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Modelling of roll compaction process by finiite element method

Abstract : In the pharmaceutical industry, dry granulation by roll compaction is a process of size enlargement of powder into granules with good flowability for subsequent die compaction process. Understanding the roll compaction process and optimizing manufacturing efficiency is limited using the experimental approach due to the high cost of powder, time-consuming and the complexity of the process. In this work, a 3D Finite Element Method (FEM) model was developed to identify the critical material properties, roll press designs and process parameters controlling the quality of the product. The Drucker-Prager Cap (DPC) model was used to describe the powder compaction behavior and was determined based on standard calibration method. To overcome the complexity involving two different mechanisms of powder feeding by the screw and powder compaction between rolls, a novel combined approach of Discrete Element Method (DEM), used to predict the granular material flow in the feed zone and the Finite Elements Method (FEM) employed for roll compaction, was developed. Lastly, for a more realistic roll compaction modelling, allowing the fluctuation of the gap between rolls, a Coupled-Eulerian Lagrangian (CEL) approach was developed. FEM simulation results clearly show the effect of different process parameters on roll pressure and density distribution in the compaction zone of powder between the rolls. Moreover, results show that using a cheek-plates sealing system causes a nonuniform roll pressure and density distribution with the highest values in the middle and the lowest at the edges. On the other hand, the resultant pressure and density distributions with the rimmed-roll obtained higher values in the edges than in the middle and overall a more uniform distribution. The combined DEM-FEM methodology clearly shows a direct correlation between the particle velocity driven by the screw conveyor to the feed zone and the roll pressure, both oscillating in the same period. This translates into an anisotropic ribbon with a density profile varying sinusoidally along its length. To validate the results, the simulations are compared with literature and experimentally measured values in order to assess the ability of the model to predict the properties of the produced ribbons.
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https://tel.archives-ouvertes.fr/tel-01860573
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Submitted on : Thursday, August 23, 2018 - 2:50:17 PM
Last modification on : Tuesday, October 20, 2020 - 10:46:50 AM
Long-term archiving on: : Saturday, November 24, 2018 - 2:30:13 PM

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  • HAL Id : tel-01860573, version 1

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Alon Mazor. Modelling of roll compaction process by finiite element method. Chemical and Process Engineering. Ecole des Mines d'Albi-Carmaux, 2017. English. ⟨NNT : 2017EMAC0009⟩. ⟨tel-01860573⟩

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