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Complexe SWI/SNF et cancer _ Altérations génétiques et anomalies métaboliques

Abstract : Nearly 20 years ago, the demonstration of truncated bi-allelic mutations in the SMARCB1 gene in rhabdoid tumors established the first demonstration of alterations in the SWI/SNF chromatin remodeling complex in oncology. Since then, the advent of high-throughput molecular analysis techniques applied to oncology has shown that alterations in other genes of the SWI/SNF complex are present in a wide variety of cancers. Through the presentation of several types of SWI/SNF deficient tumors and our models of rhabdoid tumors, we show that the loss ofSMARCB1 is associated with an increase of the serine biosynthesis pathway and the downstream metabolic pathways important for oncogenesis.These results could lead to a therapeutic option for rhabdoid tumors or, more generally, for other models of SWI/SNF-deficient tumors. Finally, the prospect of these metabolic changes with the epigenetic alterations observed in SWI / SNF deficient tumors may be relevant to continue to deepen our knowledge of these tumors.
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Submitted on : Tuesday, September 18, 2018 - 2:40:12 PM
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Julien Masliah-Planchon. Complexe SWI/SNF et cancer _ Altérations génétiques et anomalies métaboliques. Biochimie [q-bio.BM]. Université Paris Saclay (COmUE), 2018. Français. ⟨NNT : 2018SACLS112⟩. ⟨tel-01876474⟩

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