, Detection of activity at G1, despite the addition of Adrenaline and Nifedipine , indicates that there is an electrical problem in the setup, because all physiological , calcium-driven activity should be extinguished. Nothing can be deduced about the culture, electrical problems must be fixed (generally by physically grounding faulty electrodes) and the experiment must be re-run
, Detection of activity at G1, maintained by Adrenaline but extinguished by Nifedipine indicates that the observed activity results from ? cells . Islets are of poor quality
, Detection of activity at G1 extinguished by Adrenaline suggests that activity results from ? cells , and not from ? cells , which should be activated by Adrenaline. Islets are of moderate activity, as it suggests ? cell hypersensitivity to glucose
The preparation is inactive at low glucose (G1), activates at high glucose (G15), shows physiological response to dose-responses and hormones ,
, The preparation is inactive at low glucose (G1), activates at high glucose (G15), shows physiological response to dose-responses and hormones
, The preparation is inactive at low glucose (G1), activates at high glucose (G15), and shows poor or partial response to dose-responses and hormones Islets have bad sensitivity but are nevertheless responsive to stimuli: they are therefore of good quality
, Matthieu Raoux, and Jochen Lang. Slow potentials encode intercellular coupling and insulin demand in pancreatic beta cells
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