, OR=0.78; p<.05, 1998.

. Falk, Population aged 75 from Gothenburg ADL and IADL 1: Assessment in 1976-77 (n=744) 2: Assessment in, pp.2005-2011, 2014.

C. P. Ferri, M. Prince, C. Brayne, H. Brodaty, L. Fratiglioni et al., Global prevalence of dementia: A Delphi consensus study, Lancet, vol.366, pp.2112-2119, 2005.

R. Brookmeyer, J. E. Ziegler-graham, K. Arrighi, and H. M. , Forecasting the global burden of Alzheimer's disease, Alzheimers Dement, vol.3, pp.186-91, 2007.

A. Lobo, P. Saz, M. G. Dia, J. L. De-la-camara, C. Ventura et al., Prevalence of dementia in a southern European population in two different time periods: The ZARADEMP project, Acta Psychiatr Scand, vol.116, pp.299-307, 2007.

W. A. Rocca, R. C. Petersen, D. S. Knopman, L. E. Hebert, D. A. Evans et al., Trends in the incidence and prevalence of Alzheimer's disease, dementia, and cognitive impairment in the United States, Alzheimers Dement, vol.7, pp.80-93, 2011.

E. M. Schrijvers, B. F. Verhaaren, P. J. Koudstaal, A. Hofman, M. A. Ikram et al., Is dementia incidence declining? Trends in dementia incidence since 1990 in the Rotterdam Study, Neurology, vol.78, pp.1456-63, 2012.

C. Qiu, E. Strauss, L. Winblad, B. Fratiglioni, and L. , Twentyyear changes in dementia occurrence suggest decreasing incidence in central, Neurology, vol.80, pp.1888-94, 2013.

F. E. Matthews, A. Arthur, L. E. Barnes, J. Bond, C. Jagger et al., A two-decade comparison of prevalence of dementia in individuals aged 65 years and older from three geographical areas of England: Results of the Cognitive Function and Ageing Study I and II, Lancet, vol.382, pp.1405-1417, 2013.

K. Christensen, M. Thinggaard, A. Oksuzyan, T. Steenstrup, K. Andersenranberg et al., Physical and cognitive functioning of

L. Grasset, Alzheimer's & Dementia, vol.12, p.279, 2016.

, people older than 90 years: A comparison of two Danish cohorts born 10 years apart, Lancet, vol.382, pp.1507-1520, 2013.

G. Doblhammer, A. Fink, and T. Fritze, Short-term trends in dementia prevalence in Germany between the years, Alzheimers Dement, vol.11, pp.291-300, 2007.

L. E. Hebert, J. L. Bienias, N. T. Aggarwal, R. S. Wilson, D. A. Bennett et al., Change in risk of Alzheimer disease over time, Neurology, vol.75, pp.786-91, 2010.

B. Rorsman, O. Hagnell, and J. Lanke, Prevalence and incidence of senile and multi-infarct dementia in the Lundby Study: A comparison between the time periods, Neuropsychobiology, vol.15, pp.122-131, 1947.

S. Norton, F. E. Matthews, D. E. Barnes, K. Yaffe, and C. Brayne, Potential for primary prevention of Alzheimer's disease: An analysis of populationbased data, Lancet Neurol, vol.13, pp.788-94, 2014.

L. E. Middleton and K. Yaffe, Targets for the prevention of dementia, J Alzheimers Dis, vol.20, pp.915-939, 2010.

C. Qiu, W. Xu, and L. Fratiglioni, Vascular and psychosocial factors in Alzheimer's disease: Epidemiological evidence toward intervention, J Alzheimers Dis, vol.20, pp.689-97, 2010.

R. Sahathevan, A. Brodtmann, and G. A. Donnan, Dementia, stroke, and vascular risk factors: A review, Int J Stroke, vol.7, pp.61-73, 2012.

K. J. Willis and A. M. Hakim, Stroke prevention and cognitive reserve: Emerging approaches to modifying risk and delaying onset of dementia, Front Neurol, vol.4, p.13, 2013.

J. F. Dartigues, M. Gagnon, L. Letenneur, P. Barberger-gateau, D. Commenges et al., Principal lifetime occupation and cognitive impairment in a French elderly cohort (Paquid), Am J Epidemiol, vol.135, pp.981-989, 1992.

. 3c-study-group, Vascular factors and risk of dementia: Design of the Three-City Study and baseline characteristics of the study population, Neuroepidemiology, vol.22, pp.316-341, 2003.

M. Gagnon, L. Letenneur, J. F. Dartigues, D. Commenges, J. M. Orgogozo et al., Validity of the mini-mental state examination as a screening instrument for cognitive impairment and dementia in French elderly community residents, Neuroepidemiology, vol.9, pp.143-50, 1990.

K. Peres, V. Chrysostome, C. Fabrigoule, J. M. Orgogozo, J. F. Dartigues et al., Restriction in complex activities of daily living in MCI: Impact on outcome, Neurology, vol.67, pp.461-467, 2006.

L. Radloff, The CES-D scale: A self-report depression scale for research in the general population, Appl Psychol Meas, vol.1, pp.385-401, 1977.

C. Touraine, C. Helmer, and P. Joly, Predictions in an illness-death model, Stat Methods Med Res, 2013.
DOI : 10.1177/0962280213489234

K. Leffondre, C. Touraine, C. Helmer, and P. Joly, Interval-censored time-toevent and competing risk with death: Is the illness-death model more accurate than the Cox model?, Int J Epidemiol, vol.42, pp.1177-86, 2013.

S. Ukraintseva, F. Sloan, K. Arbeev, and A. Yashin, Increasing rates of dementia at time of declining mortality from stroke, Stroke, vol.37, pp.1155-1164, 2006.

S. Li, F. Yan, G. Li, C. Chen, W. Zhang et al., Is the dementia rate increasing in Beijing? Prevalence and incidence of dementia 10 years later in an urban elderly population, Acta Psychiatr Scand, vol.115, pp.73-82, 2007.

A. Sekita, T. Ninomiya, Y. Tanizaki, Y. Doi, J. Hata et al., Trends in prevalence of Alzheimer's disease and vascular dementia in a Japanese community: The Hisayama Study, Acta Psychiatr Scand, vol.122, pp.319-344, 2010.

K. Y. Chan, W. Wang, J. J. Wu, L. Liu, E. Theodoratou et al., Epidemiology of Alzheimer's disease and other forms of dementia in China, 19902010: A systematic review and analysis, Lancet, vol.381, pp.2016-2039, 2013.

Y. T. Wu, H. Y. Lee, S. Norton, C. Chen, H. Chen et al., Prevalence studies of dementia in mainland China, Hong Kong and Taiwan: A systematic review and meta-analysis, PLoS One, vol.8, p.66252, 2013.

K. Peres, C. Helmer, L. Letenneur, H. Jacqmin-gadda, and P. Barbergergateau, Ten-year change in disability prevalence and related factors in two generations of French elderly community dwellers: Data from the PAQUID study, Aging Clin Exp Res, vol.17, pp.229-264, 2005.

C. Eclipse-collaborative-membersbrayne, P. G. Ince, H. A. Keage, I. G. Mckeith, F. E. Matthews et al., Education, the brain and dementia: Neuroprotection or compensation?, Brain, vol.133, pp.2210-2216, 2010.

I. , Alzheimer's Disease, World Alzheimer Report London, 2015.

F. E. Matthews, A. Arthur, L. E. Barnes, J. Bond, C. Jagger et al., A two-decade comparison of prevalence of dementia in individuals aged 65 years and older from three geographical areas of England: results of the Cognitive Function and Ageing Study I and II, Lancet, vol.382, pp.1405-1417, 2013.

C. Qiu, E. Strauss, L. Bäckman, B. Winblad, and L. Fratiglioni, Twenty-year changes in dementia occurrence suggest decreasing incidence in central, Neurology, vol.80, pp.1888-94, 2013.
DOI : 10.1212/wnl.0b013e318292a2f9

A. Lobo, P. Saz, G. Marcos, J. L. Dia, C. De-la-camara et al., Prevalence of dementia in a southern European population in two different time periods: the ZARADEMP Project, Acta psychiatrica Scandinavica, vol.116, pp.299-307, 2007.

G. Doblhammer, A. Fink, and T. Fritze, Short-term trends in dementia prevalence in Germany between the years, Alzheimers Dement, vol.11, pp.291-300, 2007.
DOI : 10.1016/j.jalz.2014.02.006

E. M. Schrijvers, B. F. Verhaaren, P. J. Koudstaal, A. Hofman, M. A. Ikram et al., Is dementia incidence declining?: Trends in dementia incidence since 1990 in the Rotterdam Study, Neurology, vol.78, pp.1456-63, 2012.

W. A. Rocca, R. C. Petersen, D. S. Knopman, L. E. Hebert, D. A. Evans et al., Trends in the incidence and prevalence of Alzheimer's disease, dementia, and cognitive impairment in the United States, Alzheimers Dement, vol.7, pp.80-93, 2011.

L. Grasset, C. Brayne, P. Joly, H. Jacqmin-gadda, K. Peres et al., Trends in dementia incidence: Evolution over a 10-year period in France, Alzheimer's & Dementia, vol.12, pp.272-80, 2016.

C. L. Satizabal, A. S. Beiser, V. Chouraki, G. Chene, C. Dufouil et al., Incidence of Dementia over Three Decades in the Framingham Heart Study, N Engl J Med, vol.374, pp.523-555, 2016.

H. Jacqmin-gadda, A. Alperovitch, C. Montlahuc, D. Commenges, K. Leffondre et al., 20-Year prevalence projections for dementia and impact of preventive policy about risk factors, European journal of epidemiology, vol.28, pp.493-502, 2013.
DOI : 10.1007/s10654-013-9818-7

S. Norton, F. E. Matthews, D. E. Barnes, K. Yaffe, and C. Brayne, Potential for primary prevention of Alzheimer's disease: an analysis of population-based data, Lancet Neurol, vol.13, pp.788-94, 2014.

H. Amieva, H. Mokri, M. L. Goff, C. Meillon, H. Jacqmin-gadda et al., Compensatory mechanisms in higher-educated subjects with Alzheimer's disease: a study of 20 years of cognitive decline, Brain, vol.137, pp.1167-75, 2014.

J. F. Dartigues, M. Gagnon, L. Letenneur, P. Barberger-gateau, D. Commenges et al., Principal lifetime occupation and cognitive impairment in a French elderly cohort (Paquid), Am J Epidemiol, vol.135, pp.981-989, 1992.

H. Jacqmin-gadda, C. Fabrigoule, D. Commenges, and J. F. Dartigues, A 5-year longitudinal study of the Mini-Mental State Examination in normal aging, Am J Epidemiol, vol.145, pp.498-506, 1997.

M. F. Folstein, S. E. Folstein, and P. R. Mchugh, A practical method for grading the cognitive state of patients for the clinician, J Psychiatr Res, vol.12, pp.189-98, 1975.

B. Isaacs and A. T. Kennie, The Set test as an aid to the detection of dementia in old people, The British journal of psychiatry : the journal of mental science, vol.123, pp.467-70, 1973.

A. Benton, Applications cliniques et expérimentales. Deuxième édition française, 1965.

P. Barberger-gateau, D. Commenges, M. Gagnon, L. Letenneur, C. Sauvel et al., Instrumental activities of daily living as a screening tool for cognitive impairment and dementia in elderly community dwellers, J Am Geriatr Soc, vol.40, pp.1129-1163, 1992.

N. M. Laird and J. H. Ware, Random-effects models for longitudinal data, Biometrics, vol.38, pp.963-74, 1982.

C. Proust-lima, J. F. Dartigues, and H. Jacqmin-gadda, Misuse of the linear mixed model when evaluating risk factors of cognitive decline, Am J Epidemiol, vol.174, pp.1077-88, 2011.
URL : https://hal.archives-ouvertes.fr/inserm-00621015

C. Proust-lima, V. Philipps, and B. Liquet, Estimation of extended mixed models using latent classes and latent processes: the R package lcmm, J Stat Softw, 2016.
URL : https://hal.archives-ouvertes.fr/hal-01759902

M. E. Lenehan, M. J. Summers, N. L. Saunders, J. J. Summers, and J. C. Vickers, Relationship between education and age-related cognitive decline: a review of recent research, Psychogeriatrics, 2014.

T. A. Salthouse, Implications of the Flynn Effect for Age-Cognition Relations, Intelligence, vol.48, pp.51-58, 2015.

V. Skirbekk, M. Stonawski, E. Bonsang, and U. M. Staudinger, The Flynn effect and population aging, Intelligence, vol.41, pp.169-77, 2013.

N. Steiber, Population Aging at Cross-Roads: Diverging Secular Trends in Average Cognitive Functioning and Physical Health in the Older Population of Germany, PloS one, vol.10, p.136583, 2015.

E. M. Zelinski and R. F. Kennison, Not your parents' test scores: cohort reduces psychometric aging effects, Psychol Aging, vol.22, pp.546-57, 2007.

D. Finkel, C. A. Reynolds, J. J. Mcardle, and N. L. Pedersen, Cohort differences in trajectories of cognitive aging. The journals of gerontology Series B, Psychological sciences and social sciences, vol.62, pp.286-94, 2007.

J. De-rotrou, Y. H. Wu, J. B. Mabire, F. Moulin, L. W. De-jong et al., Does cognitive function increase over time in the healthy elderly?, PloS one, vol.8, p.78646, 2013.

S. Sacuiu, D. Gustafson, M. Sjogren, X. Guo, S. Ostling et al., Secular changes in cognitive predictors of dementia and mortality in 70-year-olds, Neurology, vol.75, pp.779-85, 2010.

K. Christensen, M. Thinggaard, A. Oksuzyan, T. Steenstrup, K. Andersen-ranberg et al., Physical and cognitive functioning of people older than 90 years: a comparison of two Danish cohorts born 10 years apart, Lancet, vol.382, pp.1507-1520, 2013.

D. Gerstorf, N. Ram, C. Hoppmann, S. L. Willis, and K. W. Schaie, Cohort differences in cognitive aging and terminal decline in the Seattle Longitudinal Study, Developmental psychology, vol.47, pp.1026-1067, 2011.

A. Brailean, M. Huisman, M. Prince, A. M. Prina, D. J. Deeg et al., Cohort Differences in Cognitive Aging in the Longitudinal Aging Study Amsterdam. The journals of gerontology Series B, Psychological sciences and social sciences, 2016.

N. L. Carret, C. Rainville, N. Lechevallier, S. Lafont, L. Letenneur et al., Influence of education on the benton visual retention test performance as mediated by a strategic search component, Brain and cognition, vol.53, pp.408-419, 2003.

H. Falk, L. Johansson, S. Ostling, K. Thogersen-agerholm, M. Staun et al., Functional disability and ability 75-year-olds: a comparison of two Swedish cohorts born 30 years apart, Age Ageing, vol.43, pp.636-677, 2014.

E. Heikkinen, M. Kauppinen, T. Rantanen, R. Leinonen, T. M. Lyyra et al., Cohort differences in health, functioning and physical activity in the young-old Finnish population, Aging clinical and experimental research, vol.23, pp.126-160, 2011.

K. Pérès, C. Helmer, L. Letenneur, H. Jacqmin-gadda, and P. Barberger-gateau, Ten-year change in disability prevalence and related factors in two generations of French elderly community dwellers: data from the PAQUID study, Aging clinical and experimental research, vol.17, pp.229-264, 2005.

C. Jagger, R. J. Matthews, F. E. Matthews, N. A. Spiers, J. Nickson et al., Cohort differences in disease and disability in the young-old: findings from the MRC Cognitive Function and Ageing Study (MRC-CFAS), BMC public health, vol.7, p.156, 2007.

A. Hofman, W. A. Rocca, C. Brayne, M. M. Breteler, M. Clarke et al., The prevalence of dementia in Europe: a collaborative study of 1980-1990 findings. Eurodem Prevalence Research Group, International journal of epidemiology, vol.20, issue.3, pp.736-784, 1991.

L. J. Launer, K. Andersen, M. E. Dewey, L. Letenneur, A. Ott et al., Rates and risk factors for dementia and Alzheimer's disease: results from EURODEM pooled analyses. EURODEM Incidence Research Group and Work Groups, European Studies of Dementia. Neurology, vol.52, issue.1, pp.78-84, 1999.

C. Brayne, B. C. Stephan, and F. E. Matthews, A European perspective on population studies of dementia, Alzheimers Dement, vol.7, issue.1, pp.3-9, 2011.
DOI : 10.1016/j.jalz.2010.12.003

T. Erkinjuntti, T. Ostbye, R. Steenhuis, and V. Hachinski, The effect of different diagnostic criteria on the prevalence of dementia, N Engl J Med, vol.337, issue.23, pp.1667-74, 1997.

Y. Wu, H. Lee, S. Norton, C. Chen, H. Chen et al., Prevalence studies of dementia in mainland china, Hong Kong and taiwan: a systematic review and meta-analysis, PloS one, vol.8, issue.6, 2013.

C. Qiu, E. Strauss, L. Bäckman, B. Winblad, and L. Fratiglioni, Twenty-year changes in dementia occurrence suggest decreasing incidence in central, Neurology, vol.80, issue.20, pp.1888-94, 2013.

E. Schrijvers, B. Verhaaren, P. J. Koudstaal, A. Hofman, M. A. Ikram et al., Is dementia incidence declining?: Trends in dementia incidence since 1990 in the Rotterdam Study, Neurology, vol.78, pp.1456-63, 2012.

C. L. Satizabal, A. S. Beiser, V. Chouraki, G. Chene, C. Dufouil et al., Incidence of Dementia over Three Decades in the Framingham Heart Study, N Engl J Med, vol.374, issue.6, pp.523-555, 2016.

A. Lobo, P. Saz, M. G. Dia, J. L. De-la-camara, C. Ventura et al., Prevalence of dementia in a southern European population in two different time periods: the ZARADEMP Project, Acta psychiatrica Scandinavica, vol.116, issue.4, pp.299-307, 2007.

W. A. Rocca, R. C. Petersen, D. S. Knopman, L. E. Hebert, D. A. Evans et al., Trends in the incidence and prevalence of Alzheimer's disease, dementia, and cognitive impairment in the United States, Alzheimers Dement, vol.7, issue.1, pp.80-93, 2011.

G. Doblhammer, A. Fink, S. Zylla, and F. Willekens, Compression or expansion of dementia in Germany? An observational study of short-term trends in incidence and death rates of dementia between 2006/07 and 2009/10 based on German health insurance data, vol.7, p.66, 2015.

G. Doblhammer, A. Fink, T. Fritze, E. F. Van-bussel, R. E. Arts et al., Dementia incidence trend over 1992-2014 in the Netherlands: Analysis of primary care data, Alzheimers Dement, vol.11, issue.3, p.1002235, 2007.

K. M. Langa, E. B. Larson, E. M. Crimmins, J. D. Faul, D. A. Levine et al., A Comparison of the Prevalence of Dementia in the United States in 2000 and 2012, JAMA Intern Med, vol.177, issue.1, pp.51-59, 2017.

, Diagnostic and statistical manual of mental disorders, American Psychiatric Association, 2000.

F. E. Matthews, A. Arthur, L. E. Barnes, J. Bond, C. Jagger et al., A two-decade comparison of prevalence of dementia in individuals aged 65 years and older from three geographical areas of England: results of the Cognitive Function and Ageing Study I and II, Lancet, vol.382, issue.9902, pp.1405-1417, 2013.

L. Grasset, C. Brayne, P. Joly, H. Jacqmin-gadda, K. Peres et al., Trends in dementia incidence: Evolution over a 10-year period in France, vol.12, pp.272-80, 2016.

F. E. Matthews, B. C. Stephan, L. Robinson, C. Jagger, L. E. Barnes et al., Will new diagnostic criteria for diabetes mellitus change phenotype of patients with diabetes? Reanalysis of European epidemiological data. DECODE Study Group on behalf of the European Diabetes Epidemiology Study Group, Nature communications, vol.7, issue.7155, pp.371-376, 1998.

J. R. Copeland, M. E. Dewey, and G. Hm, A computerized psychiatric diagnostic system and case nomenclature for elderly subjects: GMS and AGECAT. Psychological medicine, vol.16, pp.89-99, 1986.

J. R. Copeland, M. E. Dewey, and G. Hm, Cognitive function and dementia in six areas of England and Wales: the distribution of MMSE and prevalence of GMS organicity level in the MRC CFA Study. The Medical Research Council Cognitive Function and Ageing Study (MRC CFAS). Psychological medicine, 3C Study Group. Vascular factors and risk of dementia: design of the Three-City Study and baseline characteristics of the study population, vol.5, pp.316-341, 1990.

J. F. Dartigues, M. Gagnon, L. Letenneur, P. Barberger-gateau, D. Commenges et al., Principal lifetime occupation and cognitive impairment in a French elderly cohort (Paquid), Am J Epidemiol, vol.135, issue.9, pp.981-989, 1992.

J. R. Copeland, M. E. Dewey, A. S. Henderson, D. W. Kay, C. D. Neal et al., The Geriatric Mental State (GMS) used in the community: replication studies of the computerized diagnosis AGECAT. Psychological medicine, vol.18, pp.219-242, 1988.

L. J. Launer, Counting dementia: There is no one "best" way, Alzheimers Dement, vol.7, issue.1, pp.10-14, 2011.

T. Grimmer, S. Beringer, V. Kehl, P. Alexopoulos, A. Busche et al., Trends of patient referral to a memory clinic and towards earlier diagnosis from 1985-2009, International psychogeriatrics / IPA, vol.27, issue.12, pp.1939-1983, 2015.

E. Grober and H. Buschke, Genuine memory deficits in dementia, Developmental neuropsychology, vol.3, issue.1, pp.13-36, 1987.

K. Peres, C. Brayne, F. Matharan, L. Grasset, C. Helmer et al., Trends in Prevalence of Dementia in French Farmers from Two Epidemiological Cohorts, J Am Geriatr Soc, vol.65, issue.2, pp.415-435, 2017.

E. M. Crimmins, J. K. Kim, K. M. Langa, and D. R. Weir, Assessment of cognition using surveys and neuropsychological assessment: the Health and Retirement Study and the Aging, Demographics, and Memory Study. The journals of gerontology Series B, Psychological sciences and social sciences, vol.66, pp.162-71, 2011.

K. Pérès, A. Edjolo, J. F. Dartigues, and P. Barberger-gateau, Recent Trends in Disability-Free Life Expectancy in the French Elderly: Twenty Years Follow-Up of the Paquid Cohort, Annual Review of Gerontology and Geriatrics, vol.33, issue.1, pp.293-311, 2013.

C. D. Mathers, G. A. Stevens, T. Boerma, R. A. White, and M. I. Tobias, Causes of international increases in older age life expectancy, Lancet, vol.385, issue.9967, pp.540-548, 2015.

, World Health Organization. World Health Statistics. Geneva, 2014.

V. Kontis, J. E. Bennett, C. D. Mathers, G. Li, K. Foreman et al., Future life expectancy in 35 industrialised countries: projections with a Bayesian model ensemble, Lancet, vol.389, pp.1323-1358, 2017.

, World Alzheimer Report: The Global Impact of Dementia

. London, , 2015.

J. F. Fries, Aging, natural death, and the compression of morbidity, N Engl J Med, vol.303, issue.3, pp.130-135, 1980.

J. Nusselder-wj-;-robine, C. Jagger, C. D. Mathers, E. M. Crimmins, and R. M. Suzman, Determining health expectancies, pp.35-58, 2003.

K. G. Manton, Changing concepts of morbidity and mortality in the elderly population. The Milbank Memorial Fund quarterly Health and society, vol.60, pp.183-244, 1982.

F. E. Matthews, A. Arthur, L. E. Barnes, J. Bond, C. Jagger et al., A two-decade comparison of prevalence of dementia in individuals aged 65 years and older from three geographical areas of England: results of the Cognitive Function and Ageing Study I and II, Lancet, vol.382, issue.9902, pp.1405-1417, 2013.

F. E. Matthews, B. C. Stephan, L. Robinson, C. Jagger, L. E. Barnes et al., A two decade dementia incidence comparison from the Cognitive Function and Ageing Studies I and II, Nature communications, vol.7, p.11398, 2016.

C. Qiu, E. Strauss, L. Bäckman, B. Winblad, and L. Fratiglioni, Twenty-year changes in dementia occurrence suggest decreasing incidence in central, Neurology, vol.80, issue.20, pp.1888-94, 2013.

K. Peres, C. Brayne, F. Matharan, L. Grasset, C. Helmer et al., Trends in Prevalence of Dementia in French Farmers from Two Epidemiological Cohorts, J Am Geriatr Soc, vol.65, issue.2, pp.415-435, 2017.

L. Grasset, C. Brayne, P. Joly, H. Jacqmin-gadda, K. Peres et al., Trends in dementia incidence: Evolution over a 10-year period in France, Alzheimers Dement, vol.12, issue.3, pp.272-80, 2016.

C. L. Satizabal, A. S. Beiser, V. Chouraki, G. Chene, C. Dufouil et al., Incidence of Dementia over Three Decades in the Framingham Heart Study, N Engl J Med, vol.374, issue.6, pp.523-555, 2016.

E. Schrijvers, B. Verhaaren, P. J. Koudstaal, A. Hofman, M. A. Ikram et al., Is dementia incidence declining?: Trends in dementia incidence since 1990 in the Rotterdam Study, Neurology, vol.78, pp.1456-63, 2012.

Y. T. Wu, A. S. Beiser, M. Breteler, L. Fratiglioni, C. Helmer et al., The changing prevalence and incidence of dementia over time-current evidence, Nature reviews Neurology, vol.13, issue.6, pp.327-366, 2017.

A. Wimo, B. M. Sjolund, A. Skoldunger, C. Qiu, I. Klarin et al., Cohort Effects in the Prevalence and Survival of People with Dementia in a Rural Area in Northern Sweden, Journal of Alzheimer's disease : JAD, vol.50, issue.2, pp.387-96, 2016.

G. Doblhammer, A. Fink, S. Zylla, and F. Willekens, Compression or expansion of dementia in Germany? An observational study of short-term trends in incidence and death rates of dementia between 2006/07 and 2009/10 based on German health insurance data, vol.7, p.66, 2015.

J. F. Dartigues, M. Gagnon, L. Letenneur, P. Barberger-gateau, D. Commenges et al., Principal lifetime occupation and cognitive impairment in a French elderly cohort (Paquid), Am J Epidemiol, vol.135, issue.9, pp.981-989, 1992.

. 3c-study-group, Vascular factors and risk of dementia: design of the Three-City Study and baseline characteristics of the study population, Neuroepidemiology, vol.22, issue.6, pp.316-341, 2003.

M. Gagnon, L. Letenneur, J. F. Dartigues, D. Commenges, J. M. Orgogozo et al., Validity of the Mini-Mental State examination as a screening instrument for cognitive impairment and dementia in French elderly community residents, Neuroepidemiology, vol.9, issue.3, pp.143-50, 1990.

K. Pérès, V. Chrysostome, C. Fabrigoule, J. M. Orgogozo, J. F. Dartigues et al., Restriction in complex activities of daily living in MCI: impact on outcome, Neurology, vol.67, issue.3, pp.461-467, 2006.

K. M. Langa, E. B. Larson, J. H. Karlawish, D. M. Cutler, M. U. Kabeto et al., Trends in the prevalence and mortality of cognitive impairment in the United States: is there evidence of a compression of cognitive morbidity?, Alzheimers Dement, vol.4, issue.2, pp.134-178, 2008.

K. Ritchie, J. M. Robine, L. Letenneur, and J. F. Dartigues, Dementia-free life expectancy in France, Am J Public Health, vol.84, issue.2, pp.232-238, 1994.

J. Oeppen, J. W. Vaupel, and . Demography, Broken limits to life expectancy, Science

C. Jagger, F. E. Matthews, P. Wohland, T. Fouweather, B. C. Stephan et al., A comparison of health expectancies over two decades in England: results of the Cognitive Function and Ageing Study I and II, Lancet, vol.387, pp.779-86, 2016.

J. Sagardui-villamor, P. Guallar-castillon, M. Garcia-ferruelo, J. R. Banegas, and F. Rodriguez-artalejo, Trends in disability and disability-free life expectancy among elderly people in Spain: 1986-1999. The journals of gerontology Series A, Biological sciences and medical sciences, vol.60, pp.1028-1062, 2005.

C. Jagger, R. Matthews, F. Matthews, T. Robinson, J. M. Robine et al., The burden of diseases on disability-free life expectancy in later life. The journals of gerontology Series A, Biological sciences and medical sciences, vol.62, pp.408-422, 2007.

E. Cambois, A. Clavel, I. Romieu, and J. M. Robine, Trends in disability-free life expectancy at age 65 in France: consistent and diverging partterns according to the underlying disability measure, Eur J Ageing, vol.5, pp.287-98, 2008.

C. Sauvaget, I. Tsuji, M. N. Haan, and S. Hisamichi, Trends in dementia-free life expectancy among elderly members of a large health maintenance organization, International journal of epidemiology, vol.28, issue.6, pp.1110-1118, 1999.

C. Wolfson, D. B. Wolfson, M. Asgharian, M. Lan, C. E. Ostbye et al., A reevaluation of the duration of survival after the onset of dementia, N Engl J Med, vol.344, issue.15, pp.1111-1117, 2001.

E. B. Larson, M. F. Shadlen, L. Wang, W. C. Mccormick, J. D. Bowen et al., Survival after initial diagnosis of Alzheimer disease, Annals of internal medicine, vol.140, issue.7, pp.501-510, 2004.

C. Jagger, M. Clarke, and A. Stone, Predictors of survival with Alzheimer's disease: a communitybased study, Psychological medicine, vol.25, issue.1, pp.171-178, 1995.

H. Aguero-torres, L. Fratiglioni, Z. Guo, M. Viitanen, and B. Winblad, Prognostic factors in very old demented adults: a seven-year follow-up from a population-based survey in Stockholm, J Am Geriatr Soc, vol.46, issue.4, pp.444-52, 1998.

P. T. Van-dijk, D. W. Dippel, and J. D. Habbema, Survival of patients with dementia, J Am Geriatr Soc, vol.39, issue.6, pp.603-613, 1991.

A. L. Fitzpatrick, L. H. Kuller, O. L. Lopez, C. H. Kawas, and W. Jagust,

, Alzheimer's disease and vascular dementia, Journal of the neurological sciences, vol.229, issue.230, pp.43-52, 2005.

S. Todd, S. Barr, M. Roberts, and A. P. Passmore, Survival in dementia and predictors of mortality: a review, International journal of geriatric psychiatry, vol.28, issue.11, pp.1109-1133, 2013.

Y. Stern, M. X. Tang, M. S. Albert, J. Brandt, D. M. Jacobs et al., Predicting time to nursing home care and death in individuals with Alzheimer disease, JAMA, vol.277, issue.10, pp.806-818, 1997.

M. F. Dubois and R. Hebert, Cognitive-impairment-free life expectancy for Canadian seniors

, Dement Geriatr Cogn Disord, vol.22, issue.4, pp.327-360, 2006.

I. Contador, Y. Stern, F. Bermejo-pareja, A. Sanchez-ferro, and J. Benito-leon, Is Educational Attainment Associated with Increased Risk of Mortality in People with Dementia? A Population-based Study, Current Alzheimer research, vol.14, issue.5, pp.571-577, 2017.

X. Meng, D. &apos;arcy, and C. , Education and dementia in the context of the cognitive reserve hypothesis: a systematic review with meta-analyses and qualitative analyses, PloS one, vol.7, issue.6, p.38268, 2012.

S. E. Tom, R. A. Hubbard, P. K. Crane, S. J. Haneuse, J. Bowen et al., Characterization of dementia and Alzheimer's disease in an older population: updated incidence and life expectancy with and without dementia, Am J Public Health, vol.105, issue.2, pp.408-421, 2015.

M. Reuser, F. J. Willekens, and L. Bonneux, Higher education delays and shortens cognitive impairment: a multistate life table analysis of the US Health and Retirement Study, European journal of epidemiology, vol.26, issue.5, pp.395-403, 2011.
URL : https://hal.archives-ouvertes.fr/hal-00671935

A. Lievre, D. Alley, and E. M. Crimmins, 9-12.0) 71.2 (68.5-75.0) 32.5 (26.1-34.6) 13.1 (10.2-14.9) 54.4 (52.2-62.8) p00: Probability of being alive without dementia; p01: Probability of being alive with dementia, J Aging Health, vol.20, issue.4, pp.456-77, 2008.

, World Health Organisation. Life expectancy, 2017.

C. D. Mathers, G. A. Stevens, T. Boerma, R. A. White, and M. I. Tobias, Causes of international increases in older age life expectancy, Lancet, vol.385, issue.9967, pp.540-548, 2015.

. Insee, Tableaux de l'économie françaiseInsee, pp.978-980, 2016.

V. Kontis, J. E. Bennett, C. D. Mathers, G. Li, K. Foreman et al., Future life expectancy in 35 industrialised countries: projections with a Bayesian model ensemble, Lancet, vol.389, pp.1323-1358, 2017.

D. Blanchet, L. Gallo, and F. , Baby-boom et allongement de la durée de vie : quelles contributions au vieillissement ? : Insee, 2013.

, World Alzheimer Report: The Global Impact of Dementia

. London, , 2015.

O. , Panorama de la santé 2013 : Les indicateurs de l'OCDE. OCDE, 2013.

N. Blanpain and O. Chardon, Projection de population à l'horizon 2060, 2010.

M. J. Prince, F. Wu, Y. Guo, G. Robledo, L. M. et al., The burden of disease in older people and implications for health policy and practice, Lancet, vol.385, issue.9967, pp.549-62, 2015.

C. Helmer, K. Peres, L. Letenneur, L. M. Guttierez-robledo, H. Ramaroson et al., Dementia in subjects aged 75 years or over within the PAQUID cohort: prevalence and burden by severity, Dement Geriatr Cogn Disord, vol.22, issue.1, pp.87-94, 2006.

, Alzheimer's Disease International. Dementia: A public health priority. Geneva. World Health Organization, World Health Organisation, 2012.

R. Schulz and S. R. Beach, Caregiving as a risk factor for mortality: the Caregiver Health Effects Study, JAMA, vol.282, issue.23, pp.2215-2224, 1999.

R. Schulz, A. T. O&apos;brien, J. Bookwala, and K. Fleissner, Psychiatric and physical morbidity effects of dementia caregiving: prevalence, correlates, and causes, The Gerontologist, vol.35, issue.6, pp.771-91, 1995.

C. Helmer, K. Pérès, A. Pariente, F. Pasquier, S. Auriacombe et al., Primary and secondary care consultations in elderly demented individuals in France. Results from the Three-City Study, Dement Geriatr Cogn Disord, vol.26, issue.5, pp.407-422, 2008.

C. Pimouguet, F. Delva, L. Goff, M. Stern, Y. Pasquier et al., Survival and early recourse to care for dementia: A population based study, Alzheimers Dement, vol.11, issue.4, pp.385-93, 2015.

R. C. Petersen, Mild cognitive impairment as a diagnostic entity, J Intern Med, vol.256, issue.3, pp.183-94, 2004.

K. M. Langa, N. L. Foster, and E. B. Larson, Mixed dementia: emerging concepts and therapeutic implications, JAMA, vol.292, issue.23, pp.2901-2909, 2004.

D. A. Bennett, Mixed pathologies and neural reserve: Implications of complexity for Alzheimer disease drug discovery, PLoS medicine, vol.14, issue.3, p.1002256, 2017.

T. Mura, J. F. Dartigues, and C. Berr, How many dementia cases in France and Europe? Alternative projections and scenarios 2010-2050, European journal of neurology, vol.17, issue.2, pp.252-261, 2010.
URL : https://hal.archives-ouvertes.fr/inserm-00426844

L. Fratiglioni, L. J. Launer, K. Andersen, M. M. Breteler, J. R. Copeland et al., Incidence of dementia and major subtypes in Europe: A collaborative study of population-based cohorts. Neurologic Diseases in the Elderly Research Group, Neurology, vol.54, issue.11, pp.10-15, 2000.

C. Gallez, Rapport sur la maladie d'Alzheimer et les maladies apparentées.Assemblée nationale/Sénat, 2005.

, Alzheimer's Disease Anti-inflammatory Prevention Trial Research G. Results of a follow-up study to the randomized Alzheimer's Disease Anti-inflammatory Prevention Trial (ADAPT), Alzheimers Dement, vol.9, issue.6, pp.714-737, 2013.

M. Luppa, T. Luck, S. Weyerer, H. H. Konig, E. Brahler et al., Prediction of institutionalization in the elderly. A systematic review, Age Ageing, vol.39, issue.1, pp.31-39, 2010.

A. Hajek, C. Brettschneider, C. Lange, T. Posselt, B. Wiese et al., Longitudinal Predictors of Institutionalization in Old Age, PloS one, vol.10, issue.12, p.144203, 2015.

L. Fratiglioni, Y. Forsell, A. Torres, H. Winblad, and B. , Severity of dementia and institutionalization in the elderly: prevalence data from an urban area in Sweden, Neuroepidemiology, vol.13, issue.3, pp.79-88, 1994.

M. Luppa, T. Luck, E. Brahler, H. H. Konig, and S. G. Riedel-heller, Prediction of institutionalisation in dementia. A systematic review, Dement Geriatr Cogn Disord, vol.26, issue.1, pp.65-78, 2008.

T. Luck, M. Luppa, S. Weber, H. Matschinger, H. Glaesmer et al., Time until institutionalization in incident dementia cases-results of the Leipzig Longitudinal Study of the Aged (LEILA 75+), Neuroepidemiology, vol.31, issue.2, pp.100-108, 2008.

A. Wimo, M. Guerchet, G. C. Ali, Y. T. Wu, A. M. Prina et al., The worldwide costs of dementia 2015 and comparisons with 2010, Alzheimers Dement, vol.13, issue.1, pp.1-7, 2017.

H. Aguero-torres, L. Fratiglioni, Z. Guo, M. Viitanen, and B. Winblad, Mortality from dementia in advanced age: a 5-year follow-up study of incident dementia cases, Journal of clinical epidemiology, vol.52, issue.8, pp.737-780, 1999.

C. Helmer, P. Joly, L. Letenneur, D. Commenges, and J. F. Dartigues, Mortality with dementia: results from a French prospective community-based cohort, Am J Epidemiol, vol.154, issue.7, pp.642-650, 2001.

C. Jagger, K. Andersen, M. M. Breteler, J. R. Copeland, C. Helmer et al., Prognosis with dementia in Europe: A collaborative study of population-based cohorts. Neurologic Diseases in the Elderly Research Group, Neurology, vol.54, issue.11, pp.16-20, 2000.

C. Wolfson, D. B. Wolfson, M. Asgharian, M. Lan, C. E. Ostbye et al., A reevaluation of the duration of survival after the onset of dementia, N Engl J Med, vol.344, issue.15, pp.1111-1117, 2001.

E. B. Larson, M. F. Shadlen, L. Wang, W. C. Mccormick, J. D. Bowen et al., Survival after initial diagnosis of Alzheimer disease, Annals of internal medicine, vol.140, issue.7, pp.501-510, 2004.

S. Todd, S. Barr, M. Roberts, and A. P. Passmore, Survival in dementia and predictors of mortality: a review, International journal of geriatric psychiatry, vol.28, issue.11, pp.1109-1133, 2013.
DOI : 10.1002/gps.3946

A. L. Fitzpatrick, L. H. Kuller, O. L. Lopez, C. H. Kawas, and W. Jagust,

, Alzheimer's disease and vascular dementia, Journal of the neurological sciences, vol.229, issue.230, pp.43-52, 2005.

K. Ritchie, C. Mathers, and A. Jorm, Dementia-free life expectancy in Australia. Australian journal of public health, vol.18, pp.149-52, 1994.

K. Ritchie, J. M. Robine, L. Letenneur, and J. F. Dartigues, Dementia-free life expectancy in France, Am J Public Health, vol.84, issue.2, pp.232-238, 1994.

C. Sauvaget, I. Tsuji, Y. Minami, A. Fukao, S. Hisamichi et al., Dementia-free life expectancy among elderly Japanese, Gerontology, vol.43, issue.3, pp.168-75, 1997.

S. E. Tom, R. A. Hubbard, P. K. Crane, S. J. Haneuse, J. Bowen et al., Characterization of dementia and Alzheimer's disease in an older population: updated incidence and life expectancy with and without dementia, Am J Public Health, vol.105, issue.2, pp.408-421, 2015.

D. Rizzuto, N. Orsini, C. Qiu, H. X. Wang, and L. Fratiglioni, Lifestyle, social factors, and survival after age 75: population based study, Bmj, vol.345, p.5568, 2012.

H. Brodaty, K. Seeher, and L. Gibson, Dementia time to death: a systematic literature review on survival time and years of life lost in people with dementia, International psychogeriatrics / IPA, vol.24, issue.7, pp.1034-1079, 2012.

B. Winblad, P. Amouyel, S. Andrieu, C. Ballard, C. Brayne et al., Defeating Alzheimer's disease and other dementias: a priority for European science and society, Lancet Neurol, vol.15, issue.5, pp.455-532, 2016.

C. P. Ferri, M. Prince, C. Brayne, H. Brodaty, L. Fratiglioni et al., Global prevalence of dementia: a Delphi consensus study, Lancet, vol.366, issue.9503, pp.2112-2119, 2005.

L. E. Hebert, J. Weuve, P. A. Scherr, and D. A. Evans, Alzheimer disease in the United States (2010-2050) estimated using the 2010 census, Neurology, vol.80, pp.1778-83, 2013.

F. E. Matthews, B. C. Stephan, L. Robinson, C. Jagger, L. E. Barnes et al., A two decade dementia incidence comparison from the Cognitive Function and Ageing Studies I and II, Nature communications, vol.7, p.11398, 2016.

W. J. Strittmatter, A. M. Saunders, D. Schmechel, M. Pericak-vance, J. Enghild et al.,

, Apolipoprotein E: high-avidity binding to beta-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease, Proceedings of the National Academy of Sciences of the United States of America, vol.90, issue.5, pp.1977-81, 1993.

E. H. Corder, A. M. Saunders, W. J. Strittmatter, D. E. Schmechel, P. C. Gaskell et al., Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families, Science, vol.261, issue.5123, pp.921-924, 1993.

L. A. Farrer, L. A. Cupples, J. L. Haines, B. Hyman, W. A. Kukull et al., Effects of age, sex, and ethnicity on the association between apolipoprotein E genotype and Alzheimer disease. A metaanalysis. APOE and Alzheimer Disease Meta Analysis Consortium, JAMA, vol.278, issue.16, pp.1349-56, 1997.

M. C. Chartier-harlin, M. Parfitt, S. Legrain, J. Perez-tur, T. Brousseau et al.,

E. Apolipoprotein, epsilon 4 allele as a major risk factor for sporadic early and late-onset forms of Alzheimer's disease: analysis of the 19q13.2 chromosomal region, Human molecular genetics, vol.3, issue.4, pp.569-74, 1994.

C. Ballard, S. Gauthier, A. Corbett, C. Brayne, D. Aarsland et al., Alzheimer's disease, Lancet, vol.377, issue.9770, pp.1019-1050, 2011.

J. C. Lambert, C. A. Ibrahim-verbaas, D. Harold, A. C. Naj, R. Sims et al., Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease, Nature genetics, vol.45, issue.12, pp.1452-1460, 2013.

J. Hardy, A. Myers, and F. Wavrant-de-vrieze, Problems and solutions in the genetic analysis of lateonset Alzheimer's disease. Neuro-degenerative diseases, vol.1, pp.213-220, 2004.

Y. Stern, B. Gurland, T. K. Tatemichi, M. X. Tang, D. Wilder et al., Influence of education and occupation on the incidence of Alzheimer's disease, JAMA, vol.271, issue.13, pp.1004-1014, 1994.

L. Letenneur, V. Gilleron, D. Commenges, C. Helmer, J. M. Orgogozo et al., Are sex and educational level independent predictors of dementia and Alzheimer's disease? Incidence data from the PAQUID project, Journal of neurology, vol.66, issue.2, pp.177-83, 1999.

E. Members, C. Brayne, P. G. Ince, H. Keage, I. G. Mckeith et al., Education, the brain and dementia: neuroprotection or compensation?, Brain, vol.133, pp.2210-2216, 2010.

X. Meng, D. &apos;arcy, and C. , Education and dementia in the context of the cognitive reserve hypothesis: a systematic review with meta-analyses and qualitative analyses, PloS one, vol.7, issue.6, p.38268, 2012.

J. F. Dartigues, M. Gagnon, L. Letenneur, P. Barberger-gateau, D. Commenges et al., Principal lifetime occupation and cognitive impairment in a French elderly cohort (Paquid), Am J Epidemiol, vol.135, issue.9, pp.981-989, 1992.
DOI : 10.1093/oxfordjournals.aje.a116410

A. Foubert-samier, G. Catheline, H. Amieva, B. Dilharreguy, C. Helmer et al., Education, occupation, leisure activities, and brain reserve: a population-based study, Neurobiology of aging, vol.33, issue.2, pp.423-438, 2012.
DOI : 10.1016/j.neurobiolaging.2010.09.023

L. A. Yates, S. Ziser, A. Spector, and M. Orrell, Cognitive leisure activities and future risk of cognitive impairment and dementia: systematic review and meta-analysis, International psychogeriatrics / IPA, vol.28, issue.11, pp.1791-806, 2016.

Y. Stern, What is cognitive reserve? Theory and research application of the reserve concept, J Int Neuropsychol Soc, vol.8, issue.3, pp.448-60, 2002.

M. J. Valenzuela, Brain reserve and the prevention of dementia. Current opinion in psychiatry, vol.21, pp.296-302, 2008.

R. P. Kloppenborg, E. Van-den-berg, L. J. Kappelle, and G. J. Biessels, Diabetes and other vascular risk factors for dementia: which factor matters most? A systematic review, European journal of pharmacology, vol.585, issue.1, pp.97-108, 2008.

D. E. Barnes and K. Yaffe, The projected effect of risk factor reduction on Alzheimer's disease prevalence, Lancet Neurol, vol.10, issue.9, pp.819-847, 2011.

A. Hofman, A. Ott, M. M. Breteler, M. L. Bots, A. J. Slooter et al., Atherosclerosis, apolipoprotein E, and prevalence of dementia and Alzheimer's disease in the Rotterdam Study, Lancet, vol.349, issue.9046, pp.151-155, 1997.

L. J. Launer, G. W. Ross, H. Petrovitch, K. Masaki, D. Foley et al., Midlife blood pressure and dementia: the Honolulu-Asia aging study, Neurobiology of aging, vol.21, issue.1, pp.49-55, 2000.

M. Kivipelto, E. L. Helkala, M. P. Laakso, T. Hanninen, M. Hallikainen et al., Midlife vascular risk factors and Alzheimer's disease in later life: longitudinal, population based study, Bmj, vol.322, issue.7300, pp.1447-51, 2001.
DOI : 10.1136/bmj.322.7300.1447

URL : http://www.bmj.com/content/bmj/322/7300/1447.full.pdf

M. Kivipelto, E. L. Helkala, T. Hanninen, M. P. Laakso, M. Hallikainen et al., Midlife vascular risk factors and late-life mild cognitive impairment: A population-based study, Neurology, vol.56, issue.12, pp.1683-1692, 2001.
DOI : 10.1212/wnl.56.12.1683

C. Qiu, B. Winblad, and L. Fratiglioni, The age-dependent relation of blood pressure to cognitive function and dementia, Lancet Neurol, vol.4, issue.8, pp.487-99, 2005.
DOI : 10.1016/s1474-4422(05)70141-1

R. A. Whitmer, S. Sidney, J. Selby, S. C. Johnston, and K. Yaffe, Midlife cardiovascular risk factors and risk of dementia in late life, Neurology, vol.64, issue.2, pp.277-81, 2005.

S. P. Kennelly, B. A. Lawlor, and R. A. Kenny, Blood pressure and dementia-a comprehensive review
DOI : 10.1177/1756285609103483

URL : http://journals.sagepub.com/doi/pdf/10.1177/1756285609103483

E. Van-den-berg, R. P. Kloppenborg, R. P. Kessels, L. J. Kappelle, and G. J. Biessels, Type 2 diabetes mellitus, hypertension, dyslipidemia and obesity: A systematic comparison of their impact on cognition, Biochimica et biophysica acta, vol.2, issue.4, pp.470-81, 2009.
URL : https://hal.archives-ouvertes.fr/hal-00501592

S. E. Vermeer, N. D. Prins, T. Den-heijer, A. Hofman, P. J. Koudstaal et al., Silent brain infarcts and the risk of dementia and cognitive decline, N Engl J Med, vol.348, issue.13, pp.1215-1237, 2003.

D. A. Snowdon, L. H. Greiner, J. A. Mortimer, K. P. Riley, P. A. Greiner et al., Brain infarction and the clinical expression of Alzheimer disease. The Nun Study, JAMA, vol.277, issue.10, pp.813-820, 1997.

M. Kivipelto, E. L. Helkala, M. P. Laakso, T. Hanninen, M. Hallikainen et al.,

, elevated midlife total cholesterol level, and high midlife systolic blood pressure are independent risk factors for late-life Alzheimer disease, Annals of internal medicine, vol.137, issue.3, pp.149-55, 2002.

M. Kivipelto and A. Solomon, Cholesterol as a risk factor for Alzheimer's disease-epidemiological evidence, Acta Neurol Scand Suppl, vol.185, pp.50-57, 2006.

K. J. Anstey, D. M. Lipnicki, and L. F. Low, Cholesterol as a risk factor for dementia and cognitive decline: a systematic review of prospective studies with meta-analysis. The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry, vol.16, pp.343-54, 2008.

C. Reitz, M. X. Tang, J. Luchsinger, and R. Mayeux, Relation of plasma lipids to Alzheimer disease and vascular dementia, Arch Neurol, vol.61, issue.5, pp.705-719, 2004.

M. M. Mielke, P. P. Zandi, M. Sjogren, D. Gustafson, S. Ostling et al., High total cholesterol levels in late life associated with a reduced risk of dementia, Neurology, vol.64, issue.10, pp.1689-95, 2005.

R. Stewart, L. R. White, Q. L. Xue, and L. J. Launer, Twenty-six-year change in total cholesterol levels and incident dementia: the Honolulu-Asia Aging Study, Arch Neurol, vol.64, issue.1, pp.103-110, 2007.

F. P. Lu, K. P. Lin, and H. K. Kuo, Diabetes and the risk of multi-system aging phenotypes: a systematic review and meta-analysis, PloS one, vol.4, issue.1, p.4144, 2009.

L. A. Profenno, A. P. Porsteinsson, and S. V. Faraone, Meta-analysis of Alzheimer's disease risk with obesity, diabetes, and related disorders, Biological psychiatry, vol.67, issue.6, pp.505-517, 2010.

G. Cheng, C. Huang, H. Deng, and H. Wang, Diabetes as a risk factor for dementia and mild cognitive impairment: a meta-analysis of longitudinal studies, Internal medicine journal, vol.42, issue.5, pp.484-91, 2012.

G. J. Biessels, S. Staekenborg, E. Brunner, C. Brayne, and P. Scheltens, Risk of dementia in diabetes mellitus: a systematic review, Lancet Neurol, vol.5, issue.1, pp.64-74, 2006.

K. Yaffe, T. Blackwell, A. M. Kanaya, N. Davidowitz, E. Barrett-connor et al., Diabetes, impaired fasting glucose, and development of cognitive impairment in older women, Neurology, vol.63, issue.4, pp.658-63, 2004.

M. A. Beydoun, H. A. Beydoun, and Y. Wang, Obesity and central obesity as risk factors for incident dementia and its subtypes: a systematic review and meta-analysis. Obesity reviews : an official journal of the International Association for the Study of Obesity, vol.9, pp.204-222, 2008.

T. L. Emmerzaal, A. J. Kiliaan, and D. R. Gustafson, 2003-2013: a decade of body mass index, Journal of Alzheimer's disease : JAD, vol.43, issue.3, pp.739-55, 2015.

M. Loef and H. Walach, Midlife obesity and dementia: meta-analysis and adjusted forecast of dementia prevalence in the United States and China, Obesity (Silver Spring, Md), vol.21, issue.1, pp.51-56, 2013.

A. L. Fitzpatrick, L. H. Kuller, O. L. Lopez, P. Diehr, O. Meara et al., Midlife and late-life obesity and the risk of dementia: cardiovascular health study, Arch Neurol, vol.66, issue.3, pp.336-378, 2009.

J. A. Luchsinger and D. R. Gustafson, Adiposity and Alzheimer's disease. Current opinion in clinical nutrition and metabolic care, vol.12, pp.15-21, 2009.

K. Yaffe, A. Kanaya, K. Lindquist, E. M. Simonsick, T. Harris et al., The metabolic syndrome, inflammation, and risk of cognitive decline, JAMA, vol.292, issue.18, pp.2237-2279, 2004.

D. E. Barnes, T. J. Haight, K. M. Mehta, M. C. Carlson, L. H. Kuller et al., Secondhand smoke, vascular disease, and dementia incidence: findings from the cardiovascular health cognition study, Am J Epidemiol, vol.171, issue.3, pp.292-302, 2010.
DOI : 10.1093/aje/kwp376

URL : https://academic.oup.com/aje/article-pdf/171/3/292/403565/kwp376.pdf

R. Chen, Z. Hu, D. Zhang, Y. Ma, and L. Wei, Second-hand smoke and dementia, Epidemiology, vol.24, issue.4, pp.623-627, 2013.
DOI : 10.1097/ede.0b013e31829658f6

URL : http://pdfs.journals.lww.com/epidem/2013/07000/Second_Hand_Smoke_and_Dementia.24.pdf?token=method|ExpireAbsolute;source|Journals;ttl|1505245582609;payload|mY8D3u1TCCsNvP5E421JYK6N6XICDamxByyYpaNzk7FKjTaa1Yz22MivkHZqjGP4kdS2v0J76WGAnHACH69s21Csk0OpQi3YbjEMdSoz2UhVybFqQxA7lKwSUlA502zQZr96TQRwhVlocEp/sJ586aVbcBFlltKNKo+tbuMfL73hiPqJliudqs17cHeLcLbV/CqjlP3IO0jGHlHQtJWcICDdAyGJMnpi6RlbEJaRheGeh5z5uvqz3FLHgPKVXJzd5TRmh5ELJGgVnzin1EtA2BET/8Odbqi+YADw4+EdjRM=;hash|fzqwR7/32HhzgteE4ZvQnQ==

K. J. Anstey, C. Von-sanden, A. Salim, and R. O&apos;kearney, Smoking as a risk factor for dementia and cognitive decline: a meta-analysis of prospective studies, Am J Epidemiol, vol.166, issue.4, pp.367-78, 2007.

G. E. Swan and C. N. Lessov-schlaggar, The effects of tobacco smoke and nicotine on cognition and the brain, Neuropsychology review, vol.17, issue.3, pp.259-73, 2007.

Y. Rolland, A. Van-kan, G. Vellas, and B. , Physical activity and Alzheimer's disease: from prevention to therapeutic perspectives, Journal of the American Medical Directors Association, vol.9, issue.6, pp.390-405, 2008.
DOI : 10.1016/j.jamda.2008.02.007

URL : http://www.udel.edu/PT/PT Clinical Services/journalclub/noajc/08_09/Nov08/Physical Activity and Alzheimer's disease.pdf

M. Hamer and Y. Chida, Physical activity and risk of neurodegenerative disease: a systematic review of prospective evidence, Psychological medicine, vol.39, issue.1, pp.3-11, 2009.

R. F. De-bruijn, E. M. Schrijvers, K. A. De-groot, J. C. Witteman, A. Hofman et al., The association between physical activity and dementia in an elderly population: the Rotterdam Study, European journal of epidemiology, vol.28, issue.3, pp.277-83, 2013.

S. J. Blondell, R. Hammersley-mather, and J. L. Veerman, Does physical activity prevent cognitive decline and dementia?: A systematic review and meta-analysis of longitudinal studies, BMC public health, vol.14, p.510, 2014.

L. Grasset, P. Joly, H. Jacqmin-gadda, L. Letenneur, J. Wittwer et al., Real benefit of a protective factor against dementia: Importance of controlling for death. Example of sport practice, PloS one, vol.12, issue.4, p.174950, 2017.

C. Samieri, F. Grodstein, B. A. Rosner, J. H. Kang, N. R. Cook et al., Mediterranean diet and cognitive function in older age, Epidemiology, vol.24, issue.4, pp.490-499, 2013.

M. C. Morris, C. C. Tangney, Y. Wang, F. M. Sacks, L. L. Barnes et al., MIND diet slows cognitive decline with aging, Alzheimers Dement, vol.11, issue.9, pp.1015-1037, 2015.

M. C. Morris, C. C. Tangney, Y. Wang, F. M. Sacks, D. A. Bennett et al., MIND diet associated with reduced incidence of Alzheimer's disease, Alzheimers Dement, vol.11, issue.9, pp.1007-1021, 2015.

N. Scarmeas, Y. Stern, R. Mayeux, and J. A. Luchsinger, Alzheimer disease, and vascular mediation, Arch Neurol, vol.63, issue.12, pp.1709-1726, 2006.

N. Scarmeas, Y. Stern, M. X. Tang, R. Mayeux, and J. A. Luchsinger, Mediterranean diet and risk for Alzheimer's disease, Annals of neurology, vol.59, issue.6, pp.912-933, 2006.

F. Sofi, R. Abbate, G. F. Gensini, and A. Casini, Accruing evidence on benefits of adherence to the Mediterranean diet on health: an updated systematic review and meta-analysis. The American journal of clinical nutrition, vol.92, pp.1189-96, 2010.

C. Dufouil, R. Fuhrer, J. F. Dartigues, and A. Alperovitch, Longitudinal analysis of the association between depressive symptomatology and cognitive deterioration, Am J Epidemiol, vol.144, issue.7, pp.634-675, 1996.

P. Chen, M. Ganguli, B. H. Mulsant, and S. T. Dekosky, The temporal relationship between depressive symptoms and dementia: a community-based prospective study. Archives of general psychiatry, vol.56, pp.261-267, 1999.

R. Heun, M. Kockler, and U. Ptok, Depression in Alzheimer's disease: is there a temporal relationship between the onset of depression and the onset of dementia? European psychiatry : the journal of the Association of European Psychiatrists, vol.17, pp.254-262, 2002.

M. Ganguli, Y. Du, H. H. Dodge, G. G. Ratcliff, and C. C. Chang, Depressive symptoms and cognitive decline in late life: a prospective epidemiological study. Archives of general psychiatry, vol.63, pp.153-60, 2006.

R. S. Wilson, G. M. Hoganson, K. B. Rajan, L. L. Barnes, C. F. Mendes-de-leon et al., Temporal course of depressive symptoms during the development of Alzheimer disease, Neurology, vol.75, issue.1, pp.21-27, 2010.

R. S. Wilson, L. L. Barnes, C. F. Mendes-de-leon, N. T. Aggarwal, J. S. Schneider et al., Depressive symptoms, cognitive decline, and risk of AD in older persons, Neurology, vol.59, issue.3, pp.364-70, 2002.

D. E. Barnes, K. Yaffe, A. L. Byers, M. Mccormick, C. Schaefer et al., Midlife vs late-life depressive symptoms and risk of dementia: differential effects for Alzheimer disease and vascular dementia. Archives of general psychiatry, vol.69, pp.493-501, 2012.

B. S. Diniz, M. A. Butters, S. M. Albert, M. A. Dew, and C. F. Reynolds, Late-life depression and risk of vascular dementia and Alzheimer's disease: systematic review and meta-analysis of communitybased cohort studies. The British journal of psychiatry : the journal of mental science, vol.3, pp.329-364, 2013.

G. S. Alexopoulos, Vascular disease, depression, and dementia, J Am Geriatr Soc, vol.51, issue.8, pp.1178-80, 2003.

L. Letenneur, K. Peres, H. Fleury, I. Garrigue, P. Barberger-gateau et al., Seropositivity to herpes simplex virus antibodies and risk of Alzheimer's disease: a population-based cohort study, PloS one, vol.3, issue.11, p.3637, 2008.

R. Baudron, C. Letenneur, L. Langlais, A. Buissonniere, A. Megraud et al.,

, Does Helicobacter pylori infection increase incidence of dementia? The Personnes Agees QUID Study, J Am Geriatr Soc, vol.61, issue.1, pp.74-82, 2013.

H. Lovheim, J. Gilthorpe, A. Johansson, S. Eriksson, G. Hallmans et al., Herpes simplex infection and the risk of Alzheimer's disease: A nested case-control study, Alzheimers Dement, vol.11, issue.6, pp.587-92, 2015.

C. B. Wright, H. Gardener, C. Dong, M. Yoshita, C. Decarli et al., Infectious Burden and Cognitive Decline in the Northern Manhattan Study, J Am Geriatr Soc, vol.63, issue.8, pp.1540-1545, 2015.

H. Lovheim, F. Elgh, A. Johansson, H. Zetterberg, K. Blennow et al., Plasma concentrations of free amyloid beta cannot predict the development of Alzheimer's disease. Alzheimers Dement, 2017.

I. Baldi, P. Lebailly, B. Mohammed-brahim, L. Letenneur, J. F. Dartigues et al., Neurodegenerative diseases and exposure to pesticides in the elderly, Am J Epidemiol, vol.157, issue.5, pp.409-423, 2003.

V. Rondeau, H. Jacqmin-gadda, D. Commenges, C. Helmer, and J. F. Dartigues, Aluminum and silica in drinking water and the risk of Alzheimer's disease or cognitive decline: findings from 15-year followup of the PAQUID cohort, Am J Epidemiol, vol.169, issue.4, pp.489-96, 2009.

L. O. Killin, J. M. Starr, I. J. Shiue, and T. C. Russ, Environmental risk factors for dementia: a systematic review, BMC geriatrics, vol.16, issue.1, p.175, 2016.

C. A. Reyes-ortiz, Y. Kuo, A. R. Dinuzzo, L. A. Ray, M. A. Raji et al., Near vision impairment predicts cognitive decline: data from the Hispanic Established Populations for Epidemiologic Studies of the Elderly, J Am Geriatr Soc, vol.53, issue.4, pp.681-687, 2005.

T. E. Clemons, M. W. Rankin, and W. L. Mcbee, Age-Related Eye Disease Study Research G. Cognitive impairment in the Age-Related Eye Disease Study: AREDS report no, Arch Ophthalmol, vol.124, issue.16, pp.537-580, 2006.

M. Rogers and K. M. Langa, Untreated poor vision: a contributing factor to late-life dementia, Am J Epidemiol, vol.171, issue.6, pp.728-763, 2010.

L. J. Whalley, F. D. Dick, and G. Mcneill, A life-course approach to the aetiology of late-onset dementias, Lancet Neurol, vol.5, issue.1, pp.87-96, 2006.

L. J. Launer, The epidemiologic study of dementia: a life-long quest?, Neurobiology of aging, vol.26, issue.3, pp.335-375, 2005.

J. A. Mortimer, Brain reserve and the clinical expression of Alzheimer's disease, Geriatrics, vol.52, issue.2, pp.50-53, 1997.

M. Muller, S. Sigurdsson, O. Kjartansson, P. V. Jonsson, M. Garcia et al., Birth size and brain function 75 years later, Pediatrics, vol.134, issue.4, pp.761-70, 2014.

C. Qiu, W. Xu, and L. Fratiglioni, Vascular and psychosocial factors in Alzheimer's disease: epidemiological evidence toward intervention, Journal of Alzheimer's disease : JAD, vol.20, issue.3, pp.689-97, 2010.

C. Qiu, Preventing Alzheimer's disease by targeting vascular risk factors: hope and gap, Journal of Alzheimer's disease : JAD, vol.32, issue.3, pp.721-752, 2012.

A. M. Tolppanen, A. Solomon, H. Soininen, and M. Kivipelto, Midlife vascular risk factors and Alzheimer's disease: evidence from epidemiological studies, Journal of Alzheimer's disease : JAD, vol.32, issue.3, pp.531-571, 2012.

R. F. Gottesman, A. L. Schneider, Y. Zhou, J. Coresh, E. Green et al., Association Between Midlife Vascular Risk Factors and Estimated Brain Amyloid Deposition, JAMA, vol.317, issue.14, pp.1443-50, 2017.

C. Samieri, Q. Sun, M. K. Townsend, S. E. Chiuve, O. I. Okereke et al., The association between dietary patterns at midlife and health in aging: an observational study, Annals of internal medicine, vol.159, issue.9, pp.584-91, 2013.

M. Baumgart, H. M. Snyder, M. C. Carrillo, S. Fazio, H. Kim et al., Summary of the evidence on modifiable risk factors for cognitive decline and dementia: A population-based perspective, Alzheimers Dement, vol.11, issue.6, pp.718-744, 2015.

R. Brookmeyer, S. Gray, and C. Kawas, Projections of Alzheimer's disease in the United States and the public health impact of delaying disease onset, Am J Public Health, vol.88, issue.9, pp.1337-1379, 1998.

S. Norton, F. E. Matthews, D. E. Barnes, K. Yaffe, and C. Brayne, Potential for primary prevention of Alzheimer's disease: an analysis of population-based data, Lancet Neurol, vol.13, issue.8, pp.788-94, 2014.

R. F. De-bruijn, M. J. Bos, M. L. Portegies, A. Hofman, O. H. Franco et al., The potential for prevention of dementia across two decades: the prospective, population-based Rotterdam Study, BMC medicine, vol.13, p.132, 2015.

J. W. Williams, B. L. Plassman, J. Burke, and S. Benjamin, Preventing Alzheimer's disease and cognitive decline, Available from, 2010.

E. B. Larson, K. Yaffe, and K. M. Langa, New insights into the dementia epidemic, N Engl J Med, vol.369, issue.24, pp.2275-2282, 2013.

Y. T. Wu, A. S. Beiser, M. Breteler, L. Fratiglioni, C. Helmer et al., The changing prevalence and incidence of dementia over time-current evidence, Nature reviews Neurology, vol.13, issue.6, pp.327-366, 2017.

M. Prince, G. C. Ali, M. Guerchet, A. M. Prina, E. Albanese et al., Recent global trends in the prevalence and incidence of dementia, and survival with dementia, vol.8, p.23, 2016.

C. Qiu, E. Strauss, L. Bäckman, B. Winblad, and L. Fratiglioni, Twenty-year changes in dementia occurrence suggest decreasing incidence in central, Neurology, vol.80, issue.20, pp.1888-94, 2013.

P. Wiberg, M. Waern, E. Billstedt, S. Ostling, and I. Skoog, Secular trends in the prevalence of dementia and depression in Swedish septuagenarians 1976-2006. Psychological medicine, vol.43, pp.2627-2661, 2013.

A. Wimo, B. M. Sjolund, A. Skoldunger, C. Qiu, I. Klarin et al., Cohort Effects in the Prevalence and Survival of People with Dementia in a Rural Area in Northern Sweden, Journal of Alzheimer's disease : JAD, vol.50, issue.2, pp.387-96, 2016.

F. E. Matthews, A. Arthur, L. E. Barnes, J. Bond, C. Jagger et al., A two-decade comparison of prevalence of dementia in individuals aged 65 years and older from three geographical areas of England: results of the Cognitive Function and Ageing Study I and II, Lancet, vol.382, issue.9902, pp.1405-1417, 2013.

A. Lobo, P. Saz, M. G. Dia, J. L. De-la-camara, C. Ventura et al., Prevalence of dementia in a southern European population in two different time periods: the ZARADEMP Project, Acta psychiatrica Scandinavica, vol.116, issue.4, pp.299-307, 2007.

K. Peres, C. Brayne, F. Matharan, L. Grasset, C. Helmer et al., Trends in Prevalence of Dementia in French Farmers from Two Epidemiological Cohorts, J Am Geriatr Soc, vol.65, issue.2, pp.415-435, 2017.

K. S. Hall, S. Gao, O. Baiyewu, K. A. Lane, O. Gureje et al., Prevalence rates for dementia and Alzheimer's disease in African Americans: 1992 versus, Alzheimers Dement, vol.5, issue.3, pp.227-260, 2001.

K. M. Langa, E. B. Larson, E. M. Crimmins, J. D. Faul, D. A. Levine et al., A Comparison of the Prevalence of Dementia in the United States in 2000 and 2012, JAMA Intern Med, vol.177, issue.1, pp.51-59, 2017.

K. M. Langa, E. B. Larson, J. H. Karlawish, D. M. Cutler, M. U. Kabeto et al., Trends in the prevalence and mortality of cognitive impairment in the United States: is there evidence of a compression of cognitive morbidity?, Alzheimers Dement, vol.4, issue.2, pp.134-178, 2008.

G. Doblhammer, A. Fink, and T. Fritze, Short-term trends in dementia prevalence in Germany between the years, Alzheimers Dement, vol.11, issue.3, pp.291-300, 2007.

K. C. Manton, X. L. Gu, and S. V. Ukraintseva, Declining prevalence of dementia in the U.S. elderly population, Adv Gerontol, vol.16, pp.30-37, 2005.

W. A. Rocca, R. C. Petersen, D. S. Knopman, L. E. Hebert, D. A. Evans et al., Trends in the incidence and prevalence of Alzheimer's disease, dementia, and cognitive impairment in the United States, Alzheimers Dement, vol.7, issue.1, pp.80-93, 2011.

C. L. Satizabal, A. S. Beiser, V. Chouraki, G. Chene, C. Dufouil et al., Incidence of Dementia over Three Decades in the Framingham Heart Study, N Engl J Med, vol.374, issue.6, pp.523-555, 2016.

S. Gao, A. Ogunniyi, K. S. Hall, O. Baiyewu, F. W. Unverzagt et al., Dementia incidence declined in African-Americans but not in Yoruba, Alzheimers Dement, vol.12, issue.3, pp.244-51, 2016.

E. Schrijvers, B. Verhaaren, P. J. Koudstaal, A. Hofman, M. A. Ikram et al., Is dementia incidence declining?: Trends in dementia incidence since 1990 in the Rotterdam Study, Neurology, vol.78, pp.1456-63, 2012.

L. E. Hebert, J. L. Bienias, N. T. Aggarwal, R. S. Wilson, D. A. Bennett et al., Change in risk of Alzheimer disease over time, Neurology, vol.75, issue.9, pp.786-91, 2010.

G. Doblhammer, A. Fink, S. Zylla, and F. Willekens, Compression or expansion of dementia in Germany? An observational study of short-term trends in incidence and death rates of dementia between 2006/07 and 2009/10 based on German health insurance data, vol.7, p.66, 2015.

L. A. Sposato, M. K. Kapral, J. Fang, S. S. Gill, D. G. Hackam et al., Declining Incidence of Stroke and Dementia: Coincidence or Prevention Opportunity?, JAMA neurology, vol.72, issue.12, pp.1529-1560, 2015.
DOI : 10.1001/jamaneurol.2015.2816

URL : http://archneur.jamanetwork.com/data/journals/neur/934755/nld150009.pdf

S. Ukraintseva, F. Sloan, K. Arbeev, and A. Yashin, Increasing rates of dementia at time of declining mortality from stroke, Stroke, vol.37, issue.5, pp.1155-1164, 2006.

K. Y. Chan, W. Wang, J. J. Wu, L. Liu, E. Theodoratou et al., Epidemiology of Alzheimer's disease and other forms of dementia in China, 1990-2010: a systematic review and analysis, Lancet, vol.381, issue.9882, pp.2016-2039, 2013.

M. J. Dong, B. Peng, X. T. Lin, J. Zhao, Y. R. Zhou et al., The prevalence of dementia in the People's Republic of China: a systematic analysis of 1980-2004 studies, Age Ageing, vol.36, issue.6, pp.619-643, 2007.

Y. Zhang, Y. Xu, H. Nie, T. Lei, Y. Wu et al., Prevalence of dementia and major dementia subtypes in the Chinese populations: a meta-analysis of dementia prevalence surveys, Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia, vol.19, issue.10, pp.1333-1340, 1980.

R. Yu, P. H. Chau, S. M. Mcghee, W. L. Cheung, K. C. Chan et al., Trends in prevalence and mortality of dementia in elderly Hong Kong population: projections, disease burden, and implications for long-term care, International journal of Alzheimer's disease, p.406852, 2012.

H. H. Dodge, T. J. Buracchio, G. G. Fisher, Y. Kiyohara, K. Meguro et al., Trends in the prevalence of dementia in Japan, International journal of Alzheimer's disease, p.956354, 2012.

H. Okamura, S. Ishii, T. Ishii, and A. Eboshida, Prevalence of dementia in Japan: a systematic review, Dement Geriatr Cogn Disord, vol.36, issue.1-2, pp.111-119, 2013.

S. Li, F. Yan, G. Li, C. Chen, W. Zhang et al., Is the dementia rate increasing in Beijing? Prevalence and incidence of dementia 10 years later in an urban elderly population, Acta psychiatrica Scandinavica, vol.115, issue.1, pp.73-82, 2007.

A. Sekita, T. Ninomiya, Y. Tanizaki, Y. Doi, J. Hata et al., Trends in prevalence of Alzheimer's disease and vascular dementia in a Japanese community: the Hisayama Study, Acta psychiatrica Scandinavica, vol.122, issue.4, pp.319-344, 2010.

T. Ohara, J. Hata, D. Yoshida, N. Mukai, M. Nagata et al., Trends in dementia prevalence, incidence, and survival rate in a Japanese community, Neurology, vol.88, issue.20, pp.1925-1957, 2017.
DOI : 10.1212/wnl.0000000000003932

K. Steenland, J. Macneil, I. Vega, and A. Levey, Recent trends in Alzheimer disease mortality in the United States, vol.23, pp.165-70, 1999.

C. Sauvaget, I. Tsuji, M. N. Haan, and S. Hisamichi, Trends in dementia-free life expectancy among elderly members of a large health maintenance organization, International journal of epidemiology, vol.28, issue.6, pp.1110-1118, 1999.

V. Bordone, S. Scherbov, and N. Steiber, Smarter ever day: The deceleration of population ageing in terms of cognition, Intelligence, vol.52, pp.90-96, 2015.

N. Steiber, Population Aging at Cross-Roads: Diverging Secular Trends in Average Cognitive Functioning and Physical Health in the Older Population of Germany, PloS one, vol.10, issue.8, p.136583, 2015.

K. Christensen, M. Thinggaard, A. Oksuzyan, T. Steenstrup, K. Andersen-ranberg et al., Physical and cognitive functioning of people older than 90 years: a comparison of two Danish cohorts born 10 years apart, Lancet, vol.382, issue.9903, pp.1507-1520, 2013.

J. De-rotrou, Y. H. Wu, J. B. Mabire, F. Moulin, L. W. De-jong et al., Does cognitive function increase over time in the healthy elderly?, PloS one, vol.8, issue.11, p.78646, 2013.

D. J. Llewellyn and F. E. Matthews, Increasing levels of semantic verbal fluency in elderly English adults. Neuropsychology, development, and cognition Section B, Aging, neuropsychology and cognition, vol.16, pp.433-478, 2009.

S. Sacuiu, D. Gustafson, M. Sjogren, X. Guo, S. Ostling et al., Secular changes in cognitive predictors of dementia and mortality in 70-year-olds, Neurology, vol.75, issue.9, pp.779-85, 2010.

H. H. Dodge, J. Zhu, C. W. Lee, C. C. Chang, and M. Ganguli, Cohort effects in age-associated cognitive trajectories. The journals of gerontology Series A, Biological sciences and medical sciences, vol.69, pp.687-94, 2014.

H. H. Dodge, J. Zhu, T. F. Hughes, B. E. Snitz, C. H. Chang et al., Cohort effects in verbal memory function and practice effects: a population-based study, International psychogeriatrics / IPA, vol.29, issue.1, pp.137-185, 2017.

D. Gerstorf, N. Ram, C. Hoppmann, S. L. Willis, and K. W. Schaie, Cohort differences in cognitive aging and terminal decline in the Seattle Longitudinal Study, Developmental psychology, vol.47, issue.4, pp.1026-1067, 2011.

D. Finkel, C. A. Reynolds, J. J. Mcardle, and N. L. Pedersen, Cohort differences in trajectories of cognitive aging. The journals of gerontology Series B, Psychological sciences and social sciences, vol.62, pp.286-94, 2007.

E. M. Zelinski and R. F. Kennison, Not your parents' test scores: cohort reduces psychometric aging effects, Psychol Aging, vol.22, issue.3, pp.546-57, 2007.
DOI : 10.1037/0882-7974.22.3.546

URL : http://europepmc.org/articles/pmc4169292?pdf=render

P. Karlsson, V. Thorvaldsson, I. Skoog, P. Gudmundsson, and B. Johansson, Birth cohort differences in fluid cognition in old age: comparisons of trends in levels and change trajectories over 30 years in three population-based samples, Psychol Aging, vol.30, issue.1, pp.83-94, 2015.

A. Brailean, M. Huisman, M. Prince, A. M. Prina, D. J. Deeg et al., Cohort Differences in Cognitive Aging in the Longitudinal Aging Study Amsterdam. The journals of gerontology Series B, Psychological sciences and social sciences, 2016.

E. M. Crimmins, Trends in the health of the elderly, Annu Rev Public Health, vol.25, pp.79-98, 2004.

D. M. Cutler, Declining disability among the elderly, Health Aff (Millwood), vol.20, issue.6, pp.11-27, 2001.

K. G. Manton, Recent declines in chronic disability in the elderly U.S. population: risk factors and future dynamics, Annu Rev Public Health, vol.29, pp.91-113, 2008.

C. Jagger, R. J. Matthews, F. E. Matthews, N. A. Spiers, J. Nickson et al., Cohort differences in disease and disability in the young-old: findings from the MRC Cognitive Function and Ageing Study (MRC-CFAS), BMC public health, vol.7, p.156, 2007.

T. E. Seeman, S. S. Merkin, E. M. Crimmins, and A. S. Karlamangla, Disability trends among older Americans: National Health And Nutrition Examination Surveys, Am J Public Health, vol.100, issue.1, pp.100-107, 1988.
DOI : 10.2105/ajph.2008.157388

URL : https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2791257/pdf

V. A. Freedman, L. G. Martin, and R. F. Schoeni, Recent trends in disability and functioning among older adults in the United States: a systematic review, JAMA, vol.288, issue.24, pp.3137-3183, 2002.

E. Heikkinen, M. Kauppinen, T. Rantanen, R. Leinonen, T. M. Lyyra et al., Cohort differences in health, functioning and physical activity in the young-old Finnish population, Aging clinical and experimental research, vol.23, issue.2, pp.126-160, 2011.

Q. Feng, Z. Zhen, D. Gu, B. Wu, P. W. Duncan et al., The journals of gerontology Series B, Psychological sciences and social sciences, ADL and IADL disability in community-dwelling older adults in, vol.68, pp.476-85, 1998.

S. H. Allaire, M. P. Lavalley, S. R. Evans, O. Connor, G. T. Kelly-hayes et al., Evidence for decline in disability and improved health among persons aged 55 to 70 years: the Framingham Heart Study, Am J Public Health, vol.89, issue.11, pp.1678-83, 1999.

K. G. Manton and X. Gu, Changes in the prevalence of chronic disability in the United States black and nonblack population above age 65 from 1982 to 1999, Proceedings of the National Academy of Sciences of the United States of America, vol.98, issue.11, pp.6354-6363, 2001.

K. G. Manton, L. Corder, and E. Stallard, Chronic disability trends in elderly United States populations: 1982-1994, Proceedings of the National Academy of Sciences of the United States of America, vol.94, issue.6, pp.2593-2601, 1997.

E. M. Crimmins, Y. Saito, and S. L. Reynolds, Further evidence on recent trends in the prevalence and incidence of disability among older Americans from two sources: the LSOA and the NHIS. The journals of gerontology Series B, Psychological sciences and social sciences, vol.52, pp.59-71, 1997.

K. Peres, C. Helmer, L. Letenneur, H. Jacqmin-gadda, and P. Barberger-gateau, Ten-year change in disability prevalence and related factors in two generations of French elderly community dwellers: data from the PAQUID study, Aging clinical and experimental research, vol.17, issue.3, pp.229-264, 2005.

I. P. Donald, C. Foy, and C. Jagger, Trends in disability prevalence over 10 years in older people living in Gloucestershire, Age Ageing, vol.39, issue.3, pp.337-379, 2010.

H. Falk, L. Johansson, S. Ostling, T. Agerholm, K. Staun et al., Functional disability and ability 75-year-olds: a comparison of two Swedish cohorts born 30 years apart, Age Ageing, vol.43, issue.5, pp.636-677, 2014.

S. Galea and M. Tracy, Participation rates in epidemiologic studies, Annals of epidemiology, vol.17, issue.9, pp.643-53, 2007.

L. J. Launer, A. W. Wind, and D. J. Deeg, Nonresponse pattern and bias in a community-based crosssectional study of cognitive functioning among the elderly, Am J Epidemiol, vol.139, issue.8, pp.803-815, 1994.

R. Little and D. Rubin, Statistical analysis with missing data, 1987.

M. D. Chatfield, C. E. Brayne, and F. E. Matthews, A systematic literature review of attrition between waves in longitudinal studies in the elderly shows a consistent pattern of dropout between differing studies, Journal of clinical epidemiology, vol.58, issue.1, pp.13-22, 2005.

K. M. Langa and D. A. Levine, The diagnosis and management of mild cognitive impairment: a clinical review, JAMA, vol.312, issue.23, pp.2551-61, 2014.

R. S. Wilson, L. A. Beckett, J. L. Bienias, D. A. Evans, and D. A. Bennett, Terminal decline in cognitive function, Neurology, vol.60, issue.11, pp.1782-1789, 2003.
DOI : 10.1212/01.wnl.0000068019.60901.c1

. 3c-study-group, Vascular factors and risk of dementia: design of the Three-City Study and baseline characteristics of the study population, Neuroepidemiology, vol.22, issue.6, pp.316-341, 2003.

, Cognitive function and dementia in six areas of England and Wales: the distribution of MMSE and prevalence of GMS organicity level in the MRC CFA Study. The Medical Research Council Cognitive Function and Ageing Study (MRC CFAS). Psychological medicine, vol.28, pp.319-354, 1998.

M. Gagnon, L. Letenneur, J. F. Dartigues, D. Commenges, J. M. Orgogozo et al., Validity of the Mini-Mental State examination as a screening instrument for cognitive impairment and dementia in French elderly community residents, Neuroepidemiology, vol.9, issue.3, pp.143-50, 1990.

M. F. Folstein, S. E. Folstein, and P. R. Mchugh, Mini-mental state". A practical method for grading the cognitive state of patients for the clinician, J Psychiatr Res, vol.12, issue.3, pp.189-98, 1975.

B. Isaacs and A. T. Kennie, The Set test as an aid to the detection of dementia in old people. The British journal of psychiatry : the journal of mental science, vol.123, pp.467-70, 1973.

A. Benton, Applications cliniques et expérimentales. Deuxième édition française, 1965.

M. P. Lawton and E. M. Brody, Assessment of older people: self-maintaining and instrumental activities of daily living, The Gerontologist, vol.9, issue.3, pp.179-86, 1969.

P. Barberger-gateau, D. Commenges, M. Gagnon, L. Letenneur, C. Sauvel et al., Instrumental activities of daily living as a screening tool for cognitive impairment and dementia in elderly community dwellers, J Am Geriatr Soc, vol.40, issue.11, pp.1129-1163, 1992.

K. Pérès, V. Chrysostome, C. Fabrigoule, J. M. Orgogozo, J. F. Dartigues et al., Restriction in complex activities of daily living in MCI: impact on outcome, Neurology, vol.67, issue.3, pp.461-467, 2006.

J. R. Copeland, M. E. Dewey, A. S. Henderson, D. W. Kay, C. D. Neal et al., The Geriatric Mental State (GMS) used in the community: replication studies of the computerized diagnosis AGECAT. Psychological medicine, vol.18, pp.219-242, 1988.

J. R. Copeland, M. E. Dewey, and G. Hm, Dementia and depression in elderly persons: AGECAT compared with DSM III and pervasive illness, International journal of geriatric psychiatry, vol.5, pp.45-51, 1990.
DOI : 10.1002/gps.930050108

C. Touraine, C. Helmer, and P. Joly, Predictions in an illness-death model, Stat Methods Med Res, vol.25, issue.4, pp.1452-70, 2016.
DOI : 10.1177/0962280213489234

N. M. Laird and J. H. Ware, Random-effects models for longitudinal data, Biometrics, vol.38, issue.4, pp.963-74, 1982.

C. Proust-lima, J. F. Dartigues, and H. Jacqmin-gadda, Misuse of the linear mixed model when evaluating risk factors of cognitive decline, Am J Epidemiol, vol.174, issue.9, pp.1077-88, 2011.
URL : https://hal.archives-ouvertes.fr/inserm-00621015

H. Amieva, H. Mokri, L. Goff, M. Meillon, C. Jacqmin-gadda et al., Compensatory mechanisms in higher-educated subjects with Alzheimer's disease: a study of 20 years of cognitive decline, Brain, vol.137, pp.1167-75, 2014.

Y. Stern, Cognitive reserve: implications for assessment and intervention, Folia Phoniatr Logop, vol.65, issue.2, pp.49-54, 2013.

, Higher use of psychotropic drugs among people with Alzheimer's in their nineties. Nursing standard (Royal College of Nursing, vol.31, p.17, 1987.

Y. Stern, Cognitive reserve in ageing and Alzheimer's disease, Lancet Neurol, vol.11, issue.11, pp.1006-1018, 2012.

Y. Stern, Cognitive reserve, Neuropsychologia, vol.47, issue.10, pp.2015-2043, 2009.
URL : https://hal.archives-ouvertes.fr/hal-00863749

J. R. Flynn, The mean IQ of American: Massive gains 1932 to 1978, Psychological bulletin, vol.95, pp.29-51, 1984.

T. Grimmer, S. Beringer, V. Kehl, P. Alexopoulos, A. Busche et al., Trends of patient referral to a memory clinic and towards earlier diagnosis from 1985-2009, International psychogeriatrics / IPA, vol.27, issue.12, pp.1939-1983, 2015.

K. V. Papp, D. M. Rentz, E. C. Mormino, A. P. Schultz, R. E. Amariglio et al., Cued memory decline in biomarker-defined preclinical Alzheimer disease, 2017.

C. Jagger, F. E. Matthews, P. Wohland, T. Fouweather, B. C. Stephan et al., A comparison of health expectancies over two decades in England: results of the Cognitive Function and Ageing Study I and II, Lancet, vol.387, pp.779-86, 2016.

K. Pérès, A. Edjolo, J. F. Dartigues, and P. Barberger-gateau, Recent Trends in Disability-Free Life Expectancy in the French Elderly: Twenty Years Follow-Up of the Paquid Cohort, Annual Review of Gerontology and Geriatrics, vol.33, issue.1, pp.293-311, 2013.

J. Sagardui-villamor, P. Guallar-castillon, M. Garcia-ferruelo, J. R. Banegas, and F. Rodriguez-artalejo, Trends in disability and disability-free life expectancy among elderly people in Spain: 1986-1999. The journals of gerontology Series A, Biological sciences and medical sciences, vol.60, pp.1028-1062, 2005.
DOI : 10.1093/gerona/60.8.1028

URL : https://academic.oup.com/biomedgerontology/article-pdf/60/8/1028/9733031/1028.pdf

K. G. Manton, X. Gu, and G. R. Lowrimore, Cohort changes in active life expectancy in the U.S. elderly population: experience from the 1982-2004 National Long-Term Care Survey. The journals of gerontology Series B, Psychological sciences and social sciences, vol.63, pp.269-81, 2008.

H. Van-oyen, B. Cox, S. Demarest, P. Deboosere, and V. Lorant, Trends in health expectancy indicators in the older adult population in Belgium between 1997 and, Eur J Ageing, vol.5, pp.137-183, 2004.

B. Jeune and H. Bronnum-hansen, Trends in health expectancy at age 65 for various health indicators, Eur J Ageing, vol.5, pp.279-85, 1987.

E. Cambois, A. Clavel, I. Romieu, and J. M. Robine, Trends in disability-free life expectancy at age 65 in France: consistent and diverging partterns according to the underlying disability measure, Eur J Ageing, vol.5, pp.287-98, 2008.

L. Lang, A. Clifford, L. Wei, D. Zhang, D. Leung et al., Prevalence and determinants of undetected dementia in the community: a systematic literature review and a meta-analysis, BMJ open, vol.7, issue.2, p.11146, 2017.

M. Lopponen, I. Raiha, R. Isoaho, T. Vahlberg, and S. L. Kivela, Diagnosing cognitive impairment and dementia in primary health care-a more active approach is needed, Age Ageing, vol.32, issue.6, pp.606-618, 2003.

J. Bond, C. Stave, A. Sganga, B. O&apos;connell, and R. L. Stanley, Inequalities in dementia care across Europe: key findings of the Facing Dementia Survey, Int J Clin Pract Suppl, issue.146, pp.8-14, 2005.

J. G. Kosteniuk, D. G. Morgan, O. Connell, M. E. Kirk, A. Crossley et al., Simultaneous temporal trends in dementia incidence and prevalence, 2005-2013: a population-based retrospective cohort study in Saskatchewan, Canada. International psychogeriatrics / IPA, vol.28, issue.10, pp.1643-58, 2016.

E. F. Van-bussel, R. E. Arts, D. L. Nooyens, A. C. Coloma, P. M. De-waal et al., Dementia incidence trend over 1992-2014 in the Netherlands: Analysis of primary care data, PLoS medicine, vol.14, issue.3, p.1002235, 2017.

E. Farina, R. Fioravanti, R. Pignatti, M. Alberoni, F. Mantovani et al., Functional living skills assessment: a standardized measure of high-order activities of daily living in patients with dementia. European journal of physical and rehabilitation medicine, vol.46, pp.73-80, 2010.

M. F. Schwartz, M. Segal, T. Veramonti, M. Ferraro, and L. J. Buxbaum, The Naturalistic Action Test: a standardised assessment for everyday action impairment, Neuropsychological rehabilitation, vol.12, pp.311-350, 2002.

J. Wancata, A. Borjesson-hanson, S. Ostling, K. Sjogren, and I. Skoog, Diagnostic criteria influence dementia prevalence. The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry, vol.15, pp.1034-1079, 2007.
DOI : 10.1097/jgp.0b013e31813c6b6c

Y. T. Wu, C. Brayne, and F. E. Matthews, Prevalence of dementia in East Asia: a synthetic review of time trends, International journal of geriatric psychiatry, vol.30, issue.8, pp.793-801, 2015.

Y. T. Wu, H. Y. Lee, S. Norton, A. M. Prina, J. Fleming et al., Period, birth cohort and prevalence of dementia in mainland China, Hong Kong and Taiwan: a meta-analysis, International journal of geriatric psychiatry, vol.29, issue.12, pp.1212-1232, 2014.

C. Jagger, C. Gillies, F. Moscone, E. Cambois, H. Van-oyen et al., Inequalities in healthy life years in the 25 countries of the European Union in 2005: a cross-national metaregression analysis, Lancet, vol.372, issue.9656, pp.2124-2155, 2008.

J. A. Salomon, H. Wang, M. K. Freeman, T. Vos, A. D. Flaxman et al., Healthy life expectancy for 187 countries, 1990-2010: a systematic analysis for the Global Burden Disease Study, Lancet, vol.380, issue.9859, pp.2144-62, 2010.

R. C. Green, L. S. Schneider, D. A. Amato, A. P. Beelen, G. Wilcock et al., Effect of tarenflurbil on cognitive decline and activities of daily living in patients with mild Alzheimer disease: a randomized controlled trial, JAMA, vol.302, issue.23, pp.2557-64, 2009.

R. S. Doody, R. Raman, M. Farlow, T. Iwatsubo, B. Vellas et al., A phase 3 trial of semagacestat for treatment of Alzheimer's disease, N Engl J Med, vol.369, issue.4, pp.341-50, 2013.

R. S. Doody, R. G. Thomas, M. Farlow, T. Iwatsubo, B. Vellas et al., Phase 3 trials of solanezumab for mild-to-moderate Alzheimer's disease, N Engl J Med, vol.370, issue.4, pp.311-332, 2014.
DOI : 10.1056/nejmoa1312889

S. Salloway, R. Sperling, N. C. Fox, K. Blennow, W. Klunk et al., Two phase 3 trials of bapineuzumab in mild-to-moderate Alzheimer's disease, N Engl J Med, vol.370, issue.4, pp.322-355, 2014.
DOI : 10.1056/nejmoa1304839

URL : http://europepmc.org/articles/pmc4159618?pdf=render

R. J. Barro and J. Lee, A new data set of educational attainment in the world, The National Bureau of Economic Research, 2010.

N. Collaboration, Worldwide trends in blood pressure from 1975 to 2015: a pooled analysis of 1479 population-based measurement studies with 19.1 million participants, Lancet, vol.389, pp.37-55, 2017.

S. Koton, A. L. Schneider, W. D. Rosamond, E. Shahar, Y. Sang et al., Stroke incidence and mortality trends in US communities, JAMA, vol.312, issue.3, pp.259-68, 1987.

N. A. Khan, F. A. Mcalister, L. Pilote, A. Palepu, H. Quan et al., Temporal trends in stroke incidence in South Asian, Chinese and white patients: A population based analysis. PloS one, vol.12, p.175556, 2017.
DOI : 10.1371/journal.pone.0175556

URL : https://doi.org/10.1371/journal.pone.0175556

B. Ovbiagele, K. Ernstrom, D. Markovic, and R. Raman, Trends in antihypertensive drug prescription patterns among ambulatory stroke patients in the United States, vol.22, pp.568-75, 2000.
DOI : 10.1016/j.jstrokecerebrovasdis.2013.06.022

URL : http://europepmc.org/articles/pmc4084703?pdf=render

M. Zhou, M. Daubresse, R. S. Stafford, and G. C. Alexander, National trends in the ambulatory treatment of hypertension in the United States, PloS one, vol.10, issue.3, p.119292, 1997.

L. Clare, Y. T. Wu, J. C. Teale, C. Macleod, F. Matthews et al., Potentially modifiable lifestyle factors, cognitive reserve, and cognitive function in later life: A cross-sectional study, PLoS medicine, vol.14, issue.3, p.1002259, 2017.
DOI : 10.1371/journal.pmed.1002259

URL : https://journals.plos.org/plosmedicine/article/file?id=10.1371/journal.pmed.1002259&type=printable

T. N. Akbaraly, F. Portet, S. Fustinoni, J. F. Dartigues, S. Artero et al., Leisure activities and the risk of dementia in the elderly: results from the Three-City Study, Neurology, vol.73, issue.11, pp.854-61, 2009.
URL : https://hal.archives-ouvertes.fr/inserm-00426836

J. F. Dartigues, A. Foubert-samier, L. Goff, M. Viltard, M. Amieva et al., Playing board games, cognitive decline and dementia: a French population-based cohort study, BMJ open, vol.3, issue.8, p.2998, 2013.
DOI : 10.1136/bmjopen-2013-002998

URL : https://bmjopen.bmj.com/content/3/8/e002998.full.pdf

A. Foubert-samier, L. Goff, M. Helmer, C. Peres, K. Orgogozo et al., Change in leisure and social activities and risk of dementia in elderly cohort. The journal of nutrition, health & aging, vol.18, issue.10, pp.876-82, 2014.

R. F. Itzhaki, R. Lathe, B. J. Balin, M. J. Ball, E. L. Bearer et al., Microbes and Alzheimer's Disease, Journal of Alzheimer's disease : JAD, vol.51, issue.4, pp.979-84, 2016.

B. Lunenfeld and P. Stratton, The clinical consequences of an ageing world and preventive strategies, Best Pract Res Clin Obstet Gynaecol, vol.27, issue.5, pp.643-59, 2013.
DOI : 10.1016/j.bpobgyn.2013.02.005

URL : http://europepmc.org/articles/pmc3776003?pdf=render

, Policies and priority interventions for healthy ageing, 2012.

P. M. Kearney, M. Whelton, K. Reynolds, P. Muntner, P. K. Whelton et al., Global burden of hypertension: analysis of worldwide data, Lancet, vol.365, issue.9455, pp.217-240, 2005.

C. D. Furberg, J. E. Sealey, and J. D. Blumenfeld, Unsuccessfully Treated Hypertension: A Major Public Health Problem With a Potential Solution. American journal of hypertension, 2017.

N. Collaboration, Worldwide trends in diabetes since 1980: a pooled analysis of 751 population-based studies with 4.4 million participants, Lancet, vol.387, pp.1513-1543, 2016.

J. E. Shaw, R. A. Sicree, and P. Z. Zimmet, Global estimates of the prevalence of diabetes for 2010 and 2030. Diabetes research and clinical practice, vol.87, pp.4-14, 2010.

, Trends in adult body-mass index in 200 countries from 1975 to 2014: a pooled analysis of 1698 population-based measurement studies with 19.2 million participants, Lancet, vol.387, pp.1377-96, 2016.

A. D. Lopez, C. D. Mathers, M. Ezzati, D. T. Jamison, and C. Murray, Measuring the Global Burden of Disease and Risk Factors, 1990.

J. J. Miranda, S. Kinra, J. P. Casas, D. Smith, G. Ebrahim et al., Non-communicable diseases in lowand middle-income countries: context, determinants and health policy, Trop Med Int Health, vol.13, issue.10, pp.1225-1259, 2008.

A. R. Hosseinpoor, N. Bergen, A. Kunst, S. Harper, R. Guthold et al., Socioeconomic inequalities in risk factors for non communicable diseases in low-income and middle-income countries: results from the World Health Survey, BMC public health, vol.12, p.912, 2012.

A. R. Hosseinpoor, N. Bergen, S. Mendis, S. Harper, E. Verdes et al., Socioeconomic inequality in the prevalence of noncommunicable diseases in low-and middle-income countries: results from the World Health Survey, BMC public health, vol.12, p.474, 2012.

L. Mclaren, Socioeconomic status and obesity, Epidemiologic reviews, vol.29, pp.29-48, 2007.

J. P. Mackenbach, I. Stirbu, A. J. Roskam, M. M. Schaap, G. Menvielle et al., Socioeconomic inequalities in health in 22 European countries, N Engl J Med, vol.358, issue.23, pp.2468-81, 2008.

A. M. Clark, M. Desmeules, W. Luo, A. S. Duncan, and A. Wielgosz, Socioeconomic status and cardiovascular disease: risks and implications for care, Nat Rev Cardiol, vol.6, issue.11, pp.712-734, 2009.

C. L. Link and J. B. Mckinlay, Disparities in the prevalence of diabetes: is it race/ethnicity or socioeconomic status? Results from the Boston Area Community Health (BACH) survey, Ethnicity & disease, vol.19, issue.3, pp.288-92, 2009.

P. A. Braveman, C. Cubbin, S. Egerter, D. R. Williams, and E. Pamuk, Socioeconomic disparities in health in the United States: what the patterns tell us, Am J Public Health, vol.100, issue.1, pp.186-96, 2010.

S. Stringhini, A. Dugravot, M. Shipley, M. Goldberg, M. Zins et al., Health behaviours, socioeconomic status, and mortality: further analyses of the British Whitehall II and the French GAZEL prospective cohorts, PLoS medicine, vol.8, issue.2, p.1000419, 2011.
URL : https://hal.archives-ouvertes.fr/inserm-00598525

A. R. Hosseinpoor, S. Williams, J. A. Itani, L. Chatterji, and S. , Socioeconomic inequality in domains of health: results from the World Health Surveys, BMC public health, vol.12, 0198.

C. Ouvrard, C. Meillon, J. F. Dartigues, J. A. Avila-funes, and H. Amieva, Psychosocioeconomic Precariousness, Cognitive Decline and Risk of Developing Dementia: A 25-Year Study, Dement Geriatr Cogn Disord, vol.41, issue.3-4, pp.137-182, 2016.

G. K. Singh, Area deprivation and widening inequalities in US mortality, 1969-1998, Am J Public Health, vol.93, issue.7, pp.1137-1180, 2003.

F. Windenberger, S. Rican, E. Jougla, and G. Rey, Spatiotemporal association between deprivation and mortality: trends in France during the nineties, Eur J Public Health, vol.22, issue.3, pp.347-53, 2012.
URL : https://hal.archives-ouvertes.fr/inserm-00838342

S. Rueda, L. Artazcoz, and V. Navarro, Health inequalities among the elderly in western Europe, Journal of epidemiology and community health, vol.62, issue.6, pp.492-500, 2008.

J. P. Mackenbach, M. Karanikolos, and M. Mckee, The unequal health of Europeans: successes and failures of policies, Lancet, vol.381, issue.9872, pp.1125-1159, 2013.

E. H. Martinez-lapiscina, P. Clavero, E. Toledo, R. Estruch, J. Salas-salvado et al., Mediterranean diet improves cognition: the PREDIMED-NAVARRA randomised trial, Journal of neurology, vol.84, issue.12, pp.1318-1343, 2013.

S. Trompet, P. Van-vliet, A. J. De-craen, J. Jolles, B. M. Buckley et al., Pravastatin and cognitive function in the elderly. Results of the PROSPER study, Journal of neurology, vol.257, issue.1, pp.85-90, 2010.

A. Nilsson, K. Radeborg, I. Salo, and I. Bjorck, Effects of supplementation with n-3 polyunsaturated fatty acids on cognitive performance and cardiometabolic risk markers in healthy 51 to 72 years old subjects: a randomized controlled cross-over study, Nutr J, vol.11, p.99, 2012.

K. Yurko-mauro, D. Mccarthy, D. Rom, E. B. Nelson, A. S. Ryan et al., Beneficial effects of docosahexaenoic acid on cognition in age-related cognitive decline, Alzheimers Dement, vol.6, issue.6, pp.456-64, 2010.

J. C. Breitner, L. D. Baker, T. J. Montine, C. L. Meinert, C. G. Lyketsos et al., Extended results of the Alzheimer's disease anti-inflammatory prevention trial, Alzheimers Dement, vol.7, issue.4, pp.402-413, 2011.
DOI : 10.1016/j.jalz.2010.12.014

URL : http://europepmc.org/articles/pmc3149804?pdf=render

F. Forette, M. L. Seux, J. A. Staessen, L. Thijs, W. H. Birkenhager et al., Prevention of dementia in randomised double-blind placebo-controlled Systolic Hypertension in Europe (SystEur) trial, Lancet, vol.352, issue.9137, pp.1347-51, 1998.

R. Peters, N. Beckett, F. Forette, J. Tuomilehto, R. Clarke et al., Incident dementia and blood pressure lowering in the Hypertension in the Very Elderly Trial cognitive function assessment (HYVET-COG): a double-blind, placebo controlled trial, Lancet Neurol, vol.7, issue.8, pp.683-692, 2008.

B. Mcguinness, S. Todd, P. Passmore, and R. Bullock, Blood pressure lowering in patients without prior cerebrovascular disease for prevention of cognitive impairment and dementia. The Cochrane database of systematic reviews, p.4034, 2009.

M. Angevaren, G. Aufdemkampe, H. J. Verhaar, A. Aleman, and L. Vanhees, Physical activity and enhanced fitness to improve cognitive function in older people without known cognitive impairment. The Cochrane database of systematic reviews, p.5381, 2008.
DOI : 10.1002/14651858.cd005381.pub3

J. Young, M. Angevaren, J. Rusted, and N. Tabet, Aerobic exercise to improve cognitive function in older people without known cognitive impairment. The Cochrane database of systematic reviews, vol.2015, p.5381

K. Ball, D. B. Berch, K. F. Helmers, J. B. Jobe, M. D. Leveck et al., Effects of cognitive training interventions with older adults: a randomized controlled trial, JAMA, vol.288, issue.18, pp.2271-81, 2002.

S. L. Willis, S. L. Tennstedt, M. Marsiske, K. Ball, J. Elias et al., Long-term effects of cognitive training on everyday functional outcomes in older adults, JAMA, vol.296, issue.23, pp.2805-2819, 2006.

K. V. Papp, S. J. Walsh, and P. J. Snyder, Immediate and delayed effects of cognitive interventions in healthy elderly: a review of current literature and future directions, Alzheimers Dement, vol.5, issue.1, pp.50-60, 2009.

M. Martin, C. L. Altgassen, A. M. Cameron, M. H. Zehnder, and F. , Cognition-based interventions for healthy older people and people with mild cognitive impairment. The Cochrane database of systematic reviews, vol.2011, p.6220

T. Ngandu, J. Lehtisalo, A. Solomon, E. Levalahti, S. Ahtiluoto et al., A 2 year multidomain intervention of diet, exercise, cognitive training, and vascular risk monitoring versus control to prevent cognitive decline in at-risk elderly people (FINGER): a randomised controlled trial, Lancet, vol.385, issue.9984, pp.2255-63, 2015.

S. Andrieu, S. Guyonnet, N. Coley, C. Cantet, M. Bonnefoy et al., Effect of long-term omega 3 polyunsaturated fatty acid supplementation with or without multidomain intervention on cognitive function in elderly adults with memory complaints (MAPT): a randomised, placebocontrolled trial, Lancet Neurol, vol.16, issue.5, pp.377-89, 2017.
URL : https://hal.archives-ouvertes.fr/hal-01604268

, Preventing Cognitive Decline and Dementia: A Way Forward.The National Academies Press, 2017.