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The oxytocinergic descending control of pain and its modulation by neonatal maternal separation

Abstract : Oxytocin is a small peptide synthesized in hypothalamic neurons. She is well known for its roles in reproduction and social interactions, especially in mother-infant interactions, but also displays analgesic effects. During this thesis, I tried to get a better understanding of the circuits underlying OT analgesia. Then, I tried to determine if neonatal maternal separation, affecting mother-infant interactions, alters adult pain responses and oxytocin analgesia. This work allowed to identify a subgroup of oxytocinergic neurons in the hypothalamus, able to decrease pain through a dual action. They directly inhibit nociceptive transmission in the spinal cord and control the activity of another population of oxytocinergic neurons releasing the peptide in the bloodstream. Our work on maternal separation shows that it induces nociceptive hypersensitivity at adulthood, and a dysfunction in oxytocin analgesia.
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https://tel.archives-ouvertes.fr/tel-01860640
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Submitted on : Thursday, August 23, 2018 - 3:19:06 PM
Last modification on : Friday, October 23, 2020 - 4:51:50 PM
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Meggane Melchior. The oxytocinergic descending control of pain and its modulation by neonatal maternal separation. Neuroscience. Université de Strasbourg, 2018. English. ⟨NNT : 2018STRAJ013⟩. ⟨tel-01860640⟩

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