
Mouse models for the evaluation of osteocyte functions, J. Bone Metab, vol.21, pp.55-60, 2014. ,
For whom the bell tolls: distress signals from longlived osteocytes and the pathogenesis of metabolic bone diseases, Bone, vol.54, pp.272-278, 2013. ,
Osteocytes, not osteoblasts or lining cells, are the main source of the RANKL required for osteoclast formation in remodeling bone, PLoS One, vol.10, p.138189, 2015. ,
Immunogold localization of beta 1-integrin in bone: effect of glucocorticoids and insulin-like growth factor I on integrins and osteocyte formation, J. Histochem. Cytochem, vol.43, pp.1085-1096, 1995. ,
Adhesive properties of iso-lated chick osteocytes in vitro, Bone, vol.18, pp.305-313, 1996. ,
Ultra-structure of the osteocyte process and its pericellular matrix, Anat. Rec, vol.278, pp.505-513, 2004. ,
Podosomes are dispensable for osteoclast differentiation and migration, Eur. J. Cell Biol, vol.92, pp.139-149, 2013. ,
Modulation of osteoclast differentiation and bone resorption by Rho GTPases, Small GTPases, vol.5, p.28119, 2014. ,
The regulation of osteoclast function and bone resorption by small GTPases, Small GTPases, vol.2, pp.117-130, 2011. ,
Integrin function: molecular hierarchies of cytoskeletal and signaling proteins, J. Cell Biol, vol.131, pp.791-805, 1995. ,
Focal adhesion kinase: a regulator of focal adhesion dynamics and cell movement, Oncogene, vol.19, pp.5606-5613, 2000. ,
Integrins and GTPases in tumour cell growth, motility and invasion, Trends Cell Biol, vol.8, pp.101-106, 1998. ,
Signaling pathways effecting crosstalk between cartilage and adjacent tissues: seminars in cell and developmental biology: the biology and pathology of cartilage, Semin. Cell Dev. Biol, pp.1084-9521, 2016. ,
Regulatory mechanisms in the pathways of cartilage and bone formation, Curr. Opin. Cell Biol, vol.13, pp.721-727, 2001. ,
Functional differences between growth plate apoptic bodies and matrix vesicles, J. Bone Miner. Res, vol.18, pp.1872-1881, 2003. ,
Expression of collagenase-3 (matrix metalloproteinase-13) in squamous cell carcinomas of the head and neck, Am. J. Pathol, vol.151, pp.499-508, 1997. ,
Expression of early and late differentiation markers (proliferating cell nuclear antigen, syndecan-3, annexin VI, and alkaline phosphatase) by human osteoarthritic chondrocytes, Am. J. Pathol, vol.159, pp.1777-1783, 2001. ,
Critical roles for collagenase-3 (Mmp13) in development of growth plate cartilage and in endochondrial ossification, Proc. Natl. Acad. Sci. U. S. A, vol.101, pp.17192-17197, 2004. ,
Annexin 2 is a phosphatidylinositol (4,5)-bisphosphate binding protein recruited to actin assembly sites at cellular membranes, J. Cell Sci, vol.117, pp.3473-3480, 2004. ,
Proteome analysis of matrix vesicles isolated from femurs of chicken embryo, Proteomics, vol.8, pp.192-205, 2008. ,
Articular cartilage calcification and matrix vesicles, Curr. Rheumatol. Rep, vol.4, pp.265-269, 2002. ,
Matrix vesicles and calcification, Curr. Rheumatol. Rep, vol.5, pp.222-226, 2003. ,
Isolation and characterization of calcifying matrix vesicles from epiphyseal cartilage, Proc. Natl. Acad. Sci. U. S. A, vol.167, pp.1513-1520, 1970. ,
Studies on matrix vesicles isolated from chick epiphyseal cartilage. Association of pyrophosphatase and ATPase activities with alkaline phosphatase, Biochim. Biophys. Acta, vol.60, pp.51-60, 1975. ,
Nonenzymatic method for isolation of matrix vesicles: characterization and initial studies on Ca and P orthophosphate metabolism, Metab. Bone Dis. Relat. Res, vol.1, pp.125-136, 1978. ,
Subcellular fractionation of epiphyseal cartilage: isolation of matrix vesicles and profiles of enzymes, phospholipids, calcium and phosphate, Biochim. Biophys. Acta, vol.631, pp.289-304, 1980. ,
Stimulation of calcification of growth plate cartilage matrix vesicles by binding to type II and X collagens, J. Biol. Chem, vol.269, pp.11462-11469, 1994. ,
A comparative analysis of strategies for isolation of matrix vesicles, Anal. Biochem, vol.361, pp.176-182, 2007. ,
URL : https://hal.archives-ouvertes.fr/hal-00139316
Isolation and characteristics of matrix vesicles, Methods Mol. Biol, vol.1053, pp.115-124, 2013. ,
URL : https://hal.archives-ouvertes.fr/hal-00917990
The mechanism of matrix vesicle formation. Studies on the composition of chondrocyte microvilli and on the effects of microfilament-pertubing agents on cellular vesiculation, J. Biol. Chem, vol.262, pp.1916-1925, 1987. ,
Matrix vesicles originate from apical membrane microvilli of mineralizing osteoblast-like Saos-2 cells, J. Cell. Biochem, vol.106, pp.127-138, 2009. ,
URL : https://hal.archives-ouvertes.fr/hal-00353017
Proteomic characterization of biogenesis and functions of matrix vesicles released from mineralizing human osteoblast-like cells, J. Proteomics, vol.74, pp.1123-1134, 2011. ,
URL : https://hal.archives-ouvertes.fr/hal-00599337
Role of matrix vesicles in biomineralization, Biochim. Biophys. Acta, vol.1790, pp.1592-1598, 2009. ,
Matrix vesicles: structure, composition, formation and function in calcification, Front. Biosci, vol.16, pp.2812-2902, 2011. ,
Matrix vesicles: are they anchored exosomes, Bone, vol.79, pp.29-36, 2015. ,
Tissue-nonspecific alkaline phosphatase and plasma cell membrane glycoprotein-1 are central antagonistic regulators of bone mineralization, Proc. Natl. Acad. Sci. U. S. A, vol.99, pp.9445-9449, 2002. ,
Concerted regulation of inorganic pyrophosphate and osteopontin by Akp2, Enpp1, and Ank: an integrated model of the pathogenesis of mineralization disorders, Am. J. Pathol, vol.164, pp.1199-1209, 2004. ,
Alkaline phosphatase and hypophosphatasia, Calcif. Tissue Int, vol.98, pp.398-416, 2016. ,
Calcium regulates key components of vascular smooth muscle cell-derived matrix vesicles to enhance mineralization, Circ. Res, vol.109, pp.1-12, 2011. ,
DOI : 10.1161/circresaha.110.238808
URL : https://www.ahajournals.org/doi/pdf/10.1161/CIRCRESAHA.110.238808
Connective tissue growth factor induces osteogenic differentiation of vascular smooth muscle cells through ERK signaling, Int. J. Mol. Med, vol.32, pp.423-429, 2013. ,
Protein kinase N (PKN) and PKN-related protein rhophilin as targets of small GTPase Rho, Science, vol.271, pp.645-648, 1996. ,
DOI : 10.1126/science.271.5249.645
Physiological roles of Rho and Rho effectors in mammals, Eur. J. Cell Biol, vol.92, pp.303-315, 2013. ,
Involvement of Rho GTPases and their regulators in the pathogenesis of hypertension, Small GTPases, vol.5, p.983666, 2014. ,
Rho GTPases in cell biology, Nature, vol.420, pp.629-635, 2002. ,
DOI : 10.1038/nature01148
Rho GTPases and the actin cytoskeleton, Science, vol.279, pp.509-514, 1998. ,
Identification of an evolutionarily conserved super-family of DOCK180-related proteins with guanine nucleotide exchange activity, J. Cell Sci, vol.115, pp.4901-4913, 2002. ,
CZH proteins: a new family of Rho-GEFs, J. Cell Sci, vol.118, pp.4937-4946, 2005. ,
The Rac1 exchange factor Dock5 is essential for bone resorption by osteoclasts, J. Bone Miner. Res, vol.26, pp.1099-1110, 2011. ,
URL : https://hal.archives-ouvertes.fr/hal-00657347
Rho-associated coiled-coil containing kinases (ROCK): structure, regulation, and functions, Small GTPases, vol.5, p.29846, 2014. ,
Rho-associated coiled-coil kinase (ROCK) signaling and disease, Crit. Rev. Biochem. Mol. Biol, vol.48, pp.301-316, 2013. ,
DOI : 10.3109/10409238.2013.786671
The function of Rho-associated kinases ROCK1 and ROCK2 in the pathogenesis of cardiovascular disease, Front. Pharmacol, vol.276, pp.1-16, 2015. ,
Advances in the development of Rho-associated protein kinase (ROCK) inhibitors, Drug Discov. Today, vol.18, pp.1323-1333, 2013. ,
The nuts and bolts of AGC protein kinases, Nat. Rev. Mol. Cell Biol, vol.11, pp.9-22, 2010. ,
A novel serine/threonine kinase binding the Rasrelated RhoA GTPase which translocates the kinase to peripheral membranes, J. Biol. Chem, vol.270, pp.29051-29054, 1995. ,
The small GTP-binding protein Rho binds to and activates a 160 kDa Ser/Thr protein kinase homologous to myotonic dystrophy kinase, EMBO J, vol.15, pp.1885-1893, 1996. ,
, Biochimica et Biophysica Acta, vol.1861, pp.1009-1023, 2017.
The p160 RhoA-binding kinase ROK alpha is a member of a kinase family and is involved in the reorganization of the cytoskeleton, Mol. Cell. Biol, vol.16, pp.5313-5327, 1996. ,
Formation of actin stress fibers and focal adhesions enhanced by Rho-kinase, Science, vol.275, pp.1308-1311, 1997. ,
DOI : 10.1126/science.275.5304.1308
Regulation and functions of Rho-associated kinase, Exp. Cell Res, vol.261, pp.44-51, 2000. ,
two isoforms of Rho-associated coiled-coil forming protein serine/threonine kinase in mice, FEBS Lett, vol.392, pp.189-193, 1996. ,
Rho-kinase inhibitors as therapeutics: from pan inhibition to isoform selectivity, Cell. Mol. Life Sci, vol.67, pp.171-177, 2010. ,
Structure basis and unconventional lipid membrane binding properties of the PH-C1 tandem of rho kinases, J. Biol. Chem, vol.283, pp.26263-26273, 2008. ,
Rocks: multifunctional kinases in cell behaviors, Nat. Rev. Mol. Cell Biol, vol.4, pp.446-456, 2003. ,
Rho-associated coiled-coil containing kinases (ROCK) structure, regulation and functions, Small GTPases, vol.5, p.229846, 2014. ,
The Rho kinases I and II regulate different aspects of myosin II activity, J. Cell Biol, vol.170, pp.443-453, 2005. ,
Rho-associated kinase, a novel serine/threonine kinase, as a putative target for small GTP binding protein Rho, EMBO J, vol.15, pp.2208-2216, 1996. ,
RhoA-binding kinase alpha translocation is facilitated by the collapse of the vimentin, Mol. Cell. Biol, vol.18, pp.6325-6339, 1998. ,
Rho-kinase-mediated contraction of isolated stress fibers, J. Cell Biol, vol.153, pp.569-584, 2001. ,
Interaction of Rho-kinase with myosin II at stress fibers, Genes Cells, vol.9, pp.653-660, 2004. ,
Interaction between ROCK II and nucleophosmin/B23 in the regulation of centrosome duplication, Mol. Cell. Biol, vol.26, pp.9016-9034, 2006. ,
Nuclear Rho kinase, ROCK2, targets p300 acetyltransferase, J. Biol. Chem, vol.281, pp.15320-15329, 2006. ,
Distinct distribution and localization of Rho-kinase in mouse epithelial, muscle and neural tissues, Cell Struct. Funct, vol.37, pp.155-175, 2012. ,
The Rho-associated protein kinase p160ROCK is required for centrosome positioning, J. Cell Biol, vol.157, pp.807-817, 2002. ,
A Rho-associated kinase mitigates reperfusion-induced change in the shape of cardiac capillary endothelial cells in situ, Cardiovasc. Res, vol.57, pp.195-206, 2003. ,
Integrin cytoplasmic domain-associated protein-1 (ICAP-1) interacts with the ROCK-I kinase at the plasma membrane, J. Cell. Physiol, vol.208, pp.620-628, 2006. ,
Phosphorylation and activation of myosin by Rho-associated kinase, J. Biol. Chem, vol.271, pp.20246-20249, 1996. ,
Regulation of myosin phosphatase by Rho and Rho-associated kinase (Rho-kinase), Science, vol.273, pp.245-248, 1996. ,
Phosphorylation of myosin-binding subunit (MBS) of myosin phosphatase by Rho-kinase in vivo, J. Cell Biol, vol.147, pp.1023-1038, 1999. ,
Regulation of glucose transport by ROCK1 differs from that of ROCK2 and is controlled by actin polymerization, Endocrinology, vol.153, pp.1649-1662, 2012. ,
Rho-associated kinase directly induces smooth muscle contraction through myosin light chain phosphorylation, J. Biol. Chem, vol.272, pp.12257-12260, 1997. ,
DOI : 10.1074/jbc.272.19.12257
URL : http://www.jbc.org/content/272/19/12257.full.pdf
Signaling from Rho to the actin cytoskeleton through protein kinases ROCK and LIM-kinase, Science, vol.285, pp.895-898, 1999. ,
DOI : 10.1126/science.285.5429.895
Rho-associated kinase ROCK activates LIM-kinase 1 by phosphorylation at threonine 508 within the activation loop, J. Biol. Chem, vol.275, pp.3577-3582, 2000. ,
DOI : 10.1074/jbc.275.5.3577
URL : http://www.jbc.org/content/275/5/3577.full.pdf
Specific activation of LIM kinase 2 via phosphorylation of threonine 505 by ROCK, a Rho-dependent protein kinase, J. Biol. Chem, vol.276, pp.670-676, 2001. ,
LIM-kinase 2 induces formation of stress fibres, focal adhesions and membrane blebs, dependent on its activation by Rho-associated kinase-catalysed phosphorylation at threonine-505, Biochem. J, vol.354, pp.149-159, 2001. ,
Rho-ROCK-LIMKcofilin pathway regulates shear stress activation of sterol regulatory element binding proteins, Circ. Res, vol.92, pp.1296-1304, 2003. ,
DOI : 10.1161/01.res.0000078780.65824.8b
URL : http://circresaha.smart01.highwire.org/content/circresaha/92/12/1296.full.pdf
Rho-kinase phosphorylates COOH-terminal threonines of ezrin/radixin/ moesin (ERM) proteins and regulates their head-to-tail association, J. Cell Biol, vol.140, pp.647-657, 1998. ,
DOI : 10.1083/jcb.140.3.647
URL : http://jcb.rupress.org/content/jcb/140/3/647.full.pdf
Phosphorylation of adducin by Rho-kinase plays a crucial role in cell motility, J. Cell Biol, vol.145, pp.347-361, 1999. ,
Simvastatin exerts cardioprotective effects and inhibits the activity of Rho-associated protein kinase in rats with metabolic syndrome, Clin. Exp. Pharmacol. Physiol, vol.39, pp.759-764, 2012. ,
Calcium sensitization of smooth muscle mediated by a Rho-associated protein kinase in hyper-tension, Nature, vol.1389, pp.990-994, 1997. ,
ROCK isoform regulation of myosin phosphatase and contractility in vascular smooth muscle cells, Circ. Res, vol.104, pp.531-540, 2009. ,
DOI : 10.1161/circresaha.108.188524
URL : http://circres.ahajournals.org/content/circresaha/104/4/531.full.pdf
Distinct roles for ROCK1 and ROCK2 in the regulation of cell detachment, Cell Death Dis, vol.4, p.483, 2013. ,
Opposing signaling of ROCK1 and ROCK2 determines the switching of substrate specificity and the mode of migration of glioblastoma cells, Mol. Neurobiol, vol.49, pp.900-915, 2014. ,
Rho kinases in cardiovascular physiology and pathophysiology: the effect of fasudil, J. Cardiovasc. Pharmacol, vol.62, pp.341-354, 2013. ,
Rho/Rho-associated kinase pathway in glaucoma, Int. J. Oncol, vol.43, pp.1357-1367, 2013. ,
Role of Rho kinases in abnormal and normal hematopoiesis, Curr. Opin. Hematol, vol.21, pp.271-275, 2014. ,
Chatting with the neighbors: crosstalk between Rho-kinase (ROCK) and other signaling pathways for treatment of neurological disorders, Front. Neurosci, vol.9, p.198, 2015. ,
Rho-associated kinase signaling and the cancer microenvironment: novel biological implications and therapeutic opportunities, Expert Rev. Mol. Med, vol.17, p.17, 2015. ,
DOI : 10.1017/erm.2015.17
URL : https://www.cambridge.org/core/services/aop-cambridge-core/content/view/B700039E2A908F3A2E6FF60FECD7AE0E/S1462399415000174a.pdf/div-class-title-rho-associated-kinase-signalling-and-the-cancer-microenvironment-novel-biological-implications-and-therapeutic-opportunities-div.pdf
Rho kinases and cardiac remodeling, Circ. J, vol.80, pp.1491-1498, 2016. ,
DOI : 10.1253/circj.cj-16-0433
URL : https://www.jstage.jst.go.jp/article/circj/80/7/80_CJ-16-0433/_pdf
Novel insights into the roles of Rho kinase in cancer, Arch. Immunol. Ther. Exp. (Warsz.), vol.64, pp.259-278, 2016. ,
Regulation of ROCK activity in cancer, J. Histochem. Cytochem, vol.61, pp.185-198, 2013. ,
Rho kinases in health and diseases: from basic science to translational research, Pharmacol. Rev, vol.67, pp.1074-1095, 2015. ,
DOI : 10.1124/pr.115.010595
URL : http://pharmrev.aspetjournals.org/content/67/4/1074.full.pdf
Genetic and pharmacological inhibition of Rho-associated kinase II enhances adipogenesis, J. Biol. Chem, vol.282, pp.29574-29583, 2007. ,
DOI : 10.1074/jbc.m705972200
URL : http://www.jbc.org/content/282/40/29574.full.pdf
Effect of inhibition of the ROCK isoform on RT2 malignant glioma cells, Anticancer Res, vol.30, pp.3509-3514, 2010. ,
ROCK1 and ROCK2 are required for non-small cell lung cancer anchorage-independent growth and invasion, Cancer Res, vol.72, pp.5338-5347, 2012. ,
DOI : 10.1158/0008-5472.can-11-2373
URL : http://cancerres.aacrjournals.org/content/canres/72/20/5338.full.pdf
Activation of Rho kinase isoforms in lung endothelial cells during inflammation, J. Immunol, vol.182, pp.2385-2394, 2009. ,
DOI : 10.4049/jimmunol.0802811
URL : http://www.jimmunol.org/content/jimmunol/182/4/2385.full.pdf
RhoA/ROCK signaling is essential for multiple aspects of VEGF-mediated angiogenesis, FASEB J, vol.24, pp.3186-3195, 2010. ,
DOI : 10.1096/fj.09-145102
URL : https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2923346/pdf
Rho kinase-2 activation in human endothelial cells drives lysophosphatidic acid-mediated expression of cell adhesion molecules via NF-kappaB p65, J. Biol. Chem, vol.285, pp.12536-12542, 2010. ,
ROCK1 & 2 perform overlapping and unique roles in angiogenesis and angiosarcoma tumor progression, Curr. Mol. Med, vol.13, pp.205-219, 2013. ,
DOI : 10.2174/156652413804486296
URL : http://europepmc.org/articles/pmc3580831?pdf=render
ROCK2 regulates bFGF-induced proliferation of SH-SY5Y cells through GSK-3? and ?-catenin pathway, Brain Res, vol.1492, pp.7-17, 2013. ,
DOI : 10.1016/j.brainres.2012.11.034
URL : https://eprints.lib.hokudai.ac.jp/dspace/bitstream/2115/52135/1/BR1492_7-17.pdf
Fibronectin matrix assembly requires distinct contributions from Rho kinases I and-I, Mol. Biol. Cell, vol.18, pp.66-75, 2007. ,
DOI : 10.1091/mbc.e06-08-0684
URL : http://www.molbiolcell.org/content/18/1/66.full.pdf
Molecular characterization of the effects of Y-27632, Cell Motil. Cytoskeleton, vol.64, pp.97-109, 2007. ,
ROCK1 induces ERK nuclear translocation in PDGF-BB-stimulated migration of rat vascular smooth muscle cells, IUBMB Life, vol.64, pp.194-202, 2012. ,
DOI : 10.1002/iub.598
URL : http://onlinelibrary.wiley.com/doi/10.1002/iub.598/pdf
Distinct roles for ROCK1 and ROCK2 in the differential regulation of adhesion complex turnover by ROCK1 and ROCK2, PLoS One, vol.4, p.8190, 2009. ,
Differential regulation of adhesion complex turnover by ROCK1 and ROCK2, PLoS One, vol.7, p.31423, 2012. ,
DOI : 10.1371/journal.pone.0031423
URL : https://doi.org/10.1371/journal.pone.0031423
ROCK1 and ROCK2 regulate epithelial polarization and geometric cell shape, Biol. Cell, vol.104, pp.435-451, 2012. ,
DOI : 10.1111/boc.201100093
, Biochimica et Biophysica Acta, vol.1861, pp.1009-1023, 2017.
ROCK-I regulates closure of the eyelids and ventral body wall by inducing assembly of actomyosin bundles, J. Cell Biol, vol.168, pp.941-953, 2005. ,
Targeted disruption of the mouse rho-associated kinase 2 gene results in intrauterine growth retardation and fetal death, Mol. Cell. Biol, vol.23, pp.5043-5055, 2003. ,
ROCK-I and ROCK-II cooperatively regulate closure of eyelid and ventral body wall in mouse embryo, Genes Cells, vol.10, pp.825-834, 2005. ,
Rho-associated kinase II (ROCKII) limits axonal growth after trauma within the adult mouse spinal cord, J. Neurosci, vol.29, pp.15266-15276, 2009. ,
Targeted disruption of ROCK1 causes insulin resistance in vivo, J. Biol. Chem, vol.284, pp.11776-11780, 2009. ,
Targeted deletion of ROCK1 protects the heart against pressure overload by inhibiting reactive fibrosis, FASEB J, vol.20, pp.916-925, 2006. ,
ROCK1 mediates leukocyte recruitment and neointima formation following vascular injury, J. Clin. Invest, vol.118, pp.1632-1644, 2008. ,
ROCK1 functions as a suppressor of inflammatory cell migration by regulating PTEN phosphorylation and stability, Blood, vol.115, pp.1785-1796, 2010. ,
Dinh-Xuan, Fasudil inhibits prostate cancer-induced angiogenesis in vitro, Oncol. Rep, vol.32, pp.2795-2802, 2014. ,
Rho-associated kinase signaling and the cancer microenvironment: novel biological implications and therapeutic opportunities, Expert Rev. Mol. Med, vol.17, p.17, 2015. ,
The regulatory roles of ROCK and MRCK kinases in the plasticity of cancer cell migration, Cancer Lett, vol.361, pp.185-196, 2015. ,
Understanding and targeting the Rho kinase pathway in erectile dysfunction, Nat. Rev. Urol, vol.11, pp.622-628, 2014. ,
An emerging treatment option for glaucoma: Rho kinase inhibitors, Clin. Ophthalmol, vol.8, pp.883-890, 2014. ,
The Rho kinases: critical mediators of multiple profibrotic processes and rational targets for new therapies for pulmonary fibrosis, Pharmacol. Rev, vol.67, pp.103-117, 2015. ,
Chatting with the neighbors: crosstalk between Rho-kinase (ROCK) and other signaling pathways for treatment of neurological disorders, Front. Neurosci, vol.9, p.198, 2015. ,
Axon growth inhibition by RhoA/ROCK in the central nervous system, Front. Neurosci, vol.8, p.338, 2014. ,
Metabolic actions of Rho-kinase in periphery and brain, Trends Endocrinol. Metab, vol.24, pp.506-514, 2013. ,
ROCK inhibition as a therapy for spinal muscular atrophy: understanding the repercussions on multiple cellular targets, Front. Neurosci, vol.8, p.271, 2014. ,
A review on ROCK-II inhibitors: from molecular modelling to synthesis, Bioorg. Med. Chem. Lett, vol.26, pp.2383-2391, 2016. ,
Advances in the development of Rho-associated protein kinase (ROCK) inhibitors, Drug Discov. Today, vol.18, pp.1323-1333, 2013. ,
Mechanism of action of a novel antivasospasm drug, HA1077, J. Pharmacol. Exp. Ther, vol.241, pp.1033-1040, 1987. ,
Use and properties of ROCK-specific inhibitor Y-27632, Methods Enzymol, vol.325, pp.273-284, 2000. ,
Novel insights into the roles of Rho kinase in cancer, Arch. Immunol. Ther. Exp. (Warsz, 2016. ,
Intra-arterial infusion of fasudil hydrochloride for treating vasospasm following subarachnoid hemorrhage, Acta Neurochir, vol.141, pp.13-19, 1999. ,
DOI : 10.1007/s007010050260
Efficacy of the additional use of ripasudil, a Rho-kinase inhibitor, Patients With Glaucoma Inadequately Controlled Under Maximum Medical Therapy, Glaucoma, 2016. ,
PG324CS201 Study Group. Fixed-dose combination of AR-13324 and latanoprost: a double-masked, 28-day, randomized, controlled study in patients with open-angle glaucoma or ocular hypertension, Br. J. Ophthalmol, vol.100, pp.339-344, 2016. ,
Moons, I. Stalmans, Rho kinase inhibitor AMA0526 improves surgical outcome in a rabbit model of glaucoma filtration surgery, Prog. Brain Res, vol.220, pp.283-297, 2015. ,
Comparative gene expression profiling in three primary human cell lines after treatment with a novel inhibitor of Rho kinase or atorvastatin, Blood Coagul. Fibrinolysis, vol.19, pp.709-718, 2008. ,
, Selective ROCK2 inhibition in focal cerebral ischemia, vol.1, pp.2-14, 2014.
Isoform-specific targeting of ROCK proteins in immune cells, Small GTPases, vol.7, pp.173-177, 2016. ,
Inhibition of intrahepatic metastasis of human hepatocellular carcinoma by Rho-associated protein kinase inhibitor Y-27632, Hepatology, vol.33, pp.577-581, 2001. ,
Wf-536 prevents tumor metastasis by inhibiting both tumor motility and angiogenic actions, Eur. J. Pharmacol, vol.459, pp.113-120, 2003. ,
DOI : 10.1016/s0014-2999(02)02869-8
Effect of Wf-536, a novel ROCK inhibitor, against metastasis of B16 melanoma, Cancer Chemother. Pharmacol, vol.52, pp.319-324, 2003. ,
Identification of novel ROCK inhibitors with anti-migratory and anti-invasive activities, Oncogene, vol.33, pp.550-555, 2014. ,
DOI : 10.1038/onc.2012.634
URL : http://europepmc.org/articles/pmc3977753?pdf=render
Bone morphogenetic protein-2-induced signaling and osteogenesis is regulated by cell shape, RhoA/ROCK, and cytoskeletal tension, Stem Cells Dev, vol.21, pp.1176-1186, 2012. ,
DOI : 10.1089/scd.2011.0293
URL : http://europepmc.org/articles/pmc3328763?pdf=render
Novel regulators of bone formation: molecular clones and activities, Science, vol.242, pp.1528-1534, 1982. ,
DOI : 10.1126/science.3201241
Solubilized and insolubilized bone morphogenetic protein, Proc. Natl. Acad. Sci. U. S. A, vol.76, pp.1828-1832, 1979. ,
DOI : 10.1073/pnas.76.4.1828
URL : http://www.pnas.org/content/76/4/1828.full.pdf
WNT5A induces osteogenic differentiation of human adipose stem cells via rho-associated kinase ROCK, Cytotherapy, vol.12, pp.924-932, 2010. ,
DOI : 10.3109/14653241003774011
Matrix stiffness regulation of integrin-mediated mechanotransduction during osteogenic differentiation of human mesenchymal stem cells, J. Bone Miner. Res, vol.26, pp.730-738, 2011. ,
DOI : 10.1002/jbmr.278
URL : http://onlinelibrary.wiley.com/doi/10.1002/jbmr.278/pdf
RhoA/Rho kinase signaling regulates transforming growth factor-?1-induced chondrogenesis and actin organization of synovium-derived mesenchymal stem cells through interaction with the Smad pathway, Int. J. Mol. Med, vol.30, pp.1119-1125, 2012. ,
Stem cell shape regulates a chondrogenic versus myogenic fate through Rac1 and N-cadherin, Stem Cells, vol.28, pp.564-572, 2010. ,
DOI : 10.1002/stem.308
URL : http://onlinelibrary.wiley.com/doi/10.1002/stem.308/pdf
Essential requirement for Rho family GTPase signaling in Pax3 induced mesenchymal-epithelial transition, Cell. Signal, vol.18, pp.1501-1514, 2006. ,
Activation of AMPkinase and inhibition of Rho-kinase induce the mineralization of osteoblastic MC3T3-E1 cells through endothelial NOS and BMP-2 expression, Am. J. Physiol. Endocrinol. Metab, vol.296, pp.139-146, 2008. ,
Stimulation of ectopic bone formation in response to BMP-2 by Rho kinase inhibitor: a pilot study, Clin. Orthop. Relat. Res, vol.467, pp.3087-3095, 2009. ,
Neogenin, a receptor for bone morphogenetic proteins, J. Biol. Chem, vol.286, pp.5157-5165, 2011. ,
Inhibition of Rac1 promotes BMP2 induced osteoblastic differentiation, Cell Death Dis, vol.27, p.698, 2013. ,
Parathyroid hormone regulation of hypoxia-inducible factor signaling in osteoblastic cells, Bone, vol.81, pp.97-103, 2015. ,
, P2Y2 receptors regulate osteoblast mechanosensitivity during fluid flow, vol.306, pp.1058-1067, 2014.
P2X7 receptor function in bone-related cancer, J. Osteoporos, vol.2012, p.637863, 2012. ,
Reduced bone turnover in mice lacking the P2Y13 receptor of ADP, Mol. Endocrinol, vol.26, pp.142-152, 2012. ,
ROCK-generated contractility regulates breast epithelial cell differentiation in response to the physical properties of a three-dimensional collagen matrix, J. Cell Biol, vol.163, pp.583-595, 2003. ,
Molecular and mechano-biology of collagen gel contraction mediated by human MG-63 cells: involvement of specific intracellular signaling pathways and the cytoskeleton, Biochem. Cell Biol, vol.87, pp.895-904, 2009. ,
The RhoA-ROCK-PTEN pathway as a molecular switch for anchorage dependent cell behavior, Biomaterials, vol.33, pp.2902-2915, 2012. ,
Effect of the PTEN gene on adhesion, invasion and metastasis of osteosarcoma cells, Oncol. Rep, vol.32, pp.1741-1747, 2014. ,
Novel insights into the roles of Rho kinase in cancer, Arch. Immunol. Ther. Exp. (Warsz.), vol.64, pp.259-278, 2016. ,
miR-145 inhibits osteosarcoma cells proliferation and invasion by targeting ROCK1, Tumour Biol, vol.35, pp.7645-7650, 2014. ,
miR-335 suppresses migration and invasion by targeting ROCK1 in osteosarcoma cells, Mol. Cell, Biochem, vol.384, pp.105-111, 2013. ,
Combined microRNA-340 and ROCK1 mRNA profiling predicts tumor progression and prognosis in pediatric osteosarcoma, Int. J. Mol. Sci, vol.15, pp.560-573, 2014. ,
MicroRNA-340 suppresses osteosarcoma tumor growth and metastasis by directly targeting ROCK1, Biochem. Biophys. Res. Commun, vol.437, pp.653-658, 2013. ,
, Biochimica et Biophysica Acta, vol.1861, pp.1009-1023, 2017.
Regulation of chondrocyte differentiation by the actin skeleton and adhesive interactions, J. Cell. Physiol, vol.231, pp.1-8, 2007. ,
Small GTPase protein Rac-1 is activated with maturation and regulates cell morphology and function in chondrocytes, Exp. Cell Res, vol.314, pp.1301-1312, 2008. ,
Rac1/Cdc42 and RhoA GTPases antagonistically regulate chondrocyte proliferation, hypertrophy, and apoptosis, J. Bone Miner. Res, vol.20, pp.1022-1031, 2005. ,
DOI : 10.1359/jbmr.050113
URL : http://onlinelibrary.wiley.com/doi/10.1359/JBMR.050113/pdf
The small GTPase Rho mediates articular chondrocyte phenotype and morphology in response to interleukin-1 alpha and insulin-like growth factor-I, J. Orthop. Res, vol.27, pp.58-64, 2009. ,
DOI : 10.1002/jor.20717
URL : http://onlinelibrary.wiley.com/doi/10.1002/jor.20717/pdf
Rac1 signaling stimulates Ncadherin expression, mesenchymal condensation, and chondrogenesis, J. Biol. Chem, vol.282, pp.23500-23508, 2007. ,
DOI : 10.1074/jbc.m700680200
URL : http://www.jbc.org/content/282/32/23500.full.pdf
Rac1 signaling regulates CTGF/CCN2 gene expression via TGFbeta/Smad signaling in chondrocytes, Osteoarthritis Cartilage, vol.17, pp.406-413, 2009. ,
DOI : 10.1016/j.joca.2008.07.002
URL : https://doi.org/10.1016/j.joca.2008.07.002
Nanomechanics of human adipose-derived stem cells: small GTPases impact chondrogenic differentiation, Tissue Eng. Part A, vol.18, pp.1035-1044, 2012. ,
DOI : 10.1089/ten.tea.2011.0507
MicroRNA-34a modulates cytoskeletal dynamics through regulating RhoA/Rac1 cross-talk in chondroblasts, J. Biol. Chem, vol.287, pp.12501-12509, 2012. ,
DOI : 10.1074/jbc.m111.264382
URL : http://www.jbc.org/content/287/15/12501.full.pdf
Periodic mechanical stress activates integrin?1-dependent Src-dependent PLC?1-independent Rac1 mitogenic signal in rat chondrocytes through ERK1/2, Cell. Physiol. Biochem, vol.30, pp.827-842, 2012. ,
DOI : 10.1159/000341461
Periodic mechanical stress stimulates the FAK mitogenic signal in rat chondrocytes through ERK1/2 activity, Cell. Physiol. Biochem, vol.32, pp.915-930, 2013. ,
DOI : 10.1159/000354495
URL : https://doi.org/10.1159/000354495
Regulation of c hondrocyte proliferation through GIT1-Rac1-mediated ERK1/2 pathway by PDGF, Cell Biol. Int, vol.38, pp.695-701, 2014. ,
DOI : 10.1002/cbin.10241
Genetic ablation of Rac1 in cartilage results in chondrodysplasia, Dev. Biol, vol.306, pp.612-623, 2007. ,
Rac1 mediates loaddriven attenuation of mRNA expression of nerve growth factor beta in cartilage and chondrocytes, J. Musculoskelet. Neuronal Interact, vol.13, pp.372-379, 2013. ,
Knee loading reduces MMP13 activity in the mouse cartilage, BMC Musculoskelet. Disord, vol.14, p.312, 2013. ,
DOI : 10.1186/1471-2474-14-312
URL : http://doi.org/10.1186/1471-2474-14-312
Elucidation of the signaling network of COX-2 induction in sheared chondrocytes: COX-2 is induced via Rac/ MEKK1/MKK7/JNK2/c-Jun-C/EBPbeta-dependent pathway, Am. J. Physiol. Cell Physiol, vol.294, pp.1146-1157, 2008. ,
Inhibition of Rac1 activity by controlled release of NSC23766 from chitosan microspheres effectively ameliorates osteoarthritis development in vivo, Ann. Rheum. Dis, vol.74, pp.285-293, 2015. ,
Rac1 is required for matrix metalloproteinase 13 production by chondrocytes in response to fibronectin fragments, Arthritis Rheum, vol.65, pp.1561-1568, 2013. ,
DOI : 10.1002/art.37922
URL : https://onlinelibrary.wiley.com/doi/pdf/10.1002/art.37922
Ofloxacin induces apoptosis via ?1 integrin-EGFR-Rac1-Nox2 pathway in microencapsulated chondrocytes, Toxicol. Appl. Pharmacol, vol.267, pp.74-87, 2013. ,
DOI : 10.1016/j.taap.2012.12.015
Small GTPases minireviw series, J. Biol. Chem, vol.273, pp.19923-21434, 1992. ,
DOI : 10.1074/jbc.273.32.19923
URL : http://www.jbc.org/content/273/32/19923.full.pdf
Selective activation of the mitogen-activated protein kinase subgroups c-Jun NH 2 terminal kinase and p38 by IL-1 and TNF in human articular chondrocytes, J. Clin. Invest, vol.98, pp.2425-2430, 1996. ,
Biomedical regulation of matrix metalloproteinase-9 in cultured chondrocytes, J. Orthop. Res, vol.18, pp.899-908, 2000. ,
DOI : 10.1002/jor.1100180608
Interleukin-1?,-6, and-8 decrease Cdc42 activity resulting in loss of articular chondrocyte phenotype, J. Orthop. Res, vol.30, pp.246-251, 2012. ,
DOI : 10.1002/jor.21515
URL : http://onlinelibrary.wiley.com/doi/10.1002/jor.21515/pdf
Cdc42 is required for chondrogenesis and interdigital programmed cell death during limb development, Mech. Dev, vol.129, pp.38-50, 2012. ,
Cdc42 is critical for cartilage development during endochondral ossification, Endocrinology, vol.156, pp.314-322, 2015. ,
Insulin-like growth factor-I diminishes the activation status and expression of the small GTPase Cdc42 in articular chondrocytes, J. Orthop. Res, vol.22, pp.436-445, 2004. ,
Signaling through the small G-protein Cdc42 is involved in insulin-like growth factor-I resistance in aging articular chondrocytes, J. Orthop. Res, vol.24, pp.1765-1772, 2006. ,
Skeletal-specific expression of Fgd1 during bone formation and skeletal defects in faciogenital dysplasia (FGDY; Aarskog syndrome), Dev. Dyn, vol.218, pp.573-586, 2000. ,
Altered gene expression in articular chondrocytes of Smad3(ex8/ex8) mice, revealed by gene profiling using microarrays, J. Genet. Genomics, vol.34, pp.698-708, 2007. ,
Rho-ROCK signaling differentially regulates chondrocyte spreading on fibronectin and bone sialoprotein, Am. J. Physiol. Cell Physiol, vol.295, pp.38-49, 2008. ,
RhoA/ROCK signaling suppresses hypertrophic chondrocyte differentiation, J. Biol. Chem, vol.279, pp.13205-13214, 2004. ,
The role of TGF?1 stimulating ROCK I signal pathway to reorganize actin in a rat experimental model of developmental dysplasia of the hip, Mol. Cell. Biochem, vol.391, pp.1-9, 2014. ,
RhoA/ROCK signaling regulates Sox9 expression and actin organization during chondrogenesis, J. Biol. Chem, vol.280, pp.11626-11634, 2005. ,
RhoA/ROCK signaling regulates chondrogenesis in a context-dependent manner, J. Biol. Chem, vol.28, pp.13134-13140, 2006. ,
The transcriptional activity of Sox9 in chondrocytes is regulated by RhoA signaling and actin polymerization, Mol. Cell. Biol, vol.29, pp.4262-4273, 2009. ,
Dynamic compression of chondrocytes induces a Rho kinase-dependent reorganization of the actin cytoskeleton, Biorheology, vol.45, pp.219-228, 2008. ,
Rho kinase-dependent activation of SOX9 in chondrocytes, Arthritis Rheum, vol.62, pp.191-200, 2010. ,
ROCK inhibitor prevents the dedifferentiation of human articular chondrocytes, Biochem. Biophys. Res. Commun, vol.420, pp.124-129, 2012. ,
TGF-alpha and ErbB2 production in synovial joint tissue: increased expression in arthritic joints, Scand. J. Immunol, vol.34, pp.204-211, 2005. ,
Sustained and distinctive patterns of gene activation in synovial fibroblasts and whole synovial tissue obtained from inflammatory synovitis, Scand. J. Immunol, vol.40, pp.292-298, 1994. ,
Rho/ROCK and MEK/ERK activation by transforming growth factor-alpha induces articular cartilage degradation, Lab, pp.20-30, 2010. ,
Cyclic compression-induced p38 activation and subsequent MMP13 expression requires Rho/ROCK activity in bovine cartilage explants, Inflamm. Res, vol.61, pp.1093-1100, 2012. ,
Alleviating effects of AS1892802, a Rho kinase inhibitor, on osteoarthritic disorders in rodents, J. Pharmacol. Sci, vol.115, pp.481-489, 2011. ,
ROCK inhibition enhances aggrecan deposition and suppresses matrix metalloproteinase-3 production in human articular chondrocytes, Connect. Tissue Res, vol.55, pp.89-95, 2014. ,
The effect of ultrasound stimulation on the cytoskeletal organization of chondrocytes seeded in three-dimensional matrices, Cells Tissues Organs, vol.197, pp.14-26, 2013. ,
Leptin-mediated cytoskeletal remodeling in chondrocytes occurs via the RhoA/ROCK pathway, J. Orthop. Res, vol.29, pp.369-374, 2011. ,
Plummer 3rd., Filopodia as sensors, Cell. Signal, vol.25, pp.2298-2311, 2013. ,
Mechanical loading in osteocytes induces formation of a Src/Pyk2/MBD2 complex that suppresses anabolic gene expression, PLoS One, vol.9, p.97942, 2014. ,
Podosome rings generate forces that drive saltatory osteoclast migration, Mol. Biol. Cell, vol.22, pp.3120-3126, 2011. ,
URL : https://hal.archives-ouvertes.fr/hal-00603184
Internal dynamics of actin structures involved in the cell motility and adhesion: modeling of the podosomes at the molecular level, J. Theor. Biol, vol.270, pp.25-30, 2011. ,
URL : https://hal.archives-ouvertes.fr/hal-00536286
Activated c-Fms recruits Vav and Rac during CSF-1-induced cytoskeletal remodeling and spreading in osteoclasts, Bone, vol.39, pp.1290-1301, 2006. ,
Vav3 regulates osteoclast function and bone mass, Nat. Med, vol.11, pp.284-290, 2005. ,
Regulation of osteoclast apoptosis and motility by small GTPase binding protein Rac1, J. Bone Miner. Res, vol.20, pp.2245-2253, 2005. ,
Rac and Cdc42 regulate actin organization and cell adhesion in macrophages, J. Cell Sci, vol.110, pp.707-720, 1997. ,
Identifying the relative contributions of rac1 and rac2 to osteoclastogenesis, J. Bone Miner. Res, vol.23, pp.260-270, 2008. ,
Rac deletion in osteoclasts causes severe osteopetrosis, J. Cell Sci, vol.124, pp.3811-3821, 2011. ,
, Osteoclasts lacking Rac2 have defective chemotaxis and resorptive activity, vol.88, pp.75-86, 2011.
A 3D scanning confocal imaging method measures pit volume and captures the role of Rac in osteoclast function, Bone, vol.51, pp.145-152, 2012. ,
,
, Biochimica et Biophysica Acta, vol.1861, pp.1009-1023, 2017.
, number and a reduced number of osteoblasts in vivo, J. Bone Miner. Res, vol.31, pp.864-873, 2015.
Dock-family exchange factors in cell migration and disease, Eur. J. Cell Biol, vol.93, pp.466-477, 2014. ,
URL : https://hal.archives-ouvertes.fr/hal-01274549
The Rac1 exchange factor Dock5 is essential for bone resorption by osteoclasts, J. Bone Miner. Res, vol.26, pp.1099-1110, 2011. ,
URL : https://hal.archives-ouvertes.fr/hal-00657347
Inhibition of osteoclast bone resorption activity through osteoprotegerin-induced damage of the sealing zone, Int. J. Mol. Med, vol.34, pp.856-862, 2014. ,
RhoV mediates apoptosis of RAW264.7 macrophages caused by osteoclast differentiation, Mol. Med. Rep, vol.11, pp.1153-1159, 2015. ,
, Comparative transcriptomics reveals RhoE as a novel regulator of actin dynamics in bone-resorbing osteoclasts, vol.25, pp.380-396, 2014.
DLC1-dependent parathyroid hormone-like hormone inhibition suppresses breast cancer bone metastasis, J. Clin. Invest, vol.124, pp.1646-1659, 2014. ,
DOI : 10.1172/jci71812
URL : http://www.jci.org/articles/view/71812/files/pdf
Matrix rigidity induces osteolytic gene expression of metastatic breast cancer cells, PLoS One, vol.5, p.15451, 2010. ,
DOI : 10.1371/journal.pone.0015451
URL : https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0015451&type=printable
Inhibition of rho-associated kinase signaling prevents breast cancer metastasis to human bone, Cancer Res, vol.69, pp.8742-8751, 2009. ,
DOI : 10.1158/0008-5472.can-09-1541
URL : http://cancerres.aacrjournals.org/content/canres/69/22/8742.full.pdf
The P2Y13 receptor regulates phosphate metabolism and FGF-23 secretion with effects on skeletal development, FASEB J, vol.28, pp.2249-2259, 2014. ,
DOI : 10.1096/fj.13-243626
URL : http://www.fasebj.org/content/28/5/2249.full.pdf
ECM compliance regulates osteogenesis by influencing MAPK signaling downstream of RhoA and ROCK, J. Bone Miner. Res, vol.24, pp.886-889, 2009. ,
DOI : 10.1359/jbmr.081240
URL : http://onlinelibrary.wiley.com/doi/10.1359/jbmr.081240/pdf
, ABD56 causes osteoclast apoptosis by inhibiting the NF?B and ERK pathways, vol.371, pp.94-98, 2008.
DOI : 10.1016/j.bbrc.2008.04.014
Role of osteoclast extracellular signal-regulated kinase (ERK) in cell survival and maintenance of cell polarity, J. Bone Miner. Res, vol.18, pp.1198-1205, 2003. ,
Mediation of Rac1 activation by kindlin-2: an essential function in osteoblast adhesion, spreading, and proliferation, J. Cell. Biochem, vol.112, pp.2541-2548, 2011. ,
Rac limits TGF-?-induced VEGF synthesis in osteoblasts, Mol. Cell. Endocrinol, vol.405, pp.35-41, 2015. ,
DOI : 10.1016/j.mce.2015.02.002
Rho kinase inhibitors stimulate the migration of human cultured osteoblastic cells by regulating actomyosin activity, Cell. Mol. Biol. Lett, vol.16, pp.279-295, 2011. ,
DOI : 10.2478/s11658-011-0006-z
URL : http://www.degruyter.com/downloadpdf/j/cmble.2011.16.issue-2/s11658-011-0006-z/s11658-011-0006-z.xml
Inhibition of Rac and ROCK signaling influence osteoblast adhesion, differentiation and mineralization on titanium topographies, PLoS One, vol.8, p.58898, 2013. ,
DOI : 10.1371/journal.pone.0058898
URL : https://doi.org/10.1371/journal.pone.0058898
On the role of RhoA/ROCK signaling in contact guidance of bone-forming cells on anisotropic Ti6Al4V surfaces, Acta Biomater, vol.7, pp.1890-1901, 2011. ,
In vitro assays for adhesion and migration of osteoblastic cells (Saos-2) on titanium surfaces, Cell Tissue Res, vol.324, pp.369-375, 2006. ,
Arf GAPs as regulators of the actin cytoskeleton, Biol. Cell, vol.99, pp.583-600, 2007. ,
Biomineralization-an active or passive process?, Connect. Tissue Res, vol.53, pp.438-445, 2012. ,
DOI : 10.3109/03008207.2012.730081
, Biochimica et Biophysica Acta, vol.1861, pp.1009-1023, 2017.