Skip to Main content Skip to Navigation
Theses

Identification des contaminants présents à la surface de lactose à usage pharmaceutique et analyse de l’impact de leur présence sur les interactions avec différents principes actifs

Abstract : The discovery of the problem will go through training techniques at the nanoscale characterization and chemical analysis, the discovery of the industrial problem in society Armor Proteins, the validation of a pharmaceutical lactose. With the aim to increase our knowledge on powders for food or pharmaceutical use, we propose to study the effect of manufacturing processes, shaping, granulation on the reactivity of powders. The first part is devoted to the effect of purity on interactions-Lactose Lactose and Lactose-API measured / quantified by near-field techniques (AFM, SMM, MSAFM) under ambient atmosphere and under stressful conditions storage. Deriving a second portion of the preceding part will highlight the effects of interactions on different pharmaceutical formulations, such as direct compression and with a Dry Powder Inhalation Inhaler. All of this work will help to understand the impact of purity surface Lactose Pharmaceutical quality and stability of formulations for inhalation and compression.
Complete list of metadatas

Cited literature [224 references]  Display  Hide  Download

https://tel.archives-ouvertes.fr/tel-01828185
Contributor : Abes Star :  Contact
Submitted on : Tuesday, July 3, 2018 - 9:29:10 AM
Last modification on : Wednesday, July 4, 2018 - 1:08:45 AM
Long-term archiving on: : Monday, October 1, 2018 - 7:48:15 AM

File

85091_THOMAS_2018_archivage.pd...
Version validated by the jury (STAR)

Identifiers

  • HAL Id : tel-01828185, version 1

Citation

Cedric Thomas. Identification des contaminants présents à la surface de lactose à usage pharmaceutique et analyse de l’impact de leur présence sur les interactions avec différents principes actifs. Physique Médicale [physics.med-ph]. Université Bourgogne Franche-Comté, 2018. Français. ⟨NNT : 2018UBFCK012⟩. ⟨tel-01828185⟩

Share

Metrics

Record views

591

Files downloads

530