Skip to Main content Skip to Navigation
Theses

Preparation of polymeric nanoparticles for topical anti-inflammatory applications

Abstract : The objective of this PhD thesis was to extract the Nigella Sativa L. Seeds Essential Oil and its encapsulation together with indomethacin within polymeric nanoparticles in order to reduce taken amount and to enhance indomethacin cutaneous penetration, and anti-inflammatory activity. To this direction poly-epsilon-caprolactone based nanoparticles were designed using nanoprecipitation method. A systematic study was performed to figure out the effect of process and formulation parameters on the characteristics of obtained nanoparticles. Once the effects of all parameters were studied, then indomethacin and Nigella Sativa L. Seeds Essential Oil was encapsulated separately. Consequently, both together indomethacin and Nigella Sativa L. Seeds Essential Oil was encapsulated. Then prepared nanoparticles were characterized in terms of stability, encapsulation efficiency. In addition, ex vivo skin penetration and in vivo anti-inflammatory activity of designed nanoparticles was investigated
Document type :
Theses
Complete list of metadatas

Cited literature [438 references]  Display  Hide  Download

https://tel.archives-ouvertes.fr/tel-01875707
Contributor : Abes Star :  Contact
Submitted on : Monday, September 17, 2018 - 4:34:08 PM
Last modification on : Wednesday, November 20, 2019 - 3:27:28 AM
Long-term archiving on: : Tuesday, December 18, 2018 - 2:59:55 PM

File

TH2018BADRIWAISUDIN.pdf
Version validated by the jury (STAR)

Identifiers

  • HAL Id : tel-01875707, version 1

Collections

Citation

Waisudin Badri. Preparation of polymeric nanoparticles for topical anti-inflammatory applications. Pharmacology. Université de Lyon, 2018. English. ⟨NNT : 2018LYSE1095⟩. ⟨tel-01875707⟩

Share

Metrics

Record views

360

Files downloads

282