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Theses

Imagerie par résonnance magnétique moléculaire et inflammation des barrières biologiques dans les modèles de sclérose en plaques

Abstract : Developing new strategies to detect disease activity in multiple sclerosis (MS) is essential to improve the diagnosis and follow-up of this pathology. To this aim, we used microparticles of iron oxide (MPIO) coupled to an antibody specific to the P-selectin or MAdCAM-1 protein. In this thesis, we establish that molecular MRI specific to P-selectin protein is able to detect the pathological events that take place in the spinal cord of chronic and relapsing-remitting models of MS in mice. Interestingly, we show here that this MRI technique can predict the apparition of relapses and recoveries in EAE. Moreover, we demonstrate that MRI specific to MAdCAM-1 protein is able to detect the gut inflammation that takes place in models of bowel diseases or MS. The innovative MRI techniques developed in this study could bring new advances in the diagnosis and prognosis of MS relapses by targeting gut inflammation. In the last part of this work, we report that the glymphatic system also exists in the spinal cord parenchyma of the mouse. In EAE, the activity of this system is reduced in the spinal cord but not in the brain or cerebellum. This alteration is associated to inflammatory cell accumulation within the perivascular space, AQP4 disorganization and leads to a large increase of ventricular volume. These disruptions could contribute to the MS pathophysiology. Our results hold significant promise for the development of new therapeutic strategies.
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https://tel.archives-ouvertes.fr/tel-01870716
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Submitted on : Sunday, September 9, 2018 - 1:02:14 AM
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  • HAL Id : tel-01870716, version 1

Citation

Antoine Fournier. Imagerie par résonnance magnétique moléculaire et inflammation des barrières biologiques dans les modèles de sclérose en plaques. Médecine humaine et pathologie. Normandie Université, 2017. Français. ⟨NNT : 2017NORMC410⟩. ⟨tel-01870716⟩

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