Truncating mutations of hSNF5/INI1 in aggressive paediatric cancer, Nature, vol.394, pp.203-206, 1998. ,
Epigenetic antagonism between polycomb and SWI/SNF complexes during oncogenic transformation, Cancer Cell, vol.18, pp.316-328, 2010. ,
On the origin of cancer cells, Science, vol.123, pp.309-314, 1956. ,
The Emerging Hallmarks of Cancer Metabolism, Cell Metab, vol.23, pp.27-47, 2016. ,
Phosphoglycerate dehydrogenase diverts glycolytic flux and contributes to oncogenesis, Nat. Genet, vol.43, pp.869-874, 2011. ,
Functional genomics reveal that the serine synthesis pathway is essential in breast cancer, Nature, vol.476, pp.346-350, 2011. ,
The importance of serine metabolism in cancer, J. Cell Biol, vol.214, pp.249-257, 2016. ,
PHGDH amplification and altered glucose metabolism in human melanoma, Pigment Cell Melanoma Res, vol.24, pp.1112-1115, 2011. ,
Clinical Implication of Serine Metabolism-Associated Enzymes in Colon Cancer, Oncology, vol.89, pp.351-359, 2015. ,
EBV-miR-BART1 is involved in regulating metabolism-associated genes in nasopharyngeal carcinoma, Biochem. Biophys. Res. Commun, vol.436, pp.19-24, 2013. ,
Downregulation of phosphoglycerate dehydrogenase inhibits proliferation and enhances cisplatin sensitivity in cervical adenocarcinoma cells by regulating Bcl-2 and caspase-3, Cancer Biol. Ther, vol.16, pp.541-548, 2015. ,
Phosphoglycerate dehydrogenase induces glioma cells proliferation and invasion by stabilizing forkhead box M1, J. Neurooncol, vol.111, pp.245-255, 2013. ,
EWS/FLI is a Master Regulator of Metabolic Reprogramming in Ewing Sarcoma, Mol. Cancer Res. MCR, vol.15, pp.1517-1530, 2017. ,
glycine and one-carbon units: cancer metabolism in full circle, Nat. Rev. Cancer, vol.13, pp.572-583, 2013. ,
One-Carbon Metabolism in Health and Disease, Cell Metab, vol.25, pp.27-42, 2017. ,
The tumor suppressor hSNF5/INI1 modulates cell growth and actin cytoskeleton organization, Cancer Res, vol.64, pp.3406-3413, 2004. ,
Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles, PNAS, vol.102, pp.15545-15550, 2005. ,
SMARCB1 is required for widespread BAF complex-mediated activation of enhancers and bivalent promoters, Nat. Genet, 2017. ,
Atypical Teratoid/Rhabdoid Tumors Are Comprised of Three Epigenetic Subgroups with Distinct Enhancer Landscapes, Cancer Cell, vol.29, pp.379-393, 2016. ,
Transcriptional neoteny in the human brain, PNAS, vol.106, pp.5743-5748, 2009. ,
MSEA: a web-based tool to identify biologically meaningful patterns in quantitative metabolomic data, Nucleic Acids Res, vol.38, pp.71-77, 2010. ,
A PHGDH inhibitor reveals coordination of serine synthesis and onecarbon unit fate, Nat. Chem. Biol, vol.12, pp.452-458, 2016. ,
Dynamics of BAF-Polycomb complex opposition on heterochromatin in normal and oncogenic states, Nat. Genet, vol.49, pp.213-222, 2017. ,
SMARCB1-mediated SWI/SNF complex function is essential for enhancer regulation, Nat. Genet, vol.49, pp.289-295, 2017. ,
Mitochondrial ROS in cancer: initiators, amplifiers or an Achilles' heel?, Nat. Rev. Cancer, vol.14, pp.709-721, 2014. ,
Arid1a Has Context-Dependent Oncogenic and Tumor Suppressor Functions in Liver Cancer, Cancer Cell, vol.32, p.6, 2017. ,
Genome-Wide Profiles of Extra-cranial Malignant Rhabdoid Tumors Reveal Heterogeneity and Dysregulated Developmental Pathways, Cancer Cell, vol.29, pp.394-406, 2016. ,
,
but not glycine, supports one-carbon metabolism and proliferation of cancer cells, Cell Rep, vol.7, pp.1248-1258, 2014. ,
Molecular analysis of SNF2 and SNF5, genes required for expression of glucose-repressible genes in Saccharomyces cerevisiae, Mol. Cell. Biol, vol.6, pp.3643-3651, 1986. ,
SMARCB1(INI1)-deficient sinonasal basaloid carcinoma: a novel member of the expanding family of SMARCB1-deficient neoplasms, Am. J. Surg. Pathol, vol.38, pp.1274-1281, 2014. ,
SMARCB1 (INI-1)-deficient Sinonasal Carcinoma: A Series of 39 Cases Expanding the Morphologic and Clinicopathologic Spectrum of a Recently Described Entity, Am. J. Surg. Pathol, vol.41, pp.458-471, 2017. ,
Epigenomic enhancer profiling defines a signature of colon cancer, Science, vol.336, pp.736-739, 2012. ,
Modification of the phenotype of murine sarcoma virus-transformed cells by sodium butyrate. Effects on morphology and cytoskeletal elements, Exp. Cell Res, vol.102, pp.223-231, 1976. ,
SMARCB1/INI1 Involvement in Pediatric Chordoma: A Mutational and Immunohistochemical Analysis, Am. J. Surg. Pathol, vol.41, pp.56-61, 2017. ,
Exploitation of EP300 and CREBBP Lysine Acetyltransferases by Cancer. Cold Spring Harb, Perspect. Med, vol.7, 2017. ,
Non-targeted metabolomics of Brg1/Brm double-mutant cardiomyocytes reveals a novel role for SWI/SNF complexes in metabolic homeostasis, Metabolomics Off. J. Metabolomic Soc, vol.11, pp.1287-1301, 2015. ,
Expression of a beta-globin gene is enhanced by remote SV40 DNA sequences, Cell, vol.27, pp.299-308, 1981. ,
High-resolution profiling of histone methylations in the human genome, Cell, vol.129, pp.823-837, 2007. ,
Metabolic Signaling to Chromatin, Cold Spring Harb. Perspect. Biol, vol.8, 2016. ,
Reexpression of hSNF5/INI1/BAF47 in pediatric tumor cells leads to G1 arrest associated with induction of p16ink4a and activation of RB, Oncogene, vol.21, pp.5193-5203, 2002. ,
SMARCB1 (INI-1)-deficient carcinomas of the sinonasal tract, Am. J. Surg. Pathol, vol.38, pp.1282-1289, 2014. ,
Heterogeneity of neuroblastoma cell identity defined by transcriptional circuitries, Nat. Genet, vol.49, pp.1408-1413, 2017. ,
URL : https://hal.archives-ouvertes.fr/hal-01741718
Suppression of histone deacetylation in vivo and in vitro by sodium butyrate, J. Biol. Chem, vol.253, pp.3364-3366, 1978. ,
The chromatin remodeler Brg1 activates enhancer repertoires to establish B cell identity and modulate cell growth, Nat. Immunol, vol.16, pp.775-784, 2015. ,
Frequent hSNF5/INI1 germline mutations in patients with rhabdoid tumor, Clin. Cancer Res. Off. J. Am. Assoc. Cancer Res, vol.17, pp.31-38, 2011. ,
Extracranial rhabdoid tumours: what we have learned so far and future directions, Lancet Oncol, vol.14, pp.329-336, 2013. ,
, , 2011.
, Clinicopathologic comparison of familial versus sporadic atypical teratoid/rhabdoid tumors (AT/RT) of the central nervous system. Pediatr, Blood Cancer, vol.56, pp.1026-1031
Functional and mechanistic diversity of distal transcription enhancers, Cell, vol.144, pp.327-339, 2011. ,
Balanced Translocations Disrupting SMARCB1, 2016. ,
, Are Hallmark Recurrent Genetic Alterations in Renal Medullary Carcinomas, Eur. Urol, vol.69, pp.1055-1061
Genomic Characterization of Renal Medullary Carcinoma and Treatment Outcomes, Clin. Genitourin. Cancer, 2017. ,
Two differentially regulated mRNAs with different 5' ends encode secreted with intracellular forms of yeast invertase, Cell, vol.28, pp.145-154, 1982. ,
Mutants of yeast defective in sucrose utilization, Genetics, vol.98, pp.25-40, 1981. ,
Inhibition of histone deacetylases in cancer therapy: lessons from leukaemia, Br. J. Cancer, vol.114, pp.605-611, 2016. ,
Timeline: Chemotherapy and the war on cancer, Nat. Rev. Cancer, vol.5, pp.65-72, 2005. ,
Serine is a natural ligand and allosteric activator of pyruvate kinase M2, Nature, vol.491, pp.458-462, 2012. ,
Renal medullary carcinoma: rhabdoid features and the absence of INI1 expression as markers of aggressive behavior, Mod. Pathol. Off. J. U. S. Can. Acad. Pathol. Inc, vol.21, pp.647-652, 2008. ,
c-MYC interacts with INI1/hSNF5 and requires the SWI/SNF complex for transactivation function, Nat. Genet, vol.22, pp.102-105, 1999. ,
The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth, Nature, vol.452, pp.230-233, 2008. ,
, , 2016.
, Genome-Wide Profiles of Extra-cranial Malignant Rhabdoid Tumors Reveal Heterogeneity and Dysregulated Developmental Pathways, Cancer Cell, vol.29, pp.394-406
, , 2016.
, Genome-Wide Profiles of Extra-cranial Malignant Rhabdoid Tumors Reveal Heterogeneity and Dysregulated Developmental Pathways, Cancer Cell, vol.29, pp.394-406
The biology of chromatin remodeling complexes, Annu. Rev. Biochem, vol.78, pp.273-304, 2009. ,
Maintaining cell identity: PRC2-mediated regulation of transcription and cancer, Nat. Rev. Cancer, vol.16, pp.803-810, 2016. ,
Folates and one-carbon metabolism in plants and fungi, Phytochemistry, vol.45, pp.437-452, 1997. ,
Stimulation of GAL4 derivative binding to nucleosomal DNA by the yeast SWI/SNF complex, Science, vol.265, pp.53-60, 1994. ,
Histone H3K27ac separates active from poised enhancers and predicts developmental state, Proc. Natl. Acad. Sci. U. S. A, vol.107, pp.21931-21936, 2010. ,
Potent inhibition of DOT1L as treatment of MLL-fusion leukemia, Blood, vol.122, pp.1017-1025, 2013. ,
Cancer-associated IDH1 mutations produce 2hydroxyglutarate, Nature, vol.462, pp.739-744, 2009. ,
Environment Impacts the Metabolic Dependencies of Ras-Driven Non, Small Cell Lung Cancer. Cell Metab, vol.23, pp.517-528, 2016. ,
Cancer epigenetics: from mechanism to therapy, Cell, vol.150, pp.12-27, 2012. ,
Gene fusion with an ETS DNA-binding domain caused by chromosome translocation in human tumours, Nature, vol.359, pp.162-165, 1992. ,
BET bromodomain inhibition as a therapeutic strategy to target c-Myc, Cell, vol.146, pp.904-917, 2011. ,
Structure and ligand of a histone acetyltransferase bromodomain, Nature, vol.399, pp.491-496, 1999. ,
An oncogenic MYB feedback loop drives alternate cell fates in adenoid cystic carcinoma, Nat. Genet, vol.48, pp.265-272, 2016. ,
Composition and Function of Mutant Swi/Snf Complexes, Cell Rep, vol.18, pp.2124-2134, 2017. ,
Mapping and analysis of chromatin state dynamics in nine human cell types, Nature, vol.473, pp.43-49, 2011. ,
Human phosphoglycerate dehydrogenase produces the oncometabolite D-2-hydroxyglutarate, ACS Chem. Biol, vol.10, pp.510-516, 2015. ,
The history of cancer epigenetics, Nat. Rev. Cancer, vol.4, pp.143-153, 2004. ,
Leukemic IDH1 and IDH2 mutations result in a hypermethylation phenotype, disrupt TET2 function, and impair hematopoietic differentiation, Cancer Cell, vol.18, pp.553-567, 2010. ,
Epigenetic plasticity and the hallmarks of cancer, Science, vol.357, 2017. ,
Small cell ovarian carcinoma: genomic stability and responsiveness to therapeutics, Orphanet J. Rare Dis, vol.8, p.33, 2013. ,
Inactivation of the PBRM1 tumor suppressor gene amplifies the HIF-response in VHL-/-clear cell renal carcinoma, Proc. Natl. Acad. Sci. U. S. A, vol.114, pp.1027-1032, 2017. ,
Neuroblastoma is composed of two super-enhancer-associated differentiation states, Nat. Genet, vol.49, pp.1261-1266, 2017. ,
Activation of p53 sequence-specific DNA binding by acetylation of the p53 C-terminal domain, Cell, vol.90, pp.595-606, 1997. ,
Defining the role of mTOR in cancer, Cancer Cell, vol.12, pp.9-22, 2007. ,
Disruption of Ini1 leads to peri-implantation lethality and tumorigenesis in mice, Mol. Cell. Biol, vol.21, pp.3598-3603, 2001. ,
Molecular characterisation of SMARCB1 and NF2 in familial and sporadic schwannomatosis, J. Med. Genet, vol.45, pp.332-339, 2008. ,
The occurrence of intracranial rhabdoid tumours in mice depends on temporal control of Smarcb1 inactivation, Nat. Commun, vol.7, p.10421, 2016. ,
The hallmarks of cancer, Cell, vol.100, pp.57-70, 2000. ,
Hallmarks of cancer: the next generation, Cell, vol.144, pp.646-674, 2011. ,
ATP-dependent chromatin remodeling: genetics, genomics and mechanisms, Cell Res, vol.21, pp.396-420, 2011. ,
DOI : 10.1038/cr.2011.32
URL : https://www.nature.com/articles/cr201132.pdf
Nonsense mutation and inactivation of SMARCA4 (BRG1) in an atypical teratoid/rhabdoid tumor showing retained SMARCB1 (INI1) expression, Am. J. Surg. Pathol, vol.35, pp.933-935, 2011. ,
SMARCA4-mutated atypical teratoid/rhabdoid tumors are associated with inherited germline alterations and poor prognosis, Acta Neuropathol, vol.128, pp.453-456, 2014. ,
DOI : 10.1007/s00401-014-1323-x
Poorly differentiated chordoma with SMARCB1/INI1 loss: a distinct molecular entity with dismal prognosis, Acta Neuropathol, vol.132, pp.149-151, 2016. ,
Dnmt3L cooperates with the Dnmt3 family of de novo DNA methyltransferases to establish maternal imprints in mice, Dev. Camb. Engl, vol.129, pp.1983-1993, 2002. ,
, , 2011.
, Tet-mediated formation of 5-carboxylcytosine and its excision by TDG in mammalian DNA, Science, vol.333, pp.1303-1307
Distinct and predictive chromatin signatures of transcriptional promoters and enhancers in the human genome, Nat. Genet, vol.39, pp.311-318, 2007. ,
Histone modifications at human enhancers reflect global celltype-specific gene expression, Nature, vol.459, pp.108-112, 2009. ,
DOI : 10.1038/nature07829
URL : http://europepmc.org/articles/pmc2910248?pdf=render
Structural organization of the bcr gene and its role in the Ph' translocation, Nature, vol.315, pp.758-761, 1985. ,
Silencing of the VHL tumor-suppressor gene by DNA methylation in renal carcinoma, Proc. Natl. Acad. Sci. U. S. A, vol.91, pp.9700-9704, 1994. ,
Super-enhancers in the control of cell identity and disease, Cell, vol.155, pp.934-947, 2013. ,
Frequency, risk-factors and survival of children with atypical teratoid rhabdoid tumors (AT/RT) of the CNS diagnosed between 1988 and 2004, and registered to the German HIT database, Pediatr. Blood Cancer, vol.57, pp.978-985, 2011. ,
INI1-deficient tumors: diagnostic features and molecular genetics, Am. J. Surg. Pathol, vol.35, pp.47-63, 2011. ,
DOI : 10.1097/pas.0b013e31822b325b
Loss of INI1 expression is characteristic of both conventional and proximal-type epithelioid sarcoma, Am. J. Surg. Pathol, vol.33, pp.542-550, 2009. ,
DNMT3A mutations in acute myeloid leukemia: stability during disease evolution and clinical implications, Blood, vol.119, pp.559-568, 2012. ,
Phosphatidylserine is a critical modulator for Akt activation, J. Cell Biol, vol.192, pp.979-992, 2011. ,
SnapShot: histone modifications, Cell, vol.159, pp.458-458, 2014. ,
, p300/CBP and cancer, vol.23, pp.4225-4231, 2004.
Loss of the tumor suppressor Snf5 leads to aberrant activation of the Hedgehog-Gli pathway, Nat. Med, vol.16, pp.1429-1433, 2010. ,
Bromodomain Histone Readers and Cancer, J. Mol. Biol, vol.429, 2003. ,
Histone Lysine Demethylase Inhibitors. Cold Spring Harb, Perspect. Med, vol.7, 2017. ,
Recurrent SMARCA4 mutations in small cell carcinoma of the ovary, Nat. Genet, vol.46, pp.424-426, 2014. ,
Downregulation of Reactive Oxygen Species in Apoptosis, J. Cancer Prev, vol.21, pp.13-20, 2016. ,
Structure of Dnmt3a bound to Dnmt3L suggests a model for de novo DNA methylation, Nature, vol.449, pp.248-251, 2007. ,
Epithelioid malignant peripheral nerve sheath tumor: clinicopathologic analysis of 63 cases, Am. J. Surg. Pathol, vol.39, pp.673-682, 2015. ,
Atypical Teratoid/Rhabdoid Tumors Are Comprised of Three Epigenetic Subgroups with Distinct Enhancer Landscapes, Cancer Cell, vol.29, pp.379-393, 2016. ,
Dissecting the genomic complexity underlying medulloblastoma, Nature, vol.488, pp.100-105, 2012. ,
Essential role for de novo DNA methyltransferase Dnmt3a in paternal and maternal imprinting, Nature, vol.429, pp.900-903, 2004. ,
Role of the Dnmt3 family in de novo methylation of imprinted and repetitive sequences during male germ cell development in the mouse, Hum. Mol. Genet, vol.16, pp.2272-2280, 2007. ,
Metabolic control of epigenetics in cancer, Nat. Rev. Cancer, vol.16, pp.694-707, 2016. ,
The murine SNF5/INI1 chromatin remodeling factor is essential for embryonic development and tumor suppression, EMBO Rep, vol.1, pp.500-506, 2000. ,
The landscape of histone modifications across 1% of the human genome in five human cell lines, Genome Res, vol.17, pp.691-707, 2007. ,
Chromatin structure: a repeating unit of histones and DNA, Science, vol.184, pp.868-871, 1974. ,
Chromatin structure; oligomers of the histones, Science, vol.184, pp.865-868, 1974. ,
Genesis of chromatin and transcription dynamics in the origin of species, Cell, vol.161, pp.724-736, 2015. ,
Role of somatic cancer mutations in human protein lysine methyltransferases, Biochim. Biophys. Acta, vol.1846, pp.366-379, 2014. ,
DNA methylation and cancer, Adv. Genet, vol.70, pp.27-56, 2010. ,
Small molecule activation of PKM2 in cancer cells induces serine auxotrophy, Chem. Biol, vol.19, pp.1187-1198, 2012. ,
SMARCA4-deficient thoracic sarcoma: report of a case and insights into how to reach the diagnosis using limited samples and resources, Hum. Pathol, 2017. ,
Mutational heterogeneity in cancer and the search for new cancer-associated genes, Nature, vol.499, pp.214-218, 2013. ,
SMARCA4 inactivation defines a group of undifferentiated thoracic malignancies transcriptionally related to BAF-deficient sarcomas, Nat. Genet, vol.47, pp.1200-1205, 2015. ,
URL : https://hal.archives-ouvertes.fr/hal-01684775
DNMT3A mutations in acute myeloid leukemia, N. Engl. J. Med, vol.363, pp.2424-2433, 2010. ,
The Warburg Effect: How Does it Benefit Cancer Cells?, Trends Biochem. Sci, vol.41, pp.211-218, 2016. ,
Reactive oxygen species in cancer, Free Radic. Res, vol.44, pp.479-496, 2010. ,
, , 2013.
, Phosphoglycerate dehydrogenase induces glioma cells proliferation and invasion by stabilizing forkhead box M1, J. Neurooncol, vol.111, pp.245-255
Phosphoglycerate dehydrogenase diverts glycolytic flux and contributes to oncogenesis, Nat. Genet, vol.43, pp.869-874, 2011. ,
Selective inhibition of tumor oncogenes by disruption of super-enhancers, Cell, vol.153, pp.320-334, 2013. ,
Crystal structure of the nucleosome core particle at 2.8 A resolution, Nature, vol.389, pp.251-260, 1997. ,
Mitochondrial Deficiencies in the Predisposition to Paraganglioma, 2017. ,
CpG methylation within the 5' regulatory region of the BRCA1 gene is tumor specific and includes a putative CREB binding site, Oncogene, vol.16, pp.1161-1169, 1998. ,
Medulloblastoma stem cells: where development and cancer cross pathways, Pediatr. Res, vol.71, pp.516-522, 2012. ,
Recurring mutations found by sequencing an acute myeloid leukemia genome, N. Engl. J. Med, vol.361, pp.1058-1066, 2009. ,
Cancer metabolism: a therapeutic perspective, Nat. Rev. Clin. Oncol, vol.14, pp.11-31, 2017. ,
, , 2015.
, SWI/SNF chromatin remodeling and human malignancies, Annu. Rev. Pathol, vol.10, pp.145-171
SMARCA4-Mutated Atypical Teratoid/Rhabdoid Tumor with Retained BRG1 Expression. Pediatr, Blood Cancer, vol.63, pp.568-569, 2016. ,
S-Adenosylmethionine: a control switch that regulates liver function, FASEB J. Off. Publ. Fed. Am. Soc. Exp. Biol, vol.16, pp.15-26, 2002. ,
Methionine metabolism and liver disease, Annu. Rev. Nutr, vol.28, pp.273-293, 2008. ,
The tumor suppressor hSNF5/INI1 modulates cell growth and actin cytoskeleton organization, Cancer Res, vol.64, pp.3406-3413, 2004. ,
5' CpG island methylation is associated with transcriptional silencing of the tumour suppressor p16/CDKN2/MTS1 in human cancers, Nat. Med, vol.1, pp.686-692, 1995. ,
Rubinstein-Taybi syndrome: clinical features, genetic basis, diagnosis, and management, Ital. J. Pediatr, vol.41, p.4, 2015. ,
Structure of the catalytic domain of human DOT1L, a non-SET domain nucleosomal histone methyltransferase, Cell, vol.112, pp.711-723, 2003. ,
Loss of SMARCB1/INI1 expression in poorly differentiated chordomas, Acta Neuropathol, vol.120, pp.745-753, 2010. ,
, , 2005.
, SMARCB1/INI1 tumor suppressor gene is frequently inactivated in epithelioid sarcomas, Cancer Res, vol.65, pp.4012-4019
Activation of ?-catenin/TCF targets following loss of the tumor suppressor SNF5, Oncogene, vol.33, pp.933-938, 2014. ,
Targeting histone methyltransferases and demethylases in clinical trials for cancer therapy, Clin. Epigenetics, vol.8, p.57, 2016. ,
Drosophila SETs its sights on cancer: Trr/MLL3/4 COMPASS-like complexes in development and disease, Mol. Cell. Biol, vol.33, pp.1698-1701, 2013. ,
Chromatin signatures of cancer, Genes Dev, vol.29, pp.238-249, 2015. ,
The imprinted gene and parent-of-origin effect database, Nucleic Acids Res, vol.29, pp.275-276, 2001. ,
Identification of a small molecule inhibitor of 3-phosphoglycerate dehydrogenase to target serine biosynthesis in cancers, Proc. Natl. Acad. Sci. U. S. A, vol.113, pp.1778-1783, 2016. ,
SMARCB1 is required for widespread BAF complex-mediated activation of enhancers and bivalent promoters, Nat. Genet, 2017. ,
The SWI/SNF Protein PBRM1 Restrains VHL-Loss-Driven Clear Cell Renal Cell Carcinoma, Cell Rep, vol.18, pp.2893-2906, 2017. ,
Targeting epigenetic regulations in cancer, Acta Biochim. Biophys. Sin, vol.48, pp.97-109, 2016. ,
Medulloblastomics: the end of the beginning, Nat. Rev. Cancer, vol.12, pp.818-834, 2012. ,
The whole-genome landscape of medulloblastoma subtypes, Nature, vol.547, pp.311-317, 2017. ,
DNA methyltransferases Dnmt3a and Dnmt3b are essential for de novo methylation and mammalian development, Cell, vol.99, pp.247-257, 1999. ,
Interaction of protein kinase C with phosphatidylserine. 2. Specificity and regulation, Biochemistry (Mosc.), vol.31, pp.4667-4673, 1992. ,
A PHGDH inhibitor reveals coordination of serine synthesis and one-carbon unit fate, Nat. Chem. Biol, vol.12, pp.452-458, 2016. ,
Mediator kinase inhibition further activates super-enhancer-associated genes in AML, Nature, vol.526, pp.273-276, 2015. ,
The role of genomic imprinting in biology and disease: an expanding view, Nat. Rev. Genet, vol.15, pp.517-530, 2014. ,
Emerging epigenetic targets and therapies in cancer medicine, Cancer Discov, vol.2, pp.405-413, 2012. ,
Functional genomics reveal that the serine synthesis pathway is essential in breast cancer, Nature, vol.476, pp.346-350, 2011. ,
Medulloblastoma exome sequencing uncovers subtype-specific somatic mutations, Nature, vol.488, pp.106-110, 2012. ,
Targeting MYCN in neuroblastoma by BET bromodomain inhibition, Cancer Discov, vol.3, pp.308-323, 2013. ,
Small cell carcinoma of the ovary, hypercalcemic type, displays frequent inactivating germline and somatic mutations in SMARCA4, Nat. Genet, vol.46, pp.427-429, 2014. ,
Hijacked in cancer: the KMT2 (MLL) family of methyltransferases, Nat. Rev. Cancer, vol.15, pp.334-346, 2015. ,
Loss of TET2 in hematopoietic cells leads to DNA hypermethylation of active enhancers and induction of leukemogenesis, Genes Dev, vol.29, pp.910-922, 2015. ,
Embryonic signature distinguishes pediatric and adult rhabdoid tumors from other SMARCB1-deficient cancers, Oncotarget, vol.8, pp.34245-34257, 2017. ,
n-Butyrate causes histone modification in HeLa and Friend erythroleukaemia cells, Nature, vol.268, pp.462-464, 1977. ,
, , 2000.
, Haploinsufficiency of Snf5 (integrase interactor 1) predisposes to malignant rhabdoid tumors in mice, Proc. Natl. Acad. Sci. U. S. A, vol.97, pp.13796-13800
Novel mutations target distinct subgroups of medulloblastoma, Nature, vol.488, pp.43-48, 2012. ,
An inhibitor of mutant IDH1 delays growth and promotes differentiation of glioma cells, Science, vol.340, pp.626-630, 2013. ,
Histone acetyltransferases, Annu. Rev. Biochem, vol.70, pp.81-120, 2001. ,
, , 2017.
, SMARCA4-deficient thoracic sarcoma: a distinctive clinicopathological entity with undifferentiated rhabdoid morphology and aggressive behavior
Germline nonsense mutation and somatic inactivation of SMARCA4/BRG1 in a family with rhabdoid tumor predisposition syndrome, Am. J. Hum. Genet, vol.86, pp.279-284, 2010. ,
TET proteins and the control of cytosine demethylation in cancer, Genome Med, vol.7, p.9, 2015. ,
HIF-1: upstream and downstream of cancer metabolism, Curr. Opin. Genet. Dev, vol.20, pp.51-56, 2010. ,
Loss of Snf5 Induces Formation of an Aberrant SWI/SNF Complex, Cell Rep, vol.18, pp.2135-2147, 2017. ,
Discovery of cancer drug targets by CRISPR-Cas9 screening of protein domains, Nat. Biotechnol, vol.33, pp.661-667, 2015. ,
Histone demethylation mediated by the nuclear amine oxidase homolog LSD1, Cell, vol.119, pp.941-953, 2004. ,
Role of reactive oxygen species (ROS) in apoptosis induction, Apoptosis Int. J. Program. Cell Death, vol.5, pp.415-418, 2000. ,
Loss of pRb expression in pituitary adenomas is associated with methylation of the RB1 CpG island, Cancer Res, vol.60, pp.1211-1216, 2000. ,
SMARCB1 mutations in schwannomatosis and genotype correlations with rhabdoid tumors, Cancer Genet, vol.207, pp.373-378, 2014. ,
Smarca4 ATPase mutations disrupt direct eviction of PRC1 from chromatin, Nat. Genet, vol.49, pp.282-288, 2017. ,
DOT1L/KMT4 recruitment and H3K79 methylation are ubiquitously coupled with gene transcription in mammalian cells, Mol. Cell. Biol, vol.28, pp.2825-2839, 2008. ,
Metabolic control of methylation and acetylation, Curr. Opin. Chem. Biol, vol.30, pp.52-60, 2016. ,
Arid1a Has Context-Dependent Oncogenic and Tumor Suppressor Functions in Liver Cancer, Cancer Cell, vol.32, pp.574-589, 2017. ,
Conversion of 5-methylcytosine to 5hydroxymethylcytosine in mammalian DNA by MLL partner TET1, Science, vol.324, pp.930-935, 2009. ,
EWS/FLI is a Master Regulator of Metabolic Reprogramming in Ewing Sarcoma, Mol. Cancer Res. MCR, 2017. ,
Molecular subgroups of medulloblastoma: the current consensus, Acta Neuropathol, vol.123, pp.465-472, 2012. ,
Role of glutathione in cancer progression and chemoresistance, Oxid. Med. Cell. Longev, p.972913, 2013. ,
Validating and enabling phosphoglycerate dehydrogenase (PHGDH) as a target for fragmentbased drug discovery in PHGDH-amplified breast cancer, Oncotarget, 2016. ,
DOI : 10.18632/oncotarget.11487
URL : http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=view&path%5B%5D=11487&path%5B%5D=36386
An embryonic origin for medulloblastoma, New Biol, vol.3, pp.364-371, 1991. ,
Understanding the Warburg effect: the metabolic requirements of cell proliferation, Science, vol.324, pp.1029-1033, 2009. ,
Truncating mutations of hSNF5/INI1 in aggressive paediatric cancer, Nature, vol.394, pp.203-206, 1998. ,
DOI : 10.1038/28212
Overexpression of phosphoserine aminotransferase PSAT1 stimulates cell growth and increases chemoresistance of colon cancer cells, Mol. Cancer, vol.7, p.14, 2008. ,
Genomic views of distant-acting enhancers, Nature, vol.461, pp.199-205, 2009. ,
DOI : 10.1038/nature08451
URL : http://europepmc.org/articles/pmc2923221?pdf=render
Transcriptional repression mediated by the human polycombgroup protein EED involves histone deacetylation, Nat. Commun, vol.23, pp.474-478, 1999. ,
A double take on bivalent promoters, Genes Dev, vol.27, pp.1318-1338, 2013. ,
DOI : 10.1101/gad.219626.113
URL : http://genesdev.cshlp.org/content/27/12/1318.full.pdf
Targeted inhibition of mutant IDH2 in leukemia cells induces cellular differentiation, Science, vol.340, pp.622-626, 2013. ,
Rational Design of Selective Allosteric Inhibitors of PHGDH and Serine Synthesis with Anti-tumor Activity, Cell Chem. Biol, vol.24, pp.55-65, 2017. ,
SMARCB1-mediated SWI/SNF complex function is essential for enhancer regulation, Nat. Genet, vol.49, pp.289-295, 2017. ,
DOI : 10.1038/ng.3746
URL : http://europepmc.org/articles/pmc5285474?pdf=render
On the origin of cancer cells, Science, vol.123, pp.309-314, 1956. ,
THE METABOLISM OF TUMORS IN THE BODY, J. Gen. Physiol, vol.8, pp.519-530, 1927. ,
Rhabdoid tumor of kidney. A report of 111 cases from the National Wilms' Tumor Study Pathology Center, Am. J. Surg. Pathol, vol.13, pp.439-458, 1989. ,
DOI : 10.1097/00000478-198906000-00001
Master transcription factors and mediator establish super-enhancers at key cell identity genes, Cell, vol.153, pp.307-319, 2013. ,
DOI : 10.1016/j.cell.2013.03.035
URL : https://doi.org/10.1016/j.cell.2013.03.035
Epigenetic antagonism between polycomb and SWI/SNF complexes during oncogenic transformation, Cancer Cell, vol.18, pp.316-328, 2010. ,
DOI : 10.1016/j.ccr.2011.01.016
URL : https://doi.org/10.1016/j.ccr.2011.01.016
Yeast SNF/SWI transcriptional activators and the SPT/SIN chromatin connection, Trends Genet. TIG, vol.8, pp.387-391, 1992. ,
DOI : 10.1016/0168-9525(92)90167-3
Myc regulates a transcriptional program that stimulates mitochondrial glutaminolysis and leads to glutamine addiction, Proc. Natl. Acad. Sci. U. S. A, vol.105, pp.18782-18787, 2008. ,
DOI : 10.1073/pnas.0810199105
URL : http://www.pnas.org/content/105/48/18782.full.pdf
Familial rhabdoid tumour "avant la lettre"-from pathology review to exome sequencing and back again, J. Pathol, vol.231, pp.35-43, 2013. ,
DOI : 10.1002/path.4225
Germline and somatic SMARCA4 mutations characterize small cell carcinoma of the ovary, hypercalcemic type, Nat. Genet, vol.46, pp.438-443, 2014. ,
Beyond histones-the expanding roles of protein lysine methylation, FEBS J, vol.284, pp.2732-2744, 2017. ,
Role of Tet1 in erasure of genomic imprinting, Nature, vol.504, pp.460-464, 2013. ,
TET2 Mutations Affect Non-CpG Island DNA Methylation at Enhancers and Transcription Factor-Binding Sites in Chronic Myelomonocytic Leukemia, Cancer Res, vol.75, pp.2833-2843, 2015. ,
IDH1 and IDH2 mutations in gliomas, N. Engl. J. Med, vol.360, pp.765-773, 2009. ,
Pyruvate kinase M2 at a glance, J. Cell Sci, vol.128, pp.1655-1660, 2015. ,
DOI : 10.1242/jcs.166629
URL : http://jcs.biologists.org/content/128/9/1655.full.pdf
PSAT1 regulates cyclin D1 degradation and sustains proliferation of non-small cell lung cancer cells, Int. J. Cancer, vol.136, pp.39-50, 2015. ,
VHL deficiency drives enhancer activation of oncogenes in clear cell renal cell carcinoma, 2017. ,
, , 2012.
, Pyruvate kinase M2 promotes de novo serine synthesis to sustain mTORC1 activity and cell proliferation, Proc. Natl. Acad. Sci. U. S. A, vol.109, pp.6904-6909
Clinicopathological and molecular characterization of SMARCA4-deficient thoracic sarcomas with comparison to potentially related entities, Mod. Pathol. Off. J. U. S. Can. Acad. Pathol. Inc, vol.30, pp.797-809, 2017. ,
Small cell carcinoma of the ovary, hypercalcemic type. A clinicopathological analysis of 150 cases, Am. J. Surg. Pathol, vol.18, pp.1102-1116, 1994. ,
Bortezomib resistance in multiple myeloma is associated with increased serine synthesis, Cancer Metab, vol.5, p.7, 2017. ,
Chemical modulators for epigenome reader domains as emerging epigenetic therapies for cancer and inflammation, Curr. Opin. Chem. Biol, vol.39, pp.116-125, 2017. ,
The CREBBP Acetyltransferase Is a Haploinsufficient Tumor Suppressor in B-cell Lymphoma, Cancer Discov, vol.7, pp.322-337, 2017. ,
Inhibition of histone H3K79 methylation selectively inhibits proliferation, self-renewal and metastatic potential of breast cancer, Oncotarget, vol.5, pp.10665-10677, 2014. ,
, , 2002.
, Cell cycle arrest and repression of cyclin D1 transcription by INI1/hSNF5, Mol. Cell. Biol, vol.22, pp.5975-5988