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Exploration du discours dans le vieillissement typique et la maladie d'Alzheimer : liens avec les modifications neurocognitives sous-jacentes

Abstract : Language is the most preserved cognitive function from the effects of aging. Unlike typical aging, Alzheimer's disease (AD) is characterized by an early impairment. Analysis of discourse may reveal more difficulties than other tests since it mobilizes a large set of cognitive functions. This work aims to analyze various discourses in AD patients and participants with typical aging, in relation to various cognitive tests as well as neuroimaging data. One study focused on a memory-based discourse. A second study compared a memory-based and in a picture-based discourse. Patients' difficulties were correlated on one hand with memory impairment in the memory-based discourse and on the second hand with lexical-executive impairment in the picture-based discourse. A final study focused on discourse variability in the general aging population. A cluster analysis revealed four profiles of speakers. Among them, an "off-topic" profile could reflect a grey zone between normal and pathological aging. This work allowed us to shed light on deficit markers and compensatory strategies in prodromal AD, in relation with cognitive and cerebral changes. In particular, many difficulties may actually be related to memory or executive impairment, regardless of a language alteration.
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Aurélie Pistono. Exploration du discours dans le vieillissement typique et la maladie d'Alzheimer : liens avec les modifications neurocognitives sous-jacentes. Neurosciences. Université Paul Sabatier - Toulouse III, 2017. Français. ⟨NNT : 2017TOU30147⟩. ⟨tel-01832154⟩

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