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A study of mouse central extended amygdala : general connectivity and cell-type specific circuits ; functional implications in pain

Abstract : Central extended amygdala (EAc) is a forebrain macrosystem that plays important roles in fear, anxiety and pain. The two key components, the lateral bed nucleus of stria terminalis (STL) and central nucleus of amygdala (CeA), are highly similar in their neurochemical, connectional, and functional features. Despite this simplified view of STL and CeA, much remains elusive of the mesoscopic inputs and outputs of EAc subdivisions in mouse model. Also, it is not known whether the connectional similarities are also shared at cellular level. Here, we addressed these question in comparative ways in mice. We found rich preferential inputs and outputs to different subdivisions of EAc, as well as convergent and divergent inputs. We also found two non-overlapping cell groups expressing either protein kinase C delta (PKCδ) or somatostatin (SOM) organize the parallel cell-type specific neuronal circuits in STL and CeA. Finally, preliminary data suggest that PKCδ in STL and CeA might be implicated in tonic pain. These parallel but also differential structural organizations of neuronal circuits in EAc might underlie similar and dissociable functional aspects of anxiety, fear and pain.
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https://tel.archives-ouvertes.fr/tel-01820639
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Submitted on : Friday, June 22, 2018 - 4:13:30 AM
Last modification on : Wednesday, March 18, 2020 - 9:48:53 AM
Long-term archiving on: : Monday, September 24, 2018 - 9:21:25 PM

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  • HAL Id : tel-01820639, version 1

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Jiahao Ye. A study of mouse central extended amygdala : general connectivity and cell-type specific circuits ; functional implications in pain. Neurobiology. Université de Strasbourg, 2018. English. ⟨NNT : 2018STRAJ006⟩. ⟨tel-01820639⟩

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