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Analyse fonctionnelle du récepteur de l'éphrine de Myzus persicae et mise en évidence de son rôle dans la transmissino du virus de la jaunisse du navet

Abstract : Poleroviruses infect a wide range of economically important plants. They are transmitted in a circulative and non-propagative mode by an insect vector, the aphid. The virus particles are acquired by aphids when ingesting the sap from an infected plant and cross successively the epithelia of the midgut and the salivary gland cells by a transcytosis mechanism that relies on the presence of unknown receptors.The ephrin receptor (Eph) is a membrane protein which contains a domain able to bind in yeast to the structural proteins of poleroviruses. By developing methods based on RNA interference, we have shown that oral acquisition of double-stranded RNA targeting Eph in the aphid Myzus persicae can reproducibly reduce polerovirus internalization into the aphid's body. Such treated aphids transmit the virus to plants with a lower efficiency. Eph could therefore function as a receptor for poleroviruses in M. persicae.
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https://tel.archives-ouvertes.fr/tel-01820620
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Submitted on : Friday, June 22, 2018 - 3:47:20 AM
Last modification on : Tuesday, March 17, 2020 - 1:33:16 AM
Long-term archiving on: : Tuesday, September 25, 2018 - 11:02:41 AM

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  • HAL Id : tel-01820620, version 1

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Michaël Mulot. Analyse fonctionnelle du récepteur de l'éphrine de Myzus persicae et mise en évidence de son rôle dans la transmissino du virus de la jaunisse du navet. Virologie. Université de Strasbourg, 2018. Français. ⟨NNT : 2018STRAJ004⟩. ⟨tel-01820620⟩

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