Skip to Main content Skip to Navigation
Theses

Connectivité fonctionnelle des réseaux neuronaux intégratifs du système limbique étudiée en IRM fonctionnelle d'activation par stimuli olfactifs

Abstract : The precise mechanisms at the origin of the depression are not yet elucidated. The advent of functional neuroimaging techniques such as functional magnetic resonance imaging (fMRI) has provided a powerful tool not only for defining the neurobiological circuits disturbed in depression, but also for better understanding the contribution of each region. The objectives of this work were to highlight: (i) the clusters involved in the hedonic evaluation of the smell (ii) the functional brain abnormalities underlying the olfactory deficits in the major depressive episode (MDE) and (iii) the modulations of these abnormalities following antidepressant treatment. Thirty-eight depressive patients and thirty healthy subjects were selected to perform a fMRI examination with three tasks: recognizing three smells which are the spearmint, sandalwood and wine lees. Based on our study, we can conclude that depressed patients have functional abnormalities in the thalamus, this region may be considered as a good marker for the prognosis of depression. In addition, fMRI could be a good tool to evaluate the treatment performance of antidepressant treatment.
Complete list of metadatas

Cited literature [254 references]  Display  Hide  Download

https://tel.archives-ouvertes.fr/tel-01823926
Contributor : Abes Star :  Contact
Submitted on : Tuesday, June 26, 2018 - 3:51:12 PM
Last modification on : Tuesday, September 29, 2020 - 4:37:40 AM
Long-term archiving on: : Wednesday, September 26, 2018 - 9:48:32 PM

File

74295_SKEIF_2017_diffusion.pdf
Version validated by the jury (STAR)

Identifiers

  • HAL Id : tel-01823926, version 1

Collections

Citation

Hanadi Skeif. Connectivité fonctionnelle des réseaux neuronaux intégratifs du système limbique étudiée en IRM fonctionnelle d'activation par stimuli olfactifs. Physique Médicale [physics.med-ph]. Université Paris Saclay (COmUE), 2017. Français. ⟨NNT : 2017SACLS537⟩. ⟨tel-01823926⟩

Share

Metrics

Record views

237

Files downloads

187