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Nanohybrides superparamagnétiques à luminescence persistante : conception et application au marquage cellulaire pour la vectorisation magnétique in vivo

Abstract : Cell therapy aims to use cells as injectable medicines in order to enhance damaged organs or tissues repair. Some cells have the ability to promote new blood vessels growth. Therefore, they have an interest in revascularization of ischemic tissues and are potential candidates for cell therapy in peripheral ischemia or myocardial infarction. Being able to determine these cell's fates after in vivo injection is a major step to better understand the mechanisms of such treatments efficiency. However, following this phenomenon is challenging and rarely described in scientific litterature. Only some applications of nanotechnologies to follow labeled cells in vitro have been published. But limitations as implementation complexity or a low sensitivity prevent from using these techniques in vivo. This phD work describes the development of new hybrids nanoparticules associating optical and magnetic resonance imaging modalities in order to efficiently label cells that have a therapeutic potential. Developed protocols allowed us to follow magnetic cell vectorisation after injection in mice in real time.
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Eliott Teston. Nanohybrides superparamagnétiques à luminescence persistante : conception et application au marquage cellulaire pour la vectorisation magnétique in vivo. Chimie organique. Université Sorbonne Paris Cité, 2016. Français. ⟨NNT : 2016USPCB025⟩. ⟨tel-01844266⟩

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