Skip to Main content Skip to Navigation
Theses

Mort subite d'origine cardiaque à la phase aigüe de l'infarctus du myocarde : physiopathologie des troubles du rythmes ventriculaire

Abstract : The majority of cardiac sudden deaths correspond to a myocardial infarction, ie an acute occlusion of a coronary artery, complicated by ventricular arrhythmia. It is not known why, at equivalent degree of myocardial ischemia, at equal age, sex and clinical status, one patient will develop ventricular arrhythmias while another will have no rhythmic complication.In this study, we will discuss two approaches to the study of sudden death. On the one hand, the collection of biological and clinical data and on the other hand a genetic approach.Thus, it has been shown that the Gln27Glu polymorphism in the ADRB2 gene seems to predispose patients to the rapid onset of ventricular fibrillation in the setting of cardiac ischemia. This study also suggests that the presence of variants in the GJA1 gene near residues subjected to methylation may be related to the occurrence of ventricular fibrillation in patients with myocardial infarction.These new data help to improve knowledge on sudden death in the acute phase of myocardial infarction and to consider new prevention strategies in the future
Complete list of metadatas

Cited literature [196 references]  Display  Hide  Download

https://tel.archives-ouvertes.fr/tel-01875736
Contributor : Abes Star :  Contact
Submitted on : Monday, September 17, 2018 - 4:51:00 PM
Last modification on : Thursday, February 6, 2020 - 10:56:02 AM
Long-term archiving on: : Tuesday, December 18, 2018 - 3:23:21 PM

File

TH2018MANATIABDULWAHEED.pdf
Version validated by the jury (STAR)

Identifiers

  • HAL Id : tel-01875736, version 1

Collections

Citation

Abdul Waheed Manati. Mort subite d'origine cardiaque à la phase aigüe de l'infarctus du myocarde : physiopathologie des troubles du rythmes ventriculaire. Cardiologie et système cardiovasculaire. Université de Lyon, 2018. Français. ⟨NNT : 2018LYSE1112⟩. ⟨tel-01875736⟩

Share

Metrics

Record views

446

Files downloads

3274